Clinical trial register · United States · industry-sponsored

Clinical Trials in the USA: Industry-Sponsored Studies

Every industry-sponsored study on the ClinicalTrials.gov registry that lists a US site and is open, about to open, active-but-closed, or enrolling by invitation. This deliberately excludes academic and other non-industry sponsors — the full US registry across all sponsors runs to over 22,000 recruiting studies alone.

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Source: ClinicalTrials.gov. Complete coverage of the industry-sponsored slice — all 9120 matching records are in this view (non-industry sponsors are out of scope by design, not truncated). Synced 07 Nov 2026, 03:16 UTC

9120

Studies in scope

industry-sponsored, all four open statuses

4955

Recruiting now

open to new participants

2174

Lead sponsors

across recruiting studies

Top states

California 5303 Florida 4471 Illinois 2484 Georgia 2362 Arizona 2258

Trials in this register

Status

Study

Lead sponsor

Phase

Enrol

US states

Start

Recruiting

Efficacy and Safety Study to Evaluate SD-101 in Epidermolysis Bullosa

NCT07482787Epidermolysis Bullosa (EB)

Paradigm Therapeutics

Phase 3

California, Pennsylvania, South Carolina

2026-07-21

Recruiting

Study of RGT-490 in Patients With PIK3CA-Mutated Advanced Solid Tumors

NCT07524322Breast Cancer, Ovarian Cancer, Endometrial Cancer, PIK3CA Mutation

Regor Pharmaceuticals Inc.

Phase 1

California, Pennsylvania, Texas, Virginia

2026-07-21

Recruiting

A Study to Evaluate the Efficacy and Safety of Once Daily Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Arterial Hypertension (PAH)

NCT07481981Pulmonary Arterial Hypertension

DrugTreprostinil Palmitil

Insmed Incorporated

Phase 3

344

California, Kansas, Nebraska, New York, Pennsylvania, South Carolina

2026-07-21

Recruiting

DReAMzz- Dronabinol and Acetazolamide Medication for Sleep Apnea (ZZ). Dose Confirmation Crossover Study for IHL-42X in Subjects With Obstructive Sleep Apnea.

NCT07635563Obstructive Sleep Apnea (OSA)

DrugAcetazolamide

Incannex Healthcare Ltd

Phase 2

120

California, Florida, Louisiana, Maryland, Ohio, South Carolina, Tennessee, Texas

2026-07-21

Recruiting

A Study to Learn More About the Safety of a Single Dose of BIIB144 and How it is Processed in the Body of Healthy Adult Participants Ages 18 to 55 Years Old as Compared to a Placebo

NCT07662148Healthy Volunteer

Biogen

Phase 1

Nevada

2026-07-21

By invitation

ProNephro NGAL Test for Early Detection of Acute Kidney Injury in Adult ICU Patients (ALPACA)

NCT07751913Acute Kidney Injury

BioPorto Diagnostics

Observational

800

Alabama, Connecticut, Massachusetts, New Mexico

2026-07-21

Recruiting

A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Inebilizumab in Children With Generalized Myasthenia Gravis (gMG)

NCT06987539Generalized Myasthenia Gravis

DrugInebilizumab

Amgen

Phase 2

Illinois, Pennsylvania, Texas, Washington

2026-07-21

Recruiting

A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease (SCD)

NCT07656415Sickle Cell Disease

DrugMitapivat

Agios Pharmaceuticals, Inc.

Phase 3

159

Indiana, Michigan, Mississippi, New York, Texas

2026-07-21

Recruiting

SLC6A1-NDD Prospective Longitudinal Natural History Study

NCT07531511SLC6A1 Neurodevelopmental Disorder (NDD), Developmental and Epileptic Encephalopathies (DEE)

UCB Biopharma SRL

Observational

New York

2026-07-21

Recruiting

A Study to Find Out How Nerandomilast is Tolerated, Handled by the Body, and if it Helps Children and Adolescents With Interstitial Lung Disease (FIBRONEER-chILD)

NCT07366034Fibrosing Interstitial Lung Disease

DrugNerandomilast

Boehringer Ingelheim

Phase 3

California, Colorado, Maryland, Massachusetts, Minnesota, Ohio, Pennsylvania

2026-07-21

Recruiting

Data Collection Study Using CS (CardiacSense) BP (Blood Pressure) Watch and Pillow Systems

NCT07749963Blood Pressure Monitoring

CardiacSense Ltd.

Not applicable

100

Colorado

2026-07-21

Recruiting

Obtaining Descriptive Classifications of Pruritus and Assessing Change in Pruritus Over Time in Atopic Dermatitis Patients Using Topical Roflumilast Cream.

NCT07560618ITCH, Atopic Dermatitis

DrugRoflumilast

Integrative Skin Science and Research

Phase 4

California

2026-07-21

Recruiting

A US Study That Observes How Parkinson's Disease Changes Over Time in Patients Who Still Have Movement Symptoms Despite Taking Parkinson's Medications

NCT07330258Parkinson's Disease

Bayer

Observational

300

Arizona, California, Connecticut, Florida, Georgia, Illinois, Maryland, Massachusetts

2026-07-21

Not yet open

Evaluation of SofWave Sofware-Guided Energy Delivery for Lower Face and Neck Rejuvenation

NCT07723664Facial Wrinkles, Jawline Contour, Skin Laxity

Sofwave Medical LTD

Not applicable

Texas

2026-07-20

Recruiting

A Study of MX006 in Patients With Advanced and/or Metastatic Tumors Known to Express B7-H3

NCT07807241Advanced and/or Metastatic Solid Tumors Known to Express B7-H3

Myricx Pharma Limited

Phase 1

120

Florida, Georgia, Maryland, Texas, Virginia

2026-07-20

Active, closed

A Study of LY4268989 (MORF 057) in Healthy Participants

NCT07707375Healthy

DrugZotemtegrast

Eli Lilly and Company

Phase 1

Florida

2026-07-20

Recruiting

Acquisition and Clinical Image Evaluation of Fujifilm's High Resolution (HR) Digital Breast Tomosynthesis (DBT) Images.

NCT07471750Routine Screening Mammography

Fujifilm Medical Systems USA, Inc.

Not applicable

Utah

2026-07-20

Recruiting

VIATORR® TIPS Study Evaluating 6-10mm Diameters (VIATIPS)

NCT07390344Ascites, Variceal Bleeding, Portal Hypertension Related to Cirrhosis

W.L.Gore & Associates

Observational

152

Georgia, Minnesota, Ohio

2026-07-20

Active, closed

A Study to Learn About COVID-19 Antivirals in People With SARS-CoV-2 Infection From 2023-2026

NCT07900139COVID-19 SARS-CoV-2 Infection

Pfizer

Observational

New York

2026-07-20

Recruiting

An Open-Label Extension Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

NCT07234032Pulmonary Hypertension, Interstitial Lung Disease

DrugTreprostinil Palmitil

Insmed Incorporated

Phase 3

344

Florida, Oregon

2026-07-20

Active, closed

A Study of Eloralintide (LY3841136) in Healthy Participants

NCT07701083Healthy Volunteers

DrugEloralintide

Eli Lilly and Company

Phase 1

Florida, Texas

2026-07-20

Recruiting

REGN15505 (PSMAx4-1BB) Alone or in Combination With Cemiplimab or REGN4336 (PSMAxCD3) in Adult Patients With Metastatic Castration-Resistant Prostate Cancer and Clear Cell Renal Cell Carcinoma

NCT07594106Metastatic Castration-Resistant Prostate Cancer (mCRPC), Clear Cell Renal Cell Carcinoma (ccRCC)

DrugsREGN4336·Cemiplimab

Regeneron Pharmaceuticals

Phase 1/2

265

Arizona, California, Florida, Illinois, Missouri, Texas

2026-07-20

By invitation

Study to Evaluate the Efficacy and Safety of Lerodalcibep in Children 6 to 17 Years, With Heterozygous FH

NCT07102511Familial Hypercholesterolemia - Heterozygous

DrugLerodalcibep

LIB Therapeutics LLC

Phase 3

150

Ohio

2026-07-20

Recruiting

DBC-664 in Adult Patients With Solid Tumors

NCT07705035Malignant Germ Cell Tumor, Lung Adenocarcinoma, Gastric/Esophageal/Gastroesophageal Junction (GEJ) Adenocarcinoma, Urothelial Carcinoma

Duboce Biopharmaceuticals, Inc.

Phase 1

210

Colorado, Michigan, Missouri, New Jersey, New York, Tennessee, Texas

2026-07-17

Recruiting

A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)

NCT07654374Obesity, Overweight, Chronic Weight Management, Type2 Diabetes Mellitus

DrugAleniglipron

Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics

Phase 3

1,100

Alabama, Arizona, Arkansas, California, Connecticut, Florida, Georgia, Idaho

2026-07-17

Recruiting

Post-Marketing Study for Early-Stage Low-Risk Breast Cancer Treatment Using ProSense® Cryoablation (ChoICE Trial)

NCT07629206Low-Risk, Early Stage Breast Cancer

IceCure Medical Ltd.

Not applicable

400

California, Oregon, Tennessee

2026-07-17

Active, closed

A Comparative Study to Investigate the Difference in Blood Levels of Two Different Formulations of GSK5784283

NCT07712393Asthma

DrugGSK5784283

GlaxoSmithKline

Phase 1

Texas

2026-07-17

Recruiting

Safety and Preliminary Efficacy of CTX112 in Adult Participants With Relapsed/Refractory Hematologic Autoimmune Disease

NCT07549698Warm Autoimmune Hemolytic Anemia (WAIHA), ITP - Immune Thrombocytopenia, Warm Autoimmune Hemolytic Anemia, Immune Thrombocytopenic Purpura

DrugZugo-cel

CRISPR Therapeutics AG

Phase 1/2

Massachusetts, Minnesota, Nebraska

2026-07-17

Recruiting

A Study of the Preliminary Efficacy of DARE-HPV to Treat High-risk Persistent Human Papillomavirus (hrHPV)

NCT07601074Human Papilloma Virus (HPV), High-risk Human Papillomavirus Infection

DrugLopinavir / Ritonavir

Daré Bioscience, Inc.

Phase 2

118

Alabama, Arizona, Arkansas, Minnesota, Nebraska, Ohio, Texas, Utah

2026-07-17

Recruiting

A Trial to Examine if Repinatrabit is Processed Differently in Adults With Reduced Liver or Kidney Function Compared to Adults With Normal Liver and Kidney Function

NCT07713758Phenylketonuria

DrugRepinatrabit

Otsuka Pharmaceutical Development & Commercialization, Inc.

Phase 1

Florida

2026-07-17

Recruiting

A Study to Evaluate the Safety and Antitumor Activity of GS-1206 in Adults With Solid Tumors

NCT07703878Solid Tumor

Gilead Sciences

Phase 1

302

Michigan, Texas

2026-07-17

By invitation

Real-World Use of an iPad-Based Light Therapy App, With Optional Biomarker Collection

NCT07744711Circadian Rhythms

Circadian OS, Inc

Not applicable

New York

2026-07-17

Recruiting

A Study of LY4178256 in Healthy Participants

NCT07698210Healthy Volunteers

Eli Lilly and Company

Phase 1

California, Utah

2026-07-16

Recruiting

Phase 1/2 Study of BHB810 in Advanced Gastric and GEJ Adenocarcinoma

NCT07529808Gastric Cancer, Gastric Adenocarcinoma, Gastric (Stomach) Cancer, Gastroesophageal Adenocarcinoma

BigHat Biosciences, Inc.

Phase 1/2

164

California, Virginia

2026-07-16

Recruiting

An Observational Study to Learn More About How Well Damoctocog Alfa Pegol Works in Previously Treated Children With Hemophilia A

NCT07088458Hemophilia A

DrugDamoctocog alfa pegol

Bayer

Observational

California, New Jersey

2026-07-16

Recruiting

A Study of JZP3507 (ONC206) in Recurrent Grade 2 or 3 Meningioma

NCT07533942Meningioma

DrugONC206

Jazz Pharmaceuticals

Phase 2

California, Connecticut, Indiana, Louisiana, Massachusetts, New York, North Carolina, Utah

2026-07-16

Recruiting

An Open-label Study to Investigate the Efficacy and Safety of Dato-DXd + Rilvegostomig vs SoC in Adult Participants With High-risk MIUC

NCT07720284High-risk Muscle Invasive Urothelial Carcinoma

DrugsRilvegostomig·Enfortumab Vedotin·Dato-DXd·Opdivo

AstraZeneca

Phase 3

915

Arkansas, California, Illinois, Massachusetts, Missouri, Nebraska, New York, Ohio

2026-07-16

Recruiting

A Single-Dose Study of MT-201 and Concomitant Infliximab in Healthy Participants

NCT07776782Healthy Volunteer

DrugMT-201

Mirador Therapeutics, Inc.

Phase 1

California

2026-07-16

Recruiting

Two Arm, Double-blind, Phase III Study Assessing Efficacy and Safety of Ianalumab Versus Placebo, in Participants With Sjögren's Disease With High Symptom Burden

NCT07621809Sjögren´s Disease

DrugIanalumab

Novartis Pharmaceuticals

Phase 3

570

Arizona, Florida, Illinois, Massachusetts, Michigan, New Jersey, New York, North Carolina

2026-07-16

Not yet open

MT-601 Administered To Patients With Locally Advanced Unresectable or Metastatic Pancreatic Cancer

NCT06549751Pancreas Cancer, Pancreatic Cancer Metastatic, Pancreatic Cancer (Unresectable)

Marker Therapeutics, Inc.

Phase 1

Texas

2026-07-16

Recruiting

A Phase 1 and 2 Study of VMD-102 in Hepatocellular Carcinoma and Other Solid Tumors

NCT07636785Hepatocellular Carcinoma (HCC), Metastatic Uveal Melanoma, Renal Cell Carcinoma (RCC), Nonsmall Cell Lung Cancer

VM Discovery, Inc.

Phase 1/2

111

Arizona, California

2026-07-16

Recruiting

A Clinical Study to Evaluate the Efficacy and Safety of Frevecitinib (KN-002) in Patients With Severe Asthma

NCT07532265Severe Asthma

Kinaset Therapeutics Inc

Phase 2

512

California, Florida, Illinois, Missouri, North Carolina, Pennsylvania, South Carolina, Texas

2026-07-16

Recruiting

Smart Baby Monitor Effects on Infant Sleep and Parent Well-being

NCT07812896Infant Sleep Problem

Udisense DBA Nanit

Not applicable

200

New York

2026-07-15

Recruiting

Pivotal Trial to Evaluate TraNsvenous TrIcuspid Valve ReplacemenT With LuX-Valve Plus System (The TRINITY Pivotal Trial)

NCT07454980Tricuspid Regurgitation (TR)

Jenscare Innovation Inc.

Not applicable

680

Florida, New York

2026-07-15

Recruiting

A Research Study on How UBT251 Affects Levels of Midazolam, Caffeine and Warfarin in the Blood of Participants With Excess Body Weight

NCT07710768Obesity, Overweight

DrugUBT251

Novo Nordisk A/S

Phase 1

California

2026-07-15

Recruiting

Adult Outpatient Linvoseltamab With Tocilizumab Prophylaxis to Mitigate the Risk of Cytokine Release Syndrome (CRS)

NCT07609940Relapsed/Refractory Multiple Myeloma (RRMM)

DrugsLinvoseltamab·Tocilizumab

Regeneron Pharmaceuticals

Phase 4

California, Florida, Louisiana, Maryland, Nevada, Texas, Washington

2026-07-15

By invitation

NeuroFinance Human Stress Trial During Financial and Informational Volatility

NCT07622589Psychological Stress, Anxiety, Emotional Stress, Autonomic Nervous System Dysfunction

Truway Health, Inc.

Observational

2,500

New York

2026-07-15

Not yet open

Light Utilization COX-Inhibitory Device Therapy for Infant Cardiac Arrest (LUTICA Study). The LUCID Device is Used in the Treatment of Ischemic Brain Reperfusion Injury Caused by Cardiac Arrest in Pediatric Patients.

NCT07556939Reperfusion Injury, Post Cardiac Arrest Brain Injury

Mitovation, Inc

Not applicable

Michigan

2026-07-15

Recruiting

A Trial of CRD-4730 in HFrEF

NCT07750873Heart Failure With Reduced Ejection Fraction (HFrEF)

DrugCRD-4730

Cardurion Pharmaceuticals, Inc.

Phase 2

525

California, Michigan

2026-07-15

Recruiting

Dozee Validation for Contactless Heart Rate and Respiration Monitoring in Clinical Settings

NCT07735403No Specific Medical Conditions or Disease States

Turtle Shell Technologies Pvt. Ltd.

Observational

Texas

2026-07-15

Recruiting

Phase 1a/b Tolerability of NTR-1011 in Healthy Adults and Adult Patients With SLE and RA

NCT07237659SLE (Systemic Lupus), RA - Rheumatoid Arthritis

Neutrolis

Phase 1

California

2026-07-15

Not yet open

A Multi-Center, Individually-Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Superiority Trial to Evaluate the Efficacy of the Combination of Maraviroc and Atorvastatin for the Treatment of Subjects With Long COVID

NCT06974084Long COVID

DrugsMaraviroc·Atorvastatin

HealthBio, Inc.

Phase 2/3

252

Arizona

2026-07-15

Recruiting

A Phase 3 Study of Fenfluramine Hydrochloride in Rett Syndrome

NCT07503444Rett Syndrome

DrugFintepla

UCB BIOSCIENCES, Inc.

Phase 3

200

Arkansas, Florida, Georgia, Pennsylvania, Texas, Washington

2026-07-14

Recruiting

HB-adMSCs for the Treatment of Crohn's Disease

NCT07077746Crohn Disease (CD)

Hope Biosciences Research Foundation

Phase 2

Texas

2026-07-14

Recruiting

Study of Lenacapavir, Teropavimab, and Zinlirvimab Versus Cabotegravir and Rilpivirine in Virologically Suppressed Adults With HIV-1 on Oral Daily Antiretroviral Therapy

NCT07682961HIV Infections

DrugsTeropavimab·Zinlirvimab·Rilpivirine·Cabotegravir

Gilead Sciences

Phase 3

590

California, Florida, Georgia, Michigan, Missouri, Texas, Virginia, Washington

2026-07-14

Recruiting

Phase 1 Study of a Self-amplifying RNA Vaccine (ITI-5000) in Stage 2-3 Triple Negative Breast Cancer

NCT07652242Triple Negative Breast Cancer (TNBC)

DrugsOlaparib·Capecitabine·Pembrolizumab

Immunomic Therapeutics, Inc.

Phase 1

Michigan, Tennessee

2026-07-14

Recruiting

Study of Lenacapavir, Teropavimab, and Zinlirvimab in Virologically Suppressed Adults With HIV-1 on Stable Oral Treatment Regimens

NCT07683000HIV-1-infection

DrugsTeropavimab·Zinlirvimab·Lenacapavir

Gilead Sciences

Phase 3

590

Michigan, Virginia

2026-07-14

Active, closed

Study to Assess How Different Oral Formulations of Ubrogepant Move Through the Body in Healthy Adult Participants

NCT07680686Healthy Volunteer

DrugUbrogepant

AbbVie

Phase 1

Illinois

2026-07-14

Recruiting

An Early Prospective Study of the Traq™ Device for Characterization of Binocular Ocular Function in Normal Subjects and Subjects With Recent Traumatic Brain Injury

NCT07742878Mild Traumatic Brain Injury, Concussion, Binocular Visual Function, Neuro-Ophthalmology, Saccadic Eye Movements

Rebiscan, Inc.

