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Trackers› Clinical trials› Indiana
Clinical trial register · United States · industry-sponsored

Clinical Trials in Indiana, 2026

Every industry-sponsored study on the ClinicalTrials.gov registry that lists a US site and is open, about to open, active-but-closed, or enrolling by invitation. This deliberately excludes academic and other non-industry sponsors — the full US registry across all sponsors runs to over 22,000 recruiting studies alone.

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Source: ClinicalTrials.gov. Complete coverage of the industry-sponsored slice — all 9118 matching records are in this view (non-industry sponsors are out of scope by design, not truncated). Synced 06 Oct 2026, 03:16 UTC
9118
Studies in scope
industry-sponsored, all four open statuses
4945
Recruiting now
open to new participants
2189
Lead sponsors
across recruiting studies
Top states
California 5290 Florida 4430 Illinois 2481 Georgia 2368 Arizona 2238
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
Eli Lilly and Company49 AstraZeneca41 AbbVie41 Janssen Research & Development, LLC39 Merck Sharp & Dohme LLC32
State
California5290 Florida4430 Illinois2481 Georgia2368 Arizona2238
All 51 states
Target enrolment
to

Trials with a site in Indiana

1124 of 9118 studies
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Status
Study
Lead sponsor
Phase
Enrol
US states
Start
Active, closed
Open-Label Extension Study of Saroglitazar Magnesium in Participants With Primary Biliary Cholangitis
NCT06427395Primary Biliary Cholangitis
DrugSaroglitazar Magnesium
Zydus Therapeutics Inc.
Phase 3
102
California, Colorado, Connecticut, Florida, Georgia, Indiana, New York, North Carolina
2024-07-16
Active, closed
Bomedemstat vs Hydroxyurea for Essential Thrombocythemia (MK-3543-007)
NCT06456346Essential Thrombocythemia
DrugsBomedemstat·Hydroxyurea
Merck Sharp & Dohme LLC
Phase 3
300
Arizona, California, Colorado, Connecticut, Indiana, Michigan, Nevada, North Carolina
2024-07-16
Recruiting
Galleri® in the Medicare Population.
NCT05673018Cancer
GRAIL, Inc.
Not applicable
50,000
Arkansas, California, Florida, Georgia, Indiana, Louisiana, Missouri, Oregon
2024-07-12
Active, closed
A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria
NCT06445023Chronic Spontaneous Urticaria
DrugBarzolvolimab
Celldex Therapeutics
Phase 3
963
Alabama, California, Colorado, Florida, Idaho, Illinois, Indiana, Kentucky
2024-07-11
Active, closed
A Study to Assess the Effects of Dexpramipexole in Participants With Eosinophilic COPD
NCT06533553Chronic Obstructive Pulmonary Disease
DrugDexpramipexole Dihydrochloride
Areteia Therapeutics
Phase 2
30
Arkansas, California, Florida, Illinois, Indiana, Iowa, Maryland, Michigan
2024-07-09
Active, closed
Safety and Efficacy of VDPHL01 in Males and Females With AGA
NCT06527365Androgenetic Alopecia, AGA, Male Pattern Baldness
DrugVDPHL01
Veradermics, Inc.
Phase 2
70
California, Indiana, New Jersey, Utah
2024-07-08
Recruiting
A Study to Assess Adverse Events, Change in Disease Activity, and How the Drug Moves Through the Body in Children With Juvenile Psoriatic Arthritis (jPsA) Receiving Subcutaneously Injected Risankizumab or Adalimumab
NCT06100744Juvenile Psoriatic Arthritis
DrugsSkyrizi·Risankizumab·Adalimumab
AbbVie
Phase 3
40
Arkansas, District of Columbia, Florida, Indiana, Minnesota, New York, North Carolina, Ohio
2024-07-08
Active, closed
Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL PFS with1mL Pre-filled Syringe in Adult Participants With Autoimmune Disease
NCT06293365Sjögrens Disease, Systemic Lupus Erythematosus, Rheumatoid Arthritis
DrugIanalumab
Novartis Pharmaceuticals
Phase 2
155
Alabama, California, Florida, Georgia, Indiana, Louisiana, Michigan, Ohio
2024-07-02
Recruiting
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
NCT06465069Metastatic Solid Tumor, Recurrent Solid Tumor, Advanced Solid Tumor, Urinary Bladder Neoplasm
Eli Lilly and Company
Phase 1
420
California, Colorado, Florida, Georgia, Illinois, Indiana, Massachusetts, Michigan
2024-07-01
Active, closed
A Phase III Study to Investigate the Efficacy and Safety of Anifrolumab in Adults With Chronic and/or Subacute Cutaneous Lupus Erythematosus
NCT06015737Cutaneous Lupus Erythematosus
AstraZeneca
Phase 3
339
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Illinois, Indiana
2024-06-29
Recruiting
A Study to Evaluate the Safety and Efficacy of a Single Dose of RABI-767 in Participants With Acute Pancreatitis
NCT06080789Acute Pancreatitis
Panafina, Inc.
Phase 2
36
Arkansas, California, Colorado, Florida, Illinois, Indiana, Maryland, Michigan
2024-06-28
Recruiting
Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
NCT06324357Metastatic Breast Cancer, Metastatic Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Esophageal Adenocarcinoma
DrugsZongertinib·Zanidatamab·Ado-trastuzumab emtansine·Trastuzumab emtansine
Boehringer Ingelheim
Phase 1/2
768
California, Connecticut, Florida, Illinois, Indiana, Iowa, Massachusetts, Michigan
2024-06-28
Recruiting
TEMPUS ARIES: A Biobank Registry Platform Study in Oncology
NCT06207032Cancer
Tempus AI
Observational
500
Alabama, California, Connecticut, Florida, Georgia, Illinois, Indiana, Kentucky
2024-06-26
Active, closed
A Study to Evaluate the Efficacy and Safety of Bimekizumab Compared to Ustekinumab in Children and Adolescents From 6 Years to Less Than 18 Years of Age With Moderate to Severe Plaque Psoriasis
NCT06425549Moderate to Severe Plaque Psoriasis
DrugsBimekizumab·Ustekinumab
UCB Biopharma SRL
Phase 3
176
California, Indiana, South Carolina, Texas
2024-06-25
Recruiting
Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis
NCT06465810Transthyretin Amyloidosis, ATTR-CM, ATTRv-PN, ATTR
AstraZeneca
Observational
1,850
California, Connecticut, District of Columbia, Illinois, Indiana, Maryland, Massachusetts, Minnesota
2024-06-25
Active, closed
Long-term, Open-label Study of SAR447537 (INBRX-101) in Adults With Alpha-1 Antitrypsin Deficiency Emphysema
NCT05897424Alpha 1-Antitrypsin Deficiency, Emphysema
Sanofi
Phase 2
185
Alabama, Arizona, California, Colorado, Connecticut, Florida, Indiana, Massachusetts
2024-06-20
Recruiting
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
NCT06424288Heart Failure
DrugsVicadrostat·Dapagliflozin
Boehringer Ingelheim
Phase 3
6,712
Alabama, California, Connecticut, Florida, Georgia, Idaho, Illinois, Indiana
2024-06-17
Active, closed
Cadisegliatin as Adjunctive Therapy to Insulin in Participants With Type 1 Diabetes
NCT06334133Diabetes Mellitus, Type 1
DrugCadisegliatin
vTv Therapeutics
Phase 3
150
Arizona, Arkansas, California, Colorado, Florida, Georgia, Idaho, Indiana
2024-06-14
Active, closed
A Study Comparing Pre- and Post-Change Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma
NCT06425991Multiple Myeloma
DrugTeclistamab
Janssen Research & Development, LLC
Phase 1
108
Arizona, Colorado, Florida, Georgia, Indiana, Ohio, Texas
2024-06-07
Recruiting
EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)
NCT06401421Breast Cancer
Exact Sciences Corporation
Observational
1,800
Alaska, California, Colorado, Florida, Illinois, Indiana, Kansas, Kentucky
2024-06-07
Active, closed
Study Comparing Tarlatamab and Durvalumab Versus Durvalumab Alone in First-Line Extensive-Stage Small-Cell Lung Cancer (ES-SCLC) Following Platinum, Etoposide and Durvalumab
NCT06211036Extensive-Stage Small-Cell Lung Cancer, Small-Cell Lung Cancer
DrugsTarlatamab·Durvalumab
Amgen
Phase 3
563
Alabama, California, Connecticut, Georgia, Illinois, Indiana, Louisiana, Massachusetts
2024-06-05
Recruiting
A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)
NCT06439277Obesity, Weight Gain
DrugTirzepatide
Eli Lilly and Company
Phase 3
300
California, Delaware, Idaho, Illinois, Indiana, New York, Texas, Utah
2024-06-03
Active, closed
ReNEW:Phase 3 Study of Efficacy, Safety & Pharmacokinetics of Subcutaneous Injections of Elamipretide in Subjects With Dry Age-Related Macular Degeneration (Dry AMD)
NCT06373731Age Related Macular Degeneration (ARMD)
DrugElamipretide
Stealth BioTherapeutics Inc.
Phase 3
313
Arizona, California, Colorado, Connecticut, Florida, Illinois, Indiana, Maryland
2024-05-30
Recruiting
Post-Market Clinical Study of Functional Motion Outcomes in Subjects Treated With the Minuteman Device
NCT06355791Degenerative Conditions of the Lumbar Spine, Lumbar Spinal Stenosis, Spondylolisthesis
Spinal Simplicity LLC
Not applicable
150
Georgia, Indiana, Kansas, Minnesota, Oregon, West Virginia
2024-05-29
Active, closed
A Study Evaluating Anvumetostat in Combination With Other Therapies in Participants With Advanced Gastrointestinal, Biliary Tract, or Pancreatic Cancers With Homozygous Methylthioadenosine Phosphorylase (MTAP)-Deletion (MTAPESTRY 103)
NCT06360354Advanced Gastrointestinal, Biliary Tract, and Pancreatic Cancers
DrugsAnvumetostat·Modified FOLFIRINOX·Cetuximab·Nab-paclitaxel
Amgen
Phase 1
120
California, Colorado, Connecticut, Illinois, Indiana, Kentucky, Massachusetts, Missouri
2024-05-29
Recruiting
A Study of Pitolisant in Patients With Prader-Willi Syndrome
NCT06366464Prader-Willi Syndrome
DrugPitolisant
Harmony Biosciences Management, Inc.
Phase 3
134
California, Colorado, Delaware, Georgia, Illinois, Indiana, Maryland, Minnesota
2024-05-28
Recruiting
Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Subjects With Limbal Stem Cell Deficiency
NCT06452316Limbal Stem Cell Deficiency
DrugCSB-001 Ophthalmic
Claris Biotherapeutics, Inc.
Phase 1
75
California, Indiana, Minnesota, Oregon, Texas
2024-05-15
Recruiting
Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients
NCT06372964Bipolar Depression
DrugLumateperone
Intra-Cellular Therapies, Inc.
Phase 3
384
Alabama, Arkansas, California, Colorado, Florida, Georgia, Illinois, Indiana
2024-05-14
Recruiting
Endovascular AAA Intervention Using the GORE® EXCLUDER® Conformable AAA Endoprosthesis or Iliac Branch Endoprosthesis
NCT06218875AAA - Abdominal Aortic Aneurysm
W.L.Gore & Associates
Observational
2,000
Arkansas, California, Florida, Georgia, Illinois, Indiana, Kentucky, Louisiana
2024-05-07
Recruiting
A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease
NCT06164730Heterozygous Familial Hypercholesterolemia, Premature Coronary Heart Disease
DrugVERVE-102
Verve Therapeutics, Inc.
Phase 1
85
Alabama, California, Florida, Indiana, North Carolina, Pennsylvania, Texas, Washington
2024-04-30
Recruiting
Phase III, Open-label Study of First-line Osimertinib With or Without Datopotamab Deruxtecan for EGFRm Locally Advanced or Metastatic Non-small Cell Lung Cancer
NCT06350097Non-small Cell Lung Cancer
DrugsDato-DXd·Osimertinib
AstraZeneca
Phase 3
582
California, Connecticut, District of Columbia, Florida, Hawaii, Illinois, Indiana, Maryland
2024-04-29
Active, closed
S095035 as a Single Agent and in Combination in Adult Participants With Advanced or Metastatic Solid Tumors With Deletion of MTAP
NCT06188702MTAP-deleted Solid Tumors
DrugTNG462
Servier Bio-Innovation LLC
Phase 1/2
60
Florida, Indiana, Ohio, Tennessee, Texas
2024-04-29
Active, closed
A Study Evaluating APG777 in Atopic Dermatitis
NCT06395948Atopic Dermatitis
DrugAPG777
Apogee Therapeutics, Inc.
Phase 2
470
California, Connecticut, Florida, Georgia, Illinois, Indiana, Kentucky, Maryland
2024-04-29
Active, closed
Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta
NCT05972551Osteogenesis Imperfecta
DrugRomosozumab
Amgen
Phase 3
111
Alabama, Arizona, California, Delaware, Florida, Georgia, Indiana, Maryland
2024-04-22
Active, closed
A Central Preservation and Assessment Service to Optimize Donor Kidney Allocation
NCT06263023Organ Preservation
34 Lives, PBC
Observational
80
Illinois, Indiana, Missouri, New York, North Carolina, Wisconsin
2024-04-19
Recruiting
A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer
NCT06319820Non-Muscle Invasive Bladder Neoplasms
DrugGemcitabine
Janssen Research & Development, LLC
Phase 3
641
Arkansas, California, Colorado, Florida, Illinois, Indiana, Kansas, Louisiana
2024-04-18
Active, closed
A Study to Evaluate Mavacamten in Adolescents With Symptomatic Obstructive Hypertrophic Cardiomyopathy
NCT06253221Cardiomyopathy, Hypertrophic
DrugMavacamten
Bristol-Myers Squibb
Phase 3
44
Alabama, Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana
2024-04-17
Recruiting
A Study Assessing KB707 for the Treatment of Advanced Solid Tumor Malignancies Affecting the Lungs
NCT06228326Lung Cancer, Non-small Cell, Lung Cancer Metastatic, Solid Tumor, Adult, Advanced Cancer
DrugsKB707·Docetaxel·Keytruda·Pembrolizumab
Krystal Biotech, Inc.
Phase 1/2
250
Alabama, Arizona, California, Florida, Indiana, Louisiana, Michigan, Ohio
2024-04-17
Recruiting
The Artisse™ Intrasaccular Device is Indicated for the Treatment of Wide-neck Bifurcating Intracranial Aneurysms (IAs).
NCT02998229Intracranial Aneurysm
Medtronic Neurovascular Clinical Affairs
Not applicable
300
California, Colorado, Connecticut, Florida, Illinois, Indiana, Iowa, Massachusetts
2024-04-16
Active, closed
P-CD19CD20-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With B Cell Malignancies
NCT06014762Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, High-grade B-cell Lymphoma, Primary Mediastinal Large B-cell Lymphoma (PMBCL), Transformed Follicular Lymphoma (tFL)
DrugRimiducid
Poseida Therapeutics, Inc.
Phase 1
120
California, Florida, Indiana, Louisiana, Michigan, New York, North Carolina, Ohio
2024-04-16
Recruiting
Aptis PRUJ Prosthesis for the Treatment of Patients With Proximal Radial Ulna Joint Disorders.
NCT05796908Arthritis, Unstable Radial Head, Proximal Radioulnar Joint Instability, Decreased Motion at the Proximal Radioulnar Joint and/or the Radio-humeral Joint
Aptis Medical
Not applicable
84
Indiana, Kentucky, Massachusetts, Ohio, Pennsylvania, Wisconsin
2024-04-12
Active, closed
A Study of Barzolvolimab in Patients With Prurigo Nodularis
NCT06366750Prurigo Nodularis
DrugBarzolvolimab
Celldex Therapeutics
Phase 2
140
Alabama, Arizona, California, Florida, Georgia, Idaho, Illinois, Indiana
2024-04-12
Recruiting
Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations
NCT06357533Non-Small Cell Lung Cancer
DrugsRilvegostomig·Dato-DXd·Keytruda·Pembrolizumab
AstraZeneca
Phase 3
675
Alaska, Arizona, Arkansas, California, Florida, Georgia, Illinois, Indiana
2024-04-11
Active, closed
FID-007 and Cetuximab in Treating Patients With Advanced Head and Neck Squamous Cell Carcinoma
NCT06332092Head and Neck Squamous Cell Carcinoma
Fulgent Pharma LLC.
Phase 2
46
Arkansas, California, Florida, Indiana, Texas
2024-04-10
Active, closed
A Study of TAR-200 Versus Intravesical Chemotherapy in Participants With Recurrent High-Risk Non-Muscle-Invasive Bladder Cancer (HR-NMIBC) After Bacillus Calmette-Guérin (BCG)
NCT06211764Non-Muscle Invasive Bladder Neoplasms
DrugsTAR-200·Mitomycin C·Gemcitabine
Janssen Research & Development, LLC
Phase 3
272
Arkansas, California, Colorado, Florida, Illinois, Indiana, Kansas, Michigan
2024-04-09
Recruiting
BostonGene and Exigent Genomic INsight Study
NCT06272864Breast Cancer, Non-small Cell Lung Cancer, Melanoma, Sarcoma
BostonGene
Observational
400
Arkansas, California, Indiana, New Mexico, Oklahoma, Texas, Washington
2024-04-08
Recruiting
Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Adults With Moderate to Severe Acne
NCT06316297Acne
DrugAcne mRNA vaccine
Sanofi Pasteur, a Sanofi Company
Phase 1/2
800
Arizona, California, Florida, Georgia, Illinois, Indiana, Iowa, Kentucky
2024-04-05
Active, closed
AAA-SHAPE Pivotal Trial: Abdominal Aortic Aneurysm Sac Healing and Prevention of Expansion
NCT06029660Aortic Aneurysm, Abdominal
Shape Memory Medical, Inc.
Not applicable
180
Alabama, Arizona, California, Florida, Georgia, Illinois, Indiana, Maine
2024-04-05
Recruiting
Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors
NCT06276491Ovarian Cancer, Endometrial Cancer, Germ Cell Tumor, Testicular Germ Cell Tumor
DrugXmAb541
Xencor, Inc.
Phase 1
282
California, Florida, Georgia, Illinois, Indiana, Michigan, Minnesota, New Jersey
2024-04-04
Recruiting
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
NCT06312137Non Small Cell Lung Cancer
DrugsSacituzumab tirumotecan·Pemetrexed·Gemcitabine·Paclitaxel
Merck Sharp & Dohme LLC
Phase 3
780
Arkansas, California, Connecticut, Florida, Georgia, Illinois, Indiana, Kentucky
2024-04-03
Active, closed
RRx-001 for Reducing Oral Mucositis in Patients Receiving Chemotherapy and Radiation for Head and Neck Cancer
NCT05966194Oral Mucositis
DrugsRRx-001·Cisplatin
EpicentRx, Inc.
Phase 2
216
Arizona, Florida, Illinois, Indiana, Louisiana, Maryland, Michigan, Nevada
2024-04-02
Active, closed
Copper Cu 64 PSMA I&T PET Imaging in Men With Newly Diagnosed Prostate Cancer
NCT06235151Prostate Cancer, Prostate Adenocarcinoma
Curium US LLC
Phase 3
439
Alabama, Arkansas, California, District of Columbia, Florida, Illinois, Indiana, Iowa
2024-04-01
Recruiting
Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Undergoing Cardiac Surgery
NCT06271265Postoperative Pain
DrugsExparel·Bupivacaine
Pacira Pharmaceuticals, Inc
Phase 1
48
Indiana, Missouri, North Carolina, Oklahoma, Texas
2024-03-29
Active, closed
A Study to Assess Adverse Events and Change in Disease Activity From Intravenous (IV) and Subcutaneous (SC) Lutikizumab in Adult Participants With Active Ulcerative Colitis
NCT06257875Ulcerative Colitis
DrugsLutikizumab·Humira·Adalimumab
AbbVie
Phase 2
156
California, Colorado, Florida, Georgia, Illinois, Indiana, Kansas, Louisiana
2024-03-23
Recruiting
A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma
NCT06256588Neoplasms, Head and Neck
DrugDostarlimab
GlaxoSmithKline
Phase 3
864
Arkansas, California, Connecticut, District of Columbia, Florida, Georgia, Indiana, Iowa
2024-03-21
Active, closed
Iltamiocel Compared to Placebo for Chronic Fecal Incontinence in Females With Obstetric Injury
NCT05776277Fecal Incontinence
DrugIltamiocel
Cook MyoSite
Phase 3
200
California, Florida, Georgia, Illinois, Indiana, Louisiana, Massachusetts, Michigan
2024-03-21
Recruiting
Evaluation of SPN-812 (Viloxazine Extended-release Capsule) in Preschool-age Children With ADHD
NCT04781140Attention-Deficit/Hyperactivity Disorder
DrugViloxazine
Supernus Pharmaceuticals, Inc.
Phase 4
286
Alabama, Arkansas, California, Colorado, Florida, Georgia, Indiana, Kentucky
2024-03-19
Recruiting
A Phase 1 of CTX-8371 in Patients With Advanced Malignancies
NCT06150664Non Small Cell Lung Cancer, Triple Negative Breast Cancer, Hodgkin Lymphoma, Head and Neck Squamous Cell Carcinoma
Compass Therapeutics
Phase 1
85
Florida, Georgia, Indiana, Massachusetts, New York, Tennessee, Washington
2024-03-19
Active, closed
A Clinical Trial Evaluating the Safety and Efficacy of a Single Subretinal Injection of AGTC-501 in Participants With XLRP
NCT04850118X-Linked Retinitis Pigmentosa
DrugAGTC-501
Beacon Therapeutics
Phase 2/3
85
Arizona, California, Florida, Indiana, Maryland, Massachusetts, Minnesota, North Carolina
2024-03-14
Recruiting
A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease
NCT05923073Crohn's Disease
DrugsTremfya·Guselkumab
Janssen Research & Development, LLC
Phase 3
120
California, Connecticut, Georgia, Indiana, Massachusetts, New Jersey, New York, Ohio
2024-03-13
Recruiting
A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease
NCT05509777Crohn's Disease
DrugMirikizumab
Eli Lilly and Company
Phase 3
90
California, Connecticut, Georgia, Indiana, Massachusetts, New Jersey, New York, Ohio
2024-03-13
Recruiting
Tracking Results of Ablations to Combat AF Registry Generation 2
NCT05111015Atrial Fibrillation
AtriCure, Inc.
