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Updated 11 Sep 2026 · ClinicalTrials.gov

Clinical Trials in the USA

The most recently updated industry-sponsored clinical trials recruiting across the United States — searchable by condition, sponsor, phase and state. Refreshed daily from the ClinicalTrials.gov registry.

111
Recruiting now
160
Studies tracked
45
States with sites
Active Phase 3
Determine Effectiveness of Anifrolumab In SYstemic Sclerosis (DAISY)
Systemic Sclerosis, Scleroderma
AstraZeneca · started 2023-11-08
Arizona · California · Colorado · Connecticut · District of Columbia · Florida · Illinois · Kansas
NCT05925803 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer
Metastatic Breast Cancer
Hoffmann-La Roche · started 2018-03-30
California · Colorado · Florida · Illinois · Minnesota · Nevada · New Jersey · New York
NCT03424005 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC
Epidermal Growth Factor, Epidermal Growth Factor Receptor, Epidermal Growth Factor Receptor Gene Mutation, Non Small Cell
EpiBiologics · started 2026-03-31
California · New Jersey · New York · Tennessee · Texas
NCT07462377 on ClinicalTrials.gov ↗
By invitation Phase 2/Phase 3
HELIOS: Open-Label, Long-Term Extension Study to Investigate the Safety, Tolerability, and Efficacy of DISC-1459 (Bitopertin) in Participants With EPP or XLP
Erythropoietic Protoporphyria
Disc Medicine, Inc · started 2023-08-31
Alabama · California · Florida · Massachusetts · New York · North Carolina · Ohio · Pennsylvania
NCT05883748 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
GPC3-Targeted T-Cell Therapy (ECT204) in Adults With Advanced HCC
Hepatocellular Carcinoma, Liver Cancer, Adult, Liver Neoplasm, Metastatic Liver Cancer
Eureka Therapeutics Inc. · started 2022-03-11
California · Kansas · New York · Oregon · Texas · Washington
NCT04864054 on ClinicalTrials.gov ↗
Recruiting Phase 3
CardiolRx in Recurrent Pericarditis (MAVERIC Phase-3)
Recurrent Pericarditis
Cardiol Therapeutics Inc. · started 2025-04-07
Arizona · California · Florida · Illinois · Maryland · Massachusetts · Minnesota · New York
NCT06708299 on ClinicalTrials.gov ↗
Recruiting
Stereotactic Adaptive Radiation Therapy of Borderline Resectable Pancreatic Cancer an Individualized Approach
Pancreatic Cancer
Varian, a Siemens Healthineers Company · started 2023-05-14
Alabama · California · Missouri · Ohio
NCT05764720 on ClinicalTrials.gov ↗
Recruiting Phase 1
Safety and Immunogenicity of V540B in Healthy Adults (V540B-002).
Healthy
Merck Sharp & Dohme LLC · started 2024-11-12
California · Florida · Nebraska
NCT06623409 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study to Assess the Skin Irritation and Sensitization of Estradiol/Levonorgestrel TDS in Healthy Postmenopausal Subjects
Menopause, Healthy Female Participants
Corium Innovations, Inc. · started 2026-08-10
Nevada
NCT07794150 on ClinicalTrials.gov ↗
Active Phase 1/Phase 2
A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies
Acute Leukemia, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Acute Biphenotypic Leukemia
Ossium Health, Inc. · started 2024-08-16
California · Florida · Georgia · Michigan · Oregon · Tennessee · Texas · Utah
NCT05589896 on ClinicalTrials.gov ↗
Recruiting Phase 1
A First-in-Human Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of HMB-003 in Healthy Volunteers
Healthy Adult Participants
Hemab ApS · started 2026-08-17
Texas
NCT07798505 on ClinicalTrials.gov ↗
Recruiting Phase 2
Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Chronic Inflammatory Demyelinating Polyneuropathy
Immunovant Sciences GmbH · started 2025-03-18
Arizona · California · Colorado · Connecticut · District of Columbia · Florida · Illinois · Kansas
NCT07032662 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Trontinemab in Cognitively Unimpaired Individuals at Risk for Progression to Symptomatic Alzheimer's Disease
Alzheimer's Disease
Hoffmann-La Roche · started 2026-11-30
California · Florida · New York
NCT07717411 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study of PARG Inhibitor FORX-428 in Patients With Advanced Solid Tumors.
Advanced Solid Tumors
FoRx Therapeutics AG · started 2025-07-22
California · Michigan · Missouri · Oregon · Texas · Virginia
NCT07356453 on ClinicalTrials.gov ↗
Starting soon Phase 1/Phase 2
Safety and Efficacy Study of GEB-101 Injection in Subjects With TGFBI-related Corneal Dystrophy
Hereditary Corneal Dystrophy, Corneal Abnormality, Corneal Dystrophies, Corneal Dystrophies, Hereditary
GenEditBio Limited · started 2026-10
California
NCT07750678 on ClinicalTrials.gov ↗
Recruiting Phase 2
The Purpose of This Study is to Evaluate Efficacy and Safety of NT-101 Eye Drops in Patients With Wet Age-Related Macular Degeneration (AMD)
Wet Age Related Macular Degeneration
NexThera Co., Ltd. · started 2026-06-11
Florida · Oklahoma · Pennsylvania
NCT07811726 on ClinicalTrials.gov ↗
Active Phase 1
A Study to See How Metabolism is Influenced by Weight Loss Due to Intervention With Cagrilintide and Semaglutide Compared to Diet
Obesity
Novo Nordisk A/S · started 2025-09-26
Florida · Louisiana
NCT07184086 on ClinicalTrials.gov ↗
Recruiting Phase 3
Efficacy and Safety of Intranasal Cenegermin in Adult Participants With Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)
