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AstraZeneca clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine and the EU Clinical Trials Information System (CTIS) — current trials in our USA, China, UK, India, Ireland and EU (CTIS) registers with AstraZeneca as lead sponsor. Synced 26 Sep 2026
408Current trials
183Recruiting now
171Drugs in these trials
6Trial registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 — Top 14 finalist
Compiled from ClinicalTrials.gov and CTIS registry records · Last verified · Editorial standards
At a glance

AstraZeneca is the lead sponsor of 408 current clinical trials in our USA, China, UK, India, Ireland and EU (CTIS) registers. 183 are recruiting patients now. The most common phase is Phase 3. The drugs named most often in its trials are Durvalumab, Carboplatin and Cisplatin. The most-studied condition is Breast Cancer.

Company profile on this site (news, sites, medicines, approvals): AstraZeneca (GB) →

ClinicalTrials.gov trials by status

  • Recruiting18348%
  • Not yet open82%
  • Active, closed18649%
  • By invitation10%

Trials by phase

  • Phase 316443%
  • Phase 25815%
  • Phase 15013%
  • Observational4412%
  • Phase 1/24311%
  • Phase 4113%
  • Not applicable72%
  • Phase 2/310%
01

Clinical trials sponsored by AstraZeneca

378 on ClinicalTrials.gov
StudyPhaseStatusStartRegisters
A Pan-European Post-Authorisation Safety Study: Risk of Pancreatic Cancer Among Type 2 Diabetes Patients Who Initiated Exenatide as Compared With Those Who Initiated Other Non-Glucagon-Like Peptide 1 Receptor Agonists Based Glucose Lowering Drugs
NCT05663515 · Pancreatic Cancer
Observational Recruiting 2024-09 UK
A Trial to Learn How Safe AZD9750 is and How Well it Works in People With Metastatic Prostate Cancer When Given With or Without Other Anticancer Drugs
NCT07336446 · Prostate Cancer
Drug: Saruparib
Phase 1/2 Recruiting 2026-01 UK, USA, China
OverTTuRe: Characteristics, Treatment Patterns and Outcomes of Patients With ATTR Amyloidosis
NCT06355934 · ATTR Amyloidosis
Observational Recruiting 2023-08 UK, USA, China
iCaReMe Global Registry: Multinational Real-world Evidence in Cardiorenal and Metabolic Diseases
NCT03549754 · Type 2 Diabetes, Hypertension, Chronic Kidney Disease
Observational Recruiting 2018-02 India
A Study of Rilvegostomig or Durvalumab Plus Chemotherapy for First-Line Treatment of Biliary Tract Cancer (ARTEMIDE-Biliary02)
NCT07221253 · Biliary Tract Cancer
Phase 3 Recruiting 2025-12 UK, USA, India, China
Roll-over Study for Participants Who Have Completed a Previous Clinical Study With Benralizumab (Fasenra) and Benefit From Continued Treatment
NCT07444567 · Asthma, Eosinophilic Granulomatosis With Polyangiitis (EGPA), Hypereosinophilic Syndrome (HES)
Phase 3 Recruiting 2026-07 UK, USA, India
A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies
NCT06564038 · Chronic Lymphocytic Leukaemia, Small Lymphocytic Lymphoma, Mantle-cell Lymphoma
Phase 1/2 Recruiting 2025-01 UK, USA, China
An Open-label Study to Investigate the Efficacy and Safety of Dato-DXd + Rilvegostomig vs SoC in Adult Participants With High-risk MIUC
NCT07720284 · High-risk Muscle Invasive Urothelial Carcinoma
Phase 3 Recruiting 2026-07 UK, USA, India, China
Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
NCT05624450 · Viral Lung Infection and Acute Respiratory Failure
Phase 3 Recruiting 2022-12 UK, USA, India, China
A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease
NCT06283966 · COPD (Chronic Obstructive Pulmonary Disease)
Phase 3 Recruiting 2024-02 UK, USA, India, China
Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)
NCT07044336 · Endometrial Cancer, Malignant Solid Tumour
Phase 3 Recruiting 2025-08 UK, USA, China
Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations
NCT06357533 · Non-Small Cell Lung Cancer
Phase 3 Recruiting 2024-04 UK, USA, India, China
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.
NCT07511205 · Healthy Participants, Obesity
Phase 1 Recruiting 2026-03 UK, USA
AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)
NCT07611110 · Metastatic Castration-resistant Prostate Cancer
Phase 3 Recruiting 2026-05 UK, USA, India, China
A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Non-Squamous NSCLC
NCT06627647 · Non-squamous Non-small Cell Lung Cancer
Phase 3 Recruiting 2024-11 UK, USA, India, China
Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2
NCT07431281 · Gastric Cancer, Gastroesophageal Junction Adenocarcinoma, Esophageal Cancer
Phase 3 Recruiting 2026-02 UK, USA, India, China
Drug-drug Interaction Study With AZD5335 and Itraconazole in Participants With Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
NCT07402915 · Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal
Phase 1 Recruiting 2026-01 Ireland
A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
NCT06417814 · ClinicalTrials.gov ↗ · Metastatic Non-small Cell Lung Cancer
Phase 3 Recruiting 2024-10 UK, USA, India, China
A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients
NCT06549595 · ClinicalTrials.gov ↗ · Untreated Follicular Lymphoma
Phase 3 Recruiting 2024-08 UK, USA, India, China
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin
NCT07662135 · ClinicalTrials.gov ↗ · Type 2 Diabetes Mellitus, Type 2 Diabetes With Chronic Kidney Disease
Phase 3 Recruiting 2026-07 UK, USA, India, China
Phase 2 Study of Disease Risk Mutation-Guided Finite Acalabrutinib+Venetoclax for Relapsed CLL Post-1L Finite cBTKi+BCL2i ± Obinutuzumab
NCT07024706 · ClinicalTrials.gov ↗ · Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL)
Phase 2 Recruiting 2026-06 Ireland, USA
A Phase I Study of [225Ac]-AZD2284 in Patients With Metastatic Castration-Resistant Prostate Cancer
NCT06879041 · Metastatic Castration-Resistant Prostate Cancer
Drug: AZD2287
Phase 1 Recruiting 2025-03 USA
The Prevalence of COPD in Patients With Cardiovascular Disease and the Benefit of Cardiopulmonary Co-management
NCT06909773 · ClinicalTrials.gov ↗ · Cardiovascular Diseases
Not applicable Recruiting 2025-11 China
A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.
NCT07215702 · Sepsis, Acute Kidney Injury
Drug: AZD4144
Phase 2 Recruiting 2026-02 UK, USA
Phase III, Open-label Study of First-line Osimertinib With or Without Datopotamab Deruxtecan for EGFRm Locally Advanced or Metastatic Non-small Cell Lung Cancer
NCT06350097 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer
Phase 3 Recruiting 2024-04 USA, India, China
AZD5335 vs. Mirvetuximab Soravtansine in FRα-high and AZD5335 vs. Chemotherapy in FRα-low Platinum-resistant Ovarian Cancer
NCT07218809 · ClinicalTrials.gov ↗ · Epithelial Ovarian Cancer
Phase 3 Recruiting 2025-12 Ireland, UK, USA, India, China
A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer
NCT06868277 · ClinicalTrials.gov ↗ · Carcinoma, Non-Small Cell Lung
Phase 3 Recruiting 2025-04 Ireland, UK, USA, China
Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids
NCT06932263 · ClinicalTrials.gov ↗ · Asthma
Phase 2 Recruiting 2025-03 USA, India, China
A Phase III Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With CKD Stage 3b and 4 (BalanceD-CKD)
NCT07624305 · ClinicalTrials.gov ↗ · Renal Insufficiency, Chronic
Phase 3 Recruiting 2026-09 UK, USA, India
A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)
NCT06103864 · ClinicalTrials.gov ↗ · Breast Cancer
Phase 3 Recruiting 2023-11 UK, USA, India, China
AZD5305 hADME in Patients With Advanced Solid Malignancies
NCT06713369 · Locally Advanced or Metastatic Solid Tumor
Drug: Saruparib
Phase 1 Recruiting 2025-04 UK
A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.
NCT06542250 · B-cell Malignancies
Drug: AZD5492
Phase 1/2 Recruiting 2024-09 USA, China
Randomised Clinical Trial to Investigate Efficacy and Safety of Benralizumab 30 mg SC as an add-on Therapy in Uncontrolled Eosinophilic Asthma Patients Treated With Medium-dose ICS-LABA Compared to Conventional Escalation to High-dose ICS-LABA Treatment
NCT06750289 · ClinicalTrials.gov ↗ · Eosinophilic Asthma
Phase 3 Recruiting 2025-03 Ireland, UK, USA, China
Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies
NCT05417594 · Advanced Solid Malignancies
Phase 1/2 Recruiting 2022-06 UK, USA
Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer
NCT07181161 · Metastatic Prostate Cancer
Phase 1/2 Recruiting 2025-10 UK, USA, China
A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
NCT07761117 · ClinicalTrials.gov ↗ · Heart Failure With Preserved Ejection Fraction (HFpEF), Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)
Phase 3 Recruiting 2026-08 UK, USA, India, China
