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Compound · clinical trials

Acetaminophen clinical trials

Also listed in trial records as APAP
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 16 trials in our USA, China, Ireland, UK and India registers that name Acetaminophen as an intervention. Synced 25 Sep 2026
16Current trials
9Recruiting now
10Lead sponsors
5Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

Acetaminophen is named as an intervention in 16 current clinical trials in our USA, China, Ireland, UK and India registers. 9 are recruiting patients now. The most common phase is Phase 3. The sponsor with the most trials is Merck Sharp & Dohme LLC (4). The most-studied condition is Obesity.

Acetaminophen also has an approved-drug profile on this site (FDA label data): Tylenol (Acetaminophen) →

Trials by status

  • Recruiting956%
  • Not yet open213%
  • Active, closed531%

Trials by phase

  • Phase 3638%
  • Phase 1638%
  • Phase 2319%
  • Phase 1/216%
01

Clinical trials of Acetaminophen

16 trials
StudyPhaseStatusLead sponsorRegisters
A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)
NCT06824467 · ClinicalTrials.gov ↗ · Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
Phase 3 Recruiting Merck Sharp & Dohme LLC Ireland, UK, USA
Co-administration of Acetaminophen With Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature Infants
NCT05340582 · ClinicalTrials.gov ↗ · Patent Ductus Arteriosus After Premature Birth
Phase 2 Recruiting Mount Sinai Hospital, Canada Ireland
A Study to Investigate Subcutaneous Isatuximab in Combination With Weekly Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma
NCT06356571 · ClinicalTrials.gov ↗ · Plasma Cell Myeloma Refractory
Phase 2 Recruiting Sanofi USA
Pembrolizumab (MK-3475) Plus Investigational Agents in Resectable Non-small Cell Lung Cancer (NSCLC) (MK-3475-01E/KEYMAKER-U01)
NCT06788912 · Lung Neoplasm Malignant
Phase 2 Recruiting Merck Sharp & Dohme LLC USA
A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)
NCT05319730 · ClinicalTrials.gov ↗ · Esophageal Squamous Cell Carcinoma
Phase 1/2 Recruiting Merck Sharp & Dohme LLC USA, China
A Study to Investigate the Effect of AZD6234, AZD9550, and a Combination of AZD9550 and AZD6234 on Pharmacokinetics of Combined Oral Contraceptive Ethinyl Estradiol/Levonorgestrel in Healthy Female Participants Living With Overweight or Obesity
NCT07013643 · ClinicalTrials.gov ↗ · Healthy Participants
Phase 1 Recruiting AstraZeneca USA
A Research Study Looking Into How NNC0662-0419 Works With Birth Control Pills and Emptying of the Stomach in Women Not Able to Become Pregnant With Excess Body Weight
NCT07525791 · ClinicalTrials.gov ↗ · Overweight, Obesity
Phase 1 Recruiting Novo Nordisk A/S USA
A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight
NCT07738614 · ClinicalTrials.gov ↗ · Obesity, Overweight
Phase 1 Recruiting Eli Lilly and Company USA
A Study of Tirzepatide (LY3298176) in Participants With Type 1 Diabetes Mellitus and Overweight or Obesity
NCT07803744 · ClinicalTrials.gov ↗ · Diabetes Mellitus, Type 1, Overweight, Obesity
Phase 1 Recruiting Eli Lilly and Company USA
A Study of Combogesicยฎ 325 in Adolescent Patients With Moderate to Severe Postoperative Pain Associated With Orthopedic Surgery
NCT07225140 · Post Operative Pain, Acute
Phase 3 Not yet open AFT Pharmaceuticals, Ltd. USA
Influence of HDM1005 on Gastric Emptying and Pharmacokinetics of Metformin, Atorvastatin, Warfarin, and Digoxin
NCT07502001 · ClinicalTrials.gov ↗ · Overweight, Obesity
Phase 1 Not yet open Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. China
A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With ISN/RPS 2003 Class III or IV Lupus Nephritis
NCT04221477 · Lupus Nephritis
Phase 3 Active, closed Hoffmann-La Roche UK, USA
Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma
NCT04270409 · ClinicalTrials.gov ↗ · Plasma Cell Myeloma
Phase 3 Active, closed Sanofi Ireland, UK, USA, China
A Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous Nephropathy
NCT04629248 · ClinicalTrials.gov ↗ · Primary Membranous Nephropathy
Phase 3 Active, closed Hoffmann-La Roche USA, China
Sacituzumab Tirumotecan (MK-2870) Versus Pemetrexed and Carboplatin Combination Therapy in Participants With Epidermal Growth Factor (EGFR)-Mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) Who Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors (MK-2870-009)
NCT06305754 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer (NSCLC)
Phase 3 Active, closed Merck Sharp & Dohme LLC USA, India, China
A Study to Learn About the Effect of Study Medicine Called PF-08653944 on How Quickly the Stomach Empties Its Content in Healthy Adults With Overweight or Obesity
NCT07508241 · ClinicalTrials.gov ↗ · Obesity, Overweight and/or Obesity, Overweight
Phase 1 Active, closed Pfizer USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Acetaminophen across our data