Non-Arteritic Anterior Ischemic Optic Neuropathy
Dompé Farmaceutici S.p.A · started 2026-07-01
California · Colorado · Florida · Georgia · Illinois · Kentucky · Maryland · Massachusetts
NCT07453888 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms
Neoplasms
Janssen Research & Development, LLC · started 2023-12-20
California · Colorado · Florida · Georgia · Michigan · New Jersey · New York · North Carolina
NCT06150157 on ClinicalTrials.gov ↗
Active Phase 1
A Study of JZP815 Oral Capsules in Adult Participants With Advanced or Metastatic Solid Tumors Harboring Mitogen Activated Protein Kinase (MAPK) Pathway Alterations to Investigate the Safety, Dosing, and Antitumor Activity of JZP815
Advanced Cancer, Metastatic Cancer, Solid Tumor, Melanoma
Jazz Pharmaceuticals · started 2022-10-10
California · Colorado · Florida · Illinois · New York · Oklahoma · Pennsylvania · Tennessee
NCT05557045 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (PD) Participants With Motor Fluctuations
Parkinson Disease
Appello Pharmaceuticals, Inc. · started 2026-02-25
Arkansas · California · Colorado · Florida · Georgia · Indiana · Kansas · Kentucky
NCT07432958 on ClinicalTrials.gov ↗
Starting soon Phase 1/Phase 2
A Study of AL58805 in Advanced, Metastatic GYN, STS or Breast Cancers
Endometrial Neoplasms, Soft Tissue Sarcoma (STS), Breast Neoplasms
Advenchen Pharmaceuticals, LLC. · started 2026-09-01
Texas
NCT07811232 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Orelabrutinib in Patients With Secondary Progressive Multiple Sclerosis
Secondary Progressive Multiple Sclerosis
Zenas BioPharma (USA), LLC · started 2026-03-23
Arizona · California · Florida · Indiana · Kansas · Massachusetts · Michigan · Missouri
NCT07299019 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
Advanced Non-small Cell Lung Cancer, HER2 Mutation
Bayer · started 2024-08-28
California · Florida · Georgia · Illinois · Maryland · Massachusetts · Michigan · Minnesota
NCT06452277 on ClinicalTrials.gov ↗
Recruiting Phase 3
Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM
Glioblastoma, Recurrent Glioblastoma, GBM
CarThera · started 2024-01-29
Arizona · California · Colorado · Florida · Georgia · Illinois · Indiana · Maryland
NCT05902169 on ClinicalTrials.gov ↗
By invitation
Multimodal Physiologic State Intelligence Study
Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
Truway Health, Inc. · started 2026-09-02
New York
NCT07814118 on ClinicalTrials.gov ↗
Recruiting Phase 3
Evenamide, a Glutamate Release Modulator, as Add-On to Standard of Care in Subjects With Documented Treatment-Resistant Schizophrenia
Treatment-resistant Schizophrenia
Newron Pharmaceuticals SPA · started 2026-01-23
California · Florida · Georgia · Maryland · New York
NCT07184619 on ClinicalTrials.gov ↗
Recruiting Phase 3
BEACON - Phase III Clinical Study of Rugonersen in Angelman Syndrome.
Angelman Syndrome
OHB Pediatrics Ltd. · started 2026-06-23
California · Illinois · North Carolina
NCT07605429 on ClinicalTrials.gov ↗
Recruiting
Abbott Cephea Mitral Valve Disease Registry
Mitral Regurgitation, Mitral Stenosis, Mitral Valve Disease, Mitral Valve (MV) Regurgitation
Abbott Medical Devices · started 2025-08-13
Alabama · Arizona · California · Georgia · Illinois · Indiana · Kansas · Minnesota
NCT07069673 on ClinicalTrials.gov ↗
Active
Evaluation of Cemiplimab in Combination With Platinum-Doublet Chemotherapy in First-Line (1L) Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC) in Adult United States (US) Participants
Advanced Non-small Cell Lung Cancer
Regeneron Pharmaceuticals · started 2024-02-21
New York
NCT06269133 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Non-Small Cell Lung Cancer
Non-Small Cell Lung Cancer
Verastem, Inc. · started 2026-07-22
California · Georgia · New Jersey · New York · Texas · Virginia
NCT07659782 on ClinicalTrials.gov ↗
Recruiting Phase 2
Trial Comparing the Safety and Efficacy of Two Different Oral VPV Doses With Placebo as Treatment for RV in Participants With COPD
Rhinovirus Infection
Altesa Biosciences, Inc. · started 2026-05-01
Alabama · Arizona · California · Florida · Georgia · Illinois · Indiana · Kentucky
NCT07610395 on ClinicalTrials.gov ↗
Active Phase 2
A Phase 2 Study to Evaluate the Pharmacodynamics, Safety and Tolerability of BGE-102 in Participants With Obesity and Cardiovascular Risk Factors
Obesity and Cardiovascular Risk
BioAge Labs, Inc. · started 2026-06-11
Arizona · Arkansas · Florida · Kentucky · Maryland · Missouri · Nevada · New York
NCT07656727 on ClinicalTrials.gov ↗
Active Phase 2
A Study of Tobemstomig + Nab-Paclitaxel Compared With Pembrolizumab + Nab-Paclitaxel in Participants With Previously Untreated, PD-L1-Positive, Locally-Advanced Unresectable or Metastatic Triple-Negative Breast Cancer
Breast Cancer
Hoffmann-La Roche · started 2023-07-18
California · New York · North Carolina · South Dakota
NCT05852691 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE
Lupus Erythematosus, Systemic
AstraZeneca · started 2025-04-21
California · Florida · Georgia · Illinois · Maryland · Massachusetts · Missouri · New York
NCT06897930 on ClinicalTrials.gov ↗
Active Phase 1
A Dose Finding Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Glioblastoma in Combination With Standard of Care and in Recurrent Glioblastoma as a Single Agent.
