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Updated 26 Aug 2026 · ClinicalTrials.gov

Clinical Trials in the UK

The most recently updated industry-sponsored clinical trials recruiting across the United Kingdom — searchable by condition, sponsor, phase and city. Refreshed daily from the ClinicalTrials.gov registry.

125
Recruiting now
160
Studies tracked
134
Cities with sites
Recruiting Phase 3
Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS
Amyotrophic Lateral Sclerosis
Prilenia · started 2026-02-01
📍 London · Stoke-on-Trent
NCT07322003 on ClinicalTrials.gov ↗
Active Phase 2
Study to Evaluate Tulisokibart for Hidradenitis Suppurativa (MK-7240-012)
Hidradenitis Suppurativa
Merck Sharp & Dohme LLC · started 2025-06-09
📍 Dudley · London
NCT06956235 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy
Age-related Macular Degeneration (AMD), Geographic Atrophy (GA)
Regeneron Pharmaceuticals · started 2024-10-30
📍 Liverpool · York · Bristol · London · Newcastle upon Tyne
NCT06541704 on ClinicalTrials.gov ↗
Recruiting
BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT
Hypertension, Hypertension, Systolic, Hypertension, Essential
Orchestra BioMed, Inc · started 2023-12-27
📍 London · Oxford · Southhampton
NCT06059638 on ClinicalTrials.gov ↗
Recruiting Phase 3
Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC
Prostate Cancer
Novartis Pharmaceuticals · started 2025-07-01
📍 Sutton · London
NCT06855277 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
A Study to Compare the Combination of Navlimetostat (BMS-986504) With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion
Metastatic Non-small Cell Lung Cancer With MTAP Deletion
Bristol-Myers Squibb · started 2026-01-02
📍 Leicester · London
NCT07063745 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer
Metastatic Colorectal Cancer
AbbVie · started 2025-04-24
📍 London · Oxford · Sutton · Manchester
NCT06820463 on ClinicalTrials.gov ↗
Active
Anatomical Shoulder Domelock System Study
Avascular Necrosis, Revision Surgery, Conditions Consequent to Earlier Operations, Arthritis, Rheumatoid
Zimmer Biomet · started 2017-09-28
📍 Derby
NCT03312465 on ClinicalTrials.gov ↗
Active Phase 3
A Study to Evaluate the Long-Term Safety and Efficacy of Povorcitinib in Participants With Moderate to Severe Hidradenitis Suppurativa
Hidradenitis Suppurativa (HS)
Incyte Corporation · started 2024-01-30
📍 Birmingham · Dudley · Salford
NCT06212999 on ClinicalTrials.gov ↗
Starting soon Phase 3
A Study to Evaluate Effect of AZD6234 in Adult Participants With Type 2 Diabetes Mellitus and Obesity or Overweight
Obesity or Overweight, Diabetes Mellitus, Type 2
AstraZeneca · started 2026-08-21
📍 Chippenham · Corby · Dunfermline · Hull · Northwood
NCT07784270 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)
Rheumatoid Arthritis
Hoffmann-La Roche · started 2025-12-05
📍 Leicester · Doncaster · Newcastle upon Tyne · Barnet
NCT07137598 on ClinicalTrials.gov ↗
Active Phase 1
Study of TSR-042, an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody, in Participants With Advanced Solid Tumors
Neoplasms
Tesaro, Inc. · started 2016-03-07
📍 Newcastle upon Tyne · Aberdeen · London · Manchester · Oxford
NCT02715284 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease
Graves' Disease
Immunovant Sciences GmbH · started 2025-06-19
📍 Cornwell · London · Merthyr Tydfil · Salford · Surrey
NCT07018323 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer
Mirati Therapeutics Inc. · started 2020-12-02
📍 Birmingham · Edinburgh · Kent · Leicester · London
NCT04613596 on ClinicalTrials.gov ↗
Recruiting Phase 3
Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)
Pancreatic Cancer, PDAC, PDAC - Pancreatic Ductal Adenocarcinoma, Resectable Pancreatic Ductal Adenocarcinoma (PDAC)
Revolution Medicines, Inc. · started 2025-12-15
📍 Birmingham · Glasgow · London · Manchester
NCT07252232 on ClinicalTrials.gov ↗
Active Phase 2
Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
Breast Cancer, Cholangiocarcinoma, Colorectal Cancer, Head and Neck Neoplasms
Hoffmann-La Roche · started 2015-11-19
📍 Cambridge · London · Manchester
NCT02568267 on ClinicalTrials.gov ↗
By invitation
Recovery and Early Sleep Tracking Using the SuperPatch REM Patch
Shift Work Sleep Disorder, Shift Work Type Circadian Rhythm Sleep Disorder, Shift Work Sleep Disorders
SuperPatch Limited LLC · started 2026-05-15
📍 Birmingham
NCT07785960 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256)
Chronic Graft-versus-host-disease
Incyte Corporation · started 2026-05-20
📍 Birmingham · Cambridge · Glasgow · Leeds · London
NCT07124078 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study of AIR-001 in Adults With Alpha-1 Antitrypsin Deficiency (AATD)
Alpha 1 Antitrypsin Deficiency
AIRNA Corporation · started 2026-03-17
📍 Cambridge · London · Southampton
NCT07431112 on ClinicalTrials.gov ↗
Active Phase 2
A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Biliary Cholangitis
Primary Biliary Cholangitis, PBC
Mirum Pharmaceuticals, Inc. · started 2021-09-22
📍 Southampton · Birmingham · Belfast · London · Newcastle upon Tyne
NCT05050136 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)
