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Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide The €100K Reality Check: Why a Six-Figure Pharma Salary in Ireland Feels Different Than in Switzerland or Germany Ireland's €93.8 Billion Non-EU Pharma Export Engine: Trade Data, Destination Markets, and Economic Impact Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide The €100K Reality Check: Why a Six-Figure Pharma Salary in Ireland Feels Different Than in Switzerland or Germany Ireland's €93.8 Billion Non-EU Pharma Export Engine: Trade Data, Destination Markets, and Economic Impact
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Trackers› Clinical trials› Ireland
Clinical trial register · Ireland

Clinical Trials in Ireland

Every study on the ClinicalTrials.gov registry that lists a site in Ireland and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 597 matching records held by the registry are in this view. Synced 04 Oct 2026, 03:15 UTC
597
Studies in scope
all four open statuses
304
Recruiting now
open to new participants
168
Lead sponsors
across recruiting studies
37
Irish site locations
across all listed studies
Phase mix of the 304 recruiting studies
Phase 3 92 Not applicable 75 Observational 72 Phase 2 26 Phase 1/2 21 Other 18
Narrow the register
Matches title, registry number, sponsor, intervention and condition.
Recruitment status
Phase
Lead sponsor
Merck Sharp & Dohme LLC 35 Royal College of Surgeons, Ireland 29 University College Dublin 21 AbbVie 20 University College Cork 18
Site location
Dublin 479 Cork 168 Galway 123 Limerick 56 Waterford 52
All 37 locations
Target enrolment
to

Trials in this register

597 of 597 studies
Download
Status
Study
Lead sponsor
Phase
Enrol
Irish sites
Start
Not yet open
An Open-Label Study to Evaluate the Long-Term Safety and Efficacy of ALXN2220 in Adults With Transthyretin Amyloid Cardiomyopathy
NCT07789483 Transthyretin Amyloid Cardiomyopathy (ATTR-CM)
DrugCliramitug
Alexion Pharmaceuticals, Inc.
Phase 3
1,180
Dublin
2027-11-23
Not yet open
Long-term Extension Study to Evaluate Safety and Tolerability of Admilparant in Participants With Pulmonary Fibrosis
NCT07441408 Pulmonary Fibrosis
DrugAdmilparant
Bristol-Myers Squibb
Phase 3
2,380
Tallaght, Drogheda, Dublin
2026-12-16
Not yet open
Tracheostomy Practice in Adult Intensive Care Units
NCT07769021 Tracheostomy Patients, Tracheostomy Decannulation, Intensive Care (ICU)
Royal College of Surgeons, Ireland
Observational
2,500
Dublin, Galway
2026-11-02
Not yet open
Patient-Initiated Follow-Up for Women After Early Breast Cancer Treatment (LYSA2PIFU)
NCT07840534 Breast Cancer, Breast Cancer Survivorship, Cancer Survivorship, Endocrine Therapy
University College Cork
Not applicable
30
Cork
2026-10-01
Not yet open
Dissecting the Roles of High-quality Diets and Ultra Processed Foods on Cardiometabolic Health
NCT06749327 Cardiometabolic Risk Factors
Queen's University, Belfast
Not applicable
330
Dublin
2026-10-01
Not yet open
OPTIMISE Lung SABR
NCT07777614 Non Small Cell Lung Cancer
Cancer Trials Ireland
Phase 2
208
Dublin
2026-10
Recruiting
A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib
NCT07623161 Myelofibrosis, Anemia
DrugElritercept
Takeda
Phase 3
324
Cork, Dublin, Galway
2026-09-10
Recruiting
Dual Antiplatelet Therapy Strategies After Acute Myocardial Infarction Undergoing PCI: Prasugrel vs Ticagrelor & 12 Months vs 1-3 Months
NCT07507500 Myocardial Infarction (MI)
DrugsPrasugrel·Ticagrelor
Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Phase 4
8,100
Dublin
2026-09-02
Not yet open
Natural History Study of Advanced RCD
NCT07854899 Rod Cone Dystrophy
SparingVision
Not applicable
100
Dublin
2026-09
Not yet open
The OAT Trail: The Obesity Anti-Coagulation Thromboprophylaxis Trial.
NCT07559643 Bariatric Surgery, Anti-Xa Activity, VTE (Venous Thromboembolism), Obesity & Overweight
DrugsTinzaparin·Enoxaparin
University College Dublin
Not applicable
180
Dublin
2026-08-01
Recruiting
A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)
NCT07492680 Solid Tumors
DrugsNavlimetostat·Pumitamig·Temozolomide·Cetuximab
Bristol-Myers Squibb
Phase 2
260
Cork, Dublin
2026-07-27
Recruiting
Evaluation of the FARAFLEX Mapping and Pulsed Field Ablation System in Subjects With Atrial Fibrillation
NCT07575269 Paroxysmal Atrial Fibrillation (PAF), Persistent Atrial Fibrillation
Boston Scientific Corporation
Not applicable
571
Dublin
2026-07-07
Recruiting
Optimising Adjuvant Chemotherapy Prescription in Young Patients With Hormone-dependent Breast Cancer Using Genomic Tests
NCT07106632 Early Breast Cancer, Premenopausal Breast Cancer, HR+/HER2- Breast Cancer
UNICANCER
Phase 3
3,380
Cork, Dublin, Limerick, Tullamore, Waterford
2026-06-26
Active, closed
Safety and User Experience of BP-CBB
NCT07628608 Safety and Tolerability in Healthy Volunteers
Bactolife A/S
Not applicable
60
Cork
2026-06-16
By invitation
Evaluation of Commercially Available Heel Pads for the Prevention of Pressure Ulcers: An Observational Study of Incidence and Usability in Adult Surgical Patients.
NCT07852897 Pressure Injury Prevention
Trulife
Observational
35
Dublin
2026-06-09
Recruiting
Phase 2 Study of Disease Risk Mutation-Guided Finite Acalabrutinib+Venetoclax for Relapsed CLL Post-1L Finite cBTKi+BCL2i ± Obinutuzumab
NCT07024706 Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL)
DrugsVenclyxto·Acalabrutinib·Venclexta·Venetoclax
AstraZeneca
Phase 2
80
Dublin
2026-06-04
Recruiting
The PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity
NCT06494878 Venous Thromboembolism, Postpartum Period, Aspirin, Low Molecular Weight Heparin
DrugsDalteparin·Tinzaparin·Low molecular weight heparin·Enoxaparin
University of Calgary
Phase 3
8,805
Dublin
2026-06-04
Not yet open
A Study of Barrett's Esophagus Patients: Optimization of a Risk Model to Better Predict the Development of Cancer Recurrence and the Effect of Risk Profile Disclosure on Patient Quality of Life and Fear of Cancer
NCT07455422 Barrett Esophagus, Barrett Esophagus Adenocarcinoma, Adenocarcinoma - GEJ, Gastroenterology
University Hospital, Antwerp
Not applicable
266
Dublin
2026-06-01
Recruiting
Eating Behaviour Before, During, and After Obesity Medication
NCT07636395 Obesity Type 2 Diabetes Mellitus, Obesity & Overweight
University College Dublin
Observational
30
Dublin
2026-05-25
Recruiting
A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions
NCT07422480 Myelodysplastic Syndrome, Anemia
DrugsElritercept·Epoetin Alfa
Takeda
Phase 3
300
Cork, Dublin, Galway
2026-05-21
Recruiting
A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer
NCT07287098 Breast Neoplasms
DrugsImlunestrant·Goserelin·Tamoxifen
Eli Lilly and Company
Phase 2
600
Dublin, Galway
2026-05-13
Recruiting
Barefoot Walking VS Standardised Conservative Care for Plantar Fasciopathy
NCT07600229 Plantar Fasciopathy, Plantar Fasciitis, Plantar Fasciitis, Chronic, Heel Pain
Elisabetta Brigo
Not applicable
74
Carlow
2026-05-07
Recruiting
A Non-inferiority Pharmacokinetic and Safety/Tolerability Study of Two Different Doses of Weekly SC Alpha1-PI 15% Compared With Corresponding Standard IV Alpha1-PI in Participants With Alpha1-Antitrypsin Deficiency (AATD)
NCT07555483 Alpha 1 Antitrypsin Deficiency
Grifols Therapeutics LLC
Phase 3
40
Dublin
2026-05-05
Recruiting
Glycolytic Phenotype (vLapeak) and Magnitude of Skeletal Muscle Hypertrophy After Resistance Training
NCT07721766 Healthy Volunteers, Muscle Hypertrophy, Glycolysis, Moderately Trainend
Technical University of Munich
Not applicable
120
Limerick
2026-05-04
Not yet open
A Single-Arm Interventional Trial of Pepper- Robot Delivered Cancer Education for Adults With Intellectual Disability
NCT07477938 Cancer Awareness and Prevention Education, Breast Cancer Awareness, Intellectual Disabilities (F70-F79)
National University of Ireland, Galway, Ireland
Not applicable
25
Galway
2026-05-01
Recruiting
The Development of the Walsh Asthma Self-management Programme and Feasibility of Implementation in Adults With Asthma in Primary Care
NCT07609134 Asthma, Self-management, Asthma Control
Royal College of Surgeons, Ireland
Not applicable
40
Dublin
2026-05
Recruiting
NeoSHARK: Anatomical Versus Round Facemasks for Breathing Support in Preterm and Term Newborn Infants
NCT07524517 Neonatal Intensive Care
University College Dublin
Not applicable
50
Dublin
2026-05
Recruiting
INSPIRE: INnovative SABR for Prostate Cancer All IREland
NCT07552168 Prostate Adenocarcinoma
Cancer Trials Ireland
Phase 2
136
Dublin, Cork, Waterford
2026-04-23
Recruiting
Frailty in Older Adults With Prostate Cancer: a Prospective Cohort Study
NCT07605936 Frailty at Older Adults, Prostate Cancer
University of Limerick
Observational
80
Limerick
2026-04-23
Recruiting
A Study of Azenosertib (ZN-c3) Versus Investigator's Choice Chemotherapy in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers Positive for Cyclin E1 Protein Expression
NCT07546500 Ovarian Cancer
DrugAzenosertib
K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc
Phase 3
420
Cork, Dublin
2026-04-17
Recruiting
Generating Intervals of Reference FFor Early Life Brain Biomarkers.
NCT07585149 Reference Intervals, Biomarker in Early Diagnosis, Neonatal
University College Cork
Observational
150
Cork
2026-04-13
By invitation
Telemedicine Rash Evaluation and Assessment of Toxicity in Skin in Acute Oncology and Haematology Care: A Pilot Study
NCT07476807 Rash, Systemic Treatments, Tele-assessment
Sligo General Hospital
Not applicable
25
Sligo
2026-04-01
Not yet open
An Intervention Study in Healthy Infants Aged 0-6 Months With Probiotics Lacticaseibacillus Rhamnosus LRa05 (LRa05) and Bifidobacterium Animalis Subsp. Lactis BLa80 (BLa80) vs. Placebo, for Promoting Gut Microbiome Development.
NCT07505329 Less Than 3 Months Old, Healthy Infants
University College Cork
Not applicable
300
Cork
2026-04
Not yet open
Self-Expanding Hydra Transcatheter Heart Valve (THV) Series Versus Balloon-Expandable Devices for Valve-In-Valve Transcatheter Aortic Valve Implantation (TAVI) for Patients With Failed Surgical Aortic Bioprosthesis.
NCT07524595 AORTIC VALVE DISEASES, Valve-in-valve Procedures, Surgical Valve Replacement, Valve Disease, Aortic
National University of Ireland, Galway, Ireland
Not applicable
111
Galway
2026-04
Recruiting
Comprehensive LEFt Atrial Appendage Occlusion With Rhythm Restoration
NCT07523620 Atrial Fibrillation (AF), Paroxysmal AF, Persistent Atrial Fibrillation
Abbott Medical Devices
Not applicable
240
Dublin
2026-03-31
Recruiting
InRAD Observational Study
NCT07213700 Alzheimer's Disease(AD), Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), Non-Alzheimer Degenerative Dementia
Stichting International Registry for Alzheimer's Disease and other Dementias Foundation
Observational
50,000
Dublin
2026-03-30
Recruiting
A Study to Evaluate the Safety, Tolerability, and Efficacy of Pumitamig Alone or in Combination With Other Agents in Participants With Advanced Renal Cell Carcinoma (RCC) (ROSETTA RCC-208)
NCT07293351 Advanced Renal Cell Carcinoma (RCC)
DrugsCasdatifan·Pumitamig·Cabozantinib·Yervoy
Bristol-Myers Squibb
Phase 1/2
474
Dublin
2026-03-26
Recruiting
CP: Intestinal Permeability
NCT07586930 Intestinal Permability
Rousselot BVBA
Not applicable
92
Cork
2026-03-25
Recruiting
The Effect of a Synbiotic on Intestinal Barrier Function and Microbiota Modulation in Middle-aged to Elderly Individuals With Excessive Body Weight
NCT07453823 Gastrointestinal Microbiome (Focus), Gastrointestinal Symptoms
Chr Hansen - part of Novonesis
Not applicable
90
Cork
2026-03-18
Recruiting
A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)
NCT07361497 Non-small Cell Lung Cancer (NSCLC)
DrugsPumitamig·Durvalumab
Bristol-Myers Squibb
Phase 3
850
Cork, Dublin
2026-03-16
Recruiting
A Study of Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
NCT07218341 Chronic Lymphocytic Leukemia, Lymphoma, Small Lymphocytic
DrugsIdelalisib·Pirtobrutinib
Eli Lilly and Company
Phase 4
150
Dublin
2026-03-09
Not yet open
The Effectiveness of the Twin Block and Carriere Motion Appliances in Post-pubertal Patients and an Evaluation of the Impact of Class II Malocclusion and Its Correction on Oral Health-related Quality of Life
NCT07292636 CLASS II DIVISION 1 MALOCCLUSION, Class II Malocclusion, Growth, Overjet
Aslam Alkadhimi
Not applicable
88
Dublin
2026-03
Recruiting
Optimal Mammography View Sequencing in Women With a History of Breast Cancer Undergoing Surveillance Mammography
NCT07443579 Breast Cancer, Breast Cancer Recurrence, Post Treatment Surveillance
Royal College of Surgeons, Ireland
Not applicable
400
Beaumont
2026-02-24
Not yet open
Exploring the Feasibility of Using Virtual Reality as an Educational Tool in Chronic Pain Rehabilitation
NCT07434804 Pain, Chronic Pain, Chronic Pain (Back / Neck), Adults
University College Dublin
Not applicable
50
Dublin
2026-02-20
Recruiting
CR-001 in Adult Participants With Locally Advanced or Metastatic Solid Tumors
NCT07335497 Locally Advanced / Metastatic Solid Tumors
Crescent Biopharma, Inc.
Phase 1/2
290
Dublin
2026-02-17
Recruiting
A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)
NCT07318558 Ovarian Neoplasms, Ovarian Cancer
DrugsMvasi·Sacituzumab tirumotecan·Avastin·Bevacizumab
Merck Sharp & Dohme LLC
Phase 3
900
Cork, Dublin
2026-02-16
Recruiting
TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy
NCT07223203 Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy, hATTR-PN
DrugsNucresiran·Vutrisiran
Alnylam Pharmaceuticals
Phase 3
125
Dublin
2026-02-03
Recruiting
Chemokeyp: A Feasibility Study for Realtime Safety Data-Capture for Potential Serious Adverse Drug Events
NCT07592234 Serious Adverse Events, Patient Safety, Pharmacovigilance, Oncology
St Vincent's University Hospital, Ireland
Observational
100
Dublin
2026-02-01
Recruiting
Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS
NCT07322003 Amyotrophic Lateral Sclerosis
DrugPridopidine
Prilenia
Phase 3
500
Dublin
2026-02-01
Not yet open
Implementation of an Advanced Telerehabilitation Solution for People With Multiple Sclerosis
NCT07310914 Multiple Sclerosis
Danish Multiple Sclerosis Hospitals
Phase 2
94
Dublin
2026-02-01
Not yet open
Strategic Timing of Resistance Training to Guard Against Antipsychotic-Induced Metabolic Syndrome
NCT07386483 Psychosis
University College Dublin
Not applicable
40
Dublin
2026-02-01
Not yet open
Improving ADHD Symptoms and Quality of Life Through Diet
NCT07376746 ADHD
University College Cork
Not applicable
200
Cork
2026-02
Recruiting
Bimodal Electrical-Sound Stimulation and Auditory Training for Chronic Tonal Tinnitus
NCT07393880 Tinnitus, Subjective, Tinnitus, Chronic Tinnitus
University of Dublin, Trinity College
Not applicable
100
Dublin
2026-01-30
Recruiting
Speech-based Assessment of Relapse Risk in People With Psychosis
NCT07397975 Psychotic Disorder
Philipp Homan
Observational
360
Greystones
2026-01-29
Recruiting
Arthrosamid vs. Steroid for the Management of Knee Osteoarthritis
NCT07489521 Osteo Arthritis Knee, Osteoarthritis, Intraarticular Injection
Cappagh National Orthopaedic Hospital
Phase 4
200
Dublin
2026-01-29
Recruiting
Drug-drug Interaction Study With AZD5335 and Itraconazole in Participants With Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
NCT07402915 Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal
DrugsTorvutatug samrotecan·Itraconazole
AstraZeneca
Phase 1
32
Dublin
2026-01-26
Recruiting
Efficacy and Safety of Vamifeport in Adult Participants With Homeostatic Iron Regulator Gene (HFE)-Related Hereditary Hemochromatosis
NCT07332091 Homeostatic Iron Regulator Gene-related Hereditary Hemochromatosis
CSL Behring
Phase 2
84
Cork, Dublin
2026-01-22
Recruiting
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)
NCT07216703 Cervical Cancer
DrugsMvasi·Sacituzumab tirumotecan·Paraplatin·Avastin
Merck Sharp & Dohme LLC
Phase 3
1,023
Cork, Dublin
2026-01-19
Active, closed
Probiotic in Fruit Snack
NCT07679490 Colonization, Asymptomatic, Probiotic Intervention, Gut Microbiota Diversity and Composition, Gut-brain Axis
University College Dublin
Not applicable
25
Dublin
2026-01-18
Not yet open
Assessing Sensor-Guided Compression Therapy for Venous Leg Ulcers Healing Outcomes
NCT07268482 Venous Leg Ulcer (VLU)
Feeltect Limited
Not applicable
40
Galway
2026-01-15
Recruiting
A Smart Phone Application to Improve Adoption of the 2024 Kidney Disease Improving Global Outcomes (KDIGO) Chronic Kidney Disease (CKD) Guidelines
NCT07561957 Chronic Kidney Disease, Proteinuria, Blood Pressure Control, Congenital Anomalies of the Kidneys and Urinary Tract
St. James's Hospital, Ireland
Not applicable
80
Dublin
2026-01-14
Recruiting
A Clinical Study to Assess the Efficacy of Adjuvant Immunotherapy With Cemiplimab in Patients With Surgically Removed Non-small Cell Lung Cancer Who Have Not Received Prior Chemotherapy
NCT06931717 Non-Small Cell Lung Cancer
DrugCemiplimab
ETOP IBCSG Partners Foundation
Phase 3
390
Cork, Dublin
2026-01-12
Recruiting
Profiling Patients With Rotator Cuff Related Shoulder Pain: What Factors Influence Outcomes With Non-operative Care in a Secondary Care Specialist Shoulder Clinic?