Glioblastoma
Novartis Pharmaceuticals · started 2022-05-10
New York · Pennsylvania · Texas · Wisconsin
NCT05109728 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
Surabgene Lomparvovec Administered in the Suprachoroidal Space in Adult Participants With Diabetic Retinopathy Without Center-Involved Diabetic Macular Edema
Diabetic Retinopathy
AbbVie · started 2026-06-01
Arizona · California · Colorado · Florida · Georgia · Illinois · Kansas · Maine
NCT07592273 on ClinicalTrials.gov ↗
Recruiting Phase 1
Safety, Pharmacokinetics, and Preliminary Efficacy of VIR-5500 (AMX-500) in Prostate Cancer
Hormone-refractory Prostate Cancer
Astellas Pharma Global Development, Inc. · started 2023-08-10
California · Texas · Virginia · Washington
NCT05997615 on ClinicalTrials.gov ↗
Recruiting Phase 3
Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of Investigator's Choice as First-line Treatment in Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma ( RASolute 305 )
Pancreatic Cancer, Pancreatic Cancer Metastatic, PDAC, PDAC - Pancreatic Ductal Adenocarcinoma
Revolution Medicines, Inc. · started 2026-05-22
Arizona · Connecticut · Florida · Georgia · Illinois · Maryland · Massachusetts · New Jersey
NCT07621718 on ClinicalTrials.gov ↗
Starting soon Phase 1/Phase 2
A Phase 1/2 Trial of ADI-212 in mCRPC
Prostate Cancer Metastatic
Adicet Therapeutics · started 2026-09
California
NCT07793435 on ClinicalTrials.gov ↗
Starting soon
Reduction of Depression Through Dual Treatment: Digital CBT & NBHWC Coaching
Hearing Disability, Depression, Mobility Disability
Toivoa Inc · started 2026-09
Delaware · New Jersey · Ohio · Texas
NCT07195292 on ClinicalTrials.gov ↗
Recruiting Phase 3
Pivotal Open-label Phase 3 Clinical Study of QTX-2101 in Adult Patients With Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia (APL), Acute Promyelocytic Leukaemia, Acute Promyelocytic Leukemia With PML-RARA, Acute Promyelocytic Leukemia With t(15;17)(q24.1;q21.2); PML-RARA
Quetzal Therapeutics · started 2026-06-08
Alabama · California · Georgia · Kentucky · Maryland · Michigan · New York · Ohio
NCT07504458 on ClinicalTrials.gov ↗
Active Phase 1/Phase 2
A Phase 1/2 Trial of ADI-270 in ccRCC
Clear Cell Renal Cell Carcinoma
Adicet Therapeutics · started 2024-12-12
California
NCT06480565 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors
MTAP-deleted Solid Tumors
Bayer · started 2025-03-21
Alabama · California · Colorado · Florida · Massachusetts · Michigan · New York · Tennessee
NCT06914128 on ClinicalTrials.gov ↗
Active Phase 2
A Study of Mosliciguat in PH-ILD
Pulmonary Hypertension, Interstitial Lung Disease, Lung Diseases, Vascular Diseases
Pulmovant, Inc. · started 2024-10-29
Arizona · California · District of Columbia · Florida · Illinois · Iowa · Kansas · Kentucky
NCT06635850 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study of KK2269 in Adult Participants With Solid Tumors
Advanced Solid Tumor, Metastatic Solid Tumor, Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
Kyowa Kirin Co., Ltd. · started 2024-01-18
Arizona · California · Florida · Missouri · Texas · Washington
NCT06266299 on ClinicalTrials.gov ↗
Active Phase 3
A Study of NT 201 in Adults With Moderate to Severe Platysma Prominence in the United States
Neuromuscular Agents, Peripheral Nervous System Agents, Physiological Effects of Drugs, Acetylcholine Release Inhibitors
Merz North America, Inc. · started 2025-08-27
Arizona · California · Colorado · Connecticut · District of Columbia · Florida · Georgia · Illinois
NCT07122193 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune Disease
Systemic Lupus Erythematosus (With and Without Nephritis), Idiopathic Inflammatory Myopathy, Systemic Sclerosis
Allogene Therapeutics · started 2025-11-13
Arizona · California · Colorado · Florida · Illinois · Iowa · Kansas · Kentucky
NCT07085104 on ClinicalTrials.gov ↗
Recruiting
Onyx™ Liquid Embolic IDE Clinical Study
Peripheral Arterial Hemorrhage, Trauma, GI Bleed, Ulcer
Medtronic Endovascular · started 2025-05-09
Arizona · California · Colorado · Connecticut · Illinois · Iowa · Massachusetts · Nebraska
NCT06742801 on ClinicalTrials.gov ↗
Recruiting Phase 1
Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors
Endometrial Cancer, Cervical Cancer, Ovarian Cancer, Urothelial Carcinoma
SystImmune Inc. · started 2024-02-09
Alabama · California · Florida · Georgia · Illinois · Massachusetts · Michigan · Missouri
NCT06293898 on ClinicalTrials.gov ↗
Recruiting
Neutrophil and Monocyte Deactivation Via the SeLective CytopheretIc Device - A Randomized Clinical Trial in Acute Kidney Injury
Acute Kidney Injury
SeaStar Medical · started 2023-04-17
Alabama · Arizona · California · Colorado · Florida · Georgia · Iowa · Kentucky
NCT05758077 on ClinicalTrials.gov ↗
Active Phase 2
A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors
Ovarian Cancer
Hoffmann-La Roche · started 2021-10-07
California · Missouri · North Carolina · Ohio · Oklahoma · Texas · Virginia · Washington
NCT04931342 on ClinicalTrials.gov ↗
Starting soon
An Observational Study of Patients With Dermatologic Disease
Vitiligo, Atopic Dermatitis, Alopecia Areata, Hidradenitis Suppurativa (HS)
Target PharmaSolutions, Inc. · started 2026-09
New York
NCT07748169 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Trial of the Efficacy and Safety of a Fixed Dose of SEP-363856 in Adults With Generalized Anxiety Disorder
Generalized Anxiety Disorder
Otsuka Pharmaceutical Development & Commercialization, Inc. · started 2026-08-06
California · Florida · New Jersey · New York · Washington
NCT07767903 on ClinicalTrials.gov ↗
Active
Evaluation of the GORE® TBE Device in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta, Zone 0/1
Aortic Aneurysm, Thoracic, Aorta, Lesion
W.L.Gore & Associates · started 2016-08
California · Connecticut · District of Columbia · Florida · Georgia · Illinois · Indiana · Maryland
NCT02777528 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension
Uncontrolled Hypertension
Retension Pharmaceuticals. Inc. · started 2025-10-31
Alabama · Arizona · California · Connecticut · Florida · Georgia · Massachusetts · Nevada
NCT07142356 on ClinicalTrials.gov ↗
By invitation
Clinical Time and Temporal Dynamics Study (CLIN-TIME)
Longitudinal Studies, Prospective Studies, Biomarkers, Predictive Value of Tests
Truway Health, Inc. · started 2026-09-01
New York
NCT07812831 on ClinicalTrials.gov ↗
Active Phase 2
A Study to Test Whether BI 3034701 Helps People to Lose Weight Who Live With Obesity or Overweight
Obesity, Overweight
Boehringer Ingelheim · started 2026-06-30
Alabama · California · Florida · Georgia · Kentucky · Michigan · Missouri · North Carolina
NCT07662122 on ClinicalTrials.gov ↗
Recruiting Phase 2
FOLFIRI and Bevacizumab With or Without Pelareorep for Second-Line Treatment of Metastatic RAS-Mutated, Microsatellite-Stable Colorectal Cancer
Ras-mutated Metastatic Colorectal Cancer, mCRC, MSS Metastatic Colorectal Cancer
Oncolytics Biotech · started 2026-04-30
Alabama · California · Georgia · Idaho · Indiana · Missouri · New Jersey · Ohio
NCT07446322 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Phase III Study to Assess the Effect of FDC Laroprovstat/Rosuvastatin Compared With Laroprovstat, Rosuvastatin and Placebo on LDL-C in LLT-naïve Patients.
