Clinical Trials in Ireland 2026 — Live Tracker

Chronic Kidney Disease, Proteinuria, Blood Pressure Control, Congenital Anomalies of the Kidneys and Urinary Tract
St. James's Hospital, Ireland · started 2026-01-14

📍 Dublin

NCT07561957 on ClinicalTrials.gov ↗

Recruiting

Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery

Breast Cancer
University Hospital, Basel, Switzerland · started 2026-01-01

📍 Cork · Dublin · Galway

NCT07140172 on ClinicalTrials.gov ↗

Recruiting

The PHARO Trial: The Incidence of Para-conduit Hernia With Closure of Hiatus Versus the Standard Approach in Robotic Oesophagectomy - A Randomised Controlled Pilot Trial

Oesphageal Cancer, Para-conduit Hernia
Royal College of Surgeons, Ireland · started 2025-12-19

📍 Dublin

NCT07426835 on ClinicalTrials.gov ↗

Recruiting

Remote Vital Sign Monitoring in Palliative Care Patients Using a Wearable ECG Monitor

Cancer, Malignancies Multiple, Terminal Care, Hospice
Our Lady's Hospice and Care Services · started 2025-11-06

📍 Dublin

NCT07512505 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer, KRAS G12C Lung Cancer
Hoffmann-La Roche · started 2025-10-24

📍 Dublin

NCT06793215 on ClinicalTrials.gov ↗

Recruiting

The Lilac Device Trial - IMPACT: A Clinical Investigation on IMproving Peripheral Neuropathy Induced by Chemotherapy With Advanced Compression Technology - A Safety and Efficacy Study

Chemotherapy Induced Peripheral Neuropathy (CIPN)
Luminate Medical, Inc. · started 2025-10-03

📍 Dublin

NCT07142304 on ClinicalTrials.gov ↗

Recruiting

MCT Enteral Feeding to Reduce Chyle Leak After Oesophagectomy

Oesphageal Cancer
Royal College of Surgeons, Ireland · started 2025-10-02

📍 Beaumont

NCT07616245 on ClinicalTrials.gov ↗

Recruiting

Comparison of 'Sip Til Send' Regimens Prior to Elective Caesarean Delivery Using Bedside Gastric Ultrasound

Gastric Emptying, Caesarean Delivery, Pregnancy
The Rotunda Hospital · started 2025-08-01

📍 Dublin

NCT07407530 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)

Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
BeOne Medicines · started 2025-06-11

📍 Dublin · Galway · Limerick

NCT06943872 on ClinicalTrials.gov ↗

Active Phase 3

A Study to Evaluate Axatilimab Versus Best Available Therapy in Participants With Chronic Graft Versus Host Disease After at Least 2 Prior Lines of Systemic Therapy

Chronic Graft-versus-host-disease
Incyte Corporation · started 2025-06-04

📍 Dublin

NCT06821542 on ClinicalTrials.gov ↗

Recruiting Phase 2

WISPer: Evaluation of MTX-463 in Participants With Idiopathic Pulmonary Fibrosis (IPF)

Idiopathic Pulmonary Fibrosis
Mediar Therapeutics · started 2025-05-05

📍 Abbotstown · Drogheda · Dublin · Letterkenny

NCT06967805 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer

Carcinoma, Non-Small Cell Lung
AstraZeneca · started 2025-04-10

📍 Dublin · Galway

NCT06868277 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)

Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
Merck Sharp & Dohme LLC · started 2025-04-09

📍 Dublin

NCT06824467 on ClinicalTrials.gov ↗

Active Phase 3

Study of Bitopertin in Participants With EPP or XLP (APOLLO)

Erythropoietic Protoporphyria (EPP), X-Linked Protoporphyria (XLP)
Disc Medicine, Inc · started 2025-04-04

📍 Dublin

NCT06910358 on ClinicalTrials.gov ↗

Active Phase 3

Study of Eftilagimod Alfa (Efti) in Combination With Pembrolizumab and Chemotherapy Versus Placebo in Combination With Pembrolizumab and Chemotherapy in Participants With Metastatic Non-Small Cell Lung Cancer (NSCLC) (TACTI-004)

Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)
Immutep S.A.S. · started 2025-03-21

📍 Cork · Dublin

NCT06726265 on ClinicalTrials.gov ↗

Recruiting

Inpatient Post-Acute Rehabilitation For Patients in the Midwest: a Prospective Cohort Study of Clinical Characteristics and Process Outcomes

Rehabilitation, Frailty, Complex Patients in Rehabilitation Phase
University of Limerick · started 2025-02-22

📍 Limerick

NCT07351526 on ClinicalTrials.gov ↗

Recruiting

A Real-World Study to Gain Clinical Insights Into Faricimab (FaReal Study)

Neovascular Age-related Macular Degeneration, Diabetic Macular Edema
Hoffmann-La Roche · started 2025-02-05

📍 Dublin · Limerick · Waterford

NCT06680817 on ClinicalTrials.gov ↗

Starting soon

Burnout and Resilience in Hospital-based Nursing and Medical Personnel and Trainees

Stress, Burnout
University of Limerick · started 2025-02-01

📍 Limerick

NCT06818539 on ClinicalTrials.gov ↗

Starting soon

Rehab in Mild Stable DCM: Feasibility RCT Comparing Structured Rehabilitation to Clinical Surveillance

Degenerative Cervical Myelopathy
Royal College of Surgeons, Ireland · started 2025-01-13

📍 Dublin

NCT06781658 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease

Crohn's Disease
Takeda · started 2025-01-02

📍 Dublin

NCT06227910 on ClinicalTrials.gov ↗

Starting soon

AUGUR-AI - Indocyanine Green Fluorescence Angiography Representer

Colorectal Surgery, Colorectal Resection, Anastomosis, Surgical, Fluorescence Guided Surgery
Mater Misericordiae University Hospital · started 2025-01

📍 Dublin

NCT06708819 on ClinicalTrials.gov ↗

Active Phase 3

Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults With HAE

Hereditary Angioedema (HAE)
Pharvaris Netherlands B.V. · started 2024-12-01

📍 Dublin

NCT06669754 on ClinicalTrials.gov ↗

Recruiting

SYMPHONY™ OCT System for Instabilities of the Upper Thoracic and Cervical Spine

Cervical Instabilities Spine, Spine; Instability
University College Dublin · started 2024-12-01

📍 Dublin

NCT06816862 on ClinicalTrials.gov ↗

Recruiting Phase 2

CATALINA-2: A Clinical Study of TORL-1-23 in Platinum-resistant Ovarian Cancer.

Epithelial Ovarian Cancer, Primary Peritoneal, Fallopian Tube Cancer, Endometrioid Ovarian Cancer
TORL Biotherapeutics, LLC · started 2024-11-20

📍 Dublin

NCT06690775 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%

Non-small Cell Lung Cancer
Bristol-Myers Squibb · started 2024-10-07

📍 Dublin

NCT06561386 on ClinicalTrials.gov ↗

By invitation

Linguistically Tailored Health Messages to Encourage Plant-Based Food Choices in Adolescents

Food Consumption, Sustainable Food Consumption, Sustainable Healthy Eating Behaviour
Erasmus University Rotterdam · started 2024-10-04

📍 London

NCT06742346 on ClinicalTrials.gov ↗

Recruiting

ENVELOP: Wound Care Following Pilonidal Sinus Surgery

Pilonidal Sinus, Wound Healing
Royal College of Surgeons, Ireland · started 2024-10-01

📍 Castlebar · Cork · Dublin · Galway · Kilkenny · Limerick

NCT06647290 on ClinicalTrials.gov ↗

Recruiting

Implementation of a Standardized Algorithm for Coronary Calcification With Plaque Modification

Myocardial Ischaemia, Severely Calcified Coronary Stenoses, Coronary Calcification
Royal College of Surgeons, Ireland · started 2024-09-24

