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Updated 11 Sep 2026 · ClinicalTrials.gov

Clinical Trials in the UK

The most recently updated industry-sponsored clinical trials recruiting across the United Kingdom — searchable by condition, sponsor, phase and city. Refreshed daily from the ClinicalTrials.gov registry.

112
Recruiting now
160
Studies tracked
141
Cities with sites
Active Phase 3
Determine Effectiveness of Anifrolumab In SYstemic Sclerosis (DAISY)
Systemic Sclerosis, Scleroderma
AstraZeneca · started 2023-11-08
Cannock · Leeds · London · Sheffield
NCT05925803 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer
Metastatic Breast Cancer
Hoffmann-La Roche · started 2018-03-30
Glasgow · London
NCT03424005 on ClinicalTrials.gov ↗
By invitation Phase 2/Phase 3
HELIOS: Open-Label, Long-Term Extension Study to Investigate the Safety, Tolerability, and Efficacy of DISC-1459 (Bitopertin) in Participants With EPP or XLP
Erythropoietic Protoporphyria
Disc Medicine, Inc · started 2023-08-31
London · Dundee · Salford
NCT05883748 on ClinicalTrials.gov ↗
Active
Versius Paediatrics Study
Robotic Surgical Procedures in Pediatric Urology
CMR Surgical Ltd · started 2024-07-08
London · Manchester · Southampton
NCT06539442 on ClinicalTrials.gov ↗
Recruiting Phase 2
Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Chronic Inflammatory Demyelinating Polyneuropathy
Immunovant Sciences GmbH · started 2025-03-18
Bristol · Glasgow · Salford · Southampton
NCT07032662 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Trontinemab in Cognitively Unimpaired Individuals at Risk for Progression to Symptomatic Alzheimer's Disease
Alzheimer's Disease
Hoffmann-La Roche · started 2026-11-30
Chertsey
NCT07717411 on ClinicalTrials.gov ↗
Recruiting Phase 1
First in Human Safety and Ease of Use Assessment of 400mg Progesterone Callavid in Women With Luteal Phase Insufficiency
Luteal Phase Insuffiency, Progesterone Delivery
Calla Lily Clinical Care Ltd · started 2026-04-20
Coventry
NCT07136922 on ClinicalTrials.gov ↗
Recruiting Phase 3
Efficacy and Safety of Intranasal Cenegermin in Adult Participants With Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)
Non-Arteritic Anterior Ischemic Optic Neuropathy
Dompé Farmaceutici S.p.A · started 2026-07-01
London · Liverpool
NCT07453888 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms
Neoplasms
Janssen Research & Development, LLC · started 2023-12-20
London · Oxford
NCT06150157 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
Advanced Non-small Cell Lung Cancer, HER2 Mutation
Bayer · started 2024-08-28
Torquay · Belfast · Guildford · Cardiff
NCT06452277 on ClinicalTrials.gov ↗
Recruiting Phase 2
Trial Comparing the Safety and Efficacy of Two Different Oral VPV Doses With Placebo as Treatment for RV in Participants With COPD
Rhinovirus Infection
Altesa Biosciences, Inc. · started 2026-05-01
Bromborough · Glasgow · London · Milton Keynes · Wolverhampton
NCT07610395 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE
Lupus Erythematosus, Systemic
AstraZeneca · started 2025-04-21
Bristol
NCT06897930 on ClinicalTrials.gov ↗
Recruiting Phase 1
Safety, Pharmacokinetics, and Preliminary Efficacy of VIR-5500 (AMX-500) in Prostate Cancer
Hormone-refractory Prostate Cancer
Astellas Pharma Global Development, Inc. · started 2023-08-10
London
NCT05997615 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
Study to Evaluate Switching to Brelovitug for the Treatment of CHD in Participants Receiving Bulevirtide
Chronic Hepatitis D
Mirum Pharmaceuticals, Inc. · started 2026-02-26
Cottingham · Cardiff · London · Manchester
NCT07454837 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors
MTAP-deleted Solid Tumors
Bayer · started 2025-03-21
Manchester · Sutton
NCT06914128 on ClinicalTrials.gov ↗
Active Phase 2
A Study of Mosliciguat in PH-ILD
Pulmonary Hypertension, Interstitial Lung Disease, Lung Diseases, Vascular Diseases
Pulmovant, Inc. · started 2024-10-29
Cambridge · London · Clydebank
NCT06635850 on ClinicalTrials.gov ↗
Active Phase 2
A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors
Ovarian Cancer
Hoffmann-La Roche · started 2021-10-07
Edinburgh · London
NCT04931342 on ClinicalTrials.gov ↗
Recruiting
Safety and Effectiveness of Orbera365™ Intragastric Balloon System
Obesity
Boston Scientific Corporation · started 2026-04-07
Coventry
NCT07062094 on ClinicalTrials.gov ↗
Active Phase 2
A Study to Test Whether BI 3034701 Helps People to Lose Weight Who Live With Obesity or Overweight
Obesity, Overweight
Boehringer Ingelheim · started 2026-06-30
Blackpool · Guisborough · High Wycombe · Leicester · Middlesbrough
NCT07662122 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Phase III Study to Assess the Effect of FDC Laroprovstat/Rosuvastatin Compared With Laroprovstat, Rosuvastatin and Placebo on LDL-C in LLT-naïve Patients.
