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Compound · clinical trials

Selumetinib clinical trials

Also listed in trial records as Koselugo
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 9 trials in our USA, UK and China registers that name Selumetinib as an intervention. Synced 25 Sep 2026
9Current trials
0Recruiting now
2Lead sponsors
3Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

Selumetinib is named as an intervention in 9 current clinical trials in our USA, UK and China registers. None are recruiting at the moment. The most common phase is Phase 1. The sponsor with the most trials is AstraZeneca (7). The most-studied condition is Neurofibromatosis Type 1.

Trials by status

  • Not yet open222%
  • Active, closed778%

Trials by phase

  • Phase 1333%
  • Phase 2333%
  • Phase 3222%
  • Phase 1/2111%
01

Clinical trials of Selumetinib

9 trials
StudyPhaseStatusLead sponsorRegisters
Selumetinib for NF2-Related Schwannomatosis
NCT07707947 · ClinicalTrials.gov ↗ · Neurofibromatosis Type 2, NF2, NF2-related Schwannomatosis
Phase 2 Not yet open Beijing Tiantan Hospital China
Platform Research for Innovative Medicines in NF2-SWN (PRIME-NF2)
NCT07713745 · ClinicalTrials.gov ↗ · Neurofibromatosis Type 2, Vestibular Schwannoma, Non-vestibular Schwannoma
Phase 2 Not yet open Beijing Tiantan Hospital China
Assess Efficacy & Safety of Selumetinib in Combination With Docetaxel in Patients Receiving 2nd Line Treatment for v-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Positive NSCLC
NCT01933932 · ClinicalTrials.gov ↗ · Locally Advanced or Metastatic Non Small Cell Lung Cancer Stage IIIb - IV
Phase 3 Active, closed AstraZeneca UK, USA
Efficacy and Safety of Selumetinib in Adults With NF1 Who Have Symptomatic, Inoperable Plexiform Neurofibromas
NCT04924608 · ClinicalTrials.gov ↗ · Neurofibromatosis 1, Plexiform Neurofibroma (PN)
Phase 3 Active, closed AstraZeneca UK, USA, China
Phase 2 Platform Study in Patients With Advanced Non-Small Lung Cancer Who Progressed on First-Line Osimertinib Therapy (ORCHARD)
NCT03944772 · Non-Small Cell Lung Cancer
Phase 2 Active, closed AstraZeneca USA
Pharmacokinetics, Safety and Efficacy of the Selumetinib Granule Formulation in Children Aged โ‰ฅ1 to <7 Years With NF1-related Symptomatic, Inoperable PN
NCT05309668 · ClinicalTrials.gov ↗ · Neurofibromatosis Type 1
Phase 1/2 Active, closed AstraZeneca USA
AZD9291 in Combination With Ascending Doses of Novel Therapeutics
NCT02143466 · ClinicalTrials.gov ↗ · Advanced Non Small Cell Lung Cancer
Phase 1 Active, closed AstraZeneca USA
Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Phase 1b Study in Pts w/ Muscle Invasive Bladder Cancer
NCT02546661 · ClinicalTrials.gov ↗ · Muscle Invasive Bladder Cancer
Phase 1 Active, closed AstraZeneca UK, USA
Phase I Study to Assess the Effect of Food on the PK and Gastrointestinal Tolerability of Selumetinib in Adolescent Children With Neurofibromatosis Type 1 Related Plexiform Neurofibromas
NCT05101148 · ClinicalTrials.gov ↗ · Neurofibromatosis Type 1
Phase 1 Active, closed AstraZeneca USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Selumetinib across our data

Ireland · EU · US

The same active substance in our other registers, matched by its exact name. Each entry links to the register record it comes from.

Licensed in Ireland (HPRA)

4 single-substance products containing Selumetinib on the HPRA medicines list.

All 4 Irish products →

Supply shortages

No entry for Selumetinib in the EMA, FDA or German BfArM shortage lists we track.

03

Conditions studied with Selumetinib

13 conditions
Neurofibromatosis Type 12Neurofibromatosis Type 22Meningioma2Neurofibromatosis 11Plexiform Neurofibroma (PN)1Muscle Invasive Bladder Cancer1Locally Advanced or Metastatic Non Small Cell Lung Cancer Stage IIIb - IV1Non-Small Cell Lung Cancer1Advanced Non Small Cell Lung Cancer1NF21NF2-related Schwannomatosis1Vestibular Schwannoma1
All 13 conditions
Condition (as registered)Trials
Neurofibromatosis Type 12
Neurofibromatosis Type 22
Meningioma2
Neurofibromatosis 11
Plexiform Neurofibroma (PN)1
Muscle Invasive Bladder Cancer1
Locally Advanced or Metastatic Non Small Cell Lung Cancer Stage IIIb - IV1
Non-Small Cell Lung Cancer1
Advanced Non Small Cell Lung Cancer1
NF21
NF2-related Schwannomatosis1
Vestibular Schwannoma1
Non-vestibular Schwannoma1
04

Sponsors

lead sponsor per trial
Lead sponsorTrials
AstraZeneca7
Beijing Tiantan Hospital2
05

By country register

RegisterTrialsRecruiting
Clinical trials in USA70
Clinical trials in UK30
Clinical trials in China30

A trial with sites in more than one country appears in each of those registers.

06

Related compounds

07

Questions about Selumetinib trials

How many clinical trials are testing Selumetinib?

9 current trials in our USA, UK and China registers name Selumetinib as a drug or biological intervention, as of the registry sync on 25 September 2026. Completed and withdrawn studies are not counted.

Are Selumetinib trials recruiting patients?

Not at the moment. None of the 9 trials in our registers is recruiting; they are active but closed to enrolment, not yet open, or enrolling by invitation. Only the study team can confirm whether a patient is eligible.

Who sponsors Selumetinib clinical trials?

AstraZeneca (7) and Beijing Tiantan Hospital (2). The number in brackets is how many trials each organisation leads.

Is Selumetinib licensed in Ireland?

Yes. The HPRA medicines list includes 4 single-substance products containing Selumetinib, for example Koselugo 10 mg hard capsules (AstraZeneca AB). A licence does not mean a product is currently marketed or reimbursed; see each product's record.

Is there a Selumetinib shortage?

Not in the lists we track: Selumetinib has no entry in the EMA, FDA or German BfArM shortage registers as of their latest sync.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Selumetinib works or whether it is effective, and it is not medical advice.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Selumetinib works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Selumetinib (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 25 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.