Observational

Iowa

2026-07-14

Recruiting

A Study to Evaluate the Pharmacokinetics (PK) and Safety of a Single Dose of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Normal Hepatic Function and Participants With Hepatic Impairment

NCT07643155Hepatic Impairment

DrugTreprostinil Palmitil

Insmed Incorporated

Phase 1

California, Florida, Texas

2026-07-14

Recruiting

Neonatal Neurological Observation With Video AI

NCT07628829Neonatal Encephalopathy, Hypoxic-Ischemic Encephalopathy, Sedation, Sleep

Artemis AI Labs

Observational

200

New York

2026-07-13

Recruiting

REal-world Clinical evAulation of Medtronic NeurOVascular Products for Acute Ischemic Stroke (RECANOVA Registry)

NCT07599904Acute Ischemic Stroke

Medtronic Neurovascular Clinical Affairs

Observational

1,500

Michigan, New York, Texas

2026-07-13

Recruiting

Single and Multiple Dose Study to Evaluate Safety and Pharmacokinetics of BMS-986533 in Healthy Participants and Assessments of Food and pH Effects on Relative Bioavailability, and Drug-Drug Interaction Potential in Healthy Participants

NCT07629999Healthy Volunteers

DrugsDabigatran Etexilate·Famotidine·Rosuvastatin

Bristol-Myers Squibb

Phase 1

136

Nebraska

2026-07-13

Recruiting

Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1)

NCT07654361Obesity, Overweight, Chronic Weight Management

DrugAleniglipron

Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics

Phase 3

3,600

Alabama, Arizona, California, Florida, Georgia, Hawaii, Idaho, Illinois

2026-07-13

Recruiting

Pharmacokinetics, Safety and Efficacy of Nemolizumab in Participants Aged 6 to 23 Months With Moderate-to Severe Atopic Dermatitis

NCT07660835Moderate-to-Severe Atopic Dermatitis

DrugNemolizumab

Galderma R&D

Phase 2

Texas

2026-07-13

Recruiting

Mako-MORE Registry

NCT07647354Arthropathy of Knee, Arthropathy of Hip

Stryker Orthopaedics

Observational

950

Florida, Kentucky, New York, Ohio, Rhode Island

2026-07-13

Recruiting

Singula Phase 0.1 Primary Care Pilot

NCT07834684Depression - Major Depressive Disorder, Anxiety

Singula Health, Inc.

Observational

100

New York

2026-07-13

Active, closed

A Phase 1a/1b Study to Investigate the Safety, Tolerability, Microbiological Response, and Pharmacokinetics of Inhaled Rev-56 in Adult Healthy Volunteers and Adult Non-cystic Fibrosis Bronchiectasis (NCFB) Patients With Chronic P. Aeruginosa

NCT07709494Healthy Participants, Non-cystic Fibrosis Bronchiectasis

Revagenix, Inc.

Phase 1

Florida

2026-07-13

Not yet open

A Phase II Study of H021 Enteric-coated Tablets for Moderately to Severely Active Crohn's Disease

NCT07677514Crohn's Disease

Jiangsu Carephar Pharmaceutical Co., Ltd.

Phase 2

156

Connecticut, Florida

2026-07-12

Recruiting

Reducing Adverse Vascular Outcomes With Factor XI Inhibition in Adult Participants With Peripheral Artery Disease

NCT07318610Peripheral Artery Disease (PAD)

DrugsAmrecibart·Cenvacibart·Rivaroxaban

Regeneron Pharmaceuticals

Phase 3

7,050

Alabama, Arizona, Arkansas, California, Florida, Indiana, Louisiana, Mississippi

2026-07-10

Recruiting

An Extension Study to Assess Safety and Efficacy of Remibrutinib in Participants With Moderate to Severe HS

NCT07665437Hidradenitis Suppurativa

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

710

Alabama, Arkansas, California, Florida, Illinois, Indiana, Nebraska, New York

2026-07-10

Not yet open

Pilot Usability Study to Set Up and Use the Feetsee™ Foot Monitoring Device in Adults With Diabetes

NCT07666087Diabetes

Diabetis JSC

Observational

Texas

2026-07-10

Recruiting

ADAPT Forward 2 - ISA2 - a Study to Evaluate the Safety, Tolerability and Efficacy of Empasiprubart IV Monotherapy in Participants With AChR-Ab Seropositive Generalized Myasthenia Gravis

NCT07673627AChR-Ab Seropositive Generalized Myasthenia Gravis, Myasthenia Gravis (MG), MG - Myasthenia Gravis, gMG

DrugEmpasiprubart

argenx

Phase 2

California, Florida, Nevada, New York, Tennessee, Texas

2026-07-10

Recruiting

A Study to Investigate ANS02 in Participants With EGFR Mutation-Positive Non-Small Cell Lung Cancer

NCT07538804Non-Small Cell Lung Cancer

Avistone Biotechnology Co., Ltd.

Phase 1/2

294

Virginia

2026-07-10

Recruiting

DAREON®-NEC-1: A Study in People With Advanced Extrapulmonary Neuroendocrine Cancer (epNEC) to Compare Obrixtamig Plus Carboplatin and Etoposide Treatment With Standard Chemotherapy

NCT07544654Extrapulmonary Neuroendocrine Cancer (epNEC)

DrugsObrixtamig·Etoposide·Carboplatin

Boehringer Ingelheim

Phase 3

390

Arizona, California, Florida, Georgia, Illinois, Maryland, Massachusetts, Minnesota

2026-07-10

Recruiting

MoblO2 to Maintain Oxygenation

NCT07704567COPD (Chronic Obstructive Pulmonary Disease), Intersitital Lung Disease

Minnesota HealthSolutions

Not applicable

Colorado

2026-07-09

Recruiting

Consumer Evaluation of an Investigational Intermittent Catheter

NCT07714694Urinary Retention, Neurogenic Bladder

Hollister Incorporated

Not applicable

Illinois

2026-07-09

Recruiting

Evaluate Advanced Pneumatic Compression Device With Revised Compression Programming for Lymphedema Treatment

NCT07613931Lower Extremity Lymphedema

DrugsIC-Green·Indocyanine Green

Tactile Medical

Early Phase 1

Texas

2026-07-09

Recruiting

Safety, Dosage, and Microbiome Engraftment Study of MGT-006 for Ulcerative Colitis (ROOT Study)

NCT07913347Ulcerative Colitis (UC), Ulcerative Colitis, Active Moderate

DrugVancomycin Hydrochloride

Metagen Therapeutics, Inc.

Phase 1/2

Florida, Massachusetts, New York

2026-07-09

By invitation

A Comprehensive Digital Care Program for Migraine Management

NCT07642414Migraine, Migraine With Aura, Migraine Without Aura

Hinge Health, Inc

Not applicable

140

California

2026-07-09

Recruiting

A Study Evaluating the Efficacy and Safety of Xywav Expanded Dosing vs Placebo in Participants With Narcolepsy or IH

NCT07625280Narcolepsy, Idiopathic Hypersomnia

DrugXywav

Jazz Pharmaceuticals

Phase 3

120

Alabama, California, Colorado, Florida, Georgia, North Carolina, Ohio, Tennessee

2026-07-09

Recruiting

Comparative Self-collection for Cervical Cancer Screening Pivotal Study

NCT07758140HPV, HPV - Anogenital Human Papilloma Virus Infection

Mel Mont Medical

Not applicable

260

Arizona, California, Florida, Idaho, Montana, North Carolina, Texas, Washington

2026-07-09

Active, closed

A Study to Characterize the Safety and Immunogenicity of AZD6489 in Participants 60 Years of Age and Older (ARIES)

NCT07717840RSV Respiratory Syncytial Virus

AstraZeneca

Phase 1/2

164

California, Illinois, Kansas, Missouri, Nebraska

2026-07-08

Recruiting

A Study of the Pharmacokinetics, Biodistribution and Dosimetry of Granzyme-B Targeted [Cu-64]-Labeled PET Radiotracers in Adult Healthy Volunteers

NCT07774650Healthy Volunteer

Ratio Therapeutics, Inc.

Early Phase 1

Connecticut

2026-07-08

Recruiting

A Study of Orforglipron (LY3502970) Compared With Dulaglutide in Pediatric Participants With Type 2 Diabetes

NCT07668336Diabetes Mellitus, Type 2

DrugsDulaglutide·Orforglipron

Eli Lilly and Company

Phase 3

170

California, Connecticut, Georgia, Idaho, Kansas, New York, Oklahoma, Pennsylvania

2026-07-08

Recruiting

A Study of IDP-001 in Advanced or Metastatic Solid Tumors

NCT07602842Advanced Solid Tumor, Metastatic Solid Tumor, Head and Neck Squamous Cell Carcinoma, Cutaneous Squamous Cell Carcinoma

InduPro, Inc.

Phase 1/2

132

California, Florida, Indiana, New York, Texas

2026-07-08

Recruiting

A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus on Background Insulin

NCT07664553Type 2 Diabetes Mellitus

DrugElecoglipron

AstraZeneca

Phase 3

600

Arkansas, California, Colorado, Florida, Georgia, Maryland, New York, North Carolina

2026-07-08

Recruiting

Retinal Fundus Imaging and OCT Imaging for Ocular Detection of ATTR-CM

NCT07690436Transthyretin Amyloid Cardiomyopathy

AstraZeneca

Observational

500

California, Florida, Illinois, Massachusetts, Oregon, Tennessee

2026-07-08

Recruiting

The TRICURE US IDE Pivotal Study

NCT07528326Tricuspid Regurgitation (TR)

TRiCares

Not applicable

831

Georgia

2026-07-08

Recruiting

Intalight Reference Database Protocol for VG200D

NCT07751484The Focus of This Study is to Collect OCT Data on Normal Eyes

Intalight, Inc

Observational

350

California, Illinois, Indiana

2026-07-08

Recruiting

Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure

NCT06552637Heart Failure With Reduced Ejection Fraction

VisCardia Inc.

Not applicable

270

Indiana, Oklahoma, Pennsylvania, Texas

2026-07-08

Recruiting

A Study to Find an Efficacious and Safe Dose of CHF10067 (Zampilimab) in Participants With Idiopathic Pulmonary Fibrosis

NCT07516951Idiopathic Pulmonary Fibrosis

Chiesi Farmaceutici S.p.A.

Phase 2

240

Alabama, Florida, Missouri, South Carolina, Tennessee, Texas

2026-07-08

Recruiting

A Study of Theranostic Pair PD-32766D/T in Participants With Carbonic Anhydrase IX Positive Clear Cell Renal Cell Carcinoma

NCT07688187Clear Cell Renal Cell Carcinoma

PeptiDream Inc.

Phase 1

Nebraska

2026-07-07

Recruiting

Evaluation of the FARAFLEX Mapping and Pulsed Field Ablation System in Subjects With Atrial Fibrillation

NCT07575269Paroxysmal Atrial Fibrillation (PAF), Persistent Atrial Fibrillation

Boston Scientific Corporation

Not applicable

571

Arkansas, Georgia, Iowa, Massachusetts, New York, Ohio, Pennsylvania, South Carolina

2026-07-07

Recruiting

A Study in Adult Males With X-linked Congenital Nephrogenic Diabetes Insipidus to Test the Effects of NDI-5001 Given for Multiple Days and to Test How NDI-5001 is Tolerated and Taken up in the Body

NCT07525960Diabetes Insipidus

Otsuka Pharmaceutical Development & Commercialization, Inc.

Phase 1

California, Florida, Texas

2026-07-07

Not yet open

Measuring Knee Laxity and Pivot Shift in ACL-Deficient Patients

NCT07688967Anterior Cruciate Ligament (ACL) Tear

Arthroresearch LLC

Observational

Georgia

2026-07-07

Recruiting

A Study of VIRTUGUIDE System and DePuy Synthes Lapidus Implant in Participants Undergoing Lapidus Procedure

NCT07567092Hallux Valgus

DePuy Synthes Products, Inc.

Observational

100

Iowa, Michigan, North Carolina, Virginia

2026-07-07

Recruiting

A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin

NCT07662135Type 2 Diabetes Mellitus, Type 2 Diabetes With Chronic Kidney Disease

DrugElecoglipron

AstraZeneca

Phase 3

900

Arizona, California, Florida, Illinois, Massachusetts, Michigan, Minnesota, Missouri

2026-07-06

Recruiting

Evaluation of ETHY-001 for Safety, Tolerability, and Clinical Activity in Thyroid Eye Disease

NCT07885605Thyroid Eye Disease (TED), Graves' Disease, Eye Diseases, Hereditary, Eye Diseases

Ethyreal Bio, Inc.

Phase 1

Illinois, Nevada, North Carolina

2026-07-06

Recruiting

A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Alone or in Combination With Dapagliflozin Compared With Placebo in Adults With Type 2 Diabetes Mellitus

NCT07662044Type 2 Diabetes Mellitus

DrugsElecoglipron·Dapagliflozin

AstraZeneca

Phase 3

800

Alabama, California, Colorado, Connecticut, Florida, Georgia, Kansas, Kentucky

2026-07-06

Recruiting

Study to Evaluate ALN-CIDEB in Adults With Fibrotic Metabolic Dysfunction-Associated Steatohepatitis (MASH)

NCT07631637Metabolic Dysfunction-Associated Steatohepatitis (MASH)

DrugAln-Cideb

Regeneron Pharmaceuticals

Phase 2

150

Arizona, California, Florida, Louisiana, Texas

2026-07-06

Recruiting

Forward Treatment of Attention Deficit and Hyperactivity Using Solriamfetol (FOCUS-2)

NCT07717879ADHD

DrugsSolriamfetol A·Solriamfetol B

Axsome Therapeutics, Inc.

Phase 3

468

Alabama, Arkansas, California, Florida, Georgia, Kentucky, Massachusetts, Mississippi

2026-07-06

Recruiting

A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus

NCT07662213Type 2 Diabetes Mellitus

DrugsElecoglipron·Semaglutide

AstraZeneca

Phase 3

1,200

Alabama, Arizona, California, Connecticut, Florida, Georgia, Idaho, Illinois

2026-07-06

Active, closed

A Clinical Trial to Evaluate the Effects of Rejuvaskin Eczema Body Wash and Skin Recovery Cream in Adults With Eczema-Prone Skin

NCT07700745Eczema, Atopic Dermatitis, Eczema-Prone Skin

Rejuvaskin

Not applicable

Nevada

2026-07-06

Recruiting

A Usability Study of a Multi-channel ECG Monitoring Device

NCT07388355Healthy Adult Participants, Heart Disease, Arrythmia, Cardiac

Wearlinq

Not applicable

500

North Carolina

2026-07-06

Recruiting

A Phase III Study to Investigate the Efficacy and Safety of the Combination of Elecoglipron and Dapagliflozin in Adults With Type 2 Diabetes Mellitus

NCT07662109Type 2 Diabetes Mellitus

DrugsElecoglipron·Dapagliflozin

AstraZeneca

Phase 3

2,000

Alabama, Arkansas, California, Florida, Georgia, Illinois, Indiana, Iowa

2026-07-06

Recruiting

A Study of Ifinatamab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01D/LIGHTBEAM-U01)

NCT07630974Malignant Neoplasm

DrugIfinatamab Deruxtecan

Merck Sharp & Dohme LLC

Phase 1/2

134

California, Colorado, Florida, Iowa, Massachusetts, Michigan, Missouri, New Jersey

2026-07-06

Active, closed

Use of Force Feedback Instruments With the da Vinci Surgical System, Model IS5000 for Mitral Valve Repair

NCT07655505Mitral Regurgitation (MR)

Intuitive Surgical

Not applicable

Georgia, New York, Washington

2026-07-06

Recruiting

A Phase 1 Study of VK3019 in Overweight and Obese Adults Without Comorbidities

NCT07846033Obese Adults

Viking Therapeutics, Inc.

Phase 1

California

2026-07-06

Recruiting

Early Feasibility Study (EFS) of the Nyra Cardiac Leaflet Enhancer (CARLEN) System

NCT07503236Mitral Regurgitation Functional

Nyra Medical, Inc.

Not applicable

California, Michigan, Ohio

2026-07-02

Active, closed

A Clinical Trial to Evaluate the Effects of Super Lungs Liquid Drops on Respiratory Comfort, Airway Soothing, and Overall Well-Being

NCT07694284Coughing, Throat Irritation

SuperBonsai Inc.

Not applicable

Nevada

2026-07-02

Recruiting

A Post-Market Assessment of the Safety and Performance of the TriClip™ System

NCT07586995Tricuspid Regurgitation (TR)

Abbott Medical Devices

Observational

1,000

Arizona, California, Illinois, New York, Texas, Virginia

2026-07-02

Recruiting

Parasternal Extravascular ICD System Pivotal Clinical Investigation (ALARION EV) Study

NCT07324031Ventricular Arrythmia, Ventricular Fibrillation, Ventricular Tachycardia

AtaCor Medical, Inc.

Not applicable

280

Arizona, Arkansas, California, District of Columbia, Florida, Georgia, Illinois, Kentucky

2026-07-02

Recruiting

Phase 1b/2 Study of IV Sarilumab in Adult With RA

NCT07704580Rheumatoid Arthritis

DrugSarilumab

Sanofi

Phase 1/2

140

Colorado, Florida, Pennsylvania, Texas

2026-07-02

Recruiting

Symbiotic-Lung-14: A Study to Learn About the Study Medicine Called PF08634404 in Combination With Chemotherapy in Adult Participants With Transformed Small Cell Lung Cancer

NCT07476287Small Cell Lung Cancer, Small Cell Lung Cancer ( SCLC ), Transformed Small Cell Lung Cancer, Lung Neoplasms

DrugPF-08634404

Pfizer

Phase 2

California, Illinois, New Jersey, New York

2026-07-02

Recruiting

A Study to Evaluate Adverse Events and Change in Disease Activity of Intravenous ABBV-706 Versus Standard of Care in Adult Participants With Relapsed/Refractory Small Cell Lung Cancer

NCT07365241Small Cell Lung Cancer

DrugsABBV-706·Amrubicin·Lurbinectedin·Topotecan

AbbVie

Phase 3

531

Alabama, Arizona, California, Florida, Georgia, Illinois, Indiana, Kentucky

2026-07-02

Recruiting

Personalized Prone Immobilization for Accelerated Partial Breast Radiotherapy

NCT07711847Invasive Breast Cancer Early Stages, Ductal Carcinoma In Situ, DCIS

HeroSupport SA

Not applicable

New York

2026-07-02

Active, closed

A Clinical Trial to Evaluate the Effects of Larineco Remineralizing Gum on Oral Health, Breath Freshness, Tooth Sensitivity, and Gum Comfort

NCT07692581Bad Breath, Tooth Sensitivity

Larine C Corporation

Not applicable

Nevada

2026-07-02

Recruiting

Axonics R20 Post-Market Clinical Follow-up (PMCF) Study for the Indication of Fecal Incontinence

NCT07499258Fecal Incontinence

Axonics, Inc.

Observational

New York, Ohio, Tennessee, Texas

2026-07-02

Recruiting

Clinical Trial in Patients With Barth Syndrome- 4TAZPower

NCT07531251Barth Syndrome

DrugElamipretide

Stealth BioTherapeutics Inc.

Phase 4

Massachusetts

2026-07-02

Recruiting

Efficacy and Safety of Intranasal Cenegermin in Adult Participants With Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)

NCT07453888Non-Arteritic Anterior Ischemic Optic Neuropathy

DrugCenegermin

Dompé Farmaceutici S.p.A

Phase 3

272

California, Colorado, Florida, Georgia, Illinois, Kentucky, Maryland, Massachusetts

2026-07-01

Recruiting

LINQ® Procedure vs. Conventional Medical Management for Sacroiliac Dysfunction

NCT07558278Sacroiliac Joint Pain

PainTEQ, LLC

Phase 4

200

Texas

2026-07-01

Recruiting

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Crinecerfont in Participants With Classic Congenital Adrenal Hyperplasia (CAH) Who Are Less Than 4 Years Old

NCT07536269Congenital Adrenal Hyperplasia

DrugCrinecerfont

Neurocrine Switzerland GmbH

Phase 2

California, Colorado, Connecticut, Georgia, Illinois, Indiana, Michigan, Minnesota

2026-07-01

Recruiting

An Open-Label Study to Evaluate PF-07994525 in Participants With Advanced Cancers

NCT07426757Advanced Malignancies, Advanced Cancer

DrugMidazolam

Pfizer

Phase 1

120

Colorado, Connecticut, Florida, Georgia, Ohio, Tennessee

2026-07-01

Active, closed

A Single-Arm, Blinded, Fluorescent PSMA Histopathology Trial of AS1986NS

NCT06906471Prostate Cancer, Prostate Cancer (Adenocarcinoma), Fluorescence Imaging

Antelope Surgical Solutions, Inc

Phase 1/2

Florida, New York

2026-07-01

Recruiting

A Study in Patients With Metastatic Castration-Resistant Prostate Cancer

NCT07719361Metastatic Castration Resistant Prostate Cancer, mCRPC, mCRPC (Metastatic Castration-resistant Prostate Cancer), Prostatic Neoplasms

Flare Therapeutics Inc.

