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Priya Life Science Compound trial record
Compound · clinical trials

Rilvegostomig clinical trials

Also listed in trial records as AZD2936, AZD8205 and AZD2936, AZD8205 and AZD5305 (saruparib) and AZD2936, Other Name: AZD2936
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 34 trials in our USA, Spain, South Korea, Taiwan, Japan, China, Italy, Canada, UK, France, Poland, Belgium, Turkey, Brazil, Australia, Germany, Netherlands, India, Austria, Switzerland, Denmark, Singapore, Ireland, Portugal, Israel, Norway, Sweden and Czechia registers that name Rilvegostomig as an intervention. Synced 9 Nov 2026
34Current trials
24Recruiting now
6Lead sponsors
28Country registers
At a glance

Rilvegostomig is named as an intervention in 34 current clinical trials in our USA, Spain, South Korea, Taiwan, Japan, China, Italy, Canada, UK, France, Poland, Belgium, Turkey, Brazil, Australia, Germany, Netherlands, India, Austria, Switzerland, Denmark, Singapore, Ireland, Portugal, Israel, Norway, Sweden and Czechia registers. 24 are recruiting patients now. The most common phase is Phase 3. The sponsor with the most trials is AstraZeneca (29). The most-studied condition is Gastric Cancer. The EU clinical trials register (CTIS) separately lists 4 authorised or ongoing trials.

How Rilvegostomig works

All drug targets →
Diseases it has been tested for in clinical trials, by furthest phase
  • Biliary tract cancerPhase 3
  • Endometrial cancerPhase 3
  • Esophageal adenocarcinomaPhase 3
  • Gastric adenocarcinomaPhase 3
  • Gastroesophageal junction adenocarcinomaPhase 3
  • Hepatocellular carcinomaPhase 3
  • Non-small cell lung carcinomaPhase 3
  • CancerPhase 2
  • Colorectal cancerPhase 2
  • Colorectal carcinomaPhase 2
21 diseases in all

Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL5314706, CC BY-SA 3.0. The Guide to Pharmacology has no record of this medicine, so its targets rest on ChEMBL alone. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.

Patient leaflets for Rilvegostomig

The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.

  • UK
    United Kingdom: Search MHRA Products
    Patient information leaflets and SmPCs for UK-licensed products.
  • US
    United States: Search DailyMed
    FDA-approved labels, including patient and medication guides.

Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.

Trials by status

  • Recruiting2471%
  • Not yet open26%
  • Active, closed824%

Trials by phase

  • Phase 31338%
  • Phase 21132%
  • Phase 1/2515%
  • Phase 1412%
  • Early Phase 113%
01

