Acetaminophen clinical trials
Acetaminophen is named as an intervention in 37 current clinical trials in our USA, Canada, Italy, Israel, Spain, Brazil, South Korea, Turkey, France, Poland, Japan, China, Australia, Ireland, UK, Denmark, Czechia, Mexico, Taiwan, Germany, Sweden, Norway, Belgium, Portugal, Switzerland, Singapore, Egypt, Austria, India and Netherlands registers. 17 are recruiting patients now. The most common phase is Phase 4. The sponsor with the most trials is Merck Sharp & Dohme LLC (7). The most-studied condition is Overweight.
Where Acetaminophen is approved
All regulators →Of the three regulators tracked here, the first to approve Acetaminophen was the US, on 7 Nov 1968. It is approved in 2 of the 3 regulators tracked here.
From the regulators' own registers: FDA Drugs@FDA, the EMA medicines list and Health Canada's Notice of Compliance database. Dates are the first listed approval of a product containing only this substance; combination products and nationally authorised EU medicines are not counted.
Acetaminophen patents and exclusivity
Expiry tracker →Protections still running for marketed products containing Acetaminophen, as listed by the regulators. Expired patents and exclusivities, and discontinued products, are not shown.
- 1 listed patent; the last listed expires 19 Apr 2030 (US 8741959).
Reproduced from the FDA Orange Book and Purple Book (checked 8 Nov 2026) and the European Commission's Union Register of medicinal products (CC BY 4.0; the EU expiry date is calculated exactly as the Commission's register displays it). Listed patents and dates are as submitted to or published by the regulator and may not reflect litigation, invalidation, settlements, lapsed fees or later extensions. This is not legal advice or a freedom-to-operate opinion, and it does not say when a generic or biosimilar will launch.
What health systems spend on Acetaminophen
All medicines →From NHSBSA Prescription Cost Analysis (Open Government Licence v3.0) and CMS State Drug Utilization Data. Both are gross amounts: neither system publishes its discounts or rebates per drug. Products combining several substances are not counted here.
How Acetaminophen works
All drug targets →- Cyclooxygenase inhibitor InhibitorTarget: Cyclooxygenase✓ In ChEMBL and the Guide to Pharmacology
- Anandamide amidohydrolase inhibitor InhibitorTarget: FAAH fatty acid amide hydrolaseChEMBL only
- Vanilloid receptor opener OpenerTarget: TRPV1 transient receptor potential cation channel subfamily V member 1ChEMBL only
- Abdominal painPhase 3
- COVID-19Phase 3
- Cholecystitis, AcutePhase 3
- Chronic painPhase 3
- Inguinal herniaPhase 3
- Low back painPhase 3
- NauseaPhase 3
- Patent ductus arteriosusPhase 3
- SepsisPhase 3
- SneezePhase 3
Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL112, CC BY-SA 3.0. Targets checked against the IUPHAR/BPS Guide to PHARMACOLOGY (2026.3.1), ligand 5239, CC BY-SA 4.0. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.
Patient leaflets for Acetaminophen
The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.
- UKUnited Kingdom: Search MHRA ProductsPatient information leaflets and SmPCs for UK-licensed products.
- USUnited States: Search DailyMedFDA-approved labels, including patient and medication guides.
Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.
Reference identifiers for Acetaminophen
- ATC code
- N02BE01
- ChEMBL
- CHEMBL112
- DrugBank
- DB00316
- PubChem CID
- 1983
- CAS number
- 103-90-2
- FDA UNII
- 362O9ITL9D
- Wikidata
- Q57055
- Wikipedia
- Paracetamol
Codes that identify this medicine in other databases, from Wikidata (CC0), matched by its ChEMBL ID. The ATC code is the WHO classification of what the medicine is used for.
Trials by status
Trials by phase
Clinical trials of Acetaminophen
37 trialsRegisters list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.