Phase 1

California, Massachusetts, Michigan, New Jersey, South Carolina, Tennessee, Texas

2026-07-01

Not yet open

KPAP Adherence Crossover Study

NCT06413134Obstructive Sleep Apnea

SleepRes Inc.

Not applicable

Tennessee

2026-07-01

Recruiting

Registry of Outcomes of Dezawa MuseCells®

NCT07645989Osteoarthritis (OA), Longevity, Wound Care, Pain

MuseCell Innovations Pte LTD

Observational

5,000

Florida

2026-07-01

Recruiting

Pridopidine Phase 3 Study in Huntington's Disease

NCT07609108Huntington Disease

DrugPridopidine

Prilenia

Phase 3

400

Alabama, California, District of Columbia, Florida, Illinois, Kansas, Maryland, Massachusetts

2026-07-01

Recruiting

Study to Assess Effects of Ublituximab in Pediatric Participants With Relapsing Forms of Multiple Sclerosis

NCT07220252Relapsing Multiple Sclerosis

DrugsUblituximab·Fingolimod

TG Therapeutics, Inc.

Phase 2/3

240

Utah

2026-07-01

Recruiting

Chronic Evaluation of Novel Pacemaker System

NCT06056817Ventricular Pacing With Rate Response, Bradycardia

Calyan Technologies

Not applicable

Minnesota

2026-07-01

Recruiting

A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine

NCT07645924Migraine

DrugElismetrep

TriGemX Bio, Inc.

Phase 3

1,800

Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Georgia, Illinois

2026-07-01

Not yet open

Prospective Observational Study of Smartphone-Based AI Self-Monitoring During Non-Surgical Treatment for Thyroid Eye Disease (THYROSCOPE)

NCT07623993Thyroid Eye Disease (TED), Graves Ophthalmopathy, Thyroid Associated Ophthalmopathies

THYROSCOPE INC.

Observational

200

California

2026-07-01

Recruiting

Proof of Concept Study of Vaginal AZU-101 in Vulvovaginal Atrophy in Postmenopausal Women

NCT06197568Vulvo Vaginal Atrophy (VVA)

Azure Biotech Inc.

Phase 2

Minnesota

2026-07-01

By invitation

Pilot Study to Evaluate Changes in Intra-Epidermal Nerve Fiber Density (IENFD) in Patients With Small-Fiber Neuropathy

NCT07704931Small Fiber Neuropathy

TriCity Research Center

Not applicable

Nebraska

2026-07-01

Recruiting

Renal Impairment Study for Oral EC5026

NCT07694544Chronic Kidney Disease

DrugEC5026

EicOsis Human Health Inc.

Phase 1

California

2026-07-01

Not yet open

Clinical Validation of AI-Based Quantitative Eye Movement Analysis From Smartphone 9-Gaze Videos (Glandy EOM)

NCT07623837Ocular Motility Disorders, Strabismus, Extraocular Muscle Dysfunction, Thyroid Eye Disease

THYROSCOPE INC.

Observational

1,000

California

2026-07-01

Recruiting

Safety and Efficacy of AIV007 Periocular Injection in Patients With Neovascular Age-Related Macular Degeneration

NCT07557121Neovascular (Wet) Age-Related Macular Degeneration

DrugEYLEA (aflibercept)

AiViva BioPharma, Inc.

Phase 2

California, Texas

2026-07-01

Not yet open

Post-market Clinical Investigation Plan: Collagen Dura Regeneration Membrane - Repair (DMR)

NCT07371091Repair of Dura Mater

Collagen Matrix

Observational

110

Illinois, Massachusetts

2026-07

Not yet open

A Phase 1/2 Study of Safety and Tolerability of MT-125 With Chemoradiation in Patients With Newly Diagnosed MGMT Methylated Glioblastoma

NCT07604285Glioblastoma

DrugMT-125

Myosin Therapeutics Inc.

Phase 1/2

Arizona, Florida, Minnesota

2026-07

Not yet open

Effect of ZenRest™ Lotus Seed & Rice Germ Extract Blend on Sleep Quality in Menopausal Women

NCT07678359Sleep Quality, Menopause

Nutraland USA, Inc.

Not applicable

California

2026-07

Not yet open

Evaluation of AppleX™ Apple Extract on Anti-Inflammatory and Healthy Aging Effects

NCT07678346Systemic Inflammation (hsCRP), Healthy Aging, Vitality, Healthy Adult Participants

Nutraland USA, Inc.

Not applicable

California

2026-07

Recruiting

A Multi-Site Study to Assess the Effect of Availability of a Heated Tobacco Product on Smoking Abstinence Among Current Primary Cigarette Smokers

NCT07710820Smoking, Tobacco

RAI Services Company

Not applicable

1,060

Florida, Illinois, Nevada, Texas

2026-07

Not yet open

A Comparison of a Medication Adherence Platform (FORTISKAP™) vs. Usual Care in Subjects on Oral Medications for the Treatment of Interstitial Lung Disease, Sarcoid and Pulmonary Hypertension

NCT07613216Idiopathic Pulmonary Fibrosis (IPF), Sarcoidosis Lung, Pulmonary Hypertension, Usual Interstitial Pneumonia

Cosmos Rx, Inc

Observational

100

Virginia

2026-07

Not yet open

Study of the Shockwave Medical SkyRunner Carotid Intravascular Lithotripsy (IVL) System for the Treatment of Calcified Carotid Arteries Prior to Trans-Femoral Stenting (SKYWARD Trans-Femoral IDE [Investigational Device Exemption] Study)

NCT07512128Carotid Artery Calcification, Carotid Artery Diseases

Shockwave Medical, Inc.

Not applicable

185

Arizona, Colorado, Florida, Georgia, Louisiana, Missouri, New York, North Carolina

2026-07

Recruiting

Caris Chromoseq Data Collection

NCT07680868Acute Myeloid Leukemia (AML), Myelodysplastic (MDS) / Myeloproliferative (MPN) Diseases, Myelodysplatic Syndromes, Myeloproliferative Neoplasm

Caris Science, Inc.

Observational

300

Arizona

2026-07

Recruiting

Cardiac Magnetic Resonance and Echocardiography Study With Acoramidis

NCT07695701Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM), Amyloidosis, Amyloid Cardiomyopathy, Transthyretin Amyloidosis

Eidos Therapeutics, a BridgeBio company

Phase 4

150

Missouri

2026-07

Not yet open

A Study of CLSP 5282 in HLA-A*03:01 Positive Adult Patients With Solid Tumors (SENTINEL-101)

NCT07650357Advanced Solid Tumor, Non Small Cell Lung Cancer, Pancreatic Carcinoma, Colorectal Cancer

Clasp Therapeutics, Inc.

Phase 1

140

North Carolina, Pennsylvania, Tennessee, Texas

2026-07

Recruiting

US Zamto-cel Autoimmune Diseases

NCT06708845Lupus Nephritis, Systemic Lupus Erythematosus, Systemic Sclerosis (SSc), Diffuse Cutaneous Systemic Sclerosis

DrugsZamtocabtagene autoleucel·Fludarabine·Cyclophosphamide

Miltenyi Biomedicine GmbH

Phase 1

Wisconsin

2026-07

Recruiting

A Study to Assess Adverse Events and Change in Disease Activity When Intravenous (IV) Pivekimab Sunirine is Given in Combination With Oral Venetoclax and IV or Subcutaneous Azacitidine in Adult Participants With Acute Myeloid Leukemia (AML)

NCT07581002Acute Myeloid Leukemia

DrugsPivekimab Sunirine·Azacitidine·Venetoclax

AbbVie

Phase 2/3

660

California, Florida, Georgia, Missouri, New York, Texas

2026-06-30

Recruiting

Low-dose Carbon Monoxide (HBI-002) Trial to Evaluate Safety, Tolerability, PK, and Biomarkers in Parkinson's Disease

NCT07005180Parkinson Disease

Hillhurst Biopharmaceuticals, Inc.

Phase 2

California, Florida, Massachusetts, Michigan, New York, Washington

2026-06-30

Recruiting

A Clinical Trial of MK-7262 and Enlicitide in Participants With High Lipoprotein(a) (MK-7262-004)

NCT07614984Lipoprotein(a)

DrugsHRS-5346·Enlicitide

Merck Sharp & Dohme LLC

Phase 2

750

Alabama, California, Connecticut, Florida, Maryland, Michigan, Minnesota, Montana

2026-06-30

Recruiting

A Phase 1 Study to Evaluate OPB-201 in Recurrent Endometrial and Platinum-resistant Ovarian Cancer.

NCT07664735Endometrial Cancer Recurrent, Endometrial Cancer, Advanced Endometrial Cancer, Ovarian Cancer

Outpace Bio, Inc.

Phase 1

California, Georgia, Michigan, Minnesota, Texas

2026-06-30

Active, closed

A Study to Test Whether BI 3034701 Helps People to Lose Weight Who Live With Obesity or Overweight

NCT07662122Obesity, Overweight

DrugBI 3034701

Boehringer Ingelheim

Phase 2

344

Alabama, California, Florida, Georgia, Kentucky, Michigan, Missouri, North Carolina

2026-06-30

Not yet open

GRIP: Gordian Robotic Integrated Port Closure Study

NCT07649915Robotic Surgery

Gordian Surgical

Not applicable

Pennsylvania

2026-06-30

Recruiting

A Study of Real-World Characteristics, Treatment Patterns, and Outcomes Among mCRPC Patients Previously Treated With an Androgen Receptor Pathway Inhibitor, Taxane-Based Chemotherapy, and Lutetium-177 Vipivotide Tetraxetan

NCT07677267Prostatic Neoplasms, Castration-Resistant

Novartis Pharmaceuticals

Observational

1,067

New Jersey

2026-06-30

Not yet open

Use of QRX3 for Acute Tubular Necrosis Type of Renal Failure in Hospitalized Patients ( QRX-3 in ARF)

NCT07161843Acute Renal Failure (ARF), Acute Tubular Necrosis

DrugEseronate

Ebima Clifford Okundaye

Phase 2/3

500

Texas

2026-06-30

Recruiting

Phase 1, Safety and Tolerability Study of XmAb541 and XmAb808 in Advanced Solid Tumors

NCT07593092Ovarian Cancer

DrugXmAb541

Xencor, Inc.

Phase 1

New York, Texas

2026-06-30

Not yet open

FG001 Near-Infrared Fluorescence Imaging During Tumor Resection in Newly Diagnosed High-Grade Glioma

NCT07609472High-Grade Glioma (WHO III-IV)

FluoGuide A/S

Phase 2

Florida, New Hampshire, Pennsylvania, Texas, Utah

2026-06-30

Recruiting

An Open-Label, Single-Arm Study to Investigate the Efficacy and Safety of North Star Desiccated Porcine Thyroid Extract Tablets.

NCT07747103Hypothyroidism

Neuvosyn Laboratories, LLC

Phase 3

466

California, Colorado, Florida, Idaho, Massachusetts, Nevada, North Carolina, South Carolina

2026-06-30

Recruiting

EXACT Study: A Blinded Study in Patients With Alport Syndrome to Evaluate Exaluren Efficacy and Safety

NCT07523581Alport Syndrome, X-Linked, Alport Syndrome, Autosomal Recessive

Eloxx Pharmaceuticals, Inc.

Phase 2

California, Colorado, Minnesota, New Jersey, Pennsylvania, Texas

2026-06-30

Not yet open

Pharmacokinetics of Y-4 Tablets With Pregabalin Capsules and Riluzole Tablets in U.S. Healthy Participants

NCT07618715Healthy Male and Female Subjects

DrugsY-4·Riluzole·Pregabalin

Neurodawn Pharmaceutical Co., Ltd.

Phase 1

New Jersey

2026-06-30

Recruiting

Sleep More, Stress Less: 90-Day Trial of Neuralli Mood

NCT07717385Psychological Stress, Sleep Disturbance, Anxiety Symptoms, Depressive Symptoms

Efforia, Inc

Not applicable

100

New York

2026-06-30

Recruiting

Detection of Atrial Fibrillation Using PPG From Smartphone Cameras

NCT07779213Atrial Fibrillation (AF)

Happitech BV

Observational

554

Arkansas, Colorado, Louisiana, Oklahoma

2026-06-30

Recruiting

A Study of Real-World Characteristics, Treatment Patterns, and Clinical Outcomes in Patients With Metastatic Castration-Resistant Prostate Cancer

NCT07677254Prostatic Neoplasms, Castration-Resistant

Novartis Pharmaceuticals

Observational

17,111

New Jersey

2026-06-30

Recruiting

Phase 1/2 Study of Intravenous Injection of STX-003 in Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab

NCT07751042Advanced Solid Tumor

DrugKeytruda

Strand Therapeutics Inc.

Phase 1/2

220

Arizona, Massachusetts, Tennessee

2026-06-30

Not yet open

NeuroCuple to Mitigate Post-Wisdom Teeth Extraction Opioid Risks

NCT07461506Wisdom Teeth, Wisdom Teeth Extraction or Jaw Implant

nCap Medical

Not applicable

120

Pennsylvania

2026-06-30

Not yet open

Evaluation of the Safety and Effectiveness of the CORUS™ Posterior Cervical Stabilization System 3D (PCSS 3D) for the Treatment of 2-level Cervical Degenerative Disease

NCT07721493Degenerative Disc Disease(DDD)

Providence Medical Technology, Inc.

Not applicable

225

Kentucky

2026-06-30

Recruiting

A Study Evaluating the Prophylactic Use of Tocilizumab to Prevent Cytokine Release Syndrome With Ramantamig Administration in Participants With Relapsed/Refractory Multiple Myeloma

NCT07589634Multiple Myeloma

DrugsRamantamig·Tocilizumab

Janssen Research & Development, LLC

Phase 2

230

Arizona, California, Colorado, Missouri, Ohio, Tennessee, Utah

2026-06-30

Active, closed

A Clinical Study of MK-8527 in Healthy Participants (MK-8527-021)

NCT07661108Healthy

DrugsMK-8527·Probenecid·Itraconazole

Merck Sharp & Dohme LLC

Phase 1

Florida

2026-06-30

Not yet open

Study of Shunt Flow Under Different Valve Settings Using a Wireless Sensor

NCT07679035Hydrocephalus

Rhaeos, Inc.

Not applicable

Illinois

2026-06-30

Recruiting

Symbiotic-Lung-10: A Study to Learn About PF-08634404 Alone or in Combination in Early-stage or Locally Advanced NSCLC

NCT07489066Carcinoma, Non-Small-Cell Lung, Lung Cancer (NSCLC), Lung Neoplasms

DrugPF-08634404

Pfizer

Phase 2

120

Alabama, California, Georgia, Illinois, Nebraska, New Mexico, Tennessee

2026-06-30

Recruiting

To Evaluate the Effect of EXPD-101/FXS7553 Compared With Placebo in Patients With COPD Over 52 Weeks of Treatment

NCT07684820Chronic Obstructive Pulmonary Disease (COPD)

Expedition Therapeutics, Inc

Phase 2

600

Arizona, California, Colorado, Florida, Georgia, Indiana, Kansas, Louisiana

2026-06-30

Not yet open

Return to Activity After Surgery for Lumbar Disc Herniation

NCT07667348Lumbar Disc Herniation Surgery, Disc Herniation

Intrinsic Therapeutics

Phase 4

120

Louisiana

2026-06-30

Not yet open

AUR103 Calcium in Advanced Neuroendocrine Tumours (BHARAT-3 Study)

NCT07640737Neuroendocrine (NE) Tumors, Advanced NET of GI Origin

Aurigene Discovery Technologies Limited

Phase 2

Arizona, California, Florida, Minnesota, Pennsylvania

2026-06-30

Recruiting

A Study to Learn How the Study Medicine Called Atirmociclib is Handled by the Body in People With Normal Liver Function and Different Levels of Liver Disease

NCT07677358Hepatic Impairment, Healthy, Hepatic Insufficiency, Healthy Adults

DrugAtirmociclib

Pfizer

Phase 1

Florida

2026-06-29

Recruiting

A Phase 3 Study to Evaluate Claseprubart in Adults With Generalized Myasthenia Gravis (EMERGE)

NCT07647510Myasthenia Gravis, Generalized

DrugClaseprubart

Dianthus Therapeutics

Phase 3

195

California, Florida, North Carolina, Texas

2026-06-29

Recruiting

Idiopathic Pulmonary Fibrosis (IPF)-Related Chronic Cough Reduction With Nalbuphine Extended-Release (NAL ER) Tablets

NCT07671911Idiopathic Pulmonary Fibrosis

DrugNalbuphine

Trevi Therapeutics

Phase 3

306

California, Colorado, Florida, Louisiana, Missouri, Nevada, New York, North Carolina

2026-06-29

Recruiting

A Phase 2b Dose-Ranging Study to Evaluate the Efficacy and Safety of ENV-294 in Adults With Moderate-to-Severe Atopic Dermatitis

NCT07643766Atopic Dermatitis

DrugENV-294

Enveda Therapeutics

Phase 2

200

California, Florida, Indiana, Texas

2026-06-29

Recruiting

Safety and Drug Concentrations of REGN20934 in Adults With Overweight or Obesity

NCT07594093Overweight or Obesity

Regeneron Pharmaceuticals

Phase 1

California

2026-06-29

Recruiting

Hydration & Female Life Stages

NCT07653620Dehydration, Menstruation, Pre-menopause, Peri-menopausal Women

PepsiCo Global R&D

Not applicable

Florida, New York

2026-06-29

Recruiting

Study of NTB-928 in R/R OC

NCT07690189Relapsed/Refractory Ovarian Carcinoma

TeneoSeven, Inc.

Phase 1

Alabama, Nebraska, New York, Texas

2026-06-29

Recruiting

A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM

NCT07667803Weight Management

DrugElecoglipron

AstraZeneca

Phase 3

4,500

Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia

2026-06-29

Recruiting

A Study Comparing Siplizumab With Rabbit Anti-Thymocyte Globulin to Help the Body Accept a Kidney Transplant

NCT07508787Renal Transplant Failure and Rejection

DrugsSiplizumab·Rabbit anti-thymocyte globulin·Thymoglobulin

Nefro Avillion Clinical Development, LLC

Phase 2

120

California, Florida, Georgia, Kansas, Louisiana, Massachusetts, Michigan, New Jersey

2026-06-29

Recruiting

An Early-Stage Study in Multiple Clinics of How Afimkibart May Affect the Body's Processing of Medicines That Rely on Cytochrome P450 Enzymes in Participants With Ulcerative Colitis

NCT07665723Active Ulcerative Colitis

DrugsDextromethorphan·Caffeine·Afimkibart·Omeprazole

Hoffmann-La Roche

Phase 1

California, Florida

2026-06-29

Recruiting

ILKN421H Plus Pembrolizumab in Advanced Non-Small Cell Lung Cancer

NCT07452224Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

DrugPembrolizumab

iLeukon Therapeutics, Inc.

Phase 2

California, Texas

2026-06-29

Recruiting

A Phase 3 Study of Rezpegaldesleukin (NKTR-358) for Patients ≥ 12 Years of Age With Moderate-to-Severe Atopic Dermatitis

NCT07690371Moderate-to-Severe Atopic Dermatitis

DrugRezpegaldesleukin

Nektar Therapeutics

Phase 3

510

Arizona, Arkansas, California, Florida, Georgia, Idaho, Illinois, Kentucky

2026-06-29

Recruiting

Study of AZD0120 in Newly Diagnosed Multiple Myeloma Ineligible for ASCT

NCT07764978Newly Diagnosed Multiple Myeloma

DrugsAZD0120·Isatuximab·Bortezomib·Daratumumab

AstraZeneca

Phase 3

750

Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Iowa

2026-06-26

Recruiting

Study to Determine if BHV-1300 is Effective and Safe in Adults With Graves' Disease

NCT07661056Graves Disease

DrugBHV-1300

Biohaven Therapeutics Ltd.