Observational
10,000
Alabama, Arkansas, California, Colorado, District of Columbia, Florida, Indiana, Kansas
2024-03-11
Active, closed
Clinical Utility of Neurophysiological Measurements of ECAP-controlled Closed-loop SCS to Guide Treatment of Chronic Pain
NCT06229470Chronic Pain
Saluda Medical Pty Ltd
Not applicable
250
Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana, Iowa
2024-03-08
Recruiting
A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events
NCT06112418Diabetes Mellitus, Type 2, PreDiabetes, Metabolic Syndrome
Cleerly, Inc.
Not applicable
7,500
Arizona, California, Colorado, Florida, Georgia, Idaho, Illinois, Indiana
2024-03-06
Recruiting
A Study of Sepiapterin in Participants With Phenylketonuria (PKU)
NCT06302348Phenylketonuria
PTC Therapeutics
Phase 3
56
Indiana
2024-03-04
Recruiting
Study to Learn About the Safety of Fazirsiran and if it Can Help People With Alpha-1 Antitrypsin Liver Disease With Mild Liver Scarring (Fibrosis)
NCT06165341Alpha1-Antitrypsin Deficiency
DrugFazirsiran
Takeda
Phase 3
50
Arizona, California, Colorado, Florida, Indiana, Iowa, Massachusetts, Michigan
2024-03-01
Active, closed
A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab on Background Topical Corticosteroids Therapy in Participants Aged 12 Years and Older With Moderate-to-severe AD Who Have Had an Inadequate Response to Prior Biologic Therapy or an Oral JAK Inhibitor
NCT06241118Dermatitis Atopic
DrugsPimecrolimus·Amlitelimab·Tacrolimus
Sanofi
Phase 3
464
Alabama, Arizona, Arkansas, California, Colorado, Florida, Illinois, Indiana
2024-02-29
Recruiting
A Study of Raludotatug Deruxtecan (R-DXd) in Subjects With Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
NCT06161025Solid Cancer
DrugsR-DXd·Topotecan·Paclitaxel
Daiichi Sankyo
Phase 2/3
860
Alaska, Connecticut, Florida, Indiana, Kentucky, Massachusetts, Missouri, New Jersey
2024-02-27
Active, closed
VIA Disc NP Registry 3.0
NCT06345690Discogenic Pain, Back Pain, Back Pain, Low
VIVEX Biologics, Inc.
Observational
500
Arkansas, Colorado, Florida, Georgia, Indiana, Louisiana, North Carolina, Oklahoma
2024-02-27
Active, closed
Study of Onvansertib in Combination With FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab Versus FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer in Adult Participants With a KRAS or NRAS Mutation
NCT06106308Metastatic Colorectal Cancer, CRC, KRAS/NRAS Mutation
DrugsOnvansertib·Folfiri·Folfox·Bevacizumab
Cardiff Oncology
Phase 2
110
Arizona, Arkansas, California, Florida, Hawaii, Indiana, Kansas, Michigan
2024-02-27
Active, closed
CLIP-IT Post-Market Study
NCT06203054Left Atrial Appendage Exclusion
Medtronic Cardiac Surgery
Not applicable
198
Georgia, Illinois, Indiana, Michigan, Minnesota, Missouri, New York, Ohio
2024-02-26
Active, closed
Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)
NCT06260722Diabetes Mellitus, Type 2
DrugsRetatrutide·Semaglutide
Eli Lilly and Company
Phase 3
1,250
Alabama, California, Colorado, Florida, Georgia, Hawaii, Idaho, Indiana
2024-02-21
Active, closed
A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135) and Iberdomide in Patients With Relapsed or Refractory Multiple Myeloma (MagnetisMM-30)
NCT06215118Multiple Myeloma
DrugsIberdomide·Elranatamab
Pfizer
Phase 1
100
Florida, Georgia, Indiana, Maryland, Massachusetts, Nebraska, New Hampshire, New Jersey
2024-02-20
Active, closed
Persona IQ Cohort Study
NCT06089291Osteo Arthritis Knee, Knee Arthritis, Monitoring Orthopedic Devices, Total Knee Arthroplasty
Zimmer Biomet
Observational
200
Indiana, Missouri, North Carolina, Pennsylvania
2024-02-20
Recruiting
A Global Prospective Observational Registry of Patients With Pompe Disease
NCT06121011Pompe Disease
DrugsAlglucosidase alfa·Cipaglucosidase alfa·Miglustat·Avalglucosidase alfa
Amicus Therapeutics
Observational
500
Arkansas, California, Florida, Georgia, Indiana, Missouri, New York, North Carolina
2024-02-16
Recruiting
A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors
NCT06244771Advanced Solid Tumors With KRAS G12C Mutations, Solid Tumor, Adult, Unresectable Solid Tumor, Metastatic Solid Tumor
Frontier Medicines Corporation
Phase 1/2
403
California, Florida, Indiana, Kansas, Massachusetts, Michigan, Pennsylvania, Texas
2024-02-12
Recruiting
MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)
NCT06152575Multiple Myeloma
DrugsElotuzumab·Elranatamab·Carfilzomib·Pomalidomide
Pfizer
Phase 3
492
Alabama, Arizona, California, Colorado, Florida, Illinois, Indiana, Kansas
2024-02-08
Recruiting
A Study of Alisertib in Patients With Extensive Stage Small Cell Lung Cancer
NCT06095505Small Cell Lung Cancer
DrugAlisertib
Puma Biotechnology, Inc.
Phase 2
120
Alabama, California, Colorado, District of Columbia, Florida, Illinois, Indiana, Maryland
2024-02-08
Recruiting
A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis
NCT06072482Antineutrophil Cytoplasmic Antibody-associated Vasculitis
DrugAvacopan
Amgen
Phase 4
300
Alaska, Arizona, Arkansas, California, Colorado, Florida, Georgia, Indiana
2024-02-07
By invitation
An Observational Study Comparing Delandistrogene Moxeparvovec (ELEVIDYS) With Standard of Care in Participants With Duchenne Muscular Dystrophy
NCT06270719Duchenne Muscular Dystrophy
Sarepta Therapeutics, Inc.
Observational
500
Arkansas, California, Colorado, Connecticut, District of Columbia, Florida, Illinois, Indiana
2024-02-07
Recruiting
Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Subjects With Corneal Scars
NCT06257355Corneal Scar
DrugCSB-001 Ophthalmic
Claris Biotherapeutics, Inc.
Phase 1
20
California, Indiana, Minnesota, Oregon, Texas, Virginia
2024-02-05
Recruiting
Study of Olverembatinib (HQP1351) in Patients With CML-CP
NCT06423911Chronic Myeloid Leukemia, CML, CML, Chronic Phase
DrugsBosutinib·Olverembatinib
Ascentage Pharma Group Inc.
Phase 3
333
Alabama, Alaska, Arizona, California, Georgia, Illinois, Indiana, Kansas
2024-02-05
Active, closed
Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Previously Untreated Follicular Lymphoma
NCT06191744Follicular Lymphoma (FL)
DrugsEpcoritamab·Bendamustine·Obinutuzumab·Vincristine
Genmab
Phase 3
1,095
California, Colorado, Delaware, Florida, Idaho, Illinois, Indiana, Iowa
2024-02-05
Recruiting
Oral Ifetroban in Patients With Idiopathic Pulmonary Fibrosis (IPF)
NCT05571059Idiopathic Pulmonary Fibrosis
DrugIfetroban
Cumberland Pharmaceuticals
Phase 2
128
California, Connecticut, Florida, Illinois, Indiana, Kansas, Kentucky, Michigan
2024-01-31
Active, closed
A Study to Evaluate the Long-Term Safety and Efficacy of Povorcitinib in Participants With Moderate to Severe Hidradenitis Suppurativa
NCT06212999Hidradenitis Suppurativa (HS)
DrugPovorcitinib
Incyte Corporation
Phase 3
617
Arizona, Arkansas, California, Florida, Georgia, Illinois, Indiana, Kentucky
2024-01-30
Recruiting
Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM
NCT05902169Glioblastoma, Recurrent Glioblastoma, GBM
DrugsLomustine·Temodal·Temozolomide·Carboplatin
CarThera
Phase 3
560
Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana, Maryland
2024-01-29
Active, closed
Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Ocular Therapeutix) (Axitinib Implant) in Subjects With Neovascular Age-Related Macular Degeneration
NCT06223958Neovascular Age-Related Macular Degeneration
DrugsOtx-Tki·Aflibercept
Ocular Therapeutix, Inc.
Phase 3
344
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana
2024-01-29
Active, closed
Registry of the Patient Experience for Carpal Tunnel Release
NCT06071468Carpal Tunnel Syndrome, CTS
Sonex Health, Inc.
Observational
1,424
Alabama, Arizona, Connecticut, Florida, Indiana, Massachusetts, Michigan, Minnesota
2024-01-26
Recruiting
Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder
NCT06229210Schizophrenia, Bipolar Disorder, Autism Spectrum Disorder
DrugLumateperone
Intra-Cellular Therapies, Inc.
Phase 3
300
Arizona, Arkansas, California, Colorado, Florida, Georgia, Illinois, Indiana
2024-01-25
Active, closed
A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.
NCT06143891Chronic Graft Versus Host Disease
DrugsBelumosudil·Prednisolone·Prednisone
Sanofi
Phase 3
260
Arkansas, California, Florida, Georgia, Illinois, Indiana, Kentucky, Maryland
2024-01-23
Recruiting
A Long Term, Post-marketing Study of Immune Response in Patients Receiving Palynziq Treatment for PKU (PALisade)
NCT06305234Phenylketonuria (PKU)
DrugPegvaliase
BioMarin Pharmaceutical
Observational
200
Colorado, Georgia, Illinois, Indiana, Louisiana, Massachusetts, Oregon, Pennsylvania
2024-01-20
Recruiting
A Double Blind, Randomized Controlled Study, Evaluating the Safety and Efficacy of RD2 Ver.02 For the Management of Anal Fistulas
NCT05641844Anal Fistula
RedDress Ltd.
Not applicable
110
California, Florida, Illinois, Indiana, Massachusetts, Minnesota, New York, Pennsylvania
2024-01-20
Active, closed
A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis
NCT06260163Colitis, Ulcerative
DrugsTremfya·Guselkumab
Janssen Research & Development, LLC
Phase 3
112
California, Indiana, New York
2024-01-19
Active, closed
A 52-Week Study to Learn About the Safety and Effects of Ritlecitinib in Participants With Nonsegmental Vitiligo
NCT06163326Vitiligo
DrugRitlecitinib
Pfizer
Phase 3
394
California, Florida, Indiana, Louisiana, Maryland, Michigan, New Mexico, New York
2024-01-19
Active, closed
A Study of DB-1303/BNT323 vs Investigator's Choice Chemotherapy in HER2-Low, Hormone Receptor Positive Metastatic Breast Cancer (DYNASTY-Breast02)
NCT06018337Metastatic Breast Cancer
DrugsDB-1303/BNT323·Nab-paclitaxel·Capecitabine·Paclitaxel
DualityBio Inc.
Phase 3
541
Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana, Kansas
2024-01-18
Active, closed
A Trial That Evaluates Disease Characteristics in Hemophilia B Adult Male Participants Receiving Prophylaxis With Standard of Care Factor IX Protein (FIX) Replacement Therapy
NCT05568459Hemophilia B
Regeneron Pharmaceuticals
Observational
11
Colorado, Connecticut, District of Columbia, Florida, Illinois, Indiana, Michigan, Ohio
2024-01-17
Active, closed
A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis
NCT06143878Plaque Psoriasis
DrugsIcotrokinra·Deucravacitinib
Janssen Research & Development, LLC
Phase 3
774
Arizona, Arkansas, California, Florida, Georgia, Illinois, Indiana, Kentucky
2024-01-17
Active, closed
Study of ALXN2220 Versus Placebo in Adults With ATTR-CM
NCT06183931Transthyretin Amyloid Cardiomyopathy
DrugCliramitug
Alexion Pharmaceuticals, Inc.
Phase 3
1,181
California, Colorado, District of Columbia, Florida, Georgia, Illinois, Indiana, Massachusetts
2024-01-11
Active, closed
LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF
NCT05983250Pulmonary Hypertension
DrugTNX-103
Tenax Therapeutics, Inc.
Phase 3
230
Arizona, California, Florida, Georgia, Illinois, Indiana, Kentucky, Massachusetts
2024-01-10
Active, closed
A Phase II Study of AAA617 Alone and AAA617 in Combination With ARPI in Patients With PSMA PET Scan Positive CRPC
NCT05849298Prostatic Neoplasm
DrugsARPI·Pylarify·Illuccix·Lu-PSMA
Novartis Pharmaceuticals
Phase 2
49
Colorado, Georgia, Indiana, Iowa, Nebraska, Oregon, Pennsylvania, Texas
2024-01-03
Active, closed
Phase 3 Study of ALXN1850 Versus Placebo in Adolescent and Adult Participants With HPP Who Have Not Previously Been Treated With Asfotase Alfa
NCT06079281Hypophosphatasia
DrugALXN1850
Alexion Pharmaceuticals, Inc.
Phase 3
124
Indiana, New York, North Carolina, Ohio, Tennessee
2024-01-03
Active, closed
Effect of Naltrexone Hydrochloride ER and Bupropion Hydrochloride ER Combination (Contrave®/Mysimba®) on Major Adverse Cardiovascular Events (MACE)
NCT06098079Obesity
Currax Pharmaceuticals
Phase 4
8,600
Alabama, Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana
2024-01-03
Recruiting
SAVE-FistulaS: the SelfWrap-Assisted ArterioVEnous Fistulas Study
NCT06001827Chronic Kidney Diseases, End Stage Renal Disease, Arteriovenous Fistula, Hemodialysis Access Failure
VenoStent
Not applicable
600
Arizona, California, Florida, Indiana, Kentucky, Massachusetts, Minnesota, Missouri
2024-01-03
Recruiting
An Open-Label ProSpective MultiCENTer Study to Evaluate Safety and Tolerability of Dry Powder Inhaled Treprostinil in PH
NCT06129240Pulmonary Hypertension, Interstitial Lung Disease
Liquidia Technologies, Inc.
Observational
80
Arizona, California, Colorado, Connecticut, Florida, Indiana, Kentucky, Massachusetts
2023-12-28
Active, closed
Pulsed Field Ablation (PFA) vs Anti-Arrhythmic Drug (AAD) Therapy as a First Line Treatment for Persistent Atrial Fibrillation
NCT06096337Persistent Atrial Fibrillation
Boston Scientific Corporation
Not applicable
484
Alabama, Arizona, Arkansas, California, Florida, Georgia, Illinois, Indiana
2023-12-28
Recruiting
A Trial to Find Out if Odronextamab Combined With Lenalidomide is Safe and Works Better Than Rituximab Combined With Lenalidomide in Adult Participants With Follicular Lymphoma and Marginal Zone Lymphoma
NCT06149286Relapsed/Refractory Follicular Lymphoma, Relapsed/Refractory Marginal Zone Lymphoma (R/R MZL)
DrugsOdronextamab·Lenalidomide·Rituximab
Regeneron Pharmaceuticals
Phase 3
580
California, Florida, Indiana, Mississippi, New Hampshire, New York, Wisconsin
2023-12-28
Recruiting
Study to Evaluate the Safety of CG-P5 Peptide Eye Drops in Patients Diagnosed With Age-related Wet Macular Degeneration
NCT06132035Age-related Wet Macular Degeneration
DrugsEylea·Aflibercept
Caregen Co. Ltd.
Phase 1
45
Connecticut, Florida, Georgia, Indiana, North Dakota, Pennsylvania
2023-12-22
Recruiting
Positron Emission Tomography Using 64Cu-SAR-bisPSMA in Participants With High-risk Prostate Cancer Prior to Radical Prostatectomy
NCT06056830Prostate Cancer, Prostatic Neoplasms
Drug64Cu-SAR-bisPSMA
Clarity Pharmaceuticals Ltd
Phase 3
383
Alabama, Arizona, Arkansas, California, Florida, Illinois, Indiana, Kansas
2023-12-21
Recruiting
A Study of Nipocalimab in Pregnancies at Risk for Severe Hemolytic Disease of the Fetus and Newborn (HDFN)
NCT05912517Hemolytic Disease of the Fetus and Newborn
DrugNipocalimab
Janssen Research & Development, LLC
Phase 3
120
California, Colorado, Florida, Illinois, Indiana, Iowa, Kentucky, Maryland
2023-12-20
Recruiting
A Study of LM-24C5 For Advanced Solid Tumors
NCT06187402Advanced Solid Tumor
DrugLM-24C5
LaNova Medicines Limited
Phase 1/2
49
California, Florida, Indiana, Ohio, Texas, Virginia
2023-12-20
Active, closed
A Study To Assess Adverse Events and Effectiveness of Upadacitinib Oral Tablets in Adult and Adolescent Participants With Vitiligo
NCT06118411Vitiligo
DrugUpadacitinib
AbbVie
Phase 3
614
Arizona, California, Florida, Georgia, Illinois, Indiana, Massachusetts, Michigan
2023-12-19
Recruiting
A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)
NCT06136559Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
DrugsNemtabrutinib·Ibrutinib·Acalabrutinib
Merck Sharp & Dohme LLC
Phase 3
1,200
Alabama, Arizona, California, Colorado, Connecticut, Florida, Idaho, Indiana
2023-12-13
Recruiting
A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell Lymphoma
NCT06091865Diffuse Large B-cell Lymphoma (DLBCL)
DrugsOdronextamab·Prednisone/Prednisolone·Adriamycin·Cytoxan
Regeneron Pharmaceuticals
Phase 3
904
Arizona, California, Florida, Indiana, Kentucky, Maryland, Massachusetts, Michigan
2023-12-13
Recruiting
A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Adult Participants With Previously Untreated Follicular Lymphoma
NCT06091254Follicular Lymphoma (FL)
DrugsOdronextamab·Prednisone/Prednisolone·Adriamycin·Bendamustine
Regeneron Pharmaceuticals
Phase 3
822
Arizona, California, Indiana, Massachusetts, Michigan, Mississippi, New York, North Carolina
2023-12-12
Recruiting
A Study to Assess Adverse Events, Change in Disease Activity, and How Intravenous and Subcutaneous Risankizumab Moves Through the Body of Pediatric Participants With Moderately to Severely Active Crohn's Disease
NCT05995353Crohn's Disease
DrugsSkyrizi·Risankizumab
AbbVie
Phase 3
110
Arizona, Arkansas, California, Colorado, Florida, Indiana, Massachusetts, Minnesota
2023-12-11
Recruiting
Zenith® Fenestrated+ Clinical Study
NCT04875429Aortic Aneurysm, Abdominal, Juxtarenal Aortic Aneurysm, Extent IV Thoracoabdominal, Pararenal Aneurysm
Cook Research Incorporated
Not applicable
105
Alabama, California, District of Columbia, Florida, Georgia, Illinois, Indiana, Maryland
2023-12-08
Recruiting
Phase II Study of Artesunate Ointment for the Treatment of Vulvar High Grade Squamous Intraepithelial Lesions (Vulvar HSIL, VIN2/3)
NCT06075264Vulvar Diseases, HPV Infection, Vulvar HSIL, Pre-Cancerous Dysplasia
DrugArtesunate
Frantz Viral Therapeutics, LLC
Phase 2
27
Florida, Indiana, Ohio
2023-12-06
Recruiting
Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.
NCT06072612Breast Cancer, Metastatic Breast Cancer, Breast Neoplasm, Breast Cancer Metastatic
DrugsRetifanlimab·Cyclophosphamide
BriaCell Therapeutics Corporation
Phase 3
404
Arizona, California, Connecticut, Florida, Georgia, Illinois, Indiana, Kansas
2023-12-05
Active, closed
Efficacy/Safety of ALTB-268 in Subjects w/Moderately to Severely Active UC Refractory to Biologics
NCT06109441Ulcerative Colitis
DrugALTB-268
AltruBio Inc.
Phase 2
50
California, Colorado, Florida, Indiana, Kentucky, Louisiana, Mississippi, New York
2023-12-04
Recruiting
PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
NCT05934487Heart Failure NYHA Class II, Heart Failure NYHA Class III, Heart Failure
Endotronix, Inc.
Not applicable
1,750
Arizona, California, Florida, Georgia, Illinois, Indiana, Kansas, Maryland
2023-11-29
Active, closed
A Study to Evaluate Efficacy and Safety of Povorcitinib in Participants With Nonsegmental Vitiligo (STOP-V1)
NCT06113445NonSegmental Vitiligo
DrugPovorcitinib
Incyte Corporation
Phase 3
467
Alabama, California, Florida, Georgia, Indiana, Massachusetts, Michigan, Missouri
2023-11-29
Active, closed
A Study to Evaluate Efficacy and Safety of Povorcitinib in Participants With Nonsegmental Vitiligo (STOP-V2)
NCT06113471NonSegmental Vitiligo
DrugPovorcitinib
Incyte Corporation
Phase 3
450
Alabama, California, Florida, Georgia, Illinois, Indiana, Louisiana, Maryland
2023-11-27
Recruiting
A Surveillance Study of Susceptibility to Baloxavir Marboxil in Pediatric Participants With Influenza and Transmission of Influenza to Household Contacts
NCT06094010Influenza
DrugBaloxavir Marboxil
Hoffmann-La Roche
Phase 3
1,100
Alabama, Arkansas, Florida, Georgia, Idaho, Indiana, Kentucky, Louisiana
2023-11-22
Active, closed
Saruparib (AZD5305) vs Placebo in Men With Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents
NCT06120491Metastatic Castration-Sensitive Prostate Cancer
DrugsSaruparib·Zytiga·Xtandi·Abiraterone acetate
AstraZeneca
Phase 3
1,898
Arizona, Arkansas, California, Colorado, Connecticut, Georgia, Illinois, Indiana
2023-11-21
Active, closed
Retrospective Observational Study of Patients Who Have Undergone Coronary Artery Bypass Graft (CABG) and/or Cardiac Valve Surgery
NCT07009340Post-discharge Outcomes
Renibus Therapeutics, Inc.