Hypercholesterolaemia
AstraZeneca · started 2026-08-12
Alabama · Arizona · California · Colorado · Connecticut · Florida · Georgia · Illinois
NCT07619131 on ClinicalTrials.gov ↗
Recruiting Phase 1
Phase 1 Study of a Self-amplifying RNA Vaccine (ITI-5000) in Stage 2-3 Triple Negative Breast Cancer
Triple Negative Breast Cancer (TNBC)
Immunomic Therapeutics, Inc. · started 2026-07-14
Michigan · Tennessee
NCT07652242 on ClinicalTrials.gov ↗
Recruiting Phase 3
An Efficacy and Safety Study of Intravenous Anifrolumab to Treat Systemic Lupus Erythematosus in Pediatric Participants
Systemic Lupus Erythematosus
AstraZeneca · started 2024-03-14
Arizona · California · District of Columbia · Illinois · Louisiana · Maryland · Minnesota · New York
NCT05835310 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Evaluate Efficacy, Safety, and Tolerability of Remibrutinib in Adult Participants With Severe Chronic Pruritus of Unknown Origin (CPUO)
Chronic Pruritus of Unknown Origin
Novartis Pharmaceuticals · started 2026-10-06
Massachusetts
NCT07811869 on ClinicalTrials.gov ↗
Starting soon Phase 1/Phase 2
A Study of Catequentinib Hydrochloride (AL3818) in Endometrial, LGSOC, STS or GBM Cancers
Endometrial Neoplasms, Ovarian Neoplasms, Soft Tissue Sarcoma (STS), Glioblastoma
Advenchen Pharmaceuticals, LLC. · started 2026-09-01
Texas
NCT07811297 on ClinicalTrials.gov ↗
Starting soon Phase 2/Phase 3
Comparison of Cerebraca Wafer Plus Temozolomide Versus Temozolomide Alone in Recurrent Glioblastoma
Recurrent Glioblastoma, IDH-Wildtype
Everfront Biotech Co., Ltd. · started 2027-04-01
Rhode Island
NCT07349693 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study of GEN1106 in Participants With Solid Tumors
Solid Tumors, Urothelial Carcinoma
Genmab · started 2026-04-14
Connecticut · New York · South Carolina · Tennessee · Texas
NCT07416123 on ClinicalTrials.gov ↗
Active Phase 2
A Study Evaluating APG777 in Atopic Dermatitis
Atopic Dermatitis
Apogee Therapeutics, Inc. · started 2024-04-29
California · Connecticut · Florida · Georgia · Illinois · Indiana · Kentucky · Maryland
NCT06395948 on ClinicalTrials.gov ↗
Active Phase 2
Study of Efficacy and Safety of JDQ443 Single-agent as First-line Treatment for Patients With Locally Advanced or Metastatic KRAS G12C- Mutated Non-small Cell Lung Cancer With a PD-L1 Expression < 1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation.
Locally Advanced or Metastatic KRAS G12C-mutated NSCLC With a PD-L1 Expression <1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation
Novartis Pharmaceuticals · started 2022-12-06
Rhode Island
NCT05445843 on ClinicalTrials.gov ↗
Recruiting Phase 2
Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD
Geographic Atrophy (GA), Age - Related Macular Degeneration (AMD)
ONL Therapeutics · started 2025-10-28
Arizona · California · Colorado · Connecticut · Florida · Illinois · Indiana · Maryland
NCT06659445 on ClinicalTrials.gov ↗
Recruiting Phase 4
Abuse Potential of Gabapentin Taken Orally Concomitantly With Oxycodone Hydrochloride in Healthy, Non-Drug-Dependent, Recreational Opioid Users
Healthy, Non-Drug- Dependent, Recreational Opioid Users
Viatris Inc. · started 2026-08-03
Kansas
NCT07813026 on ClinicalTrials.gov ↗
Recruiting
Examination of Nociscan Impact on Low Back Pain Surgical Outcomes
Low Back Pain
Aclarion · started 2025-06-11
Arizona · California · Florida · Illinois · Maryland · Texas
NCT06661850 on ClinicalTrials.gov ↗
Recruiting Phase 3
Pridopidine Phase 3 Study in Huntington's Disease
Huntington Disease
Prilenia · started 2026-07-01
Alabama · California · District of Columbia · Florida · Illinois · Kansas · Maryland · Massachusetts
NCT07609108 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
Pancreatic Neuroendocrine Tumor (pNET), Extra-Pancreatic Neuroendocrine Tumor (epNET)
Exelixis · started 2025-07-21
Alabama · Arizona · California · District of Columbia · Florida · Kentucky · Louisiana · Massachusetts
NCT06943755 on ClinicalTrials.gov ↗
Active Phase 3
A Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated · started 2022-11-08
Alabama · Arizona · Arkansas · California · Colorado · Florida · Georgia · Idaho
NCT05444257 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
CR-001 in Adult Participants With Locally Advanced or Metastatic Solid Tumors
Locally Advanced / Metastatic Solid Tumors
Crescent Biopharma, Inc. · started 2026-02-17
Alabama · California · Colorado · District of Columbia · Florida · Michigan · New York · Ohio
NCT07335497 on ClinicalTrials.gov ↗
Active Phase 2
Efficacy and Safety of IMVT-1402 in Adult Participants With Primary Sjogren's Disease With Moderate to Severe Systemic Disease Activity
Primary Sjögren's Syndrome
Immunovant Sciences GmbH · started 2025-06-30
California · Colorado · Florida · Illinois · Louisiana · New York · Pennsylvania · Tennessee
NCT06979531 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study in Young People and Adults to Learn About the Medicine Ritlecitinib for Treatment of Patchy Hair Loss, Known by the Medical Term as Moderate Alopecia Areata
Alopecia Areata
Pfizer · started 2026-07-30
California · Florida · Illinois · Indiana · Iowa · Maryland · Michigan · North Carolina
NCT07733765 on ClinicalTrials.gov ↗
Recruiting
Pivotal Study of the SUpira System in Patients Undergoing High-Risk Percutaneous COronaRy InTervention (HRPCI)
Coronary Artery Disease, High Risk Percutaneous Coronary Intervention, Interventional Cardiology, Mechanical Circulatory Support
Supira Medical · started 2026-05-11
California · Georgia · Illinois · Michigan · Minnesota · Missouri · New York · Ohio
NCT07296744 on ClinicalTrials.gov ↗
Starting soon Phase 1
A Phase 1b Study to Assess the Safety and Tolerability of AB126 Neural Exosomes in Patients With Moderate to Severe Acute Ischemic Stroke
Acute Ischemic Stroke
Aruna Bio, Inc. · started 2026-10
Texas
NCT07813130 on ClinicalTrials.gov ↗
Active
Clinical Investigation of Eye C Better's Photobionic Intraocular Pressure Biomonitor Tonometer
Elevated Intraocular Pressure (IOP)
