Conversion Therapy of RAS/BRAF Wild-Type Colorectal Cancer Patients With Initially Unresectable Liver Metastases
NCT04687631 · ClinicalTrials.gov ↗ · Colorectal Cancer, Liver Metastases
|
Phase 3 |
Recruiting |
Fudan University |
China |
JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC
NCT04892173 · ClinicalTrials.gov ↗ · Carcinoma, Squamous Cell
|
Phase 3 |
Recruiting |
Johnson & Johnson Enterprise Innovation Inc. |
UK, USA, India, China |
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
NCT05253651 · ClinicalTrials.gov ↗ · Colorectal Neoplasms
|
Phase 3 |
Recruiting |
Seagen, a wholly owned subsidiary of Pfizer |
Ireland, UK, USA, China |
A Study to Evaluate MRG003 vs Cetuximab/Methotrexate in in the Treatment of Patients With RM-SCCHN
NCT05751512 · ClinicalTrials.gov ↗ · Squamous Cell Carcinoma of the Head and Neck
|
Phase 3 |
Recruiting |
Lepu Biopharma Co., Ltd. |
China |
A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma
NCT06064877 · ClinicalTrials.gov ↗ · Metastatic Head-and-neck Squamous-cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma
|
Phase 3 |
Recruiting |
AVEO Pharmaceuticals, Inc. |
UK, USA, China |
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
NCT06662786 · ClinicalTrials.gov ↗ · Colorectal Neoplasms
|
Phase 3 |
Recruiting |
Janssen Research & Development, LLC |
UK, USA, India, China |
|
A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
|
Phase 3 |
Recruiting |
Janssen Research & Development, LLC |
UK, USA, India, China |
Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)
NCT06881784 · NSCLC (Non-small Cell Lung Cancer), Non-Small Cell Lung Cancer, NSCLC
|
Phase 3 |
Recruiting |
Revolution Medicines, Inc. |
Ireland, UK, USA |
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
NCT06997497 · ClinicalTrials.gov ↗ · Colon Adenocarcinoma, Rectal Adenocarcinoma
|
Phase 3 |
Recruiting |
Merck Sharp & Dohme LLC |
UK, USA, China |
Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)
NCT07252232 · ClinicalTrials.gov ↗ · Pancreatic Cancer, PDAC, PDAC - Pancreatic Ductal Adenocarcinoma
|
Phase 3 |
Recruiting |
Revolution Medicines, Inc. |
UK, USA |
Phase III Study to Compare GFH375 and Chemotherapy in Patients With KRAS G12D-Mutant Metastatic Pancreatic Cancer
NCT07262567 · ClinicalTrials.gov ↗ · Metastatic Pancreatic Cancer
|
Phase 3 |
Recruiting |
Genfleet Therapeutics (Shanghai) Inc. |
China |
Study of Daraxonrasib and Daraxonrasib + GnP as First-line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma
NCT07491445 · ClinicalTrials.gov ↗ · Pancreatic Cancer, Pancreatic Cancer Metastatic, PDAC
|
Phase 3 |
Recruiting |
Revolution Medicines, Inc. |
UK, USA, China |
SCRT + Chemo Targeted Immuno-neoadjuvant Therapy for High-risk pMMR/MSS RC
NCT07549399 · ClinicalTrials.gov ↗ · Rectal Adenocarcinoma, High-Risk Cancer, MSS
|
Phase 3 |
Recruiting |
Sixth Affiliated Hospital, Sun Yat-sen University |
China |
A Study to Evaluate GFH375 Versus Docetaxel in Participants With Non-Small Cell Lung Cancer With KRAS G12D Mutation
NCT07668752 · ClinicalTrials.gov ↗ · KRAS G12D Mutation, NSCLC (Non-small Cell Lung Cancer)
|
Phase 3 |
Recruiting |
Genfleet Therapeutics (Shanghai) Inc. |
China |
|
Study of Petosemtamab Plus Chemotherapy Versus Cetuximab Plus Chemotherapy in RAS and BRAF Wild-type, Unresectable or Metastatic, Left-sided Colorectal Cancer (LiGeR-CRC1)
|
Phase 3 |
Recruiting |
Genmab |
USA |
Study of Zoldonrasib (RMC-9805) Plus Daraxonrasib (RMC-6236) Versus Gemcitabine and Nab-Paclitaxel as First-Line Treatment in Metastatic KRAS G12D-Mutated Pancreatic Adenocarcinoma
NCT07805954 · Pancreatic Cancer, Pancreatic Cancer Metastatic, PDAC