Observational
200
Alabama, Indiana, Michigan, Texas
2023-11-18
Recruiting
uTRACT Jelmyto Registry: A Registry of Patients With Upper Tract Urothelial Cancer (UTUC) Treated With Jelmyto
NCT05874921Urothelial Carcinoma, Urothelial Carcinoma Recurrent, Urothelial Carcinoma Ureter, Urothelial Carcinoma Ureter Recurrent
DrugMitomycin C
UroGen Pharma Ltd.
Observational
450
California, Florida, Illinois, Indiana, Iowa, Maryland, Massachusetts, Michigan
2023-11-17
Active, closed
A Phase 2b Study to Evaluate Rezpegaldesleukin (Rezpeg) in the Treatment of Adult Patients With Moderate-to-Severe Atopic Dermatitis
NCT06136741Moderate to Severe Atopic Dermatitis
DrugRezpegaldesleukin
Nektar Therapeutics
Phase 2
396
Arkansas, California, Florida, Georgia, Indiana, Kentucky, Michigan, Nevada
2023-11-15
Active, closed
A Study to Assess Adverse Events and Change in Disease Activity of Risankizumab Subcutaneous Induction Treatment for Moderately to Severely Active Crohn's Disease.
NCT06063967Crohn's Disease
DrugsSkyrizi·Risankizumab
AbbVie
Phase 3
289
Arizona, California, Connecticut, Florida, Georgia, Idaho, Illinois, Indiana
2023-11-15
Active, closed
A Trial to Learn if Odronextamab Combined With Chemotherapy is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Chemotherapy for Adult Participants With Follicular Lymphoma
NCT06097364Follicular Lymphoma (FL)
DrugsOdronextamab·Prednisone/Prednisolone·Adriamycin·Cytoxan
Regeneron Pharmaceuticals
Phase 3
733
Florida, Indiana, Kansas, Kentucky, Michigan, Texas, Utah, Wisconsin
2023-11-14
Recruiting
Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
NCT06128551Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer, Pancreatic Ductal Adenocarcinoma
DrugsElironrasib·Cetuximab
Revolution Medicines, Inc.
Phase 1/2
534
California, Colorado, Florida, Indiana, Massachusetts, Michigan, New York, Oklahoma
2023-11-14
Active, closed
Study to Assess Adverse Events and Change in Disease Activity in Previously Treated Adult Participants Receiving Intravenous (IV) ABBV-400 With Unresectable Metastatic Colorectal Cancer in Combination With IV Fluorouracil, Folinic Acid, and Bevacizumab
NCT06107413Unresectable Metastatic Colorectal Cancer
DrugsFolinic acid·Telisotuzumab Adizutecan·Fluorouracil·Irinotecan
AbbVie
Phase 2
280
Arizona, Arkansas, California, Connecticut, Florida, Illinois, Indiana, Louisiana
2023-11-12
Active, closed
Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Participants With Chronic Lymphocytic Leukemia (CLL)
NCT06073821CLL
DrugsSonrotoclax·Zanubrutinib·Obinutuzumab·Venetoclax
BeOne Medicines
Phase 3
652
Alaska, California, Colorado, District of Columbia, Florida, Georgia, Illinois, Indiana
2023-11-11
Active, closed
A Study Evaluating Efruxifermin in Subjects With Non-invasively Diagnosed Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Nonalcoholic Fatty Liver Disease (NAFLD)/Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
NCT06161571NASH/MASH, NAFLD/MASLD
DrugEfruxifermin
Akero Therapeutics, Inc
Phase 3
700
Alabama, Arizona, Arkansas, California, Colorado, Florida, Georgia, Indiana
2023-11-10
Active, closed
A 104-Week Study of Ritlecitinib Oral Capsules in Adults With Nonsegmental Vitiligo (Active and Stable) Tranquillo 2
NCT06072183Stable Nonsegmental Vitiligo, Active Nonsegmental Vitiligo
DrugRitlecitinib
Pfizer
Phase 3
1,571
Arizona, Arkansas, California, Florida, Georgia, Illinois, Indiana, Maryland
2023-11-08
Active, closed
Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
NCT06122779Heart Failure
DrugBMS-986435
Bristol-Myers Squibb
Phase 2
227
Alabama, Colorado, Florida, Illinois, Indiana, Missouri, New Jersey, New York
2023-11-07
Recruiting
Safety, PK, and Preliminary Efficacy of MBRC-101 in Advanced Refractory Solid Tumors
NCT06014658Cancer
MBrace Therapeutics
Phase 1/2
130
California, Colorado, Georgia, Illinois, Indiana, Michigan, Nevada, New Jersey
2023-11-07
By invitation
Open-Label Extension of EDG-5506 in Participants With Becker Muscular Dystrophy
NCT06066580Becker Muscular Dystrophy
Edgewise Therapeutics, Inc.
Phase 2
260
Arkansas, California, Colorado, Florida, Georgia, Illinois, Indiana, Iowa
2023-11-02
Active, closed
A Study to Evaluate ABP 206 Compared With OPDIVO® (Nivolumab) in Subjects With Unresectable or Metastatic Melanoma
NCT06054555Melanoma
DrugsOpdivo·Nivolumab
Amgen
Phase 3
633
California, Indiana, Louisiana, Missouri, New York
2023-11-02
Active, closed
Safety and Tolerability of OCU-10-C-110 for Injection in Subjects With Neovascular Age-related Macular Degeneration
NCT05904691Neovascular Age-related Macular Degeneration (nAMD)
Ocugenix Corporation
Phase 1
24
Indiana, Texas
2023-11-01
Recruiting
A Study Assessing KB707 for the Treatment of Locally Advanced or Metastatic Solid Tumors
NCT05970497Cancer, Melanoma Stage III, Melanoma Stage IV, Cutaneous Melanoma
DrugsKB707·Opdualag·Keytruda·Pembrolizumab
Krystal Biotech, Inc.
Phase 1/2
240
California, Florida, Indiana, Michigan, Nebraska, New Jersey, New York, Ohio
2023-10-31
Active, closed
A Global Study of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for Participants With Metastatic Non-small Cell Lung Cancer.
NCT05984277Metastatic Non-small Cell Lung Cancer
DrugsVolrustomig·Pemetrexed·Paclitaxel·Carboplatin
AstraZeneca
Phase 3
895
Arkansas, California, Colorado, Florida, Indiana, Iowa, Kentucky, Maryland
2023-10-24
Active, closed
ELEMENT-MDS: A Study to Compare the Efficacy and Safety of Luspatercept in Participants With Myelodysplastic Syndrome (MDS) and Anemia Not Receiving Blood Transfusions
NCT05949684Myelodysplastic Syndromes
DrugsEpoetin Alfa·Reblozyl·Luspatercept
Bristol-Myers Squibb
Phase 3
402
California, Connecticut, Florida, Hawaii, Illinois, Indiana, Louisiana, Maryland
2023-10-24
Recruiting
A Study to Evaluate Glofitamab as a Single Agent vs. Investigator's Choice in Participants With Relapsed/Refractory Mantle Cell Lymphoma
NCT06084936Lymphoma
DrugsGlofitamab·Bendamustine·Tocilizumab·Obinutuzumab
Hoffmann-La Roche
Phase 3
182
California, Connecticut, District of Columbia, Florida, Indiana, Iowa, Michigan, Missouri
2023-10-22
Active, closed
Safety and Tolerability of GTX-104 Compared with Oral Nimodipine in Patients with ASAH
NCT05995405Aneurysmal Subarachnoid Hemorrhage (aSAH)
DrugNimotop
Grace Therapeutics Inc.
Phase 3
100
Alabama, Arizona, California, Florida, Georgia, Illinois, Indiana, Kentucky
2023-10-20
Active, closed
Nerve Protection Evaluation: Revision Cubital Tunnel Syndrome Decompression
NCT06117501Recurrent Cubital Tunnel Syndrome, Recalcitrant Cubital Tunnel Syndrome
Axogen Corporation
Not applicable
20
Florida, Georgia, Indiana, New Mexico, Ohio, Pennsylvania, Utah
2023-10-19
Active, closed
A Study of the Efficacy and Safety of Adjuvant Autogene Cevumeran Plus Atezolizumab and mFOLFIRINOX Versus mFOLFIRINOX Alone in Participants With Resected PDAC
NCT05968326Adenocarcinoma, Pancreatic Ductal
DrugsAutogene cevumeran·MFOLFIRINOX·Tecentriq·Atezolizumab
Genentech, Inc.
Phase 2
260
California, Connecticut, Illinois, Indiana, Kentucky, Massachusetts, Michigan, Nebraska
2023-10-18
Recruiting
A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer
NCT05902988Advanced Solid Tumor, High Grade Serous Adenocarcinoma of Ovary, Squamous Non-small-cell Lung Cancer, Triple Negative Breast Cancer
Volastra Therapeutics, Inc.
Phase 1/2
200
California, Colorado, Connecticut, Illinois, Indiana, Maryland, Michigan, New York
2023-10-18
Recruiting
DAREON™-5: A Study to Test Whether Different Doses of BI 764532 Help People With Small Cell Lung Cancer or Other Neuroendocrine Cancers
NCT05882058Small Cell Lung Carcinoma, Neuroendocrine Neoplasms, Extra-pulmonary Neuroendocrine Carcinoma
DrugObrixtamig
Boehringer Ingelheim
Phase 2
204
Alabama, Arizona, California, Florida, Indiana, Kansas, Kentucky, Maryland
2023-10-13
Active, closed
A Study of JNJ-77242113 in Adolescent and Adult Participants With Moderate to Severe Plaque Psoriasis
NCT06095115Plaque Psoriasis
DrugIcotrokinra
Janssen Research & Development, LLC
Phase 3
684
Arizona, Arkansas, California, Florida, Georgia, Illinois, Indiana, Kentucky
2023-10-12
Active, closed
A Study of JNJ-77242113 for the Treatment of Participants With Plaque Psoriasis Involving Special Areas (Scalp, Genital, and/or Palms of the Hands and the Soles of the Feet)
NCT06095102Plaque Psoriasis
DrugIcotrokinra
Janssen Research & Development, LLC
Phase 3
311
Arizona, Arkansas, California, Florida, Georgia, Illinois, Indiana, Louisiana
2023-10-12
Recruiting
A Study to Evaluate the Safety and Effectiveness of Upadacitinib Tablets in Adult and Adolescent Participants With Severe Alopecia Areata
NCT06012240Alopecia Areata
DrugUpadacitinib
AbbVie
Phase 3
1,500
Alabama, Arizona, Arkansas, California, Florida, Georgia, Illinois, Indiana
2023-10-11
Recruiting
Metastatic Castrate-Resistant Prostate Cancer Subjects Treated With PROVENGE® + One Infusion of Sipuleucel-T
NCT06134232Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Dendreon
Phase 2
400
Arizona, California, Colorado, Florida, Illinois, Indiana, Maryland, Michigan
2023-10-02
Active, closed
A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Episodic Migraine in Adults
NCT06047457Episodic Migraine
DrugsDysport·Botulinum toxin type A
Ipsen
Phase 3
751
Alabama, Arizona, California, Connecticut, Florida, Illinois, Indiana, Maryland
2023-09-29
Recruiting
Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Budesonide Extended-release Tablets in Pediatric Subjects Aged 5 to 17 Years With Active, Mild to Moderate Ulcerative Colitis
NCT04314375Ulcerative Colitis
DrugBudesonide
Bausch Health Americas, Inc.
Phase 4
70
California, Indiana, New York, North Carolina
2023-09-29
Active, closed
First in Human Study of TORL-3-600 in Participants With Advanced Cancer
NCT05948826Advanced Solid Tumor, Colorectal Cancer
TORL Biotherapeutics, LLC
Phase 1
70
California, Colorado, Indiana, Missouri, Tennessee, Texas
2023-09-29
Recruiting
Study of Volrustomig in Women With High Risk Locally Advanced Cervical Cancer (eVOLVE-Cervical)
NCT06079671Locally Advanced Cervical Cancer
DrugVolrustomig
AstraZeneca
Phase 3
800
Alabama, Arizona, Arkansas, California, Georgia, Illinois, Indiana, Louisiana
2023-09-22
Active, closed
A Study of Investigational Tirzepatide (LY3298176) Doses in Participants With Type 2 Diabetes and Obesity
NCT06037252Type 2 Diabetes, Obesity
DrugTirzepatide
Eli Lilly and Company
Phase 2
414
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana
2023-09-21
Recruiting
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of NXT007 in Persons With Severe or Moderate Hemophilia A
NCT05987449Hemophilia A
Hoffmann-La Roche
Phase 1/2
60
California, District of Columbia, Indiana, Iowa
2023-09-21
Active, closed
Aventus Thrombectomy System Pulmonary Embolism Clinical Study
NCT05907564Pulmonary Embolism, Embolism, Embolism and Thrombosis, Vascular Diseases
Inquis Medical, Inc.
Not applicable
120
Arizona, California, Connecticut, District of Columbia, Georgia, Illinois, Indiana, Louisiana
2023-09-20
Active, closed
A Phase 2a Proof-of-Concept Trial of Bempikibart (ADX-914) for the Treatment of Severe Alopecia Areata (SIGNAL-AA)
NCT06018428Alopecia Areata
DrugBempikibart
Q32 Bio Inc.
Phase 2
75
Arizona, Arkansas, California, Connecticut, Florida, Indiana, Kentucky, Massachusetts
2023-09-12
Recruiting
A Multicenter, Postmarket Surveillance Study of Subjects With the Canary canturioTM te Tibial Extension
NCT06040827Knee Osteoarthritis
Canary Medical
Observational
626
Arkansas, Florida, Georgia, Indiana, Ohio, South Carolina
2023-09-12
Recruiting
IC-8 Apthera IOL New Enrollment Post Approval Study
NCT06060041Cataract, Presbyopia, Posterior Capsule Opacification
Bausch & Lomb Incorporated
Observational
435
Alabama, California, Florida, Illinois, Indiana, Kansas, Michigan, Nebraska
2023-09-08
Active, closed
To Compare the Efficacy and Safety of the ATEV With AVF in Female Patients With End-Stage Renal Disease Requiring Hemodialysis
NCT05908084End Stage Renal Disease (ESRD)
Humacyte, Inc.
Phase 3
121
Arizona, California, Colorado, Connecticut, Florida, Georgia, Indiana, Maryland
2023-09-07
Recruiting
Clinical Data Registry of Amblyopia Patients on Luminopia Treatment
NCT06429280Amblyopia
Luminopia
Observational
500
California, Florida, Georgia, Hawaii, Illinois, Indiana, Nevada, New Hampshire
2023-09-01
Active, closed
Enlighten Study: The EV-ICD Post Approval Registry
NCT06048731Ventricular Arrhythmia, Tachycardia
Medtronic
Observational
1,000
California, Connecticut, Florida, Georgia, Indiana, Iowa, Kentucky, Maryland
2023-09-01
Active, closed
A Study of an Intermittent ADT Approach With Apalutamide Monotherapy in Participants With mCSPC
NCT05884398Metastatic Castrate-sensitive Prostate Cancer
DrugApalutamide
Janssen Research & Development, LLC
Phase 3
420
Alabama, Arizona, Arkansas, California, Colorado, Florida, Illinois, Indiana
2023-08-31
Recruiting
A Study of Olverembatinib in Patients With Newly Diagnosed Ph+ ALL (POLARIS-1)
NCT06051409Ph+ ALL, Leukemia, Lymphoblastic, Acute, Philadelphia-Positive
DrugOlverembatinib
Ascentage Pharma Group Inc.
Phase 3
350
Alabama, California, Florida, Georgia, Indiana, Kentucky, New Jersey, New York
2023-08-31
Recruiting
Multicenter Trial of Antibiotic Eluting Graft for Promoting New Bone Growth in/Near Infected Bone Cavities
NCT05361941Periprosthetic Joint Infections
Elute, Inc.
Not applicable
204
California, District of Columbia, Illinois, Indiana, Maryland, Massachusetts, Michigan, New York
2023-08-31
Active, closed
A Phase 2/3 Trial to Assess the Efficacy and Safety of OCU410ST for Stargardt Disease
NCT05956626Stargardt Disease
Ocugen
Phase 2/3
51
Arizona, California, Florida, Indiana, Massachusetts, Mississippi, Missouri, North Carolina
2023-08-25
Recruiting
A Study To Learn About Two Study Medicines (PF-07275315 And PF-07264660) In People Who Have Moderate To Severe Atopic Dermatitis
NCT05995964Atopic Dermatitis
DrugTilrekimig
Pfizer
Phase 2
340
Alabama, Arizona, California, Colorado, Florida, Indiana, Maryland, Michigan
2023-08-22
Recruiting
A Study to Evaluate the Safety and Efficacy of NEXAGON® (Lufepirsen Ophthalmic Gel) in Subjects With PCED
NCT05966493Persistent Corneal Epithelial Defect
Glaukos Corporation
Phase 2
84
Alabama, California, Colorado, Florida, Georgia, Indiana, Michigan, Missouri
2023-08-17
Recruiting
Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer
NCT05803941Prostate Cancer
DrugLu-PSMA
Novartis Pharmaceuticals
Phase 4
700
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Indiana
2023-08-14
By invitation
Evaluation of Long-Term Safety and Efficacy of Vanzacaftor/Tezacaftor/Deutivacaftor in Cystic Fibrosis Participants 1 Year of Age and Older
NCT05844449Cystic Fibrosis
DrugVNZ/TEZ/D-IVA
Vertex Pharmaceuticals Incorporated
Phase 3
174
California, Colorado, Georgia, Illinois, Indiana, Massachusetts, Minnesota, Missouri
2023-08-11
Active, closed
BCG in Combination With Durvalumab in Adult BCG-naïve, High-risk NMIBC Participants
NCT05943106Non-Muscle- Invasive Bladder Cancer
DrugDurvalumab
AstraZeneca
Phase 3
100
Arizona, Arkansas, California, Colorado, Florida, Indiana, Kansas, Maryland
2023-08-11
Active, closed
The BD Liverty™ TIPS Stent Graft Study
NCT05711316Portal Hypertension, TIPS
C. R. Bard
Not applicable
177
California, District of Columbia, Indiana, Kansas, Massachusetts, Missouri, New Jersey, New York
2023-08-08
Recruiting
A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).
NCT05947851Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Chronic Lymphocytic, Small-Cell Lymphoma, Lymphoma, Small Lymphocytic
DrugsNemtabrutinib·Venetoclax·Rituximab
Merck Sharp & Dohme LLC
Phase 3
735
Arkansas, California, Florida, Indiana, Maryland, Mississippi, Missouri, Montana
2023-08-08
Recruiting
AS-1763 in Patients With Previously Treated CLL/SLL or Non-Hodgkin Lymphoma
NCT05602363B-cell Malignancy, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Waldenstrom Macroglobulinemia
Carna Biosciences, Inc.
Phase 1
120
California, Florida, Illinois, Indiana, Maryland, Massachusetts, New York, North Carolina
2023-08-01
Recruiting
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of RLS-0071 in Newborns With Moderate or Severe Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia
NCT05778188Hypoxic-Ischemic Encephalopathy
DrugRLS-0071
ReAlta Life Sciences, Inc.
Phase 2
70
Arkansas, California, Florida, Indiana, Kentucky, Massachusetts, Missouri, North Carolina
2023-07-27
Recruiting
Clinical Evaluation of BCDx for Monitoring of Recurrence in Non-Muscle Invasive Bladder Cancer
NCT05982561Bladder Cancer
Early is Good Inc.
Observational
500
Arkansas, Indiana, Missouri
2023-07-26
Active, closed
Abbott Ventricular Tachycardia PAS
NCT05839873Ventricular Tachycardia
Abbott Medical Devices
Observational
62
Florida, Indiana, Kansas, Massachusetts, Minnesota, North Carolina, Oklahoma, South Carolina
2023-07-24
Recruiting
Study of Navtemadlin as Maintenance Therapy in TP53WT Advanced or Recurrent Endometrial Cancer
NCT05797831Endometrial Cancer
DrugNavtemadlin
Kartos Therapeutics, Inc.
Phase 2/3
268
California, Georgia, Illinois, Indiana, Maryland, Minnesota, Missouri, Nevada
2023-07-17
Recruiting
Evaluate REC-4881 in Participants With Familial Adenomatous Polyposis (FAP)
NCT05552755Familial Adenomatous Polyposis
Recursion Pharmaceuticals Inc.
Phase 1/2
67
Arizona, California, Florida, Indiana, Louisiana, Michigan, Minnesota, Missouri
2023-07-10
Active, closed
A Study of Zigakibart in Adults With IgA Nephropathy
NCT05852938IgA Nephropathy, Immunoglobulin A Nephropathy
DrugZigakibart
Novartis Pharmaceuticals
Phase 3
383
Alabama, California, Colorado, Florida, Illinois, Indiana, Iowa, Minnesota
2023-07-06
Active, closed
A Study to Evaluate Impact of Efanesoctocog Alfa on Long-term Joint Health in Participants With Hemophilia A
NCT05911763Hemophilia A
DrugEfanesoctocog alfa
Sanofi
Observational
200
Arizona, California, Colorado, Florida, Illinois, Indiana, Iowa, Massachusetts
2023-06-30
Active, closed
Prospective, Multi-Center, Observational, Whole Blood Specimen Collection Study in Participants With Rheumatoid Arthritis With Inadequate Response or Intolerance to a DMARD Starting a New bDMARD or tsDMARD Treatment +/- csDMARD
NCT05936970Rheumatoid Arthritis
Aqtual, Inc.
Observational
1,410
Arizona, California, Florida, Idaho, Illinois, Indiana, Michigan, Minnesota
2023-06-29
Active, closed
ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors
NCT05671510Non Small Cell Lung Cancer
DrugsGotistobart·Taxotere·Docetaxel
OncoC4, Inc.
