Ireland
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Priya Life Science Compound trial record
Compound · clinical trials

Iberdomide clinical trials

Also listed in trial records as CC-220, BMS-986382, C25H28N3O5Cl
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 20 trials in our USA, Israel, Spain, Australia, France, Canada, Netherlands, UK, Germany, Italy, Japan, Poland, South Korea, Austria, Norway, Taiwan, India, China, Belgium, Sweden, Denmark, Czechia, Portugal, Turkey, Brazil, Mexico, Ireland, Switzerland and Singapore registers that name Iberdomide as an intervention. Synced 10 Nov 2026
20Current trials
8Recruiting now
14Lead sponsors
29Country registers
At a glance

Iberdomide is named as an intervention in 20 current clinical trials in our USA, Israel, Spain, Australia, France, Canada, Netherlands, UK, Germany, Italy, Japan, Poland, South Korea, Austria, Norway, Taiwan, India, China, Belgium, Sweden, Denmark, Czechia, Portugal, Turkey, Brazil, Mexico, Ireland, Switzerland and Singapore registers. 8 are recruiting patients now. The most common phase is Phase 1. The sponsor with the most trials is Celgene (3). The most-studied condition is Multiple Myeloma.

Where Iberdomide is approved

All regulators →

Of the three regulators tracked here, the first to approve Iberdomide was the US, on 13 Aug 2026.

USUnited States (FDA)
13 Aug 2026
Zenbexus
NDA221075 on Drugs@FDA
First original NDA/BLA approval
EUEuropean Union (EMA)
No centralised EU authorisation (it may be authorised nationally)
First centralised authorisation
CACanada (Health Canada)
No new-drug Notice of Compliance since 1994
First new-drug NOC

From the regulators' own registers: FDA Drugs@FDA, the EMA medicines list and Health Canada's Notice of Compliance database. Dates are the first listed approval of a product containing only this substance; combination products and nationally authorised EU medicines are not counted.

Iberdomide patents and exclusivity

Expiry tracker →

Protections still running for marketed products containing Iberdomide, as listed by the regulators. Expired patents and exclusivities, and discontinued products, are not shown.

US FDA Orange Book Zenbexus
  • 7 listed patents; the last listed expires 30 Sep 2039 (US 11529339).
  • Latest patent on the drug substance itself: 25 Sep 2033 (US 9221788).
  • Exclusivity NCE: New chemical entity, until 13 Aug 2031.
See the Orange Book listing for NDA 221075

Reproduced from the FDA Orange Book and Purple Book (checked 8 Nov 2026) and the European Commission's Union Register of medicinal products (CC BY 4.0; the EU expiry date is calculated exactly as the Commission's register displays it). Listed patents and dates are as submitted to or published by the regulator and may not reflect litigation, invalidation, settlements, lapsed fees or later extensions. This is not legal advice or a freedom-to-operate opinion, and it does not say when a generic or biosimilar will launch.

How Iberdomide works

All drug targets →
  • CRL4(CRBN) E3 ubiquitin ligase modulator Modulator
    Target: CRL4(CRBN) E3 ubiquitin ligase
    ✓ In ChEMBL and the Guide to Pharmacology
Diseases it has been tested for in clinical trials, by furthest phase
  • Plasma cell myelomaPhase 3
  • SarcoidosisPhase 2
  • Skin sarcoidosisPhase 2
  • Smoldering plasma cell myelomaPhase 2
  • Systemic lupus erythematosusPhase 2
  • NeuroblastomaPhase 1/2
  • Non-Hodgkin lymphomaPhase 1

Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL3989927, CC BY-SA 3.0. Targets checked against the IUPHAR/BPS Guide to PHARMACOLOGY (2026.3.1), ligand 9618, CC BY-SA 4.0. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.

Patient leaflets for Iberdomide

The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.

  • UK
    United Kingdom: Search MHRA Products
    Patient information leaflets and SmPCs for UK-licensed products.
  • US
    United States: Search DailyMed
    FDA-approved labels, including patient and medication guides.

Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.

