Ireland
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Priya Life Science Compound trial record
Compound · clinical trials

Retatrutide clinical trials

Also listed in trial records as LY3437943
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 11 trials in our USA, Canada, UK, Germany, Poland, Mexico, Brazil, Israel, India, France, Spain, Italy, Netherlands, Belgium, Austria, Czechia, Turkey, Australia, China, Denmark, Sweden, Switzerland, Norway, Portugal, Japan, South Korea and Taiwan registers that name Retatrutide as an intervention. Synced 9 Nov 2026
11Current trials
2Recruiting now
2Lead sponsors
27Country registers
At a glance

Retatrutide is named as an intervention in 11 current clinical trials in our USA, Canada, UK, Germany, Poland, Mexico, Brazil, Israel, India, France, Spain, Italy, Netherlands, Belgium, Austria, Czechia, Turkey, Australia, China, Denmark, Sweden, Switzerland, Norway, Portugal, Japan, South Korea and Taiwan registers. 2 are recruiting patients now. The most common phase is Phase 3. The sponsor with the most trials is Eli Lilly and Company (10). The most-studied condition is Obesity.

How Retatrutide works

All drug targets →
  • Glucagon receptor agonist Agonist
    Target: GCGR glucagon receptor
    ✓ In ChEMBL and the Guide to Pharmacology
  • Glucagon-like peptide 1 receptor agonist Agonist
    Target: GLP1R glucagon like peptide 1 receptor
    ✓ In ChEMBL and the Guide to Pharmacology
  • Gastric inhibitory polypeptide receptor agonist Agonist
    Target: GIPR gastric inhibitory polypeptide receptor
    ✓ In ChEMBL and the Guide to Pharmacology
Other medicines acting on GCGR
Other medicines acting on GIPR
Diseases it has been tested for in clinical trials, by furthest phase
  • OverweightPhase 3
  • Cardiovascular disorderPhase 3
  • Obesity disorderPhase 3
  • OsteoarthritisPhase 3
  • Type 2 diabetes mellitusPhase 3
  • Chronic kidney diseasePhase 2
  • HypoglycemiaPhase 1

Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL5095485, CC BY-SA 3.0. Targets checked against the IUPHAR/BPS Guide to PHARMACOLOGY (2026.3.1), ligand 13769, CC BY-SA 4.0. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.

Patient leaflets for Retatrutide

The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.

  • UK
    United Kingdom: Search MHRA Products
    Patient information leaflets and SmPCs for UK-licensed products.
  • US
    United States: Search DailyMed
    FDA-approved labels, including patient and medication guides.

Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.

Reference identifiers for Retatrutide

ChEMBL
CHEMBL5095485
FDA UNII
NOP2Y096GV
Wikidata
Q120468350
Wikipedia
Retatrutide

Codes that identify this medicine in other databases, from Wikidata (CC0), matched by its ChEMBL ID. The ATC code is the WHO classification of what the medicine is used for.

Trials by status

  • Recruiting218%
  • Active, closed982%

Trials by phase

  • Phase 3982%
  • Phase 219%
  • Phase 119%
01

Clinical trials of Retatrutide

11 trials
StudyPhaseStatusLead sponsorRegisters
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)
NCT07165028 · Metabolic Dysfunction-Associated Steatotic Liver Disease
Phase 3 Recruiting Eli Lilly and Company UK, USA, India, China, Germany, France, Spain, Italy, Netherlands, Belgium, Sweden, Poland, Switzerland, Austria, Czechia, Norway, Portugal, Turkey, Canada, Brazil, Mexico, Japan, South Korea, Taiwan, Australia, Israel
Effect of LY3437943 Versus Placebo in Participants Who Have Obesity or Are Overweight
NCT07467447 · ClinicalTrials.gov ↗ · Obesity
Phase 2 Recruiting Hudson Biotech China
Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)
NCT06260722 · Diabetes Mellitus, Type 2
Phase 3 Active, closed Eli Lilly and Company USA, Canada, Mexico
Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)
NCT06297603 · Type 2 Diabetes
Phase 3 Active, closed Eli Lilly and Company UK, USA, Brazil, Mexico, Israel
The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
NCT06383390 · Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
Phase 3 Active, closed Eli Lilly and Company UK, USA, India, Germany, France, Spain, Italy, Netherlands, Belgium, Denmark, Poland, Austria, Czechia, Turkey, Canada, Brazil, Mexico, Australia, Israel
A Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have Obesity
NCT06662383 · ClinicalTrials.gov ↗ · Obesity
Phase 3 Active, closed Eli Lilly and Company USA, Germany, Poland
A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With Obesity
NCT06859268 · Obesity
Phase 3 Active, closed Eli Lilly and Company UK, USA, Canada
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain
NCT07035093 · ClinicalTrials.gov ↗ · Obesity, Overweight, Chronic Low Back Pain (CLBP)
Phase 3 Active, closed Eli Lilly and Company USA, Poland, Canada
A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight
NCT07232719 · Obesity, Overweight
Phase 3 Active, closed Eli Lilly and Company UK, USA
A Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or Overweight
NCT07357415 · Obesity, Overweight
Phase 3 Active, closed Eli Lilly and Company USA, Canada
A Study to Evaluate the Effect of Retatrutide on Insulin Secretion and Insulin Sensitivity in Adult Participants With Type 2 Diabetes Mellitus
NCT06982859 · ClinicalTrials.gov ↗ · Diabetes Mellitus, Insulin Sensitivity
Phase 1 Active, closed Eli Lilly and Company Germany

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Retatrutide

10 conditions
Obesity6Overweight3Atherosclerotic Cardiovascular Disease (ASCVD)1Chronic Kidney Disease (CKD)1Type 2 Diabetes1Metabolic Dysfunction-Associated Steatotic Liver Disease1Diabetes Mellitus, Type 21Chronic Low Back Pain (CLBP)1Diabetes Mellitus1Insulin Sensitivity1
05

Related compounds

06

Questions about Retatrutide trials

How many clinical trials are testing Retatrutide?

11 current trials in our USA, Canada, UK, Germany, Poland, Mexico, Brazil, Israel, India, France, Spain, Italy, Netherlands, Belgium, Austria, Czechia, Turkey, Australia, China, Denmark, Sweden, Switzerland, Norway, Portugal, Japan, South Korea and Taiwan registers name Retatrutide (also registered as LY3437943) as a drug or biological intervention, as of the registry sync on 9 November 2026. Completed and withdrawn studies are not counted.

Are Retatrutide trials recruiting patients?

Yes. 2 of the 11 trials are recruiting: 1 with sites in USA, 1 with sites in Canada, 1 with sites in UK, 1 with sites in Germany, 1 with sites in Poland, 1 with sites in Mexico, 1 with sites in Brazil, 1 with sites in Israel, 1 with sites in India, 1 with sites in France, 1 with sites in Spain, 1 with sites in Italy, 1 with sites in Netherlands, 1 with sites in Belgium, 1 with sites in Austria, 1 with sites in Czechia, 1 with sites in Turkey, 1 with sites in Australia, 2 with sites in China, 1 with sites in Sweden, 1 with sites in Switzerland, 1 with sites in Norway, 1 with sites in Portugal, 1 with sites in Japan, 1 with sites in South Korea and 1 with sites in Taiwan. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Retatrutide clinical trials?

Eli Lilly and Company (10) and Hudson Biotech (1). The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Retatrutide works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Retatrutide works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Retatrutide (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 9 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.