Phase 3

300

Arizona, California, District of Columbia, Florida, Georgia, Illinois, Kansas, Louisiana

2026-06-26

By invitation

A Multiphase Operational and Environmental Assessment of Lunar Surface Habitation, Lunar Gateway Transit Systems, and Acceleration Pathways for Sustained Human Habitation of the Martian Surface

NCT07546461Extraterrestrial Habitation Systems, Lunar Surface Habitation, Lunar Water-Ice Resource Assessment, In-Situ Resource Utilization (ISRU)

Truway Health, Inc.

Observational

New York

2026-06-26

Recruiting

A Trial to Assess TEV-56286 at Different Doses in Healthy Participants

NCT07674940Healthy Volunteers

DrugEmrusolmin

Teva Branded Pharmaceutical Products R&D LLC

Phase 1

Florida

2026-06-26

Recruiting

FORWARD: Functional Outcomes in Real-World Treatment And Revascularization of Non-dominant and Distal M2 Occlusions

NCT07749170Acute Ischemic Stroke, Acute Ischemic Stroke (AIS) Related to a Distal Occlusion

Penumbra Inc.

Observational

250

Colorado, Connecticut, Kentucky, Pennsylvania, South Carolina, Tennessee

2026-06-26

Recruiting

Trial to Evaluate the Efficacy and Safety of LYT-100 (Deupirfenidone) Compared to Pirfenidone in Adults With Idiopathic Pulmonary Fibrosis (IPF)

NCT07284602Idiopathic Pulmonary Fibrosis (IPF)

DrugsDeupirfenidone·Pirfenidone

PureTech

Phase 3

1,100

California, Florida, Massachusetts, Nevada, North Carolina, Pennsylvania, South Carolina, Tennessee

2026-06-26

Recruiting

A Study to Investigate Cabotegravir Ultra Long-Acting (CAB ULA) Plus Rilpivirine Ultra Long-Acting (RPV ULA) in Adults and Adolescents With HIV Who Are Virologically Suppressed

NCT07650916HIV Infections

DrugsCab Ula·Rpv La·Cabotegravir

ViiV Healthcare

Phase 3

564

Arizona, California, Connecticut, District of Columbia, Florida, Georgia, Maryland, Michigan

2026-06-25

Recruiting

A Long-term Study of KT-621 Administered Orally to Participants With Asthma Previously Enrolled in a KT-621 Asthma Study

NCT07677059Asthma (Diagnosis)

DrugKT-621

Kymera Therapeutics, Inc.

Phase 2

264

Florida, Texas

2026-06-25

Recruiting

A Study of Depemokimab in Participants of 6 to 11 Years of Age

NCT07671001Asthma

DrugDepemokimab

GlaxoSmithKline

Phase 3

Alabama, Colorado, South Dakota

2026-06-25

Recruiting

A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain

NCT07641517Osteoarthritis, Knee, Chronic Pain

DrugLY4065967

Eli Lilly and Company

Phase 2

150

Alabama, Arizona, California, Connecticut, Florida, Georgia, Illinois, Louisiana

2026-06-25

Not yet open

Radicle Energy VBMTM: A Study Assessing the Impact of Health and Wellness Products on Fatigue and Related Health Outcomes

NCT07653724Fatigue, Cognitive Function, Global Mental Health, Sleep Disturbance

Radicle Science

Not applicable

550

California

2026-06-25

Recruiting

Study of LX2006 Gene Therapy in Friedreich Ataxia Cardiomyopathy

NCT07721025Friedreich Ataxia, Cardiomyopathy, Secondary

Lexeo Therapeutics

Phase 2

Florida

2026-06-25

Recruiting

A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

NCT07621237Major Depressive Episode (MDE), Major Depressive Disorder (MDD), Depression

DrugCyclobenzaprine

Tonix Pharmaceuticals, Inc.

Phase 2

360

Arizona, California, Florida, Georgia, Illinois, Louisiana, Maryland, Massachusetts

2026-06-25

Recruiting

Effectiveness of Audio Cues to Achieve Positional Therapy in Patients With Positional Obstructive Sleep Apnea

NCT07714330Obstructive Sleep Apnea (OSA), Positional Obstructive Sleep Apnea

SleepDev, Inc

Not applicable

California

2026-06-25

Recruiting

Safety and Efficacy of SUM-191 for Patients With Bacterial Conjunctivitis

NCT07565103Bacterial Conjunctivitis

Senju USA, Inc.

Phase 1/2

426

Texas

2026-06-25

Recruiting

Wearable Sensory Prosthesis to Improve Coordination, Walking, and Physical Activity

NCT07554443Peripheral Neuropathy With Type 2 Diabetes, Peripheral Neuropathy Grade 2 or Greater, Balance, Balance Impairment, Gait Disorders, Fatigue

RxFunction Inc.

Not applicable

Florida

2026-06-25

Recruiting

Forward Treatment of Attention Deficit and Hyperactivity Using Solriamfetol (FOCUS-3)

NCT07717892ADHD

DrugsSolriamfetol A·Solriamfetol B

Axsome Therapeutics, Inc.

Phase 3

468

Alabama, Arkansas, California, Florida, Georgia, Kentucky, Massachusetts, Mississippi

2026-06-25

Recruiting

A Study of LY4174794 in Participants With Obesity or Overweight Who Are Otherwise Healthy

NCT07654972Obesity, Overweight

Eli Lilly and Company

Phase 1

116

Texas, Utah

2026-06-24

Recruiting

A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors

NCT07705334Advanced or Metastatic Solid Tumors, Triple Negative Breast Cancer (TNBC), HR+ Breast Cancer, Colon Cancer

SHY Therapeutics

Phase 1

Arizona, Texas

2026-06-24

Not yet open

rTMS Device for Improvement of Obsessive and Compulsive Behaviors

NCT07679750Obsessive-Compulsive Behavior

BTL Industries Ltd.

Not applicable

Arizona, Florida, Massachusetts

2026-06-24

Recruiting

An Open-label, Single-arm Study of Prophylaxis for Datopotamab Deruxtecan (Dato-DXd) -Related Stomatitis in Eligible Patients With Metastatic or Inoperable Locally Recurrent Breast Cancer or Locally Advanced or Metastatic Epidermal Growth Factor Receptor-Mutated Non-small Cell Lung Cancer.

NCT07357597Stomatitis

DrugDato-DXd

AstraZeneca

Phase 4

100

Arizona, Arkansas, California, District of Columbia, Florida, Georgia, Idaho, Illinois

2026-06-24

Active, closed

A Clinical Trial to Evaluate the Effects of Super Liver Liquid Drops on Gut Health, Digestive Comfort, and Daily Energy Levels

NCT07742657Gastrointestinal Symptoms, Bloating, Digestive Discomfort, Low Energy Levels

SuperBonsai Inc.

Not applicable

Nevada

2026-06-24

Recruiting

A Study to Assess Safety, Tolerability, and How Single and Multiple Injections or Infusions of ABBV-313 Affects the Body of Adult Participants

NCT07673120Healthy Volunteers

AbbVie

Phase 1

California, Illinois

2026-06-24

Recruiting

A Study to Evaluate the Efficacy and Safety of Belantamab Mafodotin in Combination With Cyclophosphamide, Bortezomib, and Dexamethasone in Adult Participants With Newly Diagnosed Amyloid Light Chain (AL) Amyloidosis

NCT07224672Amyloidosis

DrugsBelantamab mafodotin·Bortezomib·Dexamethasone·Cyclophosphamide

GlaxoSmithKline

Phase 2

California, Colorado, Connecticut, Massachusetts, Minnesota, New Jersey, Tennessee, Utah

2026-06-24

Recruiting

A Study of MZE782 in Adults With PKU

NCT07694440Phenylketonuria (PKU)

Maze Therapeutics

Phase 2

California, Illinois, Indiana, Kentucky, Pennsylvania, Tennessee

2026-06-23

Recruiting

Post-Approval Study of PALMAZ MULLINS XD™ in Treating Pulmonary Artery Stenosis

NCT07122518Pulmonary Artery Stenosis

Cordis US Corp.

Observational

California, Georgia, Michigan, Missouri, Nebraska, Ohio, Pennsylvania, Texas

2026-06-23

Recruiting

Study of Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension

NCT07511361Hypertension, Acute Severe Hypertension, Hypertensive Emergency, Hypertensive Urgency

Kardigan, Inc.

Phase 2

140

Colorado, Florida, Illinois, Michigan, New York, Ohio, South Carolina, Tennessee

2026-06-23

Recruiting

A First-in-human (FIH), Phase 1 Study of ML261, an Autologous Potency Enhanced Anti-DLL3 CAR T Cell Therapy, in Participants With R/R SCLC or Select NECs (SPECTRAL-1)

NCT07488923Small Cell Lung Cancer (SCLC ), Extrapulmonary Neuroendocrine Carcinoma (EP-NEC), Gastroenteropancreatic NEC (GEP NEC), Neuroendocrine Prostate Cancer (NEPC)

Moonlight Bio, Inc

Phase 1

110

Missouri, New Jersey, New York, Tennessee, Texas, Washington

2026-06-23

Recruiting

Phase 1 Study on the Safety, Tolerability, and Pharmacokinetics of JST-018 in Healthy Adults

NCT07595458Antiviral Drug

Just-Evotec Biologics

Phase 1

Nevada

2026-06-23

Recruiting

Study of AGN-151607-DP to Assess Adverse Events and Change in Disease Activity in Adult Participants With Upper Limb Essential Tremor

NCT07673107Upper Limb Essential Tremor

DrugAGN-151607-DP

AbbVie

Phase 2

California, Connecticut, Florida, Kansas, New York, North Carolina, Ohio, Tennessee

2026-06-23

Recruiting

A Study to Assess Nipocalimab Concentrations in Breast Milk of Healthy Lactating Women

NCT07669077Healthy

DrugNipocalimab

Janssen Research & Development, LLC

Phase 1

Utah

2026-06-23

Recruiting

BEACON - Phase III Clinical Study of Rugonersen in Angelman Syndrome.

NCT07605429Angelman Syndrome

OHB Pediatrics Ltd.

Phase 3

165

California, Colorado, Florida, Illinois, North Carolina, Tennessee

2026-06-23

Recruiting

KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIST in 1st Line Setting (SynerGIST-1st Line)

NCT07406633GIST - Gastrointestinal Stromal Tumor, GIST, GIST Metastatic Cancer, Gastro Intestinal Stromal Tumour

DrugsKQB198·Imatinib

Kumquat Biosciences Inc.

Phase 2

California, Florida, Illinois, Iowa, Massachusetts, Michigan, Minnesota, New York

2026-06-23

Recruiting

Cevostamab in Combination With Pomalidomide and Dexamethasone Versus Standard of Care in Participants With Previously Treated Multiple Myeloma

NCT07555938Multiple Myeloma

DrugsCevostamab·Elotuzumab·Carfilzomib·Pomalidomide

Hoffmann-La Roche

Phase 3

380

California, Connecticut, District of Columbia, Georgia, North Carolina, Ohio, Texas, West Virginia

2026-06-23

Recruiting

The Effect of Remote Electrical Neuromodulation (REN) on Conditioned Pain Modulation (CPM) in Migraine and Fibromyalgia

NCT07841509Migraine, Fibromyalgia, Conditioned Pain Modulation

Theranica

Not applicable

120

New Jersey

2026-06-23

Recruiting

A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes

NCT07668388Diabetes Mellitus, Type 2

DrugsUBT251·Semaglutide

Novo Nordisk A/S

Phase 2

300

Alabama, California, Florida, Indiana, Kansas, Maryland, North Carolina, North Dakota

2026-06-22

Recruiting

A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Orally Administered TIX100 in Healthy Subjects

NCT07675590Health Adult Subjects, Obesity & Overweight

TIXiMED, Inc.

Phase 1

California

2026-06-22

Recruiting

A Study of ARC-02 in B-cell NHL

NCT07691606B-cell Non Hodgkin Lymphoma

DrugRituximab

Taiho Oncology, Inc.

Phase 1

140

California, Kentucky, North Carolina, Virginia, Washington, Wisconsin

2026-06-22

Recruiting

A Clinical Trial of MK-1045 and Rituximab in People With Follicular Lymphoma (MK-1045-007)

NCT07634471Follicular Lymphoma

DrugsRituximab Biosimilar·MK-1045·Riabni·Ruxience

Merck Sharp & Dohme LLC

Phase 2/3

960

California, Kentucky, New Jersey, New York, North Carolina, Ohio, Tennessee

2026-06-22

By invitation

An Evaluation of the Long-Term Safety and Efficacy of TSND-201 for the Treatment of PTSD

NCT07670702Post Traumatic Stress Disorder

DrugMethylone

Transcend Therapeutics

Phase 3

300

Arkansas, California, Colorado, Florida, Massachusetts, Missouri, New Jersey, Ohio

2026-06-22

Active, closed

Real-World Effectiveness of RSV Vaccines Among Adults Using Target Trial Emulation in Epic Cosmos

NCT07673081Respiratory Syncytial Virus (RSV)

Pfizer

Observational

293,334

New York

2026-06-22

Recruiting

Study of the Shockwave Medical SkyRunner Carotid Intravascular Lithotripsy (IVL) System for the Treatment of Calcified Carotid Arteries Prior to Trans-Carotid Stenting (SKYWARD Trans-Carotid IDE [Investigational Device Exemption] Study)

NCT07062471Carotid Artery Calcification, Carotid Artery Diseases

Shockwave Medical, Inc.

Not applicable

185

Arkansas, California, District of Columbia, Florida, Illinois, Massachusetts, Michigan, Minnesota

2026-06-22

Recruiting

A Study Evaluating the Efficacy and Safety of Risvutatug Rezetecan in Participants With Advanced Sarcomas (EMBOLD Sarcoma-202)

NCT07602777Sarcoma

DrugsRis-Rez·G-Csf

GlaxoSmithKline

Phase 1/2

Utah

2026-06-22

Active, closed

ColoSeal™ ICD System Anastomotic Protection Pivotal Study

NCT07429110Rectal Cancer Surgery

Averto Medical, Inc.

Not applicable

250

Florida, Ohio, South Carolina, Tennessee, Utah

2026-06-19

Recruiting

Intervention to Help Orient Men to Excel (IN-HOME) Phase II Study

NCT07704060Caregivers, Community Health Workers, Knowledge, Attitude

KDH Research & Communication

Not applicable

360

Georgia

2026-06-19

Recruiting

A Study to Evaluate Safety and Clinical Activity of GSK5926371 in Adult Participants With Relapsed or Refractory B-NHL

NCT07607925Lymphoma, Non-Hodgkin

DrugGSK5926371

GlaxoSmithKline

Phase 1/2

Iowa, New York, Ohio

2026-06-19

Not yet open

Large Diameter ViSiGi LUX ™ Gastric Sizing and Calibration System

NCT07572058Gastric Surgery

Boehringer Labs LLC

Not applicable

California

2026-06-19

Active, closed

A Study to Assess the Efficacy, Safety and Tolerability of AT673 Co-administered With Semaglutide in Adult Participants With Type 2 Diabetes (T2D) and Overweight or Obesity

NCT07724340Adults With Overweight/Obesity and Type 2 Diabetes

Antag Therapeutics

Phase 2

150

Arizona, California, Florida, Georgia, Utah

2026-06-19

Recruiting

A Study to Evaluate Ibuprofen (IBU) 62.5 mg and Acetaminophen (APAP) 125 mg/5 ml in an Oral Liquid Suspension Fixed-Dose Combination Product in Children Aged 6 to 11 Years

NCT07632274Pain

HALEON

Phase 1

Utah

2026-06-19

Recruiting

A Phase 1 Study of 177Lu-IM-3050 in Participants With Advanced Cancer

NCT07505771Solid Malignancies

Immunome, Inc.

Phase 1

105

Alabama, California, Florida, Texas

2026-06-19

Active, closed

A Study of T-Cell Receptor Engineered Donor T Cells in Subjects Undergoing Allogeneic Peripheral Blood Stem Cell Transplantation

NCT07702578AML, MDS

DrugTSC-101

TScan Therapeutics, Inc.

Phase 3

310

Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Kansas

2026-06-18

Recruiting

Clinical Study of MK-4884 in Participants With Advanced or Metastatic Solid Tumors (MK-4884-001)

NCT07600749Malignant Neoplasm

Merck Sharp & Dohme LLC

Phase 1

120

Missouri, Texas

2026-06-18

Recruiting

A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7663498 Following Intravitreal Administration in Participants With Diabetic Retinopathy

NCT07588100Diabetic Retinopathy

Hoffmann-La Roche

Phase 1

California, Illinois, Ohio, Texas

2026-06-18

Recruiting

A Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents

NCT07348666Suicide, Mental Health Disorder, Anhedonia

Ksana Health

Not applicable

100

Oregon, Pennsylvania

2026-06-18

Recruiting

A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015)

NCT07554339Non-small Cell Lung Cancer

DrugsCalderasib·Durvalumab

Merck Sharp & Dohme LLC

Phase 3

310

Georgia, Illinois, Nebraska, New York, North Carolina, Virginia

2026-06-18

Recruiting

Establishing the Preliminary Utility of a Novel Pediatric Manual Mobile Standing Wheelchair

NCT07290556Spina Bifida

Optimal Mobility, Inc

Not applicable

Minnesota

2026-06-18

Recruiting

Impact of Two Iron Formulations on Iron Biomarkers and Quality of Life

NCT07156526Iron Deficiencies

Qualia Life Sciences

Not applicable

California

2026-06-18

Recruiting

NMT EasyFit Sensor and Cable

NCT07394140Neuromuscular Blockade Monitoring, NMT

GE Healthcare

Not applicable

California

2026-06-18

Recruiting

Efficacy of PP-01 in Mitigating Cannabis Withdrawal Symptoms in Adults With Cannabis Use Disorder

NCT07644052Cannabis Withdrawal

DrugNabilone

PleoPharma, Inc.

Phase 3

420

Arkansas, Connecticut, Florida, Georgia, Kentucky, Maryland, Nevada, New Jersey

2026-06-17

Recruiting

STEPS - Stress Training and Engagement Via Phone-Based Systems

NCT07639697Psychological Distress, Mindfulness Skills, Usability Satisfaction, Program Engagement

Equa Health

Not applicable

300

Pennsylvania

2026-06-17

Recruiting

A Study of [225Ac]Ac-AKY-2519 in Patients With Metastatic Castration-Resistant Prostate Cancer

NCT07581184Castration Resistant Metastatic Prostate Cancer, Prostate Cancer, mCRPC (Metastatic Castration-resistant Prostate Cancer), mCRPC

Aktis Oncology, Inc.

Phase 1

138

California, Florida, Kansas, Louisiana, Massachusetts, Michigan, Nebraska, Pennsylvania

2026-06-17

Recruiting

Anti-CD14 Treatment With IC14 in Hospitalized ARDS Patients

NCT06513949Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome, Acute Lung Injury, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)

DrugAtibuclimab

Implicit Bioscience

Phase 2

Washington

2026-06-17

Recruiting

A Proof-of-Concept Study to Evaluate Topical-Lingual Semaglutide in Adults With Obesity

NCT07728383Obesity & Overweight

Gila Therapeutics, Inc.

Phase 4

Minnesota

2026-06-17

Recruiting

A Study to Learn How Different Amounts of the Study Medicine Called PF-08103402 Are Tolerated and Act in the Body in Healthy Adults or Adults With Mild To-moderate Asthma

NCT07660731Healthy Volunteer Study, Healthy Adults, Healthy Participants, Asthma

DrugMidazolam

Pfizer

Phase 1

133

Connecticut

2026-06-17

Active, closed

A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia

NCT07477704Hypercholesterolemia

DrugsPraluent·Alirocumab

Regeneron Pharmaceuticals

Phase 2

438

Alabama, California, Florida, Georgia, Hawaii, Kentucky, Louisiana, Montana

2026-06-17

Recruiting

xDot Access Management System Early Feasibility Study

NCT07464353Vascular Closure Devices

xDot Medical, Inc

Not applicable

Illinois, Minnesota, Oklahoma, South Dakota, Wisconsin

2026-06-16

Recruiting

A Study With NVC-001 in Patients With LMNA-related Dilated Cardiomyopathy (SUNBEAM-LMNA)

NCT07606274LMNA-Related Dilated Cardiomyopathy

Nuevocor Pte. Ltd.

