|
Albumin-bound Paclitaxel and Carboplatin Versus Epirubicin and Docetaxel for Triple-negative Breast Cancer
|
Phase 4 |
Recruiting |
Shengjing Hospital |
China |
A Comparison of Nab-PHP and TCbHP Efficacy in Neoadjuvant Therapy for HER2-positive Early Breast Cancer
NCT04547907 · ClinicalTrials.gov ↗ · Breast Cancer,HER2-positive
|
Phase 3 |
Recruiting |
Henan Cancer Hospital |
China |
A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
NCT04928846 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer
|
Phase 3 |
Recruiting |
AbbVie |
UK, USA, China |
Utidelone Versus Docetaxel in HER2-negative Locally Advanced or Metastatic Breast Cancer
NCT05430399 · ClinicalTrials.gov ↗ · Breast Neoplasms, Locally Advanced or Metastatic Breast Cancer
|
Phase 3 |
Recruiting |
Sun Yat-sen University |
China |
A Study of MRG002 Versus Investigator's Choice of Chemotherapy in the Treatment of Patients With HER2-positive Unresectable Advanced or Metastatic Urothelial Cancer
NCT05754853 · ClinicalTrials.gov ↗ · Advanced or Metastatic Urothelium Cancer
|
Phase 3 |
Recruiting |
Shanghai Miracogen Inc. |
China |
Study of Comparing of With and Without Sequential Therapy of S-1
NCT05813015 · ClinicalTrials.gov ↗ · Locally Advanced Gastric Adenocarcinoma, Chemotherapy Effect
|
Phase 3 |
Recruiting |
Zhejiang University |
China |
Comparing the Efficacy and Safety of Rezvilutamide+ADT+Docetaxel Versus Rezvilutamide +ADT in the mHSPC
NCT05983783 · ClinicalTrials.gov ↗ · Metastatic Prostate Cancer, Hormone Sensitive Prostate Cancer, Chemotherapy Effect
|
Phase 3 |
Recruiting |
The First Affiliated Hospital with Nanjing Medical University |
China |
|
JSKN003 Versus Treatment Of Physician'S Choice For HER2-low, Unresectable and/or Metastatic Breast Cancer Subjects
|
Phase 3 |
Recruiting |
Jiangsu Alphamab Biopharmaceuticals Co., Ltd |
China |
Evaluating the Efficacy and Safety of Pembrolizumab Plus Standard Chemotherapy in the Neoadjuvant Treatment of Local Advanced (LA) HNSCC
NCT06102395 · ClinicalTrials.gov ↗ · Head and Neck Squamous Cell Carcinoma, Neoadjuvant Therapy, Pembrolizumab
|
Phase 3 |
Recruiting |
Beijing Tongren Hospital |
China |
A Study of KC1036 Versus Investigator's Choice of Chemotherapy in Patients With Advanced Esophageal Cancer
NCT06194734 · ClinicalTrials.gov ↗ · Esophageal Squamous Cell Carcinoma
|
Phase 3 |
Recruiting |
Beijing Konruns Pharmaceutical Co., Ltd. |
China |
|
A Clinical Study of Docetaxel for Injection (Albumin-bound) in Patients With Gastric Cancer
|
Phase 3 |
Recruiting |
CSPC ZhongQi Pharmaceutical Technology Co., Ltd. |
China |
A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer
NCT06340568 · ClinicalTrials.gov ↗ · Endometrial Cancer
|
Phase 3 |
Recruiting |
BioNTech SE |
UK, USA, China |
Trial of Therapeutic Cancer Vaccine OSE2101 in Patients With Non-Small Cell Lung Cancer and Secondary Resistance to Immune Checkpoint Inhibitor
NCT06472245 · ClinicalTrials.gov ↗ · Patients With Non-Small Cell Lung Cancer
|
Phase 3 |
Recruiting |
OSE Immunotherapeutics |
UK, USA |
The Study of 177Lu-TLX591 Plus SOC Versus SOC Alone in Patients With mCRPC (ProstACT Global)
NCT06520345 · ClinicalTrials.gov ↗ · Metastatic Castration-resistant Prostate Cancer
|
Phase 3 |
Recruiting |
Telix Pharmaceuticals (Innovations) Pty Limited |
UK, USA |
A Trial to Evaluate Intravesical Nadofaragene Firadenovec Alone or in Combination With Chemotherapy or Immunotherapy in Participants With High-grade BCG Unresponsive Non-muscle Invasive Bladder Cancer
NCT06545955 · ClinicalTrials.gov ↗ · Non-muscle Invasive Bladder Cancer With Carcinoma in Situ
|
Phase 3 |
Recruiting |
Ferring Pharmaceuticals |
USA |
A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)
NCT06644781 · ClinicalTrials.gov ↗ · Esophageal Squamous Cell Carcinoma
|
Phase 3 |
Recruiting |
Daiichi Sankyo |
UK, USA, China |
A Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab in First-line Treatment of Locoregional Recurrent Squamous Cell Carcinoma of the Head and Neck With No Distant Metastases
NCT06699212 · ClinicalTrials.gov ↗ · Recurrent Head and Neck Squamous Cell Carcinoma
|
Phase 3 |
Recruiting |
Rakuten Medical, Inc. |
USA, China |
A Phase III Study of SHR-A2102 Versus Investigator-selected Therapy in Advanced Urothelial Carcinoma
NCT06738251 · ClinicalTrials.gov ↗ · Advanced Urothelial Carcinoma
|
Phase 3 |
Recruiting |
Shanghai Hengrui Pharmaceutical Co., Ltd. |
China |
|
Clinical Trial of N-803 Plus Tislelizumab or Prior Failed Immune Checkpoint Inhibitor and Docetaxel Versus Docetaxel Monotherapy in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Acquired Resistance to Immune Checkpoint In
|
Phase 3 |
Recruiting |
ImmunityBio, Inc. |
UK, USA |
A Study Comparing BL-B01D1 With Chemotherapy of Physician's Choice in Patients With Recurrent or Metastatic Urothelial Carcinoma(PANKU-Bladder01)
NCT06857175 · ClinicalTrials.gov ↗ · Urothelial Carcinoma
|
Phase 3 |
Recruiting |
Sichuan Baili Pharmaceutical Co., Ltd. |
China |
Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)
NCT06881784 · NSCLC (Non-small Cell Lung Cancer), Non-Small Cell Lung Cancer, NSCLC
|
Phase 3 |
Recruiting |
Revolution Medicines, Inc. |
Ireland, UK, USA |
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)
NCT06925737 · ClinicalTrials.gov ↗ · Prostate Cancer, Prostatic Neoplasms
|
Phase 3 |
Recruiting |
Merck Sharp & Dohme LLC |
Ireland, UK, USA, China |
|
A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)
|
Phase 3 |
Recruiting |
Merck Sharp & Dohme LLC |
Ireland, UK, USA, China |
DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer
NCT06989112 · ClinicalTrials.gov ↗ · Endometrial Cancer
|
Phase 3 |
Recruiting |
AstraZeneca |
UK, USA, China |
A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)
NCT07144280 · ClinicalTrials.gov ↗ · Non-small Cell Carcinoma, Non-Small Cell Lung Cancer Metastatic, Non-Small Cell Lung Carcinoma
|
Phase 3 |
Recruiting |
Pfizer |
UK, USA, India, China |
A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naรฏve Metastatic Castration-resistant Prostate Cancer
NCT07213674 · Metastatic Castration-resistant Prostate Cancer
|
Phase 3 |
Recruiting |
Amgen |
UK, USA |
A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer
NCT07225946 · ClinicalTrials.gov ↗ · Prostatic Neoplasms, Castration-Resistant
|
Phase 3 |
Recruiting |
Janssen Research & Development, LLC |
UK, USA, China |
JS107 vs Investigator's Choice as Second-line or Later Therapy for Advanced CLDN18.2-Positive Gastricor GEJ Adenocarcinoma.