A Study to Evaluate the Efficacy, Safety, and PK of AZD0292 Administered IV in Participants 12 Years of Age and Older With Bronchiectasis and Chronic Pseudomonas Aeruginosa Colonization
NCT07088926 · Bronchiectasis With Pseudomonas Aeruginosa Colonization
Drug: AZD0292
Phase 2 Recruiting 2025-11 UK, USA
Phase I/IIa Study of AZD5335 as Monotherapy and Combination Therapy in Participants With Solid Tumors
NCT05797168 · Ovarian Cancer, Lung Adenocarcinoma, Endometrial Cancer
Phase 1/2 Recruiting 2023-06 UK, USA, China
A Study of AZD0120 in Autoimmune Diseases
NCT07295847 · Systemic Sclerosis, Idiopathic Inflammatory Myopathies, Rheumatoid Arthritis
Drug: AZD0120
Phase 1 Recruiting 2026-01 UK, USA
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus on Background Insulin
NCT07664553 · ClinicalTrials.gov ↗ · Type 2 Diabetes Mellitus
Phase 3 Recruiting 2026-07 USA, India, China
A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure
NCT06742723 · ClinicalTrials.gov ↗ · Chronic Kidney Disease and Hypertension
Phase 3 Recruiting 2025-03 UK, USA, India, China
A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM
NCT07667803 · ClinicalTrials.gov ↗ · Weight Management
Phase 3 Recruiting 2026-06 UK, USA, India, China
A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event
NCT07000357 · ClinicalTrials.gov ↗ · Cardiovascular Disease
Drug: AZD0780
Phase 3 Recruiting 2025-06 UK, USA, India, China
A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer
NCT06764875 · ClinicalTrials.gov ↗ · HER2-positive Gastric Cancer, Gastroesophageal Junction Adenocarcinoma
Phase 3 Recruiting 2025-03 UK, USA, India, China
Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer
NCT05061550 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer
Phase 2 Recruiting 2022-04 Ireland, USA
Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma
NCT06921785 · ClinicalTrials.gov ↗ · Hepatocellular Carcinoma
Phase 3 Recruiting 2025-05 UK, USA, India, China
A Study to Evaluate AZD7760 Safety and Pharmacokinetics in Healthy Adults (Phase I) and Adults With End-stage Kidney Disease on Hemodialysis With a Central Venous Catheter (Phase IIa)
NCT06749457 · Staphylococcus Aureus
Phase 1/2 Recruiting 2024-12 USA
A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease
NCT07082738 · ClinicalTrials.gov ↗ · Chronic Obstructive Pulmonary Disease (COPD)
Phase 2 Recruiting 2025-06 UK, USA, India, China
Investigating the Effect of Itraconazole on the Pharmacokinetics of AZD4144 in Healthy Participants
NCT07685600 · Healthy
Phase 1 Recruiting 2026-07 UK
A Study to Investigate Outcomes With Elecoglipron Compared With Placebo in Adult Participants With Chronic Kidney Disease.
NCT07753993 · ClinicalTrials.gov ↗ · Chronic Kidney Disease
Phase 3 Recruiting 2026-08 UK, USA, India, China
AZD0486 as Monotherapy in B-cell Acute Lymphoblastic Leukaemia
NCT06137118 · ClinicalTrials.gov ↗ · B-cell Acute Lymphoblastic Leukemia (B-ALL)
Phase 1/2 Recruiting 2023-12 UK, USA, China
Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer
NCT06467357 · ClinicalTrials.gov ↗ · Biliary Tract Cancer
Phase 3 Recruiting 2024-08 UK, USA, India, China
CHOICE:Decision Factor of EGFR-TKI in Chinese IV NSCLC
NCT07413757 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer
Observational Recruiting 2026-03 China
Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
NCT06677060 · ClinicalTrials.gov ↗ · Heart Failure
Phase 3 Recruiting 2025-03 UK, USA, India, China
Study of AZD4956 as Monotherapy and in Combination With Anti-Cancer Agents in Participants With Advanced/Metastatic Homologous Recombination Deficient Solid Tumours
NCT07446855 · ClinicalTrials.gov ↗ · Solid Tumours
Drug: Saruparib
Phase 1/2 Recruiting 2026-03 UK, USA
A Study to Evaluate Effect of AZD6234 in Adult Participants With Type 2 Diabetes Mellitus and Obesity or Overweight
NCT07784270 · ClinicalTrials.gov ↗ · Obesity or Overweight, Diabetes Mellitus, Type 2
Drug: AZD6234
Phase 3 Recruiting 2026-08 UK, USA, India, China
An Open-label Study to Assess Safety and Efficacy of SZC in Paediatric Patients With Hyperkalaemia
NCT03813407 · ClinicalTrials.gov ↗ · Hyperkalaemia
Drug: Pumitamig
Phase 3 Recruiting 2019-04 UK, USA, India, China
A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis
NCT07276581 · ClinicalTrials.gov ↗ · Rheumatoid Arthritis
Phase 2 Recruiting 2025-12 UK, USA, China
Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations
NCT07291037 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer (NSCLC)
Phase 3 Recruiting 2025-10 UK, USA, India, China
A Study to Evaluate Effect of AZD6234 in Adult Participants With Obesity or Overweight With Weight-related Comorbidity Without Type 2 Diabetes Mellitus
NCT07784725 · ClinicalTrials.gov ↗ · Obesity or Overweight
Drug: AZD6234
Phase 3 Recruiting 2026-08 USA, India, China
An Open-label Study of AZD0120 in Adults With Multiple Sclerosis
NCT07224373 · ClinicalTrials.gov ↗ · Multiple Sclerosis
Phase 1 Recruiting 2025-12 UK, USA
A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy
NCT05774951 · ClinicalTrials.gov ↗ · Breast Cancer, Early Breast Cancer
Phase 3 Recruiting 2023-03 UK, USA, India, China
An Open-label, Single-arm Study of Prophylaxis for Datopotamab Deruxtecan (Dato-DXd) -Related Stomatitis in Eligible Patients With Metastatic or Inoperable Locally Recurrent Breast Cancer or Locally Advanced or Metastatic Epidermal Growth Factor Receptor-Mutated Non-small Cell Lung Cancer.
NCT07357597 · Stomatitis
Drug: Dato-DXd
Phase 4 Recruiting 2026-06 USA
A Modular, Phase I/II, Multicentre Study to Evaluate AZD4045, in Participants With Relapsed or Refractory Multiple Myeloma
NCT07681596 · Relapsed or Refractory Multiple Myeloma
Phase 1/2 Recruiting 2026-07 USA
Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer
NCT06380751 · ClinicalTrials.gov ↗ · Advanced Breast Cancer
Phase 3 Recruiting 2024-08 UK, USA, India, China
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Alone or in Combination With Dapagliflozin Compared With Placebo in Adults With Type 2 Diabetes Mellitus
NCT07662044 · Type 2 Diabetes Mellitus
Phase 3 Recruiting 2026-07 USA, China
AZD0305 as Monotherapy or in Combination With Anticancer Agents in Participants With Multiple Myeloma
NCT06106945 · Multiple Myeloma
Phase 1/2 Recruiting 2023-12 USA, China
A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy
NCT06129864 · ClinicalTrials.gov ↗ · Locally Advanced Head and Neck Squamous Cell Carcinoma
Phase 3 Recruiting 2023-12 UK, USA, India, China
A Study of Dato-DXd in Inoperable or Metastatic Hormone Receptor-positive, HER2 IHC 0 Breast Cancer
NCT07205822 · ClinicalTrials.gov ↗ · Breast Cancer
Drug: Dato-DXd
Phase 3 Recruiting 2025-10 USA, China
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)
NCT06883305 · ClinicalTrials.gov ↗ · Chronic Obstructive Pulmonary Disease (COPD)
Phase 3 Recruiting 2025-03 UK, USA, India, China
A Phase I/II Study of AZD4512 Monotherapy or in Combination With Anticancer Agents in Participants With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma
NCT07123454 · ClinicalTrials.gov ↗ · B-cell Non-Hodgkin Lymphoma
Phase 1/2 Recruiting 2025-09 UK, USA, China
A Study to Assess Efficacy and Safety of Baxdrostat in Participants With Primary Aldosteronism
NCT07007793 · ClinicalTrials.gov ↗ · Primary Hyperaldosteronism
Phase 3 Recruiting 2025-08 UK, USA, India, China
Study of Safety and PK of AZD0543 in Healthy Adults
NCT07824622 · Human Metapneumovirus Infection
Phase 1 Recruiting 2026-08 USA
Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
NCT06307652 · ClinicalTrials.gov ↗ · Heart Failure and Impaired Kidney Function
Phase 3 Recruiting 2024-04 UK, USA, India, China
A Phase III Study to Investigate the Efficacy and Safety of the Combination of Elecoglipron and Dapagliflozin in Adults With Type 2 Diabetes Mellitus
NCT07662109 · ClinicalTrials.gov ↗ · Type 2 Diabetes Mellitus
Phase 3 Recruiting 2026-07 UK, USA, India, China
Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC
NCT04686305 · Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Phase 1 Recruiting 2021-03 USA, China
A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation
NCT06952803 · ClinicalTrials.gov ↗ · Prostate Cancer
Phase 3 Recruiting 2025-08 UK, USA, India, China
A Trial to Investigate Benralizumab in Children With Eosinophilic Diseases
NCT06512883 · ClinicalTrials.gov ↗ · Eosinophilic Granulomatosis With Polyangiitis (EGPA), Hypereosinophilia Syndrome (HES)
Phase 3 Recruiting 2025-04 USA, India
Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure
NCT06651970 · ClinicalTrials.gov ↗ · Chronic Lymphocytic Leukaemia, Moderate to Severe Cardiac Impairment
Phase 4 Recruiting 2025-02 UK, USA
Post-marketing Phase 4 Safety & Tolerability Study of Breztri aerosphereTM in Indian Patients With Chronic Obstructive Pulmonary Disease
