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Compound · clinical trials

Capivasertib

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 12 trials in our USA, UK, China and India registers that name Capivasertib as an intervention. Synced 24 Sep 2026
12Trials tracked
3Recruiting now
5Lead sponsors
4Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards

Capivasertib is named as a drug or biological intervention in 12 clinical trials in our USA, UK, China and India trial registers, 3 of which are recruiting. Lead sponsors include AstraZeneca (8), Stemline Therapeutics, Inc. (1) and Relay Therapeutics, Inc. (1). Registered phases: Phase 3, Phase 1/2 and Phase 1. Conditions studied include Breast Cancer; Triple Negative Breast Neoplasms; Locally Advanced (Inoperable) or Metastatic Breast Cancer.

01

Clinical trials of Capivasertib

12 trials
NCT IDStudyPhaseStatusLead sponsorRegister
NCT06982521 Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer (ClinicalTrials.gov ↗)
PIK3CA Mutation, HER2- Negative Breast Cancer, Hormone Receptor Positive Tumor
Phase 3 Recruiting Relay Therapeutics, Inc. UK, USA
NCT07287917 Study of AMXT 1501 and DFMO in Combination With Standard Therapies in Advanced Solid Tumors (ClinicalTrials.gov ↗)
Melanoma (Skin Cancer), HER2-low Hormone Receptor Positive Breast Cancer
Phase 1/2 Recruiting Aminex Therapeutics, Inc. USA
NCT07343960 A Phase I Study to Investigate the Pharmacokinetics and Safety of Capivasertib in Participants With Moderate Hepatic Impairment (ClinicalTrials.gov ↗)
Moderate Hepatic Impairment
Phase 1 Recruiting AstraZeneca USA
NCT07486648 Osimertinib Plus Capivasertib in NSCLC With PIK3CA/AKT1/PTEN Alterations Following Prior 1L Osimertinib (ClinicalTrials.gov ↗)
Lung Cancer (NSCLC), Lung Cancer (Non-Small Cell), Advanced Non-small-cell Lung Cancer
Phase 1/2 Not yet open Shanxi Province Cancer Hospital China
NCT03997123 Capivasertib+Paclitaxel as First Line Treatment for Patients With Locally Advanced or Metastatic TNBC
Triple Negative Breast Neoplasms
Phase 3 Active, closed AstraZeneca UK, USA, India, China
NCT04305496 Capivasertib+Fulvestrant vs Placebo+Fulvestrant as Treatment for Locally Advanced (Inoperable) or Metastatic HR+/HER2- Breast Cancer (ClinicalTrials.gov ↗)
Locally Advanced (Inoperable) or Metastatic Breast Cancer
Phase 3 Active, closed AstraZeneca UK, USA, China
NCT04493853 Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency (ClinicalTrials.gov ↗)
Hormone-Sensitive Prostate Cancer
Phase 3 Active, closed AstraZeneca UK, USA, India, China
NCT04862663 Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292) (ClinicalTrials.gov ↗)
Locally Advanced (Inoperable) or Metastatic Breast Cancer
Phase 3 Active, closed AstraZeneca UK, USA, India, China
NCT05348577 Study of Capivasertib + Docetaxel vs Placebo + Docetaxel as Treatment for Metastatic Castration Resistant Prostate Cancer (mCRPC)
Prostate Cancer
Phase 3 Active, closed AstraZeneca UK, USA, India, China
NCT06635447 Capivasertib+Fulvestrant asTreatment for Locally Advanced(Inoperable) or Metastatic HR+/HER2- Breast Cancer in Chinese Patients (ClinicalTrials.gov ↗)
Breast Cancer
Phase 3 Active, closed AstraZeneca China
NCT03742102 A Study of Novel Anti-cancer Agents in Patients With Metastatic Triple Negative Breast Cancer (ClinicalTrials.gov ↗)
Triple Negative Breast Neoplasms
Phase 1/2 Active, closed AstraZeneca UK, USA
NCT05563220 Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Participants With Metastatic Breast Cancer
Breast Cancer, Metastatic Breast Cancer
Phase 1/2 Active, closed Stemline Therapeutics, Inc. UK, USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied

15 conditions
Condition (as registered)Trials
Breast Cancer3
Triple Negative Breast Neoplasms2
Locally Advanced (Inoperable) or Metastatic Breast Cancer2
Prostate Cancer1
Metastatic Breast Cancer1
Hormone-Sensitive Prostate Cancer1
PIK3CA Mutation1
HER2- Negative Breast Cancer1
Hormone Receptor Positive Tumor1
Melanoma (Skin Cancer)1
HER2-low Hormone Receptor Positive Breast Cancer1
Moderate Hepatic Impairment1
Lung Cancer (NSCLC)1
Lung Cancer (Non-Small Cell)1
Advanced Non-small-cell Lung Cancer1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
AstraZeneca8
Stemline Therapeutics, Inc.1
Relay Therapeutics, Inc.1
Aminex Therapeutics, Inc.1
Shanxi Province Cancer Hospital1
04

Trials by country register

A trial with sites in more than one country appears in each of those registers.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Capivasertib works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Capivasertib (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 24 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.