Phase 1/2

Alabama, California, Massachusetts, Michigan, Minnesota, Ohio, Texas

2026-06-16

Recruiting

Study of [177Lu]Lu-DWJ155 and [68Ga]Ga-DWJ155 in Patients With Solid Tumors

NCT07660055Breast Cancer, Non-small Cell Lung Cancer (NSCLC), Gastric/Gastroesophageal Junction (GEJ) Cancer, Bladder Cancer

Novartis Pharmaceuticals

Phase 1

156

Nebraska, New York

2026-06-16

Recruiting

A Study to Evaluate DJI136, a DLL3-targeted CAR-T Therapy

NCT07564401Extensive-stage Small Cell Lung Cancer (ES-SCLC)

Novartis Pharmaceuticals

Phase 1/2

Kentucky, Texas, Washington

2026-06-16

Recruiting

A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Pancreatic Cancer

NCT07644559Pancreatic Ductal Adenocarcinoma (PDAC), G12D Mutated KRAS

DrugsVS-7375·Cetuximab

Verastem, Inc.

Phase 2

185

California, Florida, Illinois, Maryland, Massachusetts, Michigan, Minnesota, Missouri

2026-06-16

Recruiting

Aglatimagene Besadenovec + Prodrug and Pembrolizumab vs Docetaxel for Stage IV Non-Squamous NSCLC Progressing on Pembrolizumab (AURORA)

NCT07660094Non-squamous, Non-Small Cell Lung Cancer

DrugsAglatimagene besadenovec·Valacyclovir·Docetaxel·Pembrolizumab

Candel Therapeutics, Inc.

Phase 3

500

New York

2026-06-15

Active, closed

Generic Drugs (Dapagliflozin and Saxagliptin) Treat Type 2 Diabetes Patients With Controlled Cancers

NCT07033585Type 2 Diabetes

DrugsFarxiga·Dapagliflozin

Han Xu, M.D., Ph.D., FAPCR, Medical Director,, IRB Chair

Phase 2/3

600

Maryland

2026-06-15

Recruiting

Study to Learn About Safety, Tolerability, and Immune Response of a Catch-up Pneumococcal Vaccine in Children and Adolescents

NCT07660198Pneumococcal Disease

DrugsPG4·20-valent pneumococcal conjugate vaccine

Pfizer

Phase 3

1,200

Alabama, California, Colorado, Florida, Idaho, Kentucky, Louisiana, Massachusetts

2026-06-15

Recruiting

Semaglutide Delivered Epi-Intradermally by Microarray Patch (VX-201) Versus Subcutaneous Administration in Healthy Overweight and Obese Participants

NCT07673900Overweight and/or Obesity

DrugsWegovy·Semaglutide

Terrestrial Bio, Inc.

Phase 1

Arizona

2026-06-15

Recruiting

A Study of GS-3242 in Combination With Lenacapavir Versus Biktarvy in Virologically Suppressed People With HIV-1

NCT07645287HIV-1-infection

DrugsGS-3242·B/F/TAF·Lenacapavir

Gilead Sciences

Phase 2

175

Arizona, California, Colorado, Florida, Georgia, Michigan, Missouri, New Jersey

2026-06-15

Not yet open

A Post Market Trial Assessing the Accuracy of Normal Mode Reading vs. ProScan Reading With the NaviCam SB System. This is a Comparison of Retrospectively Obtained Capsule Endoscopy Videos With a New AI Reading Tool; no New Interventions Will be Completed.

NCT07633847Small Bowel Bleeding

AnX Robotica Corp.

Observational

New York, Texas

2026-06-15

Recruiting

Radicle GI Health RAATM: A Study Assessing the Impact of Health and Wellness Products on Gastrointestinal-Related Quality of Life and Related Health Outcomes

NCT07653776Digestion-associated Quality of Life

Radicle Science

Not applicable

550

California

2026-06-15

Recruiting

Miro3D Wound Matrix for Treatment of Diabetic Foot Ulcers

NCT07632001Diabetic Foot Ulcers (DFUs), Diabetic Foot, Chronic Wounds

Reprise Biomedical, Inc.

Not applicable

180

Arizona, Florida, Massachusetts, Missouri, New York, Ohio, Oklahoma, Texas

2026-06-15

Not yet open

A Retrospective Review: Outcomes of the REFLECT™ System for Idiopathic Scoliosis

NCT07589023Idiopathic Scoliosis

Globus Medical Inc

Observational

100

New York

2026-06-15

Not yet open

NaviCam Patency Capsule to Verify Gastrointestinal Patency

NCT07649720Intestinal Stricture, Crohn Disease, NSAID (Non-Steroidal Anti-Inflammatory Drug) Induced Enteropathy, Abdominal Pain

AnX Robotica Corp.

Not applicable

Illinois

2026-06-15

Recruiting

Cantharidin Application in Patients With Common Warts (Verruca Vulgaris) (COVE-3)

NCT07637734Common Warts, Common Warts (Verruca Vulgaris), Human Papilloma Virus (HPV), Warts

Verrica Pharmaceuticals Inc.

Phase 3

300

California, Florida, Illinois, Kansas, Louisiana, Massachusetts, Minnesota, Nebraska

2026-06-15

Recruiting

A Phase IIIb Study to Evaluate Camizestrant Plus Ribociclib in ER-positive, HER2-negative Advanced Breast Cancer

NCT07647328ER-Positive HER2-Negative Breast Cancer

DrugsCamizestrant·Ribociclib

AstraZeneca

Phase 3

150

California, Georgia, Illinois, Kentucky, Nevada, South Dakota, Tennessee, Texas

2026-06-15

Not yet open

SpO2 Infant and Pediatric Study

NCT07615738SpO2 (Peripheral Oxygen Saturation) Measurement Validation, SpO2

GE Healthcare

Not applicable

180

Nebraska

2026-06-15

By invitation

Interference and Stability Evaluation of the Intelligent Fingerprinting Drug Screening System

NCT07758907Interference With Routine Analytical Tests, Stability of in Vitro Diagnostic Reagents, Illicit Drug Use

Intelligent Bio Solutions Inc.

Not applicable

New Jersey

2026-06-15

Not yet open

Virtual Activities of Living for Occupational Rehabilitation

NCT07450586Stroke, Occupational Therapy, Activities of Daily Living, Rehabilitation

Barron Associates, Inc.

Not applicable

North Carolina

2026-06-15

Recruiting

A Safety and Efficacy Study of EIK1001 in Combination With Pembrolizumab and Chemotherapy in Participants With Stage 4 Non-Small Cell Lung Cancer.

NCT07365319Non Small Cell Lung Cancer (Squamous or Non Squamous), Stage 4 NSCLC

DrugsEIK1001·Cisplatin/Carboplatin·Nab-paclitaxel·Pemetrexed

Eikon Therapeutics

Phase 2/3

750

Alabama, California, Colorado, Florida, Illinois, New Mexico, New York, Tennessee

2026-06-15

Recruiting

IGNITE: Study of Tirabrutinib vs Rituximab and Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL)

NCT07104032Relapsed/Refractory Primary Central Nervous System Lymphoma

DrugsTirabrutinib·Temozolomide·Rituximab

Ono Pharmaceutical Co., Ltd.

Phase 3

132

Arizona, California, Connecticut, District of Columbia, Florida, Maryland, Massachusetts, Minnesota

2026-06-12

Recruiting

A Study of Treatment Patterns and Outcomes in Gastroenteropancreatic Neuroendocrine Tumor (GEP-NET) Patients

NCT07635316Gastroenteropancreatic Neuroendocrine Tumor

Novartis Pharmaceuticals

Observational

4,023

New Jersey

2026-06-12

Recruiting

A Study to Assess Real-World Use and Outcomes of TAR-200 for Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) in the United States

NCT07309445Non-Muscle Invasive Bladder Neoplasms

Janssen Research & Development, LLC

Observational

150

Alabama, Arizona, Arkansas, California, Colorado, Florida, Illinois, Indiana

2026-06-12

Recruiting

Open Label Extension to Assess Long Term Safety and Efficacy of KL1333 in Patients With Primary Mitochondrial Disease

NCT07514338Mitochondrial Diseases

DrugNapazimone

Pharming Technologies B.V.

Phase 2

140

Ohio

2026-06-12

Active, closed

A Phase 2 Study to Evaluate the Pharmacodynamics, Safety and Tolerability of BGE-102 in Participants With Obesity and Cardiovascular Risk Factors

NCT07656727Obesity and Cardiovascular Risk

DrugBGE-102

BioAge Labs, Inc.

Phase 2

160

Arizona, Arkansas, Florida, Kentucky, Maryland, Missouri, Nevada, New York

2026-06-11

Recruiting

Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold (RMS) System in Subjects With Coronary Artery Lesions

NCT07258290Coronary Disease, Heart Diseases, Cardiovascular Diseases, Arteriosclerosis

Teleflex

Not applicable

1,859

District of Columbia, West Virginia

2026-06-11

Not yet open

Cell Free Preimplantation Genetic Testing

NCT04628507Infertility, Female, Infertility, Male

Genomic Prediction Inc.

Observational

200

New Jersey

2026-06-11

Recruiting

Testing of GripTract-GI Endoscopic Tissue Manipulator for Use During Complex Endoscopic Polypectomies in the Colon

NCT06015607Polyps Colorectal

Actuated Medical, Inc.

Not applicable

Ohio

2026-06-11

Recruiting

A Study of TAK-360 in People With Narcolepsy or Idiopathic Hypersomnia

NCT07646678Idiopathic Hypersomnia, Narcolepsy Type 1, Narcolepsy Type 2

DrugTAK-360

Takeda

Phase 2/3

500

California, Colorado, Florida, Georgia, Maryland, Michigan, Missouri, New Jersey

2026-06-11

Recruiting

A Trial Evaluating AMG 127 in Healthy Participants and Participants With Type 2 Diabetes Mellitus

NCT07590193Diabetes Mellitus, Type 2

Amgen

Phase 1

162

California, Florida

2026-06-11

Recruiting

A Phase 2 Study of NT-101 Topical in Patients With Wet AMD

NCT07811726Wet Age Related Macular Degeneration

NexThera Co., Ltd.

Phase 2

Florida, Oklahoma, Pennsylvania

2026-06-11

Recruiting

Efficacy and Safety of Novosis Putty in Transforaminal Lumbar Interbody Fusion for Patients With Lumbar Degenerative Disc Disease

NCT07017634Degenerative Disc Disease

CGBio Inc.

Phase 3

316

Arkansas, California, Florida, Louisiana, Ohio, Pennsylvania, Texas, West Virginia

2026-06-11

Recruiting

Study Comparing Avance Nerve Graft and Autograft for Functional Recovery Following Mixed and Motor Peripheral Nerve Reconstruction

NCT07657182Peripheral Nerve Injury, Peripheral Nerve Discontinuity, Mixed Peripheral Nerve Injury, Motor Peripheral Nerve Injury

Axogen Corporation

Phase 4

178

Florida, Indiana, Missouri

2026-06-11

Recruiting

A Phase IIb Study to Evaluate AZD8965 in Participants With IPF.

NCT07652658Idiopathic Pulmonary Fibrosis (IPF)

AstraZeneca

Phase 2

359

Alabama, Arizona, California, Colorado, Florida, Georgia, Idaho, Illinois

2026-06-11

Active, closed

A Study to Evaluate the Efficacy and Safety of Concomitant Use of Eplontersen and ALXN2220 Compared With Eplontersen and Placebo for Adults Participants With ATTR-CM

NCT07608354Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

DrugsCliramitug·Eplontersen

AstraZeneca

Phase 2

326

California, Colorado, District of Columbia, Florida, Illinois, Massachusetts, Missouri, New York

2026-06-11

Recruiting

A Study to Assess Efficacy and Safety of Efgartigimod PH20 SC PFS in Adult Participants With Graves' Disease

NCT07570316Graves' Disease, Graves Disease

DrugEfgartigimod PH20

argenx

Phase 3

230

California, Florida, Kansas, Michigan, Missouri, New York, North Carolina, Texas

2026-06-10

Recruiting

A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity

NCT07595549Obesity, Overweight and/or Obesity, Overweight

DrugBerobenatide

Pfizer

Phase 3

954

California, Florida, Illinois, Indiana, Kentucky, Maryland, Michigan, Nebraska

2026-06-10

Recruiting

Supporting Weak Immune System During Autoimmune Therapy: Testing Panzyga to Prevent Infections

NCT07220915Hypogammaglobulinemia, Autoimmune Conditions, Rheumatic Conditions, Infections

DrugPanzyga

Octapharma

Phase 3

360

Arizona, Missouri, Tennessee, Texas

2026-06-10

Recruiting

Evaluation of YB-101 for Safety, Tolerability, Pharmacokinetics, and Efficacy in Graves' Disease

NCT07682896Graves' Disease

Yarrow Bioscience, Inc.

Phase 2

232

Arizona, California, Florida, Georgia, Kentucky, Michigan, Nebraska, New York

2026-06-10

Active, closed

A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With Obesity

NCT07639021Obesity

DrugsNNC0662-0419·Semaglutide

Novo Nordisk A/S

Phase 2

233

Alabama, California, Florida, Illinois, Indiana, Kentucky, Maryland, Missouri

2026-06-09

Recruiting

Assessment of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a New Formulation of Inclisiran Containing Polysorbate 80 Compared to the Currently Marketed Formulation

NCT07626281Inclisiran Formulation

DrugInclisiran

Novartis Pharmaceuticals

Phase 1

152

Kansas, Texas, Utah

2026-06-09

Recruiting

Health Ahead Comparative Effectiveness Study

NCT07669168Health Services Accessibility, Rural Health, Medically Underserved Area, Preventive Health Services

William Brandenburg, MD

Not applicable

1,000,000

Colorado

2026-06-09

Recruiting

Efficacy and Safety Study of TPX-115 on Partial-thickness Rotator Cuff Tear

NCT07219654Partial Thickness Rotator Cuff Tears

DrugTPX-115

Tego Science, Inc.

Phase 2

California, Florida, Illinois

2026-06-09

Recruiting

D07001 Softgel-Capsules and Capecitabine Combination Therapy in Patients With Advanced Biliary Tract Cancer

NCT06622057Biliary Tract Cancer (BTC)

InnoPharmax Inc.

Phase 3

240

Arizona, Florida, Ohio, Texas

2026-06-09

Recruiting

Optimizing Extended-Duration (XD-) TOMAC Therapy for Restless Legs Syndrome (RLS)

NCT07675109Restless Legs Syndrome (RLS)

Noctrix Health, Inc.

Not applicable

California

2026-06-08

Recruiting

An Open-label Study of NNZ-2591 in Pediatric Participants With Phelan-McDermid Syndrome

NCT07593391Phelan-McDermid Syndrome

DrugNNZ-2591

Neuren Pharmaceuticals Limited

Phase 3

180

Alabama, California, Illinois, Maryland, Massachusetts, New York, Ohio, Texas

2026-06-08

By invitation

Long-term Safety and Efficacy of Multiple Long-acting Antibodies Alone and in Combinations for IBD

NCT07652294Ulcerative Colitis, Inflammatory Bowel Diseases, Colitis, Colitis, Ulcerative

DrugsSPY001·SPY002·SPY003

Spyre Therapeutics, Inc.

Phase 2

645

California, Florida, Louisiana, Minnesota, Rhode Island, Texas, Washington

2026-06-08

Recruiting

Pivotal Open-label Phase 3 Clinical Study of QTX-2101 in Adult Patients With Acute Promyelocytic Leukemia

NCT07504458Acute Promyelocytic Leukemia (APL), Acute Promyelocytic Leukaemia, Acute Promyelocytic Leukemia With PML-RARA, Acute Promyelocytic Leukemia With t(15;17)(q24.1;q21.2); PML-RARA

DrugsArsenic Trioxide·ATRA

Quetzal Therapeutics

Phase 3

150

Alabama, California, Georgia, Kentucky, Maryland, Michigan, New York, North Carolina

2026-06-08

Recruiting

Study of GB-4362 With Enfortumab Vedotin and Pembrolizumab for Advanced Urothelial Cancer

NCT07484022Advanced Urothelial Cancer, Metastatic Urothelial Carcinoma

DrugsEnfortumab Vedotin·Pembrolizumab

Generate Biomedicines

Phase 1

California, Florida, Georgia, Illinois, New Jersey, New York, Texas, Virginia

2026-06-08

Recruiting

A Study to Compare the Steady-State Bioavailability of Injectable Letrozole SIE and Oral Letrozole in Post-Menopausal Women With Hormone Receptor Positive Early Breast Cancer

NCT07401381Hormone Receptor Positive Early Breast Cancer

Rovi Pharmaceuticals Laboratories

Phase 1

120

California, Florida

2026-06-08

Active, closed

A Study to Evaluate the Effect of Carbamazepine or Itraconazole on Radiprodil in Healthy Adult Participants

NCT07884734Healthy Adult Participants

DrugsRadiprodil·Carbamazepine·Itraconazole

GRIN Therapeutics, Inc.

Phase 1

California

2026-06-08

Recruiting

A Study of Investigational RSV/hMPV Combination and Investigational hMPV Vaccines in Younger and Older Adults

NCT07628049Respiratory Syncytial Virus Infections+Metapneumovirus

GlaxoSmithKline

Phase 1/2

1,456

Georgia, Kansas, Washington

2026-06-05

Recruiting

A Study to Evaluate the Efficacy, Safety, Pharmacodynamics (PD), and Pharmacokinetics (PK) of Selnoflast in Reducing Vascular Inflammation in Participants With Atherosclerosis at Risk for Major Adverse Cardiac Events

NCT07448038Atherosclerosis

Genentech, Inc.

Phase 2

162

California, Connecticut, Florida, Indiana, Michigan, Minnesota, Missouri, Nebraska

2026-06-05

Recruiting

Water Vapor Ablation for Prostate Cancer: Long-Term Registry

NCT07455058Prostate Cancer

Francis Medical Inc.

Observational

2,500

Louisiana, Minnesota, Texas, Virginia

2026-06-05

By invitation

Long-term Safety and Efficacy Evaluation of IMG-007 in Participants With Moderate-to-Severe Atopic Dermatitis

NCT07734415Atopic Dermatitis, Atopic Dermatitis Eczema, Eczema

DrugIMG-007

Inmagene LLC

Phase 2

400

California, Florida, Illinois, New York, North Carolina, North Dakota, Ohio, Oregon

2026-06-05

Active, closed

Open-Label Extension Study of BBP-418 (Ribitol) for LGMD2I/R9

NCT07678775Limb-Girdle Muscular Dystrophy Type 2I (LGMD2I)

DrugRibitol

ML Bio Solutions, Inc.

Phase 3

107

Arkansas, California, Colorado, Florida, Iowa, Kansas, Maryland, Minnesota

2026-06-05

Recruiting

Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma

NCT07562152Pancreatic Cancer, Pancreatic Cancer Metastatic, PDAC, PDAC - Pancreatic Ductal Adenocarcinoma

Immuneering Corporation

Phase 3

570

Alabama, Arizona, California, Colorado, Delaware, Florida, Georgia, Illinois

2026-06-05

Recruiting

Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1

NCT07563881Focal Seizure, Epilepsy, Focal Epilepsy

DrugRAP-219

Rapport Therapeutics Inc.

Phase 3

333

Alabama, California, Florida, Georgia, Idaho, Illinois, Indiana, Maryland

2026-06-05

Active, closed

Kosmos Guidance Performance Evaluation Data Annotation

NCT07771270Heart, Ultrasound, Cardiac Ultrasound, Cardiac Disease

EchoNous Inc.

