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Compound · clinical trials

Metformin clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 31 trials in our China, USA, UK, India and Ireland registers that name Metformin as an intervention. Synced 25 Sep 2026
31Current trials
14Recruiting now
25Lead sponsors
5Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

Metformin is named as an intervention in 31 current clinical trials in our China, USA, UK, India and Ireland registers. 14 are recruiting patients now. The most common phase is Not applicable. The sponsor with the most trials is Peking University Third Hospital (3). The most-studied condition is Obesity.

Metformin also has an approved-drug profile on this site (FDA label data): Glucophage (Metformin) →

Trials by status

  • Recruiting1445%
  • Not yet open929%
  • Active, closed619%
  • By invitation26%

Trials by phase

  • Not applicable929%
  • Phase 4723%
  • Phase 1619%
  • Phase 2310%
  • Phase 3310%
  • Phase 1/226%
  • Phase 2/313%
01

Clinical trials of Metformin

31 trials
StudyPhaseStatusLead sponsorRegisters
Liraglutide Treatment in Obese Infertile PCOS Women
NCT06742710 · ClinicalTrials.gov ↗ · PCOS, Obesity, Infertility
Phase 4 Recruiting Peking University Third Hospital China
Metformin in Post Chronic Pancreatitis Diabetes Mellitus
NCT06937294 · ClinicalTrials.gov ↗ · Chronic Pancreatitis
Phase 4 Recruiting Changhai Hospital China
Cofrogliptin Once Every 2 Weeks as Add-on Therapy to Metformin and Dapagliflozin Versus Daily Linagliptin in Patients With Type 2 Diabetes.
NCT07019012 · ClinicalTrials.gov ↗ · T2DM
Phase 4 Recruiting Huazhong University of Science and Technology China
Efficacy and Safety of the Met+SGLT-2i+GLP-1RA in Patients With Type 2 Diabetes With Poor Glycemic Control
NCT07244003 · ClinicalTrials.gov ↗ · T2DM (Type 2 Diabetes Mellitus)
Phase 4 Recruiting Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. China
Metformin Alleviates Abnormal Glucose Metabolism Induced by Statins in Schizophrenia Patients
NCT07045142 · ClinicalTrials.gov ↗ · Schizophrenia
Phase 3 Recruiting Central South University China
Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation
NCT07092618 · ClinicalTrials.gov ↗ · Longevity, GLP-1, Geroscience
Phase 2/3 Recruiting AgelessRx USA
Acupuncture or Metformin for Insulin Resistance in Women With PCOS
NCT02647827 · ClinicalTrials.gov ↗ · Polycystic Ovary Syndrome, Insulin Resistance, Hyperandrogenism
Phase 2 Recruiting Karolinska Institutet China
A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer
NCT03424005 · Metastatic Breast Cancer
Phase 1/2 Recruiting Hoffmann-La Roche UK, USA
First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors
NCT05768139 · ClinicalTrials.gov ↗ · Breast Cancer, Solid Tumors, Adult
Phase 1/2 Recruiting Eli Lilly and Company Ireland, USA
Metformin Inhibits DNMT3A Clonal Hematopoiesis in Acute Leukemia
NCT07188740 · ClinicalTrials.gov ↗ · DNMT3A Gene Mutation
Phase 1 Recruiting Institute of Hematology & Blood Diseases Hospital, China China
A Study of LY4515100 in Healthy Participants
NCT07339722 · ClinicalTrials.gov ↗ · Healthy
Phase 1 Recruiting Eli Lilly and Company USA
Efficacy and Safety Comparison of Cofrogliptin Add-on Versus Metformin Dose-escalation in Type 2 Diabetes Patients Inadequately Controlled With SGLT-2 Inhibitors Plus Low-Dose Metformin:A Multicenter, Open-Label Trial
NCT06863532 · ClinicalTrials.gov ↗ · Type 2 Diabetes
Not applicable Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine China
Acute Portal Pressure Reduction by Metformin and Carvedilol Compared to Carvedilol Alone in Cirrhosis.
NCT07108075 · Liver Cirrhosis
Not applicable Recruiting Institute of Liver and Biliary Sciences, India India
Semaglutide and Tirzepatide for Genetic Aging Delay in Adults With Obesity