EyeCBetter Corporation · started 2026-08-31
California
NCT07762053 on ClinicalTrials.gov ↗
Recruiting Phase 3
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
Solid Tumors, Hematologic Malignancies
Merck Sharp & Dohme LLC · started 2018-08-21
Arizona · California · Colorado · Connecticut · District of Columbia · Florida · Georgia · Hawaii
NCT03486873 on ClinicalTrials.gov ↗
Recruiting
Post Approval Effectiveness and Durability Evaluation of the Altaviva™ Tibial Device
Urge Urinary Incontinence
MedtronicNeuro · started 2026-03-17
Alabama · Idaho · Missouri · North Carolina · Ohio · Pennsylvania · South Carolina · South Dakota
NCT07456865 on ClinicalTrials.gov ↗
Active Phase 3
Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency
Hormone-Sensitive Prostate Cancer
AstraZeneca · started 2020-07-13
Arizona · California · Colorado · Connecticut · Florida · Illinois · Maryland · Michigan
NCT04493853 on ClinicalTrials.gov ↗
Recruiting
Shoulder Innovations Clinical Data Registry
Shoulder Arthroplasty
Shoulder Innovations · started 2024-10-23
Alabama · California · Colorado · Florida · Georgia · Maryland · Massachusetts · Michigan
NCT06754150 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)
Non-small Cell Lung Cancer
Genentech, Inc. · started 2020-11-06
California · Colorado · Connecticut · District of Columbia · Florida · Illinois · Massachusetts · Michigan
NCT04302025 on ClinicalTrials.gov ↗
Recruiting Phase 3
Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis
Multiple Sclerosis, Relapsing-Remitting
Bristol-Myers Squibb · started 2025-04-08
California · Florida · Illinois · Kentucky · New Jersey · Ohio · Oregon · Texas
NCT06408259 on ClinicalTrials.gov ↗
Recruiting
The WiSE®-UP Study (The WiSE System Utilization & Performance Study)
Heart Failure
EBR Systems, Inc. · started 2025-11-03
Arizona · Arkansas · Florida · Michigan · Missouri · New York · Ohio · Pennsylvania
NCT07098858 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis
Multiple Sclerosis (MS) Primary Progressive
Zenas BioPharma (USA), LLC · started 2026-03-23
Arizona · California · Florida · Kansas · Missouri · New Jersey · North Carolina · Ohio
NCT07067463 on ClinicalTrials.gov ↗
Recruiting Phase 3
Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE)
Complex Regional Pain Syndrome Type I
Ambros Therapeutics, Inc. · started 2026-04-14
Arizona · Arkansas · California · District of Columbia · Florida · Georgia · Illinois · Kansas
NCT07210515 on ClinicalTrials.gov ↗
Recruiting
Smart Baby Monitor Effects on Infant Sleep and Parent Well-being
Infant Sleep Problem
Udisense DBA Nanit · started 2026-07-15
New York
NCT07812896 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Study of the Safety and Efficacy of Prime Editing (PM577) in Participants With Wilson Disease (WD)
Wilson Disease, Wilson's Disease, Wilsons Disease
Prime Medicine, Inc. · started 2026-09
Illinois · Texas
NCT07748403 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study Evaluating MDX2301 in Healthy Adults and Adults at Higher Risk for Severe COVID-19.
COVID -19, COVID-19 (Prevention)
ModeX Therapeutics, An OPKO Health Company · started 2026-03-24
Nevada · Texas
NCT07445971 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Study of ASP388B Given by Itself and With Standard Therapies in Participants With Solid Tumors
Locally Advanced or Metastatic Solid Tumors
Astellas Pharma Global Development, Inc. · started 2026-09-02
New York · Virginia
NCT07730021 on ClinicalTrials.gov ↗
Recruiting
MagDI U.S. Registry
Anastomosis, Surgical, Internal Hernia, Bowel Obstruction
GT Metabolic Solutions, Inc. · started 2025-03-28
California · Florida · Kentucky · Louisiana · North Carolina · Washington
NCT06928545 on ClinicalTrials.gov ↗
Active Phase 1/Phase 2
A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes
Type 1 Diabetes
Vertex Pharmaceuticals Incorporated · started 2023-05-16
Florida · Illinois · Massachusetts · Pennsylvania · Wisconsin
NCT05791201 on ClinicalTrials.gov ↗
Recruiting Phase 1
SKL35501 With SKL35502 Imaging in Adults With NTSR1 Positive Advanced Solid Tumors
Selected Advanced Solid Tumors, Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC), Biliary Tract Cancer (BTC)
SK Life Science, Inc. · started 2026-08-19
Maryland · Pennsylvania
NCT07812805 on ClinicalTrials.gov ↗
Active Phase 1
Dose Optimization and Expansion Study of DFV890 in Adult Patients With Myeloid Diseases
Myeloid Diseases
Novartis Pharmaceuticals · started 2023-05-08
California · Florida · Illinois · Maryland · Massachusetts · Minnesota · New York · Tennessee
NCT05552469 on ClinicalTrials.gov ↗
Active Phase 2
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Meropenem-Vaborbactam in Children With Complicated Urinary Tract Infection, Including Acute Pyelonephritis
Acute Pyelonephritis, Complicated Urinary Tract Infection
Rempex (a wholly owned subsidiary of Melinta Therapeutics, LLC) · started 2025-06-03
Arkansas · California · Nebraska · Ohio
NCT06672978 on ClinicalTrials.gov ↗
Starting soon
INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac Recovery
Heart Failure, Cardiogenic Shock, Reduced Ejection Fraction Heart Failure
Abiomed Inc. · started 2026-09-01
Florida · Indiana · Minnesota · Missouri · New Jersey · North Carolina · Pennsylvania · Tennessee
NCT06965504 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Study to Evaluate the Safety and Efficacy of MK-3120 in Participants With Advanced Solid Tumors (MK-3120-002)
Advanced Solid Tumors, Malignant Neoplasm
Merck Sharp & Dohme LLC · started 2025-03-25
Alabama · Florida · New Jersey · Texas · Virginia
NCT06818643 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS
Amyotrophic Lateral Sclerosis
Vector Y Therapeutics · started 2025-12-19
Arizona · California · Florida · Massachusetts · New York · Pennsylvania
NCT07287397 on ClinicalTrials.gov ↗
Recruiting Phase 2
Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)
Acute Respiratory Distress Syndrome, Infections
BioAegis Therapeutics Inc. · started 2024-10-03