NCT07284134 · ClinicalTrials.gov ↗ · Advanced Gastric or Gastroesophageal Junction Adenocarcinoma
|
Phase 3 |
Recruiting |
Shanghai Junshi Bioscience Co., Ltd. |
China |
Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations
NCT07291037 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer (NSCLC)
|
Phase 3 |
Recruiting |
AstraZeneca |
UK, USA, India, China |
A Phase III Trial of BNT324 Versus Docetaxel in Metastatic Castration-resistant Prostate Cancer
NCT07365995 · Metastatic Castration-resistant Prostate Cancer
|
Phase 3 |
Recruiting |
BioNTech SE |
UK, USA, China |
Adjuvant Oxaliplatin Plus S-1 Versus Docetaxel Plus S-1 for Stage III Gastric Cancer
NCT07366528 · ClinicalTrials.gov ↗ · Gastric Cancer (GC), Adjuvant Chemotherapy, Stage 3 Cancer
|
Phase 3 |
Recruiting |
Ruijin Hospital |
China |
IBI354 With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer
NCT07377643 · ClinicalTrials.gov ↗ · HER2-positive Breast Cancer
|
Phase 3 |
Recruiting |
Innovent Biopharmaceutical Technology (Hangzhou) Co., LTD. |
China |
Pivotal Study to Evaluate YL202 Versus Docetaxel in Patients With Locally Advanced or Metastatic EGFR Sensitive Mutation Non-Squamous Non-Small Cell Lung Cancer
NCT07416994 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer
|
Phase 3 |
Recruiting |
MediLink Therapeutics (Suzhou) Co., Ltd. |
China |
|
A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) to Treat Urothelial Cancer (MK-2870-031)
|
Phase 3 |
Recruiting |
Merck Sharp & Dohme LLC |
UK, USA, China |
A Phase III Study of KN026 in Combination With HB1801 as Adjuvant Therapy for Resectable HER2-Positive Breast Cancer
NCT07441460 · ClinicalTrials.gov ↗ · Resectable HER2-positive Breast Cancer
|
Phase 3 |
Recruiting |
Shanghai JMT-Bio Inc. |
China |
A Study of YL201 Versus Investigator's Choice of Chemotherapy in Participants With Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma After Failure of First-Line Therapy
NCT07487896 · ClinicalTrials.gov ↗ · Advanced Esophageal Squamous Cell Carcinoma
|
Phase 3 |
Recruiting |
MediLink Therapeutics (Suzhou) Co., Ltd. |
China |
A Study Comparing BL-M05D1 With the Investigator's Choice of Treatment Regimen in Patients With Claudin (CLDN)18.2-Positive Advanced Gastric Cancer or Gastroesophageal Junction Adenocarcinoma (GC/GEJC) Who Have Received Prior First-Line Treatment
NCT07518147 · ClinicalTrials.gov ↗ · Gastric Cancer, Gastroesophageal Junction Adenocarcinoma
|
Phase 3 |
Recruiting |
Sichuan Baili Pharmaceutical Co., Ltd. |
China |
A Study of BL-M07D1 Combined With Pertuzumab Versus Docetaxel Plus Trastuzumab and Pertuzumab in Patients With First-line HER2-positive Recurrent or Metastatic Breast Cancer
NCT07518173 · ClinicalTrials.gov ↗ · HER2-positive Breast Cancer
|
Phase 3 |
Recruiting |
Sichuan Baili Pharmaceutical Co., Ltd. |
China |
A Study to Compare Setidegrasib (ASP3082) With Docetaxel, in People With Non-small Cell Lung Cancer With a KRAS G12D Mutation
NCT07566052 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer (NSCLC)
|
Phase 3 |
Recruiting |
Astellas Pharma Global Development, Inc. |
USA, China |
Aglatimagene Besadenovec + Prodrug and Pembrolizumab vs Docetaxel for Stage IV Non-Squamous NSCLC Progressing on Pembrolizumab (AURORA)
NCT07660094 · ClinicalTrials.gov ↗ · Non-squamous, Non-Small Cell Lung Cancer
|
Phase 3 |
Recruiting |
Candel Therapeutics, Inc. |
USA |
A Study to Evaluate GFH375 Versus Docetaxel in Participants With Non-Small Cell Lung Cancer With KRAS G12D Mutation
NCT07668752 · ClinicalTrials.gov ↗ · KRAS G12D Mutation, NSCLC (Non-small Cell Lung Cancer)
|
Phase 3 |
Recruiting |
Genfleet Therapeutics (Shanghai) Inc. |
China |
A Study to Learn About the Investigational Drug Rinzimetostat (ORIC-944) in Patients With mCRPC Who Were Previously Treated With Abiraterone Acetate (Himalayas-1)
NCT07723248 · ClinicalTrials.gov ↗ · Metastatic Castration Resistant Prostate Cancer
|
Phase 3 |
Recruiting |
ORIC Pharmaceuticals |
USA |
Neoadjuvant Pyrotinib-to-pertuzumab in HER2+ eBC
NCT07797218 · ClinicalTrials.gov ↗ · Breast Cancer Early Stage Breast Cancer (Stage 1-3)
|
Phase 3 |
Recruiting |
Shanghai Jiao Tong University School of Medicine |
China |
Efficacy and Safety of Dose-dense Chemotherapy (ddEC-ddP) for Neoadjuvant Chemotherapy of HER2-negative Breast Cancer
NCT04576143 · ClinicalTrials.gov ↗ · HER2-negative Breast Cancer, Neoadjuvant Chemotherapy
|
Phase 2/3 |
Recruiting |
Second Affiliated Hospital, Zhejiang University, School of Medicine |
China |
|
KN026 in Combination With Chemotherapy in HER2 Positive Gastric Cancer Subjects Who Have Failed First-line Therapy
|
Phase 2/3 |
Recruiting |
Shanghai JMT-Bio Inc. |
China |
A Global Phase II/III Clinical Study to Evaluate the Efficacy and Safety of HLX43 Monotherapy or HLX43 in Combination With HLX07 Versus Docetaxel in Advanced or Metastatic Squamous Non-Small Cell Lung Cancer
NCT07459751 · ClinicalTrials.gov ↗ · Advanced or Metastatic Squamous Non-Small Cell Lung Cancer
|
Phase 2/3 |
Recruiting |
Shanghai Henlius Biotech |
China |
Docetaxel, Oxaliplatin and 5-FU for Gastric Cancer With Inoperable Malignant Bowel Obstruction
NCT04840264 · ClinicalTrials.gov ↗ · Metastatic Gastric Adenocarcinoma, Metastatic Gastroesophageal Junction Adenocarcinoma, Peritoneal Carcinomatosis
|
Phase 2 |
Recruiting |
Sixth Affiliated Hospital, Sun Yat-sen University |
China |
Fudan University Shanghai Cancer Center Breast Cancer Precision Platform Series Study- Neoadjuvant Therapy
NCT05582499 · ClinicalTrials.gov ↗ · Breast Neoplasm, Breast Cancer, Breast Tumors
