Active, not recruiting
Phase 2/Phase 3
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)
Condition(s) studied
Alzheimers DiseaseDementiaAlzheimers Disease, Familial
Investigational drug(s) / intervention(s)
E2814LecanemabMatching Placebo (E2814)
E2814: Administered intravenously in a blinded fashion
Lecanemab: Administered intravenously
Matching Placebo (E2814): Placebo administered intravenously in a blinded fashion.
Study summary
To assess the safety, tolerability, biomarker, cognitive, and clinical efficacy of investigational products in participants with an Alzheimer's disease-causing mutation by determining if treatment with the study drug improves disease-related biomarkers and slows the rate of progression of cognitive or clinical impairment.
Eligibility
Key Inclusion Criteria:
* Between 18-80 years of age
* Individuals who know they have an Alzheimer's disease-causing mutation.
* Are within -10 to + 10 years of the predicted or actual age of cognitive symptom onset.
* Cognitively normal or with mild cognitive impairment or mild dementia, Clinical Dementia Rating (CDR) of 0-1 (inclusive)
* Fluency in DIAN-TU trial approved language and evidence of adequate premorbid intellectual functioning
* Able to undergo Magnetic Resonance Imaging (MRI), Lumbar Puncture (LP), Positron Emission Tomography (PET), and complete all study related testing and evaluations.
* For women of childbearing potential, if partner is not sterilized, participant must agree to use effective contraceptive measures (hormonal contraception, intra-uterine device, sexual abstinence, barrier method with spermicide).
* Adequate visual and auditory abilities to perform all aspects of the cognitive and functional assessments.
* Has a Study Partner who in the investigator's judgment is able to provide accurate information as to the subject's cognitive and functional abilities, who agrees to provide information at the study visits which require informant input for scale completion.
Key Exclusion Criteria:
* Significant neurologic disease (other than AD) or psychiatric disease that may currently or during the course of the study affect cognition or participant's ability to complete the study.
* At high risk for suicide, e.g., significant suicidal ideation or attempt within last 12 months. Current stable mild depression or current use of antidepressant medications is not exclusionary.
* History or presence of brain MRI scans indicative of any other significant abnormality
* Substance or alcohol use disorder currently or within the past 1 year
* Presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, or foreign metal objects in the eyes, skin or body which would preclude MRI scan.
* History or presence of clinically significant cardiovascular disease, hepatic/renal disorders, infectious disease or immune disorder, or metabolic/endocrine disorders
* Anticoagulants except low dose (≤ 325 mg) aspirin.
* Have been exposed to a monoclonal antibody targeting beta amyloid peptide within the past six months.
* History of cancer within the last 5 years, except basal cell carcinoma, non-squamous skin carcinoma, prostate cancer or carcinoma in situ with no significant progression over the past 2 years.
* Positive urine or serum pregnancy test or plans or desires to become pregnant during the course of the trial.
* Subjects unable to complete all study related testing, including implanted metal that cannot be removed for MRI scanning, required anticoagulation and pregnancy.
Primary outcome measure(s)
- The primary end point is the change from Week 24 to Week 104 and Week 208 in tau PET in the Symptomatic Population (Cohort 1). — Weeks 24, 104, and 208
To determine whether E2814 is superior to placebo, when each is concurrently administered with lecanemab, in the change from Week 24 to Week 104 (interim analysis) and Week 208 (final analysis) in tau spread as measured by tau PET in the symptomatic population (Cohort 1).
Trial sites (36)
| Facility | City | Region | Status |
| University of Alabama in Birmingham |
Birmingham |
Alabama |
|
| University of California San Diego Medical Center |
La Jolla |
California |
|
| USC Keck School of Medicine |
Los Angeles |
California |
|
| Yale University School of Medicine |
New Haven |
Connecticut |
|
| Emory University |
Atlanta |
Georgia |
|
| Advocate Lutheran General Hospital |
Park Ridge |
Illinois |
|
| Indiana University School of Medicine |
Indianapolis |
Indiana |
|
| Washington University in St. Louis |
St Louis |
Missouri |
|
| University of Pittsburgh |
Pittsburgh |
Pennsylvania |
|
| Butler Hospital |
Providence |
Rhode Island |
|
| Kerwin Research Center, |
Dallas |
Texas |
|
| University of Washington |
Seattle |
Washington |
|
| Instituto de Investigaciones Neurologicas Raul Carrea, FLENI |
Ciudad Autonoma de Buenos Aire |
Argentina |
|
| Neuroscience Research Australia |
Randwick |
New South Wales |
|
| Alzheimer's Research Australia |
Melbourne |
Victoria |
|
| Hospital das Clínicas da Faculdade de Medicina da USP |
São Paulo |
Brazil |
|
| Sunnybrook Health Sciences Centre |
Toronto |
Ontario |
|
| McGill Center for Studies in Aging |
Verdun |
Quebec |
|
| CHU de Quebec - Hôpital de l' Enfant Jésus |
Québec |
Canada |
|
| Grupo de Neurociencias Sede de la Universidad de Antioquia |
Medellín |
Colombia |
|
| CHU de Toulouse - Hôpital Purpan |
Toulouse |
Haute Garonne |
|
| Hopital Roger Salengro - CHU Lille |
Lille |
Nord |
|
| Groupe Hospitalier Pitie-Salpetriere |
Paris |
Paris |
|
| Hopital Neurologique Pierre Wertheimer |
Bron |
Rhone |
|
| CHU de Rouen - Hôpital Charles Nicolle |
Rouen |
Seine Maritime |
|
| Universitaetsklinikum Tubingen |
Tübingen |
Baden-Wurttemberg |
|
| LMU-Campus Grosshadern |
Munich |
Bavaria |
|
| St Vincent's University Hospital |
Dublin |
Ireland |
|
| IRCCS Centro San Giovanni di Dio Fatebenefratelli |
Brescia |
Italy |
|
| Azienda Ospedaliera Universitaria Careggi |
Florence |
Italy |
|
| University of Tokyo Hospital |
Bunkyō City |
Tokyo-To |
|
| Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez |
Mexico City |
Mexico City |
|
| Brain Research Center |
Amsterdam |
Netherlands |
|
| University of Puerto Rico, School of Medicine |
San Juan |
Puerto Rico |
|
| Hospital Clínic I Provincial de Barcelona |
Barcelona |
Spain |
|
| The National Hospital for Neurology and Neurosurgery |
London |
Greater London |
|