NCT06531798 · ClinicalTrials.gov ↗ · Moderate to Severe COPD
Phase 4 Recruiting 2026-01 India
A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)
NCT06692738 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer
Phase 3 Recruiting 2024-11 UK, USA, India, China
Study of Volrustomig in Women With High Risk Locally Advanced Cervical Cancer (eVOLVE-Cervical)
NCT06079671 · ClinicalTrials.gov ↗ · Locally Advanced Cervical Cancer
Phase 3 Recruiting 2023-09 USA, India, China
Study to Evaluate the Safety and Tolerability of Camizestrant in Combination With Atirmociclib in Women With Advanced Breast Cancer
NCT07427394 · ClinicalTrials.gov ↗ · Advanced Breast Cancer
Phase 2 Recruiting 2026-05 UK, USA
A Study to Investigate the Efficacy and Safety of Anifrolumab Administered as Subcutaneous Injection and Added to Standard of Care Compared With Placebo Added to Standard of Care in Adult Participants With Idiopathic Inflammatory Myopathies (Polymyositis and Dermatomyositis)
NCT06455449 · ClinicalTrials.gov ↗ · Polymyositis, Dermatomyositis
Phase 3 Recruiting 2024-06 UK, USA, India, China
A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
NCT07662213 · ClinicalTrials.gov ↗ · Type 2 Diabetes Mellitus
Phase 3 Recruiting 2026-07 UK, USA, China
A Study to Identify and Characterize Patients With Type 2 Diabetes Mellitus for Possible Participation in Ongoing or Future Type 2 Diabetes Mellitus Clinical Studies
NCT07606066 · ClinicalTrials.gov ↗ · Type 2 Diabetes
Observational Recruiting 2026-05 USA, India
AZD0486 1L Therapy for Elderly or Unfit Participants With LBCL
NCT07215585 · ClinicalTrials.gov ↗ · Large B-cell Lymphoma
Phase 3 Recruiting 2025-11 UK, China
A Study of MET Concordance and Gene Profiling in 1L NSCLC (Genomet)
NCT07613424 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer
Not applicable Recruiting 2026-06 China
A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors
NCT06188520 · ClinicalTrials.gov ↗ · ER+ HER2- Advanced Breast Cancer, High-grade Serous Ovarian Cancer (HGSOC)
Phase 1/2 Recruiting 2023-12 UK, USA
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
NCT06916806 · ClinicalTrials.gov ↗ · Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies, Rheumatoid Arthritis
Drug: AZD5492
Phase 1 Recruiting 2025-05 UK, USA, China
A Study of AZD2962, an IRAK4 Inhibitor (IRAK4 [a Body Protein] Blocker), in Participants With Haematologic Neoplasms (Blood Cancers)
NCT07064122 · ClinicalTrials.gov ↗ · Haematologic Neoplasms
Phase 1 Recruiting 2025-11 UK, USA
Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis
NCT06465810 · ClinicalTrials.gov ↗ · Transthyretin Amyloidosis, ATTR-CM, ATTRv-PN
Observational Recruiting 2024-06 UK, USA, China
Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants
NCT07201558 · ClinicalTrials.gov ↗ · Rheumatoid Arthritis, Systemic Lupus Erythematosus
Phase 1 Recruiting 2025-12 UK, USA, China
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
NCT05489211 · ClinicalTrials.gov ↗ · Endometrial Cancer, Gastric Cancer, Metastatic Castration-resistant Prostate Cancer
Phase 2 Recruiting 2022-09 UK, USA, China
Surovatamig as Consolidation Therapy in Participants With Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated Immunoglobulin Heavy Chain Variable (IGHV)
NCT07509151 · ClinicalTrials.gov ↗ · Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated IGHV
Phase 3 Recruiting 2026-05 UK, USA
A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE
NCT06897930 · ClinicalTrials.gov ↗ · Lupus Erythematosus, Systemic
Phase 1/2 Recruiting 2025-04 UK, USA
DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer
NCT06989112 · ClinicalTrials.gov ↗ · Endometrial Cancer
Phase 3 Recruiting 2025-03 UK, USA, China
A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies
NCT05123482 · ClinicalTrials.gov ↗ · Breast Cancer, Biliary Tract Carcinoma, Ovarian Cancer
Phase 1/2 Recruiting 2021-10 UK, USA, China
Observational Study of Acalabrutinib in Patients With Chronic Lymphocytic Leukaemia in the United Kingdom
NCT05557695 · ClinicalTrials.gov ↗ · Chronic Lymphocytic Leukemia, CLL
Observational Recruiting 2022-10 UK
A Study to Investigate Efficacy and Safety of PT027 Compared With PT007 in Symptomatic Chinese Adults With Asthma
NCT06471257 · ClinicalTrials.gov ↗ · Asthma
Phase 3 Recruiting 2024-06 China