PIK3CA-Related Overgrowth Spectrum (PROS), Lymphatic Malformations, Vascular Malformations, PIK3CA Mutation
Relay Therapeutics, Inc. · started 2025-06-13
📍 London
NCT06789913 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer
Metastatic Breast Cancer
Hoffmann-La Roche · started 2023-09-08
📍 Belfast · Blackpool · Colchester, Essex · Northwood · Nottingham
NCT05894239 on ClinicalTrials.gov ↗
Active Phase 3
Acalabrutinib, Obinutuzumab and Chlorambucil in Treatment naïve CLL
Chronic Lymphocytic Leukemia
Acerta Pharma BV · started 2015-06-26
📍 Bournemouth · Cambridge · Leeds · Leicester · London
NCT02475681 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study to Evaluate Safety, Pharmacokinetics, and Activity of GDC-7035 as a Single Agent and in Combination in Patients With Advanced Solid Tumors
Solid Tumor
Genentech, Inc. · started 2024-11-14
📍 Edinburgh · London · Manchester · Sutton
NCT06619587 on ClinicalTrials.gov ↗
Recruiting Phase 1
An Open-label Study of AZD0120 in Adults With Multiple Sclerosis
Multiple Sclerosis
AstraZeneca · started 2025-12-09
📍 Cambridge · London
NCT07224373 on ClinicalTrials.gov ↗
Active Phase 3
A Study of Atezolizumab With Lenvatinib or Sorafenib Versus Lenvatinib or Sorafenib Alone in Hepatocellular Carcinoma Previously Treated With Atezolizumab and Bevacizumab
Unresectable Hepatocellular Carcinoma
Hoffmann-La Roche · started 2021-04-26
📍 Birmingham · Liverpool · London · Manchester · Newcastle upon Tyne
NCT04770896 on ClinicalTrials.gov ↗
Active
A Study About Antibody Levels and Biomarkers in the Blood in People With Late-onset Pompe Disease
Pompe Disease (Late-onset)
Astellas Gene Therapies · started 2024-02-01
📍 Cambridge · Newcastle upon Tyne · Salford
NCT06150820 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Pitolisant in Patients With Prader-Willi Syndrome
Prader-Willi Syndrome
Harmony Biosciences Management, Inc. · started 2024-05-28
📍 Cambridge · Hull · Dundee · Edinburgh
NCT06366464 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)
Non-Small Cell Lung Cancer
Bristol-Myers Squibb · started 2025-11-05
📍 Glasgow · London · Sulton, Surrey
NCT07100080 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
Study to Evaluate Switching to Brelovitug for the Treatment of CHD in Participants Receiving Bulevirtide
Chronic Hepatitis D
Mirum Pharmaceuticals, Inc. · started 2026-02-26
📍 Cottingham · Cardiff · London · Manchester
NCT07454837 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk Children and Adults
Diabetes Mellitus, Type 1
Eli Lilly and Company · started 2026-01-12
📍 Birmingham · Cambridge · Cardiff · Glasgow · London
NCT07222137 on ClinicalTrials.gov ↗
Recruiting
A Non-interventional Study of Participants With BPDCN Treated With Chemotherapy
Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
Stemline Therapeutics, Inc. · started 2025-10-17
📍 London · Oxford
NCT07785180 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Trial Evaluating Brelovitug (BJT-778) vs Bulevirtide for the Treatment of Chronic Hepatitis Delta Infection (AZURE-2)
Chronic Hepatitis D Infection
Mirum Pharmaceuticals, Inc. · started 2025-08-27
📍 Birmingham · London · Manchester · Cottingham
NCT07200908 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Pasritamig With or Without JNJ-87189401 Versus Placebo for Late Line Metastatic Castration-resistant Prostate Cancer (mCRPC)
Metastatic Castration-resistant Prostatic Neoplasms
Janssen Research & Development, LLC · started 2025-09-02
📍 Birmingham · London · Manchester · Sutton
NCT07164443 on ClinicalTrials.gov ↗
Active
SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases
Medtronic Vascular · started 2021-10-20
📍 Oxford
NCT05198674 on ClinicalTrials.gov ↗
Recruiting Phase 3
Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC
Non-small Cell Lung Cancer, Anaplastic Lymphoma Kinase-positive
Nuvalent Inc. · started 2025-07-17
📍 Cambridge · Guildford · Hampstead · London · Maidstone
NCT06765109 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease
Graves' Disease
Immunovant Sciences GmbH · started 2024-12-17
📍 Birmingham · Bristol · Coventry · London · Cambridge
NCT06727604 on ClinicalTrials.gov ↗
Recruiting Phase 3
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
Solid Tumors, Hematologic Malignancies
Merck Sharp & Dohme LLC · started 2018-08-21
📍 Aberdeen · Cambridge · Edinburgh · Manchester · Sheffield
NCT03486873 on ClinicalTrials.gov ↗
Active Phase 4
Benralizumab Airway Remodeling Study in Severe Eosinophilic Asthmatics
Asthma
AstraZeneca · started 2019-10-08
📍 Cambridge · Headington · Leicester · Liverpool · London
NCT03953300 on ClinicalTrials.gov ↗
Active Phase 2
A Study to Learn About the Study Medicine (Called PF-07868489) in People With Pulmonary Arterial Hypertension Who Have Previously Participated in a Clinical Study With PF-07868489
Pulmonary Hypertension
Pfizer · started 2025-11-10
📍 London
NCT07073820 on ClinicalTrials.gov ↗
Active Phase 3
A Study to Evaluate Axatilimab Versus Best Available Therapy in Participants With Chronic Graft Versus Host Disease After at Least 2 Prior Lines of Systemic Therapy
Chronic Graft-versus-host-disease
Incyte Corporation · started 2025-06-04
📍 Cardiff · Glasgow · Leeds · Leicester · London
NCT06821542 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)