NCT07360847 Rotator Cuff Related Shoulder Pain, RCRSP
University of Limerick
Observational
150
Limerick
2026-01-05
Recruiting
Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery
NCT07140172 Breast Cancer
University Hospital, Basel, Switzerland
Not applicable
1,060
Cork, Dublin, Galway
2026-01-01
Recruiting
The ACHILLS Trial; Application of Cerament in Heel Infection for Lower Limb Salvage
NCT07057817 Osteomyelitis, Diabetes, Calcanectomy
Royal College of Surgeons, Ireland
Not applicable
30
Galway
2026-01-01
Recruiting
AZD5335 vs. Mirvetuximab Soravtansine in FRα-high and AZD5335 vs. Chemotherapy in FRα-low Platinum-resistant Ovarian Cancer
NCT07218809 Epithelial Ovarian Cancer
DrugsTorvutatug samrotecan·MIRV·Mirvetuximab Soravtansine·Pegylated liposomal doxorubicin
AstraZeneca
Phase 3
1,100
Cork, Dublin, Waterford
2025-12-29
Recruiting
A Study to Learn How Safe and How Well Linvoseltamab Works Compared to Standard Treatment in Adult Patients With Multiple Myeloma Who Are Not Eligible for Transplant
NCT06932562 Multiple Myeloma
DrugsLinvoseltamab·Daratumumab·Lenalidomide·Dexamethasone
European Myeloma Network B.V.
Phase 3
1,000
Cork, Dublin, Limerick
2025-12-23
Recruiting
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
NCT07174336 Breast Neoplasms, Neoplasm Metastasis
DrugsTersolisib·Exemestane·Anastrozole·Ribociclib
Eli Lilly and Company
Phase 3
800
Cork, Dublin, Galway
2025-12-22
Recruiting
Pre-Operative Nurse-Led Education With Direct Physiotherapy Referral to Reduce Post-Prostatectomy Incontinence
NCT07426861 Prostate Cancer, Urinary Incontinence, Postoperative Complications, Radical Prostatectomy
Royal College of Surgeons, Ireland
Not applicable
80
Beaumont
2025-12-20
Recruiting
The PHARO Trial: The Incidence of Para-conduit Hernia With Closure of Hiatus Versus the Standard Approach in Robotic Oesophagectomy - A Randomised Controlled Pilot Trial
NCT07426835 Oesphageal Cancer, Para-conduit Hernia
Royal College of Surgeons, Ireland
Not applicable
40
Dublin
2025-12-19
Recruiting
OT SMILE: Occupational Therapy Group Intervention for Primary Brain Tumour Patients
NCT07426848 Primary Brain Tumour, Glioblastoma, Brain Neoplasms
Royal College of Surgeons, Ireland
Not applicable
96
Dublin
2025-12-18
Recruiting
Margin Optimisation Using Z-axis Assessment With Real-time Tomosynthesis (MOZART Study).
NCT07426809 Breast Cancer
Royal College of Surgeons, Ireland
Not applicable
314
Beaumont
2025-12-18
Recruiting
A Study of OTP-01, a Dual Paratopic PD-1/VEGFR2 Antibody, in Patients With Advanced Solid Tumors
NCT07266428 Advanced Solid Tumors
Ottimo Pharma Limited
Phase 1/2
170
Dublin
2025-12-17
Recruiting
An Early Phase Trial of RPTR-1-201 in Advanced Solid Tumors
NCT07293754 Advanced Malignant Solid Tumor
Repertoire Immune Medicines
Phase 1/2
150
Dublin
2025-12-12
Recruiting
The Impact of Concurrent Training on Women Experiencing Symptoms of Menopause
NCT07417228 Menopause Symptoms
University College Dublin
Not applicable
90
Dublin
2025-12-12
Recruiting
Evaluating the De-Escalation of Surveillance for Patients Who Have Undergone Curative Treatment for Breast Cancer
NCT07572370 Breast Cancer
Royal College of Surgeons, Ireland
Observational
560
Dublin
2025-12-11
Recruiting
BaLloon-based PFA Ablation poST Approval Outcomes for PAF and PersAF
NCT07181590 Paroxysmal AF, Atrial Arrhythmia, Atrial Fibrillation, Persistent Atrial Fibrillation
Abbott Medical Devices
Not applicable
300
Dublin
2025-12-11
Recruiting
The Effect of Urolithin A (Mitopure®) Supplementation on Muscle Strength in Healthy Middle-Aged Adults
NCT07231783 Healthy Aging, Muscle Function
Amazentis SA
Not applicable
120
Cork
2025-12-10
Recruiting
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
NCT06793397 Major Depressive Disorder (MDD), Depression in Adults, Depression - Major Depressive Disorder, Depression Disorders
DrugCYB003
Cybin IRL Limited
Phase 3
330
Dublin, Galway
2025-12-10
Recruiting
Assessment and Prediction of Cardiovascular Health and Disease Risk Using Wearable Biometrics.
NCT07401550 Cardiovascular Diseases (CVD), Cardiovascular Disease Prevention, Cardiovascular Disease Risk Factor, Coronary Artery Disease (CAD)
University College Dublin
Observational
100
Dublin
2025-12-09
Recruiting
Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
NCT07214779 Ovarian Cancer
DrugINCB123667
Incyte Corporation
Phase 3
466
Dublin, Galway, Waterford
2025-12-09
Recruiting
A Study of Valemetostat (DS-3201b) in Combination With Darolutamide in Metastatic Castration Resistant Prostate Cancer (mCRPC)
NCT07244341 Metastatic Castration-resistant Prostate Cancer
DrugsValemetostat·Darolutamide
Daiichi Sankyo
Phase 1
60
Dublin
2025-12-03
Recruiting
Evaluation of Wellbeing and Patient Reported Outcomes After Open vs Robotic Mastectomy With DIEP Reconstruction
NCT07230535 Breast Cancer, Breast Neoplasms, Breast Reconstruction, DIEP Flap Breast Reconstruction, Robotic Surgery
Beaumont Hospital
Not applicable
250
Beaumont
2025-12-01
Recruiting
A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)
NCT07227402 Renal Cell Carcinoma
DrugsZanzalintinib·Belzutifan·Cabozantinib
Merck Sharp & Dohme LLC
Phase 3
904
Cork, Dublin
2025-11-26
Recruiting
Evaluating the Efficacy of the Psoas Sheath Block for Post Operative Analgesia Following Hip Arthroplasty
NCT07453498 Total Hip Arthroplasty (THA)
University College Hospital Galway
Not applicable
130
Galway
2025-11-18
Recruiting
Precision Oncology Clinical Diagnostic Study In Primary and Metastatic Breast Cancer (PRISM)
NCT07425002 Breast Cancer
Cancer Trials Ireland
Not applicable
1,600
Dublin, Cork, Galway
2025-11-11
By invitation
Impact of Cooling Mats on Vasomotor Symptoms in Patients Receiving Endocrine Therapy
NCT07422727 Hot Flashes, Sleep, Hormonal, Cancer
Sligo General Hospital
Not applicable
40
Sligo
2025-11-10
Recruiting
DAREON ® -Lung-1: A Study in People With Advanced Small Cell Lung Cancer to Compare Obrixtamig Plus Atezolizumab, Carboplatin, and Etoposide Treatment With Standard Chemoimmunotherapy
NCT07472517 Small Cell Lung Cancer (SCLC), Extensive-stage Small Cell Lung Cancer (ES-SCLC)
DrugsObrixtamig·Etoposide·Atezolizumab·Carboplatin
Boehringer Ingelheim
Phase 3
670
Cork
2025-11-07
Recruiting
Remote Vital Sign Monitoring in Palliative Care Patients Using a Wearable ECG Monitor
NCT07512505 Cancer, Malignancies Multiple, Terminal Care, Hospice
Our Lady's Hospice and Care Services
Observational
120
Dublin
2025-11-06
Not yet open
An Exploratory Feasibility Study
NCT07009964 Well-Being, Lifestyle, Healthy, Young Adult, Behavior and Behavior Mechanisms
University College Dublin
Not applicable
12
Dublin
2025-11-01
Recruiting
A Long-Term Extension Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis (UC) or Crohn's Disease (CD)
NCT06405087 Ulcerative Colitis, Crohn's Disease
DrugVedolizumab
Takeda
Phase 3
70
Crumlin
2025-10-27
Recruiting
A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
NCT06793215 Non-Small Cell Lung Cancer, KRAS G12C Lung Cancer
DrugsDivarasib·Pemetrexed·Cisplatin·Carboplatin
Hoffmann-La Roche
Phase 3
600
Dublin
2025-10-24
Active, closed
A Study Comparing Navlimetostat (BMS-986504) in Combination With Nab-paclitaxel and Gemcitabine Versus Placebo in Combination With Nab-paclitaxel and Gemcitabine in Participants With Untreated Metastatic Pancreatic Ductal Adenocarcinoma With Homozygous MTAP Deletion (MountainTAP-30)
NCT07076121 Pancreatic Ductal Adenocarcinoma
DrugsNavlimetostat·Abraxane·Nab-paclitaxel·Gemcitabine
Bristol-Myers Squibb
Phase 2/3
470
Dublin
2025-10-23
Recruiting
A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer
NCT07213804 Ovarian Neoplasms, Fallopian Tube Neoplasms, Peritoneal Neoplasms, Neoplasm Metastasis
DrugsSofe-M·MIRV·Pegylated liposomal doxorubicin·Topotecan
Eli Lilly and Company
Phase 3
1,630
Cork, Dublin
2025-10-22
Recruiting
The Effect of α-GPC on Cognitive Function and Sports Performance
NCT07267845 Healthy Participants
Nanjing Nutrabuilding Bio-tech Co., Ltd.
Not applicable
80
Cork
2025-10-21
Recruiting
A Study of ZW251 in Participants With Advanced Solid Tumors
NCT07164313 Hepatocellular Carcinoma, Squamous Cell Non-Small Cell Lung Cancer, Germ Cell Tumor
Zymeworks BC Inc.
Phase 1
100
Dublin
2025-10-21
Recruiting
Effectiveness of Ultrasound-Guided Versus Traditional IV Insertion by Oncology Nurses in Adult Population Recieving Systemic Anti-cancer Therapy
NCT07208175 Cancer
University of Galway
Not applicable
98
Galway
2025-10-20
Recruiting
Study to Evaluate Subcutaneous (SC) VGA039 in Patients With Von Willebrand Disease (VWD)
NCT07115004 Von Willebrand Disease (VWD)
DrugVGA039
Vega Therapeutics, Inc
Phase 3
60
Dublin
2025-10-15
Recruiting
Open-Label Study to Evaluate the Safety, Tolerability, and Efficacy of Gene Therapy (SPVN20) in Subjects With Rod-Cone Dystrophy
NCT07807111 Retinitis Pigmentosa (RP), Rod Cone Dystrophy
SparingVision
Phase 1/2
27
Dublin
2025-10-08
Recruiting
The Lilac Device Trial - IMPACT: A Clinical Investigation on IMproving Peripheral Neuropathy Induced by Chemotherapy With Advanced Compression Technology - A Safety and Efficacy Study
NCT07142304 Chemotherapy Induced Peripheral Neuropathy (CIPN)
Luminate Medical, Inc.
Not applicable
142
Dublin
2025-10-03
Recruiting
CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis
NCT07207811 Transthyretin Amyloid Cardiomyopathy (ATTR CM)
DrugNNC6019-0001
Novo Nordisk A/S
Phase 3
1,280
Ballinasloe, Dublin, Letterkenny
2025-10-02
Recruiting
MCT Enteral Feeding to Reduce Chyle Leak After Oesophagectomy
NCT07616245 Oesphageal Cancer
Royal College of Surgeons, Ireland
Not applicable
160
Beaumont
2025-10-02
Recruiting
Evaluating the De-Escalation of Surveillance for Patients Who Have Undergone Curative Treatment for Primary Breast Cancer
NCT07616258 Breast Cancer
Royal College of Surgeons, Ireland
Not applicable
560
Beaumont
2025-10-02
Recruiting
HEM-iSMART-B: Dasatinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies
NCT05751044 Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory
DrugsDasatinib·Cytarabine·Venetoclax·Dexamethasone
Princess Maxima Center for Pediatric Oncology
Phase 1/2
26
Dublin
2025-10-01
Recruiting
Prediction of Venous Thrombosis During chemotherapy-the PINPOINT Study
NCT07196020 Venous Thromboembolism, Cancer
University of Dublin, Trinity College
Observational
380
Cork, Dublin
2025-10-01
Recruiting
HEM-iSMART-C: Ruxolitinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies
NCT05745714 Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory
DrugsRuxolitinib·Cytarabine·Venetoclax·Dexamethasone
Princess Maxima Center for Pediatric Oncology
Phase 1/2
26
Dublin
2025-10-01
Recruiting
Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer With Disease Progression on or After Immunotherapy
NCT07106762 Urothelial Cancer
DrugsIza-bren·Gemcitabine·Cisplatin·Carboplatin
Bristol-Myers Squibb
Phase 2/3
470
Cork, Dublin
2025-09-30
Recruiting
Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants With Primary Membranous Nephropathy (pMN)
NCT07204275 Primary Membranous Nephropathy
DrugsPovetacicept·Tacrolimus
Vertex Pharmaceuticals Incorporated
Phase 2/3
176
Cork, Dublin, Galway
2025-09-30
Recruiting
A Study Evaluating the Effects of Filgotinib in Children and Teenagers With Ulcerative Colitis
NCT06865417 Ulcerative Colitis
DrugFilgotinib
Alfasigma S.p.A.
Phase 3
80
Dublin
2025-09-29
Recruiting
Pre-infusion Aerobic Cycling Exercise for CardioRespiratory Fitness in Cancer Patients
NCT07182773 Cancer
University of Dublin, Trinity College
Not applicable
80
Dublin
2025-09-24
Recruiting
Streamlined Denervation With spYral For an Optimized Treatment (SPYRAL SWYFT) in Subjects With Uncontrolled Hypertension
NCT07115953 Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases
Medtronic Vascular
Not applicable
130
Dublin
2025-09-22
Recruiting
Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis
NCT07023835 Amyotrophic Lateral Sclerosis (ALS)
Zydus Therapeutics Inc.
Phase 2
240
Dublin
2025-09-17
Recruiting
Obstructive Sleep Apnoea and Difficult Asthma (OSADA)
NCT07160868 Asthma (Diagnosis), OSA - Obstructive Sleep Apnea, CPAP Treatment
St. James's Hospital, Ireland
Not applicable
80
Dublin
2025-09-01
Active, closed
eHealth Support Tool to Improve Quality of Life in Head and Neck Cancer Survivors
NCT07426874 Head and Neck Cancer (H&N)
Royal College of Surgeons, Ireland
Not applicable
30
Beaumont
2025-09-01
Active, closed
Mindful-Med: the Evaluation of the Mindfulness-based Stress-coping and Burnout Prevention Programme for Medical Interns.
