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Updated 26 Aug 2026 · ClinicalTrials.gov

Clinical Trials in Sheffield

← All UK trials

The most recently updated industry-sponsored clinical trials recruiting across the United Kingdom — searchable by condition, sponsor, phase and city. Refreshed daily from the ClinicalTrials.gov registry.

19
Recruiting now
21
Studies tracked
Sheffield
Selected city
Recruiting Phase 2
A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256)
Chronic Graft-versus-host-disease
Incyte Corporation · started 2026-05-20
📍 Birmingham · Cambridge · Glasgow · Leeds · London
NCT07124078 on ClinicalTrials.gov ↗
Recruiting Phase 3
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
Solid Tumors, Hematologic Malignancies
Merck Sharp & Dohme LLC · started 2018-08-21
📍 Aberdeen · Cambridge · Edinburgh · Manchester · Sheffield
NCT03486873 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study to Find Out How Nusinersen is Processed in the Body When Given Through the ThecaFlex DRx™ System in Adult and Pediatric Participants With Spinal Muscular Atrophy (PIERRE-PK)
Muscular Atrophy, Spinal
Biogen · started 2025-01-16
📍 Sheffield
NCT06555419 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)
Ulcerative Colitis, Ulcerative Colitis Chronic, Inflammatory Bowel Diseases, Crohn's Disease
Eli Lilly and Company · started 2021-05-26
📍 London · Oxford · Sheffield
NCT04844606 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet Syndrome
Dravet Syndrome
Stoke Therapeutics, Inc · started 2025-06-04
📍 Glasgow · London · Sheffield
NCT06872125 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease
Crohn's Disease
Eli Lilly and Company · started 2024-03-13
📍 Edinburgh · Headington · London · Manchester · Sheffield
NCT05509777 on ClinicalTrials.gov ↗
Recruiting Phase 1
A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease
Alzheimer Disease
Eli Lilly and Company · started 2024-08-15
📍 London · Sheffield · Southampton
NCT06297590 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis
Ulcerative Colitis
AbbVie · started 2025-07-28
📍 Cambridge · Sheffield · Liverpool
NCT07071519 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Baricitinib in Participants From 1 Year to Less Than 18 Years Old With Juvenile Idiopathic Arthritis
Juvenile Idiopathic Arthritis
Eli Lilly and Company · started 2019-04-05
📍 Bristol · Liverpool · London · Oxford · Sheffield
NCT03773965 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of How the Medicine Called "Etrasimod" Works in Children With the Gut Disease Called Ulcerative Colitis
Colitis, Ulcerative
Pfizer · started 2026-05-28
📍 London · Bristol · Liverpool · Sheffield
NCT07470879 on ClinicalTrials.gov ↗
Active Phase 3
Determine Effectiveness of Anifrolumab In SYstemic Sclerosis (DAISY)
Systemic Sclerosis, Scleroderma
AstraZeneca · started 2023-11-08
📍 Cannock · Leeds · London · Sheffield
NCT05925803 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis
Eli Lilly and Company · started 2023-12-21
📍 Aberdeen · Dundee · Huddersfield · Leeds · Manchester
NCT06119581 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of TYRA-300 in Children With Achondroplasia: BEACH301
Achondroplasia
Tyra Biosciences, Inc · started 2025-03-04
📍 London · Sheffield
NCT06842355 on ClinicalTrials.gov ↗
Recruiting Phase 3
Phase 3 Study of LUM-201 in Children With Growth Hormone Deficiency
Growth Hormone Deficiency (GHD)
Lumos Pharma · started 2026-05-20
📍 Liverpool · London · Sheffield
NCT06948214 on ClinicalTrials.gov ↗
Recruiting Phase 3
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
Osteoarthritis, Overweight or Obesity
Eli Lilly and Company · started 2026-02-09
📍 Bristol · Glasgow · London · Newcastle · Penzance
NCT07353931 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract
Carcinoma, Transitional Cell, Urinary Bladder Neoplasms, Neoplasm Metastasis
Eli Lilly and Company · started 2025-12-12
📍 Huddersfield · London · Manchester · Sheffield
NCT07218380 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
Pulmonary Arterial Hypertension
Merck Sharp & Dohme LLC · started 2021-05-12
📍 Cambridge · Glasgow · London · Newcastle upon Tyne · Sheffield
NCT07218029 on ClinicalTrials.gov ↗
Active Phase 3
Roll-over Study to Collect and Assess Long-term Safety of Everolimus in Patients With TSC and Refractory Seizures Who Have Completed the EXIST-3 Study [CRAD001M2304] and Who Are Benefitting From Continued Treatment
Tuberous Sclerosis Complex
Novartis Pharmaceuticals · started 2017-08-23
📍 Birmingham · Buckinghamshire · Cambridge · Liverpool · London
NCT02962414 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus
Systemic Lupus Erythematosus
UCB Biopharma SRL · started 2024-11-21
📍 Bath · Belfast · Leeds · London · Newcastle upon Tyne
NCT06617325 on ClinicalTrials.gov ↗
Recruiting Phase 3
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
Metastatic Colorectal Cancer
Amgen · started 2024-07-17
📍 Birmingham · Glasgow · London · Maidstone · Northwood
NCT06252649 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
Heart Failure
Boehringer Ingelheim · started 2024-06-17
📍 Barnet · Bristol · Exeter · Halifax · High Wycombe
NCT06424288 on ClinicalTrials.gov ↗
No trials match your search.

Browse by city

London · 111 Manchester · 39 Cambridge · 36 Birmingham · 32 Glasgow · 25 Bristol · 23 Edinburgh · 23 Oxford · 22 Sheffield · 21 Newcastle upon Tyne · 20 Leicester · 17 Liverpool · 16 Leeds · 16 Sutton · 13 Truro · 13 Aberdeen · 12

Browse by condition

Chronic Lymphocytic Leukemia · 5 Prostate Cancer · 4 Breast Cancer · 3 Non-small Cell Lung Cancer · 3 Healthy · 3 Ulcerative Colitis · 3 Crohn's Disease · 3 Advanced Solid Tumor · 3 Multiple Myeloma · 3 Neoplasm Metastasis · 3 Heart Failure · 3 Hypertension · 2 Metastatic Colorectal Cancer · 2 Obesity or Overweight · 2 Diabetes Mellitus, Type 2 · 2 Graves' Disease · 2
Cite this page

Priya Life Science (2026). Clinical Trials in the UK Tracker. Available at: https://priyalifescience.com/clinical-trials-uk/city/sheffield (Accessed: 26 August 2026).

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Source: ClinicalTrials.gov, U.S. National Library of Medicine — industry-sponsored studies in a recruiting status with at least one UK site, most recently updated first, refreshed daily. This is a curated slice of the registry, not every UK trial; UK studies may also be registered on ISRCTN. Listing here is informational and not medical advice; eligibility is determined by each study team. Patients should discuss participation with their clinician. Compare pay for the teams running these studies in our UK Pharma Salary Guide, or see our Ireland, EU and USA trackers.