Hypercholesterolaemia
AstraZeneca · started 2026-08-12
Coventry · Knutsford · London · Orpington · Poole
NCT07619131 on ClinicalTrials.gov ↗
Recruiting Phase 3
An Efficacy and Safety Study of Intravenous Anifrolumab to Treat Systemic Lupus Erythematosus in Pediatric Participants
Systemic Lupus Erythematosus
AstraZeneca · started 2024-03-14
Birmingham · Bristol · Liverpool · London · Manchester
NCT05835310 on ClinicalTrials.gov ↗
Active Phase 2
A Study Evaluating APG777 in Atopic Dermatitis
Atopic Dermatitis
Apogee Therapeutics, Inc. · started 2024-04-29
Salford · Dudley · London
NCT06395948 on ClinicalTrials.gov ↗
Active Phase 2
Study of Efficacy and Safety of JDQ443 Single-agent as First-line Treatment for Patients With Locally Advanced or Metastatic KRAS G12C- Mutated Non-small Cell Lung Cancer With a PD-L1 Expression < 1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation.
Locally Advanced or Metastatic KRAS G12C-mutated NSCLC With a PD-L1 Expression <1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation
Novartis Pharmaceuticals · started 2022-12-06
Torquay
NCT05445843 on ClinicalTrials.gov ↗
Recruiting Phase 2
Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD
Geographic Atrophy (GA), Age - Related Macular Degeneration (AMD)
ONL Therapeutics · started 2025-10-28
Gloucester · London · Newcastle · Southampton · Sunderland
NCT06659445 on ClinicalTrials.gov ↗
Recruiting Phase 3
Pridopidine Phase 3 Study in Huntington's Disease
Huntington Disease
Prilenia · started 2026-07-01
Aberdeen · Birmingham · Cardiff · Liverpool · Newcastle upon Tyne
NCT07609108 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
Pancreatic Neuroendocrine Tumor (pNET), Extra-Pancreatic Neuroendocrine Tumor (epNET)
Exelixis · started 2025-07-21
Birmingham · Cardiff · Glasgow · Liverpool · London
NCT06943755 on ClinicalTrials.gov ↗
Active Phase 3
A Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated · started 2022-11-08
Birmingham · Bristol · Cambridge · Edinburgh · Exeter
NCT05444257 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
CR-001 in Adult Participants With Locally Advanced or Metastatic Solid Tumors
Locally Advanced / Metastatic Solid Tumors
Crescent Biopharma, Inc. · started 2026-02-17
Manchester
NCT07335497 on ClinicalTrials.gov ↗
Active Phase 2
Efficacy and Safety of IMVT-1402 in Adult Participants With Primary Sjogren's Disease With Moderate to Severe Systemic Disease Activity
Primary Sjögren's Syndrome
Immunovant Sciences GmbH · started 2025-06-30
Cambridge · Liverpool · London · Swindon · Truro
NCT06979531 on ClinicalTrials.gov ↗
Recruiting Phase 3
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
Solid Tumors, Hematologic Malignancies
Merck Sharp & Dohme LLC · started 2018-08-21
Aberdeen · Cambridge · Edinburgh · Manchester · Sheffield
NCT03486873 on ClinicalTrials.gov ↗
Active Phase 3
Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency
Hormone-Sensitive Prostate Cancer
AstraZeneca · started 2020-07-13
Cambridge · Guildford · Manchester · Plymouth · Sutton
NCT04493853 on ClinicalTrials.gov ↗
Recruiting Phase 1
Phase 1 Study of ADX-626 in Healthy Participants
Healthy Adult Participants
ADARx Pharmaceuticals, Inc. · started 2025-08-12
London
NCT07081503 on ClinicalTrials.gov ↗
Active Phase 1/Phase 2
A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes
Type 1 Diabetes
Vertex Pharmaceuticals Incorporated · started 2023-05-16
Headington · Newcastle upon Tyne
NCT05791201 on ClinicalTrials.gov ↗
Active Phase 1
Dose Optimization and Expansion Study of DFV890 in Adult Patients With Myeloid Diseases
Myeloid Diseases
Novartis Pharmaceuticals · started 2023-05-08
Cardiff · London · Manchester
NCT05552469 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS
Amyotrophic Lateral Sclerosis
Vector Y Therapeutics · started 2025-12-19
London · Sheffield
NCT07287397 on ClinicalTrials.gov ↗
Recruiting Phase 2
Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)
Acute Respiratory Distress Syndrome, Infections
BioAegis Therapeutics Inc. · started 2024-10-03
Cardiff · Plymouth · Wakefield
NCT05947955 on ClinicalTrials.gov ↗
Recruiting Phase 2
Prevention of Recurrent C. Difficile Infection Study With AZD5148 Monoclonal Antibody
Clostridioides Difficile Infection
AstraZeneca · started 2025-12-10
Birmingham · Cambridge · Cardiff · Newcastle
NCT07285213 on ClinicalTrials.gov ↗
Recruiting Phase 1
Single and Multiple Dose Pharmacokinetics (PK) of Aramchol From an Aramchol Meglumine Tablet
Healthy
Galmed Pharmaceuticals Ltd · started 2025-12-25
London
NCT07251712 on ClinicalTrials.gov ↗
Recruiting Phase 4
A Study Evaluating the Effectiveness and Safety of Risdiplam Administered in Pediatric Patients With Spinal Muscular Atrophy Who Experienced a Plateau or Decline in Function After Gene Therapy