NCT07171697 Stress (Psychology), Burnout, Mindfulness
Royal College of Surgeons, Ireland
Not applicable
24
Dublin
2025-09-01
Recruiting
AGENT DCB STANCE: Safety and Effectiveness Study of AGENT Drug-Coated Balloon Compared to Standard of Care Percutaneous Coronary Intervention (PCI) Treatment for de Novo Coronary Lesions
NCT06959524 Coronary Arterial Disease (CAD), de Novo Lesions in Native Coronary Arteries
Boston Scientific Corporation
Not applicable
1,616
Cork, Dublin, Galway
2025-08-21
Recruiting
The Satiety Control Optimization by Nutritional Enhancement Study
NCT07420023 Metabolic Diseases, Type 2 Diabetes, Cardiovascular Disease
University College Cork
Not applicable
24
Cork
2025-08-18
Recruiting
A Study of Barrett's Esophagus Patients to Investigate Quality of Life and Fear of Cancer, and Optimize a Risk Model Based on Biomarkers and New Technologies to Better Predict the Development of Cancer
NCT06523374 Barrett's Esophagus, Esophageal Adenocarcinoma
University Hospital, Antwerp
Not applicable
50
Dublin
2025-08-13
Recruiting
A Study of GSK5764227 in Participants With Relapsed Small Cell Lung Cancer (SCLC) [EMBOLD SCLC-301]
NCT07099898 Neoplasms, Lung
DrugsRis-Rez·Risvutatug rezetecan·Topotecan
GlaxoSmithKline
Phase 3
420
Dublin
2025-08-11
Recruiting
Randomised Trial of Dual Device Treatment Involving Drug-coated Balloon Angioplasty and Drug-eluting Stent Implantation Compared to Single Device Treatments in Patients With Diabetes Mellitus
NCT07303439 Diabetes Mellitus, Coronary Arterial Disease (CAD), de Novo Coronary Lesions, De Novo Stenosis
Royal College of Surgeons, Ireland
Not applicable
120
Dublin
2025-08-06
Recruiting
Ivosidenib and Azacitidine With or Without Venetoclax in Adult Patients With Newly Diagnosed IDH1-Mutated AML or MDS/AML Considered Ineligible for Intensive Chemotherapy
NCT07075016 Acute Myeloid Leukemia
Stichting Hemato-Oncologie voor Volwassenen Nederland
Phase 3
227
Cork, Dublin, Galway
2025-08-05
Recruiting
Comparison of 'Sip Til Send' Regimens Prior to Elective Caesarean Delivery Using Bedside Gastric Ultrasound
NCT07407530 Gastric Emptying, Caesarean Delivery, Pregnancy
The Rotunda Hospital
Not applicable
190
Dublin
2025-08-01
Not yet open
Frailty Intervention in Postoperative Hip Fracture Inpatients
NCT07027241 Hip Fractures (ICD-10 72.01-72.2), Frailty at Older Adults, Strength Training, Resistance Training
Royal College of Surgeons, Ireland
Not applicable
50
Waterford
2025-08-01
Not yet open
Gastric Emptying With Metoclopramide in GLP-1 Agonist Patients Undergoing Elective Surgery
NCT07100691 Pulmonary Aspiration During Anaesthetic Induction, Gastric Emptying Time, Preoperative Risk Assessment, Obesity (Disorder)
DrugMetoclopramide
Mater Misericordiae University Hospital
Phase 4
80
Dublin
2025-08
Recruiting
Harmony TPV EMEA PMS
NCT06906926 Severe Pulmonary Valve Regurgitation
Medtronic Cardiovascular
Not applicable
80
Dublin
2025-07-30
Active, closed
A Registry on the FARAVIEW Technology of the OPAL HDx Mapping System When Used With the FARAWAVE NAV Ablation Catheter in the Treatment of Atrial Fibrillation
NCT06808217 Atrial Fibrillation, Pulsed Field Ablation, FARAPULSE
Boston Scientific Corporation
Observational
550
Dublin
2025-07-30
Recruiting
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
NCT07064473 Diabetes Mellitus, Type 2, Hypertension, Cardiovascular Diseases
DrugsVicadrostat·Dapagliflozin
Boehringer Ingelheim
Phase 3
11,800
Ballinasloe, Dublin, Galway
2025-07-22
Recruiting
Sleep Promoting Properties of a Botanical Extract in a Population Complaining From Non-Restorative Sleep (NRS)
NCT07085819 Non Restorative Sleep, Sleep Disorder (Disorder)
Kerry Group P.L.C
Not applicable
160
Cork
2025-07-15
Recruiting
European Venous Registry
NCT06906250 Deep Venous Disease of the Lower Limbs
IRCCS San Raffaele
Observational
100
Galway
2025-07-05
Recruiting
A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)
NCT06863272 Castration-Resistant Prostatic Cancer, Metastasis
DrugsOpevesostat·Ifinatamab Deruxtecan·Abiraterone·Enzalutamide
Merck Sharp & Dohme LLC
Phase 1/2
360
Dublin
2025-07-03
Recruiting
TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
NCT07052903 Transthyretin Amyloidosis With Cardiomyopathy
DrugNucresiran
Alnylam Pharmaceuticals
Phase 3
1,750
Dublin
2025-07-02
Active, closed
A Study to Assess the Efficacy and Safety of Verekitug in Participants With COPD
NCT06981078 Chronic Obstructive Pulmonary Disease
DrugVerekitug
Upstream Bio Inc.
Phase 2
666
Dublin, Tallaght, Drogheda
2025-07-02
Recruiting
RECANA OUS - Recana Thrombectomy Catheter System for Venous Obstruction and Occlusion Study (RECANA-OUS-IRL)
NCT07095660 Venous Obstruction
Intervene, Inc.
Not applicable
20
Galway
2025-07-02
Active, closed
Safety Study of Viaskin® Peanut Patch in Peanut-Allergic Children 1 Through 3 Years of Age (COMFORT Toddlers)
NCT07003919 Allergy, Peanut Allergy
DBV Technologies
Phase 3
480
Cork, Dublin
2025-06-24
Active, closed
A Study to Assess the Change in Disease Activity in Adult Participants With Moderate to Severe Ulcerative Colitis Treated With Risankizumab Compared to Vedolizumab
NCT06880744 Ulcerative Colitis
DrugsRisankizumab·Vedolizumab
AbbVie
Phase 3
573
Ballinasloe, Drogheda, Mullingar, Dublin
2025-06-17
Recruiting
A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)
NCT06789913 PIK3CA-Related Overgrowth Spectrum (PROS), Lymphatic Malformations, Vascular Malformations, PIK3CA Mutation
DrugRLY-2608
Relay Therapeutics, Inc.
Phase 2
277
Dublin
2025-06-13
Recruiting
A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
NCT06943872 Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
DrugsSonrotoclax·Venclexta·Obinutuzumab·Venetoclax
BeOne Medicines
Phase 3
630
Dublin, Galway, Limerick
2025-06-11
Active, closed
A Study to Learn More About the Effects and Long-Term Safety of Omaveloxolone (BIIB141) in Children and Teens With Friedreich's Ataxia
NCT06953583 Friedreich Ataxia
DrugsOmaveloxolone·Skyclarys
Biogen
Phase 3
255
Dublin
2025-06-09
Recruiting
The AIRTIVITY™ Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis
NCT06872892 Bronchiectasis
DrugVerducatib
Boehringer Ingelheim
Phase 3
1,755
Cork, Dublin
2025-06-09
Recruiting
Spyral InSight Study
NCT07013929 Hypertension, Vascular Diseases, Cardiovascular Diseases
Medtronic Vascular
Not applicable
19
Galway
2025-06-09
Active, closed
A Study to Evaluate Axatilimab Versus Best Available Therapy in Participants With Chronic Graft Versus Host Disease After at Least 2 Prior Lines of Systemic Therapy
NCT06821542 Chronic Graft-versus-host-disease
DrugAxatilimab
Incyte Corporation
Phase 3
9
Dublin
2025-06-04
Recruiting
SURVEY-CNS: A Feasibility Study of Randomising Women and Men With HER2-Positive Metastatic Breast Cancer to Central Nervous System Surveillance Versus No Surveillance
NCT07503717 Breast Cancer, HER2-Positive Metastatic Breast Cancer
Royal College of Surgeons, Ireland
Not applicable
69
Beaumont
2025-06-01
Recruiting
A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)
NCT06952504 Endometrial Cancer
DrugsSacituzumab tirumotecan·Docetaxel·Keytruda·Paclitaxel
Merck Sharp & Dohme LLC
Phase 3
1,123
Dublin, Cork
2025-05-22
Active, closed
Long-term Study Evaluating Joint Health in People With Haemophilia A Receiving Real-world Prophylactic Treatment With Efanesoctocog Alfa
NCT06940830 Hemophilia A
DrugEfanesoctocog alfa
Swedish Orphan Biovitrum
Phase 4
252
Dublin
2025-05-21
Recruiting
The Lung Health Check Pilot
NCT07099027 Non-Small Cell Lung Cancer
Royal College of Surgeons, Ireland
Not applicable
2,183
Dublin
2025-05-19
Recruiting
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)
NCT06925737 Prostate Cancer, Prostatic Neoplasms
DrugsIfinatamab Deruxtecan·Prednisolone·Prednisone·Docetaxel
Merck Sharp & Dohme LLC
Phase 3
1,440
Dublin, Cork
2025-05-13
Recruiting
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
NCT06563895 Amyloidosis, Amyloid Cardiomyopathy, Transthyretin Amyloidosis, Cardiomyopathies
DrugAcoramidis
Eidos Therapeutics, a BridgeBio company
Phase 3
587
Dublin
2025-05-12
Recruiting
A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions
NCT06499285 Myelodysplastic Syndromes
DrugElritercept
Takeda
Phase 3
225
Cork, Dublin, Limerick
2025-05-06
Recruiting
VitaFlow LIBERTY Europe
NCT06535659 Aortic Valve Stenosis
Shanghai MicroPort CardioFlow Medtech Co., Ltd.
Observational
222
Galway
2025-05-06
Recruiting
Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)
NCT06881784 NSCLC (Non-small Cell Lung Cancer), Non-Small Cell Lung Cancer, NSCLC, NSCLC (Non-small Cell Lung Carcinoma)
DrugsCetuximab·Docetaxel
Revolution Medicines, Inc.
Phase 3
590
Cork, Dublin, Galway
2025-05-06
Recruiting
WISPer: Evaluation of MTX-463 in Participants With Idiopathic Pulmonary Fibrosis (IPF)
NCT06967805 Idiopathic Pulmonary Fibrosis
Mediar Therapeutics
Phase 2
164
Abbotstown, Drogheda, Dublin, Letterkenny
2025-05-05
Recruiting
Revumenib in Combination With Azacitidine + Venetoclax in Patients NPM1-mutated or KMT2A-rearranged AML
NCT06652438 Acute Myeloid Leukemia, Adult
DrugRevumenib
Stichting Hemato-Oncologie voor Volwassenen Nederland
Phase 3
448
Cork, Dublin, Galway, Waterford
2025-05-05
Active, closed
A Dose-Finding Study of Tebapivat to Assess Efficacy, and Safety in Participants With Sickle Cell Disease (SCD)
NCT06924970 Sickle Cell Disease
DrugTebapivat
Agios Pharmaceuticals, Inc.
Phase 2
59
Dublin
2025-05-01
Recruiting
SPYRAL GEMINI Pilot Study
NCT06907147 Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases
Medtronic Vascular
Not applicable
175
Galway
2025-05-01
Recruiting
PRospective phenotypIng and Multi-omic Endotyping of Progressive Pulmonary Fibrosis
NCT06855329 Progressive Pulmonary Fibrosis, Interstitial Lung Disease
University of Massachusetts, Worcester
Observational
500
Dublin
2025-05-01
Recruiting
A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
NCT06875310 Carcinoma, Non-Small-Cell Lung
DrugsAdagrasib·Pemetrexed·Keytruda·Cisplatin
Mirati Therapeutics Inc.
Phase 3
630
Cork, Dublin
2025-04-24
Recruiting
Single vs. Multiple Fraction Trial of Stereotactic Ablative Radiotherapy for Comprehensive Treatment of Oligometastases/Progression
NCT05784428 Oligometastatic Disease, Oligoprogression, Toxicity Due to Radiotherapy, Quality of Life
Robert Olson
Not applicable
598
Galway, Dublin, Cork, Waterford
2025-04-16
Recruiting
EXtubation Related Complications - the EXTUBE Study (EXTUBE)
NCT06442930 Extubation
University Health Network, Toronto
Observational
3,000
Castlebar, Cork, Dublin, Galway, Waterford
2025-04-14
By invitation
A Study to Learn About the Long-Term Health of Adult Participants From a Previous Study of a New Melanoma Treatment
NCT06848088 Melanoma
DrugsFianlimab·Cemiplimab
Regeneron Pharmaceuticals
Phase 2
48
Dublin
2025-04-14
Recruiting
A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)
NCT06890884 Lymphoma, Large B-Cell, Diffuse
DrugsRituximab Biosimilar·Zilovertamab vedotin·Riabni·Ruxience
Merck Sharp & Dohme LLC
Phase 2
594
Dublin, Limerick, Waterford
2025-04-11
Recruiting
A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer
NCT06868277 Carcinoma, Non-Small Cell Lung
DrugsRilvegostomig·Keytruda·Pembrolizumab
AstraZeneca
Phase 3
830
Cork, Dublin, Galway
2025-04-10
Recruiting
A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)
NCT06824467 Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
DrugsSteroid mouthwash (dexamethasone·Mvasi·Acetaminophen·Sacituzumab tirumotecan
Merck Sharp & Dohme LLC
Phase 3
770
Dublin
2025-04-09
Active, closed
Study of Bitopertin in Participants With EPP or XLP (APOLLO)
NCT06910358 Erythropoietic Protoporphyria (EPP), X-Linked Protoporphyria (XLP)
DrugBitopertin
Disc Medicine, Inc
Phase 3
183
Dublin
2025-04-04
Recruiting
A Study to Assess the Safety, Tolerability, and Efficacy of NDI-219216 in Patients With Advanced Solid Tumors.
NCT06898450 Advanced Solid Tumors Cancer, MSI-H Cancer
Nimbus Wadjet, Inc.
Phase 1/2
134
Dublin
2025-03-31
Recruiting
Randomised Clinical Trial to Investigate Efficacy and Safety of Benralizumab 30 mg SC as an add-on Therapy in Uncontrolled Eosinophilic Asthma Patients Treated With Medium-dose ICS-LABA Compared to Conventional Escalation to High-dose ICS-LABA Treatment
NCT06750289 Eosinophilic Asthma
AstraZeneca
Phase 3
400
Ballinasloe, Cork, Dublin, Moneymore
2025-03-28
Recruiting
Assessing Intellectual and Motor Outcomes in High-risk Infants
NCT06857539 Cerebral Palsy, Cerebral Palsy (CP), Cerebral Palsy Children, High-risk Infants
University College Cork
Observational
600
Cork, Dublin
2025-03-21
Active, closed
Study of Eftilagimod Alfa (Efti) in Combination With Pembrolizumab and Chemotherapy Versus Placebo in Combination With Pembrolizumab and Chemotherapy in Participants With Metastatic Non-Small Cell Lung Cancer (NSCLC) (TACTI-004)
NCT06726265 Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)
DrugsEfti·Pemetrexed·Keytruda·Paclitaxel
Immutep S.A.S.
Phase 3
756
Cork, Dublin
2025-03-21
Recruiting
Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
NCT07032662 Chronic Inflammatory Demyelinating Polyneuropathy
Immunovant Sciences GmbH
Phase 2
162
Waterford
2025-03-18
Active, closed
A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer
NCT06764485 Metastatic Castration-resistant Prostate Cancer
DrugsAbiraterone·Enzalutamide·Docetaxel
Celgene
Phase 3
960
Cork, Dublin
2025-03-13
Recruiting
Laparoscopic-Assisted Transversus Abdominus Plane Block Versus Intraperitoneal Irrigation of Local Anesthetic for Patients Undergoing Laparoscopic Cholecystectomy
NCT06714279 Laparoscopic Cholecystectomy, TAP Block, Local Anesthetic
Royal College of Surgeons, Ireland
Phase 1
144
Dublin
2025-03-12
Not yet open
An Educational Intervention to Improve the Success of Intubation in Newborns Using a Video Laryngoscope by Reducing the Time the Procedure Takes.
NCT06898801 Respiratory Distress Syndrome, Newborn, Endotracheal Intubation, Neonatal Intubation Performance, Prematurity
University College Dublin
Not applicable
140
Dublin
2025-03
Recruiting
A 3-part Study of SYX-5219 in Healthy Volunteers and Participants With Atopic Dermatitis
NCT07558668 Moderate to Severe Atopic Dermatitis
Sitryx Therapeutics Ltd
Phase 1
149
Dublin
2025-02-26
Recruiting
Inpatient Post-Acute Rehabilitation For Patients in the Midwest: a Prospective Cohort Study of Clinical Characteristics and Process Outcomes
NCT07351526 Rehabilitation, Frailty, Complex Patients in Rehabilitation Phase
University of Limerick
Observational
100
Limerick
2025-02-22
Recruiting
A Prospective Cohort Study of Clinical and Process Outcomes of Older Adults That Transition Through the Geriatric Emergency Medicine Unit(GEM-U)
NCT07237334 Frailty
University of Limerick
Observational
150
Limerick
2025-02-10
Active, closed
A Real-World Study to Gain Clinical Insights Into Faricimab (FaReal Study)
NCT06680817 Neovascular Age-related Macular Degeneration, Diabetic Macular Edema
DrugsVabysmo·Faricimab
Hoffmann-La Roche
Observational
875
Dublin, Limerick, Waterford
2025-02-05
Not yet open
Burnout and Resilience in Hospital-based Nursing and Medical Personnel and Trainees
NCT06818539 Stress, Burnout
University of Limerick
Observational
650
Limerick
2025-02-01
By invitation
Long-Term, Open-label Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults With HAE
NCT06679881 Hereditary Angioedema (HAE)
DrugDeucrictibant
Pharvaris Netherlands B.V.
Phase 3
170
Dublin
2025-02-01
Recruiting
An Ex-US Study to Assess Treatment Persistence With Risankizumab in Adult Participants With Psoriatic Arthritis
NCT06764693 Psoriatic Arthritis
AbbVie
Observational
1,200
Dublin, Elm Park, Tralee, Cork
2025-01-31
Recruiting
Inter- and Intraindividual Variability of the Acute Glucose Response to Exercise in Healthy Adults and People Living With Type 1 Diabetes: A Cross-over Replicate Trial
NCT07209930 Exercise, Healthy Participants, Glucose Variability, Type 1 Diabetes (T1D)
University College Dublin
Not applicable
24
Dublin
2025-01-28
Recruiting
FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
NCT06788990 Metastatic Head and Neck Squamous Cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma
DrugsFicerafusp alfa·Keytruda·Pembrolizumab
Bicara Therapeutics
Phase 2/3
650
Cork, Dublin
2025-01-28
Recruiting
A Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis or Crohn's Disease
NCT06100289 Ulcerative Colitis, Crohn's Disease
DrugVedolizumab
Takeda
Phase 3
70
Dublin
2025-01-22
Recruiting
A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease
NCT06585774 Chronic Graft-versus-host-disease
DrugsAxatilimab·Methylprednisolone·Prednisolone·Prednisone
Incyte Corporation
Phase 3
240
Dublin
2025-01-21
Active, closed
A Study of the Efficacy and Safety of Efgartigimod in Patients With Primary Sjögren's Syndrome
NCT06684847 Primary Sjogrens Disease
DrugEfgartigimod PH20
argenx
Phase 3
631
Dublin
2025-01-15
Recruiting
A Study to Evaluate the Benefit of Adding Durvalumab After Chemotherapy, Durvalumab and Surgery in Patients With Early-stage, Operable, Non-small Cell Lung Cancer.