Observational

Washington

2026-06-05

Recruiting

Risk of Progressive Multifocal Leukoencephalopathy Among Patients With Multiple Sclerosis Exposed to Zeposia

NCT07732907Multiple Sclerosis, Progressive Multifocal Leukoencephalopathy

DrugOzanimod

Bristol-Myers Squibb

Observational

New Jersey

2026-06-04

Recruiting

A Study to Assess How Intravenous and Subcutaneous Administrations of Risankizumab Moves Through the Body of Healthy Adult Participants

NCT07466550Healthy Volunteer

DrugRisankizumab

AbbVie

Phase 1

California, Florida

2026-06-04

Recruiting

A Study of Lirafugratinib in Non-CCA Solid Tumors With FGFR2 Fusion or Rearrangement

NCT07359820FGFR2 Gene Fusion/Rearrangement, Other Solid Tumors, Adult

Elevar Therapeutics

Phase 2

Arizona, Florida, Illinois, Massachusetts, Minnesota, New York, Texas

2026-06-04

Recruiting

A Study to Investigate Mocertatug Rezetecan Compared With Chemotherapy in Participants With Endometrial Cancer After Platinum-based Chemotherapy and Immunotherapy (BEHOLD-Endometrial01)

NCT07286331Neoplasms, Endometrial

DrugsMocertatug rezetecan·Doxorubicin·Paclitaxel

GlaxoSmithKline

Phase 3

600

Alabama, Nebraska, Texas, Virginia

2026-06-04

Recruiting

Evaluation of a Non-Invasive Device for Early Detection of Atopic Dermatitis Flares

NCT07645820Atopic Dermatitis

Castle Biosciences Incorporated

Observational

450

Arizona, California, Maryland, Michigan, Missouri, Nevada, New Hampshire, Texas

2026-06-04

Recruiting

MAVRiC Studies 2L Treatment With AV in Patients With CLL/SLL Who Have Relapsed After a Course of BTKi + BCL2i Combination, With or Without Obinutuzumab

NCT07024706Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL)

DrugsAcalabrutinib·Venclexta·Venetoclax

AstraZeneca

Phase 2

Massachusetts, North Carolina

2026-06-04

Recruiting

A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations

NCT07629960Advanced Solid Tumor, Non-Small Cell Lung Cancer, Colorectal Neoplasms, Pancreatic Ductal Adenocarcinoma

Blueprint Medicines Corporation

Phase 1/2

265

Florida, Louisiana, Massachusetts, Michigan, New Jersey, New York, Tennessee, Texas

2026-06-04

Recruiting

A Study of TAK-360 in Adults With Narcolepsy Type 1 (Narcolepsy With Cataplexy)

NCT07633301Narcolepsy Type 1

DrugTAK-360

Takeda

Phase 2

California, Florida, Ohio

2026-06-04

Recruiting

A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With Narcolepsy

NCT07675135EDS, Cataplexy, Fatigue, Narcolepsy

DrugPitolisant

Harmony Biosciences Management, Inc.

Phase 3

258

Alabama, Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana

2026-06-04

Recruiting

Biweekly Long-term Occidiofungin Study for Suppression of Mycotic Recurrence

NCT07521137Candidiasis, Vulvovaginal

Sano Chemicals Inc

Phase 2

Alabama

2026-06-04

Recruiting

A Study to Learn About Heart-Related Risks in Elderly Men With Advanced Prostate Cancer Treated With Enzalutamide or Darolutamide

NCT07672119Prostate Cancer

Bayer

Observational

3,000

New Jersey

2026-06-04

Recruiting

Anifrolumab Pregnancy Study

NCT07049653Systemic Lupus Erythematosus

AstraZeneca

Observational

500

North Carolina

2026-06-04

Recruiting

Large Algorithm Setting and Validation Study

NCT07607470Bacterial Infections, Bacterial Infections and Mycoses, Infections, Vaginitis

Nanopath, Inc

Observational

1,000

Florida, Louisiana

2026-06-03

Recruiting

A Study to Evaluate D-2570 in Participants With Moderate to Severe Plaque Psoriasis

NCT07489885Psoriasis

DrugD-2570

InventisBio Co., Ltd

Phase 2

Alabama, Arizona, California, Florida, Georgia, Idaho, Indiana, Kentucky

2026-06-03

Recruiting

Randomized Single Center Study to Evaluate Tolerability, Symptoms, and Visual Functional Outcomes With the Use of OTC Lubricating Eye Drops in Subjects With Dry Eye Disease

NCT07676084Dry Eye Disease (DED)

Andover Research Eye Institute

Phase 4

Massachusetts

2026-06-03

Recruiting

An Extension Study to Assess Long-Term Safety and Efficacy of Afimkibart in Participants With Rheumatoid Arthritis

NCT07620392Rheumatoid Arthritis

DrugAfimkibart

Hoffmann-La Roche

Phase 2

120

Florida, Louisiana, Texas, Wisconsin

2026-06-03

Recruiting

Food and Metabolism Study

NCT07624500Prediabetes, Insulin Resistance, Triglycerides, Lipids Metabolism

Clinical Nutrition Research Center, Illinois Institute of Technology

Not applicable

Illinois

2026-06-03

Recruiting

Study to Evaluate the Safety of Retreatment With Restylane® Lyft With Lidocaine for Augmentation of the Chin Region

NCT07566286Chin Augmentation

Galderma R&D

Not applicable

100

Connecticut, Florida, Georgia, Maryland, Tennessee, Texas

2026-06-03

Active, closed

Collection of Training Data for LuminX Probe AI Models

NCT07565480Data Collection for AI Training of Dental Prob

LuminX

Not applicable

150

California, Florida, Tennessee

2026-06-03

Recruiting

Study of ALK-001 on the Progression of Stargardt Disease

NCT07419334Stargardt Disease

DrugALK-001

Alkeus Pharmaceuticals, Inc.

Phase 3

230

Arizona, Colorado, Florida, Massachusetts, Michigan, Ohio, Pennsylvania, Texas

2026-06-03

Recruiting

Phase Ib/II Platform Study of Multiple Anti-Cancer Agents in Participants With Metastatic Prostate Cancer

NCT07590934Metastatic Prostate Cancer

DrugsAZD2287·FPI-2265·Palacaparib·Docetaxel

AstraZeneca

Phase 1/2

152

California, Florida, Louisiana, Minnesota, Nebraska, New York, Oregon, Texas

2026-06-03

Recruiting

A Study to Evaluate the Efficacy of NIO752 in Participants With Progressive Supranuclear Palsy

NCT07498426Progressive Supranuclear Palsy Richardson Syndrome (PSP-RS)

Novartis Pharmaceuticals

Phase 3

300

Arizona, California, Colorado, Florida, Kentucky, Louisiana, Minnesota, Texas

2026-06-03

Recruiting

A Study to Evaluate Efficacy and Safety of YSBP Compared to Lumigan in Patients With Glaucoma or Ocular Hypertension

NCT07661329Primary Open Angle Glaucoma (POAG), Ocular Hypertension (OH)

YS Life Science Co., Ltd.

Phase 3

600

California, Florida, Georgia, Kentucky, Missouri, Texas

2026-06-02

Recruiting

A Study of WIN378 in Participants With Moderate to Severe COPD (Sirius)

NCT07646587COPD (Chronic Obstructive Pulmonary Disease)

DrugWIN378

Windward Bio

Phase 2

105

California, Florida, Massachusetts, North Carolina, Oregon, Pennsylvania, Texas

2026-06-02

Recruiting

Study of GS-2426 in Participants With Advanced Solid Tumors

NCT07601243Advanced Solid Tumors

Gilead Sciences

Phase 1

174

Massachusetts, Michigan, New Jersey, New York, Texas

2026-06-02

Recruiting

An Efficacy and Safety Study of Cenegermin Ophthalmic Solution Compared With Vehicle in the Treatment of PCED

NCT07519902Persistent Corneal Epithelial Defect

DrugCenegermin

Dompé Farmaceutici S.p.A

Phase 3

150

California, Florida, Massachusetts, Michigan, Missouri, New York, North Carolina, South Dakota

2026-06-02

Recruiting

Ixoberogene Soroparvovec (Ixo-vec) Contralateral Dosing Study in Participants With Neovascular Age-related Macular Degeneration

NCT07630649Neovascular Age-Related Macular Degeneration (nAMD) Wet AMD

Adverum Biotechnologies, Inc.

Phase 2

Arizona, California, Florida, Hawaii, Illinois, New Jersey, South Carolina, Texas

2026-06-02

Recruiting

A Prospective Cohort Study of Basivertebral Nerve Ablation Using the Stryker OptaBlate BVN System for the Treatment of Vertebrogenic Low Back Pain

NCT07392333Verteborgenic Low Back Pain, Back Pain Lower Back

Stryker Instruments

Observational

Florida

2026-06-02

Recruiting

Method Comparison of Intelligent Fingerprinting Drug Screening System

NCT07650136Drug Abuse Illicit

Intelligent Bio Solutions Inc.

Observational

144

New Jersey

2026-06-02

Recruiting

A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk

NCT07613294Atherosclerosis, Cardiovascular Diseases, Lipoprotein(a)

DrugLepodisiran

Eli Lilly and Company

Phase 3

252

California, Florida, Idaho, Massachusetts, Michigan, Nevada, Pennsylvania, Utah

2026-06-01

Recruiting

PROspect Registry :Post Market Clinical Follow-up Study

NCT07631468Breast Surgery

Stryker Endoscopy

Observational

5,000

Florida, Massachusetts

2026-06-01

Recruiting

Paclitaxel-Coated Balloon Treatment of Chronic Rhinosinusitis

NCT07290140Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps

Airiver Medical, Inc.

Not applicable

300

Alabama, California, Colorado, Iowa, Kansas, Kentucky, New York, Pennsylvania

2026-06-01

Not yet open

A System to Help With Freezing of Gait in Parkinson's Patients

NCT07542743Freezing of Gait Symptoms in Parkinson Disease

Barron Associates, Inc.

Not applicable

Virginia

2026-06-01

Recruiting

A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction

NCT07192952Left Ventricular Systolic Dysfunction, Heart Failure (Pediatric)

DrugFinerenone

Bayer

Phase 3

117

Colorado, Delaware, Florida, Georgia, Indiana, Massachusetts, Michigan, Missouri

2026-06-01

Active, closed

A Clinical Trial to Evaluate the Effects of a Fibre Supplement on Microbiome and Gut Health

NCT07781488Gut Health, Microbiome, Bloating, Indigestion

Artah Nutrition Limited

Not applicable

Nevada

2026-06-01

Recruiting

DB-3Q for the Treatment of Medically Refractory Crohn's Disease

NCT07625293Crohn Disease (CD)

DrugDB-3Q

Direct Biologics, LLC

Phase 2

Missouri

2026-06-01

Recruiting

First-in-human Study of a New Treatment (4A10) for Patients With Relapsed or Hard-to-treat Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma, Focused on Safety and How the Drug Behaves in the Body and Early Signs of Effect.

NCT07586618Lymphoblastic Lymphoma, Acute Lymphoblastic Leukemia ALL

Allterum Therapeutics, Inc

Phase 1

Colorado, Indiana, New York, Ohio, Pennsylvania, Texas

2026-06-01

Recruiting

L19IL2 or L19TNF or L19IL2/TNF in Patients With Basal Cell Carcinoma (BCC)

NCT07227350Locally Advanced Basal Cell Carcinoma

DrugsDaromun·L19IL2·Onfekafusp alfa

Philogen S.p.A.

Phase 2

180

Florida, Georgia, North Carolina, Ohio, Texas

2026-06-01

Not yet open

Evaluation of the Efficacy, Safety, and Tolerability of LevoCept

NCT04457076Contraception, Women at Risk for Pregnancy

Sebela Women's Health Inc.

Phase 3

1,525

California, Colorado, Georgia, Hawaii, Indiana, Minnesota, Missouri, Nevada

2026-06-01

Recruiting

A Study of CDX-622 in Participants With Mild to Moderate Asthma

NCT07330778Mild to Moderate Asthma

Celldex Therapeutics

Phase 1

California, Kansas, Massachusetts, Pennsylvania

2026-06-01

Recruiting

Surabgene Lomparvovec Administered in the Suprachoroidal Space in Adult Participants With Diabetic Retinopathy Without Center-Involved Diabetic Macular Edema

NCT07592273Diabetic Retinopathy

DrugSurabgene Lomparvovec

AbbVie

Phase 2/3

576

Arizona, California, Colorado, Florida, Georgia, Illinois, Kansas, Maine

2026-06-01

Recruiting

CREST: Samphire Guided Care Program on Wellbeing, Work Productivity, and Quality of Life

NCT07679074Premenstrual Syndrome, Premenstrual Dysphoric Disorder, Dysmenorrhea, Endometriosis

Samphire Group, Inc.

Observational

California

2026-06-01

Recruiting

A Study to Evaluate Safety, Tolerability and Efficacy of AP306 at Fixed Doses in Dialysis Participants With Hyperphosphatemia

NCT06712654Hyperphosphatemia, Chronic Kidney Disease Requiring Chronic Dialysis, End Stage Renal Disease on Dialysis

R1 Therapeutics

Phase 2

168

Alabama, California, Colorado, Connecticut, Florida, Georgia, Michigan, Minnesota

2026-06-01

Not yet open

Decision Counseling and Follow-up for Shield+ Patients

NCT07620535Colo-rectal Cancer

Guardant Health, Inc.

Observational

350

Pennsylvania

2026-06

Recruiting

Efficacy, Safety, and Tolerability of Zeleciment Rostudirsen (DYNE-251) Administered Intravenously Every 4 Weeks in Ambulatory Participants With Duchenne Muscular Dystrophy (FORZETTO)

NCT07608432Duchenne Muscular Dystrophy (DMD), Muscular Dystrophy, Duchenne, Muscular Dystrophy (DMD), DMD

DrugZeleciment Rostudirsen

Dyne Therapeutics

Phase 3

North Carolina

2026-06

Not yet open

A Study to Evaluate ANS014004 in Combination With EGFR-TKI in Non-Small Cell Lung Cancer

NCT07285148Non-Small Cell Lung Cancer, EGFR Mutation, Metastatic Lung Cancer, MET Alteration

DrugsANS014004·Andamertinib·Osimertinib

Beijing Pearl Biotechnology Limited Liability Company

Phase 1/2

253

New York

2026-06

Not yet open

Exploring Acne Treatments Through Clinical Research Participation

NCT07010458Acne

Power Life Sciences Inc.

Observational

500

California

2026-06

Recruiting

Novel Self-charging, Medical-Grade Smart Insoles With AI/ML Edge Computing to Monitor Biometrics.

NCT07273422No Applicable Condition; Study of Physiologic Monitor Alarms

Spectrum Ergonomics and Occupational Health Services

Observational

150

Pennsylvania

2026-06

Recruiting

The Pharmacokinetics and Pharmacodynamics Study of Evategrel CG-0255 Besylate）and Plavix® in Healthy Participants

NCT07619885Acute Coronary Syndromes (ACS), Recent Myocardial Infarction, Recent Stroke, Peripheral Arterial Disease

DrugClopidogrel

Shanghai CureGene Pharmaceutical Co., Ltd.

Phase 1

136

Florida

2026-06

Not yet open

A Study of CS231295 in Patients With Advanced Solid Tumors

NCT07612488Advance Solid Tumors, Advanced Malignant Solid Tumors

ThalassaX Therapeutics United States Ltd

Phase 1

Colorado, Florida, Massachusetts, Tennessee

2026-06

Not yet open

A First-in-human Study of 3HP-2827 in Patients With Unresectable or Metastatic Solid Tumors With FGFR2 Alterations

NCT06287918Solid Tumors With FGFR2 Alterations, Adult

Drug3HP-2827

3H (Suzhou) Pharmaceuticals Co., Ltd.

Phase 1

130

Arizona, Texas

2026-06

Not yet open

GraftAssure Lowering Allograft rejeCTIon by Combination- (GALACTIC) Trial

NCT07551531Kidney Transplant

Insight Molecular Diagnostics

Observational

5,000

New Jersey

2026-06

Not yet open

SCI-110 in the Treatment of Tourette Syndrome

NCT05126888Tourette Syndrome

Neurothera Labs Inc.

Phase 2

164

Connecticut

2026-06

Recruiting

Bi-lateral HGN Therapy in Real-World Patients -Post Approval Research Investigation

NCT07331285Obstructive Sleep Apnea

Nyxoah Inc.

Observational

229

Florida, New Jersey

2026-06

Not yet open

Serene Sleep Palatal Implant System Clinical Confirmatory Trial in Participants Who Snore or Are Diagnosed With Mild-to-moderate Obstructive Sleep Apnea (OSA).

NCT07613281Snoring, OSA - Obstructive Sleep Apnea

Serene Sleep, Inc.

Not applicable

California, Georgia

2026-06

Not yet open

Mitral Valve Repair With the Chord-X System: A Long Term Evaluation

NCT07413926Mitral Regurgitation (MR)

Artivion Inc.

Observational

110

Kentucky

2026-06

Recruiting

A Study Comparing JNJ-79635322 and Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

NCT07518186Multiple Myeloma

DrugsRamantamig·Teclistamab

Janssen Research & Development, LLC

Phase 3

700

Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia

2026-05-31

Not yet open

Validation of a Body-Composition Segmentation Software on a Diverse Public CT Scan Cohort

NCT07600866Sarcopenia, Body Composition, Obesity

Nucleo Research, Inc.

Observational

200

California

2026-05-31

Recruiting

A Study to Learn About How a New Pneumococcal Vaccine Works in Infants.

NCT07629440Pneumococcal Disease

DrugsPG4·20-valent pneumococcal conjugate vaccine

Pfizer

Phase 3

3,230

Alabama, Arkansas, California, Colorado, Florida, Georgia, Idaho, Illinois

2026-05-29

Recruiting

NORM-HF Pivotal Study

NCT07574593Heart Failure, NYHA Class III Heart Failure, NYHA Class II Heart Failure

Foundry Innovation & Research 1, Limited (FIRE1)

Not applicable

800

California, Florida, Louisiana, Massachusetts, Missouri, Nebraska, New York, North Carolina

2026-05-29

Recruiting

A Phase 1 Study of D3S-003 as Monotherapy in Participants With Advanced Solid Tumors With a KRAS p.G12D Mutation.

NCT07456046KRAS P.G12D

D3 Bio (Wuxi) Co., Ltd

Phase 1

Connecticut, Texas

2026-05-29

Recruiting

Evaluation of the Tolerability of Cagrilintide in Participants Not Tolerating GLP-1-RA Therapies Due to Gastrointestinal Adverse Events

NCT07607587Obesity, Overweight

DrugCagrilintide

Novo Nordisk A/S

Phase 1

114

California, Florida, Georgia, North Carolina, South Carolina, Tennessee, Texas

2026-05-29

Recruiting

A Study to Assess the Safety and Pharmacokinetics of INCB123667 When Administered Orally to Adult Participants With Severe Renal Impairment or End Stage Renal Disease

NCT07559396Renal Impairment

DrugINCB123667

Incyte Corporation

Phase 1

Florida

2026-05-29

Recruiting

Immune Modulation During Palynziq® Treatment in Adults (IMPALA)

NCT07477691Phenylketonuria

DrugsPegvaliase·Methotrexate

BioMarin Pharmaceutical

Phase 4

California, Colorado, Florida, Illinois, Indiana, Minnesota, New York, Oregon

2026-05-29

Recruiting

A Study to Learn About How Safe BAY3389934 is and How it Affects Blood Clotting When Given Alone or With Aspirin in Healthy Participants

NCT07652723Drug-drug Interaction

DrugsBAY3389934·Aspirin

Bayer

Phase 1

Florida

2026-05-29

Recruiting

A Study to Evaluate the Pharmacodynamics of a Combination of QCZ484 and Inclisiran in Participants With Hypertension and Concomitant Hypercholesterolemia

NCT07610278Hypercholesterolaemia

DrugsQCZ484·Inclisiran

Novartis Pharmaceuticals

Phase 2

120

Alabama, California, Florida, Georgia, Illinois, Kansas, Louisiana, Maryland

2026-05-29

Recruiting

Efficacy and Safety of Intravesical TARA-002 Compared With Investigator's Choice of Intravesical Chemotherapy in Participants With BCG-naïve High-grade Non-muscle Invasive Bladder Cancer

NCT07480356Bladder (Urothelial, Transitional Cell) Cancer, Non-Muscle Invasive Bladder Carcinoma, Non-muscle Invasive Bladder Cancer With Carcinoma in Situ

DrugTARA-002

Protara Therapeutics

Phase 3

284

Arizona, Arkansas, California, Georgia, Missouri, South Carolina, Texas

2026-05-29

Recruiting

A Study to Investigate the Effects of Cleminorexton Compared With Placebo in the Treatment of Participants With Central Disorders of Hypersomnolence

NCT07598708Narcolepsy Type 1, Narcolepsy Type 2

Centessa Pharmaceuticals (UK) Limited

Phase 2/3

222

Alabama, Colorado, Florida, Georgia, Michigan, Mississippi, North Carolina, Ohio

2026-05-29

By invitation

Shortwave Infrared Surgical Imaging Device Study

NCT07744425Cholecystitis, Cholecystitis, Chronic, Chronic Calculous Cholecystitis, Primary Hyperparathyroidism

Cision Vision, Inc.