Showing the 100 most recently updated of 378 trials (recruiting first). The rest are in the country registers linked in each row.

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Titles and statuses are copied from the registry as published.

02

AstraZeneca in the EU trials register (CTIS)

30 trials · 1 in Ireland

Authorised or ongoing trials in the EU Clinical Trials Information System with AstraZeneca as sponsor. Some are the same study as a ClinicalTrials.gov record above; the two registries share no common ID. Trials with a site in Ireland are listed first.

StudyPhaseStatusCountries
The MAVRiC Study: A Phase II Study of Disease Risk Mutation-guided Finite Duration Acalabrutinib plus Venetoclax for Relapse in CLL/SLL after First-line Finite covalent BTKi plus BCL2i combination, with or without Obinutuzumab
2024-518858-17-00 · CTIS ↗ · Neoplasms
Phase 2 Ongoing Ireland + 5 more
A Phase III, Open-Label, Randomised, Multicentre, Global Study of Adjuvant Datopotamab Deruxtecan in Combination With Rilvegostomig in Participants With High-risk Muscle Invasive Urothelial Carcinoma (TROPION-Urothelial04).
2025-525030-57-00 · Neoplasms
Phase 3 Authorised Italy, Poland, Spain + 1 more
A Phase III Randomised, Double-Blind, Placebo-Controlled Multicentre Trial to Evaluate the Efficacy and Safety of AZD6234 as an Adjunct to Incretin-based Therapies in Participants with Obesity or Overweight with at Least One Weight-Related Comorbidity With or Without Type 2 Diabetes Mellitus
2025-523295-23-00 · Nutritional and Metabolic Diseases
Drug: AZD6234
Phase 3 Authorised Sweden
A Multicenter, Open-Label, Phase II Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Anifrolumab in Pediatric Participants 5 to < 18 Years of Age with Systemic Lupus Erythematosus.
2025-524578-41-00 · Immune System Diseases
Phase 2 Authorised Belgium, Portugal
A trial to learn how safe anifrolumab is, how it moves throughout the body over time, and how it affects the body of adults with systemic lupus erythematosus
2026-526171-32-00 · Immune System Diseases
Phase 1 Authorised Poland, Hungary
A Phase III Open-Label, Randomised, Multicentre Study of Consolidation with a Single Administration of AZD0120, a Dual-Targeting Autologous Chimeric Antigen Receptor T-cell (CAR T) Therapy Directed Against BCMA and CD19, Compared with Continuous Standard Therapy in Participants with NDMM Who Are Ineligible to Receive ASCT as Initial Therapy (DURGA-5).
2025-524014-29-00 · Neoplasms
Phase 3 Authorised Poland, Italy, Denmark + 4 more
A Modular Open-label, Phase I/IIa Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of Ascending Doses of AZD4956 as Monotherapy, and in Combination with Anti-Cancer Agents in Participants with Advanced/Metastatic Homologous Recombination Repair Defective Solid Tumours (PARTHENON)
2025-524171-22-00 · Neoplasms
Drug: Saruparib
Phase 1 Authorised Spain
SERAFA-1: A Single arm, Open label, Multicentre, Phase IIIb Study Of Camizestrant plus Ribociclib in 1st line Treatment of ER-positive, HER2-negative Advanced Breast Cancer Patients
2025-523444-12-00 · Neoplasms
Phase 3 Authorised Poland, Spain, France + 2 more
ROSY-F: Roll-Over Study for Participants Who Have Completed a Previous Study with Benralizumab (Fasenra) and Are Judged by the Investigator to Clinically Benefit from Continued Treatment
2025-523307-29-00 · Respiratory Tract Diseases
Phase 3 Authorised Denmark, Belgium, France + 4 more
A Phase IIb Study to Evaluate the Efficacy, Safety, and Tolerability of AZD8965 in Participants with Idiopathic Pulmonary Fibrosis (IPF)) (ARGiNAUT)
2025-525016-41-00 · Respiratory Tract Diseases
Phase 2 Ongoing Poland, Hungary, Netherlands + 7 more
A Randomized, Double-blind, Parallel-group Phase III Study to Evaluate the Efficacy, Safety, and Tolerability of Elecoglipron Compared with Placebo in Adults with Type 2 Diabetes Mellitus on Background Insulin (Eluminate-3)
2025-523935-20-00 · Nutritional and Metabolic Diseases
Phase 3 Ongoing Poland, Germany, Bulgaria + 1 more
A Phase III, Multicentre, Randomised, Open-label Study to Compare the Efficacy and Safety of AZD0486 plus Rituximab versus Chemotherapy plus Rituximab in Previously Untreated Participants with Follicular Lymphoma (SOUNDTRACK-F1)
2023-510098-33-01 · Neoplasms
Phase 3 Authorised Denmark
A Phase III, Randomized, Double-blind, Parallel-group, Placebo controlled, Multicenter Study to Evaluate the Effect of Elecoglipron in Reducing Cardiovascular Outcomes in Participants with HFpEF and HFmrEF (Elevate-HF)
2026-526304-79-00 · Cardiovascular Diseases
Phase 3 Ongoing Spain, Hungary, Germany + 11 more
A Phase III, Randomized, Double-blind, Parallel-group, Placebo-controlled Multicenter Study to Evaluate the Effect of Elecoglipron in Reducing Renal Outcomes and Mortality in Participants with Chronic Kidney Disease (Elevate-CKD)
2025-523994-41-00 · Cardiovascular Diseases
Phase 3 Ongoing Czechia, Italy, Hungary + 11 more