Muscular Atrophy, Spinal
Hoffmann-La Roche · started 2024-08-14
London
NCT05861999 on ClinicalTrials.gov ↗
Active Phase 3
Placebo-controlled, Study of Concurrent Chemoradiation Therapy With Pembrolizumab Followed by Pembrolizumab and Olaparib in Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK 7339-013/KEYLYNK-013)
Small Cell Lung Cancer
Merck Sharp & Dohme LLC · started 2020-12-08
Aberdeen · Dundee · Taunton · London · Manchester
NCT04624204 on ClinicalTrials.gov ↗
Recruiting Phase 3
STOP-HAE: A Phase 3 Study of ADX-324 in HAE
Hereditary Angioedema, HAE, Hereditary Angioedema - Type 1, Hereditary Angioedema - Type 2
ADARx Pharmaceuticals, Inc. · started 2025-08-28
Guildford · Cambridge · Cardiff · London · Southampton
NCT06960213 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Evaluate Effect of AZD6234 as an Adjunct to Incretin-based Therapies in Adult Participants With Obesity or Overweight With Weight-related Comorbidity With or Without Type 2 Diabetes Mellitus
Obesity or Overweight, Weight-Related Comorbidity, With/Without Diabetes Mellitus, Type 2
AstraZeneca · started 2026-08-24
Airdrie · Chippenham · Hull · Llandough · Rotherham
NCT07776509 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
FiH Study to Investigate Safety, PK and Efficacy of the NaPi2b ADC TUB-040 in Patients With PROC or r/r Adenocarcinoma NSCLC
Ovarian Cancer, Non-small Cell Lung Cancer
Tubulis GmbH · started 2024-06-12
London
NCT06303505 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Investigate the Efficacy and Safety of SC0032, a Magnesium Salt Oral Spray, in Adults With Refractory or Unexplained Chronic Cough
Refractory Chronic Cough and Unexplained Chronic Cough
Sensory Cloud, Inc. · started 2026-07-13
Belfast · London
NCT07690059 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM
Weight Management
AstraZeneca · started 2026-06-29
Ashton-under-Lyne · Blackpool · Chesterfield · Corby · Ely
NCT07667803 on ClinicalTrials.gov ↗
Active Phase 2
A Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7204239 in Combination With Tirzepatide in Participants With Obesity or Overweight With At Least One Weight-related Comorbidity
Obesity, Overweight, Overweight With One Weight Related Comorbidity
Hoffmann-La Roche · started 2025-05-05
Blackpool · Leicester · Shipley · Coventry · Northwood
NCT06965413 on ClinicalTrials.gov ↗
Active Phase 2/Phase 3
A Study to Determine the Efficacy and Safety of Tividenofusp Alfa (DNL310) vs Idursulfase in Pediatric and Young Adult Participants With Neuronopathic (nMPS II) or Non-Neuronopathic Mucopolysaccharidosis Type II (nnMPS II)
Mucopolysaccharidosis II
Denali Therapeutics Inc. · started 2022-07-21
London · Birmingham · Salford
NCT05371613 on ClinicalTrials.gov ↗
Active Phase 3
Assessment of Efficacy and Safety of Monalizumab Plus Cetuximab Compared to Placebo Plus Cetuximab in Recurrent or Metastatic Head and Neck Cancer
Squamous Cell Carcinoma of the Head and Neck
AstraZeneca · started 2020-10-02
London · Manchester · Newcastle upon Tyne · Sutton
NCT04590963 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Eptinezumab in Pediatric Participants With Episodic Migraine
Episodic Migraine
H. Lundbeck A/S · started 2023-06-08
Edinburgh · Great Yarmouth · Glasgow · London
NCT05897320 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Gammagard Liquid (Immune Globulin Infusion, 10%) to Prevent Infections in Adults With Multiple Myeloma
Multiple Myeloma, Secondary Immunodeficiency
Takeda · started 2026-01-14
Exeter · Colcester · Gloucester · Cardiff · Milton Keynes
NCT06980480 on ClinicalTrials.gov ↗
Active
Polycystic Kidney Disease 1 (PKD1) Gene Variant Groups in Autosomal Dominant Polycystic Kidney Disease
Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Vertex Pharmaceuticals Incorporated · started 2024-12-19
Birmingham · London · Newcastle upon Tyne · Sheffield
NCT06747572 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
FUNCtion ALS: Aiming to Restore UNC13A Function in People Living With ALS
Amyotrophic Lateral Sclerosis
Trace Neuroscience, Inc. · started 2026-08-20
Sheffield
NCT07674667 on ClinicalTrials.gov ↗
Recruiting
OverTTuRe: Characteristics, Treatment Patterns and Outcomes of Patients With ATTR Amyloidosis
ATTR Amyloidosis
AstraZeneca · started 2023-08-21
London
NCT06355934 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Investigate Efficacy and Safety of Teplizumab Compared With Placebo in Participants 1 to 25 Years of Age With Stage 3 Type 1 Diabetes
Type 1 Diabetes Mellitus
Sanofi · started 2025-08-06
Cambridge · Dundee · London · Glasgow · Bath
NCT07088068 on ClinicalTrials.gov ↗
By invitation Phase 3