📍 Dublin

NCT06678594 on ClinicalTrials.gov ↗

Active

Safety and Tolerance of a Novel Three-Strain Probiotic in Healthy Adults

Healthy Adults
Pendulum Therapeutics · started 2024-09-23

📍 Cork

NCT07566884 on ClinicalTrials.gov ↗

Recruiting Phase 2

A Proof-of-Concept Study to Learn Whether Linvoseltamab Can Eliminate Abnormal Plasma Cells That May Lead to Multiple Myeloma in Adult Patients With High-Risk Monoclonal Gammopathy of Undetermined Significance or Non-High-Risk Smoldering Multiple Myeloma

Monoclonal Gammopathy of Undetermined Significance (MGUS), Smoldering Multiple Myeloma (SMM)
Regeneron Pharmaceuticals · started 2024-09-16

📍 Galway · Cork · Dublin

NCT06140524 on ClinicalTrials.gov ↗

Active Phase 3

Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)

Pulmonary Arterial Hypertension
GB002, Inc. · started 2024-09-03

📍 Dublin

NCT06274801 on ClinicalTrials.gov ↗

Recruiting

Community-based Exercise for Older Adults With Chronic Musculoskeletal Pain

Chronic Musculoskeletal Pain
University of Limerick · started 2024-09-01

📍 Limerick

NCT06535633 on ClinicalTrials.gov ↗

Recruiting

Abbott Structural Heart Device Registry

Heart Diseases, ASD - Atrial Septal Defect, VSD - Muscular Ventricular Septal Defect, PFO - Patent Foramen Ovale
Abbott Medical Devices · started 2024-08-21

📍 Crumlin

NCT06590467 on ClinicalTrials.gov ↗

Recruiting

Prophylactic Surfactant by Thin Endotracheal Catheter for Preterm Infants At Birth: the ProTeCt Trial

Infant, Newborn, Diseases, Prematurity, Prematurity; Extreme, Respiratory Distress Syndrome in Premature Infant
University College Dublin · started 2024-08-19

📍 Dublin

NCT06557551 on ClinicalTrials.gov ↗

Recruiting

The Effect of a Post-operative Exercise Programme Versus Standard Care on Physical Fitness of Patients With Breast Cancer Undergoing Deep Inferior Epigastric Perforator (DIEP) Flap Reconstruction Surgery

Breast Cancer, Exercise
Royal College of Surgeons, Ireland · started 2024-08-01

📍 Beaumont

NCT07672392 on ClinicalTrials.gov ↗

Recruiting Phase 3

Preventing Cardiovascular Collapse With Vasopressors During Tracheal Intubation

Critical Illness, Respiratory Failure
University of Turin, Italy · started 2024-08-01

📍 Galway

NCT05014581 on ClinicalTrials.gov ↗

Active Phase 2

A Phase 2 Clinical Trial to Evaluate Efficacy, Safety, and Tolerability of Navepegritide in Combination With Lonapegsomatropin in Children With Achondroplasia

Achondroplasia
Ascendis Pharma Growth Disorders A/S · started 2024-07-26

📍 Dublin

NCT06433557 on ClinicalTrials.gov ↗

Active Phase 2

Long-term, Open-label Study of SAR447537 (INBRX-101) in Adults With Alpha-1 Antitrypsin Deficiency Emphysema

Alpha 1-Antitrypsin Deficiency, Emphysema
Sanofi · started 2024-06-20

📍 Dublin

NCT05897424 on ClinicalTrials.gov ↗

Recruiting Phase 1/Phase 2

A Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD)

Alpha 1-Antitrypsin Deficiency
Beam Therapeutics Inc. · started 2024-06-19

📍 Dublin

NCT06389877 on ClinicalTrials.gov ↗

By invitation

Prostate Cancer Awareness and Initiative for Screening in the European Union

Prostate Cancer
European Association of Urology Research Foundation · started 2024-06-01