NCT06284317 Non Small Cell Lung Cancer
ETOP IBCSG Partners Foundation
Phase 3
290
Dublin
2025-01-15
Not yet open
Rehab in Mild Stable DCM: Feasibility RCT Comparing Structured Rehabilitation to Clinical Surveillance
NCT06781658 Degenerative Cervical Myelopathy
Royal College of Surgeons, Ireland
Not applicable
24
Dublin
2025-01-13
Recruiting
A Phase 2 Efficacy and Safety Study of GAL-101, 2% Ophthalmic Solution in Non-foveal Geographic Atrophy Secondary to Non-neovascular AMD
NCT06659549 Geographic Atrophy of the Macula
Galimedix Therapeutics Inc
Phase 2
110
Kildare, Waterford
2025-01-10
Active, closed
Study of PF-07220060 With Letrozole in Adults With HR-positive HER2-negative Breast Cancer Who Have Not Received Anticancer Treatment for Advanced/Metastatic Disease
NCT06760637 Breast Cancer
DrugsAtirmociclib·Ribociclib·Abemaciclib·Palbociclib
Pfizer
Phase 3
1,035
Dublin
2025-01-06
Recruiting
A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease
NCT06227910 Crohn's Disease
DrugsVedolizumab·Upadacitinib
Takeda
Phase 3
396
Dublin
2025-01-02
Not yet open
AUGUR-AI - Indocyanine Green Fluorescence Angiography Representer
NCT06708819 Colorectal Surgery, Colorectal Resection, Anastomosis, Surgical, Fluorescence Guided Surgery
Mater Misericordiae University Hospital
Observational
300
Dublin
2025-01
Active, closed
Exoskeleton Training for Spinal Cord Injury Neuropathic Pain (ExSCIP)
NCT06463418 Traumatic Spinal Cord Injury
University College Dublin
Not applicable
40
Dublin
2024-12-20
Recruiting
A Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM)
NCT06679101 Multiple Myeloma, Newly Diagnosed Multiple Myeloma
DrugsBelantamab mafodotin·Daratumumab·Lenalidomide·Dexamethasone
GlaxoSmithKline
Phase 3
520
Dublin, Galway, Waterford
2024-12-16
Active, closed
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain
NCT06500455 Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Digestive System Carcinoma, Metastatic Lung Non-Small Cell Carcinoma
NRG Oncology
Phase 3
274
Dublin, Galway, Cork
2024-12-12
Recruiting
A Clinical Trial to Evaluate Efficacy and Safety of Navepegritide in Adolescents (12 - 18 Years of Age) With Achondroplasia.
NCT06732895 Achondroplasia
DrugNavepegritide
Ascendis Pharma A/S
Phase 2
24
Dublin
2024-12-10
By invitation
PIECES - Towards Large-Scale Adaptation and Tailored Implementation of Primary Cancer Prevention Programs
NCT06718322 Focus of Study: Tailored Implementation
Hidde van der Ploeg
Not applicable
100
Limerick
2024-12-01
Recruiting
SYMPHONY™ OCT System for Instabilities of the Upper Thoracic and Cervical Spine
NCT06816862 Cervical Instabilities Spine, Spine; Instability
University College Dublin
Observational
35
Dublin
2024-12-01
Active, closed
Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults With HAE
NCT06669754 Hereditary Angioedema (HAE)
DrugDeucrictibant
Pharvaris Netherlands B.V.
Phase 3
81
Dublin
2024-12-01
Active, closed
Trial to Evaluate Acasunlimab and Pembrolizumab Combination Superiority Over Standard of Care Docetaxel in Non-Small Cell Lung Cancer (ABBIL1TY NSCLC-06)
NCT06635824 PD-L1-positive, Locally Advanced (Unresectable Stage IIIB/C) or Metastatic NSCLC
DrugsDocetaxel·Pembrolizumab
Genmab
Phase 3
191
Cork, Dublin, Limerick, Waterford
2024-11-25
Recruiting
Measurement and Impact of Physical Impairment in Amyotrophic Lateral Sclerosis: Use of Digital Technologies - A Precision ALS Project
NCT06820008 Amyotrophic Lateral Sclerosis, Motor Neurone Disease
University of Dublin, Trinity College
Observational
60
Dublin
2024-11-21
Recruiting
CATALINA-2: A Clinical Study of TORL-1-23 in Platinum-resistant Ovarian Cancer.
NCT06690775 Epithelial Ovarian Cancer, Primary Peritoneal, Fallopian Tube Cancer, Endometrioid Ovarian Cancer
DrugsTORL-1-23·Pegfilgrastim
TORL Biotherapeutics, LLC
Phase 2
230
Dublin
2024-11-20
Active, closed
A Phase 2 Trial of ENV-101 in Patients With Lung Fibrosis (WHISTLE-PF Trial)
NCT06422884 Idiopathic Pulmonary Fibrosis, Progressive Fibrosing Interstitial Lung Disease
DrugTaladegib
Endeavor Biomedicines, Inc.
Phase 2
213
Dublin, Cork
2024-11-15
Recruiting
Testing the Effectiveness of a Work Rehabilitation Intervention for Women with Breast Cancer
NCT06723899 Breast Cancer
University of Dublin, Trinity College
Not applicable
248
Galway, Waterford
2024-11-13
Active, closed
A Study on Safety and Effectiveness of Long-term Treatment With Vamorolone in Boys With Duchenne Muscular Dystrophy
NCT06713135 Duchenne Muscular Dystrophy
DrugVamorolone
Santhera Pharmaceuticals
Phase 4
80
Dublin
2024-11-10
Recruiting
A Study of Vonicog Alfa (rVWF) in Children With Severe Von Willebrand Disease (vWD)
NCT05582993 Von Willebrand Disease (VWD)
DrugsAdvate·Vonicog Alfa
Takeda
Phase 3
24
Dublin
2024-11-06
Recruiting
AI-driven Narrow-band Imaging Score for Disease Assessment and Outcome Prediction in Ulcerative Colitis
NCT06709209 Ulcerative Colitis (UC)
University College Cork
Observational
300
Cork
2024-11-04
Recruiting
A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)
NCT06623422 Carcinoma, Non-Small-Cell Lung
DrugsIntismeran autogene·Paraplatin·Taxol·Pemetrexed
Merck Sharp & Dohme LLC
Phase 3
680
Cork, Dublin
2024-10-21
Recruiting
Heart Failure Virtual Ward Research Study
NCT06620653 Heart Failure
National University of Ireland, Galway, Ireland
Not applicable
346
Ballinasloe
2024-10-18
Recruiting
A Study to Assess the Efficacy and Safety of Efgartigimod IV in Adult Participants With Primary Immune Thrombocytopenia
NCT06544499 Primary Immune Thrombocytopenia (ITP)
DrugEfgartigimod
argenx
Phase 3
69
Dublin
2024-10-18
Active, closed
A Clinical Trial to Learn About the Effects of VHB937 in People With Amyotrophic Lateral Sclerosis (ALS)
NCT06643481 Amyotrophic Lateral Sclerosis (ALS)
DrugVHB937
Novartis Pharmaceuticals
Phase 2
251
Dublin
2024-10-17
Recruiting
A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis
NCT06598943 Ulcerative Colitis, Ulcerative Colitis Chronic
DrugsEltrekibart·Mirikizumab
Eli Lilly and Company
Phase 2
143
Dublin
2024-10-10
Recruiting
A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%
NCT06561386 Non-small Cell Lung Cancer
DrugsRelatlimab·Pemetrexed·Nivolumab·Cisplatin
Bristol-Myers Squibb
Phase 3
1,000
Dublin
2024-10-07
Recruiting
Efficacy of INM004 in Children With STEC-HUS
NCT06389474 Hemolytic-Uremic Syndrome
Inmunova S.A.
Phase 3
220
Dublin
2024-10-05
By invitation
Linguistically Tailored Health Messages to Encourage Plant-Based Food Choices in Adolescents
NCT06742346 Food Consumption, Sustainable Food Consumption, Sustainable Healthy Eating Behaviour
Erasmus University Rotterdam
Not applicable
600
London
2024-10-04
Recruiting
Microbiome Immunotherapy Neoadjuvant Assessment
NCT06709651 Triple Negative Breast Cancer
University College Cork
Observational
30
Cork
2024-10-02
Active, closed
Group-based Resistance Training for Adults With Down Syndrome
NCT07347912 Down Syndrome, Healthy Aging, Resistance Training
Saint John of God Intellectual Disability Services - Dublin South East
Not applicable
36
Dublin
2024-10-01
Recruiting
A Prospective Study of the Genomic Landscape of Central Nervous System Disease Secondary to Breast Cancer Utilising Cell-free DNA Derived From Cerebrospinal Fluid (CSF)
NCT07503704 Breast Cancer
Royal College of Surgeons, Ireland
Observational
69
Dublin
2024-10-01
Recruiting
ENVELOP: Wound Care Following Pilonidal Sinus Surgery
NCT06647290 Pilonidal Sinus, Wound Healing
Royal College of Surgeons, Ireland
Not applicable
200
Castlebar, Dublin, Kilkenny, Limerick, Tullamore, Waterford
2024-10-01
Recruiting
A Study in Adults to Learn About Inherited Alpha-1 Antitrypsin Deficiency (AATD) and AATD Related Liver Problems
NCT06512454 Alpha1-Antitrypsin Deficiency
Takeda
Observational
500
Dublin
2024-09-25
Recruiting
Implementation of a Standardized Algorithm for Coronary Calcification With Plaque Modification
NCT06678594 Myocardial Ischaemia, Severely Calcified Coronary Stenoses, Coronary Calcification
Royal College of Surgeons, Ireland
Observational
500
Dublin
2024-09-24
Active, closed
Safety and Tolerance of a Novel Three-Strain Probiotic in Healthy Adults
NCT07566884 Healthy Adults
Pendulum Therapeutics
Not applicable
30
Cork
2024-09-23
Recruiting
A Proof-of-Concept Study to Learn Whether Linvoseltamab Can Eliminate Abnormal Plasma Cells That May Lead to Multiple Myeloma in Adult Patients With High-Risk Monoclonal Gammopathy of Undetermined Significance or Non-High-Risk Smoldering Multiple Myeloma
NCT06140524 Monoclonal Gammopathy of Undetermined Significance (MGUS), Smoldering Multiple Myeloma (SMM)
DrugLinvoseltamab
Regeneron Pharmaceuticals
Phase 2
116
Galway, Cork, Dublin
2024-09-16
Recruiting
MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors
NCT06586515 Pancreatic Ductal Adenocarcinoma, Non-small Cell Lung Cancer, Colorectal Cancer
DrugsLeucovorin·Cetuximab·Irinotecan·Adrucil
Eli Lilly and Company
Phase 1
630
Dublin
2024-09-12
Recruiting
Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease
NCT06548542 Crohn's Disease
DrugsABBV-8736·Trosunilimab·Lutikizumab·Risankizumab
AbbVie
Phase 2
590
Letterkenny, Ballinasloe, Drogheda, Mullingar, Dublin
2024-09-04
Recruiting
Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)
NCT06274801 Pulmonary Arterial Hypertension
DrugSeralutinib
Gossamer Bio USA, Inc.
Phase 3
330
Dublin
2024-09-03
Recruiting
Community-based Exercise for Older Adults With Chronic Musculoskeletal Pain
NCT06535633 Chronic Musculoskeletal Pain
University of Limerick
Not applicable
72
Limerick
2024-09-01
Active, closed
Evaluation of Efficacy of Povetacicept in Adults With Immunoglobulin A Nephropathy (IgAN)
NCT06564142 Immunoglobulin A Nephropathy
DrugPovetacicept
Alpine Immune Sciences Inc, A Subsidiary of Vertex
Phase 3
605
Cork, Dublin, Galway, Waterford
2024-08-30
Recruiting
Investigating Mechanistic Predictors of Interpatient Variability and Temozolomide (TMZ) Induced Haematological Toxicity for Glioma Patients
NCT06546631 Glioma
University College Cork
Observational
55
Cork
2024-08-22
Recruiting
Abbott Structural Heart Device Registry
NCT06590467 Heart Diseases, ASD - Atrial Septal Defect, VSD - Muscular Ventricular Septal Defect, PFO - Patent Foramen Ovale
Abbott Medical Devices
Observational
2,500
Crumlin
2024-08-21
Recruiting
Prophylactic Surfactant by Thin Endotracheal Catheter for Preterm Infants At Birth: the ProTeCt Trial
NCT06557551 Infant, Newborn, Diseases, Prematurity, Prematurity; Extreme, Respiratory Distress Syndrome in Premature Infant
University College Dublin
Not applicable
164
Dublin
2024-08-19
By invitation
Sleep Well At Night
NCT07068971 Sleep Disturbance in Advanced Cancer
Our Lady's Hospice and Care Services
Not applicable
30
Dublin
2024-08-19
By invitation
Impact of Aromatherapy on Wellbeing and Relaxation in Gynae Oncology Patients Post Treatment
NCT06590077 Stress, Wellbeing, Relaxation
University of Dublin, Trinity College
Not applicable
40
Dublin
2024-08-19
Recruiting
A Motor Learning Intervention to Target Walking Performance in Ambulant Children With Cerebral Palsy
NCT06454656 Cerebral Palsy, Walking, Difficulty, Spastic Diplegia, Hemiplegic Cerebral Palsy
Royal College of Surgeons, Ireland
Not applicable
14
Balrath
2024-08-12
Recruiting
Real World Data Collection on the Synergy Disc
NCT06383949 Cervical Degenerative Disc Disease
Synergy Spine Solutions
Observational
50
Dublin
2024-08-06
Recruiting
Preventing Cardiovascular Collapse With Vasopressors During Tracheal Intubation
NCT05014581 Critical Illness, Respiratory Failure
DrugsNoradrenaline·Norepinephrine
University of Turin, Italy
Phase 3
420
Galway
2024-08-01
Recruiting
The Effect of a Post-operative Exercise Programme Versus Standard Care on Physical Fitness of Patients With Breast Cancer Undergoing Deep Inferior Epigastric Perforator (DIEP) Flap Reconstruction Surgery
NCT07672392 Breast Cancer, Exercise
Royal College of Surgeons, Ireland
Not applicable
78
Beaumont
2024-08-01
Active, closed
A Study of Ocular Toxicity Evaluation and Mitigation During Treatment With Mirvetuximab Soravtansine in Participants With Recurrent Ovarian Cancer With High Folate Receptor-Alpha Expression
NCT06365853 Recurrent Ovarian Cancer, Folate Receptor-Alpha Positive
DrugsMIRV·Mirvetuximab Soravtansine
AbbVie
Phase 2
108
Dublin
2024-07-29
Active, closed
A Phase 2 Clinical Trial to Evaluate Efficacy, Safety, and Tolerability of Navepegritide in Combination With Lonapegsomatropin in Children With Achondroplasia
NCT06433557 Achondroplasia
Ascendis Pharma Growth Disorders A/S
Phase 2
22
Dublin
2024-07-26
Active, closed
A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)
NCT06459180 Cervical Cancer
DrugsTisotumab Vedotin·Vinorelbine·Topotecan·Sacituzumab tirumotecan
Merck Sharp & Dohme LLC
Phase 3
686
Cork, Dublin
2024-07-24
Recruiting
TreatHSP Platform: Adaptive Natural History Platform for Ataxias, HSPs, and Spastic Ataxias
NCT07798674 Hereditary Spastic Paraplegia, Spastic Ataxia
Heidelberg University
Observational
4,000
Dublin
2024-07-16
Recruiting
Fibrosis Lessens After Metabolic Surgery
NCT06374875 Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD), Non-Alcoholic Fatty Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis (MASH), Liver Fibrosis
The Cleveland Clinic
Phase 4
120
Dublin
2024-07-11
Active, closed
SalT Supplementation in Older Adults With Orthostatic Intolerance Disorders
NCT06188663 Orthostatic Hypotension
University of Galway
Phase 2
42
Galway
2024-07-09
Recruiting
CONDUIT™ Anterior Lumbar Interbody Fusion (ALIF) Cage System in Lumbar Degenerative Disease
NCT06940453 Lumbar Degenerative Disease
University College Dublin
Observational
35
Dublin
2024-06-28
Active, closed
A Study to Assess Disease Activity and Safety of Lutikizumab in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa
NCT06468228 Hidradenitis Suppurativa
DrugLutikizumab
AbbVie
Phase 3
1,400
Drogheda, Cork, Dublin
2024-06-27
Recruiting
Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)
NCT06393374 Triple-Negative Breast Cancer
DrugsXeloda·Sacituzumab tirumotecan·Keytruda·Capecitabine
Merck Sharp & Dohme LLC
Phase 3
1,530
Cork, Dublin, Galway
2024-06-24
Active, closed
Long-term, Open-label Study of SAR447537 (INBRX-101) in Adults With Alpha-1 Antitrypsin Deficiency Emphysema
NCT05897424 Alpha 1-Antitrypsin Deficiency, Emphysema
Sanofi
Phase 2
185
Dublin
2024-06-20
Recruiting
A Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD)
NCT06389877 Alpha 1-Antitrypsin Deficiency
Beam Therapeutics Inc.
Phase 1/2
106
Dublin
2024-06-19
Recruiting
A Trial to Evaluate the Efficacy and Safety of Tralokinumab in Combination With Topical Corticosteroids in Children and Infants With Moderate-to-severe Atopic Dermatitis
NCT06311682 Atopic Dermatitis
DrugTralokinumab
LEO Pharma
Phase 3
195
Cork, Crumlin
2024-06-10
Recruiting
Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]
NCT06422143 Non-small Cell Lung Cancer, NSCLC
DrugsSacituzumab tirumotecan·Nab-paclitaxel·Keytruda·Paclitaxel
Merck Sharp & Dohme LLC
Phase 3
851
Dublin
2024-06-10
Active, closed
The Effect of an Adhesive System on the Retention and Caries Prevention for Fissure Sealants in Permanent Molars
NCT06608563 Dental Caries, Fissure Sealant
University of Dublin, Trinity College
Not applicable
100
Dublin
2024-06-05
Active, closed
Study Comparing Tarlatamab and Durvalumab Versus Durvalumab Alone in First-Line Extensive-Stage Small-Cell Lung Cancer (ES-SCLC) Following Platinum, Etoposide and Durvalumab
NCT06211036 Extensive-Stage Small-Cell Lung Cancer, Small-Cell Lung Cancer
DrugsTarlatamab·Durvalumab
Amgen
Phase 3
563
Dublin
2024-06-05
Recruiting
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
NCT06430801 Crohn's Disease
DrugTulisokibart
Merck Sharp & Dohme LLC
Phase 3
1,200
Dublin
2024-06-05
By invitation
Prostate Cancer Awareness and Initiative for Screening in the European Union
NCT06424275 Prostate Cancer
European Association of Urology Research Foundation
Observational
20,000
Dublin
2024-06-01
Not yet open
Evaluating a Targeted Selective Speech, Language, and Communication Intervention at Scale - Protocol for the 'Happy Talk' Cluster Randomised Controlled Trial.