Phase 3
630
Alabama, Arkansas, California, Connecticut, Florida, Illinois, Indiana, Kansas
2023-06-28
Active, closed
A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)
NCT05878769Chronic Obstructive Pulmonary Disease
DrugAstegolimab
Hoffmann-La Roche
Phase 3
2,000
Alabama, Arizona, California, Florida, Georgia, Illinois, Indiana, Louisiana
2023-06-28
Active, closed
A Study to Evaluate the Safety and Efficacy of CT1812 in Early Alzheimer's Disease
NCT05531656Early Alzheimer's Disease
Cognition Therapeutics
Phase 2
540
Alabama, Arizona, California, Connecticut, District of Columbia, Florida, Illinois, Indiana
2023-06-28
Active, closed
A Study of Efficacy and Safety of Pembrolizumab Plus Enfortumab Vedotin (EV) +/- Investigational Agents in First-Line Metastatic Urothelial Carcinoma (mUC) (MK-3475-04B/KEYMAKER-U04)
NCT05845814Metastatic Urothelial Carcinoma, Urothelial Neoplasms
DrugsPembrolizumab/Vibostolimab·Pembrolizumab/Favezelimab·Keytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 1/2
390
California, Colorado, Georgia, Indiana, Massachusetts, Missouri, New York, North Carolina
2023-06-23
Active, closed
A Study to Assess the Efficacy and Safety of Daily OM-85 in Young Children With Recurrent Wheezing
NCT05857930Recurrent Wheezing, Wheezing Lower Respiratory Illness
DrugBroncho-Vaxom
OM Pharma SA
Phase 2
296
Arizona, Arkansas, California, Colorado, Florida, Illinois, Indiana, Kentucky
2023-06-20
Recruiting
Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab
NCT05877963Relapsing Multiple Sclerosis
DrugUblituximab
TG Therapeutics, Inc.
Phase 3
800
Alabama, California, Colorado, District of Columbia, Florida, Georgia, Illinois, Indiana
2023-06-13
Active, closed
Study of LP-184 in Patients With Advanced Solid Tumors
NCT05933265Advanced Solid Tumor, Metastatic Solid Tumor, GBM, TNBC - Triple-Negative Breast Cancer
DrugsOlaparib·Ipilimumab
Lantern Pharma Inc.
Phase 1/2
64
Arkansas, Indiana, Kentucky, Maryland, Pennsylvania, Texas, Utah
2023-06-09
Active, closed
Evaluation of the Safety and Efficacy of Eneboparatide (AZP-3601) in Patients With Chronic Hypoparathyroidism
NCT05778071Chronic Hypoparathyroidism, Endocrine System Diseases, Parathyroid Diseases
Alexion Pharmaceuticals, Inc.
Phase 3
165
California, Colorado, Illinois, Indiana, Massachusetts, Minnesota, Nevada, New York
2023-06-07
By invitation
Long-term Extension Study to Assess Adverse Events of Oral Atogepant Tablets in Pediatric Participants (6 to 17 Years of Age) With Migraine
NCT05707949Migraine Prophylaxis
DrugAtogepant
AbbVie
Phase 3
650
Alabama, Arkansas, California, Colorado, Florida, Georgia, Indiana, Kansas
2023-06-05
Active, closed
Study to Compare Furmonertinib to Platinum-Based Chemotherapy for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations (FURVENT)
NCT05607550Metastatic Non-Small Cell Lung Cancer, Advanced Non-Small Cell Lung Cancer, EGFR Exon 20 Mutations
DrugFurmonertinib
ArriVent BioPharma, Inc.
Phase 3
398
Alabama, Arizona, Arkansas, California, Connecticut, Florida, Illinois, Indiana
2023-06-01
Active, closed
The Synergy Disc for the Treatment of 2 Level Cervical Degenerative Disc Disease Compared With Cervical Fusion Surgery
NCT05740176Cervical Degenerative Disc Disease
Synergy Spine Solutions
Not applicable
200
Arizona, California, Colorado, Florida, Indiana, Kansas, Louisiana, Michigan
2023-06-01
Active, closed
Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer
NCT05740566Small Cell Lung Cancer (SCLC)
DrugsAmrubicin·Lurbinectedin·Tarlatamab·Topotecan
Amgen
Phase 3
509
Alabama, Alaska, Arkansas, California, Illinois, Indiana, Iowa, Kentucky
2023-05-31
Active, closed
iFuse TORQ for the Treatment of Sacroiliac Joint Dysfunction
NCT05870488Sacroiliac Joint Dysfunction, Sacroiliac; Fusion, Sacroiliac Disorder, Sacroiliac Joint Pain
SI-BONE, Inc.
Phase 4
110
California, Indiana, Kansas, Kentucky, Maryland, Missouri, Nevada, Oklahoma
2023-05-23
Recruiting
A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)
NCT05442567Ulcerative Colitis, Crohn's Disease
DrugVedolizumab
Takeda
Phase 3
240
Alabama, Arizona, California, Florida, Georgia, Illinois, Indiana, Maryland
2023-05-16
Recruiting
Study of Rondecabtagene Autoleucel in Aggressive Large B-Cell Lymphoma
NCT05826535Relapsed Non-Hodgkin Lymphoma, Refractory Non-Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Large B-cell Lymphoma
DrugsRondecabtagene autoleucel·Fludarabine·Cyclophosphamide
Lyell Immunopharma, Inc.
Phase 1/2
270
California, Colorado, District of Columbia, Georgia, Indiana, Iowa, Kentucky, Louisiana
2023-05-09
Recruiting
The Ailliance Post-Market Clinical Study
NCT05856370Spinal Deformity, Spinal Degenerative Disorder, Spinal Fusion Failure, Spinal Trauma
Medtronic Spinal and Biologics
Not applicable
1,000
Arizona, Arkansas, California, Indiana, Kentucky, Maryland, Michigan, Minnesota
2023-05-01
Recruiting
A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine
NCT05711394Episodic Migraine
DrugAtogepant
AbbVie
Phase 3
450
Alabama, Arkansas, California, Colorado, Florida, Georgia, Indiana, Kansas
2023-05-01
By invitation
An Open-label Study of XEN1101 in Epilepsy
NCT05718817Focal Epilepsy, Tonic-Clonic Seizures
DrugAzetukalner
Xenon Pharmaceuticals Inc.
Phase 3
880
Arizona, Arkansas, California, Colorado, Florida, Hawaii, Idaho, Indiana
2023-04-25
Active, closed
Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma
NCT05611931Endometrial Cancer
DrugSelinexor
Karyopharm Therapeutics Inc
Phase 3
257
Alabama, Arizona, Arkansas, California, Florida, Georgia, Illinois, Indiana
2023-04-18
Active, closed
A Study of PARG Inhibitor IDE161 in Participants With Advanced Solid Tumors
NCT05787587Advanced or Metastatic Solid Tumors, Breast Cancer, Ovarian Cancer, Prostate Cancer
DrugsKeytruda·Pembrolizumab
IDEAYA Biosciences
Phase 1
216
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana
2023-04-18
Recruiting
Pounce™ Thrombectomy System Retrospective Registry
NCT05868161Peripheral Arterial Disease, Acute Limb Ischemia
SurModics, Inc.
Observational
500
Illinois, Indiana, Louisiana, Minnesota, Ohio, South Carolina, South Dakota, Tennessee
2023-04-18
Recruiting
Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2
NCT05555589Neurotrophic Keratopathy
ReGenTree, LLC
Phase 3
70
California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana, Kentucky
2023-04-11
Active, closed
Study to Evaluate Adverse Events and Change in Disease Activity in Adult Participants With B-Cell Malignancies Receiving Oral ABBV-525 Tablets
NCT05618028Diffuse Large B-Cell Lymphoma, Chronic Lymphocytic Leukemia, B Cell Malignancies, Non-Hodgkin's Lymphoma
AbbVie
Phase 1
78
California, Connecticut, Florida, Indiana, Louisiana, Michigan, New York, North Carolina
2023-04-04
Recruiting
Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer
NCT05735080Breast Cancer, Breast Cancer Metastatic, Hormone Receptor Positive Tumor, Human Epidermal Growth Factor 2 Negative Carcinoma of Breast
DrugsAbemaciclib·Fulvestrant
Incyclix Bio
Phase 1/2
150
Florida, Georgia, Indiana, Massachusetts, Michigan, New York, North Carolina, Ohio
2023-03-28
Recruiting
A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies
NCT05669430Solid Tumor, Adult, Refractory Cancer, Endometrial Carcinoma (EC), Squamous Head and Neck Carcinoma
DrugsGV20-0251·Keytruda·Pembrolizumab
GV20 Therapeutics
Phase 1/2
365
California, Colorado, Connecticut, Florida, Indiana, Massachusetts, Michigan, New York
2023-03-23
Active, closed
A Study of TAR-200 in Combination With Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants With BCG-naïve High-risk Non-muscle Invasive Bladder Cancer (HR-NMIBC)
NCT05714202Bladder Cancer
DrugsTAR-200·Cetrelimab
Janssen Research & Development, LLC
Phase 3
1,135
Arizona, Arkansas, California, Colorado, Florida, Georgia, Illinois, Indiana
2023-03-23
Recruiting
A Study to Assess Adverse Events of Intravenously (IV) Infused Etentamig (ABBV-383) in Adult Participants With Relapsed or Refractory Multiple Myeloma
NCT05650632Multiple Myeloma
DrugEtentamig
AbbVie
Phase 1
210
Arizona, Arkansas, Colorado, Delaware, Illinois, Indiana, Louisiana, Maryland
2023-03-21
Recruiting
A Post-Authorisation Safety Study (PASS) of Patients Treated With Lonapegsomatropin
NCT05775523Growth Hormone Deficiency
Ascendis Pharma Endocrinology Division A/S
Observational
500
Arizona, California, Colorado, District of Columbia, Florida, Georgia, Idaho, Indiana
2023-03-20
Recruiting
A US Non-interventional, Effectiveness and Safety Study of Patients Treated With SKYTROFA
NCT05820672Growth Hormone Deficiency
Ascendis Pharma Endocrinology Division A/S
Observational
900
Arizona, California, Colorado, District of Columbia, Florida, Georgia, Idaho, Indiana
2023-03-20
Active, closed
Thoraflex Hybrid and Relay Extension Post-Approval Study
NCT05639400Thoracic Diseases, Aortic Aneurysm, Aortic Dissection, Thoracic Aortic Aneurysm
Vascutek Ltd.
Observational
352
Alabama, California, Colorado, Connecticut, District of Columbia, Illinois, Indiana, Maryland
2023-03-17
Active, closed
Study of Novel Treatment Combinations in Patients With Lung Cancer
NCT05633667Lung Cancer, Advanced or Metastatic Non-Small-Cell Lung Cancer, Resectable Non-Small-Cell Lung Cancer
DrugsDomvanalimab·Zimberelimab·Sacituzumab Govitecan·Nab-paclitaxel
Gilead Sciences
Phase 2
192
Arizona, Indiana, Kentucky, Missouri, Ohio, Oregon
2023-03-16
Active, closed
Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer
NCT05445778Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
DrugsMirvetuximab Soravtansine·Bevacizumab
AbbVie
Phase 3
520
Alabama, Arizona, California, Florida, Georgia, Illinois, Indiana, Iowa
2023-03-15
Recruiting
Open Label, Safety and Efficacy Study of QRX003 Lotion in Subjects With Netherton Syndrome
NCT05789056Netherton Syndrome
DrugQRX003, Lotion
Quoin Pharmaceuticals
Phase 2/3
20
California, Indiana, Massachusetts, Texas
2023-03-14
Recruiting
Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein
NCT05677971Alpha1-Antitrypsin Deficiency
DrugFazirsiran
Takeda
Phase 3
160
Alabama, Arizona, California, Colorado, Florida, Georgia, Indiana, Iowa
2023-03-06
Active, closed
Phase 3 Study to Evaluate Two Regimens of Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 1)
NCT05639114Systemic Lupus Erythematosus
DrugIanalumab
Novartis Pharmaceuticals
Phase 3
436
Alabama, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana
2023-03-02
Recruiting
A Study of Baricitinib (LY3009104) in Children From 6 Years to Less Than 18 Years of Age With Alopecia Areata
NCT05723198Areata Alopecia, Alopecia, Hypotrichosis, Hair Diseases
DrugBaricitinib
Eli Lilly and Company
Phase 3
595
Alabama, Arizona, California, Connecticut, Florida, Georgia, Illinois, Indiana
2023-02-27
Active, closed
Study to Assess the Safety and Efficacy of OCU410 for Geographic Atrophy
NCT06018558Geographic Atrophy
Ocugen
Phase 1/2
60
Arizona, Florida, Indiana, Mississippi, Missouri, New Jersey, North Carolina, Pennsylvania
2023-02-23
By invitation
Safety Study of Tenapanor for the Treatment of Pediatric Patients (6 to Less Than 18 Years Old) With IBS-C
NCT05905926Irritable Bowel Syndrome With Constipation (IBS-C)
DrugTenapanor
Ardelyx
Phase 3
150
Alabama, California, Florida, Illinois, Indiana, Maine, Minnesota, Nebraska
2023-02-17
Active, closed
A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77)
NCT05722015Metastatic Non-small Cell Lung Cancer
DrugsPegylated filgrastim·Pembrolizumab Formulated with Berahyaluronidase Alfa·Filgrastim·Taxol
Merck Sharp & Dohme LLC
Phase 3
377
Arizona, Florida, Illinois, Indiana, Kentucky, Mississippi, Missouri
2023-02-14
Active, closed
A Research Study Looking at Long-term Treatment With Mim8 in People With Haemophilia A
NCT05685238Haemophilia A, Haemophilia A With Inhibitors
Novo Nordisk A/S
Phase 3
451
California, Colorado, Florida, Georgia, Illinois, Indiana, Iowa, Michigan
2023-02-13
Active, closed
A Safety and Efficacy Study of PVX108 in Children and Adolescents With Peanut Allergy
NCT05621317Peanut Allergy, Peanut Hypersensitivity, Peanut-Induced Anaphylaxis, Immune System Diseases
Aravax Pty Ltd
Phase 2
90
Arkansas, California, Georgia, Indiana, Maryland, Massachusetts, North Carolina
2023-02-09
Recruiting
A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Adult Participants at Increased Genetic Risk for This Condition
NCT05519475Metabolic Dysfunction-Associated SteatoHepatitis (MASH)
Regeneron Pharmaceuticals
Phase 2
120
Arizona, California, Colorado, Florida, Indiana, Louisiana, Maryland, Mississippi
2023-02-09
Active, closed
A Study to Evaluate Change in Disease Activity of Subcutaneous (SC) Epcoritamab Combined With Intravenous and Oral Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine, and Prednisone (R-CHOP) or R-CHOP in Adult Participants With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)
NCT05578976Diffuse Large B-Cell Lymphoma
DrugsEpcoritamab·Vincristine·Doxorubicin·Prednisone
Genmab
Phase 3
900
Arizona, Arkansas, California, Colorado, Florida, Hawaii, Illinois, Indiana
2023-02-08
Active, closed
Investigating Geographic Atrophy Insights (i-GAIN) Natural History Study
NCT05797896Dry Age-related Macular Degeneration, Geographic Atrophy, Retinal Disease, Macular Degeneration
Complement Therapeutics
Observational
250
California, Indiana, Maryland, Nevada, Oregon, Pennsylvania, Texas
2023-02-07
Active, closed
Study of Ianalumab Versus Placebo in Addition to First-line Corticosteroids in Primary Immune Thrombocytopenia (ITP)
NCT05653349Primary Immune Thrombocytopenia (ITP)
DrugIanalumab
Novartis Pharmaceuticals
Phase 3
226
Arizona, California, Colorado, Florida, Illinois, Indiana, Maryland, Massachusetts
2023-02-03
Active, closed
Open-Label Extension Study of DCCR in Patients With Prader-Willi Syndrome
NCT05701774Prader-Willi Syndrome
Soleno Therapeutics, Inc.
Phase 3
83
California, Florida, Georgia, Indiana, Maryland, Massachusetts, Michigan, Minnesota
2023-01-31
Active, closed
A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Eosinophilic Asthma
NCT05748600Eosinophilic Asthma, Asthma; Eosinophilic, Asthma Attack
DrugDexpramipexole Dihydrochloride
Areteia Therapeutics
Phase 3
600
Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana, Kentucky
2023-01-30
Active, closed
A Study Investigating the Efficacy and Safety of Alcestobart (LBL-007) Plus Tislelizumab in Combination With Bevacizumab Plus Fluoropyrimidine Versus Bevacizumab Plus Fluoropyrimidine in Participants With Unresectable or Metastatic Colorectal Cancer
NCT05609370Unresectable or Metastatic Microsatellite Stable/Mismatch Repair Proficient Colorectal Cancer
DrugsAlcestobart·Fluoropyrimidine·Bevacizumab biosimilar·Tislelizumab
BeiGene
Phase 1/2
113
Alaska, Arizona, California, Florida, Indiana, Kentucky, Louisiana, Missouri
2023-01-29
Active, closed
US Pivotal Clinical Study of the Adient Absorbable Filter for the Prevention of Pulmonary Embolism
NCT05127915Pulmonary Embolism
Adient Medical
Not applicable
854
Colorado, Indiana
2023-01-27
Recruiting
A Study to See if Tolvaptan is Safe in Infants and Children Who at Enrollment Are 28 Days to Less Than 18 Years Old With Autosomal Recessive Polycystic Kidney Disease (ARPKD)
NCT04782258Autosomal Recessive Polycystic Kidney (ARPKD)
DrugTolvaptan
Otsuka Pharmaceutical Development & Commercialization, Inc.
Phase 3
20
District of Columbia, Georgia, Illinois, Indiana, Louisiana, Maryland, Michigan, Minnesota
2023-01-23
Active, closed
Open-Label Extension Study to Evaluate the Long Term Safety and Efficacy of ESK-001 in Plaque Psoriasis
NCT05739435Plaque Psoriasis
DrugEnvudeucitinib
Alumis Inc
Phase 2
165
Alabama, Arizona, Arkansas, California, Florida, Georgia, Illinois, Indiana
2023-01-17
Active, closed
SKB264 in Combination With Pembrolizumab in Subjects With Selected Solid Tumors
NCT05642780Solid Tumor
DrugsSacituzumab tirumotecan·Keytruda·Pembrolizumab
Klus Pharma Inc.
Phase 2
240
Indiana, Kentucky, Maryland, Minnesota, New York, Texas, Virginia
2023-01-17
Recruiting
FORAGER-1: A Study of Vepugratinib (LY3866288; LOXO-435) in Participants With Cancer With a Change in a Gene Called FGFR3
NCT05614739Urinary Bladder Neoplasms, Neoplasm Metastasis, Ureteral Neoplasms
DrugsVepugratinib·Digoxin·Enfortumab Vedotin·Rosuvastatin
Eli Lilly and Company
Phase 1
677
Arizona, California, Florida, Georgia, Illinois, Indiana, Louisiana, Maryland
2023-01-12
Active, closed
A Study to Evaluate the Long-Term Effect of TEV-48574 in Moderate to Severe Ulcerative Colitis or Crohn's Disease
NCT05668013Crohn Disease, Colitis, Ulcerative
DrugDuvakitug
Teva Branded Pharmaceutical Products R&D LLC
Phase 2
247
California, Florida, Illinois, Indiana, Kansas, Kentucky, Missouri, Nevada
2023-01-11
Active, closed
Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve
NCT05526560Mitral Stenosis, Mitral Valve Insufficiency
Edwards Lifesciences
Observational
504
California, Florida, Georgia, Indiana, Michigan, Minnesota, Missouri, New York
2023-01-11
Recruiting
Alleviant ALLAY-HF Study
NCT05685303Heart Failure
Alleviant Medical, Inc.
Not applicable
700
Arizona, California, Connecticut, Florida, Georgia, Illinois, Indiana, Kentucky
2023-01-10
Recruiting
DEFIANCE: RCT of ClotTriever System Versus Anticoagulation In Deep Vein Thrombosis
NCT05701917Venous Thromboembolism, Deep Venous Thrombosis, Post-Thrombotic Syndrome
Inari Medical
Not applicable
300
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Indiana
2023-01-06
Active, closed
Efficacy and Safety of Encaleret Compared to Standard of Care in Participants With ADH1
NCT05680818Autosomal Dominant Hypocalcemia (ADH)
DrugEncaleret
Calcilytix Therapeutics, Inc., a BridgeBio company
Phase 3
67
California, Colorado, Indiana, Maryland, Massachusetts, Minnesota, New York, North Carolina
2023-01-06
Active, closed
Phase 2b Study of GSK4532990 in Adults With NASH
NCT05583344Nonalcoholic Fatty Liver Disease, Non-alcoholic Fatty Liver Disease
DrugGSK4532990
GlaxoSmithKline
Phase 2
284
Alabama, Arizona, Arkansas, California, Colorado, Florida, Georgia, Indiana
2023-01-02
Active, closed
Phase III, Open-label, First-line Study of Dato-DXd in Combination With Durvalumab and Carboplatin for Advanced NSCLC Without Actionable Genomic Alterations
NCT05687266NSCLC
DrugsDato-DXd·Durvalumab·Pemetrexed·Paclitaxel
AstraZeneca
Phase 3
1,350
Arizona, Arkansas, California, Colorado, Florida, Illinois, Indiana, Iowa
2022-12-29
Active, closed
A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease
NCT05595642Chronic Obstructive Pulmonary Disease (COPD)
DrugAstegolimab
Hoffmann-La Roche
Phase 3
1,290
Alabama, Arizona, California, Florida, Georgia, Indiana, Kentucky, Louisiana
2022-12-29
Recruiting
Safety and Effectiveness of Giroctocogene Fitelparvovec or Fidanacogene Elaparvovec in Patients With Hemophilia A or B Respectively
NCT05568719Hemophilia A, Hemophilia B
Pfizer
Phase 3
173
California, Florida, Indiana, Mississippi, New York, Pennsylvania, Washington
2022-12-28
Active, closed
Safety and Effectiveness of the Genio® bilAteral Stimulation for Treatment of Complete Concentric CollapsE and OSA.
NCT05592002Sleep Apnea, Obstructive
Nyxoah S.A.
Not applicable
124
Colorado, Florida, Indiana, Iowa, Kansas, Massachusetts, New York, Pennsylvania
2022-12-28
Active, closed
ONC-392 and Pembrolizumab in Platinum Resistant Ovarian Cancer
NCT05446298Ovarian Cancer, High Grade Serous Adenocarcinoma of Ovary, Primary Peritoneal Carcinoma, Fallopian Tube Cancer
DrugsGotistobart·Keytruda·Pembrolizumab
OncoC4, Inc.