California · Georgia · Illinois · Kentucky · Minnesota · Missouri · Nebraska · New York
NCT05947955 on ClinicalTrials.gov ↗
Recruiting
A Prospective Study to Develop and Clinically Validate an in Vitro Diagnostic Medical Device That Uses Blood to Classify Patients at High Risk for Breast Cancer
Breast Neoplasm
EXoPERT · started 2024-10-16
Hawaii
NCT06672302 on ClinicalTrials.gov ↗
Recruiting Phase 4
A Clinical Investigation of a Topical Moisturizer on Skin Barrier Function in Adults With Sensitive Skin
Sensitive Skin
Good Molecules, LLC · started 2026-09-14
New York
NCT07811531 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee
Chondral Defect, Osteochondritis Dissecans (OCD), Articular Cartilage Defect, Articular Cartilage Disorder of Knee
Vericel Corporation · started 2018-10-24
California · Louisiana · Maryland · Michigan · New York · Ohio · Pennsylvania · Texas
NCT03588975 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Randomized, Phase 2 Study of Oral BGE-102 in Participants With Center-Involved Diabetic Macular Edema
Diabetic Macular Edema (DME)
BioAge Labs, Inc. · started 2026-08-21
Texas
NCT07812090 on ClinicalTrials.gov ↗
Starting soon
Reduction of Anxiety Through Dual Treatment: Digital CBT & NBHWC Coaching - A Randomized Clinical Trial
Hearing Disability, Anxiety, Mobility Disability
Toivoa Inc · started 2026-09
Delaware · New Jersey · Ohio · Texas
NCT07140497 on ClinicalTrials.gov ↗
Active Phase 1/Phase 2
NG101 AAV Gene Therapy in Subjects With Wet Age-Related Macular Degeneration
Age-Related Macular Degeneration
Elisigen, Inc. · started 2023-09-08
Ohio
NCT05984927 on ClinicalTrials.gov ↗
Recruiting Phase 2
Prevention of Recurrent C. Difficile Infection Study With AZD5148 Monoclonal Antibody
Clostridioides Difficile Infection
AstraZeneca · started 2025-12-10
Arizona · California · Connecticut · Florida · Georgia · Idaho · Illinois · Kentucky
NCT07285213 on ClinicalTrials.gov ↗
Recruiting Phase 1
Ph 1a/1b Single Ascending Dose and Multiple Ascending Dose Study of ARQ-234
Atopic Dermatitis (AD), Eczema
Arcutis Biotherapeutics, Inc. · started 2026-03-02
Indiana · New Jersey · Texas · Utah
NCT07453602 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction
Heart Failure With Reduced Ejection Fraction
Novartis Pharmaceuticals · started 2026-03-18
Florida
NCT07465653 on ClinicalTrials.gov ↗
Recruiting Phase 4
A Study Evaluating the Effectiveness and Safety of Risdiplam Administered in Pediatric Patients With Spinal Muscular Atrophy Who Experienced a Plateau or Decline in Function After Gene Therapy
Muscular Atrophy, Spinal
Hoffmann-La Roche · started 2024-08-14
Arkansas · California · Colorado · Florida · Georgia · Michigan · Pennsylvania · Texas
NCT05861999 on ClinicalTrials.gov ↗
Active
Evaluation of the GORE® TBE Device in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta, Zone 2
Aortic Aneurysm, Thoracic, Aorta; Lesion
W.L.Gore & Associates · started 2016-09-06
California · Connecticut · District of Columbia · Florida · Georgia · Illinois · Indiana · Kentucky
NCT02777593 on ClinicalTrials.gov ↗
Active Phase 3
Placebo-controlled, Study of Concurrent Chemoradiation Therapy With Pembrolizumab Followed by Pembrolizumab and Olaparib in Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK 7339-013/KEYLYNK-013)
Small Cell Lung Cancer
Merck Sharp & Dohme LLC · started 2020-12-08
Arizona · California · District of Columbia · Florida · Illinois · Indiana · Kentucky · Louisiana
NCT04624204 on ClinicalTrials.gov ↗
Recruiting Phase 3
Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis
Knee Cartilage Defects
Medipost, Inc. · started 2026-03-11
Alabama · Arizona · California · Colorado · Kentucky · Louisiana · Michigan · Minnesota
NCT07339111 on ClinicalTrials.gov ↗
Recruiting Phase 2
Study of Patritumab Deruxtecan Plus Pembrolizumab With Other Anticancer Agents in Participants With High-Risk Early-Stage Triple-Negative or Hormone Receptor-Low Positive/HER-2 Negative Breast Cancer (MK-1022-010, HERTHENA-Breast-03)
Breast Neoplasms, Breast Cancer
Merck Sharp & Dohme LLC · started 2025-03-20
California · Illinois · Montana · Oregon · Tennessee · Texas · Virginia
NCT06797635 on ClinicalTrials.gov ↗
Recruiting Phase 3
STOP-HAE: A Phase 3 Study of ADX-324 in HAE
Hereditary Angioedema, HAE, Hereditary Angioedema - Type 1, Hereditary Angioedema - Type 2
ADARx Pharmaceuticals, Inc. · started 2025-08-28
Arizona · Arkansas · California · Colorado · Florida · Maryland · Michigan · Missouri
NCT06960213 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Evaluate Effect of AZD6234 as an Adjunct to Incretin-based Therapies in Adult Participants With Obesity or Overweight With Weight-related Comorbidity With or Without Type 2 Diabetes Mellitus
Obesity or Overweight, Weight-Related Comorbidity, With/Without Diabetes Mellitus, Type 2
AstraZeneca · started 2026-08-24
California · Florida · Georgia · Illinois · Maryland · Missouri · Nevada · New Jersey
NCT07776509 on ClinicalTrials.gov ↗
Recruiting Phase 2
Phase 2A/B Efficacy and Safety of Dabogratinib in Participants With Low Grade Upper Tract Urothelial Carcinoma
Low Grade Upper Tract Urothelial Carcinoma
Tyra Biosciences, Inc · started 2025-12-22
Florida · Georgia · Illinois · Indiana · Massachusetts · Michigan · Missouri · New Jersey
NCT07265947 on ClinicalTrials.gov ↗
Recruiting
Transverse Tibial Bone Transport (TTT) in the Management of Chronic Diabetic Lower Extremity Wounds
Diabetic Foot Ulcer, Chronic Ulcers of the Lower Limb
Biodynamik, Inc · started 2026-09-15
Florida
NCT07444593 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)
Esophageal Squamous Cell Carcinoma
Merck Sharp & Dohme LLC · started 2025-07-30
Pennsylvania
NCT06780111 on ClinicalTrials.gov ↗
Recruiting
Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study
ALS - Amyotrophic Lateral Sclerosis
PathMaker Neurosystems Inc. · started 2025-02-10
Massachusetts
NCT06649955 on ClinicalTrials.gov ↗
Active
Collection of Training Data for LuminX Probe AI Models
Data Collection for AI Training of Dental Prob