📍 Dublin

NCT06424275 on ClinicalTrials.gov ↗

By invitation Phase 3

A Long-term Extension Study to Assess the Long-term Safety and Efficacy of Pegtibatinase Treatment in Participants ≥5 to ≤65 Years of Age With Classical Homocystinuria (HCU) (ENSEMBLE)

Homocystinuria
Travere Therapeutics, Inc. · started 2024-04-30

📍 Dublin

NCT06431893 on ClinicalTrials.gov ↗

Recruiting Phase 2

A Study To Evaluate The Efficacy And Safety Of Ifinatamab Deruxtecan (I-DXd) In Subjects With Recurrent Or Metastatic Solid Tumors (IDeate-PanTumor02)

Recurrent or Metastatic Solid Tumors
Daiichi Sankyo · started 2024-04-10

📍 Cork · Dublin · Galway

NCT06330064 on ClinicalTrials.gov ↗

Recruiting

Remote Assessment of Signs and Symptoms in Palliative Care

Palliative Care, Vital Signs, Remote Monitoring
Our Lady's Hospice and Care Services · started 2024-04-01

📍 Dublin

NCT06587321 on ClinicalTrials.gov ↗

Recruiting

PENG Block: Continuous Infusion vs. Programmed Intermittent Bolus in Neck of Femur Fracture

Hip Fracture, Analgesia Post Fracture
University College Cork · started 2024-03-28

📍 Cork

NCT07046052 on ClinicalTrials.gov ↗

Active Phase 2

A Study to Assess Adverse Events and Change in Disease Activity From Intravenous (IV) and Subcutaneous (SC) Lutikizumab in Adult Participants With Active Ulcerative Colitis

Ulcerative Colitis
AbbVie · started 2024-03-23

📍 Elm Park · Dublin

NCT06257875 on ClinicalTrials.gov ↗

Active

Essilor® Stellest® Lenses Multicentre European Study (SLOMES)

Myopia
Essilor International · started 2024-03-22

📍 Dublin

NCT06263946 on ClinicalTrials.gov ↗

Recruiting

The NEU-STIM Trial

Infant, Premature, Diseases, Birth, Preterm
Leiden University Medical Center · started 2024-03-11

📍 Dublin · Galway

NCT05942924 on ClinicalTrials.gov ↗

Recruiting

PINTA - Prophylactic Incisional Negative Pressure Therapy for Major Amputations

Wound Surgical, Wound Infection, Cosmesis
Royal College of Surgeons, Ireland · started 2024-03-01

📍 Dublin · Galway · Limerick · Waterford

NCT06025253 on ClinicalTrials.gov ↗

Active Phase 3

A Study to Evaluate the Efficacy, Safety, and Tolerability of Using an Oral Once-daily 2 Drug Regimen Compared to an Oral Once-daily 3 Drug Regimen for the Treatment of Human Immunodeficiency Virus (HIV)-1 in Adults Who Have Not Previously Taken Antiretroviral Therapy

HIV, HIV Infections
ViiV Healthcare · started 2024-02-21

📍 Dublin

NCT05979311 on ClinicalTrials.gov ↗

Active

Assessment of Diastolic Function During the Transitional Period and Infancy Using Serial Echocardiography

Diastolic Dysfunction, Neonatal Encephalopathy, Small for Gestational Age at Delivery, Transient Tachypnea of the Newborn
University College Cork · started 2024-02-12

📍 Cork

NCT06200519 on ClinicalTrials.gov ↗

Recruiting Phase 1/Phase 2

Dose-Painted Intensity Modulated Radiotherapy Pancreas (DP-IMRT Pancreas)

Pancreatic Adenocarcinoma
Cancer Trials Ireland · started 2024-01-30

📍 Dublin

NCT06024824 on ClinicalTrials.gov ↗

Recruiting Phase 3

Trastuzumab Deruxtecan (T-DXd) in Patients Who Have Hormone Receptor-negative and Hormone Receptor-positive HER2-low or HER2 IHC 0 Metastatic Breast Cancer