|
Phase 2 |
Recruiting |
Fudan University |
China |
|
Pyrotinib Combined With Trastuzumab, Dalpiciclib, Letrozole Versus TCbHP (Trastuzumab Plus Pertuzumab With Docetaxel and Carboplatin) as Neoadjuvant Treatment in HR +/HER2 + Breast Cancer
|
Phase 2 |
Recruiting |
Shengjing Hospital |
China |
Comparing the Efficacy of Nab-PH+Pyrrolitinib and TCbHP in the Neoadjuvant Treatment of HER2 Positive BC
NCT05918328 · ClinicalTrials.gov ↗ · Breast Cancer, HER2-positive Breast Cancer
|
Phase 2 |
Recruiting |
Henan Cancer Hospital |
China |
A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer
NCT05999994 · ClinicalTrials.gov ↗ · Neoplasms, Child, Adolescent
|
Phase 2 |
Recruiting |
Eli Lilly and Company |
UK, USA |
|
Dalpiciclib Plus AI (Neoadjuvant Endocrine Therapy) Compared With Neoadjuvant Chemotherapy in Early Breast Cancer ๏ผEBC๏ผ
|
Phase 2 |
Recruiting |
Hebei Medical University Fourth Hospital |
China |
Phase II Clinical Trial to Evaluate the Safety and Efficacy of TQB2450 Injection Combined With Anlotinib Capsule and Chemotherapy in the Treatment of Immunoresistant Advanced Non-small Cell Lung Cancer
NCT06141226 · ClinicalTrials.gov ↗ · Non-small-cell Lung Cancer
|
Phase 2 |
Recruiting |
Tianjin Medical University Cancer Institute and Hospital |
China |
Precision Treatment of Recurrent/Metastatic Salivary Gland Carcinoma Guided by Molecular Typing
NCT06145308 · ClinicalTrials.gov ↗ · Salivary Gland Carcinoma, Precision Therapy
|
Phase 2 |
Recruiting |
Peking Union Medical College |
China |
|
The Dosing Regimen of Pyrotinib in HER2-positive Advanced First-line Breast Cancer: a Phase II Clinical Study
|
Phase 2 |
Recruiting |
The First Affiliated Hospital with Nanjing Medical University |
China |
Genomic Biomarker-guided Neoadjuvant Therapy for Prostate Cancer (SEGNO)
NCT06387056 · ClinicalTrials.gov ↗ · Locally Advanced Prostate Cancer, Oligometastatic Prostate Cancer
|
Phase 2 |
Recruiting |
The First Affiliated Hospital of Xiamen University |
China |
|
A Prospective, Single-arm, Phase II Clinical Trial to Evaluate the Efficacy and Safety of Tafolecimab and Sintilimab Combined With Chemotherapy in Patients With Advanced or Metastatic Driver Gene-negative Non-small Cell Lung Cancer After Failure of First-line Immunotherapy.
|
Phase 2 |
Recruiting |
Jinghui Wang |
China |
Efficacy & Safety of Olvimulogene Nanivacirepvec & Platinum-doublet + Physician's Choice of Immune Checkpoint Inhibitor Compared to Docetaxel in NSCL Cancer
NCT06463665 · ClinicalTrials.gov ↗ · Advanced Non-squamous Non-small-cell Lung Cancer, Advanced Squamous Non-Small Cell Lung Carcinoma, Metastatic Non-squamous Non Small Cell Lung Cancer
|
Phase 2 |
Recruiting |
Genelux Corporation |
USA |
|
An Exploratory Study of Tislelizumab in Combination with Chemotherapy in Immuno-experienced Patients with EGFR/ALK/ROS1-negative Advanced NSCLC in the Second-line Setting
|
Phase 2 |
Recruiting |
Shanghai Pulmonary Hospital, Shanghai, China |
China |
|
Substudy 01I: A Study of Investigational Agents in Participants With Previously Treated Stage IV Squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01I/KEYMAKER-U01I)
|
Phase 2 |
Recruiting |
Merck Sharp & Dohme LLC |
USA, China |
A Clinical Trial of LBL-024 Combination Drug in Patients With Advanced Solid Tumours[Substudy 01(NSCLC)]
NCT06783647 · ClinicalTrials.gov ↗ · Advanced Solid Tumour
|
Phase 2 |
Recruiting |
Nanjing Leads Biolabs Co.,Ltd |
China |
Safety and Preliminary Efficacy of Pumitamig (BNT327), an Investigational Therapy for Patients With Non-small Cell Lung Cancer in Combination With Chemotherapy as First-line or Second-line Treatment
NCT06841055 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer
|
Phase 2 |
Recruiting |
BioNTech SE |
UK, USA |
|
Evaluating the Preliminary Efficacy and Safety of JS207 in NSCLC After Progression Following Platinum-based Chemotherapy and Immunotherapy
|
Phase 2 |
Recruiting |
Shanghai Junshi Bioscience Co., Ltd. |
China |
SHR-A1811 Plus Pertuzumab in the Neoadjuvant Treatment of HER2 Positive BC
NCT06927180 · ClinicalTrials.gov ↗ · Breast Cancer Early Stage Breast Cancer (Stage 1-3)
|
Phase 2 |
Recruiting |
Henan Cancer Hospital |
China |
Trilaciclib in Combination With Docetaxel for Second-Line and Beyond Treatment of Locally Advanced or Metastatic NSCLC
NCT06929936 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer, Myelosuppression
|
Phase 2 |
Recruiting |
The First Affiliated Hospital of Xiamen University |
China |
Safety and Efficacy of Glumetinib Combined With Docetaxel for Injection (Albumin-bound) in Patients With Advanced Gastric Cancer/Gastroesophageal Junction Adenocarcinoma and Other Solid Tumors
NCT06947291 · ClinicalTrials.gov ↗ · Advanced Gastric Cancer/Gastroesophageal Junction Adenocarcinoma and Other Solid Tumors
|
Phase 2 |
Recruiting |
CSPC ZhongQi Pharmaceutical Technology Co., Ltd. |
China |
ctDNA-MRD Guided Escalation of Ivonescimab and Docetaxel in Advanced NSCLC With Long-Term Responses to First-line Immunotherapy (CR1STAL-Adaptive)
NCT06951646 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer, Immune Checkpoint Inhibitors (ICIs)
|
Phase 2 |
Recruiting |
Second Xiangya Hospital of Central South University |
China |
A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer
NCT07102381 · ClinicalTrials.gov ↗ · HER2-positive Breast Cancer, Breast Cancer
|
Phase 2 |
Recruiting |
Jazz Pharmaceuticals |
USA |
Trial Investigating Visugromab and Nivolumab With or Without Docetaxel in 2L Treatment of Participants With Metastatic NSCLC