Conditions studied with Acetaminophen
58 conditionsAll 58 conditions
| Condition (as registered) | Trials |
|---|---|
| Overweight | 6 |
| Obesity | 6 |
| Paracetamol | 2 |
| Ovarian Cancer | 1 |
| Fallopian Tube Cancer | 1 |
| Primary Peritoneal Cancer | 1 |
| Patent Ductus Arteriosus After Premature Birth | 1 |
| Plasma Cell Myeloma | 1 |
| Lupus Nephritis | 1 |
| Advanced Solid Tumors | 1 |
| Malignant Neoplasm | 1 |
| Non-small Cell Lung Cancer (NSCLC) | 1 |
| Diabetes Mellitus, Type 1 | 1 |
| Esophageal Squamous Cell Carcinoma | 1 |
| Primary Membranous Nephropathy | 1 |
| Healthy Participants | 1 |
| Post Operative Pain, Acute | 1 |
| Plasma Cell Myeloma Refractory | 1 |
| Overweight and/or Obesity | 1 |
| Drug Interaction | 1 |
| Analgesia | 1 |
| Lung Neoplasm Malignant | 1 |
| Relapsed/Refractory Multiple Myeloma | 1 |
| B-cell Acute Lymphoblastic Leukemia | 1 |
| Cefazolin | 1 |
| Obesity, Morbid | 1 |
| Posterior Spinal Instrumentation Patients | 1 |
| Lung Cancer (NSCLC) | 1 |
| Lung Adenocarcinoma | 1 |
| Video Assisted Thoracic Surgery (VATS) | 1 |
| Post Operative Delirium | 1 |
| Post Operative Pain | 1 |
| Post-Op Complication | 1 |
| Post-cardiac Surgery | 1 |
| Post Operative Analgesia | 1 |
| Opioid Consumption, Postoperative | 1 |
| Acetaminophen | 1 |
| Abdominal Surgeries | 1 |
| Surgery | 1 |
| Pain, Postoperative | 1 |
| Extracorporeal Shockwave Lithotripsy | 1 |
| Osteoarthritis, Knee | 1 |
| Cesarean Section | 1 |
| Postoperative Pain | 1 |
| Stomach Neoplasms | 1 |
| Cholecystectomy, Laparoscopic | 1 |
| Cholecystectomy, Robotic | 1 |
| Intrapartum Fever | 1 |
| Chorioamnionitis | 1 |
| Chronic Lymphocytic Leukaemia | 1 |
| Small Lymphocytic Lymphoma | 1 |
| Hematologic Malignancies | 1 |
| Hypotension Drug-Induced | 1 |
| Emergency Surgery | 1 |
| Migraine | 1 |
| Migraine Disease | 1 |
| Migraine Headache | 1 |
| Migraine Headache, With or Without Aura | 1 |
Sponsors
lead sponsor per trial+ 11 more sponsors in the trial list above.
By country register
A trial with sites in more than one country appears in each of those registers.
Related compounds
Questions about Acetaminophen trials
How many clinical trials are testing Acetaminophen?
37 current trials in our USA, Canada, Italy, Israel, Spain, Brazil, South Korea, Turkey, France, Poland, Japan, China, Australia, Ireland, UK, Denmark, Czechia, Mexico, Taiwan, Germany, Sweden, Norway, Belgium, Portugal, Switzerland, Singapore, Egypt, Austria, India and Netherlands registers name Acetaminophen (also registered as Acetaminophen #1) as a drug or biological intervention, as of the registry sync on 10 November 2026. Completed and withdrawn studies are not counted.
Are Acetaminophen trials recruiting patients?
Yes. 17 of the 37 trials are recruiting: 5 with sites in USA, 6 with sites in Canada, 3 with sites in Italy, 3 with sites in Israel, 2 with sites in Spain, 2 with sites in Brazil, 4 with sites in South Korea, 1 with sites in Turkey, 2 with sites in France, 1 with sites in Poland, 3 with sites in Japan, 1 with sites in China, 2 with sites in Australia, 2 with sites in Ireland, 1 with sites in UK, 2 with sites in Denmark, 1 with sites in Czechia, 1 with sites in Mexico, 2 with sites in Taiwan, 1 with sites in Germany, 1 with sites in Sweden, 2 with sites in Norway, 2 with sites in Belgium, 1 with sites in Portugal, 2 with sites in Switzerland, 2 with sites in Singapore, 2 with sites in Egypt, 1 with sites in Austria and 1 with sites in Netherlands. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.
Who sponsors Acetaminophen clinical trials?
Merck Sharp & Dohme LLC (7), Sanofi (3), Hoffmann-La Roche (2) and Eli Lilly and Company (2), among 26 lead sponsors in total. The number in brackets is how many trials each organisation leads.
Are there Acetaminophen clinical trials in Ireland?
Yes. 3 trials in our Ireland register (ClinicalTrials.gov). Some may be the same study registered in both. See the Irish clinical trials register for sites and contacts.
Where does this information come from?
Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Acetaminophen works or whether it is effective, and it is not medical advice.
How this page is built
Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Acetaminophen works or whether it is effective. Each trial links to its own record so you can check it yourself.
- ClinicalTrials.gov (U.S. National Library of Medicine) ↗ Trial IDs, titles, intervention names and synonyms, phase, overall status, lead sponsor and conditions for every trial on this page
This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Acetaminophen (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 10 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.