NCT06460090 Developmental Language Disorder and Language Impairment, Deprivation
University College Cork
Not applicable
840
Dublin, Galway, Wexford, Wicklow
2024-06
Active, closed
Cognition in Older Adults With Cancer Receiving Systemic Anti-Cancer Therapy
NCT07411105 Cancer, Older Adults (65 Years and Older), Cognition
Our Lady's Hospice and Care Services
Observational
30
Dublin
2024-05-21
Recruiting
Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)
NCT06353386 Prostatic Neoplasms, Castration-Resistant
DrugsFludrocortisone acetate·Opevesostat·Cabazitaxel·Taxotere
Merck Sharp & Dohme LLC
Phase 1/2
220
Dublin, Cork
2024-05-20
Recruiting
VE303 for Prevention of Recurrent Clostridioides Difficile Infection
NCT06237452 Clostridium Difficile, Clostridium Difficile Infections, Clostridium Difficile Infection Recurrence, Clostridioides Difficile Infection
Vedanta Biosciences, Inc.
Phase 3
852
Dublin, Drogheda
2024-05-20
Recruiting
A Probiotic Strategy for Antipsychotic-induced Metabolic Dysfunction
NCT06729671 Psychosis
University College Cork
Not applicable
70
Cork
2024-05-16
Active, closed
A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast
NCT06238622 Idiopathic Pulmonary Fibrosis, Progressive Pulmonary Fibrosis
DrugNerandomilast
Boehringer Ingelheim
Phase 3
1,666
Dublin
2024-05-06
Recruiting
Exploring the Impact of a Multi-modal Nutritional Intervention in Patients Undergoing Chemotherapy for Pancreatic Cancer (FEED Trial)
NCT06149546 Pancreatic Cancer
Cancer Trials Ireland
Not applicable
70
Dublin
2024-05-01
By invitation
A Long-term Extension Study to Assess the Long-term Safety and Efficacy of Pegtibatinase Treatment in Participants ≥5 to ≤65 Years of Age With Classical Homocystinuria (HCU) (ENSEMBLE)
NCT06431893 Homocystinuria
DrugPegtibatinase
Travere Therapeutics, Inc.
Phase 3
100
Dublin
2024-04-30
Recruiting
A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer
NCT06319820 Non-Muscle Invasive Bladder Neoplasms
DrugGemcitabine
Janssen Research & Development, LLC
Phase 3
641
Cork, Dublin
2024-04-18
Active, closed
A Study to Evaluate Mavacamten in Adolescents With Symptomatic Obstructive Hypertrophic Cardiomyopathy
NCT06253221 Cardiomyopathy, Hypertrophic
DrugMavacamten
Bristol-Myers Squibb
Phase 3
44
Dublin 12, D12 N512
2024-04-17
Recruiting
A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)
NCT06312176 Breast Neoplasms
DrugsLiposomal doxorubicin·Abraxane·Xeloda·Sacituzumab tirumotecan
Merck Sharp & Dohme LLC
Phase 3
1,200
Cork, Dublin
2024-04-14
Recruiting
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
NCT06330064 Recurrent or Metastatic Solid Tumors
DrugIfinatamab Deruxtecan
Daiichi Sankyo
Phase 1/2
680
Dublin, Cork, Galway
2024-04-10
Active, closed
An International, Multicenter, Randomized, Double-Blind, Parallel Group, Vehicle-Controlled, Phase 2/3 Study With Open-Label Extension Evaluating the Efficacy and Safety of Diacerein 1% Ointment for the Treatment of Generalized Epidermolysis Bullosa Simplex (EBS)
NCT06073132 Generalized Epidermolysis Bullosa Simplex
TWi Biotechnology, Inc.
Phase 2/3
80
Dublin
2024-04-04
Recruiting
Remote Assessment of Signs and Symptoms in Palliative Care
NCT06587321 Palliative Care, Vital Signs, Remote Monitoring
Our Lady's Hospice and Care Services
Observational
30
Dublin
2024-04-01
Recruiting
PENG Block: Continuous Infusion vs. Programmed Intermittent Bolus in Neck of Femur Fracture
NCT07046052 Hip Fracture, Analgesia Post Fracture
University College Cork
Not applicable
150
Cork
2024-03-28
Recruiting
Study on Efficacy and Safety of Givinostat Versus Hydroxyurea in Patients With Polycythemia Vera
NCT06093672 Polycythemia Vera
DrugHydroxyurea
Italfarmaco
Phase 3
220
Cork, Dublin
2024-03-26
Recruiting
A Phase 1/1b Study of IAM1363 in HER2 Cancers
NCT06253871 HER2 Mutation-Related Tumors, HER2, HER2-positive Breast Cancer, HER2 + Breast Cancer
Iambic Therapeutics, Inc
Phase 1
383
Dublin, Cork
2024-03-25
Active, closed
A Study to Assess Adverse Events and Change in Disease Activity From Intravenous (IV) and Subcutaneous (SC) Lutikizumab in Adult Participants With Active Ulcerative Colitis
NCT06257875 Ulcerative Colitis
DrugsLutikizumab·Humira·Adalimumab
AbbVie
Phase 2
156
Elm Park, Dublin
2024-03-23
Active, closed
Essilor® Stellest® Lenses Multicentre European Study (SLOMES)
NCT06263946 Myopia
Essilor International
Not applicable
150
Dublin
2024-03-22
Recruiting
A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer
NCT06072781 Low Grade Serous Ovarian Cancer
DrugsAvutometinib·Defactinib·Pegylated liposomal doxorubicin·Anastrozole
Verastem, Inc.
Phase 3
270
Dublin
2024-03-18
Recruiting
The NEU-STIM Trial
NCT05942924 Infant, Premature, Diseases, Birth, Preterm
Leiden University Medical Center
Not applicable
3,280
Dublin, Galway
2024-03-11
By invitation
School-aged Outcomes Post Hypoxic Ischaemic Encephalopathy
NCT07770035 Hypoxic-Ischemic Encephalopathy
University College Cork
Observational
196
Cork
2024-03-09
Active, closed
ProVIDE II Bridging Study
NCT06236802 BPH With Symptomatic Lower Urinary Tract Symptoms
ProVerum Medical
Not applicable
40
Dublin
2024-03-06
Recruiting
H. Pylori Screen-and-treat Study in a Population of Young Adults
NCT06275204 Gastric Cancer, H Pylori Infection, H Pylori Eradication, H-pylori
University of Latvia
Observational
6,800
Dublin
2024-03-04
Recruiting
A Study of Sepiapterin in Participants With Phenylketonuria (PKU)
NCT06302348 Phenylketonuria
PTC Therapeutics
Phase 3
56
Dublin
2024-03-04
Recruiting
PINTA - Prophylactic Incisional Negative Pressure Therapy for Major Amputations
NCT06025253 Wound Surgical, Wound Infection, Cosmesis
Royal College of Surgeons, Ireland
Not applicable
728
Dublin, Galway, Limerick, Waterford
2024-03-01
Recruiting
Supporting University Students Transition Towards Sustainable and Healthy Dietary Behaviours: A Living Lab Approach.
NCT06939231 Dietary Behaviours, Sustainable Healthy Diet, Personalised Nutrition
University College Dublin
Not applicable
520
Dublin
2024-02-26
Active, closed
A Study to Evaluate the Efficacy, Safety, and Tolerability of Using an Oral Once-daily 2 Drug Regimen Compared to an Oral Once-daily 3 Drug Regimen for the Treatment of Human Immunodeficiency Virus (HIV)-1 in Adults Who Have Not Previously Taken Antiretroviral Therapy
NCT05979311 HIV, HIV Infections
DrugsBictegravir·Emtricitabine·Dolutegravir·Lamivudine
ViiV Healthcare
Phase 3
307
Dublin
2024-02-21
Active, closed
Study to Assess Speed of Onset and Durability of Effectiveness of Upadacitinib in Adult Participants With Moderate to Severe Crohn's Disease (CD) in Real World Clinical Practice.
NCT05930275 Crohn's Disease
AbbVie
Observational
1,200
Ballinasloe, Dublin
2024-02-19
Recruiting
The Effects of Exercise on Gut Bacteria, Mood and Cognition in Depression
NCT06398496 Depressive Disorder, Major
University College Cork
Not applicable
40
Cork
2024-02-14
Active, closed
Assessment of Diastolic Function During the Transitional Period and Infancy Using Serial Echocardiography
NCT06200519 Diastolic Dysfunction, Neonatal Encephalopathy, Small for Gestational Age at Delivery, Transient Tachypnea of the Newborn
University College Cork
Observational
216
Cork
2024-02-12
Recruiting
Dose-Painted Intensity Modulated Radiotherapy Pancreas (DP-IMRT Pancreas)
NCT06024824 Pancreatic Adenocarcinoma
Cancer Trials Ireland
Phase 1/2
49
Dublin
2024-01-30
Recruiting
A Clinical Trial to Evaluate Efficacy and Safety of TransCon CNP Compared With Placebo in Infants (0 to <2 Years of Age) With Achondroplasia
NCT06079398 Achondroplasia
DrugNavepegritide
Ascendis Pharma A/S
Phase 2
72
Dublin
2024-01-23
Recruiting
A Study of Roxadustat to Treat Anemia in Children and Teenagers With Chronic Kidney Disease
NCT05970172 Chronic Kidney Disease, Renal Anemia
DrugRoxadustat
Astellas Pharma Global Development, Inc.
Phase 3
100
Dublin
2024-01-16
Recruiting
International obServational sTudy on AiRway manaGement in operAting Room and Non-operaTing Room anaEsthesia
NCT05759299 Airway Complication of Anesthesia
University of Turin, Italy
Observational
10,500
Galway
2024-01-15
Active, closed
The Impact of Domiciliary Versus 'Hub' Based Comprehensive Geriatric Assessment on Clinical and Process Outcomes Among Older Adults Attending Community Specialist Teams: a Randomised Controlled Trial.
NCT06205238 Frailty, Comprehensive Geriatric Assessment, Older Adults, Domiciliary Care
University of Limerick
Not applicable
106
Limerick
2024-01-15
Active, closed
Study of ALXN2220 Versus Placebo in Adults With ATTR-CM
NCT06183931 Transthyretin Amyloid Cardiomyopathy
DrugCliramitug
Alexion Pharmaceuticals, Inc.
Phase 3
1,181
Dublin
2024-01-11
Recruiting
Occupational Therapy-led Services for Adults Presenting Acutely With a Hand Condition
NCT06399614 Hand Injuries
University of Limerick
Observational
150
Dublin, Galway, Limerick, Tipperary
2024-01-11
Recruiting
PICSI Impact on Euploidy in Assisted Reproduction
NCT06602687 Infertility
Merrion Fertility Clinic
Not applicable
142
Dublin
2024-01-01
Recruiting
Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)
NCT06136624 Prostate Cancer Metastatic
DrugsFludrocortisone acetate·Opevesostat·Zytiga·Hydrocortisone
Merck Sharp & Dohme LLC
Phase 3
1,310
Dublin
2023-12-31
Recruiting
Trastuzumab Deruxtecan (T-DXd) in Patients Who Have Hormone Receptor-negative and Hormone Receptor-positive HER2-low or HER2 IHC 0 Metastatic Breast Cancer
NCT05950945 Breast Cancer
DrugTrastuzumab deruxtecan
Daiichi Sankyo
Phase 3
250
Cork, Dublin, Galway
2023-12-30
Recruiting
Pegtibatinase as a Treatment for Participants With Classical Homocystinuria (HCU) Receiving Standard of Care Treatment
NCT06247085 Homocystinuria
DrugPegtibatinase
Travere Therapeutics, Inc.
Phase 3
70
Dublin
2023-12-28
Recruiting
Affera Global Registry
NCT06026345 Atrial Fibrillation
Medtronic Cardiac Ablation Solutions
Observational
540
Dublin
2023-12-22
Recruiting
A Study of Nipocalimab in Pregnancies at Risk for Severe Hemolytic Disease of the Fetus and Newborn (HDFN)
NCT05912517 Hemolytic Disease of the Fetus and Newborn
DrugNipocalimab
Janssen Research & Development, LLC
Phase 3
120
Dublin
2023-12-20
Recruiting
A Study of Clinical Outcomes in Patients With Relapsed/Refractory Multiple Myeloma (RRMM) Treated With T-cell Redirectors Outside of Clinical Trials
NCT06285318 Relapsed/Refractory Multiple Myeloma (RRMM)
Janssen-Cilag Ltd.
Observational
900
Cork, Dublin, Galway
2023-12-18
Recruiting
A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)
NCT06136650 Metastatic Castration-resistant Prostate Cancer (mCRPC), Prostatic Neoplasms
DrugsFludrocortisone acetate·Opevesostat·Prednisone Acetate·Zytiga
Merck Sharp & Dohme LLC
Phase 3
1,314
Dublin
2023-12-18
Recruiting
Elacestrant for Treating ER+/HER2- Breast Cancer Patients With ctDNA Relapse (TREAT ctDNA)
NCT05512364 ER-positive Breast Cancer, HER2-negative Breast Cancer, Stage IIB Breast Cancer, Stage III Breast Cancer
DrugsElacestrant·Tamoxifen·Exemestane·Anastrozole
European Organisation for Research and Treatment of Cancer - EORTC
Phase 3
220
Dublin, Waterford
2023-12-15
Recruiting
A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell Lymphoma
NCT06091865 Diffuse Large B-cell Lymphoma (DLBCL)
DrugsOdronextamab·Prednisone/Prednisolone·Adriamycin·Cytoxan
Regeneron Pharmaceuticals
Phase 3
904
Dublin
2023-12-13
Active, closed
A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)
NCT06077760 Non-small Cell Lung Cancer
DrugsIntismeran autogene·Keytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
868
Dublin
2023-12-06
Active, closed
Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005)
NCT06132958 Endometrial Cancer
DrugsAbraxane·Adriamycin·Sacituzumab tirumotecan·Taxol
Merck Sharp & Dohme LLC
Phase 3
710
Cork, Dublin
2023-12-06
Active, closed
U011 - Wireless Ultra Long-Term EEG Recordings in Epilepsy
NCT05915988 Epilepsy
UNEEG Medical A/S
Not applicable
19
Cork, Dublin
2023-12-04
Recruiting
PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
NCT05934487 Heart Failure NYHA Class II, Heart Failure NYHA Class III, Heart Failure
Endotronix, Inc.
