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Compound · clinical trials

Metformin

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 28 trials in our China, USA, UK, India and Ireland registers that name Metformin as an intervention. Synced 24 Sep 2026
28Trials tracked
13Recruiting now
24Lead sponsors
5Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards

Metformin is named as a drug or biological intervention in 28 clinical trials in our China, USA, UK, India and Ireland trial registers, 13 of which are recruiting. Lead sponsors include Eli Lilly and Company (2), AgelessRx (2) and Second Affiliated Hospital, Zhejiang University, School of Medicine (2). Registered phases: Not applicable, Phase 4, Phase 1, Phase 2, Phase 3, Phase 1/2 and Phase 2/3. Conditions studied include Breast Cancer; Longevity; Aging.

Metformin also has an approved-drug profile on this site (FDA label data): Glucophage (Metformin) →
01

Clinical trials of Metformin

28 trials
NCT IDStudyPhaseStatusLead sponsorRegister
NCT06937294 Metformin in Post Chronic Pancreatitis Diabetes Mellitus (ClinicalTrials.gov ↗)
Chronic Pancreatitis
Phase 4 Recruiting Changhai Hospital China
NCT07019012 Cofrogliptin Once Every 2 Weeks as Add-on Therapy to Metformin and Dapagliflozin Versus Daily Linagliptin in Patients With Type 2 Diabetes. (ClinicalTrials.gov ↗)
T2DM
Phase 4 Recruiting Huazhong University of Science and Technology China
NCT07244003 Efficacy and Safety of the Met+SGLT-2i+GLP-1RA in Patients With Type 2 Diabetes With Poor Glycemic Control (ClinicalTrials.gov ↗)
T2DM (Type 2 Diabetes Mellitus)
Phase 4 Recruiting Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. China
NCT07045142 Metformin Alleviates Abnormal Glucose Metabolism Induced by Statins in Schizophrenia Patients (ClinicalTrials.gov ↗)
Schizophrenia
Phase 3 Recruiting Central South University China
NCT07092618 Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation
Longevity, GLP-1, Geroscience
Phase 2/3 Recruiting AgelessRx USA
NCT02647827 Acupuncture or Metformin for Insulin Resistance in Women With PCOS (ClinicalTrials.gov ↗)
Polycystic Ovary Syndrome, Insulin Resistance, Hyperandrogenism
Phase 2 Recruiting Karolinska Institutet China
NCT03424005 A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer (ClinicalTrials.gov ↗)
Metastatic Breast Cancer
Phase 1/2 Recruiting Hoffmann-La Roche UK, USA
NCT05768139 First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors
Breast Cancer, Solid Tumors, Adult
Phase 1/2 Recruiting Eli Lilly and Company Ireland, USA
NCT07188740 Metformin Inhibits DNMT3A Clonal Hematopoiesis in Acute Leukemia (ClinicalTrials.gov ↗)
DNMT3A Gene Mutation
Phase 1 Recruiting Institute of Hematology & Blood Diseases Hospital, China China
NCT07339722 A Study of LY4515100 in Healthy Participants (ClinicalTrials.gov ↗)
Healthy
Phase 1 Recruiting Eli Lilly and Company USA
NCT06863532 Efficacy and Safety Comparison of Cofrogliptin Add-on Versus Metformin Dose-escalation in Type 2 Diabetes Patients Inadequately Controlled With SGLT-2 Inhibitors Plus Low-Dose Metformin:A Multicenter, Open-Label Trial (ClinicalTrials.gov ↗)
Type 2 Diabetes
Not applicable Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine China
NCT07108075 Acute Portal Pressure Reduction by Metformin and Carvedilol Compared to Carvedilol Alone in Cirrhosis.
Liver Cirrhosis
Not applicable Recruiting Institute of Liver and Biliary Sciences, India India
NCT07293325 Semaglutide and Tirzepatide for Genetic Aging Delay in Adults With Obesity (ClinicalTrials.gov ↗)
Adults With Simple Obesity
Not applicable Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine China
NCT06762223 Henagliflozin on Liver Fibrosis in Patients with MASLD and T2DM (ClinicalTrials.gov ↗)
Metabolic Dysfunction-associated Steatotic Liver Disease, Type 2 Diabetes Mellitus
Phase 4 Not yet open Xiqiao Zhou China
NCT07165158 The Effect of Semaglutide on Bone Health (ClinicalTrials.gov ↗)
Osteoporosis, Osteoporosis Fracture, T2DM
Phase 4 Not yet open The First Affiliated Hospital of Xiamen University China
NCT07753252 Phase 1 Study in Healthy Adults to See How Sevabertinib Changes Metformin Levels in the Body (ClinicalTrials.gov ↗)
Healthy Participants
Phase 1 Not yet open Bayer USA
NCT06775093 Effects of GLP-1RAs on Reproductive Outcomes in PCOS and Obesity (ClinicalTrials.gov ↗)
Polycystic Ovary Syndrome, Obesity, Infertility, Female
Not applicable Not yet open Peking University Third Hospital China
NCT07460336 Effects of Cofrogliptin on Beta-Cell Function in LADA Patients (ClinicalTrials.gov ↗)
Latent Autoimmune Diabetes in Adults (LADA)
Not applicable Not yet open Second Xiangya Hospital of Central South University China
NCT07687667 Effects of GLP-1RAs on Fertility Outcomes in Obese Women With PCOS (ClinicalTrials.gov ↗)
Polycystic Ovary Syndrome (PCOS), Obesity, Infertility, Female
Not applicable Not yet open Peking University Third Hospital China
NCT07768280 Efficacy and Safety of Hebenrun in Patients With Type 2 Diabetes (ClinicalTrials.gov ↗)
Type 2 Diabetes Mellitus
Not applicable Not yet open Jiangxi University of Traditional Chinese Medicine China
NCT07778719 Metformin-Dapagliflozin Effects on IGF-1 in Male T2DM With MASLD (ClinicalTrials.gov ↗)
Type 2 Diabetes, Metabolic Dysfunction-Associated Steatotic Liver Disease
Not applicable Not yet open The 95th Hospital of Putian๏ผŒPutian, Fujian, China China
NCT06959784 Assessing Incretin Therapy for Cardiovascular Risk Reduction and Diabetes Remission( ITCRDR Study) (ClinicalTrials.gov ↗)
Diabetes Mellitus, Cardiovascular Diseases, Cerebrovascular Disease
Phase 4 By invitation China-Japan Friendship Hospital China
NCT06666933 Study of Time-restricted Eating (TRE) to Clinical Pregnancy Rate in PCOS Women With Glucose Metabolism Disorder Via IVF/ICSI (ClinicalTrials.gov ↗)
PCOS, Glucose Metabolism Disorder, IVF Outcome
Not applicable By invitation RenJi Hospital China
NCT06257966 A Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Dulaglutide in Combination Therapy Diabetes Mellitus Type 2 Patients With Metformin (ClinicalTrials.gov ↗)
Type2 Diabetes Mellitus
Phase 3 Active, closed Beijing Dongfang Biotech Co., Ltd. China
NCT07475546 Combination Gerotherapeutic Interventions for Healthspan Improvement (ClinicalTrials.gov ↗)
Healthspan Improvement, Aging, Longevity
Phase 3 Active, closed AgelessRx USA
NCT02365597 An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer (ClinicalTrials.gov ↗)
Urothelial Cancer
Phase 2 Active, closed Janssen Research & Development, LLC UK, USA, India
NCT04925063 The Effect of Metformin in Patients With Newly Diagnosed mHSPC (ClinicalTrials.gov ↗)
Metastatic Prostate Cancer
Phase 2 Active, closed Sun Yat-sen University China
NCT03006172 To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer
Breast Cancer, Solid Tumor
Phase 1 Active, closed Genentech, Inc. UK, USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied

