Sponsor · clinical trials

Amsterdam UMC, location VUmc clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine — current trials in our Netherlands, Germany, Denmark, Poland, Belgium, Portugal, Spain and Australia registers with Amsterdam UMC, location VUmc as lead sponsor. Synced 13 Nov 2026

61Current trials

42Recruiting now

12Drugs in these trials

8Trial registers

Maintained by Sreepriya Prasannan

MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany

Compiled from ClinicalTrials.gov and CTIS registry records · Synced 13 Nov 2026 · Editorial standards

At a glance

Amsterdam UMC, location VUmc is the lead sponsor of 61 current clinical trials in our Netherlands, Germany, Denmark, Poland, Belgium, Portugal, Spain and Australia registers. 42 are recruiting patients now. The most common phase is Not applicable. The drugs named most often in its trials are Pembrolizumab, B) and Folfirinox. The most-studied condition is Breast Cancer.

ClinicalTrials.gov trials by status

Recruiting4269%
Not yet open813%
Active, closed915%
By invitation23%

Trials by phase

Not applicable3354%
Observational1321%
Phase 458%
Phase 247%
Phase 335%
Phase 2/323%
Phase 1/212%

Clinical trials sponsored by Amsterdam UMC, location VUmc

61 on ClinicalTrials.gov

Study	Phase	Status	Start	Registers
Tacrolimus as Prophylaxis of Post-ERCP Pancreatitis NCT07781722 · ClinicalTrials.gov ↗ · Post-ERCP Pancreatitis Drug: Tacrolimus	Phase 4	Recruiting	2026-10	Netherlands
Developing Trustworthy Artificial Intelligence (AI)-Driven Tools to Predict Vascular Disease Risk and Progression NCT06206369 · ClinicalTrials.gov ↗ · Aneurysm Abdominal, Peripheral Arterial Disease	Observational	Recruiting	2023-10	Germany, Netherlands, Portugal
Postoperative Re-irradiaTion With and Without HYPERthermia, or Surgery Only: Toxicity, Quality of Life and Survival in Patients With Locoregional Recurrent Breast Cancer NCT06452485 · ClinicalTrials.gov ↗ · Locoregional Recurrence, Breast Cancer, Re-irradiation	Observational	Recruiting	2024-02	Netherlands
COLLISION RELAPSE Trial NCT05861505 · ClinicalTrials.gov ↗ · Colorectal Cancer, Liver Metastases, Liver Metastasis Colon Cancer Drug: B)	Phase 3	Recruiting	2023-04	Netherlands
Extensive Resection of Malignant Brain Tumors Using Advanced Imaging Techniques NCT06623565 · ClinicalTrials.gov ↗ · Glioblastoma, Astrocytoma, IDH-Mutant, Grade 4	Not applicable	Recruiting	2024-04	Netherlands
Brain Stimulation in Long COVID NCT07278206 · ClinicalTrials.gov ↗ · Long COVID, PASC Post Acute Sequelae of COVID 19, Post COVID-19 Condition (PCC)	Not applicable	Recruiting	2025-11	Netherlands
YoPA - A Youth-centred Participatory Action NCT06181162 · ClinicalTrials.gov ↗ · Physical Activity, Health Promotion, Sleep	Not applicable	Recruiting	2023-11	Netherlands, Denmark
The Microcirculation, Dialysis Modality and Sequestered Salt NCT06327750 · End-stage Renal Disease	Not applicable	Recruiting	2026-06	Netherlands
Trilateral Retinoblastoma: Incidence and Outcomes NCT06367530 · ClinicalTrials.gov ↗ · Trilateral Retinoblastoma, Retinoblastoma	Observational	Recruiting	2024-01	Netherlands
Neoadjuvant Triple Therapy for (Borderline) Resectable Pancreatic Cancer (PREOPANC-5) NCT06384560 · ClinicalTrials.gov ↗ · Localized Pancreatic Adenocarcinoma, Borderline Resectable Pancreatic Adenocarcinoma, Resectable Pancreatic Adenocarcinoma Drugs: Folfirinox, Pembrolizumab	Phase 1/2	Recruiting	2024-09	Netherlands
Back on Track: Evaluation of an Occupational Reintegration Protocol for Employees With Musculoskeletal Disorders NCT07793526 · ClinicalTrials.gov ↗ · Musculoskeletal Disorders (MSDs)	Observational	Recruiting	2025-07	Netherlands