Clinical trials of Rilvegostomig

34 trials
StudyPhaseStatusLead sponsorRegisters
Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations
NCT06357533 · Non-Small Cell Lung Cancer
Phase 3 Recruiting AstraZeneca UK, USA, India, China, Germany, Spain, Italy, Belgium, Poland, Austria, Turkey, Canada, Brazil, Japan, South Korea, Taiwan, Australia
Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer
NCT06467357 · Biliary Tract Cancer
Phase 3 Recruiting AstraZeneca UK, USA, India, China, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Austria, Czechia, Turkey, Canada, Brazil, Japan, South Korea, Taiwan, Australia
A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Non-Squamous NSCLC
NCT06627647 · Non-squamous Non-small Cell Lung Cancer
Phase 3 Recruiting AstraZeneca UK, USA, India, China, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Turkey, Canada, Brazil, Japan, South Korea, Taiwan, Australia
A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)
NCT06692738 · Non-small Cell Lung Cancer
Phase 3 Recruiting AstraZeneca UK, USA, India, China, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Austria, Turkey, Canada, Brazil, Japan, South Korea, Taiwan, Australia
A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer
NCT06764875 · HER2-positive Gastric Cancer, Gastroesophageal Junction Adenocarcinoma
Phase 3 Recruiting AstraZeneca UK, USA, India, China, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Austria, Turkey, Canada, Brazil, Japan, South Korea, Taiwan, Australia
A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer
NCT06868277 · Carcinoma, Non-Small Cell Lung
Phase 3 Recruiting AstraZeneca Ireland, UK, USA, China, Germany, France, Spain, Italy, Belgium, Switzerland, Portugal, Turkey, Canada, Brazil, Japan, South Korea, Australia, Israel
Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma
NCT06921785 · Hepatocellular Carcinoma
Phase 3 Recruiting AstraZeneca UK, USA, India, China, Germany, France, Spain, Italy, Netherlands, Poland, Turkey, Canada, Brazil, Japan, South Korea, Taiwan, Australia
DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer
NCT06989112 · Endometrial Cancer
Phase 3 Recruiting AstraZeneca UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Sweden, Denmark, Poland, Switzerland, Austria, Norway, Canada, Brazil, Japan, South Korea, Taiwan, Australia
A Study of Rilvegostomig or Durvalumab Plus Chemotherapy for First-Line Treatment of Biliary Tract Cancer (ARTEMIDE-Biliary02)
NCT07221253 · Biliary Tract Cancer
Phase 3 Recruiting AstraZeneca UK, USA, India, China, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Turkey, Canada, Brazil, Japan, South Korea, Taiwan, Australia
Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2
NCT07431281 · Gastric Cancer, Gastroesophageal Junction Adenocarcinoma, Esophageal Cancer
Phase 3 Recruiting AstraZeneca UK, USA, India, China, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Austria, Turkey, Canada, Brazil, Japan, South Korea, Taiwan, Australia
An Open-label Study to Investigate the Efficacy and Safety of Dato-DXd + Rilvegostomig vs SoC in Adult Participants With High-risk MIUC
NCT07720284 · High-risk Muscle Invasive Urothelial Carcinoma
Phase 3 Recruiting AstraZeneca UK, USA, India, China, Germany, France, Spain, Italy, Poland, Canada, Brazil, Japan, South Korea, Taiwan, Australia
Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer
NCT05061550 · Non-small Cell Lung Cancer
Phase 2 Recruiting AstraZeneca Ireland, USA, France, Spain, Italy, Belgium, Portugal, Turkey, Canada, South Korea, Taiwan
Molecular Residual Disease Interception in Locoregionally-Advanced High Risk HPV+ and HPV- HNSCC
NCT05414032 · ClinicalTrials.gov ↗ · Locoregionally Advanced Head and Neck Squamous Cell Carcinoma (LA-HNSCC)
Phase 2 Recruiting University Health Network, Toronto Canada
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
NCT05489211 · Endometrial Cancer, Gastric Cancer, Metastatic Castration-resistant Prostate Cancer
Phase 2 Recruiting AstraZeneca UK, USA, China, Germany, France, Spain, Italy, Poland, Switzerland, Turkey, Canada, Japan, South Korea, Taiwan
Novel Combinations in Participants With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma
NCT05702229 · Gastric Cancer
Phase 2 Recruiting AstraZeneca UK, USA, China, Spain, Japan, South Korea, Taiwan
Perioperative Therapies in Locally Advanced Unresectable Gastric Cancer
NCT06630130 · ClinicalTrials.gov ↗ · Stomach Neoplasms
Phase 2 Recruiting Jeeyun Lee South Korea
A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma
NCT07069712 · Gastroesophageal Adenocarcinoma