Phase 2
58
Arizona, Connecticut, Florida, Illinois, Indiana, Kentucky, Louisiana, Minnesota
2022-12-22
Active, closed
CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)
NCT05681351Severe Hypertriglyceridemia
DrugOlezarsen
Ionis Pharmaceuticals, Inc.
Phase 3
885
California, Florida, Georgia, Illinois, Indiana, Kansas, Kentucky, Louisiana
2022-12-13
Recruiting
Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease
NCT05650229Primary Mitochondrial Disease
DrugNapazimone
Pharming Technologies B.V.
Phase 2
180
California, Colorado, Connecticut, Florida, Georgia, Indiana, Maryland, Minnesota
2022-12-13
Active, closed
(HALT) Embrace Hydrogel Embolic System (HES) Study of Embolization in Peripheral Arterial Bleeds
NCT05364502Arterial Bleeding in Solid Organs and Peripheral Arteries
Instylla, Inc.
Not applicable
130
Arizona, California, Connecticut, District of Columbia, Florida, Illinois, Indiana, Maryland
2022-12-12
Active, closed
Study to Evaluate Adverse Events, Change in Disease Activity, and How ABBV-706 Moves Through the Body When Intravenously (IV) Infused Alone or in Combination With IV Infused Budigalimab, Cisplatin, or Carboplatin in Adult Participants With Advanced Solid Tumors
NCT05599984Advanced Solid Tumors
DrugsABBV-706·Budigalimab·Cisplatin·Carboplatin
AbbVie
Phase 1
288
Arizona, California, Connecticut, District of Columbia, Illinois, Indiana, Iowa, Michigan
2022-12-05
By invitation
An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)
NCT05667493Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)
DrugEplontersen
Ionis Pharmaceuticals, Inc.
Phase 3
1,400
Arizona, California, Colorado, District of Columbia, Florida, Georgia, Illinois, Indiana
2022-11-30
Active, closed
A Study to Learn About The COVID-19 (Study) Vaccine (Called COMIRNATY) in People That Are Less Than 21 Years Old.
NCT05295290Myocarditis
Pfizer
Phase 4
319
California, Connecticut, District of Columbia, Florida, Georgia, Indiana, Louisiana, Massachusetts
2022-11-21
Active, closed
To Evaluate Efficacy and Safety of Serplulimab + Chemotherapy (Carboplatin- Etoposide) in US Patients With ES-SCLC
NCT05468489Extensive Stage Small Cell Lung Cancer
DrugsSerplulimab·Atezolizumab
Shanghai Henlius Biotech
Phase 3
200
Alabama, Arizona, Arkansas, California, Colorado, Florida, Illinois, Indiana
2022-11-18
Recruiting
A Substudy of Investigational Agents in Programmed Cell Death-1/Ligand 1 (PD-1/L1) Refractory Locally Advanced or Metastatic Urothelial Carcinoma (mUC) (MK-3475-04A)
NCT05562830Urothelial Carcinoma
DrugsMK-3120·Zilovertamab vedotin·Keytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 1/2
48
California, Colorado, Illinois, Indiana, Missouri, New York, Ohio, Pennsylvania
2022-11-16
Active, closed
Embody Post-Market Clinical Follow-Up Study
NCT05735119Tendon Injuries- Subscapularis
Zimmer Biomet
Observational
100
California, Florida, Indiana, Kentucky
2022-11-09
Active, closed
A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight
NCT05567796Obesity
DrugsCagrilintide·Semaglutide
Novo Nordisk A/S
Phase 3
3,400
Alabama, California, Colorado, Florida, Georgia, Hawaii, Illinois, Indiana
2022-11-01
Active, closed
A Study to Assess Efficacy, Safety, and Tolerability of P1101 in Adult Patients With PV
NCT05481151Polycythemia Vera
DrugBesremi
PharmaEssentia
Phase 3
111
Florida, Indiana, Kansas, Kentucky, Louisiana, Maryland, Missouri, New Jersey
2022-10-26
Active, closed
A Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Participants With Pulmonary Arterial Hypertension
NCT05203510Pulmonary Arterial Hypertension
DrugTreprostinil
United Therapeutics
Phase 4
52
Arizona, California, Connecticut, Florida, Georgia, Illinois, Indiana, Massachusetts
2022-10-20
Active, closed
Evaluating Safety and Efficacy of ADX-914 in Patients With Moderate to Severe Atopic Dermatitis (SIGNAL-AD)
NCT05509023Atopic Dermatitis
DrugBempikibart
Q32 Bio Inc.
Phase 2
102
Alabama, California, Florida, Georgia, Idaho, Illinois, Indiana, Maryland
2022-09-30
Active, closed
A Single-arm, Multicenter Study to Assess the Efficacy, Safety, and Tolerability of P1101 in Adults With ET
NCT05482971Essential Thrombocythemia
DrugBesremi
PharmaEssentia
Phase 2
91
Alabama, California, Connecticut, District of Columbia, Georgia, Indiana, Kentucky, Louisiana
2022-09-29
Active, closed
Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Follicular Lymphoma
NCT05409066Follicular Lymphoma (FL)
DrugsEpcoritamab·Lenalidomide·Rituximab
Genmab
Phase 3
549
Arizona, Arkansas, California, Georgia, Hawaii, Illinois, Indiana, Louisiana
2022-09-20
Active, closed
CAMPFIRE: A Study of Abemaciclib (LY2835219) in Participants With Ewing's Sarcoma
NCT05440786Sarcoma, Ewing, Neoplasm Metastasis
DrugsAbemaciclib·Temozolomide·Irinotecan
Eli Lilly and Company
Phase 2
46
Arizona, California, Indiana, Missouri, Rhode Island
2022-09-20
Active, closed
A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis
NCT05242484Colitis, Ulcerative
DrugsJNJ-78934804·Golimumab·Guselkumab
Janssen Research & Development, LLC
Phase 2
577
California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Idaho, Indiana
2022-09-19
Active, closed
The Willow LTE Study With M5049 in Participants With SCLE, DLE and/or SLE (WILLOW LTE)
NCT05540327Systemic Lupus Erythematosus
DrugEnpatoran
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Phase 2
379
California, Florida, Indiana, Michigan, Minnesota, Ohio, Tennessee
2022-09-16
Active, closed
A Phase III Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Non Small Cell Lung Cancer (NSCLC) Whose Disease Progressed On or After Prior Anti PD (L)1 Therapy And Platinum Based Chemotherapy
NCT05450692Advanced or Metastatic Non-Small Cell Lung Cancer
DrugsCeralasertib·Durvalumab·Docetaxel
AstraZeneca
Phase 3
594
Alabama, Arizona, California, Florida, Georgia, Indiana, Maryland, Mississippi
2022-09-15
Active, closed
A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus
NCT05531565Subacute Cutaneous Lupus Erythematosus, Chronic Cutaneous Lupus Erythematosus
DrugLitifilimab
Biogen
Phase 2/3
450
Alabama, Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana
2022-09-13
Active, closed
Study of XL092 + Atezolizumab vs Regorafenib in Participants With Metastatic Colorectal Cancer
NCT05425940Colorectal Cancer
DrugsZanzalintinib·Regorafenib·Tecentriq·Atezolizumab
Exelixis
Phase 3
901
Alabama, Arizona, California, Connecticut, Florida, Georgia, Illinois, Indiana
2022-09-07
By invitation
Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease
NCT04905693Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease, Progressive Pulmonary Fibrosis
DrugTreprostinil
United Therapeutics
Phase 3
1,850
Alabama, Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana
2022-09-06
Recruiting
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
NCT05489211Endometrial Cancer, Gastric Cancer, Metastatic Castration-resistant Prostate Cancer, Ovarian Cancer
DrugsPrednisone/Prednisolone·Volrustomig·Rilvegostomig·Dato-DXd
AstraZeneca
Phase 2
454
California, Indiana, Kansas, Massachusetts, Michigan, New Jersey, New Mexico, New York
2022-09-06
Active, closed
Safety, Tolerability, Pharmacodynamic, Efficacy, and Pharmacokinetic Study of DYNE-101 in Participants With Myotonic Dystrophy Type 1
NCT05481879Myotonic Dystrophy Type 1 (DM1)
DrugZeleciment basivarsen
Dyne Therapeutics
Phase 1/2
127
California, Florida, Indiana, Iowa, Missouri, New York, Texas, Virginia
2022-09-05
Active, closed
Study of Sonrotoclax (BGB-11417) Monotherapy in Participants With Relapsed or Refractory Mantle Cell Lymphoma
NCT05471843Mantle Cell Lymphoma, Refractory Mantle Cell Lymphoma (MCL), Relapsed Mantle Cell Lymphoma
DrugSonrotoclax
BeOne Medicines
Phase 1/2
125
Alabama, Indiana, Louisiana, Maryland, New Jersey, Texas
2022-09-05
Recruiting
Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)
NCT05281471Platinum-resistant Ovarian Cancer, Platinum-refractory Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
DrugsOlvimulogene nanivacirepvec·Pegylated liposomal doxorubicin·Nab-paclitaxel·Bevacizumab
Genelux Corporation
Phase 3
186
Alabama, Arizona, California, Florida, Georgia, Indiana, Maryland, Michigan
2022-08-31
Active, closed
Safety, Tolerability and PK of Subcutaneous D-4517.2 in Subjects With Wet AMD or DME
NCT05387837Neovascular Age-related Macular Degeneration, Diabetic Macular Edema
DrugAflibercept
Ashvattha Therapeutics, Inc.
Phase 2
50
California, Illinois, Indiana, Maryland, Massachusetts, Missouri, New Jersey, Pennsylvania
2022-08-31
Recruiting
A Study Evaluating the Safety and Efficacy of HB0036 in Subjects With Advanced Solid Tumors
NCT05417321Advanced Solid Tumor, NSCLC
Shanghai Huaota Biopharmaceutical Co., Ltd.
Phase 1/2
80
Indiana, Texas, Washington
2022-08-25
Active, closed
Moderate - Severe Degenerative Disc Disease Evaluation of the Lumbar Spine
NCT05516992Lumbar Degenerative Disc Disease
Spine BioPharma, Inc
Phase 3
417
Alabama, Arizona, California, Florida, Georgia, Idaho, Indiana, Kansas
2022-08-19
Recruiting
A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Participants With Multiple Myeloma That is Resistant to Current Standard of Care Treatments
NCT05137054Multiple Myeloma
DrugsNirogacestat·Cevostamab·Fianlimab·Linvoseltamab
Regeneron Pharmaceuticals
Phase 1
317
California, Georgia, Indiana, Massachusetts, Michigan, Minnesota, New York, North Carolina
2022-08-17
Active, closed
GammaTile and Stupp in Newly Diagnosed GBM
NCT05342883Glioblastoma
GT Medical Technologies, Inc.
Phase 4
61
Arizona, California, Florida, Georgia, Illinois, Indiana, Kansas, Michigan
2022-08-17
Active, closed
MiSight 1 Day Safety Post-Approval Study
NCT05285527Myopia
CooperVision, Inc.
Not applicable
2,400
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Illinois, Indiana
2022-08-15
Active, closed
A Study of Ivaltinostat Plus Capecitabine or Capecitabine in Metastatic Pancreatic Adenocarcinoma
NCT05249101Metastatic Pancreatic Adenocarcinoma
DrugsXeloda·Capecitabine
CG Pharmaceuticals, Inc
Phase 1/2
70
Arizona, California, Georgia, Indiana, Kentucky, Louisiana, Michigan, New York
2022-08-15
Recruiting
CorMatrix Cor TRICUSPID ECM Valve Replacement - Pivotal Study
NCT05742906Tricuspid Valve Disease, Tricuspid Valve Insufficiency
Corvivo Cardiovascular, Inc.
Not applicable
92
Indiana, New York
2022-08-10
Active, closed
A Phase 1/2 Study of BA3071 in Patients With Solid Tumors
NCT05180799NSCLC, Melanoma
DrugsPemetrexed·Nivolumab·Pembrolizumab
BioAtla, Inc.
Phase 1/2
320
California, Georgia, Indiana, New Jersey, New York, Ohio, Oregon, Utah
2022-08-03
Active, closed
Evaluation of Rifaximin SSD for Delaying Encephalopathy Decompensation in Patients With Cirrhosis
NCT05297448Hepatic Encephalopathy
DrugRifaximin SSD
Bausch Health Americas, Inc.
Phase 3
466
Alabama, Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana
2022-08-03
Active, closed
A Study of Tirzepatide Compared With Intensified Conventional Care in Adult Participants With Type 2 Diabetes
NCT05433584Type 2 Diabetes
DrugTirzepatide
Eli Lilly and Company
Phase 4
780
Alabama, California, Connecticut, Florida, Georgia, Indiana, Iowa, Kentucky
2022-08-01
Recruiting
CorMatrix Cor TRICUSPID ECM Valve Replacement Study
NCT02397668Tricuspid Valve Disease
Corvivo Cardiovascular, Inc.
Not applicable
78
Alabama, Indiana, Maryland, Ohio
2022-08-01
Active, closed
LYT-100 in Patients With Idiopathic Pulmonary Fibrosis (IPF)
NCT05321420Idiopathic Pulmonary Fibrosis
DrugsDeupirfenidone·Pirfenidone
PureTech
Phase 2
240
Alabama, California, Connecticut, Florida, Georgia, Indiana, Kansas, North Carolina
2022-07-22
By invitation
ORACLE: A Long-term Follow-up Study to Evaluate the Safety of GT005 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration Treated in a Gyroscope-sponsored Antecedent Study
NCT05481827Age Related Macular Degeneration (AMD)
Gyroscope Therapeutics Limited
Phase 2
225
California, Colorado, Florida, Illinois, Indiana, Iowa, Maryland, Massachusetts
2022-07-12
Recruiting
Deep Neural Network Stratification for Use Detecting Endometriosis in Women Affected by Chronic Pelvic Pain (EndoCheck)
NCT05245695Endometriosis
Aspira Women's Health
Observational
1,200
Arizona, California, Delaware, Georgia, Indiana, Maryland, New York, Ohio
2022-07-12
Active, closed
Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events
NCT05360446Coronary Artery Disease
DrugInclisiran sodium
Novartis Pharmaceuticals
Phase 3
610
Alabama, Alaska, California, Connecticut, District of Columbia, Florida, Illinois, Indiana
2022-07-08
Recruiting
Patient Specific Talus Spacer Post Approval Study
NCT05364606Avascular Necrosis of the Talus
Paragon 28
Observational
50
California, Indiana, Maryland, South Carolina, Texas
2022-07-08
Active, closed
Roll-over Study to Allow Continued Access to Ribociclib
NCT05161195Metastatic Breast Cancer
DrugsGoserelin·Tamoxifen·Anastrozole·Ribociclib
Novartis Pharmaceuticals
Phase 4
134
Arizona, Arkansas, California, Colorado, Florida, Georgia, Illinois, Indiana
2022-07-07
Active, closed
A Study to Evaluate the Efficacy and Safety of Taldefgrobep Alfa in Participants With Spinal Muscular Atrophy
NCT05337553Spinal Muscular Atrophy, Neuromuscular Diseases, SMA
DrugTaldefgrobep alfa
Biohaven Pharmaceuticals, Inc.
Phase 3
269
Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana, Iowa
2022-07-06
Active, closed
An Open-label Extension Study to Evaluate Long-term Efficacy and Safety of Odevixibat in Children With Biliary Atresia
NCT05426733Biliary Atresia
DrugOdevixibat
Albireo, an Ipsen Company
Phase 3
180
Colorado, Georgia, Indiana, Massachusetts, Missouri, New York, Ohio, Washington
2022-07-05
Active, closed
Endoscopic Evidence of Maintenance of Healing With Oral NEXIUM in Patients 1 to 11 Years Old With Erosive Esophagitis.
NCT05267613Erosive Esophagitis
DrugNexium
AstraZeneca
Phase 3
53
Alabama, California, Florida, Indiana, Louisiana, New York, Ohio, Wisconsin
2022-07-01
Recruiting
An Observational Study of Carbaglu® for the Treatment of MMA and PA in Adults and Pediatrics
NCT05040178Hyperammonemia, Methylmalonic Acidemia, Propionic Acidemia
DrugCarglumic Acid
RECORDATI GROUP
Observational
20
District of Columbia, Florida, Illinois, Indiana, New York
2022-06-30
Active, closed
Relacorilant in Combination With Nab-Paclitaxel in Advanced, Platinum-Resistant, High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian-Tube Cancer
NCT05257408Ovarian Neoplasm, Fallopian Tube Neoplasms, Peritoneal Neoplasms
DrugsNab-paclitaxel /m^2·Relacorilant
Corcept Therapeutics
Phase 3
381
Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana, Kansas
2022-06-29
Active, closed
MiSight 1 Day Post-Approval Study for Effectiveness and Visual Symptoms
NCT05285553Myopia
CooperVision, Inc.
Not applicable
900
Alabama, California, Florida, Illinois, Indiana, Kansas, Massachusetts, Minnesota
2022-06-25
Active, closed
Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
NCT04975997Multiple Myeloma
DrugsIberdomide·Bortezomib·Daratumumab·Dexamethasone
Celgene
Phase 3
939
Arkansas, California, Connecticut, Florida, Georgia, Illinois, Indiana, Kentucky
2022-06-23
Active, closed
Safety, Tolerability and Efficacy of QRX003 Lotion in Subjects With Netherton Syndrome
NCT05521438Netherton Syndrome
DrugQRX003, Lotion
Quoin Pharmaceuticals
Phase 2/3
30
California, Indiana, Massachusetts, South Carolina, Texas
2022-06-23
Active, closed
Evaluation of VX-121/Tezacaftor/Deutivacaftor in Cystic Fibrosis (CF) Participants 1 Through 11 Years of Age
NCT05422222Cystic Fibrosis
DrugVNZ/TEZ/D-IVA
Vertex Pharmaceuticals Incorporated
Phase 3
210
California, Colorado, Georgia, Illinois, Indiana, Massachusetts, Minnesota, Missouri
2022-06-21
Recruiting
A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)
NCT05462106Amyloid Plaque, Beta-Amyloid, DSAD, Prodromal Alzheimer's Disease
AC Immune SA
Phase 1/2
304
Arizona, Florida, Indiana, Kansas, Massachusetts, Missouri, North Carolina, Tennessee
2022-06-21
Recruiting
ALLIANCE: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve
NCT05172960Aortic Stenosis, Severe
Edwards Lifesciences
Not applicable
1,234
California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana, Kansas
2022-06-20
Active, closed
Study to Evaluate the Safety and Efficacy of Pegvaliase in Adolescents (Ages 12-17) With Phenylketonuria
NCT05270837Phenylketonuria (PKU)
DrugPegvaliase
BioMarin Pharmaceutical
Phase 3
55
Arizona, Arkansas, Colorado, Florida, Illinois, Indiana, Kentucky, Massachusetts
2022-06-17
Active, closed
Non-interventional Study on Osilodrostat in Patients With Endogenous Cushing's Syndrome
NCT05382156Endogenous Cushing's Syndrome
DrugOsilodrostat
RECORDATI GROUP
Observational
206
Arizona, Georgia, Illinois, Indiana, Kentucky, Massachusetts, Michigan, Minnesota
2022-06-13
Recruiting
A Long-term, Post-marketing Safety Study of Palynziq in Patients With PKU (PALace)
NCT05813678Phenylketonuria (PKU)
DrugPegvaliase
BioMarin Pharmaceutical
Observational
450
Colorado, Georgia, Illinois, Indiana, Louisiana, Massachusetts, Oregon, Pennsylvania
2022-06-06
Recruiting
Study of ORIC-944 in Patients With Metastatic Prostate Cancer
NCT05413421Metastatic Prostate Cancer
DrugsDarolutamide (Nubeqa)·Rinzimetostat·Apalutamide (Erleada)
ORIC Pharmaceuticals
Phase 1
275
Colorado, Florida, Illinois, Indiana, Maryland, Michigan, Minnesota, New York
2022-06-01
Recruiting
A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Moderate to Severe Active Ulcerative Colitis
NCT05076175Colitis, Ulcerative
DrugOzanimod
Bristol-Myers Squibb
Phase 2/3
120
Arizona, California, Connecticut, District of Columbia, Florida, Georgia, Illinois, Indiana
2022-05-30
Active, closed
An Observational Study of the Progression of Intermediate Age-Related Macular Degeneration
NCT05300724Age-Related Macular Degeneration
Genentech, Inc.
Observational
400
Arkansas, California, Colorado, Florida, Georgia, Illinois, Indiana, Iowa
2022-05-27
Recruiting
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants
NCT05039619Lupus Nephritis
DrugsAcetaminophen/paracetamol·Diphenhydramine hydrochloride·Mycophenolate Mofetil·Methylprednisolone
Hoffmann-La Roche
Phase 2
40
California, Colorado, Georgia, Indiana, Louisiana, New Jersey, New York, Ohio
2022-05-12
Active, closed
The AUDACITY Study (AllUrion Device in Adults With Clinical ObesITY)
NCT05368259Obesity
Allurion Technologies
Not applicable
1,000
Arizona, California, Colorado, Florida, Illinois, Indiana, Massachusetts, Missouri
2022-05-12
Active, closed
RADIANCE Continued Access Protocol
NCT05017935Hypertension, Hypertension, Resistant to Conventional Therapy, Vascular Diseases, Cardiovascular Diseases
ReCor Medical, Inc.