A Phase IIb, randomised, double-blind, placebo-controlled, multicentre study to evaluate the efficacy and safety of concomitant use of eplontersen and ALXN2220 compared with eplontersen and placebo in adult participants with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM).
2025-523908-75-00 · Cardiovascular Diseases
Phase 2 Authorised Germany, Italy, Spain + 2 more
A Phase 2, Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of Surovatamig in Adults with Antibody-mediated Kidney Disease
2025-524139-38-00 · Immune System Diseases
Phase 2 Authorised France, Germany, Italy + 3 more
A Phase II, Randomized, Double-blind, 3-Period Cross-over, Dose‑ranging Study to Assess the Efficacy and Safety of Glycopyrronium (GP) versus Placebo in Participants of 4 to Less than 12 Years of Age with Asthma Receiving Background Budesonide and Formoterol Fumarate (BFF) (FAROS)
2025-524914-26-00 · CTIS ↗ · Respiratory Tract Diseases
Phase 2 Ongoing Czechia, Poland, Hungary
Phase III, Open-label Trial to Evaluate Pharmacokinetics, Pharmacodynamics, Safety, Efficacy, and Immunogenicity of Benralizumab in Children with Eosinophilic Disease (CLIPS)
2023-508533-14-00 · CTIS ↗ · Immune System Diseases
Phase 3 Ongoing Poland, Netherlands, France
A Master Protocol of a Phase II, Open-label, Multicenter, Global Platform Study to Evaluate the Safety and Efficacy of Immunotherapy With or Without Other Anticancer Drugs in Participants with Unresectable Stage III Non-small Cell Lung Cancer Planning to Undergo Concurrent Chemoradiotherapy (AQUARIUS)
2025-523599-21-00 · CTIS ↗ · Neoplasms
Phase 2 Authorised Spain, Germany
A Phase I/II Open-label, Dose Escalation and Dose Expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of AZD6621, a T Cell-engaging Antibody That Targets STEAP2, CD3, and CD8 in Adult Participants With Metastatic Prostate Cancer (ACTIVATED-4-PC)
2025-520626-37-00 · CTIS ↗ · Neoplasms
Phase 1 Ongoing Belgium, Spain, Poland + 2 more
Multinational, Interventional, 52-week, Open-label, Single-arm Study to Evaluate the Treatment Outcomes of Anifrolumab 120 mg Subcutaneous Once Weekly in Immunosuppressant-naïve and Biologic-naïve Systemic Lupus Erythematosus (SUNFLOWER)
2025-523670-17-00 · CTIS ↗ · Immune System Diseases
Phase 3 Ongoing Poland, Germany, Italy + 2 more
A Master Protocol of an Open-Label, Multi-Drug, Multi-Centre, Phase II Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Antitumour Activity of Novel Combinations in Participants with Locally Advanced or Metastatic Non-Small Cell Lung Cancer (LIBRA)
2025-524843-11-00 · CTIS ↗ · Neoplasms
Phase 2 Ongoing France, Italy, Spain
A Phase III Open-label, Randomised, Multicentre Study Comparing AZD0120, a Dual-Targeting Autologous Chimeric Antigen Receptor T-cell (CAR-T) Therapy Directed Against BCMA and CD19, versus Standard Regimens in Participants with Relapsed Refractory Multiple Myeloma (DURGA-4)
2025-523285-25-00 · CTIS ↗ · Neoplasms
Phase 3 Ongoing Norway, Poland, Spain + 3 more
A Phase Ib/II Open-Label, Multicentre Platform Study Evaluating Novel Combinations in Participants with Advanced or Metastatic Non-Small Cell Lung Cancer (ALTAIR)
2024-519786-22-01 · CTIS ↗ · Neoplasms
Phase 1 Authorised Germany, Spain, France + 4 more
A Modular Phase I/II Open-label Dose Escalation and Dose Expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of AZD9793, a T cell-engaging Antibody Targeting Glypican-3 (GPC3) in Adult Participants with Advanced or Metastatic Solid Tumours (RHEA-1)
2024-516698-56-00 · CTIS ↗ · Neoplasms
Phase 1 Authorised Spain
A Phase IIb, Randomised, Multicentre, Double-Blind Study to Evaluate the Effect of Baxdrostat in Combination with Dapagliflozin Compared with Baxdrostat on Albuminuria in Participants with Chronic Kidney Disease and High Blood Pressure
2025-522407-23-00 · CTIS ↗ · Cardiovascular Diseases
Phase 2 Ongoing Spain, Bulgaria
A study to investigate safety, tolerability, pharmacokinetics, and pharmacodynamics of surovatamig in adult participants with rheumatoid arthritis or systemic lupus erythematosus.
2025-522273-10-00 · CTIS ↗ · Immune System Diseases
Phase 1 Ongoing Germany, Spain, Belgium
A Phase IIa, Randomised, Double-blind, Placebo-controlled, Multicentre Study to Assess the Efficacy, Safety, and Tolerability of AZD4144 in Participants with Sepsis-associated Acute Kidney Injury (SERENIA)
2025-522232-13-00 · CTIS ↗ · Not possible to specify
Drug: AZD4144
Phase 2 Ongoing Germany, France, Spain + 6 more
A Modular Phase I/II, Open-label, Multi-Centre Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants with Advanced Haematologic Malignancies with KMT2Ar, NPM1m, or Other Genotypes Associated with HOX Overexpression
2025-521299-76-00 · CTIS ↗ · Neoplasms
Phase 1 Ongoing Germany, Italy, Denmark
A Phase III, Randomized, Open-Label, Multicenter, Global Study of Puxitatug Samrotecan (AZD8205) Monotherapy versus Physician’s Choice of Chemotherapy in Participants with B7-H4-Selected Advanced/Metastatic Endometrial Cancer Who Progressed On or After Platinum-Based Chemotherapy and Anti-PD-1/Anti-PD-L1 Therapy (Bluestar-Endometrial01)
2024-518777-34-00 · CTIS ↗ · Neoplasms
Phase 3 Ongoing Italy, Netherlands, Lithuania + 12 more
03