40 conditions
Condition (as registered)Trials
Breast Cancer2
Longevity2
Aging2
Obesity2
Infertility, Female2
T2DM2
Type 2 Diabetes2
Type 2 Diabetes Mellitus2
Polycystic Ovary Syndrome2
Solid Tumors, Adult1
Solid Tumor1
Urothelial Cancer1
Metastatic Breast Cancer1
GLP-11
Geroscience1
Healthspan Improvement1
Healthy Participants1
Healthy1
Liver Cirrhosis1
T2DM (Type 2 Diabetes Mellitus)1
Adults With Simple Obesity1
Polycystic Ovary Syndrome (PCOS)1
Type2 Diabetes Mellitus1
Schizophrenia1
DNMT3A Gene Mutation1
Diabetes Mellitus1
Cardiovascular Diseases1
Cerebrovascular Disease1
Osteoporosis1
Osteoporosis Fracture1
Metastatic Prostate Cancer1
Chronic Pancreatitis1
Metabolic Dysfunction-Associated Steatotic Liver Disease1
Metabolic Dysfunction-associated Steatotic Liver Disease1
PCOS1
Glucose Metabolism Disorder1
IVF Outcome1
Latent Autoimmune Diabetes in Adults (LADA)1
Insulin Resistance1
Hyperandrogenism1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Eli Lilly and Company2
AgelessRx2
Second Affiliated Hospital, Zhejiang University, School of Medicine2
Peking University Third Hospital2
Genentech, Inc.1
Janssen Research & Development, LLC1
Hoffmann-La Roche1
Bayer1
Institute of Liver and Biliary Sciences, India1
Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.1
Huazhong University of Science and Technology1
Beijing Dongfang Biotech Co., Ltd.1
Central South University1
Institute of Hematology & Blood Diseases Hospital, China1
China-Japan Friendship Hospital1
The First Affiliated Hospital of Xiamen University1
Sun Yat-sen University1
Changhai Hospital1
Jiangxi University of Traditional Chinese Medicine1
The 95th Hospital of Putian๏ผŒPutian, Fujian, China1
Xiqiao Zhou1
RenJi Hospital1
Second Xiangya Hospital of Central South University1
Karolinska Institutet1
04

Trials by country register

A trial with sites in more than one country appears in each of those registers.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Metformin works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Metformin (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 24 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.