Phase 2 Recruiting AstraZeneca UK, USA, China, Spain, Italy, Poland, Turkey, Canada, Japan, Taiwan
A Study of Novel Combinations in Non-Small Cell Lung Cancer (NSCLC)
NCT07098338 · Non-Small Cell Lung Cancer
Phase 2 Recruiting AstraZeneca USA, China, France, Spain, Italy, Canada, Japan, South Korea, Taiwan, Singapore, Australia
A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies
NCT05123482 · Breast Cancer, Biliary Tract Carcinoma, Ovarian Cancer
Phase 1/2 Recruiting AstraZeneca UK, USA, China, Spain, Italy, Netherlands, Belgium, Poland, Canada, Japan, South Korea, Taiwan, Australia
Study of AZD5863 in Adult Participants With Advanced or Metastatic Solid Tumors
NCT06005493 · Gastric Cancer, Gastro-esophageal Junction Cancer, Pancreatic Ductal Adenocarcinoma
Phase 1/2 Recruiting AstraZeneca UK, USA, China, France, Netherlands, Japan, South Korea, Taiwan
A Platform Study in Non-Small Cell Lung Cancer (NSCLC)
NCT06996782 · Advanced or Metastatic Non-small Cell Lung Cancer
Phase 1/2 Recruiting AstraZeneca USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Turkey, Brazil, Japan, South Korea, Taiwan, Singapore
A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors
NCT07115043 · ClinicalTrials.gov ↗ · Melanoma, Non-small Cell Lung Cancer, Squamous Cell Carcinoma (Skin)
Phase 1/2 Recruiting AstraZeneca USA, Japan, South Korea, Australia
Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC
NCT04686305 · Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Phase 1 Recruiting AstraZeneca USA, China, France, Spain, Italy, Netherlands, Belgium, Poland, Turkey, Canada, Brazil, South Korea, Taiwan, Singapore, Australia, Israel
A Study to Investigate the Pharmacokinetics and Safety of Subcutaneous Rilvegostomig in Adult Participants With Advanced Solid Tumors Previously Treated With Standard of Care Therapy
NCT07161414 · Advanced Solid Tumors
Phase 1 Recruiting AstraZeneca UK, USA, Spain, South Korea
PErioperative CISGEM + Rilvegostomig in High-Risk Resectable Intra Hepatic CholangioCarcinoma
NCT07128290 · ClinicalTrials.gov ↗ · Intrahepatic Cholangiocarcinoma (Icc)
Phase 2 Not yet open Federation Francophone de Cancerologie Digestive France
Local and Systemic Immune Modulation by Rilvegostomig (AZD2936) in the Treatment of Advanced Gastric Cancer (RILVE Project)
NCT07788664 · Advanced Gastric Cancer
Phase 2 Not yet open Vall d'Hebron Institute of Oncology Spain
Rilvegostomig + Chemotherapy as Adjuvant Therapy for Biliary Tract Cancer After Resection (ARTEMIDE-Biliary01)
NCT06109779 · Biliary Tract Cancer
Phase 3 Active, closed AstraZeneca UK, USA, India, China, Germany, France, Spain, Italy, Belgium, Denmark, Poland, Norway, Turkey, Canada, Brazil, Japan, South Korea, Taiwan, Australia
A Phase III, Randomised Study of Adjuvant Dato-DXd in Combination With Rilvegostomig or Rilvegostomig Monotherapy Versus Standard of Care, Following Complete Tumour Resection, in Participants With Stage I Adenocarcinoma NSCLC Who Are ctDNA-positive or Have High-risk Pathological Features
NCT06564844 · Non-small Cell Lung Cancer
Phase 3 Active, closed AstraZeneca USA, Turkey, Canada, Brazil, Japan, Taiwan
Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)
NCT04379596 · Gastric Cancer
Phase 2 Active, closed AstraZeneca UK, USA, China, Germany, Spain, Italy, Netherlands, Poland, Canada, Brazil, Japan, South Korea, Taiwan
Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer
NCT05775159 · Hepatocellular Carcinoma, Biliary Tract Cancer
Phase 2 Active, closed AstraZeneca UK, USA, China, Spain, Italy, Japan, South Korea, Taiwan
A Study of AZD2936 Anti-TIGIT/Anti-PD-1 Bispecific Antibody in Participants With Advanced or Metastatic NSCLC
NCT04995523 · Non-Small-Cell Lung Carcinoma
Phase 1/2 Active, closed AstraZeneca USA, China, France, Spain, Netherlands, Belgium, Denmark, Brazil, Japan, South Korea, Taiwan, Australia
A Study of Novel Anti-cancer Agents in Patients With Previously Untreated NSCLC
NCT03819465 · Metastatic Non-Small Cell Lung Cancer (NSCLC)
Phase 1 Active, closed AstraZeneca USA, Spain, Belgium, Poland, Austria, South Korea, Taiwan
Phase 1b Study of Dato-DXd in Combination With Immunotherapy With or Without Carboplatin in Advanced or Metastatic Non-Small Cell Lung Cancer
NCT04612751 · Advanced or Metastatic NSCLC
Phase 1 Active, closed AstraZeneca USA, Spain, Italy, Belgium, Poland, Turkey, Japan, Taiwan
Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies
NCT04541108 · Solid Tumor
Early Phase 1 Active, closed Presage Biosciences USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Rilvegostomig in the EU trials register (CTIS)