NCT07246863 · ClinicalTrials.gov ↗ · Metastatic Non-Squamous Non-Small Cell Lung Cancer, Adult Solid Tumor
|
Phase 2 |
Recruiting |
CatalYm GmbH |
USA |
A Study to Test Inavolisib Treatment in Participants With Metastatic Castration-Resistant Prostate Cancer
NCT07287150 · Metastatic Castration-Resistant Prostate Cancer
|
Phase 2 |
Recruiting |
Hoffmann-La Roche |
UK, USA |
WAST Cell-Docetaxel Combination Therapy in PD-1 Inhibitor-Resistant Advanced NSCLC
NCT07330050 · ClinicalTrials.gov ↗ · NSCLC (Non-small Cell Lung Cancer)
|
Phase 2 |
Recruiting |
Tianjin Medical University Cancer Institute and Hospital |
China |
|
ctDNA in HER2+ EBC Neoadjuvant Treatment
|
Phase 2 |
Recruiting |
Shanghai Jiao Tong University School of Medicine |
China |
|
A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies
|
Phase 2 |
Recruiting |
Mirati Therapeutics Inc. |
UK, USA, China |
|
Evaluation of the Efficacy and Safety of Darolutamide + ADT Combined With Low-dose Docetaxel in mHSPC
|
Phase 2 |
Recruiting |
Yonghong Li |
China |
Microwave Ablation Plus Tislelizumab and Docetaxel in Advanced NSCLC After First-Line Immunotherapy Failure
NCT07528274 · ClinicalTrials.gov ↗ · NSCLC (Non-small Cell Lung Cancer), NSCLC (Advanced Non-small Cell Lung Cancer)
|
Phase 2 |
Recruiting |
Tianjin Medical University Cancer Institute and Hospital |
China |
Nimotuzumab Combined With Immunotherapy and Chemotherapy in the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma
NCT07601737 · ClinicalTrials.gov ↗ · Head and Neck Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma (HNSCC), Head & Neck Cancer
|
Phase 2 |
Recruiting |
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine |
China |
A Study of LM-168 Combined With Other Anti-tumor Treatments in Participants With Advanced Solid Tumors
NCT07669415 · ClinicalTrials.gov ↗ · Advanced Solid Tumor
|
Phase 2 |
Recruiting |
LaNova Medicines Limited |
China |
A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors
NCT04895709 · ClinicalTrials.gov ↗ · Cervical Cancer, Gastric/Gastroesophageal Junction Adenocarcinoma, Microsatellite Stable Colorectal Cancer
|
Phase 1/2 |
Recruiting |
Bristol-Myers Squibb |
USA |
Dose Escalation/Expansion Study of Mavrostobart (PT199), an Anti-CD73 mAb, Administered Alone and in Combination With a PD-1 Inhibitor or Chemotherapy (the MORNINGSTAR Study)
NCT05431270 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer, Pancreatic Ductal Adenocarcinoma
|
Phase 1/2 |
Recruiting |
Phanes Therapeutics |
USA |
|
A Study of ASKG915 in Patients With Selected Advanced Solid Tumors.
|
Phase 1/2 |
Recruiting |
AskGene Pharma, Inc. |
USA, China |
A Study Assessing KB707 for the Treatment of Advanced Solid Tumor Malignancies Affecting the Lungs
NCT06228326 · ClinicalTrials.gov ↗ · Lung Cancer, Non-small Cell, Lung Cancer Metastatic, Solid Tumor, Adult
|
Phase 1/2 |
Recruiting |
Krystal Biotech, Inc. |
USA |
Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)
NCT06353386 · ClinicalTrials.gov ↗ · Prostatic Neoplasms, Castration-Resistant
|
Phase 1/2 |
Recruiting |
Merck Sharp & Dohme LLC |
Ireland, UK, USA, China |
|
A Study of HRS-5041 Tablets Combined With Antitumor Therapy in Subjects With Advanced Prostate Cancer
|
Phase 1/2 |
Recruiting |
Jiangsu HengRui Medicine Co., Ltd. |
China |
A Phase I/II Study of LM-2417 in Subjects With Advanced Solid Tumours
NCT06682780 · ClinicalTrials.gov ↗ · Advanced Solid Tumor
|
Phase 1/2 |
Recruiting |
LaNova Medicines Limited |
China |
Safety, Tolerability, and Preliminary Efficacy of BH011 in Subjects With Non-Muscle-Invasive Bladder Cancer
NCT06732531 · ClinicalTrials.gov ↗ · Bladder Cancer, Non Muscle Invasive
|
Phase 1/2 |
Recruiting |
Zhuhai Beihai Biotech Co., Ltd |
China |
A Phase I/II Study of CS2009 in Participants With Advanced Solid Tumors
NCT06741644 · ClinicalTrials.gov ↗ · Advanced Solid Tumors
|
Phase 1/2 |
Recruiting |
CStone Pharmaceuticals |
USA, China |
A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)
NCT06863272 · ClinicalTrials.gov ↗ · Castration-Resistant Prostatic Cancer, Metastasis
|
Phase 1/2 |
Recruiting |
Merck Sharp & Dohme LLC |
Ireland, UK, USA |
AK129 Combination Therapy for Advanced Solid Tumors
NCT06943820 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer Stage IIIB/IV, Head and Neck Squamous Cell Carcinoma (HNSCC), Colorectal Adenocarcinoma
|
Phase 1/2 |
Recruiting |
Akeso |
China |
DZD6008 Combination Therapy in Patients With Locally Advanced or Metastatic NSCLC With EGFR Mutation (TIAN-SHAN7)
NCT07070440 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer
|
Phase 1/2 |
Recruiting |
Dizal Pharmaceuticals |
China |
Phase Ib/II Platform Study of Multiple Anti-Cancer Agents in Participants With Metastatic Prostate Cancer
NCT07590934 · ClinicalTrials.gov ↗ · Metastatic Prostate Cancer
|
Phase 1/2 |
Recruiting |
AstraZeneca |
UK, USA |
A Randomised Trial of Chemotherapy Plus Surgery for Recurrent Non-Small Cell Lung Cancer
NCT02889666 · ClinicalTrials.gov ↗ · Recurrent Non-small Cell Lung Cancer
|
Phase 1 |
Recruiting |
Shanghai Jiao Tong University School of Medicine |
China |
MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors
NCT05076760 · ClinicalTrials.gov ↗ · Solid Tumor, Advanced Cancer, Metastatic Cancer
|
Phase 1 |
Recruiting |
Memgen, Inc. |
USA |
Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer
NCT05142189 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer
|
Phase 1 |
Recruiting |
BioNTech SE |
UK, USA |
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