Long-Term Extension Study of Vosoritide to Treat Children With Hypochondroplasia
Hypochondroplasia
BioMarin Pharmaceutical · started 2025-06-20
London
NCT07073014 on ClinicalTrials.gov ↗
Active Phase 3
A Study of Osimertinib With or Without Chemotherapy Versus Chemotherapy Alone as Neoadjuvant Therapy for Patients With EGFRm Positive Resectable Non-Small Cell Lung Cancer
Non-Small Cell Lung Cancer
AstraZeneca · started 2020-12-16
Birmingham · Liverpool
NCT04351555 on ClinicalTrials.gov ↗
Active
Development of a New Patient Reported Outcome Measure (PROM) to Assess Patient's Emotional Wellbeing, and Perceptions of Total Knee Replacement Surgery for the Treatment of Knee Arthritis
Complete Questionnaires Following TKR Surgery
Invibio Ltd · started 2024-10-07
Leeds
NCT06585267 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Study to Evaluate the Safety and Efficacy of Gocatamig (MK-6070) and Ifinatamab Deruxtecan (I-DXd) in Participants With Relapsed/Refractory Extensive-Stage Small Cell Lung Cancer (MK-6070-002)
Small Cell Lung Cancer
Merck Sharp & Dohme LLC · started 2025-02-27
London · Liverpool · Manchester
NCT06780137 on ClinicalTrials.gov ↗
Active Phase 1/Phase 2
First-in-Human (FIH) Trial in Patients With Relapsed, Progressive or Refractory B-Cell Lymphoma
DLBCL, High-grade B-cell Lymphoma (HGBCL), Primary Mediastinal Large B-cell Lymphoma (PMBCL), FL
Genmab · started 2018-06-26
Manchester · Plymouth · Southampton · Sutton
NCT03625037 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Learn About a Clostridioides Difficile Vaccine in People 65 Years of Age and Older
Clostridoides Difficile Associated Disease
Pfizer · started 2025-12-10
Newquay · Exeter · Plymouth · Torquay · Preston
NCT07282665 on ClinicalTrials.gov ↗
Active Phase 2
A Gene Delivery Study to Evaluate the Safety and Expression of Delandistrogene Moxeparvovec in Participants Under the Age of Four With Duchenne Muscular Dystrophy (DMD)
Duchenne Muscular Dystrophy
Hoffmann-La Roche · started 2023-11-29
London · Oxford
NCT06128564 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Vonicog Alfa (rVWF) in Children With Severe Von Willebrand Disease (vWD)
Von Willebrand Disease (VWD)
Takeda · started 2024-11-06
London · Oxford
NCT05582993 on ClinicalTrials.gov ↗
Recruiting Phase 4
A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK)
Obesity
Eli Lilly and Company · started 2025-11-24
Altrincham · Ashton-under-Lyne · Bolton · Bury · Cheshire
NCT07247084 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
RIG 101 Trial in Healthy Adults and Adults With Asthma
Healthy Adult Participants, Asthma Exacerbation, Safety and Efficacy
RIGImmune Inc. · started 2026-02-09
London · Manchester
NCT07488897 on ClinicalTrials.gov ↗
Recruiting Phase 3
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
Triple Negative Breast Cancer
Gilead Sciences · started 2022-12-12
Cottingham · Edgbaston · Liverpool · London · Manchester
NCT05633654 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have or Have Not Been Treated With Biologic Medicines
Psoriatic Arthritis
Takeda · started 2025-03-10
London · Coventry · Bradford · Harlow · Oxford
NCT06671496 on ClinicalTrials.gov ↗
Recruiting
PRostate Cancer Enhanced Diagnosis by Calibration Technology
Prostate Cancers
Gold Standard Phantoms · started 2026-06-26
London
NCT06607783 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Investigate Efficacy and Safety of FWY003 Compared With Placebo in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration
Geographic Atrophy Secondary to Age-related Macular Degeneration
Novartis Pharmaceuticals · started 2026-03-09
Bristol · London · Newcastle upon Tyne · Southampton
NCT07441642 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Phase 1/1b Study of IAM1363 in HER2 Cancers
HER2 Mutation-Related Tumors, HER2, HER2-positive Breast Cancer, HER2 + Breast Cancer
Iambic Therapeutics, Inc · started 2024-03-25
Chelsea · Oxford · Sutton
NCT06253871 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
Relapsed or Refractory Multiple Myeloma
Celgene · started 2022-09-20
Cambridge · Truro · Airdrie · London · Leicester
NCT05519085 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Clinical Study to Evaluate Ianalumab in Participants With Diffuse Cutaneous Systemic Sclerosis
Diffuse Cutaneous Systemic Sclerosis
Novartis Pharmaceuticals · started 2024-10-09
Basingstoke · Bristol · London
NCT06470048 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
Type 2 Diabetes Mellitus
AstraZeneca · started 2026-07-06
Aberdeen · Addlestone · Banbury · Bristol · Edinburgh
NCT07662213 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Investigate Outcomes With Elecoglipron Compared With Placebo in Adult Participants With Chronic Kidney Disease.