ORthosis vs No Orthosis After Surgically Treated Traumatic Thoracolumbar Fractures NCT03097081 · ClinicalTrials.gov ↗ · Spine Fracture, Orthosis, Traumatic Fracture	Not applicable	Recruiting	2016-11	Netherlands
Prevention of Opioid-induced Constipation in Patients With Advanced Cancer NCT05216328 · ClinicalTrials.gov ↗ · Constipation, Opioid-Induced	Phase 4	Recruiting	2022-12	Netherlands
TMS for Exposure Therapy Resistant OCD NCT05331937 · ClinicalTrials.gov ↗ · 1 Hz Real rTMS to the Pre-SMA, 1 Hz Sham rTMS to the Pre-SMA	Phase 3	Recruiting	2022-05	Netherlands
Registry of Patients That Have Undergone ICA or PCI NCT04815928 · ClinicalTrials.gov ↗ · Coronary Artery Disease	Observational	Recruiting	2020-07	Netherlands
Single-dose Preoperative Partial Breast Irradiation in Low-risk Breast Cancer Patients NCT05350722 · ClinicalTrials.gov ↗ · Breast Cancer	Not applicable	Recruiting	2022-08	Netherlands, Australia
A Clinical Imaging Study of the Changes in [18F]F-AraG Uptake Following Anti-PD-1 Therapy in Non-small Cell Lung Cancer NCT05701176 · ClinicalTrials.gov ↗ · Advanced Stage Non-small Cell Lung Cancer	Not applicable	Recruiting	2022-11	Netherlands
Appropriate Use of Blood Cultures in the Emergency Department Through Machine Learning NCT06163781 · ClinicalTrials.gov ↗ · Artificial Intelligence, Machine Learning, Microbiology	Not applicable	Recruiting	2024-02	Netherlands
Non-inferiority Study of Rituximab Compared to Ocrelizumab in Relapsing MS NCT05834855 · Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Demyelinating Autoimmune Diseases, CNS Drugs: Rituximab, Ruxience, Truxima	Phase 3	Recruiting	2023-04	Netherlands
Prior CABG Patients Evaluated for Saphenous VeIn grAft DysfUnction and Progression of Coronary arTery Disease NCT04772768 · ClinicalTrials.gov ↗ · Recurrent Angina After Coronary Artery Bypass Graft, Graft Failure, Coronary Artery Disease Progression	Observational	Recruiting	2019-08	Netherlands
Multiple Sclerosis Treatment With Autologous Hematopoietic Stem Cell Transplantation in the Netherlands NCT06567197 · ClinicalTrials.gov ↗ · Multiple Sclerosis, Relapsing-Remitting	Observational	Recruiting	2023-08	Netherlands
Assessment of PET Tracers to Evaluate T Cell Change and Activation in Relation to Immunotherapy Treatment Response in Non-Small Cell Lung Cancer NCT06457789 · ClinicalTrials.gov ↗ · NSCLC	Not applicable	Recruiting	2024-12	Netherlands
Power2Walk: The Impact of Functional Power Training on Participation and Activity in Children With Cerebral Palsy. NCT06640894 · ClinicalTrials.gov ↗ · Cerebral Palsy, Spastic	Not applicable	Recruiting	2024-07	Netherlands
Right Ventricular Compensation With Sotatercept: A Prospective Single Arm Open Label Phase 4 Study to Evaluate the Effects of Sotatercept on Right Ventricular Function in Pulmonary Arterial Hypertension (RECOMPENSE) NCT06658522 · ClinicalTrials.gov ↗ · Pulmonary Arterial Hypertension PAH, Pulmonary Arterial Hypertension WHO Group I, Pulmonary Arterial Hypertension Drug: Sotatercept	Phase 4	Recruiting	2025-05	Netherlands
The Cost-effectiveness of Hysterosalpingography Versus Hysterosalpingo-foam Sonography During Fertility Work-up NCT05882188 · ClinicalTrials.gov ↗ · Infertility	Not applicable	Recruiting	2023-09	Netherlands
Use of Mechanical Left ventricuLar Unloading in Complex Higher-risk Indicated Procedures NCT07380217 · High-risk PCI, Coronary Artery Disease Risk High	Not applicable	Recruiting	2024-01	Netherlands
COLDFIRE-III Trial: Efficacy of Irreversible Electroporation and Stereotactic Body Radiotherapy for Perivascular and Peribiliary Colorectal Liver Metastases NCT06185556 · ClinicalTrials.gov ↗ · Colorectal Cancer, Liver Metastases, Liver Metastasis Colon Cancer	Phase 2/3	Recruiting	2024-08	Netherlands
Effect of Functional Power Training on Calf Muscle Length and Strength in Children With Spastic Paresis NCT05649930 · ClinicalTrials.gov ↗ · Cerebral Palsy, Spastic	Observational	Recruiting	2022-06	Netherlands