NCT05176483 · ClinicalTrials.gov ↗ · Renal Cell Carcinoma (RCC), Metastatic Castration-Resistant Prostate Cancer (mCRPC), Urothelial Carcinoma (UC)
|
Phase 1 |
Recruiting |
Exelixis |
UK, USA |
|
A Study of ASP3082 in Adults With Advanced Solid Tumors
|
Phase 1 |
Recruiting |
Astellas Pharma Inc |
USA, China |
A Study of ASP1002 in Adults for Treatment of Solid Tumors
NCT05719558 · ClinicalTrials.gov ↗ · Advanced Solid Tumors
|
Phase 1 |
Recruiting |
Astellas Pharma Global Development, Inc. |
USA |
A Study of Pasritamig (JNJ-78278343) in Combination With Other Agents for Metastatic Prostate Cancer
NCT05818683 · ClinicalTrials.gov ↗ · Metastatic Castration-resistant Prostate Neoplasms, Metastatic Hormone-sensitive Prostate Cancer
|
Phase 1 |
Recruiting |
Janssen Research & Development, LLC |
USA |
Study of HRS-5041 in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC)
NCT05942001 · ClinicalTrials.gov ↗ · Advanced Prostate Cancer
|
Phase 1 |
Recruiting |
Jiangsu HengRui Medicine Co., Ltd. |
China |
A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-130037 in Participants With Advanced Solid Tumors
NCT05954312 · ClinicalTrials.gov ↗ · Advanced Solid Tumors
|
Phase 1 |
Recruiting |
Vividion Therapeutics, Inc. |
USA |
FT825/ONO-8250, an Off-the-Shelf, HER2 CAR-T, With or Without Monoclonal Antibodies in Advanced Solid Tumors
NCT06241456 · ClinicalTrials.gov ↗ · Advanced Solid Tumor
|
Phase 1 |
Recruiting |
Fate Therapeutics |
USA |
A Study of KK2269 in Adult Participants With Solid Tumors
NCT06266299 · Advanced Solid Tumor, Metastatic Solid Tumor, Gastric Adenocarcinoma
|
Phase 1 |
Recruiting |
Kyowa Kirin Co., Ltd. |
USA |
Evaluation of JSKN016 Combination Therapy in Subjects With NSCLC
NCT06868732 · ClinicalTrials.gov ↗ · Advanced Non-small Cell Lung Cancer
|
Phase 1 |
Recruiting |
Jiangsu Alphamab Biopharmaceuticals Co., Ltd |
China |
A Phase Ib Clinical Study on the Safety and Efficacy of HC010 Combined With Chemotherapy in Lung Cancer
NCT07381829 · ClinicalTrials.gov ↗ · Advanced Solid Tumor Cancer
|
Phase 1 |
Recruiting |
HC Biopharma Inc. |
China |
Adjuvant Chemotherapy for High Malignant Prostate Cancer
NCT06864533 · ClinicalTrials.gov ↗ · Prostate Cancer, Radiation Therapy, Chemotherapy
|
Observational |
Recruiting |
Peking University First Hospital |
China |
The Management of Metastatic Neck Nodes in N2/3 Hypopharyngeal Squamous Cell Carcinoma
NCT05494190 · ClinicalTrials.gov ↗ · Hypopharyngeal Carcinoma
|
Not applicable |
Recruiting |
Eye & ENT Hospital of Fudan University |
China |
Effect of NST Whole-course Nutritional Management on Nutritional Status and Adverse Reactions in Esophageal Cancer
NCT05800054 · ClinicalTrials.gov ↗ · Esophageal Neoplasms, Adverse Drug Event
|
Not applicable |
Recruiting |
The First Affiliated Hospital with Nanjing Medical University |
China |
A Prospective, Open, Multicenter Single-arm Clinical Studie of Docetaxel, Carboplatin Combined With Inetetamab and Pyrotinib in the Treatment of Local-advanced HER2-positive Breast Cancer
NCT06234137 · ClinicalTrials.gov ↗ · Breast Neoplasm Female
|
Not applicable |
Recruiting |
Wang Ouchen |
China |
|
Efficacy and Safety of Lobaplatin and Carboplatin as Neoadjuvant Therapy in HER-2 Positive Breast Cancer
|
Phase 4 |
Not yet open |
Shandong Cancer Hospital and Institute |
China |
Phase 3 Trial of JMKX001899 Versus Docetaxel in Previously Treated Advanced or Metastatic KRAS G12C-Mutant NSCLC
NCT07242274 · ClinicalTrials.gov ↗ · NSCLC (Non-small Cell Lung Cancer)
|
Phase 3 |
Not yet open |
Jemincare |
China |
A Study to Evaluate CRB-701 Compared to Investigator's Choice Therapy in Previously Treated Oropharyngeal Squamous Cell Carcinoma
NCT07768189 · ClinicalTrials.gov ↗ · Oropharyngeal Carcinoma (OPC)
|
Phase 3 |
Not yet open |
Corbus Pharmaceuticals Inc. |
UK, USA |
A Study of ATG-022 Compared With Investigator's Choice of Treatment in Claudin 18.2-Positive Advanced Gastric or Gastroesophageal Junction Adenocarcinoma
NCT07795346 · ClinicalTrials.gov ↗ · Advanced Gastric or Gastroesophageal Junction Adenocarcinoma
|
Phase 3 |
Not yet open |
Antengene Biologics Limited |
China |
JSKN033 Versus Investigator's Choice of Chemotherapy in Recurrent or Metastatic Cervical Cancer
NCT07797153 · ClinicalTrials.gov ↗ · Recurrent or Metastatic Cervical Cancer
|
Phase 3 |
Not yet open |
Jiangsu Alphamab Biopharmaceuticals Co., Ltd |
China |
A Study of 7MW3711 Compared With Docetaxel in Advanced Squamous NSCLC After Prior Chemoimmunotherapy
NCT07831863 · ClinicalTrials.gov ↗ · Lung Squamous Cell Carcinoma
|
Phase 3 |
Not yet open |
Mabwell (Shanghai) Bioscience Co., Ltd. |
China |
Global, Multicenter Study of AMT-116 Versus Investigator's Choice in Participants With Advanced or Metastatic Non-squamous EGFR-Wildtype Non-Small Cell Lung Cancer (NSCLC) With Progression on or After Platinum-Based Chemotherapy and Anti-PD-1/PD-L1 Immunotherapy
NCT07718737 · ClinicalTrials.gov ↗ · NSCLC (Advanced Non-small Cell Lung Cancer)
|
Phase 2/3 |
Not yet open |
Multitude Therapeutics Inc. |
USA |
|
Mecapegfilgrastim Combined With Adebrelimab and Chemotherapy as Neoadjuvant Therapy in Resectable GC/GEJC
|
Phase 2 |
Not yet open |
The First Affiliated Hospital with Nanjing Medical University |
China |
Efficacy of Organoid-Based Chemotherapy Drug Precision Screening to Guide Treatment for Thyroid Cancer
NCT06713057 · ClinicalTrials.gov ↗ · Locally Advanced Thyroid Gland Carcinoma, Thyroid Cancer
|
Phase 2 |
Not yet open |
West China Hospital |
China |
Efficacy of TQB2102 Versus TCbHP in Neoadjuvant Therapy for HER2-positive Early Breast Cancer.