Chronic Kidney Disease
AstraZeneca · started 2026-08-21
Aberdeen · Cardiff · Corby · Coventry · Dundee
NCT07753993 on ClinicalTrials.gov ↗
Active Phase 3
ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack
Cardiovascular Risk, Acute Myocardial Infarction (AMI)
Novo Nordisk A/S · started 2024-06-25
Truro · Torquay · Bournemouth · Ashford · Blackpool
NCT06118281 on ClinicalTrials.gov ↗
Recruiting Phase 4
Real-World Effectiveness and Safety of Pegcetacoplan in Patients With C3G or IC-MPG: A Multi-Country Study
C3 Glomerulopathy (C3G), Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN)
Swedish Orphan Biovitrum · started 2026-08-05
Cambridge · Cardiff · Glasgow · Leicester · London
NCT07746895 on ClinicalTrials.gov ↗
Active Phase 2
A Study of the Efficacy and Safety of Adjuvant Autogene Cevumeran Plus Atezolizumab and mFOLFIRINOX Versus mFOLFIRINOX Alone in Participants With Resected PDAC
Adenocarcinoma, Pancreatic Ductal
Genentech, Inc. · started 2023-10-18
Liverpool · Belfast · Birmingham · Cambridge · London
NCT05968326 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)
Radiographic Axial Spondyloarthritis
Merck Sharp & Dohme LLC · started 2025-09-26
Norwich · Bath · Barnet · Bradford
NCT07133633 on ClinicalTrials.gov ↗
Active Phase 3
A Phase III, Open-Label Study of Maintenance Lurbinectedin in Combination With Atezolizumab Compared With Atezolizumab in Participants With Extensive-Stage Small-Cell Lung Cancer
Small-Cell Lung Cancer
Hoffmann-La Roche · started 2021-11-18
Blackpool · GB Manchester · Hull · Leeds · Leicester
NCT05091567 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Clinical Study to Evaluate the Effects of NXT007 Compared to Factor VIII Prophylaxis in Participants With Hemophilia A
Hemophilia A
Hoffmann-La Roche · started 2026-05-15
London · Cardiff
NCT07416526 on ClinicalTrials.gov ↗
Recruiting Phase 3
Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2
Gastric Cancer, Gastroesophageal Junction Adenocarcinoma, Esophageal Cancer
AstraZeneca · started 2026-02-03
Cambridge · Dundee · Leeds · London · Manchester
NCT07431281 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Evaluate Efficacy and Safety of MK-8690 in Participants With Moderately to Severely Active Ulcerative Colitis (MK-8690-002)
Colitis Ulcerative, Ulcerative Colitis
Merck Sharp & Dohme LLC · started 2026-03-24
Bury · Huddersfield
NCT07463183 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Investigate the Long-term Safety and Efficacy of Belimumab in Adults With Interstitial Lung Disease (ILD) Associated With Systemic Sclerosis (SSc) and Other Connective Tissue Diseases (CTD) (BLISSconneCTD-OLE)
Connective Tissue Diseases
GlaxoSmithKline · started 2024-12-12
Leeds · London
NCT06716606 on ClinicalTrials.gov ↗
Active Phase 3
Research Study to Look at How Well the Drug Concizumab Works in Your Body if You Have Haemophilia With Inhibitors
Haemophilia A With Inhibitors, Haemophilia B With Inhibitors
Novo Nordisk A/S · started 2019-10-21
Birmingham · London · Manchester · Nottingham · Sheffield
NCT04083781 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD)
AstraZeneca · started 2025-06-27
Bradford · Cottingham · Glasgow · Harrow · London
NCT07082738 on ClinicalTrials.gov ↗
Active Phase 1
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7812653 in Participants With Early Symptomatic Alzheimer's Disease (eAD)
Alzheimer's Disease
Hoffmann-La Roche · started 2026-01-27
London · Southampton · Glasgow
NCT07234942 on ClinicalTrials.gov ↗
Starting soon
Weight and Metabolic Management Study
Overweight, Obesity, Weight Maintenance
Elenzia · started 2026-09
Redditch
NCT07789223 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
Colon Adenocarcinoma, Rectal Adenocarcinoma
Merck Sharp & Dohme LLC · started 2025-07-16
Birmingham · London · Oxford · Coventry · Cardiff
NCT06997497 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)
Non-small Cell Lung Cancer
Merck Sharp & Dohme LLC · started 2025-10-08
Truro · London · Birmingham · Leicester
NCT07190248 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine
Episodic Migraine
AbbVie · started 2023-05-01
London · Gillingham · Aberdeen · Stockport
NCT05711394 on ClinicalTrials.gov ↗
Recruiting Phase 3
Extension Study of Long-term Safety and Efficacy of Tulisokibart in Participants With Crohn's Disease or Ulcerative Colitis (MK-7240-011)
Crohn Disease, Colitis, Ulcerative
Merck Sharp & Dohme LLC · started 2024-11-25
London · Prescot
NCT06651281 on ClinicalTrials.gov ↗
Recruiting
Observational Study of Acalabrutinib in Patients With Chronic Lymphocytic Leukaemia in the United Kingdom
Chronic Lymphocytic Leukemia, CLL
AstraZeneca · started 2022-10-17
Aylesbury · Bath · Birmingham · Bournemouth · Cardiff
NCT05557695 on ClinicalTrials.gov ↗
Active Phase 3
A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes
Diabetes Mellitus, Type 2
Novo Nordisk A/S · started 2019-05-08
Harrogate · Nottingham · Yeovil · London · Norfolk
NCT03811561 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
PS-002 for the Treatment of IgA Nephropathy in Adults
Immunoglobulin A (IgA) Nephropathy
Purespring Therapeutics Limited · started 2026-03-30
Manchester · Leicester · Nottingham · Bristol · Cardiff
NCT07182227 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
Heart Failure With Preserved Ejection Fraction (HFpEF), Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)
AstraZeneca · started 2026-08-24
Ashton-under-Lyne · Basildon · Belfast · Birmingham · Brighton
NCT07761117 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Follow-up Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia
Immune Thrombocytopenic Purpura (ITP)
Takeda · started 2025-08-14
Leicester · Southampton · Southwark · Liverpool · Glasgow
NCT06948318 on ClinicalTrials.gov ↗
Active Phase 3
A Research Study on How Well Semaglutide Helps Children and Teenagers With Excess Body Weight Lose Weight
Obesity
Novo Nordisk A/S · started 2023-07-07
Birmingham · Bristol · Leeds · Liverpool · Southampton
NCT05726227 on ClinicalTrials.gov ↗
Active Phase 3
Long-term Extension of GTX-102 in Angelman Syndrome
Angelman Syndrome
Ultragenyx Pharmaceutical Inc · started 2024-07-31
Cambridge · London · Oxford
NCT06415344 on ClinicalTrials.gov ↗
Recruiting
DEFIANCE: RCT of ClotTriever System Versus Anticoagulation In Deep Vein Thrombosis
Venous Thromboembolism, Deep Venous Thrombosis, Post-Thrombotic Syndrome
Inari Medical · started 2023-01-06
London · Newcastle upon Tyne · Oxford
NCT05701917 on ClinicalTrials.gov ↗
Active Phase 2/Phase 3
A Study to Investigate the Safety and Efficacy of RO7204239 in Combination With Risdiplam (RO7034067) in Participants With Spinal Muscular Atrophy
Spinal Muscular Atrophy (SMA)
Hoffmann-La Roche · started 2022-06-02
Birmingham · Oxford
NCT05115110 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
Non Small Cell Lung Cancer
AbbVie · started 2022-03-25
London · Nottingham · Birmingham · Manchester
NCT04928846 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study to Assess Adverse Events and How Intravenous (IV) Pivekimab Sunirine Moves Through the Body in Pediatric Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML)
Acute Myeloid Leukemia
AbbVie · started 2026-05-20
Cambridge
NCT07306832 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias
Cardiovascular, Metabolic Disease, Dyslipidemias, Lipid Disorder
CRISPR Therapeutics AG · started 2024-06-21
Cambridge · London
NCT07491172 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.