Trials by status

  • Recruiting840%
  • Not yet open15%
  • Active, closed1155%

Trials by phase

  • Phase 1630%
  • Phase 3525%
  • Phase 2525%
  • Phase 1/2420%
01

Clinical trials of Iberdomide

20 trials
StudyPhaseStatusLead sponsorRegisters
NDMM Patients Candidates for ASCT Comparing Extended VRD Plus vs. Isa-VRD vs. Isa-V-Iberdomide
NCT05558319 · ClinicalTrials.gov ↗ · Newly Diagnosed Multiple Myeloma
Phase 3 Recruiting PETHEMA Foundation Spain
D2 - Isa-Iber-VD Induction, Followed by Risk & Response Adapted Consolidation & Maintenance, in Transplant-Eligible NDMM
NCT07624513 · ClinicalTrials.gov ↗ · Multiple Myeloma
Phase 3 Recruiting Dana-Farber Cancer Institute Israel
Study of Iberdomide, Bortezomib, Dexamethasone With Isatuximab Added on Demand for ND-NTE MM Patients
NCT05272826 · ClinicalTrials.gov ↗ · Multiple Myeloma
Phase 2 Recruiting Canadian Myeloma Research Group Canada
A Study Evaluating the Safety and Efficacy of Multiple Treatments in Participants With Multiple Myeloma
NCT05583617 · ClinicalTrials.gov ↗ · Multiple Myeloma
Phase 1/2 Recruiting Hoffmann-La Roche Germany, France, Spain, Poland, South Korea, Australia
A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Multiple Myeloma Receiving T Cell Engaging Bi/Tri-specific Antibodies Intravenously (IV)/Subcutaneously (SC) Alone or in Combinations
NCT06892522 · Multiple Myeloma
Phase 1/2 Recruiting AbbVie UK, USA, Norway, Japan, Australia, Israel
A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma
NCT06121843 · Multiple Myeloma
Phase 1 Recruiting Juno Therapeutics, Inc., a Bristol-Myers Squibb Company USA, Canada, Israel
ELEVATE-MM: Elotuzumab, Iberdomide and Dexamethasone Post Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma
NCT06518551 · ClinicalTrials.gov ↗ · Myeloma, Multiple Myeloma, Refractory Multiple Myeloma
Phase 1 Recruiting Omar Nadeem, MD Israel
Study of Intravenously (IV) Infused Etentamig in Combination With an Oral Cereblon E3 Ligase Modulatory Drug (CELMoD) Agent Assessing Adverse Events and Change in Disease Activity in Adult Participants With Relapsed or Refractory Multiple Myeloma
NCT06896916 · Multiple Myeloma
Phase 1 Recruiting AbbVie USA, France, Netherlands, Norway, Canada, Japan, Australia
Isatuximab, Iberdomide, Bortezomib, Dexamethasone in Transplant Ineligible/Deferred Newly Diagnosed Myeloma
NCT07601100 · ClinicalTrials.gov ↗ · Newly Diagnosed Multiple Myeloma
Phase 1/2 Not yet open Dana-Farber Cancer Institute Israel
Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
NCT04975997 · Multiple Myeloma
Phase 3 Active, closed Celgene Ireland, UK, USA, India, China, Germany, France, Spain, Italy, Netherlands, Belgium, Sweden, Denmark, Poland, Switzerland, Austria, Czechia, Norway, Portugal, Turkey, Canada, Brazil, Mexico, Japan, South Korea, Taiwan, Australia, Israel
A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma
NCT05827016 · Multiple Myeloma
Phase 3 Active, closed Bristol-Myers Squibb UK, USA, India, China, Germany, France, Spain, Italy, Netherlands, Belgium, Sweden, Denmark, Poland, Austria, Czechia, Portugal, Turkey, Canada, Brazil, Mexico, Japan, South Korea, Taiwan, Singapore, Australia, Israel
Iberdomide vs. Iberdomide Plus Isatuximab Maintenance Therapy Post ASCT in Newly Diagnosed Multiple Myeloma
NCT06216158 · ClinicalTrials.gov ↗ · Multiple Myeloma
Phase 3 Active, closed University of Heidelberg Medical Center Germany, Austria
Iberdomide Combined With Low-dose Cyclophosphamide and Dexamethasone
NCT04392037 · ClinicalTrials.gov ↗ · Multiple Myeloma
Phase 2 Active, closed Amsterdam UMC, location VUmc Netherlands
Iberdomide (Cc220) Maintenance After Asct in Newly Diagnosed MM Patients
NCT04564703 · ClinicalTrials.gov ↗ · Multiple Myeloma
Phase 2 Active, closed Stichting European Myeloma Network France, Italy, Netherlands
A Multi-center Open-label Phase 2 Study of Ixazomib, Iberdomide and Dexamethasone in Elderly Patients With Multiple Myeloma at First Relapse."
NCT04998786 · ClinicalTrials.gov ↗ · Multiple Myeloma at First Relapse
Phase 2 Active, closed Nantes University Hospital France
Iberdomide-dexamethasone Alone or in Combination With Standard MM Treatment Regimens in Transplant Ineligible Newly Diagnosed Patients.
NCT05527340 · ClinicalTrials.gov ↗ · Multiple Myeloma
Phase 2 Active, closed PETHEMA Foundation Spain
A Study to Determine Dose, Safety, Tolerability and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Subjects With Multiple Myeloma
NCT02773030 · Multiple Myeloma
Phase 1/2 Active, closed Celgene UK, USA, Germany, France, Spain, Italy, Netherlands, Canada, Japan, Australia, Israel
Study of Safety and Efficacy of Iberdomide (CC-220) and CC-99282 Combined With R-CHOP to Treat Lymphoma
NCT04884035 · Lymphoma, B-Cell
Phase 1 Active, closed Celgene USA, Spain, Poland, South Korea, Taiwan, Australia
A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab or Glofitamab in Combination With CC-220 and/or CC-99282 in Participants With B-Cell Non-Hodgkin Lymphoma
NCT05169515 · Non-Hodgkin Lymphoma
Phase 1 Active, closed Hoffmann-La Roche UK, USA, Spain, Italy, Israel
A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135) and Iberdomide in Patients With Relapsed or Refractory Multiple Myeloma (MagnetisMM-30)
NCT06215118 · Multiple Myeloma
Phase 1 Active, closed Pfizer USA, Canada, Australia