Breast Neoplasms, Triple Negative Breast Neoplasms, HR Low-Positive/HER2-Negative Breast Neoplasms
Merck Sharp & Dohme LLC · started 2025-06-30
📍 London · Dundee · Huddersfield · Colchester · Orpington
NCT06966700 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study to Find Out How Nusinersen is Processed in the Body When Given Through the ThecaFlex DRx™ System in Adult and Pediatric Participants With Spinal Muscular Atrophy (PIERRE-PK)
Muscular Atrophy, Spinal
Biogen · started 2025-01-16
📍 Sheffield
NCT06555419 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) to Treat Urothelial Cancer (MK-2870-031)
Bladder Cancer
Merck Sharp & Dohme LLC · started 2026-04-23
📍 Cambridge
NCT07419295 on ClinicalTrials.gov ↗
Recruiting Phase 1
Investigating the Effect of Itraconazole on the Pharmacokinetics of AZD4144 in Healthy Participants
Healthy
AstraZeneca · started 2026-07-30
📍 Harrow
NCT07685600 on ClinicalTrials.gov ↗
Recruiting Phase 3
Extension Study for Participants in Studies That Include Belzutifan (MK-6482-043/LITESPARK-043)
Von Hippel-Lindau Disease, Malignant Neoplasms
Merck Sharp & Dohme LLC · started 2026-03-23
📍 Glasgow · London · Manchester
NCT07405164 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)
Ulcerative Colitis, Ulcerative Colitis Chronic, Inflammatory Bowel Diseases, Crohn's Disease
Eli Lilly and Company · started 2021-05-26
📍 London · Oxford · Sheffield
NCT04844606 on ClinicalTrials.gov ↗
Recruiting Phase 3
BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies
Healthy
Pfizer · started 2025-08-25
📍 Bristol · London · Truro · Southampton · Manchester
NCT07160244 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Clinical Study of Belzutifan (MK-6482) and Zanzalintinib in People With Renal Cell Carcinoma (RCC) (LITESPARK-034/LS-034/MK-6482-034)
Carcinoma, Renal Cell
Merck Sharp & Dohme LLC · started 2026-04-09
📍 Withington
NCT07489495 on ClinicalTrials.gov ↗
Recruiting Phase 4
A Study to Investigate the Effect of Budesonide/Glycopyrronium/Formoterol Fumarate Metered Dose Inhaler (BGF MDI) Compared With Placebo MDI on Heart and Lung Function in Participants With Chronic Obstructive Pulmonary Disease (COPD) and Hyperinflation
Chronic Obstructive Pulmonary Disease, Hyperinflation
AstraZeneca · started 2025-11-24
📍 Harefield · London · Manchester
NCT07073950 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)
Macular Degeneration, Age-Related Macular Degeneration, Choroidal Neovascularization, Wet Macular Degeneration
EyeBiotech Ltd. · started 2026-03-27
📍 Leicester · London
NCT07440225 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Phase 3 Study to Evaluate the Safety and Efficacy of AOC 1044 (Also Referred to as Delpacibart Zotadirsen) in Participants With DMD With Gene Mutations Amenable to Exon 44 Skipping
Muscular Dystrophies, Muscular Dystrophies (Duchenne, Becker, Myotonic Dystrophy), Muscular Disorders, Atrophic, Muscular Disease
Avidity Biosciences, Inc. · started 2026-08
📍 Newcastle
NCT07587242 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
Obesity, Overweight
Eli Lilly and Company · started 2024-11-18
📍 Barnsley · Dundee · Hull
NCT06672939 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)
Malignant Neoplasm
Merck Sharp & Dohme LLC · started 2025-08-11
📍 East Sussex · Truro · London · Edinburgh · Birmingham
NCT06979596 on ClinicalTrials.gov ↗
Recruiting Phase 3
Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)
Prostate Cancer Metastatic
Merck Sharp & Dohme LLC · started 2023-12-31
📍 Cambridge · Truro · Glasgow · London · Manchester
NCT06136624 on ClinicalTrials.gov ↗
Recruiting Phase 2
Obe-cel in Severe, Refractory Systemic Lupus Erythematosus (SLE) With Active Lupus Nephritis (LN)
Lupus Nephritis
Autolus Limited · started 2026-01-16
📍 Birmingham · Bristol · Cambridge · Edinburgh · Glasgow
NCT07053800 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event
Cardiovascular Disease
AstraZeneca · started 2025-06-04
📍 Birmingham · Bournemouth · Bridgend · Bristol · Calow
NCT07000357 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of LY4005130 in Adult Participants With Severe Alopecia Areata (Hair Loss)
Alopecia Areata
Eli Lilly and Company · started 2026-04-14
📍 London · Salford
NCT07533006 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Assess the Efficacy and Safety of Debio 4126 in Participants With Acromegaly Previously Treated With Somatostatin Analogs
Acromegaly
Debiopharm International SA · started 2025-11-26
📍 Birmingham · Leeds
NCT06930625 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet Syndrome
Dravet Syndrome
Stoke Therapeutics, Inc · started 2025-06-04
📍 Glasgow · London · Sheffield
NCT06872125 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease
Crohn's Disease
Eli Lilly and Company · started 2024-03-13
📍 Edinburgh · Headington · London · Manchester · Sheffield
NCT05509777 on ClinicalTrials.gov ↗
Recruiting Phase 2
Study of ABBV-142 to Assess Adverse Events and Change in Disease Activity in Adult Participants With Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis
AbbVie · started 2026-01-23
📍 Cambridge · Edinburgh · London · Southampton · Norwich
NCT07230288 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.