NCT07136974 · ClinicalTrials.gov ↗ · Breast Cancer, HER2 + Breast Cancer
|
Phase 2 |
Not yet open |
Henan Cancer Hospital |
China |
|
Evaluation of Neoadjuvant Therapy With Trastuzumab, Pertuzumab, Docetaxel, and QL1706 in Early or Locally Advanced HER2+ Breast Cancer
|
Phase 2 |
Not yet open |
Tianjin Medical University Cancer Institute and Hospital |
China |
CONVERT-HB1: Radical Prostatectomy After Systemic Therapy for High-volume Metastatic Hormone-sensitive Prostate Cancer
NCT07268794 · ClinicalTrials.gov ↗ · Metastatic Prostate Cancer, Prostate Cancer (Adenocarcinoma), Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
|
Phase 2 |
Not yet open |
Fudan University |
China |
A Clinical Study of SCTB41 Combined With Docetaxel in Patients With Previously Treated Locally Advanced or Metastatic Non-Small Cell Lung Cancer๏ผPhase II Study Ongoing๏ผ
NCT07609251 · ClinicalTrials.gov ↗ · NSCLC (Advanced Non-small Cell Lung Cancer)
|
Phase 2 |
Not yet open |
Sinocelltech Ltd. |
China |
A Single-Arm Study of QL1706 Combined With DOS as Neoadjuvant Therapy for Locally Advanced Gastric/GEJ Adenocarcinoma
NCT07828873 · ClinicalTrials.gov ↗ · Locally Advanced Gastric or Gastroesophageal Junction Adenocarcinoma
|
Phase 2 |
Not yet open |
The First Affiliated Hospital of Zhengzhou University |
China |
A Study of Docetaxel for Injection (Albumin-bound) and SG001 in Combination With Cisplatin and Simultaneous Radiotherapy for Locally Advanced Unresectable Esophageal Squamous Carcinoma.
NCT06136988 · ClinicalTrials.gov ↗ · Locally Advanced Unresectable Esophageal Squamous Carcinoma
|
Phase 1/2 |
Not yet open |
CSPC ZhongQi Pharmaceutical Technology Co., Ltd. |
China |
HSK41959 With Standard Therapy in Solid Tumors With MTAP Deletion
NCT07699757 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer, Pancreatic Ductal Adenocarcinoma (mPDAC), Advanced Solid Tumors
|
Phase 1 |
Not yet open |
Haisco Pharmaceutical Group Co., Ltd. |
China |
|
Adjuvant Albumin-bound Paclitaxel Versus Taxanes in Breast Cancer: a Real-world Study
|
Not applicable |
Not yet open |
Chinese Academy of Medical Sciences |
China |
BRIDGE Study: Neoadjuvant Finotonlimab, Cetuximab, and Docetaxel in Resectable Recurrent HNSCC After Immunotherapy Progression
NCT07618624 · ClinicalTrials.gov ↗ · Recurrent Head and Neck Squamous Cell Carcinoma, Head and Neck Cancer
|
Phase 2 |
By invitation |
Sun Yat-sen University |
China |
Assess Efficacy & Safety of Selumetinib in Combination With Docetaxel in Patients Receiving 2nd Line Treatment for v-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Positive NSCLC
NCT01933932 · Locally Advanced or Metastatic Non Small Cell Lung Cancer Stage IIIb - IV
|
Phase 3 |
Active, closed |
AstraZeneca |
UK, USA |
A Phase III Study for Patients With Metastatic Hormone-naรฏve Prostate Cancer
NCT01957436 · ClinicalTrials.gov ↗ · Metastatic Prostate Cancer
|
Phase 3 |
Active, closed |
UNICANCER |
Ireland |
Study to Assess Safety and Efficacy of Atezolizumab (MPDL3280A) Compared to Best Supportive Care Following Chemotherapy in Patients With Lung Cancer [IMpower010]
NCT02486718 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer
|
Phase 3 |
Active, closed |
Hoffmann-La Roche |
UK, USA, China |
|
A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations
|
Phase 3 |
Active, closed |
Janssen Research & Development, LLC |
UK, USA, China |
A Study of Neoadjuvant Chemotherapy Plus Nivolumab Versus Neoadjuvant Chemotherapy Plus Placebo, Followed by Surgical Removal and Adjuvant Treatment With Nivolumab or Placebo for Participants With Surgically Removable Early Stage Non-small Cell Lung Cancer
NCT04025879 · ClinicalTrials.gov ↗ · Carcinoma, Non-Small-Cell Lung
|
Phase 3 |
Active, closed |
Bristol-Myers Squibb |
Ireland, UK, USA, China |
|
Study Comparing EC-T Verses PCb in the Adjuvant Chemotherapy of Non-triple Negative Breast Cancer
|
Phase 3 |
Active, closed |
Fudan University |
China |
Study of Pembrolizumab (MK-3475) in Combination With Adjuvant Chemotherapy With or Without Radiotherapy in Participants With Newly Diagnosed Endometrial Cancer After Surgery With Curative Intent (MK-3475-B21 / KEYNOTE-B21 / ENGOT-en11 / GOG-3053)
NCT04634877 · ClinicalTrials.gov ↗ · Endometrial Neoplasms
|
Phase 3 |
Active, closed |
Merck Sharp & Dohme LLC |
UK, USA, China |
Study of DS-1062a Versus Docetaxel in Previously Treated Advanced or Metastatic Non-small Cell Lung Cancer With or Without Actionable Genomic Alterations (TROPION-LUNG01)
NCT04656652 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer
|
Phase 3 |
Active, closed |
Daiichi Sankyo |
UK, USA, China |
Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
NCT04685135 · ClinicalTrials.gov ↗ · Metastatic Non Small Cell Lung Cancer, Advanced Non Small Cell Lung Cancer
|
Phase 3 |
Active, closed |
Mirati Therapeutics Inc. |
Ireland, UK, USA, China |
Postoperative Adjuvant Chemotherapy in Early-stage Cervical Cancer That Not Meet Criteria of Adjuvant Therapeutic According to NCCN Guideline
NCT04723875 · ClinicalTrials.gov ↗ · Uterine Cervical Neoplasms, Cervical Cancer
|
Phase 3 |
Active, closed |
Huazhong University of Science and Technology |
China |
Study of Sacituzumab Govitecan (SG) Versus Docetaxel in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
NCT05089734 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer
|
Phase 3 |
Active, closed |
Gilead Sciences |
UK, USA |
Pembrolizumab/Placebo Plus Paclitaxel With or Without Bevacizumab for Platinum-resistant Recurrent Ovarian Cancer (MK-3475-B96/KEYNOTE-B96/ENGOT-ov65).