Observational

California, Illinois, Maryland

2026-05-29

Recruiting

Study of IEV407 as Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast Cancer

NCT07604571Advanced HR+/HER2- Breast Cancer

DrugsLetrozole·Fulvestrant

Novartis Pharmaceuticals

Phase 1

194

Connecticut, Kansas, Texas

2026-05-28

Recruiting

A Phase 2 Safety, Tolerability, PK, and Efficacy Study of CS-1103 Following Fentanyl Challenge With Naloxone Blockade

NCT07459166Fentanyl Overdose, Fentanyl Poisoning

DrugsCS-1103·Naloxone Hydrochloride·Fentanyl

Clear Scientific, Inc.

Phase 2

California

2026-05-28

Recruiting

A Phase 2b Study of the Effects of Camoteskimab in Adults With Moderate-to-Severe Atopic Dermatitis

NCT07599813Atopic Dermatitis, Atopic, Dermatitis, Dermatitis, Atopic

Apollo Therapeutics Ltd

Phase 2

280

Alabama, Arizona, Arkansas, California, Colorado, Florida, Georgia, Idaho

2026-05-28

Recruiting

Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HT31-1 for Treating ARDS

NCT07449572ARDS (Acute Respiratory Distress Syndrome)

HTIC, Inc

Phase 1

Virginia

2026-05-28

Recruiting

A Study of MACI in Patients Aged 17 to 65 Years With Symptomatic Chondral or Osteochondral Defects of the Ankle

NCT06915233Chondral Defect, Articular Cartilage Defect

Vericel Corporation

Phase 3

309

Arizona, California, Colorado, District of Columbia, Kansas, Minnesota, North Carolina, Pennsylvania

2026-05-28

Recruiting

A Study to Evaluate a New Semi-rigid Brace, the RESILIENT Brace by Thinks Works, as a Way to Limit Curve Worsening in Kids With Idiopathic Scoliosis.

NCT07574632Idiopathic Scoliosis

Thinks Works, PBC

Not applicable

Delaware

2026-05-28

Recruiting

Open-label Study of SKY-GJB2 in Pediatric Subjects With GJB2-mediated Hearing Loss

NCT07627971GJB2-mediated Hearing Loss, GJB2 Gene Mutation, DFNB1A

Skylark Bio Inc.

Phase 1/2

Maryland, Massachusetts, Oklahoma, Pennsylvania

2026-05-28

Recruiting

A Study to Learn About the Safety of Taking an Additional Dose of the Medicine Rimegepant in Adults With Migraine

NCT07609914Acute Treatment of Migraine

DrugRimegepant

Pfizer

Phase 4

400

California, Florida, Illinois, Indiana, Massachusetts, Michigan, Minnesota, Mississippi

2026-05-28

Recruiting

A Phase 2A Clinical Trial to Assess the Safety and Tolerability of ERX1000 in Men and Women for the Treatment of Obesity.

NCT07570758Obesity & Overweight

ERX Pharmaceuticals

Phase 2

Kentucky, North Carolina, South Carolina

2026-05-28

Recruiting

A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )

NCT07101328Lymphoma, Non-Hodgkin, B-cell Lymphoma, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular

Eli Lilly and Company

Phase 1

215

California, Colorado, Connecticut, Illinois, Iowa, Kansas, Massachusetts, Michigan

2026-05-28

Recruiting

Privosegtor Investigation in Optic Neuropathies Efficacy Evaluation Research

NCT07623668Optic Neuritis

DrugMethylprednisolone

Oculis

Phase 3

210

Michigan, South Carolina, Texas

2026-05-28

Recruiting

A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions and Subcutaneous Injections of ABBV-519 in Adult Participants With Systemic Lupus Erythematosus (SLE) or Rheumatoid Arthritis (RA)

NCT07607964Systemic Lupus Erythematosus, Rheumatoid Arthritis

AbbVie

Phase 1

Alabama, California, Florida, Illinois, Tennessee, Texas

2026-05-28

Recruiting

A Study of How the Medicine Called "Etrasimod" Works in Children With the Gut Disease Called Ulcerative Colitis

NCT07470879Colitis, Ulcerative

DrugEtrasimod

Pfizer

Phase 2

Indiana, New York

2026-05-28

Recruiting

A Phase 1 Study of the Safety and Tolerability of CTX-10726

NCT07419841Gastroesophageal Cancer (GC), Hepatocellular Carcinoma (HCC), Endometrial Cancer, Renal Cell Carcinoma (RCC)

Compass Therapeutics

Phase 1

Arizona, Florida, Minnesota, Nebraska, New York, Pennsylvania, South Carolina, Tennessee

2026-05-28

Recruiting

A Study to Assess the Safety and Pharmacokinetics of INCB123667 When Administered Orally to Adult Participants With Moderate or Severe Hepatic Impairment

NCT07559474Hepatic Insufficiency, Liver Diseases

DrugINCB123667

Incyte Corporation

Phase 1

Arizona, Florida, Texas

2026-05-27

Recruiting

Post-Market Clinical Study Using TRAQ™ for Minimally Invasive Posterior Sacroiliac Joint Fusion

NCT07547215Sacroiliac Joint Dysfunction, Sacroiliac Joint Pain

PainTEQ, LLC

Observational

100

Arizona

2026-05-27

Recruiting

A Phase 3 Study of Pelabresib (DAK539) and Ruxolitinib in Myelofibrosis (MF)

NCT07357727Primary Myelofibrosis (PMF), Post-polycythemia Vera Myelofibrosis (PPV-MF), Post-essential Thrombocythemia Myelofibrosis (PET-MF)

DrugsPelabresib·Ruxolitinib

Novartis Pharmaceuticals

Phase 3

460

Colorado, Connecticut, Florida, Georgia, Illinois, Indiana, Maryland, New Jersey

2026-05-27

Recruiting

Evaluation of the Pharmacokinetics, Biodistribution and Radiation Dosimetry of [18F]MODAG-009 Positron Emission Tomography (PET) Radiotracers in Adult Healthy Volunteers

NCT07617688Healthy Adult

Drug[¹⁸F]MODAG-009 PET Imaging

MODAG GmbH

Early Phase 1

Connecticut

2026-05-27

Recruiting

A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA® HD (Aflibercept) in Participants With Neovascular Age-related Macular Degeneration

NCT07614776Neovascular Age-related Macular Degeneration, nAMD

Amgen

Phase 3

304

California, Colorado, Connecticut, Florida, Illinois, Indiana, Maryland, Massachusetts

2026-05-27

Recruiting

A Study to Evaluate the Efficacy and Safety of Rozanolixizumab in Adult Participants With Ocular Myasthenia Gravis

NCT07463521Ocular Myasthenia Gravis

DrugRozanolixizumab

UCB Biopharma SRL

Phase 3

120

Arizona, Illinois, New York, Ohio, Wisconsin

2026-05-27

Recruiting

A Study to Investigate the Safety and Efficacy of KQB368 as Monotherapy in Participants With Advanced Solid Malignancies

NCT07542704Advanced Solid Tumors, Colorectal Cancer (CRC), Non-Small Cell Lung Cancer, Uterine Cancer

Kumquat Biosciences Inc.

Phase 1

California, Massachusetts, Michigan, New Jersey, New York, Ohio, Oregon, Pennsylvania

2026-05-27

Recruiting

Tensi+ for Treating Overactive Bladder

NCT07300904Overactive Bladder (OAB)

Stimuli Technology

Not applicable

California, New York

2026-05-26

Recruiting

Clareon TruPlus Study

NCT07502456Aphakia, Astigmatism

Alcon Research

Not applicable

185

Arizona, Ohio, South Carolina, Texas, Utah

2026-05-26

Recruiting

Phase 1 Study Evaluating Safety and Pharmacokinetics of ASY202 in Adults With Asthma

NCT07665892Safety in Asthma Patients

Aspeya, Inc.

Phase 1

Arizona, California, Texas

2026-05-26

Recruiting

A Clinical Trial to Evaluate agenT-797 Plus Standard of Care in Participants With Severe Pneumonia With Moderate to Severe Acute Hypoxemic Respiratory Failure

NCT07615010Pneumonia

MiNK Therapeutics

Phase 2

California, Texas

2026-05-26

By invitation

Evaluate the Efficacy of an Oral Health Behavioral Intervention in People With Diabetes

NCT07619729Diabetes Type 2, Periodontal Disease, Caries

DrugStannous Fluoride Dentifrice

Colgate Palmolive

Phase 4

10,000

New York

2026-05-26

Recruiting

The Impact of Enhanced Music & Natural Visuals on Emotional Health

NCT07676110Emotion Management Skills, Lifestyle, Healthy, Lifestyle Intervention, Recovery

soundBrilliance LLC

Not applicable

200

Colorado, Nebraska, Nevada

2026-05-25

Recruiting

Intratumoral N17350 in Advanced Solid Tumors

NCT07339176Neoplasms, Solid Tumor, Breast Neoplasms, Triple-Negative, Squamous Cell Carcinoma of Skin, Melanoma

Onchilles Pharma Inc

Phase 1/2

275

California, New York, Texas

2026-05-25

Recruiting

Safety Evaluation of MODI, an Insulin Titration Algorithm, in Adults With Diabetes

NCT07599982Type 1 Diabetes (T1D), Type 2 Diabetes (T2D)

DreaMed Diabetes

Not applicable

102

Maryland, Michigan, New York, North Carolina, Texas, Utah

2026-05-25

By invitation

A Phase 3 Study Evaluating the Safety and Efficacy of TRIESENCE® (Injectable Suspension) for the Treatment of Ocular Inflammation and Pain After Ophthalmic Surgery

NCT07832552Postoperative Ocular Inflammation, Postoperative Ocular Pain

Harrow Inc

Phase 3

250

Missouri

2026-05-25

Recruiting

A Study to Investigate the Safety and Tolerability of Oral INR731 Single Agent or in Combination With Androgen Receptor Pathway Inhibitor (ARPI) in Patients With Metastatic Prostate Cancer

NCT07570979Metastatic Castration-resistant Prostate Cancer (mCRPC)

DrugsAbiraterone·Enzalutamide

Novartis Pharmaceuticals

Phase 1

208

Massachusetts, Texas

2026-05-25

Recruiting

INTREPID: A Study of Sapablursen Evaluating the Safety and Efficacy in Participants With Polycythemia Vera (PV)

NCT07429266Polycythemia Vera

Ono Pharmaceutical Co., Ltd.

Phase 3

250

California, Florida, Georgia, Maryland, Michigan, New York, Ohio, Pennsylvania

2026-05-25

Recruiting

A Study to Compare the PK Characteristics, Safety, Tolerability, and Immunogenicity of HLX15-SC With DARZALEX FASPRO® in Combination With Lenalidomide and Dexamethasone (Rd) in Transplant-ineligible Patients With Newly Diagnosed Multiple Myeloma

NCT07477587Multiple Myeloma (MM)

Shanghai Henlius Biotech

Phase 1

258

Arkansas, Florida, Indiana, Louisiana, Texas, Washington

2026-05-25

Recruiting

A Study of JNJ-78934804 in Participants With Moderately to Severely Active Ulcerative Colitis

NCT07577856Colitis, Ulcerative

DrugsJNJ-78934804·Tremfya·Guselkumab

Janssen Research & Development, LLC

Phase 3

644

Arizona, California, Colorado, Florida, Georgia, Kentucky, Louisiana, Missouri

2026-05-23

Recruiting

First-in-Human Trial to Assess REGN20423 in Healthy Adult Participants and Adult Participants With Atopic Dermatitis

NCT07527923Healthy Volunteer, Atopic Dermatitis

Regeneron Pharmaceuticals

Phase 1

160

Alabama, Arkansas, California, Florida, Georgia, South Carolina, Texas

2026-05-22

Recruiting

A Study to Access Intravenous (IV) Telisotuzumab Adizutecan in Combination With IV Bevacizumab Compared to Standard of Care IV Bevacizumabin Combination With Oral Trifluridine and Tipiracil in Adult Participants With Refractory Metastatic Colorectal Cancer

NCT07525206Colorectal Cancer

DrugsTelisotuzumab Adizutecan·Trifluridine/Tipiracil·Bevacizumab

AbbVie

Phase 3

990

Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia, Illinois

2026-05-22

Recruiting

A Phase 2a Study of ALN-PNP With and Without a GLP1R Agonist in Adult Patients With Homozygous PNPLA3-Related MASLD

NCT07527910Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

DrugsAln-Pnp·Tirzepatide

Regeneron Pharmaceuticals

Phase 2

204

Arizona, California, Florida, Louisiana, Texas

2026-05-22

Recruiting

Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of Investigator's Choice as First-line Treatment in Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma ( RASolute 305 )

NCT07621718Pancreatic Cancer, Pancreatic Cancer Metastatic, PDAC, PDAC - Pancreatic Ductal Adenocarcinoma

DrugsZoldonrasib·Leucovorin·Irinotecan·Adrucil

Revolution Medicines, Inc.

Phase 3

670

Arizona, Connecticut, Florida, Georgia, Illinois, Maryland, Massachusetts, Minnesota

2026-05-22

Recruiting

Multi-Center, Prospective, Non-Interventional Study in Subjects With Limbal Stem Cell Deficiency

NCT07636590Limbal Stem Cell Deficiency

Claris Biotherapeutics, Inc.

Observational

500

Indiana, Kansas, Kentucky, Minnesota, Oregon, Tennessee, Texas

2026-05-22

Recruiting

A Study of JNJ-78934804 in Participants With Moderately to Severely Active Crohn's Disease

NCT07577843Crohn Disease

DrugsJNJ-78934804·Tremfya·Guselkumab

Janssen Research & Development, LLC

Phase 3

460

Arizona, California, Colorado, Florida, Georgia, Kentucky, Louisiana, Missouri

2026-05-22

Active, closed

Study Evaluating the Efficacy of KITE-753 Versus Axicabtagene Ciloleucel in Participants With Relapsed or Refractory Large B-Cell Lymphoma After First-Line Therapy

NCT07479797Relapsed or Refractory Large B-cell Lymphoma

DrugsKITE-753·Axicabtagene Ciloleucel·Fludarabine·Cyclophosphamide

Kite, A Gilead Company

Phase 3

550

Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Maryland

2026-05-22

Recruiting

A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).

NCT07602582Alzheimer Disease, Dementia, Plaque, Amyloid

DrugDonanemab

Eli Lilly and Company

Phase 3

550

Arizona, California, Florida, Georgia, Idaho, Illinois, Indiana, Iowa

2026-05-22

Recruiting

BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease

NCT07492641HR+/HER2- Breast Cancer

DrugsBGB-43395·Ribociclib·Abemaciclib·Palbociclib

BeOne Medicines

Phase 3

1,056

Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Florida

2026-05-22

Not yet open

Retrospective Kinetic Safety Evaluation of an Intravenous Micellar Excipient Platform

NCT07609069Drug Related Side Effects and Adverse Reactions, Infusion Reactions

PICO IV, Inc.

Observational

625

California

2026-05-21

Recruiting

A Study of Rebecsinib for Patients With Relapsed/Refractory Secondary Acute Myeloid Leukemia or High Risk Myelofibrosis

NCT07250646Secondary AML, Myelofibrosis

Aspera Biomedicines, Inc.

Phase 1

California

2026-05-21

Recruiting

Study of PM54 in Combination With Immunotherapy in Adult Participants With Advanced Malignancies

NCT07644039Advanced Malignancies

DrugsPM54·Pembrolizumab

PharmaMar

Phase 1/2

119

New York, Texas, Virginia

2026-05-21

Recruiting

Trial of Ureteroscopy vs Steerable Continuous Flow Aspiration Technology

NCT07101809Urolithiasis, Stones, Kidney, Renal Stones, Kidney Stones

Calyxo, Inc.

Not applicable

150

Alabama, Florida, New York, Ohio, Pennsylvania, Texas

2026-05-21

Recruiting

A Phase 1, First-in-human Study of VX-433

NCT07584434Narcolepsy Type 1 (NT1)

DrugsBupropion·Midazolam

Vertex Pharmaceuticals Incorporated

Phase 1

118

Utah

2026-05-21

Recruiting

A Relative Bioavailability and Bioequivalence Study of Varegacestat in Healthy Participants

NCT07610005Healthy

Immunome, Inc.

Phase 1

Arizona

2026-05-21

Recruiting

A Study of Zanzalintinib in Participants With Recurrent or Progressive Meningioma

NCT07428616Meningioma

DrugZanzalintinib

Exelixis

Phase 2

100

Alabama, Arizona, California, Florida, Illinois, Louisiana, Massachusetts, Minnesota

2026-05-21

Recruiting

A Phase 1 Study of IM-1617 in Participants With Advanced Cancer

NCT07578571Colorectal Cancer, Non-Small Cell Lung Cancer, Breast Cancer, Esophageal Cancer

Immunome, Inc.

Phase 1

200

Connecticut, Florida, Massachusetts, Texas

2026-05-21

Recruiting

A Study of LY3439539 in Participants With Alzheimer's Disease

NCT07598370Alzheimer Disease

Eli Lilly and Company

Phase 1

California, Florida, Michigan

2026-05-21

Recruiting

ASCEND: Safety and Tolerability of ION337 for the Treatment of Dravet Syndrome

NCT07531745Dravet Syndrome

Ionis Pharmaceuticals, Inc.

Phase 1/2

Michigan, Minnesota, North Carolina, Pennsylvania, Tennessee, Washington

2026-05-21

Recruiting

RO7771950 Versus Tucatinib in Combination With Trastuzumab and Capecitabine in People With Locally Advanced or Metastatic Breast Cancer That is Human Epidermal Growth Factor Receptor 2 (HER2)-Positive

NCT07413939HER2-positive Breast Cancer

DrugsZN-A-1041·Tucatinib·Trastuzumab·Capecitabine

Hoffmann-La Roche

Phase 2/3

650

Alabama, Arizona, California, Connecticut, Michigan, New Jersey, New York, Tennessee

2026-05-21

Recruiting

A Study to Compare Linvoseltamab and Daratumumab Treatment in High-Risk Smoldering Multiple Myeloma (HR-SMM)

NCT07393282High Risk Smoldering Multiple Myeloma (HR-SMM)

DrugsLinvoseltamab·Darzalex·Daratumumab

Regeneron Pharmaceuticals

Phase 3

270

Arizona, Georgia, Massachusetts, Michigan, Minnesota, Missouri, New York, Ohio

2026-05-21

Recruiting

A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Lower Risk Myelodysplastic Syndromes (LR-MDS) Who Need Regular Blood Transfusions

NCT07422480Myelodysplastic Syndrome, Anemia

DrugsElritercept·Epoetin Alfa

Takeda

Phase 3

300

Arizona, California, Connecticut, Florida, Georgia, Idaho, Illinois, Kentucky

2026-05-21

Recruiting

A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight

NCT07564414Obesity, Type 2 Diabetes

DrugsCagriSema·Semaglutide

Novo Nordisk A/S

Phase 3

2,500

Alabama, Arizona, Arkansas, California, Colorado, Florida, Georgia, Idaho

2026-05-21

Recruiting

Mathematical Modeling of Blood Sugar and Hormone Responses in Insulin-Dependent Type 2 Diabetes

NCT07650682Type 2 Diabetes, Insulin Dependent Diabetes

Clinical Nutrition Research Center, Illinois Institute of Technology

Observational

Illinois

2026-05-20

Recruiting

A Study to Assess Adverse Events and How Intravenous (IV) Pivekimab Sunirine Moves Through the Body in Pediatric Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML)

NCT07306832Acute Myeloid Leukemia

DrugPivekimab Sunirine

AbbVie

Phase 1

California, Georgia, New York, Tennessee, Texas

2026-05-20

Recruiting

Phase 3 Study of LUM-201 in Children With Growth Hormone Deficiency

NCT06948214Growth Hormone Deficiency (GHD)

DrugLUM-201

Lumos Pharma

Phase 3

150

Alabama, California, Colorado, District of Columbia, Florida, Georgia, Indiana, Iowa

2026-05-20

Recruiting

Phase 1/2 Study of UI-102 in Selected Advanced Cancers

NCT07605962Advanced Cancer

United Immunity, co., Ltd.

