Hydroxyurea is named as an intervention in 4 current clinical trials in our UK, USA, Ireland, China and India registers. 3 are recruiting patients now. The most common phase is Phase 3. The sponsor with the most trials is Italfarmaco (1). The most-studied condition is Polycythemia Vera.
| Study | Phase | Status | Lead sponsor | Registers |
|---|---|---|---|---|
|
Study on Efficacy and Safety of Givinostat Versus Hydroxyurea in Patients With Polycythemia Vera
NCT06093672 · Polycythemia Vera
|
Phase 3 | Recruiting | Italfarmaco | Ireland, UK, USA |
|
A Phase 2 Open-label Study to Evaluate the Activity of Etavopivat on Transcranial Doppler Velocities in Pediatric Patients With Sickle Cell Disease Who Are at Increased Risk for Primary Stroke
NCT05953584 · ClinicalTrials.gov ↗ · Sickle Cell Disease
|
Phase 2 | Recruiting | Forma Therapeutics, Inc. | India |
|
Pacritinib vs. Hydroxyurea in Advanced Proliferative Chronic Myelomonocytic Leukemia
NCT07033598 · ClinicalTrials.gov ↗ · Leukemia, Myelomonocytic, Chronic
|
Phase 2 | Recruiting | Theradex | UK, USA |
|
Bomedemstat vs Hydroxyurea for Essential Thrombocythemia (MK-3543-007)
NCT06456346 · ClinicalTrials.gov ↗ · Essential Thrombocythemia
|
Phase 3 | Active, closed | Merck Sharp & Dohme LLC | UK, USA, China |
Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.
| Lead sponsor | Trials |
|---|---|
| Italfarmaco | 1 |
| Theradex | 1 |
| Merck Sharp & Dohme LLC | 1 |
| Forma Therapeutics, Inc. | 1 |
| Register | Trials | Recruiting |
|---|---|---|
| Clinical trials in UK | 3 | 2 |
| Clinical trials in USA | 3 | 2 |
| Clinical trials in Ireland | 1 | 1 |
| Clinical trials in China | 1 | 0 |
| Clinical trials in India | 1 | 1 |
A trial with sites in more than one country appears in each of those registers.
4 current trials in our UK, USA, Ireland, China and India registers name Hydroxyurea as a drug or biological intervention, as of the registry sync on 25 September 2026. Completed and withdrawn studies are not counted.
Yes. 3 of the 4 trials are recruiting: 2 with sites in UK, 2 with sites in USA, 1 with sites in Ireland and 1 with sites in India. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.
Italfarmaco (1), Theradex (1), Merck Sharp & Dohme LLC (1) and Forma Therapeutics, Inc (1). The number in brackets is how many trials each organisation leads.
Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Hydroxyurea works or whether it is effective, and it is not medical advice.
Everything on this page is copied from public ClinicalTrials.gov registry records โ it is not written from memory, and nothing here describes how Hydroxyurea works or whether it is effective. Each trial links to its own record so you can check it yourself.
This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Hydroxyurea (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 25 Sep 2026.