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Priya Life Science Compound trial record
Compound · clinical trials

AZD0120 clinical trials

Also listed in trial records as GC012F, CD19-BCMA CAR-T cells
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 18 trials in our China, USA, UK, Canada, Australia, Germany, Spain, France, Italy, Poland, Brazil, Japan, South Korea, Taiwan, Sweden, Denmark, Norway, Singapore and Egypt registers that name AZD0120 as an intervention. Synced 9 Nov 2026
18Current trials
15Recruiting now
9Lead sponsors
19Country registers
At a glance

AZD0120 is named as an intervention in 18 current clinical trials in our China, USA, UK, Canada, Australia, Germany, Spain, France, Italy, Poland, Brazil, Japan, South Korea, Taiwan, Sweden, Denmark, Norway, Singapore and Egypt registers. 15 are recruiting patients now. The most common phase is Phase 1/2. The sponsor with the most trials is AstraZeneca (7). The most-studied condition is Systemic Sclerosis. The EU clinical trials register (CTIS) separately lists 3 authorised or ongoing trials.

Patient leaflets for AZD0120

The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.

  • UK
    United Kingdom: Search MHRA Products
    Patient information leaflets and SmPCs for UK-licensed products.
  • US
    United States: Search DailyMed
    FDA-approved labels, including patient and medication guides.

Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.