Phase 1/2

140

Texas

2026-05-20

Recruiting

A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)

NCT07589595Cognitive Dysfunction, Lewy Body Disease, Synucleinopathies, Amyloid

DrugDonanemab

Eli Lilly and Company

Phase 2

350

Arizona, California, Colorado, Connecticut, Florida, Indiana, Kansas, Massachusetts

2026-05-20

Not yet open

AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight

NCT07400107Obesity, Overweight, Diabetes Mellitus, Type 2

DrugsNNC0487-0111·Semaglutide

Novo Nordisk A/S

Phase 3

1,000

Florida, Georgia, Idaho, Maryland, Michigan, Texas, Virginia

2026-05-20

Recruiting

A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256)

NCT07124078Chronic Graft-versus-host-disease

DrugAxatilimab

Incyte Corporation

Phase 2

California, District of Columbia, Florida, Georgia, New York, North Carolina, Pennsylvania, Washington

2026-05-20

Recruiting

ALTO-207 in Adults With Treatment-resistant Depression (TRD)

NCT07553637Treatment-resistant Depression (TRD)

Alto Neuroscience

Phase 2

178

Alabama, Arizona, California, Connecticut, Florida, Georgia, Illinois, Indiana

2026-05-20

Recruiting

A Study of Zunveyl on Safety, Tolerability, Neuropsychiatric Symptoms, and Caregiver Distress in Alzheimer's Disease (RESOLVE)

NCT07633470Alzheimer Disease

Alpha Cognition, Inc

Phase 4

150

California, Florida, Georgia, Illinois, Indiana, Massachusetts, Michigan, Missouri

2026-05-20

Recruiting

Crownlands Observing Progression With Neurons Study

NCT07611396Alzheimer s Disease, Mild Cognitive Impairment (MCI)

Crownlands

Observational

160

Maryland

2026-05-19

Recruiting

Efficacy of Qualia Testosterone+ on Testosterone Levels in Adult Males

NCT07556458Low Testosterone Levels

Qualia Life Sciences

Not applicable

California

2026-05-19

Recruiting

Study Evaluating the Efficacy, Safety, and Tolerability of ASY202 (Dihydroergotamine Mesylate [DHE] Inhalation Powder Delivered Via a Multidose Dry Powder Inhaler) for the Acute Treatment of Migraine in Adult Patients

NCT07646613Migraine

Aspeya, Inc.

Phase 2

108

Arizona, California, Connecticut, Florida, Georgia, Massachusetts, Missouri, Nevada

2026-05-19

By invitation

ID-ENTITY Trial- Evaluating Serial T-ID Monitoring

NCT07393594Kidney Diseases, Kidney Injury, BK Virus Infection, CMV

Transplant Genomics, Inc.

Observational

1,000

Arizona, California, Kansas, Michigan, New Hampshire, New Jersey, New York, North Carolina

2026-05-19

Recruiting

A Study of JADE101 in Participants With Immunoglobulin A Nephropathy

NCT07541287IgA Nephropathy

DrugJADE101

Jade Biosciences, Inc.

Phase 2

California, Colorado, Florida, Texas

2026-05-19

Recruiting

Study of Denikitug (GS-1811) Given Alone or With Nivolumab or With Chemotherapy in Adults With Advanced Colorectal Cancer

NCT07527858Advanced Microsatellite Stable Colorectal Cancer

DrugsDenikitug·Trifluridine/Tipiracil·Nivolumab·Bevacizumab

Gilead Sciences

Phase 2

170

Connecticut, Massachusetts, Missouri, South Dakota, Virginia

2026-05-19

Recruiting

Study to Evaluate HM15275 in Subjects With Type 2 Diabetes Mellitus

NCT07527650Type 2 Diabetes Mellitus, T2DM

DrugHM15275

Hanmi Pharmaceutical Company Limited

Phase 2

180

Arizona, California, Florida, Georgia, Illinois, Indiana, Missouri, Nebraska

2026-05-18

Recruiting

Study of [212Pb]Pb-DOTAM-MAM279 ([212Pb]Pb-MP0712) in Patients With Small Cell Lung Cancer and Other DLL3 Expressing Solid Tumors

NCT07278479Large Cell Neuroendocrine Carcinoma, Large Cell Pulmonary Neuroendocrine Carcinoma of the Lung (LCNEC), Extrapulmonary Neuroendocrine Carcinoma (EP-NEC), Small Cell Lung Cancer (SCLC)

Molecular Partners AG

Phase 1/2

138

Florida, Georgia, Illinois, Maryland, Nebraska, New Jersey, Ohio, Texas

2026-05-18

Recruiting

First-in-Human Study to Evaluate AZD8359 STEAP2 TCE in Participants With Prostate Cancer

NCT07529717Metastatic Prostate Cancer

AstraZeneca

Phase 1/2

Florida, New Jersey, Rhode Island

2026-05-18

Recruiting

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Clinical Activity of ABS-1230 in Pediatric and Young Adult Participants With KCNT1-related Epilepsy

NCT07600736KCNT1-Related Epilepsy

DrugABS-1230

Actio Biosciences, Inc.

Phase 2

New Jersey, New York

2026-05-18

Recruiting

A Study of JNJ-1761981 in Participants With Solid Tumors

NCT07525141Neoplasms

DrugCetrelimab

Johnson & Johnson Enterprise Innovation Inc.

Phase 1

Florida, Minnesota, New York, Texas

2026-05-18

Recruiting

A Study of CSTI-500 in Patients With Prader-Willi Syndrome

NCT07348601Prader-Willi Syndrome

ConSynance Therapeutics

Phase 2

Tennessee

2026-05-18

Recruiting

Evaluation of Gixam's Efficacy Predicting the Presence of Advanced and Non-advanced Colorectal Neoplasia in a FIT Negative Population

NCT07623902CRC Screening, Microbiome

Jubaan Ltd.

Not applicable

1,436

Alabama, California, Florida, Illinois, New York, Ohio, Virginia

2026-05-18

Recruiting

A Study of TAK-755 in Adults With Acute Ischemic Stroke

NCT07392450Acute Ischemic Stroke

DrugTAK-755

Takeda

Phase 2

222

Arizona, California, Massachusetts, New York, Pennsylvania, Tennessee, Texas

2026-05-17

Recruiting

PKP2-ACM Natural History Study

NCT06644742Cardiomyopathies, Heart Diseases, Cardiovascular Diseases, Genetic Diseases

Rocket Pharmaceuticals Inc.

Observational

Massachusetts, North Carolina

2026-05-15

Recruiting

A Clinical Study to Evaluate the Effects of NXT007 Compared to Factor VIII Prophylaxis in Participants With Hemophilia A

NCT07416526Hemophilia A

Hoffmann-La Roche

Phase 3

138

Colorado, Iowa

2026-05-15

Recruiting

A Study to Assess the Safety and Effects of ABBV-1758 Following Subcutaneous or Intravenous Injections in Participants With Alzheimer's Disease

NCT07599670Alzheimer's Disease

AbbVie

Phase 1/2

210

California, Colorado, Florida, Massachusetts, Tennessee, Texas

2026-05-15

Recruiting

Technology Assisted Treatment for Trichotillomania

NCT05118633Trichotillomania

HabitAware Inc.

Not applicable

Ohio

2026-05-15

Recruiting

A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

NCT07589608Overweight, Obesity

DrugsMacupatide·Eloralintide

Eli Lilly and Company

Phase 2

400

Arizona, California, Connecticut, Florida, Idaho, Illinois, Kansas, Kentucky

2026-05-15

Recruiting

A Study to Assess How Well and Safely Elafibranor Works in Adult Participants With Primary Sclerosing Cholangitis

NCT07387549Primary Sclerosing Cholangitis

DrugElafibranor

Ipsen

Phase 3

350

Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois

2026-05-14

Recruiting

A Study to Investigate the Safety and PK of VH4770359 in Healthy Participants

NCT07525544HIV Infections

DrugMidazolam

ViiV Healthcare

Phase 1

214

Maryland

2026-05-14

Recruiting

A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers

NCT07598136Smoking, Tobacco

RAI Services Company

Not applicable

1,280

Florida, Georgia, Missouri, North Carolina, Pennsylvania, Texas

2026-05-14

Recruiting

A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression

NCT07610473Major Depressive Disorder (MDD)

DrugDT-101

Draig Therapeutics Ltd

Phase 2

118

Arizona, Arkansas, California, Florida, Georgia, Illinois, Massachusetts, New York

2026-05-14

Recruiting

AtraUmatic Laparoscopic HerNia Repair Clinical Investigation to Evaluate the Safety and Performance of The ECLIPSIUM System for Mesh Fixation IDE

NCT07277946Hernia

Tissium

Not applicable

240

California, Florida, Illinois, Kentucky, Michigan, Nebraska, North Carolina, Ohio

2026-05-14

Recruiting

A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated

NCT07553429Diabetic Macular Edema

Boehringer Ingelheim

Phase 1/2

Arizona, California, Connecticut, Florida, New York, North Carolina, North Dakota, Ohio

2026-05-14

Recruiting

Efficacy, Safety, and Tolerability of Zeleciment Basivarsen (DYNE-101) in Participants With Myotonic Dystrophy Type 1

NCT07486934Myotonic Dystrophy Type 1 (DM1), DM1, Myotonic Dystrophy, Steinert Disease

DrugZeleciment basivarsen

Dyne Therapeutics

Phase 3

150

California, Florida, Georgia, Indiana, Maryland, Missouri, New York, North Carolina

2026-05-14

Recruiting

Evaluation of the Efficacy of Hyalomatrix® in the Healing of Chronic Venous Leg Ulcers

NCT07335861Venous Leg Ulcer, Chronic Wounds

NuScience Medical Biologics, LLC

Not applicable

122

Louisiana, Mississippi

2026-05-14

Recruiting

IS-001 Injection in Patients Undergoing Robotic-Assisted Colorectal Surgery

NCT07346066Ureter Injury

Intuitive Surgical

Phase 3

146

California, Connecticut, Florida, Nevada, Ohio, Texas, Washington

2026-05-14

Recruiting

Symbiotic-GI-16: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer

NCT07392892Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction , or Esophageal Adenocarcinoma, Metastatic Gastric Cancer, Gastroesophageal Junction Cancer, Esophageal Adenocarcinoma

DrugsPF-08634404·Nivolumab

Pfizer

Phase 2/3

840

California, Colorado, Florida, Illinois, Maryland, Nevada, New Jersey, New York

2026-05-14

Recruiting

A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer

NCT07287098Breast Neoplasms

DrugsImlunestrant·Goserelin·Tamoxifen

Eli Lilly and Company

Phase 2

600

Alabama, Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana

2026-05-13

Recruiting

A Study of JNJ-95804306 for Relapsed or Refractory Hematological Malignancies

NCT07572006Hematologic Neoplasms

Janssen Research & Development, LLC

Phase 1

320

Indiana, Michigan, New Jersey, New York, Tennessee, Texas

2026-05-13

Recruiting

iDose TR Administration in an Office-Based Surgery Setting

NCT07816692Open Angle Glaucoma (OAG), Ocular Hypertension (OHT)

Glaukos Corporation

Observational

Texas

2026-05-13

Recruiting

A Study to Investigate Efficacy and Safety of KP-001 Compared With Placebo in Patients Aged ≥2 Years With Common VM, Common LM, or KTS/CLOVES Syndrome

NCT07285005Venous Malformations, Lymphatic Malformations, Klippel-Trenaunay Syndrome, CLOVES Syndrome

Kaken Pharmaceutical

Phase 3

150

South Carolina

2026-05-13

Recruiting

Study of NMS-03305293 in Adult Patients With Relapsed Ovarian Cancer

NCT06930755Ovarian Cancer

DrugsNMS-03305293·Topotecan

Nerviano Medical Sciences

Phase 1

Illinois, Missouri, Pennsylvania, Tennessee, Texas

2026-05-13

Recruiting

Efficacy of the Omnipod® 6 System Compared With the Omnipod® 5 System

NCT07579702Type 2 Diabetes Mellitus, Type 1 Diabetes Mellitus

Insulet Corporation

Not applicable

200

California, Colorado, Connecticut, Georgia, Illinois, Indiana, Massachusetts, Michigan

2026-05-13

Active, closed

A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis

NCT07501702Myasthenia Gravis, Generalized

DrugPovetacicept

Vertex Pharmaceuticals Incorporated

Phase 2

California, Florida, Georgia, Hawaii, Illinois, Nevada, North Carolina, South Carolina

2026-05-13

Recruiting

Evaluation of [¹⁸F]MODAG-009 PET Imaging in Synucleinopathies

NCT07640555Multiple System Atrophy (MSA), Healthy Adult, Parkinson Disease

Drug[¹⁸F]MODAG-009 PET Imaging

MODAG GmbH

Early Phase 1

Connecticut

2026-05-13

Recruiting

Wearable Photoplethysmography for Non-invasive Hydration Assessment

NCT07520344Hydration Status

PepsiCo Global R&D

Not applicable

Texas

2026-05-12

Recruiting

CAPTURE-2: Controlled Arterial Protection to Ultimately Remove Embolic Material

NCT07276711Aortic Valve Stenosis, Aortic Stenosis, Aortic Valve Disease

EmStop Inc

Not applicable

663

California, Florida, Louisiana, Michigan, North Carolina, South Dakota, Texas

2026-05-12

Recruiting

A Long-term Follow-up Study of Patients With ARD103 CAR-T Cell Therapies

NCT06906380Acute Myeloid Leukemia, in Relapse, Acute Myeloid Leukemia, in Relapsed or Refractory, MDS (Myelodysplastic Syndrome)

ARCE Therapeutics, Inc.

Observational

North Carolina, Texas

2026-05-12

Recruiting

An Exploratory Efficacy and Safety Study of DFL24498 Topical Ophthalmic Solution Compared With Vehicle in Participants With Dry Eye Disease

NCT07503886Dry Eye Disease (DED)

DrugDFL24498

Dompé Farmaceutici S.p.A

Phase 2

417

Arizona, California, Florida, Georgia, Indiana, Minnesota, Missouri, North Carolina

2026-05-12

Recruiting

A Study to Assess the Safety, Tolerability and Efficacy of ION775

NCT07604974Hypertriglyceridemia, Severe Hypertriglyceridemia

Ionis Pharmaceuticals, Inc.

Phase 2

California, Colorado, Florida, Georgia, Indiana, Kentucky, Michigan, Ohio

2026-05-12

Recruiting

Effect of the Amplifi™ Vein Dilation System on Outflow Vein Dilation and AV Fistula Maturation (AMPLIFI-1)

NCT07211035End Stage Kidney Disease (ESRD)

Amplifi Vascular, Inc.

Not applicable

160

Massachusetts, Texas

2026-05-12

Recruiting

A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of DNL952 in Adult Participants With Late-Onset Pompe Disease

NCT07354724Late-onset Pompe Disease

Denali Therapeutics Inc.

Phase 1

California, Missouri, North Carolina, Virginia

2026-05-12

Recruiting

An Evaluation of Long-Term Supplement Use on Biological Age and Metabolic Health Markers - The BioAge Trial

NCT07755943Generally Healthy Adults Who Are Long-term Supplement Users

Shaklee Corporation

Observational

300

Illinois

2026-05-12

Recruiting

Sarilumab Efficacy and Safety in Adults With Early Polymyalgia Rheumatica

NCT07286214Polymyalgia Rheumatica

DrugSarilumab

Sanofi

Phase 3

300

Arizona, California, Colorado, Florida, Georgia, Illinois, Maryland, Minnesota

2026-05-12

Recruiting

Evaluate the Safety and Feasibility of Same-Day Bilateral Epithelium-On Corneal Cross-Linking for Keratoconus

NCT07629557Keratoconus

Glaukos Corporation

Phase 4

Ohio

2026-05-11

Recruiting

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

NCT07567001Obesity, Heart Failure

DrugNNC0487-0111

Novo Nordisk A/S

Phase 3

5,610

Alabama, Arizona, Arkansas, California, Colorado, District of Columbia, Florida, Georgia

2026-05-11

Active, closed

A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity

NCT07575932Overweight, Obesity, Overweight and/or Obesity, Overweight or Obesity

DrugsPF-08653945·Berobenatide

Pfizer

Phase 2

940

Arizona, California, Florida, Georgia, Illinois, Kansas, Louisiana, Maryland

2026-05-11

Recruiting

Stunting and Targeting Reduction of Impaired Growth in Kids Effectively

NCT07524907Malnutrition (Calorie)

Abbott Nutrition

Observational

158

Missouri

2026-05-11

Recruiting

A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Administered as Intramuscular Injection to Healthy Children 15 Months to 6 Years of Age

NCT07406360Measles, Measles-Mumps-Rubella+Chickenpox Vaccine

GlaxoSmithKline

Phase 3

1,209

Alabama, California, Florida, Georgia, Illinois, Michigan, Ohio, South Carolina

2026-05-11

Recruiting

A Study to Select a Dose Regimen (Part A) and to Investigate Overall Survival (Part B) With Nanvuranlat Compared With Physician's Best Choice in Participants Aged 18 Years or Older With Biliary Tract Cancer

NCT07265674Advanced Biliary Tract Cancer, Biliary Tract Cancer (BTC)

J-Pharma Co., Ltd.

Phase 3

480

California, Florida, Illinois, Kentucky, Louisiana, Michigan, Minnesota, Nevada

2026-05-11

Recruiting

A Clinical Trial to Evaluate Efficacy, Safety, and Pharmacokinetics of Gamunex in Participants With Secondary Antibody Deficiency Associated With Chronic Lymphocytic Leukemia, Multiple Myeloma, or Non-Hodgkin Lymphoma

NCT07582432Chronic Lymphocytic Leukemia, Multiple Myeloma, or Non-Hodgkin Lymphoma

DrugGamunex-C

Grifols Biologicals, LLC

Phase 3

Florida, Indiana, Maine, Ohio, Washington

2026-05-11

Cite this view

Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site. Derived from ClinicalTrials.gov. Retrieved 8 November 2026. https://priyalifescience.com/clinical-trials-usa?page=3

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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every industry-sponsored study on the registry that lists at least one investigative site in the US and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 9,120 studies in total at the last sync on 07 Nov 2026, 03:16 UTC. Academic and other non-industry sponsors are out of scope by design. The full list can be downloaded as CSV or queried as JSON through the register API.

How many clinical trials are recruiting in the US?

4,955 of the 9,120 studies in this register are recruiting new participants as of the 07 Nov 2026, 03:16 UTC sync. A further 482 have not yet opened recruitment, 3,309 are active but closed to new participants, and 374 are enrolling by invitation only. Eligibility for any study is decided by its study team.

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Browse trials by condition

Advanced Solid Tumor (143) Obesity (136) Breast Cancer (132) Multiple Myeloma (110) Advanced Solid Tumors (94) Overweight (87) Colorectal Cancer (86) Solid Tumor (83) Ovarian Cancer (78) Heart Failure (72) Prostate Cancer (72) Non-Small Cell Lung Cancer (71) Healthy (68) Cancer (64) Melanoma (60)

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Browse trials by state

California (5303) Florida (4471) Illinois (2484) Georgia (2362) Arizona (2258) New York (2129) Colorado (2070) Texas (1973) Massachusetts (1840) Michigan (1473) Alabama (1313) Connecticut (1300) Maryland (1257) Ohio (1246) Indiana (1124)

Listing here is informational and not medical advice; eligibility is determined by each study team. Compare pay for the teams running these studies in the US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish, UK and EU sites, see the Ireland, UK and EU registers.