Not applicable
300
California, Connecticut, Florida, Georgia, Illinois, Indiana, Iowa, Louisiana
2022-05-04
Recruiting
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
NCT05366881Brain Cancer, Breast Cancer, Bladder Cancer, Cervical Cancer
Adela, Inc
Observational
7,000
California, Florida, Georgia, Indiana, Kentucky, Minnesota, Ohio, Oregon
2022-05-03
Active, closed
A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis
NCT05269004Multiple Sclerosis
DrugOcrelizumab
Hoffmann-La Roche
Phase 3
1,300
Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana, Kansas
2022-05-03
Active, closed
A Study of Abemaciclib (LY2835219) With Abiraterone in Men With Prostate Cancer That Has Spread to Other Parts of the Body and is Expected to Respond to Hormonal Treatment (Metastatic Hormone-Sensitive Prostate Cancer)
NCT05288166Prostatic Neoplasms, Neoplasm Metastasis, Urogenital Neoplasms, Physiological Effects of Drugs
DrugsAbiraterone·Abemaciclib·Prednisolone·Prednisone
Eli Lilly and Company
Phase 3
925
Arizona, Arkansas, California, Colorado, Florida, Georgia, Indiana, Kentucky
2022-04-14
Active, closed
Study of Erdafitinib Intravesical Delivery System for Localized Bladder Cancer
NCT05316155Non-Muscle Invasive Bladder Neoplasms
DrugErdafitinib
Janssen Research & Development, LLC
Phase 1/2
235
Alabama, California, Colorado, Florida, Illinois, Indiana, Kentucky, Louisiana
2022-04-11
Active, closed
A Phase 3 Study of Rusfertide in Patients With Polycythemia Vera
NCT05210790Polycythemia Vera
DrugRusfertide
Protagonist Therapeutics, Inc.
Phase 3
293
Alabama, Arizona, California, Colorado, Connecticut, Florida, Illinois, Indiana
2022-04-01
Recruiting
A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
NCT04928846Non Small Cell Lung Cancer, c-MET
DrugsTelisotuzumab vedotin·Docetaxel
AbbVie
Phase 3
768
Alabama, Arizona, California, Florida, Georgia, Hawaii, Illinois, Indiana
2022-03-25
Active, closed
Remote Optimization, Adjustment and Measurement for Deep Brain Stimulation
NCT05269862Parkinson Disease
Abbott Medical Devices
Not applicable
100
Arizona, California, Florida, Illinois, Indiana, Massachusetts, New Hampshire, Ohio
2022-03-24
Active, closed
A Research Study on How Well Concizumab Works for You if You Have Haemophilia A or B With or Without Inhibitors
NCT05135559Haemophilia A and B With and Without Inhibitors
DrugConcizumab
Novo Nordisk A/S
Phase 3
153
California, Colorado, Florida, Georgia, Illinois, Indiana, Louisiana, Missouri
2022-03-24
Active, closed
Pembrolizumab/Vibostolimab (MK-7684A) or Atezolizumab in Combination With Chemotherapy in First Line Treatment of Extensive-Stage Small Cell Lung Cancer (MK-7684A-008/KEYVIBE-008)
NCT05224141Small Cell Lung Carcinoma
DrugsPembrolizumab/Vibostolimab·Tecentriq·Paraplatin·Etoposide
Merck Sharp & Dohme LLC
Phase 3
460
Alabama, California, Florida, Indiana, Massachusetts, Michigan, Mississippi, Pennsylvania
2022-03-24
Active, closed
A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)
NCT05239728Carcinoma, Renal Cell
DrugsBelzutifan·Keytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
1,800
Arizona, California, Colorado, District of Columbia, Florida, Georgia, Indiana, Maryland
2022-03-15
Active, closed
A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma
NCT05100862Relapsed/Refractory Follicular Lymphoma, Marginal Zone Lymphoma
DrugsRuxience·Truxima·Zanubrutinib·Obinutuzumab
BeOne Medicines
Phase 3
799
California, Florida, Georgia, Illinois, Indiana, Iowa, Kansas, Kentucky
2022-03-10
Recruiting
A Long-term Study for Participants Previously Treated With Ciltacabtagene Autoleucel
NCT05201781Multiple Myeloma
DrugCilta-cel
Janssen Research & Development, LLC
Phase 4
295
Arizona, California, Florida, Georgia, Illinois, Indiana, Kansas, Massachusetts
2022-03-09
Active, closed
A Masked, Placebo-controlled Study to Assess Iptacopan in Age-related Macular Degeneration
NCT05230537Age-Related Macular Degeneration
DrugIptacopan
Novartis Pharmaceuticals
Phase 2
168
California, Colorado, Florida, Indiana, Louisiana, Maryland, Massachusetts, New Jersey
2022-02-17
Recruiting
Efficacy and Safety of Subcutaneous Dupilumab for the Treatment of Adult Participants With Chronic Pruritus of Unknown Origin (CPUO) (LIBERTY-CPUO-CHIC)
NCT05263206Pruritus
DrugsFexofenadine·Dupilumab
Sanofi
Phase 3
284
California, District of Columbia, Florida, Georgia, Indiana, Kentucky, Louisiana, Maryland
2022-02-15
Active, closed
A Study of a Patient-Specific Neoantigen Vaccine in Combination With Immune Checkpoint Blockade for Patients With Metastatic Colorectal Cancer
NCT05141721Colorectal Neoplasms
DrugsFluoropyrimidine·Yervoy·Tecentriq·Avastin
Seattle Project Corporation
Phase 2/3
700
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Illinois, Indiana
2022-02-12
Active, closed
A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With Sickle Cell Disease (RISE UP)
NCT05031780Sickle Cell Disease
DrugMitapivat
Agios Pharmaceuticals, Inc.
Phase 2/3
286
California, Connecticut, District of Columbia, Florida, Illinois, Indiana, Louisiana, Maryland
2022-02-11
Recruiting
A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn's Disease (CD)
NCT04779320Crohn's Disease (CD)
DrugVedolizumab
Takeda
Phase 3
120
Arizona, California, Florida, Georgia, Illinois, Indiana, Maryland, Massachusetts
2022-02-10
Active, closed
Long-term Assessment of the Safety and Performance of the NuVasive Simplify Disc
NCT05258435Cervical Disc Disease, Degenerative Disc Disease
NuVasive
Observational
131
California, Colorado, Florida, Illinois, Indiana, Louisiana, North Carolina, Texas
2022-02-09
Active, closed
A Global Study to Assess the Effects of Durvalumab With Oleclumab or Durvalumab With Monalizumab Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer
NCT05221840Non-Small Cell Lung Cancer
DrugsMonalizumab·Oleclumab·Durvalumab
AstraZeneca
Phase 3
1,051
California, Connecticut, Florida, Illinois, Indiana, Kentucky, Maryland, Michigan
2022-02-07
Recruiting
A Study to Evaluate the Safety and Tolerability of ALN-APP in Patients With EOAD
NCT05231785Early-Onset Alzheimer Disease
DrugsAln-App·Mivelsiran
Alnylam Pharmaceuticals
Phase 1
60
California, Indiana
2022-02-04
Recruiting
Assessment of CCM in HF With Higher Ejection Fraction
NCT05064709Heart Failure, Heart Failure With Preserved Ejection Fraction, Heart Failure With Mid Range Ejection Fraction, Heart Failure With Moderately Reduced Ejection Fraction
Impulse Dynamics
Not applicable
1,500
Alabama, Arizona, California, Connecticut, Florida, Georgia, Indiana, Iowa
2022-02-03
Active, closed
Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma (MK-3475-C93/KEYNOTE-C93/GOG-3064/ENGOT-en15)
NCT05173987Endometrial Neoplasms
DrugsTaxotere·Paraplatin·Taxol·Docetaxel
Merck Sharp & Dohme LLC
Phase 3
280
Arizona, California, Connecticut, Florida, Georgia, Illinois, Indiana, Kentucky
2022-02-03
Active, closed
First in Human Study of TORL-2-307-ADC in Participants With Advanced Cancer
NCT05156866Advanced Solid Tumor, Gastric Cancer, Pancreas Cancer, Gastroesophageal Junction Adenocarcinoma
TORL Biotherapeutics, LLC
Phase 1
163
California, Indiana, Missouri, Texas
2022-02-02
Active, closed
Post Approval Study2: Hintermann Series H3 Total Ankle Replacement System
NCT04770870Osteoarthritis Ankle, Post-Traumatic Osteoarthritis of Ankle, Osteoarthritis of Ankle Secondary to Inflammatory Arthritis (Disorder)
DT MedTech, LLC
Not applicable
94
Arkansas, California, Florida, Indiana, Maryland, New Mexico, North Carolina, Oklahoma
2022-02-01
Active, closed
A Study of Anvumetostat in Participants With Advanced MTAP-null Solid Tumors (MTAPESTRY 101)
NCT05094336Advanced MTAP-null Solid Tumors
DrugsAnvumetostat·Docetaxel
Amgen
Phase 1/2
329
California, Florida, Indiana, Maryland, Michigan, Missouri, New Jersey, New York
2022-02-01
Active, closed
Tumor-induced Osteomalacia Disease Monitoring Program
NCT04783428Tumor-induced Osteomalacia (TIO)
Ultragenyx Pharmaceutical Inc
Observational
23
Connecticut, Indiana, Maryland, Tennessee, Virginia
2022-01-31
Active, closed
ADH1 and ADH2 Disease Monitoring Study (DMS)
NCT05227287Autosomal Dominant Hypocalcemia
Calcilytix Therapeutics, Inc., a BridgeBio company
Observational
95
California, Colorado, Florida, Indiana, Massachusetts, Minnesota, North Carolina, Ohio
2022-01-20
Active, closed
First in Human Study of TORL-2-307-MAB in Participants With Advanced Cancer
NCT05159440Advanced Solid Tumor, Gastric Cancer, Pancreas Cancer, Gastroesophageal Junction Adenocarcinoma
TORL Biotherapeutics, LLC
Phase 1
70
California, Indiana, Missouri
2022-01-20
Recruiting
Pelvic Health Electrically Evoked Recording (PEER) 2 Study
NCT05200923Overactive Bladder, Fecal Incontinence, Urinary Retention
MedtronicNeuro
Not applicable
300
Indiana, Louisiana, Minnesota, Ohio, Texas
2022-01-18
Active, closed
A Study to Assess the Long-Term Safety and Efficacy of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Patients With Hereditary Transthyretin-Mediated Amyloid Polyneuropathy
NCT05071300Hereditary Transthyretin-Mediated Amyloid Polyneuropathy
DrugEplontersen
Ionis Pharmaceuticals, Inc.
Phase 3
151
Arizona, Indiana, Maryland, Massachusetts, New York, North Carolina, Oregon, Washington
2022-01-04
Active, closed
A Study of an Epstein-Barr Virus (EBV) Candidate Vaccine, mRNA-1189, in 10- to 30-Year-Old Healthy Adolescents and Adults
NCT05164094Epstein-Barr Virus Infection
DrugMRNA-1189
ModernaTX, Inc.
Phase 1/2
867
Alabama, California, Florida, Georgia, Idaho, Illinois, Indiana, Iowa
2021-12-28
Active, closed
A Study to Assess Disease Activity and Safety of Subcutaneous Lutikizumab (ABT-981) in Adult Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-Tumor Necrosis Factor (TNF) Therapy and Who Are Naïve to Biologic Therapy
NCT05139602Hidradenitis Suppurativa
DrugLutikizumab
AbbVie
Phase 2
210
Arizona, Arkansas, California, Connecticut, Florida, Indiana, Massachusetts, Michigan
2021-12-28
Recruiting
Study to Determine the Dose and Safety of Asciminib in Pediatric Patients With Chronic Myeloid Leukemia
NCT04925479Myeloid Leukemia, Philadelphia Positive
DrugABL001
Novartis Pharmaceuticals
Phase 1/2
34
Indiana, Massachusetts, Mississippi, New York, Ohio, Pennsylvania, Texas, Utah
2021-12-27
Recruiting
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
NCT05176483Renal Cell Carcinoma (RCC), Metastatic Castration-Resistant Prostate Cancer (mCRPC), Urothelial Carcinoma (UC), Solid Tumor
DrugsZanzalintinib·Relatlimab·Yervoy·Ipilimumab
Exelixis
Phase 1
1,394
Arizona, California, Colorado, Connecticut, Delaware, Florida, Illinois, Indiana
2021-12-14
Active, closed
Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS) (REMODEL-2)
NCT05156281Relapsing Multiple Sclerosis
DrugsTeriflunomide·Remibrutinib
Novartis Pharmaceuticals
Phase 3
1,007
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Indiana, Kansas
2021-12-13
Active, closed
Pembrolizumab/Placebo Plus Paclitaxel With or Without Bevacizumab for Platinum-resistant Recurrent Ovarian Cancer (MK-3475-B96/KEYNOTE-B96/ENGOT-ov65).
NCT05116189Ovarian Cancer, Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms
DrugsZirabev·Taxotere·Avastin·Docetaxel
Merck Sharp & Dohme LLC
Phase 3
643
Arizona, California, Connecticut, Florida, Georgia, Illinois, Indiana, Kentucky
2021-12-13
Recruiting
4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration
NCT05197270Neovascular (Wet) Age-Related Macular Degeneration
DrugsAflibercept IVT·4D-150 IVT
4D Molecular Therapeutics
Phase 1/2
215
Arizona, California, Colorado, Florida, Illinois, Indiana, Maryland, Massachusetts
2021-12-09
Recruiting
First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer
NCT05216432PIK3CA Mutation, Solid Tumor, Adult, HER2-negative Breast Cancer, Breast Cancer
DrugsRLY-2608·Atirmociclib·Ribociclib·Palbociclib
Relay Therapeutics, Inc.
Phase 1
930
Arizona, California, Colorado, Connecticut, Florida, Illinois, Indiana, Massachusetts
2021-12-08
Active, closed
NP-G2-044 as Monotherapy and Combination Therapy in Patients With Advanced or Metastatic Solid Tumor Malignancies
NCT05023486Advanced or Metastatic Solid Tumor Malignancies
DrugPrilukae
Novita Pharmaceuticals, Inc.
Phase 1/2
121
Arizona, Arkansas, California, Connecticut, Florida, Indiana, Kansas, Michigan
2021-12-07
Active, closed
Tapinarof for the Treatment of Plaque Psoriasis in Pediatric Subjects
NCT05172726Plaque Psoriasis
DrugTapinarof
Organon and Co
Phase 3
58
Arkansas, California, Florida, Illinois, Indiana, Ohio, Oregon, Washington
2021-12-02
Active, closed
MRD Assay Evaluates Recurrence and Response Via a Tumor Informed Assessment
NCT05219734Cancer, Solid Tumor, Non Small Cell Lung Cancer, Colorectal Cancer
Invitae Corporation
Observational
400
Indiana, North Carolina
2021-11-29
Active, closed
Safety, Tolerability, and Immunogenicity of MenABCWY Administered on Different Dosing Schedules in Healthy Adolescents
NCT05087056Meningitis, Meningococcal
GlaxoSmithKline
Phase 2
305
Alabama, Arizona, California, District of Columbia, Florida, Georgia, Indiana, Kentucky
2021-11-18
Active, closed
A Phase 3 Study to Evaluate the Safety and Efficacy of Efgartigimod PH20 Subcutaneous in Adult Patients With Primary Immune Thrombocytopenia
NCT04812925Primary Immune Thrombocytopenia
DrugEfgartigimod PH20
argenx
Phase 3
173
Arkansas, District of Columbia, Indiana, Iowa, Oklahoma
2021-11-17
Active, closed
Desara ® One Single Incision Sling 522 Study
NCT04772131Stress Urinary Incontinence
Caldera Medical, Inc.
Not applicable
300
Arizona, Florida, Idaho, Indiana, Kentucky, Massachusetts, Missouri, Nevada
2021-11-01
Recruiting
Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan
NCT05005403Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma, Micro Satellite Stable Colorectal Cancer, Gastric/Esophageal Cancer
DrugsBudigalimab·Telisotuzumab Adizutecan·Bevacizumab
AbbVie
Phase 1
694
California, Illinois, Indiana, Kentucky, Michigan, Minnesota, Nebraska, North Carolina
2021-11-01
Active, closed
A Study Evaluating the Efficacy and Safety of Mosunetuzumab in Combination With Lenalidomide in Comparison to Rituximab in Combination With Lenalidomide With a US Extension of Mosunetuzumab in Combination With Lenalidomide in Participants With Follicular Lymphoma
NCT04712097Relapsed or Refractory Follicular Lymphoma
DrugsMosunetuzumab·Lenalidomide·Rituximab
Hoffmann-La Roche
Phase 3
478
California, Georgia, Indiana, Maryland, Michigan, Missouri, New York, North Carolina
2021-10-27
Active, closed
Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors
NCT04337177Solid Tumors, Neuroblastoma, Rhabdomyosarcoma, Ewing Sarcoma
DrugsTemodal·Temodar·Temozolomide
Valent Technologies, LLC
Phase 1
20
Arizona, California, District of Columbia, Georgia, Indiana, Missouri, North Carolina, Ohio
2021-10-25
Active, closed
Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer
NCT05113251Breast Neoplasms, Breast Cancer, HER2-positive Early Breast Cancer
DrugsHerzuma·Perjeta·Herceptin·Adriamycin
AstraZeneca
Phase 3
927
Arkansas, California, Connecticut, Indiana, Kentucky, Louisiana, Minnesota, Nevada
2021-10-25
By invitation
Long-term Safety Extension Study of OLZ/SAM in Pediatric Subjects
NCT04987229Bipolar I Disorder, Schizophrenia
DrugOLZ/SAM
Alkermes, Inc.
Phase 3
236
Alabama, Arkansas, California, District of Columbia, Florida, Georgia, Illinois, Indiana
2021-10-22
Recruiting
Hepatic Impairment With Cirrhosis Due to Cholestatic Liver Disease
NCT05045482Hepatic Impairment, Cirrhosis, Cholestatic Liver Disease
DrugSaroglitazar Magnesium
Zydus Therapeutics Inc.
Phase 1
30
Indiana
2021-10-21
Active, closed
Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Advanced Solid Tumors Receiving Intravenous (IV) ABBV-400 as Monotherapy and in Combination With IV Bevacizumab
NCT05029882Non-Small Cell Lung Cancer, Advanced Solid Tumors, Gastroesophageal Adenocarcinoma, Colorectal Cancer
DrugsTelisotuzumab Adizutecan·Trifluridine/Tipiracil·Bevacizumab
AbbVie
Phase 1
520
California, Colorado, Connecticut, Illinois, Indiana, Louisiana, Michigan, New York
2021-10-13
Active, closed
Study Evaluating the Safety and Efficacy of Islatravir in Combination With Lenacapavir in Virologically Suppressed People With HIV
NCT05052996HIV-1 Infection
DrugsB/F/TAF·Lenacapavir
Gilead Sciences
Phase 2
142
California, Colorado, District of Columbia, Florida, Georgia, Hawaii, Illinois, Indiana
2021-10-05
Active, closed
A Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer
NCT04975308Breast Neoplasms, Neoplasm Metastasis
DrugsImlunestrant·Exemestane·Abemaciclib·Fulvestrant
Eli Lilly and Company
Phase 3
874
Arizona, California, Colorado, Florida, Hawaii, Illinois, Indiana, Kentucky
2021-10-04
Recruiting
PSMA-PET to Guide Prostatectomy
NCT05381103Prostate Cancer
Five Eleven Pharma, Inc.
Phase 2/3
288
Indiana
2021-10-01
Active, closed
BOLT-DVT: Study of the Indigo® Aspiration System When Used in Patients With Deep Vein Thrombosis
NCT05003843Deep Vein Thrombosis, DVT
Penumbra Inc.
Not applicable
229
California, Delaware, District of Columbia, Florida, Illinois, Indiana, Kentucky, Louisiana
2021-09-30
Active, closed
A Study to Assess the Safety and Efficacy of AZD7789 in Participants With Advanced or Metastatic Solid Cancer
NCT04931654Carcinoma, Non-Small-Cell Lung, Gastric Cancer, Gastroesophageal Junction Cancer
DrugSabestomig
AstraZeneca
Phase 1/2
136
Georgia, Indiana, New York, Tennessee
2021-09-28
Active, closed
A Phase 1/2/3 Study of UX701 Gene Therapy in Adults With Wilson Disease
NCT04884815Wilson Disease
Ultragenyx Pharmaceutical Inc
Phase 1/2
82
California, Illinois, Indiana, Massachusetts, Michigan, North Carolina, Ohio, Tennessee
2021-09-27
Active, closed
A Study of Talquetamab With Other Anticancer Therapies in Participants With Multiple Myeloma
NCT05050097Multiple Myeloma
DrugsTalquetamab·Carfilzomib·Pomalidomide·Daratumumab
Janssen Research & Development, LLC
Phase 1
166
Alabama, California, Colorado, Georgia, Indiana, New Jersey, New York, North Carolina
2021-09-22
Recruiting
Helix Research Network
NCT06057181Genetic Predisposition to Disease, Genetics Disease
Helix, Inc
Observational
2,000,000
Indiana, Minnesota, Nebraska, Nevada, New York, North Carolina, Ohio, Pennsylvania
2021-09-13
Active, closed
Long-term Safety and Efficacy of Odevixibat in Patients With Alagille Syndrome
NCT05035030Alagille Syndrome
DrugOdevixibat
Albireo, an Ipsen Company
Phase 3
62
California, Georgia, Indiana, Maryland, Massachusetts, Missouri, New York, North Carolina
2021-09-03
Active, closed
Safety and Efficacy Study of Investigational Agents as Monotherapy or in Combination With Pembrolizumab (MK-3475) for the Treatment of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) in Need of Second-Line Therapy (MK-3475-B98/KEYNOTE-B98)
NCT04938817Small Cell Lung Carcinoma
DrugsMK-4830·Pembrolizumab/Favezelimab·Pembrolizumab/Quavonlimab·R-DXd
Merck Sharp & Dohme LLC
Phase 1/2
110
Arizona, Georgia, Indiana, Kentucky, Maryland, Nebraska, Ohio, Pennsylvania
2021-08-19
Active, closed
Study Assessing Long-teRm Outcomes of dupiluMAb (DUPIXENT®) Treatment in Adult Patients With Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP)
NCT04959448Chronic Rhinosinusitis With Nasal Polyposis
DrugDupilumab
Regeneron Pharmaceuticals
Observational
717
Alabama, Arizona, California, Florida, Georgia, Idaho, Illinois, Indiana
2021-08-12
Active, closed
Study Comparing Investigational Drug HBI-8000 + Nivolumab vs. Placebo + Nivolumab in Patients With Advanced Melanoma
NCT04674683Unresectable or Metastatic Melanoma, Progressive Brain Metastasis
DrugsChidamide·Nivolumab
HUYABIO International, LLC.