Ireland · EU · US

The same active substance in our other registers, matched by its exact name. Each entry links to the register record it comes from.

Supply shortages

  • Acetaminophen; Oxycodone Hydrochloride TabletUS (FDA) · Resolved · updated 3 Nov 2025
03

Conditions studied with Acetaminophen

18 conditions
Obesity5Overweight5Ovarian Cancer1Fallopian Tube Cancer1Primary Peritoneal Cancer1Plasma Cell Myeloma1Patent Ductus Arteriosus After Premature Birth1Lupus Nephritis1Post Operative Pain, Acute1Lung Neoplasm Malignant1Primary Membranous Nephropathy1Non-small Cell Lung Cancer (NSCLC)1
All 18 conditions
Condition (as registered)Trials
Obesity5
Overweight5
Ovarian Cancer1
Fallopian Tube Cancer1
Primary Peritoneal Cancer1
Plasma Cell Myeloma1
Patent Ductus Arteriosus After Premature Birth1
Lupus Nephritis1
Post Operative Pain, Acute1
Lung Neoplasm Malignant1
Primary Membranous Nephropathy1
Non-small Cell Lung Cancer (NSCLC)1
Esophageal Squamous Cell Carcinoma1
Overweight and/or Obesity1
Drug Interaction1
Diabetes Mellitus, Type 11
Plasma Cell Myeloma Refractory1
Healthy Participants1
04

Sponsors

lead sponsor per trial
Lead sponsorTrials
Merck Sharp & Dohme LLC4
Sanofi2
Hoffmann-La Roche2
Eli Lilly and Company2
Mount Sinai Hospital, Canada1
AFT Pharmaceuticals, Ltd.1
Pfizer1
AstraZeneca1
Novo Nordisk A/S1
Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.1
05

By country register

RegisterTrialsRecruiting
Clinical trials in USA148
Clinical trials in China51
Clinical trials in Ireland32
Clinical trials in UK31
Clinical trials in India10

A trial with sites in more than one country appears in each of those registers.

06

Related compounds

07

Questions about Acetaminophen trials

How many clinical trials are testing Acetaminophen?

16 current trials in our USA, China, Ireland, UK and India registers name Acetaminophen as a drug or biological intervention, as of the registry sync on 25 September 2026. Completed and withdrawn studies are not counted.

Are Acetaminophen trials recruiting patients?

Yes. 9 of the 16 trials are recruiting: 8 with sites in USA, 1 with sites in China, 2 with sites in Ireland and 1 with sites in UK. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Acetaminophen clinical trials?

Merck Sharp & Dohme LLC (4), Sanofi (2), Hoffmann-La Roche (2) and Eli Lilly and Company (2), among 10 lead sponsors in total. The number in brackets is how many trials each organisation leads.

Is there a Acetaminophen shortage?

The registers we track list 1 entry for Acetaminophen: US FDA: resolved. Shortages are product- and country-specific; check with a pharmacist.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Acetaminophen works or whether it is effective, and it is not medical advice.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Acetaminophen works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Acetaminophen (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 25 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.