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Clinical Trials in the UK / NCT07571746
Recruiting Phase 2

A Study to Assess the Effect of Surovatamig in Adult Participants With Antibody-mediated Kidney Disease

NCT07571746 · tracked via the Priya Life Science UK tracker
Sponsor
AstraZeneca
Phase
Phase 2
Started
2026-03-28
Last updated
2026-09-11

Condition(s) studied

Primary Membranous Nephropathy

Investigational drug(s) / intervention(s)

Surovatamig

Surovatamig: Participants will receive Surovatamig subcutaneously

Study summary

The purpose of this study is to assess the safety, tolerability, pharmacokinetic, and efficacy of surovatamig administered by subcutaneous injection in adult participants with primary membranous nephropathy.

Eligibility

Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria: 1. Participant must be 18 (or the legal age of consent in the jurisdiction in which the study is taking place) to 75 years of age inclusive, at the time of signing the informed consent. 2. Diagnosis of anti-PLA2R antibody-positive pMN. 3. All participants must have received SoC therapy with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers for ≥ 4 weeks, with exceptions in case of intolerance, contraindications, or low blood pressure, before the screening period. 4. Positive for anti-PLA2R. 5. Up to date with required vaccinations as per institutional guidelines (eg, influenza, pneumococcal, and severe acute respiratory syndrome coronavirus 2) prior to study entry. 6. Male and/or female assigned at birth, inclusive of all gender identities. Contraceptive use by participants or participant partners should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies. 7. Capable of giving signed informed consent Exclusion Criteria: 1. Receipt of B cell-depleting therapy including CD19- or CD20-directed monoclonal antibodies \< 9 months before screening. 2. Immunomodulatory therapy \<3 months before screening. 3. Secondary causes of membranous nephropathy 4. Diabetes mellitus with haemoglobin A1C \> 8.5% tested at screening visit. 5. Malignancies 6. History of HLH/MAS. 7 Significant CNS co-morbidity 8\. History of chronic significant respiratory disease. 9. Significant opportunistic infection in the medical history deemed relevant by the Investigator. 10\. Abnormal vital sign after 10 minutes sitting at rest. 11. Administration of corticosteroids such as prednisolone at doses exceeding 20 mg or an equivalent agent \< 2 months before screening.

Primary outcome measure(s)

Trial sites (24)

FacilityCityRegionStatus
Research Site Los Angeles California Withdrawn
Research Site Los Angeles California Not Yet Recruiting
Research Site Iowa City Iowa Not Yet Recruiting
Research Site Bethesda Maryland Not Yet Recruiting
Research Site New York New York Not Yet Recruiting
Research Site Houston Texas Recruiting
Research Site Houston Texas Not Yet Recruiting
Research Site Ieper Belgium Not Yet Recruiting
Research Site Bordeaux France Not Yet Recruiting
Research Site Créteil France Withdrawn
Research Site Lyon France Not Yet Recruiting
Research Site Nantes France Not Yet Recruiting
Research Site Nîmes France Not Yet Recruiting
Research Site Düsseldorf Germany Not Yet Recruiting
Research Site München Germany Not Yet Recruiting
Research Site Brescia Italy Not Yet Recruiting
Research Site Rozzano Italy Not Yet Recruiting
Research Site Torino Italy Not Yet Recruiting
Research Site Verona Italy Withdrawn
Research Site Lodz Poland Not Yet Recruiting
Research Site Barcelona Spain Not Yet Recruiting
Research Site Madrid Spain Not Yet Recruiting
Research Site London United Kingdom Not Yet Recruiting
Research Site Manchester United Kingdom Not Yet Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07571746 on ClinicalTrials.gov ↗ ← All trials in the UK