4 trials

Authorised or ongoing trials in the EU Clinical Trials Information System that list a product containing Rilvegostomig. Many trials are registered in both CTIS and ClinicalTrials.gov, so these are shown separately rather than added to the count above. Trials with a site in Ireland are listed first.

StudyPhaseStatusSponsorCountries
A Phase III, Open-Label, Randomised, Multicentre, Global Study of Adjuvant Datopotamab Deruxtecan in Combination With Rilvegostomig in Participants With High-risk Muscle Invasive Urothelial Carcinoma (TROPION-Urothelial04).
2025-525030-57-00 · Neoplasms
Phase 3 Ongoing AstraZeneca AB Italy, Poland, Spain + 2 more
Local and systemic immune modulation by Rilvegostomig (AZD2936) in the treatment of advanced gastric cancer (RILVE Project)
2026-525620-23-00 · Neoplasms
Phase 2 Authorised Vall D Hebron Institute Of Oncology Spain
A Master Protocol of a Phase II, Open-label, Multicenter, Global Platform Study to Evaluate the Safety and Efficacy of Immunotherapy With or Without Other Anticancer Drugs in Participants with Unresectable Stage III Non-small Cell Lung Cancer Planning to Undergo Concurrent Chemoradiotherapy (AQUARIUS)
2025-523599-21-00 · Neoplasms
Phase 2 Authorised AstraZeneca AB Spain, Germany
A Phase Ib/II Open-Label, Multicentre Platform Study Evaluating Novel Combinations in Participants with Advanced or Metastatic Non-Small Cell Lung Cancer (ALTAIR)
2024-519786-22-01 · CTIS ↗ · Neoplasms
Phase 1 Ongoing AstraZeneca AB Germany, Spain, France + 4 more
03

Conditions studied with Rilvegostomig

34 conditions
All 34 conditions
Condition (as registered)Trials
Gastric Cancer5
Non-small Cell Lung Cancer4
Biliary Tract Cancer4
Endometrial Cancer3
Hepatocellular Carcinoma2
Ovarian Cancer2
Non-Small Cell Lung Cancer2
Gastroesophageal Junction Adenocarcinoma2
Carcinoma, Non-Small Cell Lung1
Breast Cancer1
Biliary Tract Carcinoma1
High-risk Muscle Invasive Urothelial Carcinoma1
Esophageal Cancer1
Gastro-esophageal Junction Cancer1
Pancreatic Ductal Adenocarcinoma1
Esophageal Adenocarcinoma1
Metastatic Castration-resistant Prostate Cancer1
HER2-positive Gastric Cancer1
Advanced Solid Tumors1
Non-squamous Non-small Cell Lung Cancer1
Gastroesophageal Adenocarcinoma1
Melanoma1
Squamous Cell Carcinoma (Skin)1
Renal Cell Carcinoma1
Locally Advanced or Metastatic Non-Small Cell Lung Cancer1
Non-Small-Cell Lung Carcinoma1
Advanced or Metastatic NSCLC1
Advanced or Metastatic Non-small Cell Lung Cancer1
Solid Tumor1
Intrahepatic Cholangiocarcinoma (Icc)1
Advanced Gastric Cancer1
Stomach Neoplasms1
Metastatic Non-Small Cell Lung Cancer (NSCLC)1
Locoregionally Advanced Head and Neck Squamous Cell Carcinoma (LA-HNSCC)1
06

Related compounds

07

Questions about Rilvegostomig trials

How many clinical trials are testing Rilvegostomig?

34 current trials in our USA, Spain, South Korea, Taiwan, Japan, China, Italy, Canada, UK, France, Poland, Belgium, Turkey, Brazil, Australia, Germany, Netherlands, India, Austria, Switzerland, Denmark, Singapore, Ireland, Portugal, Israel, Norway, Sweden and Czechia registers name Rilvegostomig (also registered as AZD2936) as a drug or biological intervention, as of the registry sync on 9 November 2026. Completed and withdrawn studies are not counted.

Are Rilvegostomig trials recruiting patients?

Yes. 24 of the 34 trials are recruiting: 22 with sites in USA, 20 with sites in Spain, 22 with sites in South Korea, 19 with sites in Taiwan, 19 with sites in Japan, 19 with sites in China, 18 with sites in Italy, 18 with sites in Canada, 17 with sites in UK, 16 with sites in France, 15 with sites in Poland, 13 with sites in Belgium, 14 with sites in Turkey, 13 with sites in Brazil, 15 with sites in Australia, 13 with sites in Germany, 12 with sites in Netherlands, 9 with sites in India, 6 with sites in Austria, 3 with sites in Switzerland, 1 with sites in Denmark, 3 with sites in Singapore, 2 with sites in Ireland, 2 with sites in Portugal, 2 with sites in Israel, 1 with sites in Norway, 1 with sites in Sweden and 1 with sites in Czechia. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Rilvegostomig clinical trials?

AstraZeneca (29), Presage Biosciences (1), Federation Francophone de Cancerologie Digestive (1) and Vall d'Hebron Institute of Oncology (1), among 6 lead sponsors in total. The number in brackets is how many trials each organisation leads.

Are there Rilvegostomig clinical trials in Ireland?

Yes. 2 trials in our Ireland register (ClinicalTrials.gov). Some may be the same study registered in both. See the Irish clinical trials register for sites and contacts.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Rilvegostomig works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Rilvegostomig works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Rilvegostomig (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 9 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.