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Iberdomide

7 conditions
Multiple Myeloma15Newly Diagnosed Multiple Myeloma2Non-Hodgkin Lymphoma1Lymphoma, B-Cell1Multiple Myeloma at First Relapse1Myeloma1Refractory Multiple Myeloma1
05

Related compounds

06

Questions about Iberdomide trials

How many clinical trials are testing Iberdomide?

20 current trials in our USA, Israel, Spain, Australia, France, Canada, Netherlands, UK, Germany, Italy, Japan, Poland, South Korea, Austria, Norway, Taiwan, India, China, Belgium, Sweden, Denmark, Czechia, Portugal, Turkey, Brazil, Mexico, Ireland, Switzerland and Singapore registers name Iberdomide (also registered as CC-220) as a drug or biological intervention, as of the registry sync on 10 November 2026. Completed and withdrawn studies are not counted.

Are Iberdomide trials recruiting patients?

Yes. 8 of the 20 trials are recruiting: 3 with sites in USA, 4 with sites in Israel, 2 with sites in Spain, 3 with sites in Australia, 2 with sites in France, 3 with sites in Canada, 1 with sites in Netherlands, 1 with sites in UK, 1 with sites in Germany, 2 with sites in Japan, 1 with sites in Poland, 1 with sites in South Korea and 2 with sites in Norway. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Iberdomide clinical trials?

Celgene (3), AbbVie (2), Hoffmann-La Roche (2) and PETHEMA Foundation (2), among 14 lead sponsors in total. The number in brackets is how many trials each organisation leads.

Are there Iberdomide clinical trials in Ireland?

Yes. 1 trial in our Ireland register (ClinicalTrials.gov). Some may be the same study registered in both. See the Irish clinical trials register for sites and contacts.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Iberdomide works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Iberdomide works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Iberdomide (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 10 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.