Not applicable
1,750
Galway
2023-11-29
Recruiting
Spine SABR - Dose-escalated Stereotactic Ablative Body Radiotherapy (SABR) for Solid Tumour Spine Metastases
NCT06078813 Solid Tumor Spine Metastases
Cancer Trials Ireland
Phase 1/2
126
Cork, Dublin
2023-11-21
Recruiting
HEM iSMART-D: Trametinib + Dexamethasone + Chemotherapy in Children With Relapsed or Refractory Hematological Malignancies
NCT05658640 Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory
DrugsTrametinib·Cytarabine·Dexamethasone·Cyclophosphamide
Princess Maxima Center for Pediatric Oncology
Phase 1/2
26
Dublin
2023-11-14
Not yet open
Surveillance After Resection of Oesophageal aNd Gastric Cancer (SARONG-II) Trial
NCT06115629 Esophageal Cancer, Gastric Cancer
University of Dublin, Trinity College
Phase 3
952
Cork, Dublin, Galway
2023-11
Not yet open
Study Comparing Platelet Transfusion Volumes in Premature Babies
NCT06095648 Thrombocytopenia, Transfusion
University College Dublin
Not applicable
370
Dublin
2023-10-28
Recruiting
Pregnancy Exposure Registry for Vumerity (Diroximel Fumarate)
NCT05658497 Multiple Sclerosis
DrugsDiroximel Fumarate·Natalizumab·Avonex·Dimethyl Fumarate
Biogen
Observational
908
Dublin
2023-10-27
Recruiting
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients
NCT05899608 Non-Small Cell Lung Cancer
DrugsIvonescimab·Pembrolizumab
Summit Therapeutics
Phase 3
1,600
Dublin, Galway
2023-10-26
Active, closed
Neoadjuvant Trastuzumab Deruxtecan (T-DXd) With Response-directed Definitive Therapy in Early Stage HER2-positive Breast Cancer (SHAMROCK Study)
NCT05710666 HER2-positive Breast Cancer
DrugTrastuzumab deruxtecan
Cancer Trials Ireland
Phase 2
11
Galway, Dublin, Cork, Limerick
2023-10-26
Active, closed
A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Progressive Pulmonary Fibrosis
NCT06025578 Progressive Pulmonary Fibrosis
DrugAdmilparant
Bristol-Myers Squibb
Phase 3
1,057
Drogheda, Dublin
2023-10-25
Recruiting
The Impact of E-cigarettes During Pregnancy on Childhood Health Outcomes Study
NCT06297005 Vaping, Pregnancy Related, Pediatric Respiratory Diseases
University College Dublin
Observational
1,200
Dublin
2023-10-09
Active, closed
An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)
NCT05952557 Breast Cancer, Early Breast Cancer
DrugsCamizestrant·Tamoxifen·Exemestane·Anastrozole
AstraZeneca
Phase 3
5,511
Cork, Dublin, Galway, Waterford
2023-10-05
Recruiting
Palliative Care and Oncology Survey on Terminology
NCT05871996 Cancer
Our Lady's Hospice and Care Services
Observational
1,532
Dublin
2023-10-03
Active, closed
Disitamab Vedotin With Pembrolizumab vs Chemotherapy in Previously Untreated Urothelial Cancer Expressing HER2
NCT05911295 Urothelial Carcinoma
DrugsDisitamab Vedotin·Keytruda·Gemcitabine·Cisplatin
Seagen, a wholly owned subsidiary of Pfizer
Phase 3
412
Tallaght
2023-09-22
Active, closed
A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Idiopathic Pulmonary Fibrosis
NCT06003426 Idiopathic Pulmonary Fibrosis
DrugAdmilparant
Bristol-Myers Squibb
Phase 3
1,255
Drogheda, Dublin
2023-09-14
By invitation
A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Active Idiopathic Inflammatory Myopathy
NCT05979441 Myositis, Active Idiopathic Inflammatory Myopathy, Dermatomyositis, Polymyositis
DrugEfgartigimod PH20
argenx
Phase 3
240
Dublin
2023-09-12
Recruiting
Efficacy and Safety of Trimodulin (BT588) in Subjects With Severe Community-acquired Pneumonia (sCAP)
NCT05722938 Community-acquired Pneumonia
Biotest
Phase 3
590
Dublin, Galway
2023-09-09
By invitation
HELIOS: Open-Label, Long-Term Extension Study to Investigate the Safety, Tolerability, and Efficacy of DISC-1459 (Bitopertin) in Participants With EPP or XLP
NCT05883748 Erythropoietic Protoporphyria
DrugBitopertin
Disc Medicine, Inc
Phase 2/3
230
Dublin
2023-08-31
By invitation
Long-term Follow-up Study of Male Adults With Hemophilia B Previously Treated With Etranacogene Dezaparvovec (CSL222)
NCT05962398 Hemophilia B
CSL Behring
Observational
56
Dublin
2023-08-30
Recruiting
Discontinuation Study
NCT05866757 Multiple Myeloma, Cancer, Hematologic Cancer
University College Cork
Not applicable
70
Cork
2023-08-28
Active, closed
Sedation, Temperature and Pressure After Cardiac Arrest and Resuscitation
NCT05564754 Cardiac Arrest With Successful Resuscitation, Hypoxia, Brain
Region Skane
Not applicable
3,500
Dublin
2023-08-17
Active, closed
BioDulse II: The Effect of an Irish Seaweed Protein Extract on Glucose Control in Adults With Type 2 Diabetes
NCT05986253 Type 2 Diabetes
University of Limerick
Not applicable
10
Limerick
2023-08-07
Active, closed
PROPEL-2: Prophylactic Negative Pressure Wound Therapy in Laparotomy Wounds
NCT05977816 Wound Surgical, Wound Infection, Cosmesis
Royal College of Surgeons, Ireland
Not applicable
2,000
Castlebar, Dublin, Galway, Letterkenny, Limerick, Sligo, Waterford
2023-07-14
Recruiting
Early Detection & Intervention of Cerebral Palsy in Ireland
NCT05907837 Cerebral Palsy, Neurodevelopmental Disorders
University College Cork
Observational
1,500
Cork, Dublin, Limerick
2023-07-01
Recruiting
Friedreich Ataxia Global Clinical Consortium UNIFIED Natural History Study
NCT06016946 Friedreich Ataxia
Friedreich's Ataxia Research Alliance
Observational
3,000
Dublin
2023-06-28
Active, closed
Satisfaction, QoL,Health Status & Clinic Outcomes for Patients Attending MSK Triage Clinics in Rheumatology
NCT04244968 Musculoskeletal Pain, Rheumatologic Disorder
Health Service Executive, Ireland
Observational
325
Sligo
2023-06-22
By invitation
A Clinical Trial to Investigate Long-term Safety, Tolerability, and Efficacy of Weekly Subcutaneous Doses With TransCon CNP in Children and Adolescents With Achondroplasia
NCT05929807 Achondroplasia
Ascendis Pharma Growth Disorders A/S
Phase 2/3
140
Dublin
2023-06-21
Active, closed
A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy
NCT05889182 Hidradenitis Suppurativa
DrugUpadacitinib
AbbVie
Phase 3
1,328
Dublin, Cork, Galway, Waterford
2023-06-21
Active, closed
Adagrasib in Patients With KRASG12C-mutant NSCLC Who Are Elderly or Have Poor Performance Status
NCT05673187 NSCLC Stage IV, KRAS P.G12C
DrugAdagrasib
ETOP IBCSG Partners Foundation
Phase 2
68
Dublin, Limerick, Waterford
2023-06-12
Active, closed
Prospective Observational Study of Effectiveness and Safety of Filgotinib in Participants With Ulcerative Colitis (UC)
NCT05817942 Ulcerative Colitis
DrugFilgotinib
Alfasigma S.p.A.
Observational
509
Cork, Dublin
2023-06-12
Recruiting
"Physiological vs Right Ventricular Pacing Outcome Trial Evaluated for bradyCardia Treatment" (PROTECT-HF)
NCT05815745 Bradycardia, Pacing, Right Ventricular Pacing, His Bundle Pacing
Imperial College London
Not applicable
2,600
Dublin
2023-06-05
Recruiting
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
NCT05714085 Heart Failure, Left Ventricular Systolic Dysfunction
DrugVericiguat
Merck Sharp & Dohme LLC
Phase 2/3
342
Dublin
2023-05-31
Active, closed
Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer
NCT05740566 Small Cell Lung Cancer (SCLC)
DrugsAmrubicin·Lurbinectedin·Tarlatamab·Topotecan
Amgen
Phase 3
509
Dublin
2023-05-31
Active, closed
Linking In With Advice and Supports for Men Impacted by Metastatic Cancer
NCT05946993 Survivorship, Prostate Cancer, Kidney Cancer, Urothelial Tract/Bladder Cancer, Nos
University College Cork
Not applicable
72
Cork
2023-05-08
Active, closed
An Early Access Study of Ivosidenib in Patients With a Pretreated Locally Advanced or Metastatic Cholangiocarcinoma
NCT05876754 Cholangiocarcinoma
DrugIvosidenib
Servier Affaires Médicales
Phase 3
299
Cork, Dublin
2023-05-03
By invitation
An Open-label Study of XEN1101 in Epilepsy
NCT05718817 Focal Epilepsy, Tonic-Clonic Seizures
DrugAzetukalner
Xenon Pharmaceuticals Inc.
Phase 3
880
Dublin
2023-04-25
Active, closed
Ultimaster Nagomi™ Sirolimus Eluting Coronary Stent System in Complex PCI Patients
NCT05705973 Cardiovascular Disease, Coronary Artery Occlusion, Ischemic Heart Disease
Terumo Europe N.V.
Observational
3,000
Cork, Dublin, Galway
2023-04-25
Active, closed
Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma
NCT05611931 Endometrial Cancer
DrugSelinexor
Karyopharm Therapeutics Inc
Phase 3
257
Dublin, Cork, Galway, Waterford
2023-04-18
Recruiting
First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors
NCT05768139 Breast Cancer, Solid Tumors, Adult
DrugsTersolisib·Imlunestrant·Tamoxifen·Exemestane
Eli Lilly and Company
Phase 1/2
880
Dublin
2023-04-17
Recruiting
CLASSICA: Validating AI in Classifying Cancer in Real-Time Surgery
NCT05793554 Rectum Neoplasm, Rectum Polyp, Rectal Cancer
Mater Misericordiae University Hospital
Observational
600
Dublin
2023-03-31
Active, closed
Real World Data Collection in Subjects Treated With the FARAPULSE Pulsed Field Ablation System
NCT05501873 Atrial Fibrillation
Boston Scientific Corporation
Observational
1,173
Dublin
2023-03-24
Active, closed
Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer
NCT05445778 Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
DrugsMirvetuximab Soravtansine·Bevacizumab
AbbVie
Phase 3
520
Dublin, Cork, Galway, Sligo, Waterford
2023-03-15
Recruiting
Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein
NCT05677971 Alpha1-Antitrypsin Deficiency
DrugFazirsiran
Takeda
Phase 3
160
Dublin
2023-03-06
Active, closed
REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels
NCT05669755 Cardiovascular Disease
DrugsCagrilintide·Semaglutide
Novo Nordisk A/S
Phase 3
7,101
Galway, Dublin
2023-03-01
Active, closed
DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)
NCT05566795 Low-grade Glioma, Rapidly Accelerated Fibrosarcoma (RAF) Altered Glioma, Pediatric Low-grade Glioma
DrugsTovorafenib·Carboplatin
Day One Biopharmaceuticals, Inc.
Phase 3
418
Crumlin
2023-02-27
Active, closed
Safety and Efficacy Study of Viaskin Peanut in Peanut-allergic Children 4-7 Years of Age
NCT05741476 Allergy, Peanut
DBV Technologies
Phase 3
600
Cork, Dublin
2023-02-21
Active, closed
Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD
NCT05711940 Treatment Resistant Depression
DrugPsilocybin
COMPASS Pathways
Phase 3
572
Dublin, Galway
2023-02-14
Active, closed
A Research Study Looking at Long-term Treatment With Mim8 in People With Haemophilia A
NCT05685238 Haemophilia A, Haemophilia A With Inhibitors
Novo Nordisk A/S
Phase 3
451
Dublin
2023-02-13
Recruiting
Dopamine vs. Norepinephrine for Hypotension in Very Preterm Infants With Late-onset Sepsis
NCT05347238 Late-Onset Neonatal Sepsis, Extreme Prematurity, Neonatal Hypotension
DrugsDopamine·Norepinephrine
Mount Sinai Hospital, Canada
Observational
550
Cork, Dublin
2023-02-06
Recruiting
Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial
NCT05327686 Metastatic Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8, Unresectable Renal Cell Carcinoma
DrugsAxitinib·Avelumab·Cabozantinib·Yervoy
NRG Oncology
Phase 2
240
Dublin
2023-02-01
Active, closed
A Trial to See if the Combination of Fianlimab With Cemiplimab Works Better Than Pembrolizumab for Preventing or Delaying Melanoma From Coming Back After it Has Been Removed With Surgery
NCT05608291 Melanoma
DrugsFianlimab·Cemiplimab·Keytruda·Pembrolizumab
Regeneron Pharmaceuticals
Phase 3
1,564
Galway, Cork, Dublin
2023-01-16
Active, closed
ABTECT - Maintenance
NCT05535946 Ulcerative Colitis
DrugObefazimod
Abivax S.A.
Phase 3
1,116
Mullingar, Dublin
2023-01-16
Active, closed
A Study to Assess Effectiveness and Safety of Deucravacitinib Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE)
NCT05617677 Systemic Lupus Erythematosus
DrugDeucravacitinib
Bristol-Myers Squibb
Phase 3
516
Manorhamilton, Cork, Dublin
2023-01-12
Active, closed
First in Human Study of IMGN151 in Recurrent Gynaecological Cancers
NCT05527184 Endometrial Cancer, High Grade Serous Adenocarcinoma of Ovary, Primary Peritoneal Carcinoma, Fallopian Tube Cancer
DrugIMGN151
AbbVie
Phase 1
256
Dublin
2023-01-11
Active, closed
Study to Evaluate the Safety and Efficacy of Tafasitamab Plus Lenalidomide in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (firmMIND)
NCT05429268 Large B-Cell Lymphoma, Diffuse Large B-Cell Lymphoma
DrugsTafasitamab·Lenalidomide
Incyte Corporation
Phase 3
82
Cork, Dublin, Galway
2022-12-23
Recruiting
European Myeloma Network (EMN) Sample Project
NCT06237803 Multiple Myeloma, Smoldering Multiple Myeloma, Plasma Cell Leukemia, Extramedullary Myeloma
European Myeloma Network B.V.
Observational
6,000
Galway
2022-12-21
Recruiting
AI-assisted CT for Risk Stratification in Coronary Artery Disease (ACTION)
NCT07577609 Coronary Artery Disease (CAD), Computed Tomography Angiography, Biomarkers, AI (Artificial Intelligence)
University of Galway
Observational
10,000
Galway
2022-12-21
Recruiting
A Trial of Lu AG13909 in Participants With Congenital Adrenal Hyperplasia
NCT05669950 Congenital Adrenal Hyperplasia
DrugLu AG13909
H. Lundbeck A/S
Phase 1/2
42
Dublin
2022-12-19
Active, closed
A Study Evaluating the Safety and Tolerability of QRL-201 in ALS
NCT05633459 Amyotrophic Lateral Sclerosis
QurAlis Corporation
Phase 1
69
Dublin
2022-12-16
Recruiting
Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects
NCT05232916 Breast Cancer
Greenwich LifeSciences, Inc.
Phase 3
2,250
Dublin
2022-12-16
Recruiting
Interfant-21 Treatment Protocol for Infants Under 1 Year With KMT2A-rearranged ALL or Mixed Phenotype Acute Leukemia
NCT05327894 Acute Lymphoblastic Leukemia, Mixed Phenotype Acute Leukemia
DrugBlinatumomab
Princess Maxima Center for Pediatric Oncology
Phase 3
160
Dublin
2022-12-15
Recruiting
Co-administration of Acetaminophen With Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature Infants
NCT05340582 Patent Ductus Arteriosus After Premature Birth
DrugsIbuprofen·Acetaminophen
Mount Sinai Hospital, Canada
Phase 2
310
Dublin
2022-12-12
Recruiting
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
NCT05633654 Triple Negative Breast Cancer
DrugsXeloda·Sacituzumab Govitecan·Keytruda·Capecitabine
Gilead Sciences
Phase 3
1,514
Dublin, Limerick, Wilton
2022-12-12
Recruiting
Clinical Outcomes From Treatment and Evaluation of Obstructive Sleep Apnoea in Children With Down Syndrome
NCT06030349 Obstructive Sleep Apnea, Down Syndrome, Quality of Life, Behavior
Children's Health Ireland
Observational
200
Dublin
2022-11-28
Active, closed
Dazucorilant in Patients With Amyotrophic Lateral Sclerosis
NCT05407324 Amyotrophic Lateral Sclerosis
Corcept Therapeutics
Phase 2
279
Dublin
2022-11-15
Active, closed
A Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy
NCT05444257 Cystic Fibrosis
DrugVNZ/TEZ/D-IVA
Vertex Pharmaceuticals Incorporated
Phase 3
822
Cork, Dublin, Limerick
2022-11-08
Active, closed
The GORE® VIABAHN® FORTEGRA Venous Stent IVC Study
NCT05409976 Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis
W.L.Gore & Associates
Not applicable
136
Galway
2022-10-25
Recruiting
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
NCT05253651 Colorectal Neoplasms
DrugsTucatinib·Erbitux·Herceptin·Avastin
Seagen, a wholly owned subsidiary of Pfizer
Phase 3
400
Cork, Dublin, Waterford
2022-10-24
Active, closed
A Study to Learn More About How Well Elinzanetant Works and How Safe it is Compared to Placebo for the Treatment of Hot Flashes Caused by Anti-cancer Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer
NCT05587296 Vasomotor Symptoms Caused by Adjuvant Endocrine Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer, Hot Flashes
Bayer
Phase 3
474
Galway, Dublin, Cork, Waterford
2022-10-14
Active, closed
A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer
NCT05514054 Breast Neoplasms
DrugsImlunestrant·Tamoxifen·Exemestane·Anastrozole
Eli Lilly and Company
Phase 3
8,000
Cork, Dublin, Galway, Sligo, Waterford
2022-10-04
Active, closed
APPETITE: Plant Protein and Exercise Solutions for the Prevention of Undernutrition in Older Adults.
NCT05608707 Appetite Loss, Physical Inactivity, Undernutrition, Anorexia of Aging
University College Dublin
Not applicable
180
Dublin
2022-09-22
Recruiting
A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
NCT05519085 Relapsed or Refractory Multiple Myeloma
DrugsMezigdomide·Velcade·Pomalidomide·Bortezomib
Celgene
Phase 3
810
Galway, Cork, Dublin, Limerick
2022-09-20
Recruiting
Stereotactic Ablative Radiotherapy for OligoMetastatic Breast Cancer
NCT05377047 Breast Cancer Stage IV, Oligometastatic Disease
Vastra Gotaland Region
Phase 3
345
Cork, Dublin, Galway
2022-09-19
Active, closed
A Phase III Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Non Small Cell Lung Cancer (NSCLC) Whose Disease Progressed On or After Prior Anti PD (L)1 Therapy And Platinum Based Chemotherapy
NCT05450692 Advanced or Metastatic Non-Small Cell Lung Cancer
DrugsCeralasertib·Durvalumab·Docetaxel
AstraZeneca
Phase 3
594
Cork, Dublin, Limerick
2022-09-15
Active, closed
Post-market Clinical Investigation of the SING IMT System, Model NG SI IMT 3X in Patients With End-stage Age-related Macular Degeneration
NCT04796545 AMD, Age-Related Macular Degeneration
VisionCare, Inc.
Not applicable
68
Dublin
2022-09-13
Recruiting
A Trial of 5 Fraction Prostate SBRT Versus 5 Fraction Prostate and Pelvic Nodal SBRT
NCT05613023 Prostate Cancer
Institute of Cancer Research, United Kingdom
Phase 3
1,128
Cork, Dublin, Limerick
2022-09-09
Recruiting
Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation
NCT05243797 Multiple Myeloma
DrugsTeclistamab·Lenalidomide
European Myeloma Network B.V.
Phase 3
1,594
Cork, Dublin, Galway, Limerick
2022-09-08
Active, closed
An Observational Study to Assess Change in Disease Activity and Adverse Events of Upadacitinib in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Real-World Practice
NCT05494606 Ulcerative Colitis
AbbVie
Observational
785
Abbotstown, Elm Park, Galway
2022-08-15
Active, closed
Safety, Tolerability, Pharmacodynamic, Efficacy, and Pharmacokinetic Study of DYNE-251 in Participants With Duchenne Muscular Dystrophy Amenable to Exon 51 Skipping
NCT05524883 Duchenne Muscular Dystrophy (DMD)
DrugZeleciment Rostudirsen
Dyne Therapeutics
Phase 1/2
86
Dublin
2022-08-12
Active, closed
A Research Study to Compare Somapacitan Once a Week With Norditropin® Once a Day in Children Who Need Help to Grow
NCT05330325 SGA, Turner Syndrome, Noonan Syndrome, ISS
DrugsNorditropin·Somapacitan
Novo Nordisk A/S
Phase 3
412
Cork, Dublin
2022-08-10
Recruiting
Personalized Mechanical Ventilation Guided by UltraSound in Patients With Acute Respiratory Distress Syndrome
NCT05492344 ARDS, Human, Lung Ultrasound, Mechanical Ventilation
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Not applicable
538
Galway
2022-08-09
Active, closed
Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thrombus Removal to Yield Benefit in Subacute and Chronic Iliofemoral DVT
NCT04858776 Iliofemoral; Thrombosis
Mercator MedSystems, Inc.