Breast Cancer
Daiichi Sankyo · started 2023-12-30

📍 Cork · Dublin · Galway

NCT05950945 on ClinicalTrials.gov ↗

Active Phase 3

Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005)

Endometrial Cancer
Merck Sharp & Dohme LLC · started 2023-12-06

📍 Cork · Dublin

NCT06132958 on ClinicalTrials.gov ↗

Recruiting Phase 3

Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients

Non-Small Cell Lung Cancer
Summit Therapeutics · started 2023-10-26

📍 Dublin · Galway

NCT05899608 on ClinicalTrials.gov ↗

Active Phase 3

A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Idiopathic Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis
Bristol-Myers Squibb · started 2023-09-14

📍 Drogheda · Dublin

NCT06003426 on ClinicalTrials.gov ↗

Recruiting

TQ-PAL Development and Validation

Altered Taste
Prof Andrew Davies · started 2023-09-01

📍 Dublin

NCT06588933 on ClinicalTrials.gov ↗

By invitation

Long-term Follow-up Study of Male Adults With Hemophilia B Previously Treated With Etranacogene Dezaparvovec (CSL222)

Hemophilia B
CSL Behring · started 2023-08-30

📍 Dublin

NCT05962398 on ClinicalTrials.gov ↗

Active

BioDulse II: The Effect of an Irish Seaweed Protein Extract on Glucose Control in Adults With Type 2 Diabetes

Type 2 Diabetes
University of Limerick · started 2023-08-07

📍 Limerick

NCT05986253 on ClinicalTrials.gov ↗

Active Phase 2

Adagrasib in Patients With KRASG12C-mutant NSCLC Who Are Elderly or Have Poor Performance Status

NSCLC Stage IV, KRAS P.G12C
ETOP IBCSG Partners Foundation · started 2023-06-12

📍 Dublin · Limerick · Waterford

NCT05673187 on ClinicalTrials.gov ↗

Active Phase 3

Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma

Endometrial Cancer
Karyopharm Therapeutics Inc · started 2023-04-18

📍 Dublin · Cork · Galway · Waterford

NCT05611931 on ClinicalTrials.gov ↗

Recruiting

CLASSICA: Validating AI in Classifying Cancer in Real-Time Surgery

Rectum Neoplasm, Rectum Polyp, Rectal Cancer
Mater Misericordiae University Hospital · started 2023-03-31

📍 Dublin

NCT05793554 on ClinicalTrials.gov ↗

Active Phase 3

Study to Evaluate the Safety and Efficacy of Tafasitamab Plus Lenalidomide in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (firmMIND)

Large B-Cell Lymphoma, Diffuse Large B-Cell Lymphoma
Incyte Corporation · started 2022-12-23

📍 Cork · Dublin · Galway

NCT05429268 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

Colorectal Neoplasms
Seagen, a wholly owned subsidiary of Pfizer · started 2022-10-24

📍 Cork · Dublin · Waterford

NCT05253651 on ClinicalTrials.gov ↗

Active Phase 3

A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer

Breast Neoplasms
Eli Lilly and Company · started 2022-10-04

📍 Cork · Dublin · Galway · Sligo · Waterford

NCT05514054 on ClinicalTrials.gov ↗

Active Phase 3

A Phase III Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Non Small Cell Lung Cancer (NSCLC) Whose Disease Progressed On or After Prior Anti PD (L)1 Therapy And Platinum Based Chemotherapy

Advanced or Metastatic Non-Small Cell Lung Cancer
AstraZeneca · started 2022-09-15

📍 Cork · Dublin · Limerick

NCT05450692 on ClinicalTrials.gov ↗

Active Phase 2

Isa-RVD Study in Patients With Newly Diagnosed Multiple Myeloma

Multiple Myeloma
Cancer Trials Ireland · started 2022-04-01

📍 Dublin · Waterford

NCT05123131 on ClinicalTrials.gov ↗

Recruiting Phase 2/Phase 3

Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney Disease

Proteinuric Kidney Disease
Vertex Pharmaceuticals Incorporated · started 2022-03-30