NCT07293325 · ClinicalTrials.gov ↗ · Adults With Simple Obesity
Not applicable Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine China
Henagliflozin on Liver Fibrosis in Patients with MASLD and T2DM
NCT06762223 · ClinicalTrials.gov ↗ · Metabolic Dysfunction-associated Steatotic Liver Disease, Type 2 Diabetes Mellitus
Phase 4 Not yet open Xiqiao Zhou China
The Effect of Semaglutide on Bone Health
NCT07165158 · ClinicalTrials.gov ↗ · Osteoporosis, Osteoporosis Fracture, T2DM
Phase 4 Not yet open The First Affiliated Hospital of Xiamen University China
Influence of HDM1005 on Gastric Emptying and Pharmacokinetics of Metformin, Atorvastatin, Warfarin, and Digoxin
NCT07502001 · ClinicalTrials.gov ↗ · Overweight, Obesity
Phase 1 Not yet open Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. China
Phase 1 Study in Healthy Adults to See How Sevabertinib Changes Metformin Levels in the Body
NCT07753252 · ClinicalTrials.gov ↗ · Healthy Participants
Phase 1 Not yet open Bayer USA
Effects of GLP-1RAs on Reproductive Outcomes in PCOS and Obesity
NCT06775093 · ClinicalTrials.gov ↗ · Polycystic Ovary Syndrome, Obesity, Infertility, Female
Not applicable Not yet open Peking University Third Hospital China
Effects of Cofrogliptin on Beta-Cell Function in LADA Patients
NCT07460336 · ClinicalTrials.gov ↗ · Latent Autoimmune Diabetes in Adults (LADA)
Not applicable Not yet open Second Xiangya Hospital of Central South University China
Effects of GLP-1RAs on Fertility Outcomes in Obese Women With PCOS
NCT07687667 · ClinicalTrials.gov ↗ · Polycystic Ovary Syndrome (PCOS), Obesity, Infertility, Female
Not applicable Not yet open Peking University Third Hospital China
Efficacy and Safety of Hebenrun in Patients With Type 2 Diabetes
NCT07768280 · ClinicalTrials.gov ↗ · Type 2 Diabetes Mellitus
Not applicable Not yet open Jiangxi University of Traditional Chinese Medicine China
Metformin-Dapagliflozin Effects on IGF-1 in Male T2DM With MASLD
NCT07778719 · ClinicalTrials.gov ↗ · Type 2 Diabetes, Metabolic Dysfunction-Associated Steatotic Liver Disease
Not applicable Not yet open The 95th Hospital of Putian๏ผŒPutian, Fujian, China China
Assessing Incretin Therapy for Cardiovascular Risk Reduction and Diabetes Remission( ITCRDR Study)
NCT06959784 · ClinicalTrials.gov ↗ · Diabetes Mellitus, Cardiovascular Diseases, Cerebrovascular Disease
Phase 4 By invitation China-Japan Friendship Hospital China
Study of Time-restricted Eating (TRE) to Clinical Pregnancy Rate in PCOS Women With Glucose Metabolism Disorder Via IVF/ICSI
NCT06666933 · ClinicalTrials.gov ↗ · PCOS, Glucose Metabolism Disorder, IVF Outcome
Not applicable By invitation RenJi Hospital China
A Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Dulaglutide in Combination Therapy Diabetes Mellitus Type 2 Patients With Metformin
NCT06257966 · ClinicalTrials.gov ↗ · Type2 Diabetes Mellitus
Phase 3 Active, closed Beijing Dongfang Biotech Co., Ltd. China
Combination Gerotherapeutic Interventions for Healthspan Improvement
NCT07475546 · Healthspan Improvement, Aging, Longevity
Phase 3 Active, closed AgelessRx USA
An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer
NCT02365597 · ClinicalTrials.gov ↗ · Urothelial Cancer
Phase 2 Active, closed Janssen Research & Development, LLC UK, USA, India
The Effect of Metformin in Patients With Newly Diagnosed mHSPC
NCT04925063 · ClinicalTrials.gov ↗ · Metastatic Prostate Cancer
Phase 2 Active, closed Sun Yat-sen University China
To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer
NCT03006172 · ClinicalTrials.gov ↗ · Breast Cancer, Solid Tumor
Phase 1 Active, closed Genentech, Inc. UK, USA
Drug-durg Interaction of RAY1225 With Warfarin, Atorvastatin, Metformin and Digoxin
NCT07362030 · ClinicalTrials.gov ↗ · Obesity
Phase 1 Active, closed Guangdong Raynovent Biotech Co., Ltd China