Phase 2
60
Galway
2022-08-08
Active, closed
A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)
NCT05458297 Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Follicular Lymphoma, Richter Transformation Lymphoma
DrugsZilovertamab vedotin·Nemtabrutinib
Merck Sharp & Dohme LLC
Phase 2
189
Dublin
2022-07-21
Active, closed
Clinical Study of Fianlimab in Combination With Cemiplimab Versus Pembrolizumab in Adolescent and Adult Patients With Previously Untreated Unresectable Locally Advanced or Metastatic Melanoma
NCT05352672 Melanoma
DrugsFianlimab·Cemiplimab·Keytruda·Pembrolizumab
Regeneron Pharmaceuticals
Phase 3
1,546
Galway, Cork, Dublin
2022-07-14
Recruiting
Effect of Probiotic Limosilactobacillus Reuteri (L. Reuteri) on Crying Time in Infants With Colic
NCT05512234 Colic, Infantile
BioGaia AB
Not applicable
102
Cork
2022-07-13
Active, closed
Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events
NCT05360446 Coronary Artery Disease
DrugInclisiran sodium
Novartis Pharmaceuticals
Phase 3
609
Dublin, Galway
2022-07-08
Recruiting
30% or 60% Oxygen at Birth to Improve Neurodevelopmental Outcomes in Very Low Birthweight Infants
NCT03825835 Premature Infant, Respiratory Distress Syndrome in Premature Infant, Neurodevelopmental Outcome
University of Alberta
Not applicable
1,200
Cork
2022-06-27
Active, closed
(Summit) A Study to Evaluate the Efficacy and Safety of CGT9486 Versus Placebo in Patients With Indolent or Smoldering Systemic Mastocytosis
NCT05186753 SSM, Mastocytosis, Indolent, Mastocytosis, Systemic, Mastocytosis
DrugBezuclastinib
Cogent Biosciences, Inc.
Phase 2
237
Cork, Dublin
2022-06-27
Active, closed
Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
NCT04975997 Multiple Myeloma
DrugsIberdomide·Bortezomib·Daratumumab·Dexamethasone
Celgene
Phase 3
939
Cork, Dublin, Galway
2022-06-23
Recruiting
Semaglutide's Efficacy in Achieving Weight Loss for Those With HIV
NCT04174755 Obesity, HIV-1-infection
DrugSemaglutide Product
University College Dublin
Not applicable
80
Dublin
2022-06-22
Active, closed
ProVee Urethral Expander System IDE Study (ProVIDE)
NCT05186740 BPH With Symptomatic Lower Urinary Tract Symptoms
ProVerum Medical
Not applicable
221
Dublin
2022-06-09
Active, closed
Evolut™ EXPAND TAVR II Pivotal Trial
NCT05149755 Moderate Aortic Valve Stenosis
Medtronic Cardiovascular
Not applicable
650
Galway
2022-04-27
Recruiting
ADT +/- Darolutamide in de Novo Metastatic Prostate Cancer Patients With Vulnerable Functional Ability (PEACE6-Vulnerable)
NCT04916613 Prostate Cancer Metastatic
DrugDarolutamide
UNICANCER
Phase 3
300
Dublin, Limerick
2022-04-19
Recruiting
Brentuximab Vedotin in Early Stage Hodgkin Lymphoma
NCT04685616 Hodgkin Lymphoma
DrugsVinblastine·Filgrastim·Pegfilgrastim·Bleomycin
University College, London
Phase 3
1,042
Dublin, Galway
2022-04-14
Recruiting
Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer
NCT05061550 Non-small Cell Lung Cancer
DrugsAZD0171·Pemetrexed/Cisplatin·Pemetrexed/Carboplatin·Monalizumab
AstraZeneca
Phase 2
630
Dublin, Galway
2022-04-14
Active, closed
Isa-RVD Study in Patients With Newly Diagnosed Multiple Myeloma
NCT05123131 Multiple Myeloma
DrugsIsatuximab·Bortezomib·Lenalidomide·Dexamethasone
Cancer Trials Ireland
Phase 2
54
Dublin, Waterford
2022-04-01
Active, closed
Pembrolizumab/Vibostolimab (MK-7684A) or Atezolizumab in Combination With Chemotherapy in First Line Treatment of Extensive-Stage Small Cell Lung Cancer (MK-7684A-008/KEYVIBE-008)
NCT05224141 Small Cell Lung Carcinoma
DrugsPembrolizumab/Vibostolimab·Tecentriq·Paraplatin·Etoposide
Merck Sharp & Dohme LLC
Phase 3
460
Dublin
2022-03-24
Active, closed
A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)
NCT05239728 Carcinoma, Renal Cell
DrugsBelzutifan·Keytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
1,800
Dublin, Cork
2022-03-15
Active, closed
A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma
NCT05100862 Relapsed/Refractory Follicular Lymphoma, Marginal Zone Lymphoma
DrugsRuxience·Truxima·Zanubrutinib·Obinutuzumab
BeOne Medicines
Phase 3
799
Dublin, Waterford
2022-03-10
Active, closed
A Phase 3 Study to Examine the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder.
NCT05064878 CDKL5 Deficiency Disorder, Generalized Tonic Clonic Seizure, Epileptic Spasm, Refractory Seizures
DrugFintepla
Zogenix, Inc.
Phase 3
87
Dublin
2022-03-08
Recruiting
Follow-up Study to Monitor the Efficacy and Safety of the Occlutech® mVSD Cases
NCT05329350 Muscular Ventricular Septal Defect
Occlutech International AB
Observational
50
Dublin
2022-03-03
Recruiting
Characterization of the Blood-Brain Barrier in High-Grade Glioma Through Immunohistochemical, Transcriptional, Fluorescein and Radiological Analyses
NCT07731555 Glioblastoma
Patrick Morris
Not applicable
100
Beaumont
2022-03-01
Active, closed
Direct Measurement of Microstructure of Ingestive Behaviour After Initiation of GLP-1 Receptor Agonist Treatment at Maximum Dose (DIGRAT)
NCT07457424 Metabolic Disease, Obesity & Overweight
DrugSemaglutide
University College Dublin
Observational
140
Dublin
2022-02-17
Recruiting
Awareness Detection and Communication in Disorders of Consciousness
NCT03827187 Disorder of Consciousness, Paralysis, Motor Neuron Disease, Stroke
University of Ulster
Not applicable
30
Dublin
2022-02-08
Active, closed
Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma (MK-3475-C93/KEYNOTE-C93/GOG-3064/ENGOT-en15)
NCT05173987 Endometrial Neoplasms
DrugsTaxotere·Paraplatin·Taxol·Docetaxel
Merck Sharp & Dohme LLC
Phase 3
280
Cork, Dublin
2022-02-03
Active, closed
Study Assessing Long-term Safety and Efficacy of Alpelisib in Patients With PIK3CA-Related Overgrowth Spectrum (PROS) Who Previously Participated in Study CBYL719F12002 (EPIK-P1)
NCT04980833 PIK3CA-related Overgrowth Spectrum (PROS)
DrugAlpelisib
Novartis Pharmaceuticals
Phase 2
41
Dublin
2022-01-27
Recruiting
Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers
NCT05098132 Advanced Solid Tumor, Non Small Cell Lung Cancer, Untreated Advanced NSCLC, 1st Line NSCLC
DrugsPembrolizumab KEYTRUDA·Pemetrexed·Carboplatin
Synthekine
Phase 1/2
364
Dublin, Galway
2022-01-25
Active, closed
Post Marketing Clinical Follow Up of the BioProtect Balloon Implant System
NCT05354440 Prostate Cancer
BioProtect
Observational
80
Dublin
2022-01-01
Active, closed
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)
NCT05269394 Alzheimers Disease, Dementia, Alzheimers Disease, Familial
DrugsE2814·Lecanemab
Washington University School of Medicine
Phase 2/3
197
Dublin
2021-12-22
Active, closed
Effectiveness of the SpaceOAR Vue System in Subjects With Prostate Cancer
NCT04905069 Prostate Cancer
Boston Scientific Corporation
Not applicable
500
Cork
2021-12-21
Active, closed
Study to Assess the Efficacy and Safety of Alpelisib Plus Fulvestrant in Participants With HR-positive (HR+), HER2-negative, Advanced Breast Cancer After Treatment With a CDK4/6 Inhibitor and an Aromatase Inhibitor.
NCT05038735 Breast Cancer
DrugsAlpelisib·Fulvestrant
Novartis Pharmaceuticals
Phase 3
210
Dublin
2021-12-17
Active, closed
Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS) (REMODEL-1)
NCT05147220 Relapsing Multiple Sclerosis
DrugsTeriflunomide·Remibrutinib
Novartis Pharmaceuticals
Phase 3
1,000
Dublin
2021-12-16
Active, closed
Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Adult Patients With Uncontrolled Moderate to Severe Asthma
NCT05097287 Asthma
DrugDupilumab
Sanofi
Phase 4
1,339
Cork, Dublin
2021-12-16
Active, closed
Pembrolizumab/Placebo Plus Paclitaxel With or Without Bevacizumab for Platinum-resistant Recurrent Ovarian Cancer (MK-3475-B96/KEYNOTE-B96/ENGOT-ov65).
NCT05116189 Ovarian Cancer, Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms
DrugsZirabev·Taxotere·Avastin·Docetaxel
Merck Sharp & Dohme LLC
Phase 3
643
Dublin
2021-12-13
Active, closed
CPD-DARA in Patients With Relapsed/Refractory Multiple Myeloma.
NCT04667663 Multiple Myeloma
DrugsPomalidomide·Daratumumab·Dexamethasone·Cyclophosphamide
Cancer Trials Ireland
Phase 1
16
Cork, Dublin, Galway
2021-12-08
Active, closed
A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers
NCT05152147 Gastric Neoplasms, Gastroesophageal Adenocarcinoma, Esophageal Adenocarcinoma
DrugsZanidatamab·Herceptin·Trastuzumab·Adrucil
Jazz Pharmaceuticals
Phase 3
920
Dublin
2021-12-02
Recruiting
(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis
NCT04910685 Indolent Systemic Mastocytosis, Smoldering Systemic Mastocytosis
Blueprint Medicines Corporation
Phase 2/3
534
Cork
2021-11-30
Active, closed
A Phase 3 Study to Evaluate the Safety and Efficacy of Efgartigimod PH20 Subcutaneous in Adult Patients With Primary Immune Thrombocytopenia
NCT04812925 Primary Immune Thrombocytopenia
DrugEfgartigimod PH20
argenx
Phase 3
173
Dublin
2021-11-17
Recruiting
The PIONEER-IV Study is Comparing Clinical Outcomes Between Angiography-derived Physiology Guidance to Usual Care in an All-comers PCI Population With Unrestrictive Use of the HT Supreme Sirolimus-eluting Stent
NCT04923191 Coronary Artery Disease
National University of Ireland, Galway, Ireland
Not applicable
2,540
Galway
2021-11-12
Recruiting
Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thrombus Removal to Yield Benefit in Acute Femoropopliteal DVT
NCT04862468 Thrombosis, Deep Vein, Iliofemoral; Thrombosis
Mercator MedSystems, Inc.
Phase 2
80
Galway
2021-10-29
Active, closed
Open-Label Safety Study of Acoramidis (AG10) in Symptomatic ATTR Participants
NCT04988386 Amyloid Cardiomyopathy, Transthyretin-Related
DrugAcoramidis
Eidos Therapeutics, a BridgeBio company
Phase 3
389
Dublin
2021-10-27
Active, closed
Australasian Resuscitation In Sepsis Evaluation: FLUid or Vasopressors In Emergency Department Sepsis
NCT04569942 Shock, Septic
DrugVasopressor
Australian and New Zealand Intensive Care Research Centre
Phase 3
1,000
Elm Park
2021-10-26
Active, closed
SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
NCT05198674 Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases
Medtronic Vascular
Not applicable
1,899
Dublin
2021-10-20
Active, closed
A Study Evaluating the Efficacy and Safety of Afimetoran Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE)
NCT04895696 Systemic Lupus Erythematosus
Beeline Medicines Corporation
Phase 2
248
Dublin, Galway, Manorhamilton
2021-10-11
Recruiting
Precision Diagnosis and Care for Families With Pulmonary Fibrosis in Ireland
NCT06702228 Connective Tissue Diseases, Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis, Familial Idiopathic Pulmonary Fibrosis
Royal College of Surgeons, Ireland
Observational
300
Dublin
2021-09-28
Active, closed
Study of INBRX-109 in Conventional Chondrosarcoma
NCT04950075 Conventional Chondrosarcoma
DrugINBRX-109
Inhibrx Biosciences, Inc
Phase 2
206
Dublin
2021-09-23
Active, closed
A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)
NCT04965493 Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
DrugsRiabni·Ruxience·Truxima·Pirtobrutinib
Loxo Oncology, Inc.
Phase 3
600
Dublin, Waterford
2021-09-20
Recruiting
A Beta-only IL-2 ImmunoTherapY Study
NCT05086692 Advanced Solid Tumor, Unresectable Solid Tumor, Clear Cell Renal Cell Carcinoma, Triple Negative Breast Cancer
DrugsKeytruda·Pembrolizumab
Medicenna Therapeutics, Inc.
Phase 1/2
115
Dublin
2021-08-27
Active, closed
A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)
NCT04961996 Early Breast Cancer
DrugGiredestrant
Hoffmann-La Roche
Phase 3
4,170
Cork, Dublin, Galway, Limerick, Waterford
2021-08-27
Active, closed
A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Cilta-cel, a CAR-T Therapy Directed Against BCMA Versus VRd Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom ASCT is Not Planned as Initial Therapy
NCT04923893 Multiple Myeloma
DrugsCilta-cel·Bortezomib·Lenalidomide·Fludarabine
Janssen Research & Development, LLC
Phase 3
743
Dublin
2021-08-19
Active, closed
Ultrasound-facilitated, Catheter-directed, Thrombolysis in Intermediate-high Risk Pulmonary Embolism
NCT04790370 Pulmonary Embolism
DrugsLMWH·Heparin
Boston Scientific Corporation
Phase 4
544
Dublin, Galway
2021-08-02
Active, closed
A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease-modifying Anti-rheumatic Drugs
NCT04908202 Psoriatic Arthritis
DrugDeucravacitinib
Bristol-Myers Squibb
Phase 3
670
Manorhamilton, Dublin, Galway
2021-07-13
Active, closed
Long-Term Observational Study on Effectiveness and Safety of Lecigon in Patients With Advanced Parkinson's Disease
NCT05043103 Advanced Parkinson Disease
Britannia Pharmaceuticals Ltd.
Observational
312
Dublin
2021-07-06
Active, closed
Efficacy and Safety Comparison of Niraparib to Placebo in Participants With Human Epidermal Growth Factor 2 Negative (HER2-) Breast Cancer Susceptibility Gene Mutation (BRCAmut) or Triple-Negative Breast Cancer (TNBC) With Molecular Disease
NCT04915755 Neoplasms, Breast
DrugNiraparib
GlaxoSmithKline
Phase 3
40
Dublin
2021-06-28
Active, closed
Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)
NCT04793958 Advanced Colorectal Cancer, Metastatic Colorectal Cancer
DrugsAdagrasib·MFOLFOX6·Erbitux·Folfiri
Mirati Therapeutics Inc.
Phase 3
461
Dublin
2021-06-24
Active, closed
A Study of T-DXd in Participants With or Without Brain Metastasis Who Have Previously Treated Advanced or Metastatic HER2 Positive Breast Cancer
NCT04739761 Breast Cancer
DrugTrastuzumab deruxtecan
AstraZeneca
Phase 3
506
Cork, Dublin
2021-06-22
Active, closed
Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)
NCT04895358 Breast Neoplasms
DrugsLiposomal doxorubicin·Abraxane·Xeloda·Taxol
Merck Sharp & Dohme LLC
Phase 3
342
Dublin
2021-06-18
Active, closed
FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS)
NCT04768972 Amyotrophic Lateral Sclerosis
Ionis Pharmaceuticals, Inc.
Phase 3
89
Dublin
2021-06-14
Recruiting
Trial-Ready Cohort-Down Syndrome (TRC-DS)
NCT04165109 Down Syndrome, Alzheimer Disease, Dementia
University of Southern California
Observational
550
Dublin
2021-06-07
Active, closed
A Study of Subcutaneous Nivolumab Versus Intravenous Nivolumab in Participants With Previously Treated Clear Cell Renal Cell Carcinoma That is Advanced or Has Spread
NCT04810078 Clear Cell Renal Cell Carcinoma
DrugsNivolumab and rHuPH20·Opdivo·Nivolumab
Bristol-Myers Squibb
Phase 3
681
Tallaght
2021-05-21
Active, closed
Trastuzumab Deruxtecan for Subjects With HER2-Positive Gastric Cancer or Gastro-Esophageal Junction Adenocarcinoma After Progression on or After a Trastuzumab-Containing Regimen (DESTINY-Gastric04)
NCT04704934 Gastric Cancer, Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
DrugsRamucirumab·Trastuzumab deruxtecan·Paclitaxel
Daiichi Sankyo
Phase 3
490
Cork, Dublin
2021-05-21
Active, closed
Clinical Trial of Inhaled Molgramostim Nebulizer Solution in Autoimmune Pulmonary Alveolar Proteinosis (aPAP)
NCT04544293 Autoimmune Pulmonary Alveolar Proteinosis
DrugMolgramostim
Savara Inc.
Phase 3
164
Dublin
2021-05-19
Active, closed
Tafasitamab + Lenalidomide + R-CHOP Versus R-CHOP in Newly Diagnosed High-intermediate and High Risk DLBCL Patients
NCT04824092 Diffuse Large B-cell Lymphoma
DrugsTafasitamab·Vincristine·Doxorubicin·Prednisone
Incyte Corporation
Phase 3
899
Dublin, Limerick
2021-05-11
Active, closed
A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Participants With High-risk Muscle-invasive Bladder Cancer (MIBC) Who Are ctDNA Positive Following Cystectomy
NCT04660344 Muscle-invasive Bladder Cancer
DrugsTecentriq·Atezolizumab
Hoffmann-La Roche
Phase 3
761
Cork, Dublin
2021-05-03
Recruiting
Vitrectomy, Subretinal Tissue Plasminogen Activator (TPA) and Intravitreal Gas for Submacular Haemorrhage Secondary to Exudative (Wet) Age-related Macular Degeneration (TIGER).