Don't be Late! Postponing Cognitive Decline and Preventing Early Unemployment in People With Multiple Sclerosis NCT06068582 · ClinicalTrials.gov ↗ · Multiple Sclerosis	Not applicable	Recruiting	2023-04	Netherlands
Cue2Walk, Cost-effectiveness of Automated Freezing Detection and Provision of External Cues in Comparison to Usual Care in People With Parkinson's Disease NCT06416345 · ClinicalTrials.gov ↗ · Parkinson Disease	Not applicable	Recruiting	2025-08	Netherlands
DiEtary Sodium Intake Effects on Ertugliflozin-induced Changes in GFR, reNal Oxygenation and Systemic Hemodynamics: the DESIGN Study, a Randomized, Placebo-controlled, Cross-over Study With Ertugliflozin in People With Type 2 Diabetes NCT06983054 · ClinicalTrials.gov ↗ · Type 2 Diabetes	Phase 4	Recruiting	2023-07	Netherlands
Dutch-Depression Outcome Trial Comparing 5 Day Multi Daily Neuronavigated Theta Burst Sessions With 6 Weeks rTMS NCT05900271 · ClinicalTrials.gov ↗ · Treatment Resistant Depression	Not applicable	Recruiting	2023-11	Netherlands
P4O2 ILD Extension NCT06644144 · ClinicalTrials.gov ↗ · Interstitial Lung Disease, Pulmonary Fibrosis, Interstitial Lung Fibrosis	Observational	Recruiting	2024-11	Netherlands
Metformin as a Metabolic Intervention in Oesophageal Adenocarcinomas to Improve Response to Neoadjuvant Chemoradiotherapy NCT06687876 · ClinicalTrials.gov ↗ · Oesophageal Adenocarcinoma, Tumor Microenvironment Drug: Metformin	Phase 2	Recruiting	2025-03	Netherlands
Preoperative Partial Breast Reirradiation and Repeat Breast-conserving Surgery in Patients With Recurrent Breast Cancer: the REPEAT Trial NCT06640881 · ClinicalTrials.gov ↗ · Recurrent Breast Carcinoma, Ipsilateral Recurrence	Phase 2	Recruiting	2025-01	Netherlands
Does Increasing the Compression Pause From 3 to 5 Seconds in Mechanical Compression Devices Increase Ventilation Success Rate and Return of Spontaneous Circulation? NCT06824961 · ClinicalTrials.gov ↗ · Cardiac Arrest (CA)	Not applicable	Recruiting	2026-01	Netherlands
Irreversible Electroporation (IRE) for Treating Recurrent Pelvic Tumors (PELFIRE Study) NCT07782164 · ClinicalTrials.gov ↗ · Colorectal Carcinoma, Renal Cancer, Bladder Cancer	Observational	Recruiting	2025-04	Netherlands
BPA in CTEPD Without PH NCT06090838 · ClinicalTrials.gov ↗ · Chronic Thromboembolic Disease	Not applicable	Recruiting	2023-06	Netherlands
FeelFit: High-intensity Interval Training to Improve Self-reported Physical Fitness in Brain Tumor Patients NCT06282562 · ClinicalTrials.gov ↗ · Brain Tumor, Primary, Exercise	Not applicable	Recruiting	2024-01	Netherlands
Neoadjuvant Gemcitabine and Cisplatin in Combination With Perioperative Pembrolizumab Versus Upfront Surgery for Patients With Primary Resectable and Borderline Resectable Perihilar and Distal Cholangiocarcinoma NCT06923475 · ClinicalTrials.gov ↗ · Extrahepatic Cholangiocarcinoma, Perihilar Cholangiocarcinoma, Distal Cholangiocarcinoma Drugs: Gemcitabine/Cisplatin, Pembrolizumab	Phase 2/3	Recruiting	2026-04	Netherlands
Adaptive Anastomosis for Anterior Resection in Sigmoid and Proximal Rectal Cancer or Premalignant Lesions NCT07056374 · ClinicalTrials.gov ↗ · Rectal Cancer, Sigmoid Cancer, Premalignant Lesion	Observational	Recruiting	2025-03	Netherlands
Improved Prescribing for Older Nursing Home Patients NCT06731361 · ClinicalTrials.gov ↗ · Nursing Home Residents, Older People, Prescribing	Not applicable	Recruiting	2024-09	Netherlands
VACStent Use for the Treatment of Anastomotic Leakage Following coloREctal Surgery NCT07631702 · ClinicalTrials.gov ↗ · Colorectal Surgery, Anastomotic Leak Rectum, Endoscopy, Digestive System	Not applicable	Not yet open	2026-07	Netherlands