Metastatic Castration-Resistant Prostate Cancer
Pfizer · started 2024-10-22
📍 Blackburn · Chelmsford · Derby · Glasgow · Metropolitan Borough of Wirral
NCT06629779 on ClinicalTrials.gov ↗
Active
PASS of Paediatric Patients Initiating Selumetinib
Neurofibromatosis Type 1
AstraZeneca · started 2022-05-23
📍 London · Manchester · Newcastle upon Tyne
NCT05388370 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy in Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma
Metastatic Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
BeOne Medicines · started 2025-08-27
📍 Cambridge · Dundee · Metropolitan Borough of Wirral
NCT07043400 on ClinicalTrials.gov ↗
Active
A Study to Learn About the Effectiveness of Etrasimod in People With Ulcerative Colitis
Colitis, Ulcerative
Pfizer · started 2024-05-08
📍 Glasgow · Nottingham · Oxford · Edinburgh · Crumpsall
NCT06294925 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Constipation (IBS-C)
Irritable Bowel Syndrome, Constipation
Eli Lilly and Company · started 2026-04-29
📍 Cheadle · Hounslow · Macclesfield · Newcastle upon Tyne · Newquay
NCT07545772 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
Metastatic Solid Tumor, Recurrent Solid Tumor, Advanced Solid Tumor, Urinary Bladder Neoplasm
Eli Lilly and Company · started 2024-07-01
📍 London · Manchester
NCT06465069 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
Cachexia, Metastatic Pancreatic Ductal Adenocarcinoma
Pfizer · started 2025-10-03
📍 Cambridge · London · Edinburgh · Liverpool
NCT06989437 on ClinicalTrials.gov ↗
Recruiting
BoStOn SCientific Rhythm MAnagemenT REgiStry
Cardiac Disease
Boston Scientific Corporation · started 2021-03-31
📍 London · Manchester
NCT04823663 on ClinicalTrials.gov ↗
Starting soon
An Investigation Into Dielectric Testing for the Evaluation and Characterisation of Breast Tissue Using a Novel Time-Domain Bioimpedance Tool
Breast Cancer, Breast - Female
Zedsen Limited · started 2026-09
📍 London
NCT07782814 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)
Endometrial Cancer
Merck Sharp & Dohme LLC · started 2025-05-22
📍 East Sussex · Cambridge · Glasgow · London · Edinburgh
NCT06952504 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Eli Lilly and Company · started 2024-04-29
📍 Bristol · Chelsea · Great Yarmouth · London · Newcastle upon Tyne
NCT06338995 on ClinicalTrials.gov ↗
Recruiting Phase 1
A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease
Alzheimer Disease
Eli Lilly and Company · started 2024-08-15
📍 London · Sheffield · Southampton
NCT06297590 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis
Ulcerative Colitis
AbbVie · started 2025-07-28
📍 Cambridge · Sheffield · Liverpool
NCT07071519 on ClinicalTrials.gov ↗
Active Phase 3
The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
Eli Lilly and Company · started 2024-04-30
📍 Aberdeen · Birmingham · Bromborough · Coventry · Glasgow
NCT06383390 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib
Myelofibrosis, Anemia
Takeda · started 2026-09-02
📍 Lincoln · Leicester · London · Sunderland · Birmingham
NCT07623161 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Learn About the Study Medicine Elranatamab Alone and With Daratumumab in People With Multiple Myeloma Who Have Received Other Treatments
Multiple Myeloma
Pfizer · started 2021-10-04
📍 Bournemouth · Oxford · Cardiff · Bristol · Canterbury
NCT05020236 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)
Metastatic Castration-resistant Prostate Cancer (mCRPC), Prostatic Neoplasms
Merck Sharp & Dohme LLC · started 2023-12-18
📍 Cambridge · Derby · Torquay · Northwood · Truro
NCT06136650 on ClinicalTrials.gov ↗
Active Phase 2
Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer
Hepatocellular Carcinoma, Biliary Tract Cancer
AstraZeneca · started 2023-04-24
📍 Cambridge · London · Manchester
NCT05775159 on ClinicalTrials.gov ↗
Recruiting Phase 3
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients
Non-Small Cell Lung Cancer
Summit Therapeutics · started 2023-10-26
📍 Leeds · London · Manchester
NCT05899608 on ClinicalTrials.gov ↗
Starting soon
A Postmarketing Study of LEQEMBI in United Kingdom (UK) Participants With Alzheimer's Disease (AD)