Trials by status

  • Recruiting1583%
  • Not yet open211%
  • Active, closed16%

Trials by phase

  • Phase 1/2739%
  • Early Phase 1528%
  • Phase 3317%
  • Phase 1317%
01

Clinical trials of AZD0120

18 trials
StudyPhaseStatusLead sponsorRegisters
A Study Comparing AZD0120, a Dual-targeted CAR-T Against B-cell Maturation Antigen (BCMA) and CD19, Versus Standard Regimens in Participants With Relapsed Refractory Multiple Myeloma (DURGA-4)
NCT07391657 · Relapsed Refractory Multiple Myeloma
Phase 3 Recruiting AstraZeneca UK, USA, China, Germany, France, Spain, Italy, Poland, Norway, Canada, Brazil, Japan, South Korea, Taiwan, Australia
A Phase III, Multicentre Study to Evaluate Consolidation Treatment With AZD0120 Compared With ASCT, in Participants With Newly Diagnosed Multiple Myeloma Who Are Transplant Eligible (DURGA-6).
NCT07735637 · Newly Diagnosed Multiple Myeloma (NDMM)
Phase 3 Recruiting AstraZeneca UK, USA, China, Germany, France, Spain, Italy, Denmark, Poland, Norway, Canada, Brazil, Japan, South Korea, Taiwan, Singapore, Australia, Egypt
Study of AZD0120 in Newly Diagnosed Multiple Myeloma Ineligible for ASCT
NCT07764978 · Newly Diagnosed Multiple Myeloma
Phase 3 Recruiting AstraZeneca UK, USA, Germany, France, Spain, Italy, Sweden, Denmark, Poland, Canada, Brazil, Japan, South Korea, Taiwan, Australia
AZD0120 in Relapsed/Refractory Multiple Myeloma (DURGA-1)
NCT05850234 · Relapsed/Refractory Multiple Myeloma
Phase 1/2 Recruiting AstraZeneca USA
A Study of GC012F in Patients With Relapsed/Refractory Multiple Myeloma
NCT06235229 · ClinicalTrials.gov ↗ · Multiple Myeloma
Phase 1/2 Recruiting Gracell Biotechnologies (Shanghai) Co., Ltd China
A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE
NCT06897930 · Lupus Erythematosus, Systemic
Phase 1/2 Recruiting AstraZeneca UK, USA, Canada, Australia
CD19-BCMA CART Cell Therapy for Refractory SLE-LN, SSc, and pSS-PAH
NCT06947460 · ClinicalTrials.gov ↗ · Refractory Lupus Nephritis, Systemic Sclerosis, Primary Sjogren's Syndrome Combined With Pulmonary Hypertension
Phase 1/2 Recruiting Beijing GoBroad Hospital China
A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis.
NCT07081646 · Relapsed AL Amyloidosis, Refractory AL Amyloidosis, Light Chain Amyloidosis
Phase 1/2 Recruiting Alexion Pharmaceuticals, Inc UK, USA, Canada
A Study of AZD0120 in Autoimmune Diseases
NCT07295847 · Systemic Sclerosis, Idiopathic Inflammatory Myopathies, Rheumatoid Arthritis
Phase 1/2 Recruiting AstraZeneca UK, USA, Germany, Spain, Sweden, Australia
A Phase I, Open-label, Multicenter Study to Evaluate the Safety, Tolerability, Cellular Kinetics, Immunogenicity, Pharmacodynamics, and Preliminary Efficacy of AZD0120 in Participants With Multiple Myeloma (DURGA-2)
NCT07073547 · Multiple Myeloma
Phase 1 Recruiting AstraZeneca USA
Study of GC012F, CAR-T Therapy Targeting CD19 and BCMA in Chinese Participants With Relapsed or Refractory AL Amyloidosis
NCT07250269 · ClinicalTrials.gov ↗ · Relapsed/Refractory AL Amyloidosis
Phase 1 Recruiting Gracell Biotechnologies (Shanghai) Co., Ltd China
Dual Target CAR-T Cell Treatment for Refractory Systemic Lupus Erythematosus (SLE) Patients
NCT05858684 · ClinicalTrials.gov ↗ · CAR-T Cell Therapy
Early Phase 1 Recruiting RenJi Hospital China
GC012F Injection in the Treatment of Refractory Generalized Myasthenia Gravis(24103)
NCT07058298 · ClinicalTrials.gov ↗ · Generalized Myasthenia Gravis (gMG)
Early Phase 1 Recruiting Daishi Tian China
GC012F Injection in Refractory Idiopathic Inflammatory Myopathy
NCT07086404 · ClinicalTrials.gov ↗ · Idiopathic Inflammatory Myopathy (IIM)
Early Phase 1 Recruiting Daishi Tian China
CAR-T Therapy Targeting CD19 and BCMA in Highly Sensitized Kidney Transplant Participants
NCT07350837 · ClinicalTrials.gov ↗ · Highly Sensitized Patients Awaiting Kidney Transplant
Early Phase 1 Recruiting Tongji Hospital China
An Early Exploratory Clinical Study of GC012F Injection in the Treatment of Refractory Generalized Myasthenia Gravis
NCT06759948 · ClinicalTrials.gov ↗ · Generalized Myasthenia Gravis (gMG)
Phase 1 Not yet open Chongbo Zhao China
CD19/BCMA CAR-T for SLE
NCT07266337 · ClinicalTrials.gov ↗ · SLE - Systemic Lupus Erythematosus
Early Phase 1 Not yet open Chengdu Ucello Biotechnology Co., Ltd China
A Study of GC012F Injection in Subjects With Refractory Systemic Lupus Erythematosus
NCT06530849 · ClinicalTrials.gov ↗ · Refractory Systemic Lupus Erythematosus
Phase 1/2 Active, closed Gracell Biotechnologies (Shanghai) Co., Ltd China

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

AZD0120 in the EU trials register (CTIS)

3 trials

Authorised or ongoing trials in the EU Clinical Trials Information System that list a product containing AZD0120. Many trials are registered in both CTIS and ClinicalTrials.gov, so these are shown separately rather than added to the count above. Trials with a site in Ireland are listed first.