NCT05116189 · Ovarian Cancer, Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms
|
Phase 3 |
Active, closed |
Merck Sharp & Dohme LLC |
Ireland, UK, USA, China |
|
Study of JDQ443 in Comparison With Docetaxel in Participants With Locally Advanced or Metastatic KRAS G12C Mutant Non-small Cell Lung Cancer
|
Phase 3 |
Active, closed |
Novartis Pharmaceuticals |
USA, India, China |
Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma (MK-3475-C93/KEYNOTE-C93/GOG-3064/ENGOT-en15)
NCT05173987 · ClinicalTrials.gov ↗ · Endometrial Neoplasms
|
Phase 3 |
Active, closed |
Merck Sharp & Dohme LLC |
Ireland, UK, USA, China |
A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)
NCT05296798 · ClinicalTrials.gov ↗ · Locally Advanced or Metastatic Breast Cancer
|
Phase 3 |
Active, closed |
Hoffmann-La Roche |
UK, USA, India, China |
|
Study of Capivasertib + Docetaxel vs Placebo + Docetaxel as Treatment for Metastatic Castration Resistant Prostate Cancer (mCRPC)
|
Phase 3 |
Active, closed |
AstraZeneca |
UK, USA, India, China |
A Phase III Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Non Small Cell Lung Cancer (NSCLC) Whose Disease Progressed On or After Prior Anti PD (L)1 Therapy And Platinum Based Chemotherapy
NCT05450692 · Advanced or Metastatic Non-Small Cell Lung Cancer
|
Phase 3 |
Active, closed |
AstraZeneca |
Ireland, UK, USA, India, China |
ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors
NCT05671510 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer
|
Phase 3 |
Active, closed |
OncoC4, Inc. |
UK, USA, China |
A Study of SGN-B6A Versus Docetaxel in Previously Treated Non-small Cell Lung Cancer
NCT06012435 · ClinicalTrials.gov ↗ · Carcinoma, Non-Small-Cell Lung
|
Phase 3 |
Active, closed |
Seagen, a wholly owned subsidiary of Pfizer |
UK, USA, China |
Sacituzumab Tirumotecan (MK-2870) Versus Chemotherapy in Previously Treated Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With EGFR Mutations or Other Genomic Alterations (MK-2870-004)
NCT06074588 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer (NSCLC)
|
Phase 3 |
Active, closed |
Merck Sharp & Dohme LLC |
UK, USA, China |
A Study Comparing BL-B01D1 With Physician's Choice of Chemotherapy in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma(PANKU-NPC01)
NCT06118333 · ClinicalTrials.gov ↗ · Nasopharyngeal Carcinoma
|
Phase 3 |
Active, closed |
Sichuan Baili Pharmaceutical Co., Ltd. |
China |
AZD0901 Compared With Investigator's Choice of Therapy in Participants With Second- or Later-line Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Claudin18.2
NCT06346392 · ClinicalTrials.gov ↗ · Gastric Cancer, Gastroesophageal Junction Cancer
|
Phase 3 |
Active, closed |
AstraZeneca |
UK, USA, India, China |
A Study to Evaluate Sacituzumab Tirumotecan (MK-2870) in Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-2870-015)
NCT06356311 · ClinicalTrials.gov ↗ · Gastroesophageal Cancer
|
Phase 3 |
Active, closed |
Merck Sharp & Dohme LLC |
UK, USA, China |
A Study to Learn About the Investigational Medicine Called PF-06821497 (Mevrometostat) in Men With mCRPC Who Were Previously Treated With Abiraterone Acetate for Prostate Cancer (MEVPRO-1).
NCT06551324 · ClinicalTrials.gov ↗ · Metastatic Castrate Resistant Prostate Cancer (mCRPC)
|
Phase 3 |
Active, closed |
Pfizer |
UK, USA, China |
A Phase III Study of YL201 in Recurrent or Metastatic Nasopharyngeal Carcinoma (TAISHAN-301)
NCT06629597 · ClinicalTrials.gov ↗ · Nasopharyngeal Carcinoma
|
Phase 3 |
Active, closed |
MediLink Therapeutics (Suzhou) Co., Ltd. |
China |
Trial to Evaluate Acasunlimab and Pembrolizumab Combination Superiority Over Standard of Care Docetaxel in Non-Small Cell Lung Cancer (ABBIL1TY NSCLC-06)
NCT06635824 · PD-L1-positive, Locally Advanced (Unresectable Stage IIIB/C) or Metastatic NSCLC
|
Phase 3 |
Active, closed |
Genmab |
Ireland, UK, USA |
A Phase III Study of KN026 in Combination With HB1801 ยฑ Carboplatin as Neoadjuvant Treatment for Early or Locally Advanced HER2-Positive Breast Cancer
NCT06747338 · ClinicalTrials.gov ↗ · Early or Locally Advanced HER2-positive Breast Cancer
|
Phase 3 |
Active, closed |
Shanghai JMT-Bio Inc. |
China |
A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer
NCT06764485 · ClinicalTrials.gov ↗ · Metastatic Castration-resistant Prostate Cancer
|
Phase 3 |
Active, closed |
Celgene |
Ireland, UK, USA, China |
|
Study of HS-20093 Versus Gemcitabine in Combination With Docetaxel in Treatment of Osteosarcoma After Previous Second-line Treatment Failure
|
Phase 3 |
Active, closed |
Hansoh BioMedical R&D Company |
China |
A Trial of SHR-A1811 Compared to Other Antitumor Therapies as Neoadjuvant Treatments in Early-stage or Locally Advanced HER2-positive Breast Cancer
NCT07196774 · ClinicalTrials.gov ↗ · Early-stage or Locally Advanced HER2-positive Breast Cancer
|
Phase 3 |
Active, closed |
Jiangsu HengRui Medicine Co., Ltd. |
China |
TA(E)C-GP Versus A(E)C-T for the High Risk TNBC Patients and Validation of the mRNA-lncRNA Signature
NCT02641847 · ClinicalTrials.gov ↗ · Triple Negative Breast Cancer, Breast Cancer
|
Phase 2/3 |
Active, closed |
Fudan University |
China |
|
A Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC)
|
Phase 2/3 |
Active, closed |
Hoffmann-La Roche |
USA, China |
Compare Neoadjuvant DOS Combined With Toripalimab Versus SOX Combined With Toripalimab in Locally Advanced Gastric Adenocarcinoma
NCT03691454 · ClinicalTrials.gov ↗ · Gastric Adenocarcinoma
|
Phase 2/3 |
Active, closed |
Peking University |
China |
|
Efficacy Comparison of Cobolimab + Dostarlimab + Docetaxel to Dostarlimab + Docetaxel to Docetaxel Alone in Participants With Advanced Non-small Cell Lung Cancer Who Have Progressed on Prior Anti-PD-(L)1 Therapy and Chemotherapy
|
Phase 2/3 |
Active, closed |
GlaxoSmithKline |
UK, USA |