NCT05312879 on ClinicalTrials.gov ↗

Active Phase 3

A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)

Carcinoma, Renal Cell
Merck Sharp & Dohme LLC · started 2022-03-15

📍 Dublin · Cork

NCT05239728 on ClinicalTrials.gov ↗

Active

Direct Measurement of Microstructure of Ingestive Behaviour After Initiation of GLP-1 Receptor Agonist Treatment at Maximum Dose (DIGRAT)

Metabolic Disease, Obesity & Overweight
University College Dublin · started 2022-02-17

📍 Dublin

NCT07457424 on ClinicalTrials.gov ↗

Active Phase 2/Phase 3

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)

Alzheimers Disease, Dementia, Alzheimers Disease, Familial
Washington University School of Medicine · started 2021-12-22

📍 Dublin

NCT05269394 on ClinicalTrials.gov ↗

Active Phase 3

A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Cilta-cel, a CAR-T Therapy Directed Against BCMA Versus VRd Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom ASCT is Not Planned as Initial Therapy

Multiple Myeloma
Janssen Research & Development, LLC · started 2021-08-19

📍 Dublin

NCT04923893 on ClinicalTrials.gov ↗

Recruiting Phase 3

Vitrectomy, Subretinal Tissue Plasminogen Activator (TPA) and Intravitreal Gas for Submacular Haemorrhage Secondary to Exudative (Wet) Age-related Macular Degeneration (TIGER).

Eye Diseases, Macular Degeneration, Wet, Sub-Macular Hemorrhage
King's College Hospital NHS Trust · started 2021-04-16

📍 Waterford

NCT04663750 on ClinicalTrials.gov ↗

Recruiting

Medication Following Bariatric Surgery for Type 2 Diabetes Mellitus

Obesity, Type 2 Diabetes
Imperial College London · started 2021-04-01

📍 Dublin

NCT04432025 on ClinicalTrials.gov ↗

Active Phase 3

A Study of Inebilizumab Efficacy and Safety in IgG4- Related Disease

IgG4 Related Disease
Amgen · started 2020-12-04

📍 Cork

NCT04540497 on ClinicalTrials.gov ↗

Recruiting Phase 2/Phase 3

Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer
Mirati Therapeutics Inc. · started 2020-12-02

📍 Cork · Dublin · Galway · Limerick · Waterford

NCT04613596 on ClinicalTrials.gov ↗

Recruiting Phase 3

Chemoradiotherapy Followed by Planned Surgery or by Surveillance and Surgery Only When Needed for Oesophageal Cancer

Esophageal Squamous Cell Carcinoma
Karolinska University Hospital · started 2020-11-27

📍 Dublin

NCT04460352 on ClinicalTrials.gov ↗

Active Phase 3

A Study to Compare Safety and Efficacy of High Doses of Eteplirsen in Participants With Duchenne Muscular Dystrophy (DMD) (MIS51ON)

Muscular Dystrophy, Duchenne
Sarepta Therapeutics, Inc. · started 2020-07-13

📍 Dublin

NCT03992430 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia

Leukemia, Acute Lymphoblastic
Mats Heyman · started 2020-07-13

📍 Dublin

NCT04307576 on ClinicalTrials.gov ↗

Active Phase 3

Darolutamide Augments Standard Therapy for Localised Very High-Risk Cancer of the Prostate

Prostate Cancer
University of Sydney · started 2020-03-31

📍 Rathgar · Cork · Dublin · Galway

NCT04136353 on ClinicalTrials.gov ↗

Recruiting

TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention

BRCA1 Gene Mutation, BRCA2 Gene Mutation, RAD51C Gene Mutation, RAD51D Gene Mutation
University Medical Center Nijmegen · started 2020-03-01