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Metformin

42 conditions
Obesity5Breast Cancer2Aging2Longevity2Infertility, Female2T2DM2Type 2 Diabetes2Type 2 Diabetes Mellitus2Polycystic Ovary Syndrome2PCOS2Solid Tumors, Adult1Metastatic Breast Cancer1
All 42 conditions
Condition (as registered)Trials
Obesity5
Breast Cancer2
Aging2
Longevity2
Infertility, Female2
T2DM2
Type 2 Diabetes2
Type 2 Diabetes Mellitus2
Polycystic Ovary Syndrome2
PCOS2
Solid Tumors, Adult1
Metastatic Breast Cancer1
Solid Tumor1
Urothelial Cancer1
Healthspan Improvement1
Healthy1
GLP-11
Geroscience1
Healthy Participants1
Liver Cirrhosis1
T2DM (Type 2 Diabetes Mellitus)1
Adults With Simple Obesity1
Polycystic Ovary Syndrome (PCOS)1
Type2 Diabetes Mellitus1
Schizophrenia1
DNMT3A Gene Mutation1
Diabetes Mellitus1
Cardiovascular Diseases1
Cerebrovascular Disease1
Osteoporosis1
Osteoporosis Fracture1
Metastatic Prostate Cancer1
Chronic Pancreatitis1
Metabolic Dysfunction-Associated Steatotic Liver Disease1
Overweight1
Infertility1
Metabolic Dysfunction-associated Steatotic Liver Disease1
Glucose Metabolism Disorder1
IVF Outcome1
Latent Autoimmune Diabetes in Adults (LADA)1
Insulin Resistance1
Hyperandrogenism1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Peking University Third Hospital3
Eli Lilly and Company2
AgelessRx2
Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.2
Second Affiliated Hospital, Zhejiang University, School of Medicine2
Hoffmann-La Roche1
Genentech, Inc.1
Janssen Research & Development, LLC1
Bayer1
Institute of Liver and Biliary Sciences, India1
Huazhong University of Science and Technology1
Beijing Dongfang Biotech Co., Ltd.1
Central South University1
Institute of Hematology & Blood Diseases Hospital, China1
China-Japan Friendship Hospital1

+ 10 more sponsors in the trial list above.

04

By country register

RegisterTrialsRecruiting
Clinical trials in China229
Clinical trials in USA84
Clinical trials in UK31
Clinical trials in India21
Clinical trials in Ireland11

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about Metformin trials

How many clinical trials are testing Metformin?

31 current trials in our China, USA, UK, India and Ireland registers name Metformin as a drug or biological intervention, as of the registry sync on 25 September 2026. Completed and withdrawn studies are not counted.

Are Metformin trials recruiting patients?

Yes. 14 of the 31 trials are recruiting: 9 with sites in China, 4 with sites in USA, 1 with sites in UK, 1 with sites in India and 1 with sites in Ireland. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Metformin clinical trials?

Peking University Third Hospital (3), Eli Lilly and Company (2), AgelessRx (2) and Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd (2), among 25 lead sponsors in total. The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Metformin works or whether it is effective, and it is not medical advice.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Metformin works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Metformin (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 25 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.