Drugs in AstraZeneca trials

171 compounds

Drugs and biologicals named as interventions in these trials, with the number of this sponsor's trials that name each one. Placebos and generic comparators are excluded.

+ 131 more in the trial list above.

04

Conditions in AstraZeneca trials

309 conditions
05

By trial register

RegisterTrialsRecruiting
Clinical trials in USA298148
Clinical trials in China220113
Clinical trials in UK195100
Clinical trials in India10147
Clinical trials in Ireland106
EU register (CTIS)30—

A trial with sites in more than one country appears in each of those registers; recruiting counts cover the trials listed on this page.

06

Other sponsors in Breast Cancer

SponsorTrials
Fudan University48
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University21
Second Affiliated Hospital, Zhejiang University, School of Medicine19
Shengjing Hospital15
Pfizer12
Sichuan Baili Pharmaceutical12
Cancer Institute and Hospital, Chinese Academy of Medical Sciences12
Hoffmann-La Roche10
Ruijin Hospital10
Xijing Hospital9

Sponsors with the most current trials registered for this condition.

07

Questions about AstraZeneca trials

How many clinical trials does AstraZeneca sponsor?

AstraZeneca is the lead sponsor of 378 current trials on ClinicalTrials.gov in our USA, China, UK, India and Ireland registers, and 30 authorised or ongoing trials in the EU register (CTIS), as of the registry sync on 26 September 2026. Completed and withdrawn studies are not counted.

Are AstraZeneca trials recruiting?

Yes. 183 of its 378 ClinicalTrials.gov trials are recruiting. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Which drugs is AstraZeneca testing?

Its current trials name 171 drugs and biologicals as interventions. The most frequent are Durvalumab (65), Carboplatin (45), Cisplatin (36), Rilvegostomig (32) and Paclitaxel (30). The number in brackets is how many of its trials name each drug.

Does AstraZeneca have clinical trials in Ireland?

Yes. 10 trials in our Ireland register (ClinicalTrials.gov), and 1 trial in the EU register (CTIS) with a site in Ireland. Some may be the same study registered in both. See the Irish clinical trials register for sites and contacts.

Where does this information come from?

Every trial, status, phase and condition on this page is copied from public ClinicalTrials.gov and EU CTIS records by a daily sync, grouped by the sponsor name each registry records. It says nothing about the organisation beyond its registered trials, and it is not medical advice.

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How this page is built

Everything on this page is copied from public registry records — it is not written from memory, and nothing here describes the organisation beyond its registered trials. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our trial registers and groups every current trial by its lead sponsor name, ignoring legal-form suffixes such as Inc. or Ltd. A small, hand-checked list joins the same organisation's different registry names (for example its EU legal entity). There is no AI drafting and no per-sponsor editorial pass. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The the registries data on this page was last retrieved on 26 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.