Endoscopic (EID) Versus Surgical (TAMIS) Local Excision for Early Stage Rectal Cancer NCT07846046 · ClinicalTrials.gov ↗ · Rectal Cancer Stage I	Not applicable	Not yet open	2026-09	Netherlands
Unloading in Heart Failure Cardiogenic Shock NCT05064202 · ClinicalTrials.gov ↗ · Cardiogenic Shock	Not applicable	Not yet open	2023-10	Netherlands
Transgender Analysis of Nephrological Studies Focused on Renal Metrics NCT07542964 · ClinicalTrials.gov ↗ · Kidney Disease, Kidney Injury, Transgender Individuals	Observational	Not yet open	2026-09	Netherlands
Evaluating Healthcare Professionals' Satisfaction and Stress Mitigation Using Virtual Reality Intervention in Surgical Ward NCT07155681 · ClinicalTrials.gov ↗ · Stress, Stress (Psychology)	Not applicable	Not yet open	2025-11	Germany, Denmark
Colorectal Pulmonary Metastases: Pulmonary Metastasectomy Versus Stereotactic Ablative Radiotherapy NCT05808790 · ClinicalTrials.gov ↗ · Lung Metastases, Colorectal Cancer Metastatic	Not applicable	Not yet open	2024-01	Netherlands
Validating Digital Biomarkers to Detect Disease Activity and Disease Progression in Multiple Sclerosis NCT06627465 · Multiple Sclerosis	Observational	Not yet open	2024-10	Netherlands
Standardizing Right Hemicolectomy for Colon Cancer NCT04889456 · ClinicalTrials.gov ↗ · Colonic Carcinoma, Laparoscopic Right Hemicolectomy, Standardisation	Not applicable	Not yet open	2021-07	Netherlands
Vital@Work: an Intervention for Prevention of Mental Health Complaints at Work NCT06445101 · ClinicalTrials.gov ↗ · Stress	Not applicable	By invitation	2024-04	Netherlands
B-challenged: Co-creating Physical and Social Environments to Promote Children's Active Outdoor Play NCT07136376 · ClinicalTrials.gov ↗ · Active Outdoor Play and Related Healthy Dietary Behaviours	Not applicable	By invitation	2024-09	Germany, Spain, Netherlands, Denmark, Poland
Saracatinib Trial TO Prevent FOP NCT04307953 · ClinicalTrials.gov ↗ · Fibrodysplasia Ossificans Progressiva	Phase 2	Active, closed	2020-08	Germany, Netherlands
Brief-intensive CBT Versus Once-weekly CBT in Anxiety-related Disorders NCT05942391 · ClinicalTrials.gov ↗ · Anxiety Disorders, Obsessive-Compulsive Disorder, Posttraumatic Stress Disorder	Not applicable	Active, closed	2024-04	Netherlands
B Cell Tailored Ocrelizumab Versus Standard Ocrelizumab in Relapsing Remitting Multiple Sclerosis NCT05296161 · ClinicalTrials.gov ↗ · Multiple Sclerosis, Relapsing-Remitting Drug: Ocrelizumab	Phase 4	Active, closed	2022-04	Netherlands
Integration of Whole-Genome Sequencing PrOfiles and ImmuNe StATus in Cancer NCT07796594 · ClinicalTrials.gov ↗ · Melanoma, Pancreas Cancer	Not applicable	Active, closed	2023-07	Netherlands
PeRcutaneous cOronary Intervention of Native Coronary arTery Versus Venous Bypass Graft in Patients With Prior CABG NCT03805048 · ClinicalTrials.gov ↗ · Coronary Artery Disease	Not applicable	Active, closed	2019-01	Germany, Netherlands, Belgium, Poland
High Power Short Duration Radiofrequency Ablation of Atrial Fibrillation Using the QDOT MICRO™ Catheter NCT06846502 · ClinicalTrials.gov ↗ · Atrial Fibrillation (AF)	Not applicable	Active, closed	2023-06	Netherlands
Dynamic and Test-retest Whole Body [18F]FES PET Imaging in Patients With Metastatic ER+ Breast Cancer NCT05088785 · ClinicalTrials.gov ↗ · Breast Cancer	Not applicable	Active, closed	2021-10	Netherlands
Iberdomide Combined With Low-dose Cyclophosphamide and Dexamethasone NCT04392037 · ClinicalTrials.gov ↗ · Multiple Myeloma Drug: Iberdomide	Phase 2	Active, closed	2021-02	Netherlands
[18F]F-AraG PET Imaging to Visualize Tumor Infiltrating T-cell Activation in Non-small Cell Lung Cancer. NCT05157659 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer	Not applicable	Active, closed	2021-12	Netherlands