LuminX · started 2026-06-03
California · Florida · Tennessee
NCT07565480 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
FiH Study to Investigate Safety, PK and Efficacy of the NaPi2b ADC TUB-040 in Patients With PROC or r/r Adenocarcinoma NSCLC
Ovarian Cancer, Non-small Cell Lung Cancer
Tubulis GmbH · started 2024-06-12
Alabama · New Jersey · New York · Ohio · Oklahoma · Texas · Utah · Virginia
NCT06303505 on ClinicalTrials.gov ↗
Active Phase 1
A Safety Study of SEA-CD70 in Patients With Myeloid Malignancies
Myelodysplastic Syndrome, Acute Myeloid Leukemia
Seagen, a wholly owned subsidiary of Pfizer · started 2020-08-07
Alabama · California · Colorado · Kansas · Kentucky · Massachusetts · Michigan · Missouri
NCT04227847 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM
Weight Management
AstraZeneca · started 2026-06-29
Alabama · Arizona · Arkansas · California · Colorado · Connecticut · Florida · Georgia
NCT07667803 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
DOC1021 Dendritic Cell Immunotherapy for Refractory Melanoma
Refractory Melanoma
Diakonos Oncology Corporation · started 2026-04-06
Alabama · Arizona · California · Massachusetts · New Jersey · North Carolina · Texas
NCT07288112 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease
Sickle Cell Disease
Novartis Pharmaceuticals · started 2024-08-15
Alabama · Florida · Massachusetts · North Carolina · Pennsylvania · Rhode Island · Texas
NCT06546670 on ClinicalTrials.gov ↗
Active Phase 2
A Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7204239 in Combination With Tirzepatide in Participants With Obesity or Overweight With At Least One Weight-related Comorbidity
Obesity, Overweight, Overweight With One Weight Related Comorbidity
Hoffmann-La Roche · started 2025-05-05
Alabama · California · Florida · Georgia · Illinois · New York · North Carolina · Ohio
NCT06965413 on ClinicalTrials.gov ↗
Active
A Prospective Imaging Study of the Integrated TrueBeam-HyperSight CBCT System
Head and Neck Cancer, Thoracic Cancer, Abdominal Cancer, Pelvic Cancer
Varian, a Siemens Healthineers Company · started 2023-08-29
Ohio
NCT05975619 on ClinicalTrials.gov ↗
Active Phase 2/Phase 3
A Study to Determine the Efficacy and Safety of Tividenofusp Alfa (DNL310) vs Idursulfase in Pediatric and Young Adult Participants With Neuronopathic (nMPS II) or Non-Neuronopathic Mucopolysaccharidosis Type II (nnMPS II)
Mucopolysaccharidosis II
Denali Therapeutics Inc. · started 2022-07-21
California · Illinois · New Jersey · North Carolina · Ohio · Pennsylvania · Texas · Utah
NCT05371613 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Research Study Investigating How a New Medicine NNC0113-5840 Works in People With Overweight or Obesity
Obesity, Overweight
Novo Nordisk A/S · started 2026-05-01
California · Maryland
NCT07566390 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Evaluate the Safety and Effectiveness of Upadacitinib in Pediatric Participants With Alopecia Areata
Severe Alopecia Areata
AbbVie · started 2026-08-24
California · Florida · Idaho · Indiana · Nebraska · Texas
NCT07772492 on ClinicalTrials.gov ↗
Recruiting
EVERO Drug-coated Balloon (DCB) Randomized Trial
Peripheral Vascular Disease, Peripheral Arterial Disease
Cook Research Incorporated · started 2026-04-17
Connecticut · Florida · Iowa · Michigan · Mississippi · South Carolina · Texas
NCT07144150 on ClinicalTrials.gov ↗
Recruiting Phase 2
An Open-Label Pilot Study of VTX2735 in Recurrent Pericarditis
Recurrent Pericarditis
Zomagen Biosciences Ltd. · started 2025-01-28
Arizona · California · Florida · Illinois · Kentucky · Massachusetts · Minnesota · New York
NCT06836232 on ClinicalTrials.gov ↗
Recruiting Phase 1
Determine Maximum Tolerated Dose, Safety, and Tolerability of Rhenium (186Re) in Pediatric Recurrent, Refractory or Progressive Ependymoma and High-Grade Glioma
Ependymoma, High Grade Gliomas
Cerenome · started 2026-08-01
Illinois
NCT07061626 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in Children and Adolescents With Type 2 Diabetes
Diabetes Mellitus, Type 2
Novo Nordisk A/S · started 2026-08-04
Connecticut · Florida · Georgia · Illinois · Indiana · Iowa · Michigan · New York
NCT07282613 on ClinicalTrials.gov ↗
Active Phase 3
Assessment of Efficacy and Safety of Monalizumab Plus Cetuximab Compared to Placebo Plus Cetuximab in Recurrent or Metastatic Head and Neck Cancer
Squamous Cell Carcinoma of the Head and Neck
AstraZeneca · started 2020-10-02
Arizona · Illinois · Kansas · Massachusetts · Michigan · Minnesota · Missouri · Nevada
NCT04590963 on ClinicalTrials.gov ↗
Recruiting Phase 3
Two Arm, Double-blind, Phase III Study Assessing Efficacy and Safety of Ianalumab Versus Placebo, in Participants With Sjögren's Disease With High Symptom Burden
Sjögren´s Disease
Novartis Pharmaceuticals · started 2026-07-16
Arizona · Florida · Illinois · Michigan · North Carolina · Oklahoma · Tennessee · Texas
NCT07621809 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Eptinezumab in Pediatric Participants With Episodic Migraine
Episodic Migraine
H. Lundbeck A/S · started 2023-06-08
Connecticut · Florida · Georgia · Kentucky · Maryland · Michigan · New York · North Carolina
NCT05897320 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Gammagard Liquid (Immune Globulin Infusion, 10%) to Prevent Infections in Adults With Multiple Myeloma
Multiple Myeloma, Secondary Immunodeficiency
Takeda · started 2026-01-14
Alabama · California · Kansas · Maryland · Michigan · Missouri · New York
NCT06980480 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study to Evaluate Sequential Administration of Injections of AGN-151586 Followed by BOTOX in Adult Participants for Treatment of Glabellar Lines
Glabellar Lines
AbbVie · started 2026-08-10
Arizona · California · Louisiana · Massachusetts · North Carolina · Tennessee · Texas
NCT07756580 on ClinicalTrials.gov ↗
Recruiting Phase 3
Study to Assess the Efficacy, Pharmacokinetics, Safety and Tolerability of Iptacopan in Pediatric Patients With Primary IgAN