Phase 3
450
California, Florida, Indiana, Kentucky, Maryland, Missouri, Montana, North Carolina
2021-08-12
By invitation
IT Matters: The Erectile Restoration Registry
NCT04200937Erectile Dysfunction
Boston Scientific Corporation
Observational
450
California, Florida, Illinois, Indiana, Louisiana, Missouri, North Carolina, Ohio
2021-08-05
Active, closed
Study of Pembrolizumab (MK-3475) Subcutaneous (SC) Versus Pembrolizumab Intravenous (IV) Administered With Platinum Doublet Chemotherapy in Participants With Metastatic Squamous or Nonsquamous Non-Small Cell Lung Cancer (NSCLC) (MK-3475-A86)
NCT04956692Non-Small Cell Lung Cancer
DrugsAbraxane·Paraplatin·Taxol·Nab-paclitaxel
Merck Sharp & Dohme LLC
Phase 3
531
Arkansas, California, Florida, Indiana, Kentucky, Missouri, Montana, New York
2021-08-05
Active, closed
Treatment Combination of Durvalumab, Tremelimumab and Enfortumab Vedotin or Durvalumab and Enfortumab Vedotin in Patients With Muscle Invasive Bladder Cancer Ineligible to Cisplatin or Who Refuse Cisplatin
NCT04960709Muscle Invasive Bladder Cancer
DrugsEnfortumab Vedotin·Tremelimumab·Durvalumab
AstraZeneca
Phase 3
712
California, Connecticut, District of Columbia, Florida, Idaho, Illinois, Indiana, Iowa
2021-08-05
Active, closed
Ultrasound-facilitated, Catheter-directed, Thrombolysis in Intermediate-high Risk Pulmonary Embolism
NCT04790370Pulmonary Embolism
DrugsLMWH·Heparin
Boston Scientific Corporation
Phase 4
544
Alabama, California, Delaware, Georgia, Indiana, Kentucky, Maryland, Massachusetts
2021-08-02
Not yet open
Measuring the Impact of Onco4D® Guidance on Chemotherapy Selection and Outcomes
NCT04891952Cancer, Chemotherapy Effect
Animated Dynamics, Inc.
Observational
1,000
Indiana
2021-08-01
Recruiting
Study of Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy.
NCT04817618C3G
DrugIptacopan
Novartis Pharmaceuticals
Phase 3
98
Colorado, Florida, Georgia, Indiana, Iowa, Maryland, Massachusetts, New Jersey
2021-07-28
Active, closed
ALTUS: Performance of a Multi- Target Hepatocellular Carcinoma (HCC) Test in Subjects With Increased Risk
NCT05064553Hepatocellular Carcinoma, Hepatocellular Cancer, Hepatitis B, Cirrhosis
Exact Sciences Corporation
Observational
2,990
Arizona, California, Colorado, District of Columbia, Florida, Illinois, Indiana, Iowa
2021-07-26
Active, closed
Study of LY3537982 in Cancer Patients With a Specific Genetic Mutation (KRAS G12C)
NCT04956640Carcinoma, Non-Small-Cell Lung, Colorectal Neoplasms, Endometrial Neoplasms, Ovarian Neoplasms
DrugsOlomorasib·Erbitux·Cetuximab·Pemetrexed
Eli Lilly and Company
Phase 1/2
540
Alabama, California, Connecticut, Florida, Indiana, Louisiana, Massachusetts, New Hampshire
2021-07-19
Active, closed
G7 Acetabular System With Vivacit-E or Longevity Liner PMCF Study
NCT04754087Total Hip Arthroplasty, Degenerative Joint Disease of Hip, Avascular Necrosis of Hip, Rheumatoid Arthritis of Hip
Zimmer Biomet
Not applicable
300
Colorado, Indiana, North Carolina, Oregon, Utah
2021-07-07
Active, closed
Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6)
NCT04964934ER-Positive HER2-Negative Breast Cancer
DrugsCamizestrant·Anastrozole·Abemaciclib·Ribociclib
AstraZeneca
Phase 3
315
Arizona, Arkansas, California, Colorado, Florida, Georgia, Illinois, Indiana
2021-06-30
Recruiting
CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting
NCT05002543Cardiac Valve Disease
Corcym S.r.l
Observational
2,150
Indiana, Louisiana, Maine, North Carolina, Ohio, Pennsylvania
2021-06-29
Recruiting
Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors
NCT04900818Solid Tumor, Advanced Cancer, Metastatic Cancer, Gastric Cancer
DrugGivastomig
I-Mab Biopharma US Limited
Phase 1
330
California, Colorado, Indiana, Massachusetts, New Jersey, New York, North Carolina, Tennessee
2021-06-29
Active, closed
Global Safety and Efficacy Registration Study of Crinecerfont in Pediatric Participants With Classic Congenital Adrenal Hyperplasia (CAHtalyst Pediatric Study)
NCT04806451Congenital Adrenal Hyperplasia
DrugCrinecerfont
Neurocrine Biosciences
Phase 3
103
Alabama, California, Colorado, Connecticut, District of Columbia, Georgia, Indiana, Massachusetts
2021-06-25
Active, closed
Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)
NCT04895358Breast Neoplasms
DrugsLiposomal doxorubicin·Abraxane·Xeloda·Taxol
Merck Sharp & Dohme LLC
Phase 3
342
Alabama, Arizona, California, District of Columbia, Florida, Georgia, Illinois, Indiana
2021-06-18
Recruiting
DPX-Survivac and Pembrolizumab With and Without Intermittent Low-Dose Cyclophosphamide, in Subjects With Relapsed/Refractory Diffuse Large B-Cell Lymphoma
NCT04920617Relapsed Diffuse Large B-cell Lymphoma, Refractory Diffuse Large B-cell Lymphoma
DrugsDPX-Survivac·Procytox·Cytoxan·Keytruda
ImmunoVaccine Technologies, Inc. (IMV Inc.)
Phase 2
102
California, Florida, Georgia, Indiana, Louisiana, Nebraska, New Mexico, North Carolina
2021-06-18
Recruiting
Persona Revision Knee System Outcomes
NCT04821154Arthroplasty Complications, Infection, Knee Disease, Knee Osteoarthritis
Zimmer Biomet
Observational
380
Arkansas, California, Colorado, Indiana, Kentucky, Michigan, Minnesota, Missouri
2021-06-14
Recruiting
A Safety and Dose-finding Study of PRL-02 Depot in Men With Advanced Prostate Cancer
NCT04729114Prostate Cancer, Metastatic Castration Resistant Prostate Cancer, Metastatic Castration-sensitive Prostate Cancer
DrugsPRL-02·Enzalutamide·Prednisone·Dexamethasone
Astellas Pharma Global Development, Inc.
Phase 1
174
Arizona, California, Florida, Indiana, Kansas, Maryland, Nebraska, New Jersey
2021-06-14
Active, closed
Assessing Outcomes With Microprocessor Knee Utilization in a K2 Population
NCT04784429Lower Limb Amputation Above Knee (Injury), Congenital Amputation of Lower Limb, Lower Limb Amputation Knee
Otto Bock Healthcare Products GmbH
Not applicable
107
Alabama, Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana
2021-06-11
Recruiting
Device Global Registry for the IlluminOss Bone Stabilization System
NCT05206981Traumatic Fracture, Pathological Fracture
IlluminOss Medical, Inc.
Observational
300
Alabama, California, Colorado, Florida, Indiana, New York, North Carolina, Pennsylvania
2021-06-11
Recruiting
A Phase 1/2 Study of Bleximenib in Participants With Acute Leukemia (cAMeLot-1)
NCT04811560Acute Leukemia
DrugBleximenib
Janssen Research & Development, LLC
Phase 1/2
420
California, Illinois, Indiana, Kentucky, Massachusetts, Michigan, New Mexico, New York
2021-05-19
Recruiting
Corneal Crosslinking for Treatment of Corneal Neovascularization
NCT04787471Corneal Neovascularization
Price Vision Group
Phase 2/3
138
Indiana
2021-05-03
Active, closed
ARX517/JNJ-95298177 as Monotherapy or Combination Therapy in Subjects With Metastatic Prostate Cancer
NCT04662580Metastatic Prostate Cancer
DrugsARX517·Apalutamide·Abiraterone acetate·Prednisone
Janssen Research & Development, LLC
Phase 1
183
California, Georgia, Indiana, Michigan, Missouri, Nebraska, New York, Ohio
2021-05-03
Recruiting
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
NCT04777357Depression, Bipolar I Disorder
DrugCariprazine
AbbVie
Phase 3
380
Arkansas, California, Florida, Georgia, Illinois, Indiana, Louisiana, Maryland
2021-04-28
Recruiting
The KinematX Midcarpal Total Wrist Arthroplasty Registry
NCT05719935Scapholunate Advanced Collapse (SLAC), Scapholunate Crystalline Advanced Collapse (SCAC), Scaphoid, Trapezium, and Trapezoid Advanced Collapse (STTAC), Carpal Tunnel Syndrome (CTS)
Extremity Medical
Observational
50
California, Florida, Indiana, New York
2021-04-26
Active, closed
Perioperative Enfortumab Vedotin (EV) Plus Pembrolizumab (MK-3475) Versus Neoadjuvant Chemotherapy for Cisplatin-Eligible Muscle Invasive Bladder Cancer (MIBC) (MK-3475-B15/ KEYNOTE-B15 / EV-304)
NCT04700124Bladder Cancer
DrugsEnfortumab Vedotin·Keytruda·Gemcitabine·Cisplatin
Merck Sharp & Dohme LLC
Phase 3
808
Arizona, California, Colorado, Florida, Indiana, Iowa, Kentucky, New York
2021-04-21
Active, closed
Study of IDE397 in Participants With Solid Tumors Harboring MTAP Deletion
NCT04794699Solid Tumor
DrugsIDE397·Sacituzumab Govitecan
IDEAYA Biosciences
Phase 1
169
Arizona, Arkansas, California, Florida, Indiana, Maryland, Massachusetts, New York
2021-04-14
Active, closed
A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)
NCT04736706Carcinoma, Renal Cell
DrugsPembrolizumab/Quavonlimab·Belzutifan·Lenvatinib·Keytruda
Merck Sharp & Dohme LLC
Phase 3
1,688
Alabama, California, Connecticut, Florida, Georgia, Illinois, Indiana, Kentucky
2021-04-14
Active, closed
TRISCEND II Pivotal Trial
NCT04482062Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases
Edwards Lifesciences
Not applicable
864
Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana, Kansas
2021-04-09
Active, closed
Phase 3 Study of Pelabresib (CPI-0610) in Myelofibrosis (MF) (MANIFEST-2)
NCT04603495Myelofibrosis, Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis
DrugsPelabresib·Ruxolitinib
Novartis Pharmaceuticals
Phase 3
430
Alabama, Arizona, California, Connecticut, Florida, Illinois, Indiana, Kentucky
2021-04-09
Active, closed
Post-Surgical Stereotactic Radiotherapy (SRT) Versus GammaTile-ROADS (Radiation One and Done Study)
NCT04365374Brain Metastases
GT Medical Technologies, Inc.
Phase 3
230
Arizona, Arkansas, Florida, Georgia, Illinois, Indiana, Kansas, Kentucky
2021-04-06
Active, closed
SMall Annuli Randomized To Evolut™ or SAPIEN™ Trial
NCT04722250Symptomatic Aortic Stenosis, Aortic Valve Stenosis, Aortic Valve Replacement
Medtronic Cardiovascular
Not applicable
1,103
California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois, Indiana
2021-04-02
Active, closed
Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)
NCT04586023Relapsing Multiple Sclerosis
DrugsFenebrutinib·Teriflunomide
Hoffmann-La Roche
Phase 3
751
Alabama, Arizona, California, District of Columbia, Florida, Indiana, Kansas, Massachusetts
2021-03-24
Active, closed
A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)
NCT04586010Relapsing Multiple Sclerosis
DrugsFenebrutinib·Teriflunomide
Hoffmann-La Roche
Phase 3
746
Alabama, Arizona, California, Colorado, Florida, Illinois, Indiana, Louisiana
2021-03-17
Recruiting
Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System
NCT04555161Pulmonary Arterial Hypertension, Pulmonary Hypertension, Right Heart Dysfunction
Aria CV, Inc
Not applicable
30
California, Indiana, Massachusetts, Minnesota, New York, Ohio, South Carolina, Wisconsin
2021-03-15
Active, closed
Safety and Efficacy Study of reSept ASD Occluder for Treating Secundum ASD
NCT04591392Heart Septal Defect, Heart Septal Defects, Atrial, Heart Defects, Congenital, Cardiovascular Abnormalities
atHeart Medical
Not applicable
250
Alabama, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana
2021-03-12
Active, closed
A Study of Teclistamab With Other Anticancer Therapies in Participants With Multiple Myeloma
NCT04722146Multiple Myeloma
DrugsNirogacestat·Teclistamab·Pomalidomide·Bortezomib
Janssen Research & Development, LLC
Phase 1
140
Alabama, California, Colorado, Georgia, Indiana, Missouri, New Jersey, New York
2021-03-12
Active, closed
A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer
NCT04486378Colorectal Cancer Stage II, Colorectal Cancer Stage III
DrugAutogene cevumeran
BioNTech SE
Phase 2
327
California, Indiana, Minnesota, Ohio, Rhode Island, Tennessee, Texas, Virginia
2021-03-08
Recruiting
A Study of Axatilimab at 3 Different Doses in Participants With Chronic Graft Versus Host Disease (cGVHD)
NCT04710576Chronic Graft-versus-host-disease
DrugAxatilimab
Syndax Pharmaceuticals
Phase 2
296
Alabama, California, District of Columbia, Florida, Georgia, Illinois, Indiana, Louisiana
2021-03-04
Active, closed
A Clinical Trial Comparing the BAGUERA C to the Marketed Mobi-C® for the Treatment of Cervical Disc Disease at 2 Contiguous Levels
NCT04564885Cervical Disc Disease
Spineart USA
Not applicable
300
Arizona, California, Colorado, Connecticut, District of Columbia, Georgia, Illinois, Indiana
2021-03-02
Active, closed
A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)
NCT04586231Carcinoma, Renal Cell
DrugsBelzutifan·Cabozantinib·Lenvatinib
Merck Sharp & Dohme LLC
Phase 3
747
Arizona, California, District of Columbia, Florida, Georgia, Illinois, Indiana, Kentucky
2021-02-25
Active, closed
Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
NCT04685135Metastatic Non Small Cell Lung Cancer, Advanced Non Small Cell Lung Cancer
DrugsAdagrasib·Taxotere·Docetaxel
Mirati Therapeutics Inc.
Phase 3
453
California, Colorado, Florida, Georgia, Illinois, Indiana, Kansas, Kentucky
2021-02-23
Recruiting
Safety and Efficacy of KRT-232 in Combination With Acalabrutinib in Subjects With R/R DLBCL or R/R CLL
NCT04502394Diffuse Large B Cell Lymphoma, Chronic Lymphocytic Leukemia, Non Hodgkin Lymphoma
DrugsNavtemadlin·Acalabrutinib
Kartos Therapeutics, Inc.
Phase 1/2
84
Indiana, Ohio, Texas
2021-02-23
Recruiting
PANTHER Study of Terumo Aortic Knitted and Woven Grafts, and Cardiovascular Patches
NCT04545502Aneurysm, Dissection, Aortic Root Aneurysm, Aortic Root Dissection
Vascutek Ltd.
Observational
2,000
Colorado, Florida, Indiana, North Carolina, Ohio, Pennsylvania, Virginia
2021-02-17
Active, closed
Firehawk Rapamycin Target Eluting Coronary Stent North American Trial
NCT04562532Coronary Artery Disease
Shanghai MicroPort Medical (Group) Co., Ltd.
Not applicable
1,720
Alabama, Arizona, California, Connecticut, Florida, Georgia, Indiana, Kansas
2021-02-17
Active, closed
Immunogenicity, Safety, Reactogenicity and Persistence of an Investigational Respiratory Syncytial Virus (RSV) Vaccine in Adults Aged 60 Years and Above
NCT04732871Respiratory Syncytial Virus Infections
GlaxoSmithKline
Phase 3
1,720
Alabama, Arizona, California, Florida, Indiana, Kansas, Minnesota, Missouri
2021-02-15
By invitation
Sepsis Clinical Decision Support [CDS] Master Enrollment Study Protocol
NCT05304728Severe Sepsis, Severe Sepsis Without Septic Shock
Beckman Coulter, Inc.
Observational
40,000
California, Georgia, Indiana, Missouri, New Jersey, North Carolina, Ohio
2021-02-15
Active, closed
Paresthesia-Free Fast-Acting Subperception (FAST) Study
NCT04618471Chronic Pain
Boston Scientific Corporation
Not applicable
177
California, Colorado, Florida, Illinois, Indiana, Louisiana, New York, North Carolina
2021-02-10
Active, closed
Pharmacokinetics, Safety, and Efficacy of ASTX727 in Combination With Venetoclax in Acute Myeloid Leukemia (AML)
NCT04657081Acute Myeloid Leukemia
DrugsDecitabine·Venclexta·Venetoclax
Taiho Oncology, Inc.
Phase 1/2
101
California, Connecticut, Florida, Illinois, Indiana, Massachusetts, Missouri, New Jersey
2021-02-09
Active, closed
A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease
NCT04711252ER-Positive HER2-Negative Breast Cancer
DrugsCamizestrant·Anastrozole·Palbociclib
AstraZeneca
Phase 3
1,371
Alabama, Arkansas, California, Colorado, Florida, Indiana, Louisiana, Maryland
2021-01-28
Recruiting
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
NCT04657068Advanced Cancer, Metastatic Cancer, Ovarian Cancer, Primary Peritoneal Cancer
DrugsIrinotecan·Gemcitabine
Artios Pharma Ltd
Phase 1/2
542
Alabama, Arizona, Arkansas, California, Colorado, Florida, Illinois, Indiana
2021-01-27
Active, closed
Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study
NCT04589845Solid Tumors
DrugsCamonsertib·Belvarafenib·Pralsetinib·Divarasib
Hoffmann-La Roche
Phase 2
920
Arizona, California, Georgia, Idaho, Illinois, Indiana, Maryland, Michigan
2021-01-18
Active, closed
A Phase 3 Trial of Epcoritamab vs Investigator's Choice Chemotherapy in Relapsed/Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL)
NCT04628494Diffuse Large B-cell Lymphoma
DrugEpcoritamab
Genmab
Phase 3
483
Indiana, Kentucky, Michigan, Minnesota, New Jersey, North Carolina, Ohio, Texas
2021-01-13
Active, closed
A Long-term Study of Nemolizumab (CD14152) in Participants With Prurigo Nodularis (PN)
NCT04204616Prurigo Nodularis
DrugNemolizumab
Galderma R&D
Phase 3
500
Alabama, California, District of Columbia, Florida, Georgia, Illinois, Indiana, Kansas
2021-01-11
Active, closed
A Study of T-DXd for the Treatment of Solid Tumors Harboring HER2 Activating Mutations
NCT04639219Advanced Solid Tumors With HER2 Mutation,eg:Colorectal,Urothelial,Gastric, Hepatobiliary,Endometrial,Melanoma,Ovarian,Cervical,Salivary Gland,Pancreatic,Breast
DrugTrastuzumab deruxtecan
AstraZeneca
Phase 2
102
California, Indiana, Massachusetts, New Jersey, New York, Texas, Virginia
2020-12-30
Recruiting
Secukinumab Open Label Roll-over Extension Protocol
NCT04638647Autoimmunity, Inflammation
DrugSecukinumab
Novartis Pharmaceuticals
Phase 4
1,000
California, Colorado, Florida, Illinois, Indiana, Maryland, Michigan, Nebraska
2020-12-22
Active, closed
Study of DS-1062a Versus Docetaxel in Previously Treated Advanced or Metastatic Non-small Cell Lung Cancer With or Without Actionable Genomic Alterations (TROPION-LUNG01)
NCT04656652Non-small Cell Lung Cancer
DrugsDato-DXd·Docetaxel
Daiichi Sankyo
Phase 3
605
Arizona, California, Florida, Illinois, Indiana, Kentucky, Louisiana, Maryland
2020-12-21
Active, closed
Nodify XL2 Classifier Clinical Utility Study in Low to Moderate Risk Lung Nodules
NCT04171492Nodule Solitary Pulmonary, Non-small Cell Carcinoma
Biodesix, Inc.
Observational
2,000
Colorado, Connecticut, District of Columbia, Indiana, Maryland, Michigan, Minnesota, Missouri
2020-12-18
Active, closed
A Study of TAR-200 in Combination With Cetrelimab, TAR-200 Alone, or Cetrelimab Alone in Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Intravesical Bacillus Calmette-Guérin Who Are Ineligible for or Elected Not to Undergo Radical Cystectomy
NCT04640623Urinary Bladder Neoplasms
DrugsTAR-200·Cetrelimab
Janssen Research & Development, LLC
Phase 2
220
Arizona, California, Colorado, Illinois, Indiana, Kansas, Michigan, New York
2020-12-18
Recruiting
Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having HFpEF
NCT04592445Heart Failure With Preserved Ejection Fraction (HFpEF
Axon Therapies, Inc.
