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Compound · clinical trials

Nemtabrutinib

Also listed in trial records as MK-1026, ARQ 531
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 7 trials in our USA, UK, China and Ireland registers that name Nemtabrutinib as an intervention. Synced 24 Sep 2026
7Trials tracked
4Recruiting now
2Lead sponsors
4Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards

Nemtabrutinib is named as a drug or biological intervention in 7 clinical trials in our USA, UK, China and Ireland trial registers, 4 of which are recruiting. Lead sponsors include Merck Sharp & Dohme LLC (6) and ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA) (1). Registered phases: Phase 3, Phase 2, Phase 1 and Phase 1/2. Conditions studied include Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma; Mantle Cell Lymphoma.

01

Clinical trials of Nemtabrutinib

7 trials
NCT IDStudyPhaseStatusLead sponsorRegister
NCT05947851 A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010). (ClinicalTrials.gov ↗)
Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Chronic Lymphocytic, Small-Cell Lymphoma
Phase 3 Recruiting Merck Sharp & Dohme LLC UK, USA
NCT06136559 A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Phase 3 Recruiting Merck Sharp & Dohme LLC UK, USA, China
NCT04728893 Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003) (ClinicalTrials.gov ↗)
Hematologic Malignancies, Waldenstroms Macroglobulinaemia, Non-Hodgkins Lymphoma
Phase 2 Recruiting Merck Sharp & Dohme LLC Ireland, UK, USA, China
NCT07734610 A Clinical Trial of Nemtabrutinib in Participants With Severe Kidney Disease (MK-1026-027) (ClinicalTrials.gov ↗)
Severe Renal Impairment, Healthy
Phase 1 Recruiting Merck Sharp & Dohme LLC USA
NCT05624554 A Study of Nemtabrutinib vs Chemoimmunotherapy for Participants With Previously Untreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) Without TP53 Aberrations (MK-1026-008, BELLWAVE-008) (ClinicalTrials.gov ↗)
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Phase 3 Active, closed Merck Sharp & Dohme LLC USA, China
NCT05458297 A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006) (ClinicalTrials.gov ↗)
Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Follicular Lymphoma
Phase 2 Active, closed Merck Sharp & Dohme LLC Ireland, UK, USA, China
NCT03162536 A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001) (ClinicalTrials.gov ↗)
Lymphoma, B-Cell, Small Lymphocytic Lymphoma, Chronic Lymphocytic Leukemia
Phase 1/2 Active, closed ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA) USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied

17 conditions
Condition (as registered)Trials
Chronic Lymphocytic Leukemia4
Small Lymphocytic Lymphoma3
Mantle Cell Lymphoma1
Follicular Lymphoma1
Richter Transformation Lymphoma1
Hematologic Malignancies1
Waldenstroms Macroglobulinaemia1
Non-Hodgkins Lymphoma1
Chronic Lymphocytic Leukaemia1
Leukemia, Lymphocytic, Chronic, B-Cell1
Leukemia, Chronic Lymphocytic1
Small-Cell Lymphoma1
Lymphoma, Small Lymphocytic1
Severe Renal Impairment1
Healthy1
Lymphoma, B-Cell1
Waldenstrom Macroglobulinemia1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Merck Sharp & Dohme LLC6
ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)1
04

Trials by country register

A trial with sites in more than one country appears in each of those registers.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Nemtabrutinib works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Nemtabrutinib (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 24 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.