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Compound · clinical trials

Berobenatide clinical trials

Also listed in trial records as MET097, PF-08653944
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 11 trials in our USA, Canada, Japan, UK, Germany, Spain, Poland, Czechia, Brazil, South Korea and China registers that name Berobenatide as an intervention. Synced 27 Sep 2026
11Current trials
3Recruiting now
1Lead sponsor
11Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

Berobenatide is named as an intervention in 11 current clinical trials in our USA, Canada, Japan, UK, Germany, Spain, Poland, Czechia, Brazil, South Korea and China registers. 3 are recruiting patients now. The most common phase is Phase 3. The lead sponsor is Pfizer. The most-studied condition is Obesity. The EU clinical trials register (CTIS) separately lists 3 authorised or ongoing trials.

Trials by status

  • Recruiting327%
  • Not yet open327%
  • Active, closed545%

Trials by phase

  • Phase 3655%
  • Phase 2218%
  • Phase 1218%
  • Phase 1/219%
01

Clinical trials of Berobenatide

11 trials
StudyPhaseStatusLead sponsorRegisters
A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity
NCT07595549 · ClinicalTrials.gov ↗ · Obesity, Overweight and/or Obesity, Overweight
Phase 3 Recruiting Pfizer USA, Canada, Brazil, Japan, South Korea
A Study of MET233 in Combination With MET097 in Individuals With Obesity or Overweight With or Without Diabetes
NCT06924320 · ClinicalTrials.gov ↗ · Obesity and Obesity-related Medical Conditions
Phase 1/2 Recruiting Pfizer USA
A Study to Learn About the Medicine Called PF-08653944 in People With and Without Reduced Liver Function
NCT07519135 · ClinicalTrials.gov ↗ · Healthy
Phase 1 Recruiting Pfizer USA
A Study to Learn About the Study Medicine Called PF-08653944 Taken Once-Weekly Compared to Placebo in Chinese Adults With Overweight or Obesity
NCT07792954 · ClinicalTrials.gov ↗ · Obesity, Overweight
Phase 3 Not yet open Pfizer China
A Study to Learn About Safety and Effects of Once-weekly Treatment With Berobenatide in Adults With Obesity Disease in Japan (VESPER-JW)
NCT07794761 · ClinicalTrials.gov ↗ · Obesity
Phase 3 Not yet open Pfizer Japan
A Study to Learn About Safety and Effects of Once-monthly Treatment With Berobenatide in Adults With Obesity Disease in Japan (VESPER-JM)
NCT07794774 · ClinicalTrials.gov ↗ · Obesity
Phase 3 Not yet open Pfizer Japan
Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity
NCT07311850 · ClinicalTrials.gov ↗ · Obesity and Overweight
Phase 3 Active, closed Pfizer UK, USA, Germany, Spain, Poland, Czechia, Canada
A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)
NCT07400653 · ClinicalTrials.gov ↗ · Obesity, Overweight and/or Obesity, Overweight
Phase 3 Active, closed Pfizer UK, USA, Germany, Spain, Poland, Czechia, Canada
A Phase 2b Study to Evaluate the Efficacy and Safety of Once-Monthly MET097 in Adults With Obesity or Overweight
NCT06973720 · ClinicalTrials.gov ↗ · Obesity, Overweight or Obesity
Phase 2 Active, closed Pfizer USA
A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity
NCT07575932 · ClinicalTrials.gov ↗ · Overweight, Obesity, Overweight and/or Obesity
Phase 2 Active, closed Pfizer USA, Canada
A Study to Learn About the Effect of Study Medicine Called PF-08653944 on How Quickly the Stomach Empties Its Content in Healthy Adults With Overweight or Obesity
NCT07508241 · ClinicalTrials.gov ↗ · Obesity, Overweight and/or Obesity, Overweight
Phase 1 Active, closed Pfizer USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Berobenatide in the EU trials register (CTIS)

3 trials

Authorised or ongoing trials in the EU Clinical Trials Information System that list a product containing Berobenatide. Many trials are registered in both CTIS and ClinicalTrials.gov, so these are shown separately rather than added to the count above. Trials with a site in Ireland are listed first.

StudyPhaseStatusSponsorCountries
C6491013 - A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Once-Monthly PF-08653944 in Adults with Overweight or Obesity (VESPER 6)
2026-525318-75-00 · Nutritional and Metabolic Diseases
Phase 3 Authorised Pfizer Inc Spain, France, Germany + 2 more
EVALUATING THE EFFICACY AND SAFETY OF MET097, A FULLY- BIASED ULTRA LONG-ACTING GLP-1 RA IN PEOPLE WITH OVERWEIGHT OR OBESITY AND TYPE 2 DIABETES: A PHASE 3, MULTI-CENTER RANDOMIZED PLACEBO-CONTROLLED TRIAL (VESPER-5)
2025-523975-48-00 · CTIS ↗ · Nutritional and Metabolic Diseases
Phase 3 Ongoing Metsera Inc Czechia, Bulgaria, Slovakia + 5 more
EVALUATING THE EFFICACY AND SAFETY OF MET097, A FULLY- BIASED ULTRA LONG-ACTING GLP-1RA IN PEOPLE WITH OVERWEIGHT OR OBESITY: A PHASE 3, MULTI-CENTER RANDOMIZED, CONTROLLED TRIAL (VESPER-4)
2025-523974-18-00 · CTIS ↗ · Nutritional and Metabolic Diseases
Phase 3 Ongoing Metsera Inc Germany, Hungary, Slovakia + 5 more
03

Conditions studied with Berobenatide

9 conditions
Obesity8Overweight5Overweight and/or Obesity4Overweight or Obesity2Obesity and Overweight1Diabetes, Type 21Obesity and Obesity-related Medical Conditions1Healthy1Drug Interaction1
04

Sponsors

lead sponsor per trial
Lead sponsorTrials
Pfizer11
05

By country register

RegisterTrialsRecruiting
Clinical trials in USA83
Clinical trials in Canada41
Clinical trials in Japan31
Clinical trials in UK20
Clinical trials in Germany20
Clinical trials in Spain20
Clinical trials in Poland20
Clinical trials in Czechia20
Clinical trials in Brazil11
Clinical trials in South Korea11
Clinical trials in China10
EU register (CTIS)3—

A trial with sites in more than one country appears in each of those registers. CTIS does not publish a recruiting flag; its trials may also appear in the registers above.

06

Related compounds

07

Questions about Berobenatide trials

How many clinical trials are testing Berobenatide?

11 current trials in our USA, Canada, Japan, UK, Germany, Spain, Poland, Czechia, Brazil, South Korea and China registers name Berobenatide (also registered as MET097) as a drug or biological intervention, as of the registry sync on 27 September 2026. Completed and withdrawn studies are not counted.

Are Berobenatide trials recruiting patients?

Yes. 3 of the 11 trials are recruiting: 3 with sites in USA, 1 with sites in Canada, 1 with sites in Japan, 1 with sites in Brazil and 1 with sites in South Korea. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Berobenatide clinical trials?

The lead sponsor is Pfizer. The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Berobenatide works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Berobenatide works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Berobenatide (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 27 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.