Alzheimers Disease
Eisai Limited · started 2026-08-31
📍 Edinburgh · London · Motherwell
NCT07781345 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)
Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
Merck Sharp & Dohme LLC · started 2025-04-09
📍 Cambridge · Edinburgh · Preston · London · Sutton
NCT06824467 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Baricitinib in Participants From 1 Year to Less Than 18 Years Old With Juvenile Idiopathic Arthritis
Juvenile Idiopathic Arthritis
Eli Lilly and Company · started 2019-04-05
📍 Bristol · Liverpool · London · Oxford · Sheffield
NCT03773965 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of How the Medicine Called "Etrasimod" Works in Children With the Gut Disease Called Ulcerative Colitis
Colitis, Ulcerative
Pfizer · started 2026-05-28
📍 London · Bristol · Liverpool · Sheffield
NCT07470879 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)
Breast Neoplasms
Merck Sharp & Dohme LLC · started 2025-07-21
📍 London · Leicester · Manchester
NCT07060807 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years
Chronic Migraine
AbbVie · started 2025-02-13
📍 London · Gillingham · Aberdeen · Stockport
NCT06810505 on ClinicalTrials.gov ↗
Recruiting Phase 2
SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes
Type 1 Diabetes
SAb Biotherapeutics, Inc. · started 2025-11-25
📍 Cambridge · Cardiff · Edinburgh · Liverpool · London
NCT07187531 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Tacabrutideg (BGB-16673) Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors
CLL, Chronic Lymphocytic Leukemia
BeOne Medicines · started 2025-04-10
📍 Aberdeen · Birmingham · Bournemouth · London · Southampton
NCT06846671 on ClinicalTrials.gov ↗
Active Phase 3
Determine Effectiveness of Anifrolumab In SYstemic Sclerosis (DAISY)
Systemic Sclerosis, Scleroderma
AstraZeneca · started 2023-11-08
📍 Cannock · Leeds · London · Sheffield
NCT05925803 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of Belumosudil in Children With Chronic Graft Versus Host Disease (schoolROCK)
Chronic Graft Versus Host Disease
Sanofi · started 2025-12-02
📍 Newcastle upon Tyne · London
NCT07116031 on ClinicalTrials.gov ↗
Starting soon Phase 2
A Study of Brenipatide (LY3537031) in Adult Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)
Pulmonary Disease, Chronic Obstructive
Eli Lilly and Company · started 2026-08
📍 Cheadle · Ely · Hounslow · London · Penzance
NCT07759245 on ClinicalTrials.gov ↗
Active Phase 1
AZD6244 (ARRY-142886) Solid Oral Dosage Formulation in Participants With Advanced Solid Malignancies
Tumor, Cancer
AstraZeneca · started 2007-03-08
📍 Sutton
NCT00463814 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)
Cervical Cancer
Merck Sharp & Dohme LLC · started 2026-01-19
📍 Edinburgh · Withington
NCT07216703 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine
Episodic Migraine
AbbVie · started 2023-05-01
📍 London · Gillingham · Aberdeen · Stockport
NCT05711394 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Orforglipron (LY3502970) on Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease (ATTAIN-Outcomes)
Atherosclerosis Cardiovascular Disease, Chronic Kidney Disease
Eli Lilly and Company · started 2025-12-01
📍 Birmingham · Blackpool · Bromborough · Newcastle · Newquay
NCT07241390 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Learn About the Effects of the Combination of Elranatamab, Daratumumab and Lenalidomide Compared With Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Who Are Not Candidates for Transplant
Multiple Myeloma
Pfizer · started 2022-11-10
📍 Leicester · Edinburgh · Oxford · Stoke-on-Trent · Cardiff
NCT05623020 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
BeOne Medicines · started 2025-06-11
📍 Bournemouth · Headington · Leeds · London · Metropolitan Borough of Wirral
NCT06943872 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Diarrhea (IBS-D)
Irritable Bowel Syndrome, Diarrhea
Eli Lilly and Company · started 2026-05-06
📍 Cheadle · Hounslow · Macclesfield · Newcastle upon Tyne · Newquay
NCT07545759 on ClinicalTrials.gov ↗
Recruiting Phase 3
MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)
Multiple Myeloma
Pfizer · started 2024-02-08
📍 Milton Keynes · Bodelwyddan · Bournemouth · Poole · Eastbourne
NCT06152575 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis
Eli Lilly and Company · started 2023-12-21
📍 Aberdeen · Dundee · Huddersfield · Leeds · Manchester
NCT06119581 on ClinicalTrials.gov ↗
Recruiting Phase 3
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
Carcinoma, Non-Small-Cell Lung
Eli Lilly and Company · started 2025-03-27
📍 Birmingham · East Sussex · Huddersfield · London · Manchester
NCT06890598 on ClinicalTrials.gov ↗
Recruiting Phase 1
Safety, Pharmacokinetics, and Preliminary Efficacy of VIR-5500 (AMX-500) in Prostate Cancer
Hormone-refractory Prostate Cancer
Astellas Pharma Global Development, Inc. · started 2023-08-10
📍 London
NCT05997615 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of TYRA-300 in Children With Achondroplasia: BEACH301
Achondroplasia
Tyra Biosciences, Inc · started 2025-03-04
📍 London · Sheffield
NCT06842355 on ClinicalTrials.gov ↗
Recruiting Phase 1
Study of Lunresertib Alone or in Combination With RP-3500 or Debio 0123 in Patients With Advanced Solid Tumors
Advanced Solid Tumor
Debiopharm International SA · started 2021-04-30
📍 London
NCT04855656 on ClinicalTrials.gov ↗
Active Phase 3
A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)
Atherosclerotic Cardiovascular Disease (ASCVD), Elevated Lp(a)
Eli Lilly and Company · started 2024-03-05
📍 Blackpool · Bristol · Cheadle · Enfield · Glasgow
NCT06292013 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of Zasocitinib (TAK-279) in Adults With Active Crohn's Disease
Crohn's Disease
Takeda · started 2026-08-13
📍 Oxford
NCT07403968 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
Obesity, Overweight
Eli Lilly and Company · started 2024-11-18
📍 Barnsley · Bristol · Cambridge · Dundee · Harrow
NCT06672549 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma
Relapsed/Refractory Multiple Myeloma
BeOne Medicines · started 2021-09-16
📍 Headington · London · Sutton · Truro
NCT04973605 on ClinicalTrials.gov ↗
Active Phase 3
A Phase-3, Open-Label, Randomized Study of Dato-DXd Versus Investigator's Choice of Chemotherapy (ICC) in Participants With Inoperable or Metastatic HR-Positive, HER2-Negative Breast Cancer Who Have Been Treated With One or Two Prior Lines of Systemic Chemotherapy (TROPION-Breast01)
Breast Cancer
AstraZeneca · started 2021-10-18
📍 Blackpool · Bristol · Cardiff · Colchester · Edinburgh
NCT05104866 on ClinicalTrials.gov ↗
Recruiting Phase 3
Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)
Triple-Negative Breast Cancer
Merck Sharp & Dohme LLC · started 2024-06-24
📍 Bristol · Truro · London · Edinburgh · Leeds
NCT06393374 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)
Metabolic Dysfunction-Associated Steatotic Liver Disease
Eli Lilly and Company · started 2025-10-15
📍 Aberdeen · Clifton · Enfield · Glasgow · Ipswich
NCT07165028 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases
Systemic Lupus Erythematosus, Active Refractory Rheumatoid Arthritis
Amgen · started 2025-07-16
📍 Cambridge · Edinburgh · Leicester · Newcastle upon Tyne
NCT06570798 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide
Type 2 Diabetes
Eli Lilly and Company · started 2025-03-28
📍 Birmingham · Blackpool · Bristol · Bromborough · Newcastle
NCT06897475 on ClinicalTrials.gov ↗
Active Phase 3
Open-label, Long-term Safety Study of Secukinumab in Polymyalgia Rheumatica (PMR)
Polymyalgia Rheumatica
Novartis Pharmaceuticals · started 2024-06-28
📍 Barnet · Wolverhampton
NCT06331312 on ClinicalTrials.gov ↗
Active Phase 1
A Study of LY3295668 Erbumine in Participants With Relapsed/Refractory Neuroblastoma
Neuroblastoma
Eli Lilly and Company · started 2020-06-11
📍 Liverpool
NCT04106219 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome
Dravet Syndrome
Encoded Therapeutics · started 2024-05-14
📍 Glasgow · London
NCT05419492 on ClinicalTrials.gov ↗
Recruiting Phase 3
Phase 3 Trial of VMX-C001 vs Usual Pharmacological Care in Patients Taking a FXa Direct Oral Anticoagulant Who Require Urgent Surgery With or Without Heparin.