Primary Immunoglobulin A Nephropathy (IgAN)
Novartis Pharmaceuticals · started 2025-11-27
California · Colorado · Florida · Pennsylvania · Utah
NCT06994845 on ClinicalTrials.gov ↗
Active
Polycystic Kidney Disease 1 (PKD1) Gene Variant Groups in Autosomal Dominant Polycystic Kidney Disease
Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Vertex Pharmaceuticals Incorporated · started 2024-12-19
Alabama · California · Connecticut · Florida · Georgia · Illinois · Iowa · Kansas
NCT06747572 on ClinicalTrials.gov ↗
Recruiting
Assessing Connected-Health, Pressure-Monitoring Technology for Improving Compression Therapy in Venous Leg Ulcer Treatment
Venous Leg Ulcers (VLUs)
Feeltect Limited · started 2025-11-06
Indiana
NCT07152717 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Phase I Study to Investigate the Pharmacokinetics and Safety of Capivasertib in Participants With Moderate Hepatic Impairment
Moderate Hepatic Impairment
AstraZeneca · started 2026-01-06
California · Texas
NCT07343960 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062)
Human Immunodeficiency Virus Type 1 (HIV-1) Infection
Merck Sharp & Dohme LLC · started 2025-12-18
California · Colorado · District of Columbia · Florida · Georgia · Illinois · Michigan · Missouri
NCT07266831 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Assess the Tolerability of Ianalumab (VAY736) With Investigator's Choice Thrombopoietin Receptor Agonist (IC TPO-RA) in Patients With Primary Immune Thrombocytopenia (ITP)
Primary Immune Thrombocytopenia (ITP), Primary Evans Syndrome (ES)
Novartis Pharmaceuticals · started 2026-08-04
Arkansas · Connecticut · Florida · Illinois · Louisiana · Minnesota · Montana · New Jersey
NCT07421167 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Long-Term Study of Zasocitinib in Children and Teenagers With Plaque Psoriasis
Plaque Psoriasis
Takeda · started 2025-12-04
California · Florida · Illinois · Ohio · South Carolina · Texas · Wisconsin
NCT07250802 on ClinicalTrials.gov ↗
Recruiting
OverTTuRe: Characteristics, Treatment Patterns and Outcomes of Patients With ATTR Amyloidosis
ATTR Amyloidosis
AstraZeneca · started 2023-08-21
Minnesota
NCT06355934 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study to Assess the Safety and Clinical Activity of Azer-cel in Participants With B-cell Mediated Autoimmune Disorders
B-cell Mediated Autoimmune Disorders
TG Therapeutics, Inc. · started 2025-05-06
California · Michigan · Nebraska · New York · Ohio · Wisconsin
NCT06680037 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Investigate Efficacy and Safety of Teplizumab Compared With Placebo in Participants 1 to 25 Years of Age With Stage 3 Type 1 Diabetes
Type 1 Diabetes Mellitus
Sanofi · started 2025-08-06
Arizona · California · Colorado · Connecticut · Florida · Georgia · Idaho · Kentucky
NCT07088068 on ClinicalTrials.gov ↗
By invitation Phase 3
Long-Term Extension Study of Vosoritide to Treat Children With Hypochondroplasia
Hypochondroplasia
BioMarin Pharmaceutical · started 2025-06-20
Arizona · California · Delaware · District of Columbia · Illinois · Maryland · Minnesota · Missouri
NCT07073014 on ClinicalTrials.gov ↗
Recruiting Phase 2
Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities
Obesity, Overweight
AbbVie · started 2026-08-04
Alabama · Arizona · California · Florida · Idaho · Kentucky · Missouri · North Carolina
NCT07752979 on ClinicalTrials.gov ↗
Recruiting Phase 1
M0324 as Monotherapy and in Combination With Pembrolizumab or Chemotherapy in Participants With Selected Advanced Solid Tumors
Advanced Solid Tumor
EMD Serono Research & Development Institute, Inc. · started 2025-10-10
Connecticut · New York · Texas
NCT07166601 on ClinicalTrials.gov ↗
Recruiting
Fainting Detection And Early Warning In Syncope Evaluation Study (ARISE)
Orthostatic Hypotension, Reflex Syncope
Boston Scientific Corporation · started 2026-08-06
Minnesota
NCT07502599 on ClinicalTrials.gov ↗
Active Phase 3
A Study of Osimertinib With or Without Chemotherapy Versus Chemotherapy Alone as Neoadjuvant Therapy for Patients With EGFRm Positive Resectable Non-Small Cell Lung Cancer
Non-Small Cell Lung Cancer
AstraZeneca · started 2020-12-16
California · Massachusetts · New Hampshire · New York · Texas · Virginia · Washington
NCT04351555 on ClinicalTrials.gov ↗
By invitation Phase 3
A Study to Evaluate the Long-term Safety, Tolerability, and Efficacy of Subcutaneous Sonelokimab in Participants With Psoriatic Arthritis
Arthritis, Psoriatic
MoonLake Immunotherapeutics AG · started 2025-11-13
Arizona · Arkansas · California · Florida · North Carolina · Ohio · Pennsylvania · Tennessee
NCT07223138 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Phase 2a/b Study to Assess the Efficacy, Safety and Tolerability of DDY391 in Participants With Sjögren's Disease
Sjögren's Disease
Novartis Pharmaceuticals · started 2026-08-24
Florida · Oklahoma · Texas
NCT07737743 on ClinicalTrials.gov ↗
Recruiting Phase 2
Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)
Type 2 Diabetes, Cortisol Excess
Sparrow Pharmaceuticals · started 2025-11-29
Arizona · California · Florida · Georgia · Idaho · Illinois · Iowa · Kansas
NCT07296484 on ClinicalTrials.gov ↗
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Priya Life Science (2026). Clinical Trials in the USA Tracker. Available at: https://priyalifescience.com/clinical-trials-usa (Accessed: 11 September 2026).

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Source: ClinicalTrials.gov, U.S. National Library of Medicine — industry-sponsored studies in a recruiting status with at least one US site, most recently updated first, refreshed daily. This is a curated slice of the full registry, not every US trial. Listing here is informational and not medical advice; eligibility is determined by each study team. Patients should discuss participation with their clinician. Compare pay for the teams running these studies in our US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish and EU sites, see our Ireland and EU trackers.