Healthy Participants, Obesity
AstraZeneca · started 2026-03-30
Harrow
NCT07511205 on ClinicalTrials.gov ↗
Starting soon Phase 2
A Study to Evaluate the Efficacy of VVD-133214 in Combination With Pembrolizumab Compared With Pembrolizumab Alone in Participants With Advanced Cancer of the Colon or Rectum
Colorectal Adenocarcinoma
Vividion Therapeutics, Inc. · started 2026-09-15
London · Coventry
NCT07811193 on ClinicalTrials.gov ↗
Active Phase 1/Phase 2
Safety and Efficacy Trial of Epcoritamab Combinations in Subjects With B-cell Non-Hodgkin Lymphoma (B-NHL)
Diffuse Large B-Cell Lymphoma, Follicular Lymphoma
Genmab · started 2020-11-03
Manchester · Newcastle upon Tyne · Plymouth
NCT04663347 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer
Breast Neoplasms, Brain Neoplasms, Neoplasms by Site, Neoplasms
Stemline Therapeutics, Inc. · started 2022-08-31
Leicester · Liverpool · London · Manchester
NCT05386108 on ClinicalTrials.gov ↗
Recruiting Phase 3
Single-arm Study of IgPro20 in Adults With Secondary Immune Deficiencies Due to Hematologic Malignancies Treated With B-cell Targeting Chimeric Antigen Receptor T-cell and T-cell Redirecting Therapies
Secondary Immune Deficiency
CSL Behring · started 2026-09-11
London · Leicester
NCT07648264 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)
Metastatic Colorectal Cancer
EMD Serono Research & Development Institute, Inc. · started 2026-05-06
Aberdeen · Manchester
NCT07549412 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
Pulmonary Arterial Hypertension
Merck Sharp & Dohme LLC · started 2021-05-12
Cambridge · Glasgow · London · Newcastle upon Tyne · Sheffield
NCT07218029 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)
Coronavirus Disease (COVID-19)
Merck Sharp & Dohme LLC · started 2024-12-02
Bristol · Exeter · Newcastle · Norwich · Northamptonshire
NCT06667700 on ClinicalTrials.gov ↗
Active Phase 2
A Safety and Efficacy Study of GTX-102 in Subjects With Deletion- or Nondeletion-type Angelman Syndrome (AS)
Angelman Syndrome
Ultragenyx Pharmaceutical Inc · started 2025-10-13
London · Oxford
NCT07157254 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney Disease
Proteinuric Kidney Disease
Vertex Pharmaceuticals Incorporated · started 2022-03-30
Basildon · Bellshill · Birmingham · Carshalton · Leicester
NCT05312879 on ClinicalTrials.gov ↗
Active Phase 3
Extension Study to Evaluate Safety and Tolerability of Oral Dersimelagon (MT-7117) in Subjects With Erythropoietic Protoporphyria (EPP) or X-Linked Protoporphyria (XLP)
EPP, XLP
Tanabe Pharma America, Inc. · started 2021-08-10
Manchester · London
NCT05005975 on ClinicalTrials.gov ↗
Active Phase 3
Trial to Evaluate Acasunlimab and Pembrolizumab Combination Superiority Over Standard of Care Docetaxel in Non-Small Cell Lung Cancer (ABBIL1TY NSCLC-06)
PD-L1-positive, Locally Advanced (Unresectable Stage IIIB/C) or Metastatic NSCLC
Genmab · started 2024-11-25
Glasgow · London · Manchester · Nottingham · Plymouth
NCT06635824 on ClinicalTrials.gov ↗
Active Phase 3
Study to Evaluate the Efficacy and Safety of BBP-418 (Ribitol) in Patients With Limb Girdle Muscular Dystrophy 2I (LGMD2I)
Limb-Girdle Muscular Dystrophy Type 2I (LGMD2I)
ML Bio Solutions, Inc. · started 2023-05-31
London · Newcastle upon Tyne
NCT05775848 on ClinicalTrials.gov ↗
Active Phase 3
A Research Study Looking at Long-term Treatment With Mim8 in People With Haemophilia A
Haemophilia A, Haemophilia A With Inhibitors
Novo Nordisk A/S · started 2023-02-13
Belfast · Cardiff · London · Sheffield
NCT05685238 on ClinicalTrials.gov ↗
Active Phase 1
A Study in People With Overweight or Obesity to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body
Healthy, Obesity, Overweight
Boehringer Ingelheim · started 2026-03-11
Nottingham
NCT07407348 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Assess the Efficacy and Safety of Emicizumab in Participants With Type 3 Von Willebrand Disease
Von Willebrand Disease, Type 3
Hoffmann-La Roche · started 2025-06-27
London · Manchester
NCT06998524 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
Crohn's Disease
Merck Sharp & Dohme LLC · started 2024-06-05
Cambridge · Exeter · Doncaster · Huddersfield · London
NCT06430801 on ClinicalTrials.gov ↗
Recruiting Phase 3
ATSN-201 Gene Therapy in RS1-Associated X-linked Retinoschisis
X-linked Retinoschisis
Atsena Therapeutics Inc. · started 2023-08-22
Oxford
NCT05878860 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-2)
Severe Asthma
Generate Biomedicines · started 2026-01-20
High Wycombe · Bristol · London · Romford · Rotherham
NCT07359846 on ClinicalTrials.gov ↗
Recruiting Phase 1
Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas
Ewing Sarcoma, Colorectal Adenocarcinoma
Inhibrx Biosciences, Inc · started 2018-10-08
London · Manchester
NCT03715933 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies
Chronic Lymphocytic Leukaemia, Small Lymphocytic Lymphoma, Mantle-cell Lymphoma, Large B-cell Lymphoma
AstraZeneca · started 2025-01-30
Derriford · London · Oxford · Southampton
NCT06564038 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis
Eli Lilly and Company · started 2023-12-21
Aberdeen · Dundee · Huddersfield · Leeds · Manchester
NCT06119581 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Diarrhea (IBS-D)
Irritable Bowel Syndrome, Diarrhea
Eli Lilly and Company · started 2026-05-06
Cheadle · Hounslow · Macclesfield · Newcastle upon Tyne · Newquay
NCT07545759 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH
NASH - Nonalcoholic Steatohepatitis, MASH - Metabolic Dysfunction-Associated Steatohepatitis
Akero Therapeutics, Inc · started 2024-09-04
London · Nottingham · Birmingham · Newcastle upon Tyne · Whitechapel
NCT06528314 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of LY4005130 in Adult Participants With Severe Alopecia Areata (Hair Loss)
Alopecia Areata
Eli Lilly and Company · started 2026-04-14
London · Salford
NCT07533006 on ClinicalTrials.gov ↗
Active Phase 1/Phase 2
A Phase 1/2 Study of VX-522 in Participants With Cystic Fibrosis (CF)
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated · started 2023-02-27
Cambridge · Glasgow · London · Manchester · Penarth
NCT05668741 on ClinicalTrials.gov ↗
Active Phase 2/Phase 3
A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1
Unresectable Head and Neck Squamous Cell Carcinoma, Metastatic Head and Neck Cancer, Recurrent Head and Neck Cancer
BioNTech SE · started 2021-01-07
Aberdeen · Belfast · Birmingham · Cambridge · Cardiff
NCT04534205 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)
Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma
Bristol-Myers Squibb · started 2026-03-13
London · Oxford · Sutton · Glasgow · Manchester
NCT07221149 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung Disease
Systemic Sclerosis Associated Interstitial Lung Disease, Scleroderma, Systemic
GlaxoSmithKline · started 2023-09-13
Wakefield · Birmingham · Leeds · London · Portsmouth
NCT05878717 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation
Non-Small Cell Lung Cancer
Hoffmann-La Roche · started 2023-06-20
Glasgow · London
NCT05789082 on ClinicalTrials.gov ↗
Recruiting Phase 1
Anti-GD2 ADC M3554 in Advanced Solid Tumors
Advanced Solid Tumor
EMD Serono Research & Development Institute, Inc. · started 2024-11-08
Sutton
NCT06641908 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk
Atherosclerosis, Cardiovascular Diseases, Lipoprotein(a)
Eli Lilly and Company · started 2026-06-01
Birmingham · Bristol · Cheadle · Lancaster · Lincoln
NCT07613294 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
Non-Small Cell Lung Cancer, KRAS G12C Lung Cancer
Hoffmann-La Roche · started 2025-10-24
Blackpool · Bristol · Canterbury · Cardiff · Hull
NCT06793215 on ClinicalTrials.gov ↗
Recruiting Phase 3
Pivotal Study of N-acetyl-L-leucine for CACNA1A
CACNA1A, Spinocerebellar Ataxia Type 6, Episodic Ataxia Type 2, Familial Hemiplegic Migraine-1
IntraBio Inc · started 2026-08-17
Newcastle upon Tyne · Oxford
NCT07221292 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer
Breast Cancer
Hoffmann-La Roche · started 2026-04-07
Leicester · London · Manchester
NCT07405801 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Constipation (IBS-C)
Irritable Bowel Syndrome, Constipation
Eli Lilly and Company · started 2026-04-29
Cheadle · Hounslow · Macclesfield · Newcastle upon Tyne · Newquay
NCT07545772 on ClinicalTrials.gov ↗
Active Phase 2
A Study to Evaluate IPN10200 Safety and Efficacy in the Prevention of Episodic or Chronic Migraine in Adults
Episodic Migraine, Chronic Migraine
Ipsen · started 2024-10-10
Exeter · Hull · Liverpool · London
NCT06625060 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Test Whether Nerandomilast Can Help Slow Down Changes in the Lung in People With a Family History of Pulmonary Fibrosis
Familial Pulmonary Fibrosis, Interstitial Lung Abnormalities, Interstitial Lung Diseases
Boehringer Ingelheim · started 2026-02-10
Exeter · London
NCT07201922 on ClinicalTrials.gov ↗
Recruiting Phase 3
ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer
Breast Neoplasms
BioNTech SE · started 2025-10-30
Brighton · Bristol · Cottingham · Edinburgh · Leeds
NCT07173751 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
Advanced Solid Tumor, Melanoma, Head and Neck Cancer, Gastric Cancer
Daiichi Sankyo · started 2024-02-26
Coventry · London · Nottingham
NCT06172478 on ClinicalTrials.gov ↗
Active Phase 3
A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)
Obesity, Overweight and/or Obesity, Overweight, Diabetes, Type 2
Pfizer · started 2026-02-24
Hendon · Glasgow · Bellshill · Birmingham · Bristol
NCT07400653 on ClinicalTrials.gov ↗
Recruiting Phase 3
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
Osteoarthritis, Overweight or Obesity