Not applicable
150
Alabama, Arizona, California, Georgia, Illinois, Indiana, Louisiana, Michigan
2020-12-18
Active, closed
Global Safety and Efficacy Registration Study of Crinecerfont for Congenital Adrenal Hyperplasia
NCT04490915Congenital Adrenal Hyperplasia
DrugCrinecerfont
Neurocrine Biosciences
Phase 3
182
California, Colorado, Georgia, Indiana, Maryland, Massachusetts, Michigan, Minnesota
2020-12-16
Active, closed
Atrasentan in Patients With IgA Nephropathy
NCT04573478IgA Nephropathy, Immunoglobulin A Nephropathy
DrugsAtrasentan·Zigakibart
Novartis Pharmaceuticals
Phase 3
404
Alabama, California, Florida, Georgia, Illinois, Indiana, Kentucky, Massachusetts
2020-12-11
Active, closed
Placebo-controlled, Study of Concurrent Chemoradiation Therapy With Pembrolizumab Followed by Pembrolizumab and Olaparib in Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK 7339-013/KEYLYNK-013)
NCT04624204Small Cell Lung Cancer
DrugsOlaparib·Keytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
672
Arizona, California, District of Columbia, Florida, Illinois, Indiana, Kentucky, Louisiana
2020-12-08
Active, closed
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Relapsing Multiple Sclerosis (RMS)
NCT04544436Multiple Sclerosis
DrugsOcrelizumab·Methylprednisolone
Hoffmann-La Roche
Phase 3
864
Alabama, Arizona, California, Colorado, Florida, Indiana, Kansas, Louisiana
2020-11-26
Active, closed
Assessing Durvalumab and FLOT Chemotherapy in Resectable Gastric and Gastroesophageal Junction Cancer
NCT04592913Gastrointestinal Neoplasms, Esophagogastric Junction
DrugDurvalumab
AstraZeneca
Phase 3
957
California, Florida, Indiana, Kentucky, Massachusetts, New York, Tennessee, Texas
2020-11-17
Active, closed
AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension
NCT04499248Open-angle Glaucoma, Ocular Hypertension
AbbVie
Phase 1/2
100
Arizona, California, Connecticut, Florida, Georgia, Illinois, Indiana, Massachusetts
2020-11-16
Active, closed
A Study of Adding Apalutamide to Radiotherapy and LHRH Agonist in High-Risk Patients With Hormone-Sensitive Prostate Cancer
NCT04557059Prostatic Neoplasms
DrugsLhrha·Apalutamide
Janssen Pharmaceutica N.V., Belgium
Phase 3
691
Arizona, Arkansas, Colorado, Florida, Indiana, Michigan, New York, Ohio
2020-11-12
Recruiting
The ENCIRCLE Trial
NCT04153292Mitral Regurgitation, Mitral Valve Insufficiency
Edwards Lifesciences
Not applicable
900
Alabama, Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana
2020-11-12
Active, closed
A Study of Amivantamab Subcutaneous (SC) Administration for the Treatment of Advanced Solid Malignancies
NCT04606381Neoplasms
Janssen Research & Development, LLC
Phase 1
158
California, Indiana, New York, Oregon, Tennessee
2020-11-10
Active, closed
A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIa AL Amyloidosis (CARES)
NCT04512235AL Amyloidosis
DrugsAnselamimab·Cyclophosphamide, bortezomib, and dexamethasone (CyBorD)
Alexion Pharmaceuticals, Inc.
Phase 3
281
Arizona, California, Florida, Indiana, Louisiana, Maryland, Massachusetts, Michigan
2020-11-03
Active, closed
The Synergy Disc To Anterior Cervical Discectomy and Fusion
NCT04469231Cervical Degenerative Disc Disease
Synergy Spine Solutions
Not applicable
175
Arizona, California, Colorado, Florida, Indiana, Michigan, New York, North Carolina
2020-10-30
Active, closed
A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Ocrelizumab in Adult Participants With Primary Progressive Multiple Sclerosis
NCT04544449Multiple Sclerosis, Primary Progressive
DrugsFenebrutinib·Ocrelizumab
Hoffmann-La Roche
Phase 3
985
Alabama, California, Colorado, Connecticut, District of Columbia, Florida, Indiana, Kansas
2020-10-26
Active, closed
Recent-Onset Type 1 Diabetes Extension Study Evaluating the Long-Term Safety of Teplizumab (PROTECT Extension)
NCT04598893Diabetes Mellitus, Type 1
DrugTeplizumab
Provention Bio, a Sanofi Company
Observational
188
California, Colorado, Florida, Georgia, Idaho, Indiana, Iowa, Maryland
2020-10-26
Active, closed
Dual-sided Hypoglossal neRvE stimulAtion for the treatMent of Obstructive Sleep Apnea (DREAM)
NCT03868618Obstructive Sleep Apnea
Nyxoah S.A.
Not applicable
115
Alabama, Florida, Georgia, Indiana, Iowa, Massachusetts, New York, Ohio
2020-10-14
Active, closed
A Combination of Acalabrutinib With R-CHOP in Subjects With Previously Untreated Non-GCB DLBCL (ACE-LY-312)
NCT04529772Diffuse Large B-Cell Lymphoma
DrugsAcalabrutinib·Vincristine·Doxorubicin·Prednisone
Acerta Pharma BV
Phase 3
611
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Indiana, Iowa
2020-10-08
Active, closed
A Study of DSP107 Alone and in Combination with Atezolizumab for Patients with Advanced Solid Tumors
NCT04440735Advanced Solid Tumor, Non Small Cell Lung Cancer, Colorectal Cancer
DrugsDSP107·Atezolizumab
Kahr Medical
Phase 1/2
125
California, Colorado, Florida, Indiana, Kansas, Pennsylvania
2020-10-07
Active, closed
Study of LY3410738 Administered to Patients With Advanced Solid Tumors With IDH1 or IDH2 Mutations
NCT04521686Cholangiocarcinoma, Chondrosarcoma, Glioma, Any Solid Tumor
DrugsLY3410738·Durvalumab·Gemcitabine·Cisplatin
Eli Lilly and Company
Phase 1
200
Arizona, California, Florida, Illinois, Indiana, Maryland, Massachusetts, Minnesota
2020-10-01
Active, closed
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-MutatedProstatic Neoplasms (mCSPC)
NCT04497844Prostatic Neoplasms
DrugsAbiraterone acetate·Prednisone
Janssen Research & Development, LLC
Phase 3
696
Alabama, Arizona, California, Colorado, Connecticut, Florida, Indiana, Louisiana
2020-09-23
Recruiting
Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)
NCT04427384Brain Tumor, Recurrent, Brain Tumor, Brain Tumor, Primary, Brain Tumor - Metastatic
GT Medical Technologies, Inc.
Observational
600
Arizona, Arkansas, California, Colorado, Florida, Georgia, Idaho, Indiana
2020-09-11
Active, closed
Study Of Venetoclax Tablet With Intravenous or Subcutaneous Azacitidine to Assess Change in Disease Activity In Adult Participants With Newly Diagnosed Higher-Risk Myelodysplastic Syndrome
NCT04401748Myelodysplastic Syndrome (MDS)
DrugsVenclexta·Azacitidine·Venetoclax
AbbVie
Phase 3
531
California, Colorado, Connecticut, Delaware, Florida, Idaho, Illinois, Indiana
2020-09-10
Active, closed
Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet Versus Best Available Therapy to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis
NCT04468984Myelofibrosis (MF)
DrugsNavitoclax·Ruxolitinib
AbbVie
Phase 3
330
Arizona, Arkansas, California, Colorado, Georgia, Illinois, Indiana, Louisiana
2020-08-31
Active, closed
Oregovomab Plus Chemo in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer Following Optimal Debulking Surgery
NCT04498117Carcinoma, Ovarian Epithelial, Ovarian Neoplasms, Ovarian Cancer, Ovarian Serous Adenocarcinoma
DrugsOregovomab·Paraplatin·Taxol·Paclitaxel
CanariaBio Inc.
Phase 3
615
Arizona, California, Colorado, Connecticut, Florida, Georgia, Hawaii, Indiana
2020-08-25
Active, closed
A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIb AL Amyloidosis (CARES)
NCT04504825AL Amyloidosis
DrugsAnselamimab·Cyclophosphamide, bortezomib, and dexamethasone (CyBorD)
Alexion Pharmaceuticals, Inc.
Phase 3
125
California, Florida, Indiana, Louisiana, Massachusetts, Michigan, Minnesota, Missouri
2020-08-25
Active, closed
A Phase 2 Study of T-DXd in Patients With Selected HER2 Expressing Tumors
NCT04482309Part 1: Bladder, Biliary Tract, Cervical, Endometrial, Ovarian, Pancreatic Cancer, Rare Tumors, Any Tumor Type Excluding Breast, Gastric, Colorectal Cancer, Part 2: HER2 Expressing/Amplified Solid Tumors Excluding Breast, Gastric, Colorectal Cancer
DrugTrastuzumab deruxtecan
AstraZeneca
Phase 2
477
California, Illinois, Indiana, Massachusetts, New Jersey, New York, North Carolina, Texas
2020-08-18
Recruiting
Non-Invasive Quantification of Liver Health in NASH (N-QUAN)
NCT04054310NASH - Nonalcoholic Steatohepatitis
Perspectum
Not applicable
225
Arizona, Illinois, Indiana, New York, Texas, Virginia
2020-08-05
Active, closed
Personalized Therapy Study - Intrinsic Antitachycardia Pacing Post-Approval Study (iATP PAS)
NCT04496518Ventricular Tachycardia
Medtronic
Observational
2,200
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Indiana, Iowa
2020-08-01
Active, closed
Personalized Therapy Study - HFRS (TriageHF) Post Approval Study
NCT04489225Heart Failure
Medtronic
Observational
2,200
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Indiana, Iowa
2020-08-01
Active, closed
Evaluation of Safety and Effectiveness of Stryker Surpass Evolve™ Flow Diverter System
NCT04195568Aneurysm, Intracranial
Stryker Neurovascular
Not applicable
248
Arizona, California, Florida, Illinois, Indiana, Iowa, Kansas, Kentucky
2020-07-07
Active, closed
Study of Pembrolizumab With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib in Stage III Non-Small Cell Lung Cancer (NSCLC) (MK-7339-012/KEYLYNK-012)
NCT04380636Lung Neoplasms, Carcinoma, Non-Small-Cell Lung
DrugsParaplatin·Taxol·Olaparib·Etoposide
Merck Sharp & Dohme LLC
Phase 3
870
Alabama, Arkansas, California, Florida, Indiana, Kentucky, Massachusetts, Michigan
2020-07-06
Active, closed
SELUTION SLR™ 014 In-stent Restenosis
NCT04280029Coronary Restenosis
M.A. Med Alliance S.A.
Not applicable
418
California, Colorado, District of Columbia, Florida, Georgia, Indiana, Kansas, Maryland
2020-07-06
Active, closed
Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension
NCT04273945Pulmonary Arterial Hypertension
DrugMacitentan
Actelion
Phase 3
935
Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana, Iowa
2020-06-30
Active, closed
Chimney EndoVascular Aneurysm Sealing Of New Expanded Indication
NCT042525731 Paravisceral Abdominal Aortic Aneurysm, 2 Juxtarenal Abdominal Aortic Aneurysm, 3 Pararenal Abdominal Aortic Aneurysm, 4 Complex Abdominal Aortic Aneurysms
Endologix
Not applicable
13
Alabama, District of Columbia, Georgia, Indiana, Missouri, New Jersey, New York, Oregon
2020-06-29
Recruiting
An Open-Label Study of INV-1120 as a Single Agent and in Combination With Pembrolizumab in Adult Patients With Advanced Solid Tumors
NCT04443088Cancer, Solid Tumor, Adult, Cancer Metastatic, Solid Carcinoma
Shenzhen Ionova Life Sciences Co., Ltd.
Phase 1
78
Indiana, Texas
2020-06-26
Active, closed
A Long-term Extension Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease
NCT04232553Crohn's Disease
DrugMirikizumab
Eli Lilly and Company
Phase 3
996
Alabama, Arizona, California, Connecticut, Florida, Georgia, Idaho, Indiana
2020-06-22
Active, closed
A Study to Assess Overall Response Rate by Inducing an Inflammatory Phenotype in Metastatic BReast cAnCEr With the Oncolytic Reovirus PeLareorEp in CombinaTion With Anti-PD-L1 Avelumab and Paclitaxel - BRACELET-1 Study
NCT04215146Breast Cancer Metastatic
DrugsPelareorep·Avelumab·Paclitaxel
Oncolytics Biotech
Phase 2
48
Florida, Illinois, Indiana, Louisiana, Missouri, New Jersey, New York, Ohio
2020-06-10
Recruiting
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
NCT04389632Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck, HER2 Negative Breast Neoplasms, Esophageal Squamous Cell Carcinoma
DrugsSigvotatug vedotin·Keytruda·Cisplatin·Carboplatin
Seagen, a wholly owned subsidiary of Pfizer
Phase 1
1,006
Alaska, Arkansas, California, Florida, Illinois, Indiana, Kansas, Massachusetts
2020-06-08
Active, closed
Post-approval Registry Study to Evaluate the Continued Safety and Probable Benefit of the MID-C System for 5 Years Post-Implantation in Adolescent Idiopathic Scoliosis (AIS)
NCT04296903Adolescent Idiopathic Scoliosis
Apifix
Not applicable
201
California, Florida, Georgia, Indiana, Kansas, Minnesota, Mississippi, Missouri
2020-05-31
Active, closed
Evaluation of MN-166 (Ibudilast) for 12 Months Followed by an Open-label Extension for 6 Months in Patients With ALS
NCT04057898Amyotrophic Lateral Sclerosis
MediciNova
Phase 2/3
234
California, Florida, Georgia, Indiana, Maryland, Minnesota, New York, North Carolina
2020-05-28
Active, closed
Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer
NCT04269200Endometrial Neoplasms
DrugsOlaparib·Durvalumab·Paclitaxel·Carboplatin
AstraZeneca
Phase 3
805
Arizona, California, Colorado, Florida, Georgia, Hawaii, Illinois, Indiana
2020-05-05
Recruiting
Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body
NCT04142437Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene Fusion
DrugLarotrectinib
Bayer
Observational
150
Arizona, California, Colorado, Connecticut, Florida, Indiana, Kansas, Maine
2020-04-03
Recruiting
CERAMENT™| Bone Void Filler Device Registry
NCT04244942Orthopedic Disorder
BONESUPPORT AB
Observational
300
Arizona, Florida, Indiana, Kentucky, Massachusetts, New York, North Carolina, Ohio
2020-03-30
Active, closed
A Study to Evaluate Enfortumab Vedotin in Subjects With Locally Advanced or Metastatic Malignant Solid Tumors (EV-202)
NCT04225117Locally Advanced or Metastatic Malignant Solid Tumors
DrugsEnfortumab Vedotin·Keytruda·Pembrolizumab
Astellas Pharma Global Development, Inc.
Phase 2
329
Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana, Kansas
2020-03-10
Recruiting
Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer
NCT04221542Prostate Cancer
DrugsXaluritamig·Abiraterone·Enzalutamide
Amgen
Phase 1
479
California, Colorado, Connecticut, Georgia, Indiana, Kansas, Louisiana, Missouri
2020-03-04
Active, closed
FemBloc® Permanent Contraception - Confirmation Feasibility Trial
NCT04273594Contraception
Femasys Inc.
Not applicable
45
Arizona, Georgia, Indiana, Michigan, Ohio
2020-02-27
By invitation
Global Utilization And Registry Database for Improved heArt preservatioN
NCT04141605Heart Diseases, Heart Failure, Heart Defects, Congenital
Paragonix Technologies
Observational
3,000
California, District of Columbia, Florida, Indiana, Kansas, Massachusetts, Michigan, New York
2020-02-14
Active, closed
A Study in Which Non-metastatic Castration-resistant Prostate Cancer (nmCRPC) Patients for Whom a Decision to Treat With Darolutamide Has Been Made Before Enrollment Are Observed and Certain Outcomes Are Described
NCT04122976Prostate Cancer
DrugDarolutamide
Bayer
Observational
805
Alabama, Arizona, California, Colorado, Florida, Illinois, Indiana, Kansas
2020-01-30
Active, closed
Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy
NCT03970343Heart Failure
Impulse Dynamics
Observational
620
Arizona, California, Colorado, District of Columbia, Florida, Georgia, Illinois, Indiana
2020-01-21
Active, closed
A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension
NCT04175600Hypertension, Pulmonary
DrugSelexipag
Actelion
Phase 3
138
Arizona, California, Colorado, District of Columbia, Florida, Indiana, Michigan, Ohio
2020-01-16
Active, closed
Open-Label Extension: Tolerability and Effects of ALK-001 on Stargardt Disease (TEASE)
NCT04239625Stargardt Disease, Stargardt Macular Degeneration, Stargardt Macular Dystrophy, Autosomal Recessive Stargardt Disease 1 (ABCA4-related)
DrugALK-001
Alkeus Pharmaceuticals, Inc.
Phase 2
200
Arizona, California, Colorado, Florida, Indiana, Michigan, New York, Washington
2019-12-20
Active, closed
Transforaminal Lumbar Interbody Fusion (TLIF)
NCT04073563Degenerative Disease of the Lumbosacral Spine
Medtronic Spinal and Biologics
Not applicable
600
Arizona, California, Colorado, Connecticut, Florida, Illinois, Indiana, Iowa
2019-12-19
Active, closed
Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101)
NCT04185883Advanced Solid Tumors, Kirsten Rat Sarcoma (KRAS) pG12C Mutation
DrugsBI 1701963·TNO155·Sotorasib·Afatinib
Amgen
Phase 1
610
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana
2019-12-17
Recruiting
Terumo Aortic Global Endovascular Registry
NCT04246463Abdominal Aortic Aneurysm, Thoracic Aortic Aneurysm, Surgery
Vascutek Ltd.
Observational
1,000
California, Colorado, Connecticut, District of Columbia, Florida, Illinois, Indiana, Michigan
2019-12-17
Active, closed
Neuspera's Implantable Sacral Nerve Stimulation System in Patients With Symptoms of Urinary Urgency Incontinence (UUI)
NCT04232696Urinary Urgency Incontinence
Neuspera Medical, Inc.
Not applicable
331
California, Florida, Georgia, Illinois, Indiana, Kansas, Kentucky, Louisiana
2019-12-13
Active, closed
Prophylactic Reinforcement of Ventral Abdominal Incisions Trial
NCT03911700Open Midline Laparotomy
C. R. Bard
Not applicable
477
Arizona, California, Connecticut, Georgia, Illinois, Indiana, Kentucky, Louisiana
2019-12-12
Recruiting
Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial
NCT04097145Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease
Edwards Lifesciences
Not applicable
1,270
Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana, Iowa
2019-12-11
Active, closed
A Study of LY3484356 in Participants With Advanced or Metastatic Breast Cancer or Endometrial Cancer
NCT04188548Breast Cancer, Advanced Breast Cancer, Metastatic Breast Cancer, Endometrial Cancer
DrugsImlunestrant·Alpelisib·Everolimus·Abemaciclib
Eli Lilly and Company
Phase 1
379
Arizona, Arkansas, California, Florida, Georgia, Indiana, Maryland, Massachusetts
2019-12-10
Active, closed
M6-C Post Approval Study (PAS)
NCT04122248Cervical Degenerative Disc Disease, Cervical Radiculopathy, Cervical Spinal Cord Compression, Cervical Disc Herniation
Spinal Kinetics
Observational
152
Arizona, California, Colorado, Connecticut, District of Columbia, Illinois, Indiana, Louisiana
2019-11-30
Active, closed
OCS DCD Heart + CAP Continued Follow-Up
NCT05741723Heart Transplant
TransMedics
Observational
276
California, Connecticut, Florida, Georgia, Illinois, Indiana, Massachusetts, Minnesota
2019-11-26
Recruiting
Abbott DBS Post-Market Study of Outcomes for Indications Over Time
NCT04071847Movement Disorders, Parkinson Disease, Essential Tremor, Tremor
Abbott Medical Devices
Observational
1,000
Arizona, California, Colorado, Florida, Illinois, Indiana, Kansas, Kentucky
2019-11-26
Active, closed
A Study of Tyrosine Kinase Inhibitor Orelabrutinib (ICP-022) in Patients With r/r B-Cell Malignancies
NCT04014205Part 1：r/r B-cell Malignancies, Part 2：B-cell Malignancies
DrugOrelabrutinib
Beijing InnoCare Pharma Tech Co., Ltd.
Phase 1/2
81
Arizona, California, Florida, Illinois, Indiana, Kansas, Louisiana, Maryland
2019-11-18
Active, closed
Research Study to Look at How Well the Drug Concizumab Works in Your Body if You Have Haemophilia Without Inhibitors
NCT04082429Haemophilia A Without Inhibitors, Haemophilia B Without Inhibitors
DrugConcizumab
Novo Nordisk A/S
Phase 3
156
California, Georgia, Indiana, Iowa, Michigan, North Carolina, Pennsylvania, Tennessee
2019-11-13
Active, closed
A Study of JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Participants With Multiple Myeloma
NCT04133636Multiple Myeloma
DrugsCilta-cel·Bortezomib·Daratumumab·Lenalidomide
Janssen Research & Development, LLC
Phase 2
208
California, Connecticut, Florida, Georgia, Illinois, Indiana, Iowa, Kansas
2019-11-07
Active, closed
Pediatric Long-Term Follow-up and Rollover Study
NCT03975829Diffuse Astrocytoma, Anaplastic Astrocytoma, Astrocytoma, Oligodendroglioma, Childhood
DrugsDabrafenib·Trametinib
Novartis Pharmaceuticals
Phase 4
163
Arizona, District of Columbia, Florida, Indiana, Maryland, Massachusetts, Minnesota, New York
2019-11-04
Active, closed
Research Study to Look at How Well the Drug Concizumab Works in Your Body if You Have Haemophilia With Inhibitors
NCT04083781Haemophilia A With Inhibitors, Haemophilia B With Inhibitors
DrugConcizumab
Novo Nordisk A/S
Phase 3
134
California, Georgia, Indiana, Missouri, North Carolina, Tennessee, Texas
2019-10-21
Active, closed
Nous-209 Genetic Vaccine for the Treatment of Microsatellite Unstable Solid Tumors
NCT04041310Solid Tumor, Adult
DrugsKeytruda·Pembrolizumab
Nouscom SRL
Phase 1/2
115
California, Florida, Indiana, Maryland, Missouri, New York, Texas
2019-10-21
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Cite this view

Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 6 October 2026. https://priyalifescience.com/clinical-trials-usa/state/indiana?page=2

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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every industry-sponsored study on the registry that lists at least one investigative site in the US and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 9,118 studies in total at the last sync on 06 Oct 2026, 03:16 UTC. Academic and other non-industry sponsors are out of scope by design. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 1,124 of those studies with a site in Indiana.

How many clinical trials are recruiting in Indiana?

558 of the 1,124 studies on this page are recruiting new participants as of the 06 Oct 2026, 03:16 UTC sync. A further 19 have not yet opened recruitment, 522 are active but closed to new participants, and 25 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Listing here is informational and not medical advice; eligibility is determined by each study team. Compare pay for the teams running these studies in the US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish, UK and EU sites, see the Ireland, UK and EU registers.