📍 Cork

NCT04294927 on ClinicalTrials.gov ↗

Active

PROACTIVE-HF IDE Trial Heart Failure NYHA Class III

Heart Failure NYHA Class III
Endotronix, Inc. · started 2020-01-10

📍 Galway

NCT04089059 on ClinicalTrials.gov ↗

Active Phase 3

A Study of Gilteritinib Versus Midostaurin in Combination With Induction and Consolidation Therapy Followed by One-year Maintenance in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndromes With Excess Blasts-2 With FLT3 Mutations Eligible for Intensive Chemotherapy

Acute Myeloid Leukemia, Myelodysplastic Syndrome With Excess Blasts-2
Stichting Hemato-Oncologie voor Volwassenen Nederland · started 2019-12-20

📍 Cork · Dublin · Galway · Limerick

NCT04027309 on ClinicalTrials.gov ↗

Recruiting Phase 3

Phase III, Efficacy and Safety of "Kamada-AAT for Inhalation"

Alpha 1-Antitrypsin Deficiency
Kamada, Ltd. · started 2019-11-25

📍 Dublin

NCT04204252 on ClinicalTrials.gov ↗

Active Phase 2

Efficacy, Safety and Tolerability of Nangibotide in Patients With Septic Shock

Shock, Septic
Inotrem · started 2019-11-13

📍 Dublin · Galway

NCT04055909 on ClinicalTrials.gov ↗

Active Phase 3

Study of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-3475-641/KEYNOTE-641)

Prostatic Neoplasms
Merck Sharp & Dohme LLC · started 2019-07-28

📍 Dublin · Limerick

NCT03834493 on ClinicalTrials.gov ↗

Active Phase 3

Study of Adjuvant Cemiplimab Versus Placebo After Surgery and Radiation Therapy in Patients With High Risk Cutaneous Squamous Cell Carcinoma

Cutaneous Squamous Cell Carcinoma
Regeneron Pharmaceuticals · started 2019-06-04

📍 Dublin · Cork · Galway

NCT03969004 on ClinicalTrials.gov ↗

Recruiting Phase 2

A Clinical Efficacy and Safety Study of OHB-607 in Preventing Bronchopulmonary Dysplasia in Extremely Premature Infants

Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity, Intraventricular Hemorrhage, Retinopathy of Prematurity (ROP)
OHB Neonatology Ltd. · started 2019-05-09

📍 Cork

NCT03253263 on ClinicalTrials.gov ↗

Active Phase 3

Phase III Study in First-line Treatment of Patients With Metastatic Colorectal Cancer Who Are Not Candidate for Intensive Therapy.

Metastatic Colorectal Cancer
Institut de Recherches Internationales Servier · started 2019-03-21

📍 Cork · Dublin

NCT03869892 on ClinicalTrials.gov ↗

Active Phase 3

A Trial to Evaluate Efficacy and Safety of Ribociclib With Endocrine Therapy as Adjuvant Treatment in Patients With HR+/HER2- Early Breast Cancer

Early Breast Cancer
Novartis Pharmaceuticals · started 2018-12-07

📍 Wilton · County Limerick · Dublin · Waterford

NCT03701334 on ClinicalTrials.gov ↗

Active Phase 3

A Study of Zolbetuximab (IMAB362) Plus CAPOX Compared With Placebo Plus CAPOX as First-line Treatment of Subjects With Claudin (CLDN) 18.2-positive, HER2-negative, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (GLOW).

Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Metastatic Gastric Adenocarcinoma or Cancer, Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma
Astellas Pharma Global Development, Inc. · started 2018-11-28

📍 Dublin

NCT03653507 on ClinicalTrials.gov ↗

Active Phase 2

Study of Telisotuzumab Vedotin (ABBV-399) in Participants With Previously Treated c-Met+ Non-Small Cell Lung Cancer

Non-small Cell Lung Cancer
AbbVie · started 2018-10-10

📍 Wilton · Dublin · Elm Park

NCT03539536 on ClinicalTrials.gov ↗

Active Phase 3

A Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 3)

Ulcerative Colitis
Eli Lilly and Company · started 2018-07-18

📍 Dublin

NCT03519945 on ClinicalTrials.gov ↗