Blood Loss, Surgical, Coagulation Disorder
VarmX B.V. · started 2026-08-18
📍 Gloucester · London
NCT07288489 on ClinicalTrials.gov ↗
Active Phase 2
A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)
Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Follicular Lymphoma, Richter Transformation Lymphoma
Merck Sharp & Dohme LLC · started 2022-07-21
📍 Truro · London · Oxford · Manchester
NCT05458297 on ClinicalTrials.gov ↗
Recruiting Phase 3
Phase 3 Study of LUM-201 in Children With Growth Hormone Deficiency
Growth Hormone Deficiency (GHD)
Lumos Pharma · started 2026-05-20
📍 Liverpool · London · Sheffield
NCT06948214 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)
Castration-Resistant Prostatic Cancer, Metastasis
Merck Sharp & Dohme LLC · started 2025-07-03
📍 Cambridge · London
NCT06863272 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of Brenipatide in Participants With Opioid Use Disorder
Opioid Use Disorder
Eli Lilly and Company · started 2026-02-13
📍 Chertsey · Eastbourne · Glasgow · London · Manchester
NCT07420283 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
Heart Failure, Left Ventricular Systolic Dysfunction
Merck Sharp & Dohme LLC · started 2023-05-31
📍 London · Newcastle upon Tyne
NCT05714085 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation
Prostate Cancer
AstraZeneca · started 2025-08-06
📍 Aberdeen · Bristol · Cambridge · Edinburgh · Exeter
NCT06952803 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer
Prostate Cancer, Metastatic Castration-Resistant Prostate Cancer, Metastatic Hormone Sensitive Prostate Cancer
Astellas Pharma Global Development, Inc. · started 2025-08-19
📍 London
NCT07005154 on ClinicalTrials.gov ↗
Active Phase 1/Phase 2
A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Advanced Solid Tumors
Advanced Solid Tumors, HER2-positive Breast Cancer
Hoffmann-La Roche · started 2020-09-03
📍 Manchester · Liverpool
NCT05593094 on ClinicalTrials.gov ↗
Recruiting Phase 3
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
Osteoarthritis, Overweight or Obesity
Eli Lilly and Company · started 2026-02-09
📍 Bristol · Glasgow · London · Newcastle · Penzance
NCT07353931 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)
Non-Small Cell Lung Cancer (NSCLC)
Amgen · started 2023-11-16
📍 Birmingham · Inverness · London · Northwood · Nottingham
NCT05920356 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )
Lymphoma, Non-Hodgkin, B-cell Lymphoma, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular
Eli Lilly and Company · started 2026-05-28
📍 Leeds · Oxford
NCT07101328 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
Heart Failure
Boehringer Ingelheim · started 2025-05-20
📍 Bristol · Clydebank · Exeter · Halifax · Harrow
NCT06935370 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
Colon Adenocarcinoma, Rectal Adenocarcinoma
Merck Sharp & Dohme LLC · started 2025-07-16
📍 Birmingham · London · Oxford · Coventry · Cardiff
NCT06997497 on ClinicalTrials.gov ↗
Recruiting Phase 4
A Study of Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Chronic Lymphocytic Leukemia, Lymphoma, Small Lymphocytic
Eli Lilly and Company · started 2026-03-09
📍 Hull · Leeds · Newmarket
NCT07218341 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract
Carcinoma, Transitional Cell, Urinary Bladder Neoplasms, Neoplasm Metastasis
Eli Lilly and Company · started 2025-12-12
📍 Huddersfield · London · Manchester · Sheffield
NCT07218380 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
Pulmonary Arterial Hypertension
Merck Sharp & Dohme LLC · started 2021-05-12
📍 Cambridge · Glasgow · London · Newcastle upon Tyne · Sheffield
NCT07218029 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)
Prostate Cancer, Prostatic Neoplasms
Merck Sharp & Dohme LLC · started 2025-05-13
📍 Cambridge · London · Exeter · Birmingham · Northwood
NCT06925737 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
An Open-label Dose Escalation and Expansion, Followed by a Phase II Study of Tulmimetostat (DZR123) and JSB462 (Luxdegalutamide) in Patients With Progressive Metastatic Castrate Resistant Prostate Cancer (mCRPC) (TulmiSTAR-01)
Progressive Metastatic Castrate Resistant Prostate Cancer
Novartis Pharmaceuticals · started 2025-10-15
📍 Sutton · London
NCT07206056 on ClinicalTrials.gov ↗
By invitation
Blood Testing at Entia
Healthy, Blood Cell Count
Entia Ltd · started 2021-10-22
📍 London
NCT05580055 on ClinicalTrials.gov ↗
Active Phase 3
Roll-over Study to Collect and Assess Long-term Safety of Everolimus in Patients With TSC and Refractory Seizures Who Have Completed the EXIST-3 Study [CRAD001M2304] and Who Are Benefitting From Continued Treatment
Tuberous Sclerosis Complex
Novartis Pharmaceuticals · started 2017-08-23
📍 Birmingham · Buckinghamshire · Cambridge · Liverpool · London
NCT02962414 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Clinical Study of Calderasib (MK-1084) in People With Advanced Solid Tumors (MK-1084-014)
Neoplasm Malignant
Merck Sharp & Dohme LLC · started 2025-12-04
📍 London · Manchester
NCT07209111 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
Relapsed or Refractory Multiple Myeloma
Celgene · started 2022-09-20
📍 Cambridge · Truro · Airdrie · London · Leicester
NCT05519085 on ClinicalTrials.gov ↗
Active Phase 1/Phase 2