NCT04663750 Eye Diseases, Macular Degeneration, Wet, Sub-Macular Hemorrhage
King's College Hospital NHS Trust
Phase 3
210
Waterford
2021-04-16
Active, closed
A Phase 3 Study to Assess Efficacy and Safety of Tafasitamab Plus Lenalidomide and Rituximab Compared to Placebo Plus Lenalidomide and Rituximab in Patients With Relapsed/Refractory (R/R) Follicular Lymphoma or Marginal Zone Lymphoma.
NCT04680052 Follicular Lymphoma, Marginal Zone Lymphoma
DrugsTafasitamab·Lenalidomide·Rituximab
Incyte Corporation
Phase 3
654
Dublin, Galway
2021-04-15
Active, closed
A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)
NCT04736706 Carcinoma, Renal Cell
DrugsPembrolizumab/Quavonlimab·Belzutifan·Lenvatinib·Keytruda
Merck Sharp & Dohme LLC
Phase 3
1,688
Dublin
2021-04-14
Recruiting
Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)
NCT04728893 Hematologic Malignancies, Waldenstroms Macroglobulinaemia, Non-Hodgkins Lymphoma, Chronic Lymphocytic Leukaemia
DrugNemtabrutinib
Merck Sharp & Dohme LLC
Phase 2
490
Dublin, Limerick
2021-04-05
Recruiting
FEmale Metabolic Risk and Androgens: an Irish Longitudinal (FEMAIL) Study
NCT04912648 Hyperandrogenism, Metabolic Disease, Sex Hormones Adverse Reaction
Royal College of Surgeons, Ireland
Observational
500
Dublin
2021-04-01
Recruiting
Medication Following Bariatric Surgery for Type 2 Diabetes Mellitus
NCT04432025 Obesity, Type 2 Diabetes
Imperial College London
Not applicable
150
Dublin
2021-04-01
Active, closed
Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)
NCT04822181 Non-alcoholic Steatohepatitis
DrugSemaglutide
Novo Nordisk A/S
Phase 3
1,205
Dublin
2021-04-01
Recruiting
BoStOn SCientific Rhythm MAnagemenT REgiStry
NCT04823663 Cardiac Disease
Boston Scientific Corporation
Observational
12,500
Dublin
2021-03-31
Active, closed
Study of LOXO-305 (Pirtobrutinib) Versus Investigator's Choice (Idelalisib Plus Rituximab or Bendamustine Plus Rituximab) in Patients With Previously Treated Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
NCT04666038 Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
DrugsIdelalisib·Truxima·Pirtobrutinib·Bendamustine
Loxo Oncology, Inc.
Phase 3
238
Dublin
2021-03-09
Active, closed
Ibrutinib Monotherapy Versus Fixed-duration Venetoclax Plus Obinutuzumab Versus Fixed-duration Ibrutinib Plus Venetoclax in Patients With Previously Untreated Chronic Lymphocytic Leukaemia (CLL)
NCT04608318 Chronic Lymphoid Leukemia
DrugsVenclyxto·Ibrutinib·Obinutuzumab·Venetoclax
German CLL Study Group
Phase 3
897
Cork, Dublin, Galway, Limerick, Waterford
2021-03-01
Recruiting
Axillary Management in Breast Cancer Patients With Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy
NCT04109079 Breast Cancer, Sentinel Lymph Node, Neoplasm, Breast
University Hospitals of Derby and Burton NHS Foundation Trust
Not applicable
1,900
Dublin, Galway
2021-02-26
Active, closed
An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions
NCT04717414 Myeloproliferative Disorders, Myelofibrosis, Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis
DrugLuspatercept
Celgene
Phase 3
313
Cork, Dublin
2021-02-25
Active, closed
A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)
NCT04586231 Carcinoma, Renal Cell
DrugsBelzutifan·Cabozantinib·Lenvatinib
Merck Sharp & Dohme LLC
Phase 3
747
Dublin
2021-02-25
Active, closed
Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
NCT04685135 Metastatic Non Small Cell Lung Cancer, Advanced Non Small Cell Lung Cancer
DrugsAdagrasib·Taxotere·Docetaxel
Mirati Therapeutics Inc.
Phase 3
453
Tallaght, Dublin, Galway, Limerick
2021-02-23
Active, closed
Long-term Safety and Efficacy of Efanesoctocog Alfa (BIVV001) in Previously Treated Patients With Hemophilia A
NCT04644575 Hemophilia A
DrugEfanesoctocog alfa
Bioverativ, a Sanofi company
Phase 3
261
Dublin
2021-02-23
Recruiting
An Observational Post-marketing Study Using Commercially Approved Biosense Webster (BWI) Medical Devices for the Treatment of Participants With Cardiac Arrhythmias
NCT04750798 Arrhythmias, Cardiac
Biosense Webster, Inc.
Observational
8,000
Dublin
2021-02-22
Recruiting
Statins for Venous Event Reduction in Patients With Venous Thromboembolism
NCT04319627 Venous Thromboembolism, Blood Clot, Post Thrombotic Syndrome
DrugsRosuvastatin Calcium·Rosuvastatin
Ottawa Hospital Research Institute
Phase 3
2,700
Dublin
2021-02-10
Recruiting
iCorMicA - Stratified Medicine in Angina
NCT04674449 Microvascular Angina, Angina, Stable, Ischemia With No Obstructive Coronary Arteries (INOCA), Coronary Microvascular Dysfunction (CMD)
NHS Greater Glasgow and Clyde
Not applicable
1,500
Cork, Dublin
2020-12-30
Recruiting
'SOURCE - LUNG' Stereotactic Ablative Radiation Therapy Of UltRaCEntral LUNG Tumours (SOURCE Lung)
NCT04375904 NSCLC/Oligometastatic Cancer (Single Lung Lesion)
Cancer Trials Ireland
Phase 2
68
Dublin
2020-12-22
Active, closed
A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)
NCT04622319 HER2-Positive Primary Breast Cancer, Residual Invasive Breast Cancer
DrugsTrastuzumab emtansine·Trastuzumab deruxtecan
Daiichi Sankyo
Phase 3
1,600
Dublin, Cork, Limerick
2020-12-04
Active, closed
A Study of Inebilizumab Efficacy and Safety in IgG4- Related Disease
NCT04540497 IgG4 Related Disease
DrugInebilizumab
Amgen
Phase 3
135
Cork
2020-12-04
Recruiting
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
NCT04613596 Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer
DrugsAdagrasib·Pembrolizumab
Mirati Therapeutics Inc.
Phase 2/3
626
Cork, Dublin, Galway, Limerick, Waterford
2020-12-02
Recruiting
Chemoradiotherapy Followed by Planned Surgery or by Surveillance and Surgery Only When Needed for Oesophageal Cancer
NCT04460352 Esophageal Squamous Cell Carcinoma
DrugCarboplatin/Paclitaxel
Karolinska University Hospital
Phase 3
1,020
Dublin
2020-11-27
Active, closed
Evaluation of Safety and Performance of the Omega™ LAA (Left Atrial Appendage) Occluder and Omega™ Delivery System in Patients With Non-Valvular Atrial Fibrillation and High Bleeding Risk
NCT04829929 Non-Valvular Atrial Fibrillation
Eclipse Medical Ltd.
Not applicable
200
Dublin
2020-11-17
Recruiting
ErythroPOietin Alfa to Prevent Mortality and Reduce Severe Disability in Critically Ill TRAUMA Patients
NCT04588311 Trauma, Traumatic Injury, Traumatic Brain Injury, Wounds and Injuries
DrugEpoetin Alfa
Australian and New Zealand Intensive Care Research Centre
Phase 3
2,500
Beaumont, Cork, Dublin
2020-11-09
Active, closed
Sacituzumab Govitecan in Primary HER2-negative Breast Cancer
NCT04595565 HER2-negative Breast Cancer, Triple Negative Breast Cancer
DrugsXeloda·Sacituzumab Govitecan·Paraplatin·Capecitabine
GBG Forschungs GmbH
Phase 3
1,332
Cork, Dublin, Limerick, Waterford
2020-10-28
Active, closed
A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors
NCT04432584 Paroxysmal Nocturnal Hemoglobinuria
DrugsCrovalimab·Eculizumab
Hoffmann-La Roche
Phase 3
190
Dublin
2020-09-30
Active, closed
Multivessel TALENT
NCT04390672 Coronary Artery Disease, Myocardial Ischemia, Coronary Disease, Heart Diseases
National University of Ireland, Galway, Ireland
Not applicable
1,550
Galway
2020-09-22
Recruiting
FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma
NCT04625907 Rhabdomyosarcoma
DrugsActinomycin-D·Dactinomycin·Ifosfamide·Vinorelbine
University of Birmingham
Phase 1/2
1,672
Crumlin
2020-09-17
Active, closed
Using FDG-PET/CT to Assess Response of Bone-Dominant Metastatic Breast Cancer, FEATURE Study
NCT04316117 Anatomic Stage IV Breast Cancer AJCC v8, Hormone Receptor Positive Breast Carcinoma, Metastatic Breast Carcinoma, Prognostic Stage IV Breast Cancer AJCC v8
ECOG-ACRIN Cancer Research Group
Phase 2
138
Cork
2020-09-15
Active, closed
Real World Clinical Outcomes With Novel Modulator Therapy Combinations in People With CF (RECOVER)
NCT04602468 Cystic Fibrosis, Cystic Fibrosis Liver Disease, Cystic Fibrosis in Children, Adherence, Medication
DrugElexacaftor/Tezacaftor/Ivacaftor
Royal College of Surgeons, Ireland
Phase 4
206
Dublin, Limerick, Tallaght
2020-09-03
Recruiting
BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours
NCT04421820 Colorectal Cancer, Pancreatic Cancer, Gastric Cancers, Cholangiocarcinoma
DrugsBOLD-100·Oxaliplatin
Bold Therapeutics, Inc.
Phase 1/2
220
Dublin
2020-08-28
Active, closed
STABILITY 2: Anterior Cruciate Ligament Reconstruction +/- Lateral Tenodesis With Patellar vs Quad Tendon
NCT03935750 Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Reconstruction, Joint Instability
University of Pittsburgh
Not applicable
1,272
Dublin
2020-07-28
Active, closed
A Study to Compare Safety and Efficacy of High Doses of Eteplirsen in Participants With Duchenne Muscular Dystrophy (DMD) (MIS51ON)
NCT03992430 Muscular Dystrophy, Duchenne
DrugEteplirsen
Sarepta Therapeutics, Inc.
Phase 3
160
Dublin
2020-07-13
Recruiting
A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia
NCT04307576 Leukemia, Acute Lymphoblastic
DrugsInotuzumab Ozogamicin·Imatinib·Blinatumomab
Mats Heyman
Phase 3
6,430
Dublin
2020-07-13
Active, closed
Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma
NCT04270409 Plasma Cell Myeloma
DrugsMontelukast·Diphenhydramine·Acetaminophen·Isatuximab
Sanofi
Phase 3
337
Dublin
2020-06-16
Recruiting
Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body
NCT04142437 Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene Fusion
DrugLarotrectinib
Bayer
Observational
150
Many Locations
2020-04-03
Active, closed
Darolutamide Augments Standard Therapy for Localised Very High-Risk Cancer of the Prostate
NCT04136353 Prostate Cancer
DrugDarolutamide
University of Sydney
Phase 3
1,100
Rathgar, Cork, Dublin, Galway
2020-03-31
Recruiting
TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention
NCT04294927 BRCA1 Gene Mutation, BRCA2 Gene Mutation, RAD51C Gene Mutation, RAD51D Gene Mutation
University Medical Center Nijmegen
Not applicable
3,000
Cork
2020-03-01
Active, closed
Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors
NCT04262466 Select Advanced Solid Tumors
DrugBrenetafusp
Immunocore Ltd
Phase 1/2
410
Dublin
2020-02-25
Active, closed
A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension
NCT04175600 Hypertension, Pulmonary
DrugSelexipag
Actelion
Phase 3
138
Dublin
2020-01-16
Active, closed
Paediatric Sjögren Syndrome Cohort Study and Repository (PaedSSCoRe)
NCT04762108 Sjogren's Syndrome Childhood-onset
University College, London
Observational
300
Dublin
2020-01-11
Active, closed
PROACTIVE-HF IDE Trial Heart Failure NYHA Class III
NCT04089059 Heart Failure NYHA Class III
Endotronix, Inc.
Not applicable
738
Galway
2020-01-10
Active, closed
Primary Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
NCT03772028 Ovarian Cancer
DrugCisplatin
The Netherlands Cancer Institute
Phase 3
538
Dublin
2020-01-01
Active, closed
A Study of Gilteritinib Versus Midostaurin in Combination With Induction and Consolidation Therapy Followed by One-year Maintenance in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndromes With Excess Blasts-2 With FLT3 Mutations Eligible for Intensive Chemotherapy
NCT04027309 Acute Myeloid Leukemia, Myelodysplastic Syndrome With Excess Blasts-2
DrugsMidostaurin·Gilteritinib
Stichting Hemato-Oncologie voor Volwassenen Nederland
Phase 3
777
Cork, Dublin, Galway, Limerick
2019-12-20
Recruiting
Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma
NCT03860883 Cutaneous Melanoma, Stage II
Melanoma and Skin Cancer Trials Limited
Not applicable
2,998
Cork, Dublin
2019-12-17
Recruiting
Dundrum Forensic Redevelopment Evaluation Study: D-FOREST Study.
NCT05074732 Schizophrenia, Forensic Psychiatry, Outcome Measure, Violence
Health Service Executive, Ireland
Observational
350
Dublin
2019-12-01
Active, closed
HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
NCT04153149 Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
DrugVutrisiran
Alnylam Pharmaceuticals
Phase 3
655
Dublin
2019-11-26
Active, closed
Clinical Evaluation of a Point of Care (POC) Assay to Identify Phenotypes in the Acute Respiratory Distress Syndrome
NCT04009330 Acute Respiratory Distress Syndrome (ARDS)
Queen's University, Belfast
Observational
480
Dublin
2019-11-22
Active, closed
First in Human Clinical Investigation of the FIRE1 System in Heart Failure Patients (FUTURE-HF)
NCT04203576 Heart Failure
Foundry Innovation & Research 1, Limited (FIRE1)
Not applicable
50
Galway
2019-11-22
Active, closed
Efficacy, Safety and Tolerability of Nangibotide in Patients With Septic Shock
NCT04055909 Shock, Septic
Inotrem
Phase 2
355
Dublin, Galway
2019-11-13
Active, closed
A Study of Neoadjuvant Chemotherapy Plus Nivolumab Versus Neoadjuvant Chemotherapy Plus Placebo, Followed by Surgical Removal and Adjuvant Treatment With Nivolumab or Placebo for Participants With Surgically Removable Early Stage Non-small Cell Lung Cancer
NCT04025879 Carcinoma, Non-Small-Cell Lung
DrugsOpdivo·Pemetrexed·Docetaxel·Nivolumab
Bristol-Myers Squibb
Phase 3
461
Dublin
2019-11-05
Active, closed
Stereotactic Ablative Radiotherapy for Comprehensive Treatment of Oligometastatic (1-3 Metastases) Cancer
NCT03862911 Metastatic Tumors
British Columbia Cancer Agency
Not applicable
330
Rathgar, Dublin, Cork
2019-11-01
Recruiting
Treatment Study for Children and Adolescents With Acute Promyelocytic Leukemia
NCT04793919 Acute Promyelocytic Leukemia
DrugsMylotarg·All-trans retinoic acid·Arsenic Trioxide·ATRA
Associazione Italiana Ematologia Oncologia Pediatrica
Phase 2
89
Dublin
2019-10-09
Active, closed
A Study of Guselkumab in Participants With Moderately to Severely Active Ulcerative Colitis
NCT04033445 Ulcerative Colitis
DrugGuselkumab
Janssen Research & Development, LLC
Phase 2/3
1,064
Dublin, Galway
2019-09-26
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Priya Life Science (2026). Clinical trial register: studies with an Irish investigative site. Derived from ClinicalTrials.gov, U.S. National Library of Medicine. Retrieved 4 October 2026. https://priyalifescience.com/clinical-trials-ireland

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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Ireland and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 597 studies in total at the last sync on 04 Oct 2026, 03:15 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

How many clinical trials are recruiting in Ireland?

304 of the 597 studies in this register are recruiting new participants as of the 04 Oct 2026, 03:15 UTC sync. A further 28 have not yet opened recruitment, 244 are active but closed to new participants, and 21 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Summary by phase

Studies by phase, 597 studies
PhaseStudiesRecruitingShare
Phase 32379239.7%
Not applicable1407523.5%
Observational1047217.4%
Phase 257269.5%
Phase 1/224214%
Phase 2/31572.5%
Phase 11071.7%
Phase 41041.7%

Most active sponsors

Lead sponsors with the most studies
Lead sponsorStudiesRecruiting
Merck Sharp & Dohme LLC3519
Royal College of Surgeons, Ireland2922
University College Dublin2111
AbbVie202
University College Cork1811
Bristol-Myers Squibb166
Cancer Trials Ireland137
AstraZeneca106
University of Limerick106
Eli Lilly and Company97

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Browse trials by condition

Breast Cancer (23) Prostate Cancer (14) Cancer (11) Ulcerative Colitis (11) Multiple Myeloma (10) Crohn's Disease (9) Ovarian Cancer (8) Chronic Lymphocytic Leukemia (7) Non-small Cell Lung Cancer (7) Fallopian Tube Cancer (6) Vascular Diseases (6) Hypertension (6) Cardiovascular Diseases (6) Idiopathic Pulmonary Fibrosis (5) Non-Small Cell Lung Cancer (5)
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Browse trials by site location

Dublin (479) Cork (168) Galway (123) Limerick (56) Waterford (52) Beaumont (13) Sligo (12)
Listing here is informational and not medical advice; eligibility is determined by each study team. Patients should discuss participation with their clinician. For trials across the wider EU, see the EU Clinical Trials Tracker.