Eli Lilly and Company · started 2026-02-09
Bristol · Glasgow · London · Newcastle · Penzance
NCT07353931 on ClinicalTrials.gov ↗
Active
Characterization And Clinical Outcomes of AA Patients Treated With Ritlecitinib
Alopecia Areata
Pfizer · started 2024-08-07
Brighton · Dunfermline · Gloucester · Bath · Glasgow
NCT06531109 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer
Ovarian Neoplasms, Fallopian Tube Neoplasms, Peritoneal Neoplasms, Neoplasm Metastasis
Eli Lilly and Company · started 2025-10-22
Bath · Leeds · London · Manchester · Torquay
NCT07213804 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of IPN10200 for the Treatment of Cervical Dystonia in Adults
Cervical Dystonia
Ipsen · started 2025-06-30
Exeter · Fazakerley · London · Luton
NCT06937931 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy
Gastrointestinal Neoplasms
GlaxoSmithKline · started 2025-12-03
Manchester · Edinburgh · Cambridge · Leeds · London
NCT07218926 on ClinicalTrials.gov ↗
Recruiting Phase 3
Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
Metastatic Colorectal Cancer (CRC)
Summit Therapeutics · started 2025-11-18
Canterbury · London · Aberdeen · Edinburgh · Liverpool
NCT07228832 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab and a Combined Regimen of Mosunetuzumab and Venetoclax in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Hoffmann-La Roche · started 2022-03-07
Manchester · Oxford
NCT05091424 on ClinicalTrials.gov ↗
Starting soon Phase 2
Neoadjuvant Pembrolizumab and Porustobart in Resectable pMMR/MSS Colon Cancer
Colon Cancer, Microsatellite Stable (MSS) Colon Cancer, Proficient Mismatch Repair (pMMR) Colon Cancer
Solstice Oncology, Inc. · started 2026-09-30
Aberdeen · Cardiff · Glasgow · Leeds · London
NCT07808151 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Test Whether Nerandomilast Helps People With Lungfibrosis Related to Rheumatic Diseases
Interstitial Lung Diseases, Systemic Autoimmune Rheumatic Diseases Associated Interstitial Lung Diseases
Boehringer Ingelheim · started 2025-09-13
Antrim · Bath · Birmingham · Leeds · London
NCT06806592 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Afimkibart (RO7790121) in Children With Moderately to Severely Active Ulcerative Colitis
Moderately to Severely Active Ulcerative Colitis
Hoffmann-La Roche · started 2026-04-15
Birmingham · Cambridge · Sheffield
NCT07158242 on ClinicalTrials.gov ↗
Recruiting Phase 3
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
Carcinoma, Non-Small-Cell Lung
Eli Lilly and Company · started 2025-03-27
Birmingham · East Sussex · Huddersfield · London · Manchester
NCT06890598 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Test Whether Different Doses of BI 3000202 Help People With Systemic Lupus Erythematosus (SLE)
Systemic Lupus Erythematosus
Boehringer Ingelheim · started 2026-04-20
Basingstoke · Belfast · Cambridge · Doncaster · London
NCT07409181 on ClinicalTrials.gov ↗
Active Phase 1
To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer
Breast Cancer, Solid Tumor
Genentech, Inc. · started 2016-12-13
Surrey · London
NCT03006172 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of the Efficacy and Safety of Belimumab in Adults With Interstitial Lung Disease Associated With Connective Tissue Disease
Lung Diseases, Interstitial
GlaxoSmithKline · started 2024-09-11
Leicester · Birmingham · London
NCT06572384 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Long-term Safety and Efficacy Study Evaluating APG777 in Atopic Dermatitis
Atopic Dermatitis
Apogee Therapeutics, Inc. · started 2025-05-14
Salford
NCT07003425 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
Breast Neoplasms, Neoplasm Metastasis
Eli Lilly and Company · started 2025-12-22
Edinburgh · Huddersfield · London · Manchester · Plymouth
NCT07174336 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)
Non-small Cell Lung Cancer (NSCLC)
Bristol-Myers Squibb · started 2026-03-16
Manchester · Newcastle upon Tyne · Birmingham · Cambridge · Cardiff
NCT07361497 on ClinicalTrials.gov ↗
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Priya Life Science (2026). Clinical Trials in the UK Tracker. Available at: https://priyalifescience.com/clinical-trials-uk (Accessed: 11 September 2026).

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Source: ClinicalTrials.gov, U.S. National Library of Medicine — industry-sponsored studies in a recruiting status with at least one UK site, most recently updated first, refreshed daily. This is a curated slice of the registry, not every UK trial; UK studies may also be registered on ISRCTN. Listing here is informational and not medical advice; eligibility is determined by each study team. Patients should discuss participation with their clinician. Compare pay for the teams running these studies in our UK Pharma Salary Guide, or see our Ireland, EU and USA trackers.