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Titles and statuses are copied from the registry as published.

Drugs in Amsterdam UMC, location VUmc trials

12 compounds

Drugs and biologicals named as interventions in these trials, with the number of this sponsor's trials that name each one. Placebos and generic comparators are excluded.

Pembrolizumab2 B)1 Folfirinox1 Gemcitabine/Cisplatin1 Iberdomide1 Metformin1 Ocrelizumab1 Rituximab1 Ruxience1 Sotatercept1 Tacrolimus1 Truxima1

Conditions in Amsterdam UMC, location VUmc trials

114 conditions

Breast Cancer3 Colorectal Cancer3Multiple Sclerosis, Relapsing-Remitting3Multiple Sclerosis3 Coronary Artery Disease2 Stress2 Liver Metastases2Liver Metastasis Colon Cancer2Cerebral Palsy, Spastic2Fibrodysplasia Ossificans Progressiva1Stress (Psychology)1Aneurysm Abdominal1Peripheral Arterial Disease1Active Outdoor Play and Related Healthy Dietary Behaviours1Post-ERCP Pancreatitis1Anxiety Disorders1 Obsessive-Compulsive Disorder1Posttraumatic Stress Disorder1Hypochondriasis1Locoregional Recurrence1Re-irradiation1Hyperthermia1Chemotherapy Effect1 Glioblastoma1

By trial register

Register	Trials	Recruiting
Clinical trials in Netherlands	60	42
Clinical trials in Germany	5	1
Clinical trials in Denmark	3	1
Clinical trials in Poland	2	0
Clinical trials in Belgium	1	0
Clinical trials in Portugal	1	1
Clinical trials in Spain	1	0
Clinical trials in Australia	1	1

A trial with sites in more than one country appears in each of those registers.

Other sponsors in Breast Cancer

Sponsor	Trials
Fudan University	50
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University	21
AstraZeneca	18
Second Affiliated Hospital, Zhejiang University, School of Medicine	18
University Health Network, Toronto	16
Institut du Cancer de Montpellier - Val d'Aurelle	16
Sunnybrook Health Sciences Centre	15
Shengjing Hospital	15
European Institute of Oncology	14
Pfizer	12

Sponsors with the most current trials registered for this condition.

Questions about Amsterdam UMC, location VUmc trials

How many clinical trials does Amsterdam UMC, location VUmc sponsor?

Amsterdam UMC, location VUmc is the lead sponsor of 61 current trials on ClinicalTrials.gov in our Netherlands, Germany, Denmark, Poland, Belgium, Portugal, Spain and Australia registers, as of the registry sync on 13 November 2026. Completed and withdrawn studies are not counted.

Are Amsterdam UMC, location VUmc trials recruiting?

Yes. 42 of its 61 ClinicalTrials.gov trials are recruiting. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Which drugs is Amsterdam UMC, location VUmc testing?

Its current trials name 12 drugs and biologicals as interventions. The most frequent are Pembrolizumab (2), B) (1), Folfirinox (1), Gemcitabine/Cisplatin (1) and Iberdomide (1). The number in brackets is how many of its trials name each drug.

Where does this information come from?

Every trial, status, phase and condition on this page is copied from public ClinicalTrials.gov and EU CTIS records by a daily sync, grouped by the sponsor name each registry records. It says nothing about the organisation beyond its registered trials, and it is not medical advice.

How this page is built

Everything on this page is copied from public registry records — it is not written from memory, and nothing here describes the organisation beyond its registered trials. Each trial links to its own record so you can check it yourself.

ClinicalTrials.gov (U.S. National Library of Medicine) ↗ Trial IDs, titles, lead sponsor, phase, overall status, start date, conditions and intervention names
EU Clinical Trials Information System (CTIS) ↗ EU trial numbers, titles, sponsor, phase, status, therapeutic area and member-state countries

This page is built automatically: a daily sync job reads the registry records behind our trial registers and groups every current trial by its lead sponsor name, ignoring legal-form suffixes such as Inc. or Ltd. A small, hand-checked list joins the same organisation's different registry names (for example its EU legal entity). There is no AI drafting and no per-sponsor editorial pass. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The the registries data on this page was last retrieved on 13 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.