StudyPhaseStatusSponsorCountries
A Phase III, Open-label, Multicentre, Randomised Study Comparing Consolidation Treatment with AZD0120, an Autologous Dual Targeting Chimeric Antigen Receptor T-cell (CAR-T) Therapy Directed Against BCMA and CD19, versus Autologous Stem Cell Transplant (ASCT) in Participants with Newly Diagnosed Multiple Myeloma who are Transplant Eligible (TE NDMM) (DURGA-6)
2026-525367-40-00 · CTIS ↗ · Neoplasms
Phase 3 Authorised AstraZeneca AB Germany, Spain, Norway + 4 more
A Phase III Open-Label, Randomised, Multicentre Study of Consolidation with a Single Administration of AZD0120, a Dual-Targeting Autologous Chimeric Antigen Receptor T-cell (CAR T) Therapy Directed Against BCMA and CD19, Compared with Continuous Standard Therapy in Participants with NDMM Who Are Ineligible to Receive ASCT as Initial Therapy (DURGA-5).
2025-524014-29-00 · Neoplasms
Phase 3 Authorised AstraZeneca AB Poland, Italy, Denmark + 4 more
A Phase III Open-label, Randomised, Multicentre Study Comparing AZD0120, a Dual-Targeting Autologous Chimeric Antigen Receptor T-cell (CAR-T) Therapy Directed Against BCMA and CD19, versus Standard Regimens in Participants with Relapsed Refractory Multiple Myeloma (DURGA-4)
2025-523285-25-00 · CTIS ↗ · Neoplasms
Phase 3 Ongoing AstraZeneca AB Norway, Poland, Spain + 3 more
03

Conditions studied with AZD0120

23 conditions
Systemic Sclerosis2Multiple Myeloma2Generalized Myasthenia Gravis (gMG)2Newly Diagnosed Multiple Myeloma1Lupus Erythematosus, Systemic1Relapsed Refractory Multiple Myeloma1Relapsed AL Amyloidosis1Refractory AL Amyloidosis1Light Chain Amyloidosis1Amyloidosis1Newly Diagnosed Multiple Myeloma (NDMM)1Idiopathic Inflammatory Myopathies1
All 23 conditions
Condition (as registered)Trials
Systemic Sclerosis2
Multiple Myeloma2
Generalized Myasthenia Gravis (gMG)2
Newly Diagnosed Multiple Myeloma1
Lupus Erythematosus, Systemic1
Relapsed Refractory Multiple Myeloma1
Relapsed AL Amyloidosis1
Refractory AL Amyloidosis1
Light Chain Amyloidosis1
Amyloidosis1
Newly Diagnosed Multiple Myeloma (NDMM)1
Idiopathic Inflammatory Myopathies1
Rheumatoid Arthritis1
Relapsed/Refractory Multiple Myeloma1
Highly Sensitized Patients Awaiting Kidney Transplant1
Relapsed/Refractory AL Amyloidosis1
Idiopathic Inflammatory Myopathy (IIM)1
CAR-T Cell Therapy1
Refractory Systemic Lupus Erythematosus1
SLE - Systemic Lupus Erythematosus1
Refractory Lupus Nephritis1
Primary Sjogren's Syndrome Combined With Pulmonary Hypertension1
Other Autoimmune Diseases (AID)1
06

Related compounds

07

Questions about AZD0120 trials

How many clinical trials are testing AZD0120?

18 current trials in our China, USA, UK, Canada, Australia, Germany, Spain, France, Italy, Poland, Brazil, Japan, South Korea, Taiwan, Sweden, Denmark, Norway, Singapore and Egypt registers name AZD0120 (also registered as GC012F) as a drug or biological intervention, as of the registry sync on 9 November 2026. Completed and withdrawn studies are not counted.

Are AZD0120 trials recruiting patients?

Yes. 15 of the 18 trials are recruiting: 9 with sites in China, 8 with sites in USA, 6 with sites in UK, 5 with sites in Canada, 5 with sites in Australia, 4 with sites in Germany, 4 with sites in Spain, 3 with sites in France, 3 with sites in Italy, 3 with sites in Poland, 3 with sites in Brazil, 3 with sites in Japan, 3 with sites in South Korea, 3 with sites in Taiwan, 2 with sites in Sweden, 2 with sites in Denmark, 2 with sites in Norway, 1 with sites in Singapore and 1 with sites in Egypt. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors AZD0120 clinical trials?

AstraZeneca (7), Gracell Biotechnologies (Shanghai) Co., Ltd (3), Daishi Tian (2) and Alexion Pharmaceuticals, Inc (1), among 9 lead sponsors in total. The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how AZD0120 works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how AZD0120 works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists AZD0120 (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 9 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.