A Study of ARX788 Combined With Pyrotinib Maleate Versus TCBHP (Trastuzumab Plus Pertuzumab With Docetaxel and Carboplatin) as Neoadjuvant Treatment in HER2-positive Breast Cancer Patients
NCT05426486 · ClinicalTrials.gov ↗ · HER2-positive Breast Cancer
|
Phase 2/3 |
Active, closed |
Caigang Liu |
China |
A Safety Extension Study of Trastuzumab Emtansine in Participants Previously Treated With Trastuzumab Emtansine Alone or in Combination With Other Anti-Cancer Therapy in One of the Parent Studies
NCT00781612 · ClinicalTrials.gov ↗ · Neoplasm Metastasis
|
Phase 2 |
Active, closed |
Genentech, Inc. |
UK, USA, China |
QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors
NCT03228667 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Urothelial Carcinoma
|
Phase 2 |
Active, closed |
ImmunityBio, Inc. |
USA |
Therapeutic Effect of Cytoreductive Radical Prostatectomy in Men With Newly Diagnosed Metastatic Prostate Cancer
NCT03456843 · ClinicalTrials.gov ↗ · Stage IV Prostate Adenocarcinoma AJCC v7
|
Phase 2 |
Active, closed |
Yale University |
China |
A Study of Zolbetuximab (IMAB362) in Adults With Gastric Cancer
NCT03505320 · ClinicalTrials.gov ↗ · Pharmacokinetics of Zolbetuximab, Gastric Cancer, Gastro-esophageal Junction (GEJ) Cancer
|
Phase 2 |
Active, closed |
Astellas Pharma Global Development, Inc. |
USA |
|
ACHP-THP vs EC-THP as Neoadjuvant Therapy for HER2-positive EBC
|
Phase 2 |
Active, closed |
Sun Yat-sen University |
China |
|
A Trial of AK112 (PD1/VEGF Bispecific) in Combination With Chemotherapy in Patients With NSCLC
|
Phase 2 |
Active, closed |
Akeso |
China |
Pyrotinib Plus Neoadjuvant Chemotherapy in HR+/HER2-, HER4-High Breast Cancer
NCT04872985 · ClinicalTrials.gov ↗ · Breast Cancer, Hormone-receptor Positive Breast Cancer
|
Phase 2 |
Active, closed |
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University |
China |
SI-B001 Combined With Chemotherapy in the Treatment of EGFR/ALK WT Recurrent or Metastatic NSCLC.
NCT05020457 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer
|
Phase 2 |
Active, closed |
Sichuan Baili Pharmaceutical Co., Ltd. |
China |
A Clinical Study of SI-B001 in Combination With Paclitaxel/Docetaxel in the Treatment of Recurrent and Metastatic HNSCC
NCT05054439 · ClinicalTrials.gov ↗ · Head and Neck Squamous Cell Carcinoma
|
Phase 2 |
Active, closed |
Sichuan Baili Pharmaceutical Co., Ltd. |
China |
Study of Novel Treatment Combinations in Patients With Lung Cancer
NCT05633667 · ClinicalTrials.gov ↗ · Lung Cancer, Advanced or Metastatic Non-Small-Cell Lung Cancer, Resectable Non-Small-Cell Lung Cancer
|
Phase 2 |
Active, closed |
Gilead Sciences |
UK, USA |
Study With Various Immunotherapy Treatments in Participants With Lung Cancer
NCT05676931 · ClinicalTrials.gov ↗ · Advanced Non-Small Cell Lung Cancer
|
Phase 2 |
Active, closed |
Gilead Sciences |
UK, USA |
A Study of BL-M07D1, BL-M07D1+Pertuzumab and BL-M07D1+Pertuzumab+Docetaxel in Patients With Unresectable Locally Advanced or Metastatic HER2-positive Breast Cancer
NCT06445400 · ClinicalTrials.gov ↗ · HER2-positive Breast Cancer
|
Phase 2 |
Active, closed |
Sichuan Baili Pharmaceutical Co., Ltd. |
China |
Neoadjuvant Toripalimab Plus Docetaxel and Carboplatin in Patients With Localized TNBC (NeoTOP)
NCT06618014 · ClinicalTrials.gov ↗ · Breast Cancer, Triple Negative Breast Cancer
|
Phase 2 |
Active, closed |
Sun Yat-sen University |
China |
Study to Evaluate Adverse Events and Change in Disease Activity When Intravenously (IV) Infused Livmoniplimab is Used in Combination With IV Infused Budigalimab in Adult Participants With Urothelial Carcinoma (UC)
NCT06632951 · ClinicalTrials.gov ↗ · Urothelial Carcinoma
|
Phase 2 |
Active, closed |
AbbVie |
USA |
A Randomized Controlled Study of Serplulimab Combined With Chemotherapy for Locally Advanced Gastric Adenocarcinoma
NCT07257575 · ClinicalTrials.gov ↗ · Gastric Cancer Stage III
|
Phase 2 |
Active, closed |
Guangdong Provincial People's Hospital |
China |
Iparomlimab and Tuvonralimab Injection (QL1706) Combined With DOS as Neoadjuvant Therapy for Locally Advanced Adenocarcinoma of the Stomach and Gastroesophageal Junction
NCT07776639 · ClinicalTrials.gov ↗ · Gastroesophageal Junction Adenocarcinoma, Gastric Adenocarcinoma
|
Phase 2 |
Active, closed |
Yongxu Jia |
China |
Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC
NCT04140526 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer, Advanced Solid Tumor, Metastatic Melanoma
|
Phase 1/2 |
Active, closed |
OncoC4, Inc. |
USA |
A Study of Anvumetostat in Participants With Advanced MTAP-null Solid Tumors (MTAPESTRY 101)
NCT05094336 · ClinicalTrials.gov ↗ · Advanced MTAP-null Solid Tumors
|
Phase 1/2 |
Active, closed |
Amgen |
UK, USA, China |
AK112 and AK104 With or Without Chemotherapy in Advanced Non-small Cell Lung Cancer
NCT05904379 · ClinicalTrials.gov ↗ · Advanced Non-small-cell Lung Cancer
|
Phase 1/2 |
Active, closed |
Akeso |
China |
|
A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)
|
Phase 1 |
Active, closed |
Tesaro, Inc. |
USA |
Study of Intravenous (IV) ABBV-637 Alone or in Combination With IV Docetaxel/Osimertinib to Assess Adverse Events and Change in Disease Activity in Adult Participants With Relapsed/Refractory (R/R) Solid Tumors
NCT04721015 · ClinicalTrials.gov ↗ · Advanced Solid Tumors Cancer, Non Small Cell Lung Cancer (NSCLC)
|
Phase 1 |
Active, closed |
AbbVie |
USA |
|
A Study of AB801 Monotherapy and Combination Therapy in Participants With Advanced Malignancies
|
Phase 1 |
Active, closed |
Arcus Biosciences, Inc. |
USA |
A Study to Learn How Men With Advanced Prostate Cancer Respond to Treatment With Darolutamide and Hormone Therapy, With or Without Chemotherapy, in Real-world Medical Practice
NCT07344779 · ClinicalTrials.gov ↗ · Metastatic Hormone-Sensitive Prostate Cancer
|
Observational |
Active, closed |
Bayer |
UK |