Study of EN-374 Gene Therapy in Participants With X-Linked Chronic Granulomatous Disease
X-Linked Chronic Granulomatous Disease
Ensoma · started 2025-08-05
📍 London
NCT06876363 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)
Lymphoma, Large B-Cell, Diffuse
Merck Sharp & Dohme LLC · started 2025-04-11
📍 Bristol · Aylesbury · Exeter · Plymouth · Middlesbrough
NCT06890884 on ClinicalTrials.gov ↗
Active Phase 3
Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury
Lower Limb or Combined Lower Limb and Upper Limb Spasticity Due to Stroke or Traumatic Brain Injury
Merz Pharmaceuticals GmbH · started 2019-09-16
📍 Cambridge · Exeter · Liverpool
NCT03992404 on ClinicalTrials.gov ↗
Recruiting Phase 3
Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
Ulcerative Colitis, Obesity or Overweight
Eli Lilly and Company · started 2025-06-26
📍 Bristol · Dundee · Exeter · London
NCT06937086 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus
Systemic Lupus Erythematosus
UCB Biopharma SRL · started 2024-11-21
📍 Bath · Belfast · Leeds · London · Newcastle upon Tyne
NCT06617325 on ClinicalTrials.gov ↗
Active
CGM Use in Adults With Type 2 Diabetes on Basal Insulin
Diabetes Mellitus, Type 2
Abbott Diabetes Care · started 2023-07-14
📍 Ashton-under-Lyne · Bath · Birmingham · Cambridge · Darlington
NCT05944432 on ClinicalTrials.gov ↗
Recruiting Phase 3
EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)
Kidney Disease, Chronic
Boehringer Ingelheim · started 2024-08-30
📍 Antrim · Basildon · Belfast · Birmingham · Blackburn
NCT06531824 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine
Chronic Migraine
Merz Therapeutics GmbH · started 2025-08-21
📍 Stoke-on-Trent
NCT07018713 on ClinicalTrials.gov ↗
Recruiting Phase 3
Long-Term Safety Study of Deucravacitinib Versus Ustekinumab in Participants With Psoriasis (PRAGMATYK)
Plaque Psoriasis
Bristol-Myers Squibb · started 2025-09-22
📍 London · Southampton · Salford · Bristol · High Wycombe
NCT07116967 on ClinicalTrials.gov ↗
Recruiting Phase 3
ATSN-201 Gene Therapy in RS1-Associated X-linked Retinoschisis
X-linked Retinoschisis
Atsena Therapeutics Inc. · started 2023-08-22
📍 Oxford
NCT05878860 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions
Myelodysplastic Syndromes
Takeda · started 2025-05-06
📍 Aberdeen · Rhyl · Leicester · High Heaton · Sunderland
NCT06499285 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)
Non-small Cell Lung Cancer
Merck Sharp & Dohme LLC · started 2025-10-08
📍 Truro · London · Birmingham · Leicester
NCT07190248 on ClinicalTrials.gov ↗
Recruiting Phase 3
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
Metastatic Colorectal Cancer
Amgen · started 2024-07-17
📍 Birmingham · Glasgow · London · Maidstone · Northwood
NCT06252649 on ClinicalTrials.gov ↗
Recruiting Phase 3
LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis
Metabolic Dysfunction Associated Steatohepatitis
Boehringer Ingelheim · started 2024-11-12
📍 Aberdeen · Bristol · Camberley · Derby · Edgbaston, Birmingham
NCT06632457 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
Heart Failure
Boehringer Ingelheim · started 2024-06-17
📍 Barnet · Bristol · Exeter · Halifax · High Wycombe
NCT06424288 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)
DLBCL, Diffuse Large B-Cell Lymphoma
Merck Sharp & Dohme LLC · started 2022-01-14
📍 Aberdeen · Truro · London-Camden
NCT05139017 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell Malignancies
B-cell Malignancy, Marginal Zone Lymphoma, Follicular Lymphoma, Non-Hodgkin Lymphoma
BeOne Medicines · started 2021-09-13
📍 Edinburgh · Leeds · Newcastle upon Tyne · Newmarket · Norwich
NCT05006716 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
Advanced Solid Tumor, Melanoma, Head and Neck Cancer, Gastric Cancer
Daiichi Sankyo · started 2024-02-26
📍 Coventry · London · Nottingham
NCT06172478 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer
Ovarian Neoplasms, Fallopian Tube Neoplasms, Peritoneal Neoplasms, Neoplasm Metastasis
Eli Lilly and Company · started 2025-10-22
📍 Bath · Leeds · London · Manchester · Torquay
NCT07213804 on ClinicalTrials.gov ↗
Recruiting Phase 3
Beamion LUNG-3: Adjuvant Zongertinib vs Standard Treatment in People With Completely Resected Stage II-IIIB NSCLC Harboring Activating HER2 TKD Mutations
Non-small Cell Lung Cancer
Boehringer Ingelheim · started 2026-01-16
📍 Cardiff · Edinburgh · London · Manchester · Sutton
NCT07195695 on ClinicalTrials.gov ↗
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Priya Life Science (2026). Clinical Trials in the UK Tracker. Available at: https://priyalifescience.com/clinical-trials-uk (Accessed: 26 August 2026).

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Source: ClinicalTrials.gov, U.S. National Library of Medicine — industry-sponsored studies in a recruiting status with at least one UK site, most recently updated first, refreshed daily. This is a curated slice of the registry, not every UK trial; UK studies may also be registered on ISRCTN. Listing here is informational and not medical advice; eligibility is determined by each study team. Patients should discuss participation with their clinician. Compare pay for the teams running these studies in our UK Pharma Salary Guide, or see our Ireland, EU and USA trackers.