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Compound · clinical trials

Belantamab mafodotin

Also listed in trial records as Blenrep
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 16 trials in our USA, China, UK, Ireland and India registers that name Belantamab mafodotin as an intervention. Synced 24 Sep 2026
16Trials tracked
6Recruiting now
3Lead sponsors
5Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards

Belantamab mafodotin is named as a drug or biological intervention in 16 clinical trials in our USA, China, UK, Ireland and India trial registers, 6 of which are recruiting. Lead sponsors include GlaxoSmithKline (14), Karyopharm Therapeutics Inc (1) and Sanofi (1). Registered phases: Phase 1/2, Phase 3, Phase 2 and Phase 1. Conditions studied include Multiple Myeloma; Newly Diagnosed Multiple Myeloma; Amyloidosis.

01

Clinical trials of Belantamab mafodotin

16 trials
NCT IDStudyPhaseStatusLead sponsorRegister
NCT06679101 A Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM) (ClinicalTrials.gov ↗)
Multiple Myeloma, Newly Diagnosed Multiple Myeloma
Phase 3 Recruiting GlaxoSmithKline Ireland, UK, USA, India, China
NCT07224672 A Study to Evaluate the Efficacy and Safety of Belantamab Mafodotin in Combination With Cyclophosphamide, Bortezomib, and Dexamethasone in Adult Participants With Newly Diagnosed Amyloid Light Chain (AL) Amyloidosis (ClinicalTrials.gov ↗)
Amyloidosis
Phase 2 Recruiting GlaxoSmithKline USA
NCT07227311 A Study to Evaluate the Efficacy and Safety of Belantamab Mafodotin in Combination With Standard of Care in Participants With Relapsed-Refractory Multiple Myeloma (RRMM) (ClinicalTrials.gov ↗)
Multiple Myeloma
Phase 2 Recruiting GlaxoSmithKline USA
NCT02343042 Selinexor and Backbone Treatments of Multiple Myeloma Patients (ClinicalTrials.gov ↗)
Multiple Myeloma
Phase 1/2 Recruiting Karyopharm Therapeutics Inc USA
NCT04643002 Isatuximab in Combination With Novel Agents in RRMM - Master Protocol (ClinicalTrials.gov ↗)
Plasma Cell Myeloma Refractory
Phase 1/2 Recruiting Sanofi USA
NCT05714839 A Study to Investigate the Safety and Efficacy of Belantamab for the Treatment of Multiple Myeloma When Used as Monotherapy and in Combination Treatments (ClinicalTrials.gov ↗)
Multiple Myeloma
Phase 1/2 Recruiting GlaxoSmithKline UK, USA, China
NCT04162210 Study of Single Agent Belantamab Mafodotin Versus Pomalidomide Plus Low-dose Dexamethasone (Pom/Dex) in Participants With Relapsed/Refractory Multiple Myeloma (RRMM) (ClinicalTrials.gov ↗)
Multiple Myeloma
Phase 3 Active, closed GlaxoSmithKline UK, USA, China
NCT04246047 Evaluation of Efficacy and Safety of Belantamab Mafodotin, Bortezomib and Dexamethasone Versus Daratumumab, Bortezomib and Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma (ClinicalTrials.gov ↗)
Multiple Myeloma
Phase 3 Active, closed GlaxoSmithKline USA, China
NCT04484623 Belantamab Mafodotin Plus Pomalidomide and Dexamethasone (Pd) Versus Bortezomib Plus Pd in Relapsed/Refractory Multiple Myeloma (ClinicalTrials.gov ↗)
Multiple Myeloma
Phase 3 Active, closed GlaxoSmithKline UK, USA, China
NCT06868654 China Subpopulation: Evaluation of Efficacy and Safety of Belantamab Mafodotin, Bortezomib and Dexamethasone Versus Daratumumab, Bortezomib and Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma (ClinicalTrials.gov ↗)
Multiple Myeloma
Phase 3 Active, closed GlaxoSmithKline China
NCT04126200 Platform Study of Belantamab Mafodotin as Monotherapy and in Combination With Anti-cancer Treatments in Participants With Relapsed/Refractory Multiple Myeloma (RRMM) (ClinicalTrials.gov ↗)
Multiple Myeloma
Phase 1/2 Active, closed GlaxoSmithKline USA
NCT07084896 Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Nirogacestat in Participants With RRMM (ClinicalTrials.gov ↗)
Multiple Myeloma
Phase 1/2 Active, closed GlaxoSmithKline USA
NCT07150091 Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Nirogacestat, Lenalidomide, and Dexamethasone in Participants With RRMM (ClinicalTrials.gov ↗)
Multiple Myeloma
Phase 1/2 Active, closed GlaxoSmithKline USA
NCT07217119 Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Feladilimab (GSK3359609) in Participants With RRMM (ClinicalTrials.gov ↗)
Multiple Myeloma
Phase 1/2 Active, closed GlaxoSmithKline USA
NCT07217184 Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Isatuximab in Participants With RRMM (ClinicalTrials.gov ↗)
Multiple Myeloma
Phase 1/2 Active, closed GlaxoSmithKline USA
NCT04091126 Study of Belantamab Mafodotin Plus Standard of Care (SoC) in Newly Diagnosed Multiple Myeloma (ClinicalTrials.gov ↗)
Multiple Myeloma
Phase 1 Active, closed GlaxoSmithKline UK, USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied

4 conditions
Condition (as registered)Trials
Multiple Myeloma14
Newly Diagnosed Multiple Myeloma1
Amyloidosis1
Plasma Cell Myeloma Refractory1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
GlaxoSmithKline14
Karyopharm Therapeutics Inc1
Sanofi1
04

Trials by country register

A trial with sites in more than one country appears in each of those registers.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Belantamab mafodotin works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Belantamab mafodotin (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 24 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.