|
Phase 3 |
Recruiting |
Revolution Medicines, Inc. |
USA |
Penpulimab in Combination With Cetuximab as First-line Treatment in R/M SCCHN
NCT05260671 · ClinicalTrials.gov ↗ · Head and Neck Neoplasms, Recurrent Disease, Metastatic Cancer
|
Phase 2 |
Recruiting |
Eye & ENT Hospital of Fudan University |
China |
The Combination of Hypofractionated Radiotherapy and Immunotherapy in Locally Recurrent Rectal Cancer
NCT05628038 · ClinicalTrials.gov ↗ · Recurrent Rectal Cancer
|
Phase 2 |
Recruiting |
Fudan University |
China |
Neoadjuvant PD-1 Inhibitor Combined With Cetuximab and Platinum in Resectable Locally Advanced Hypopharyngeal Carcinoma
NCT06151743 · ClinicalTrials.gov ↗ · Locally Advanced Hypopharyngeal Carcinoma
|
Phase 2 |
Recruiting |
Eye & ENT Hospital of Fudan University |
China |
Neoadjuvant SBRT in Localized Advanced HNSCC
NCT06306846 · ClinicalTrials.gov ↗ · Head and Neck Squamous Carcinoma
|
Phase 2 |
Recruiting |
Jiang Feng |
China |
Clinical Study of Second-line Treatment in Advanced Colorectal Cancer With Chemotherapy With Bevacizumab or Cetuximab
NCT06540326 · ClinicalTrials.gov ↗ · Colorectal Cancer Metastatic
|
Phase 2 |
Recruiting |
Second Affiliated Hospital, Zhejiang University, School of Medicine |
China |
Cetuximab, Irinotecan, Toripalimab in RAS/BRAF Wild-type Ultraselected Right-sided Colorectal Cancer Study
NCT06547203 · ClinicalTrials.gov ↗ · Colorectal Cancer Metastatic
|
Phase 2 |
Recruiting |
Sun Yat-sen University |
China |
A Study on the Efficacy and Safety of Multi-mode Ablation Combined With Systemic Therapy in the Treatment of CRCLM
NCT06590259 · ClinicalTrials.gov ↗ · Colorectal Cancer Liver Metastasis
|
Phase 2 |
Recruiting |
Shanghai 6th People's Hospital |
China |
Irinotecan Hydrochloride Liposome Injection (โ
ก) Combined with Fluorouracil, Folinic Acid, Vermofenib and Cetuximab in First-line Treatment of BRAFV600E Mutated Advanced Colorectal Cancer
NCT06603376 · ClinicalTrials.gov ↗ · Colorectal Carcinoma
|
Phase 2 |
Recruiting |
Shanghai Changzheng Hospital |
China |
Irinotecan Liposomes Combined with Cetuximab + Vermofenib in First-line Failure of Advanced Colorectal Cancer
NCT06763029 · ClinicalTrials.gov ↗ · Colorectal Cancer Metastatic
|
Phase 2 |
Recruiting |
Fudan University |
China |
Dalpicilib Plus Cetuximab Compared With Cetuximab Alone in HPV-negative, Anti-PD-1-resistant R/M HNSCC
NCT06935188 · ClinicalTrials.gov ↗ · Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
|
Phase 2 |
Recruiting |
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University |
China |
|
Cetuximab + Tislelizumab + Chemotherapy in the Treatment of Unresectable LA HNSCC
|
Phase 2 |
Recruiting |
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University |
China |
Clinical Study of Irinotecan Liposome (II)-Based Combination Treatment for Irinotecan-resistant Colorectal Cancer.
NCT07044921 · ClinicalTrials.gov ↗ · Colorectal Cancer Metastatic
|
Phase 2 |
Recruiting |
Chinese PLA General Hospital |
China |
IBI351 Plus Cetuximab ฮฒ in Untreated Advanced Non-small Cell Lung Cancer With KRAS G12C Mutation
NCT07198841 · ClinicalTrials.gov ↗ · Lung Cancer (Non-Small Cell)
|
Phase 2 |
Recruiting |
Guangdong Association of Clinical Trials |
China |
A Clinical Study of Calderasib (MK-1084) in People With Advanced Solid Tumors (MK-1084-014)
NCT07209111 · ClinicalTrials.gov ↗ · Neoplasm Malignant
|
Phase 2 |
Recruiting |
Merck Sharp & Dohme LLC |
UK, USA, China |
KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)
NCT07252739 · ClinicalTrials.gov ↗ · Malignant Neoplasm
|
Phase 2 |
Recruiting |
Merck Sharp & Dohme LLC |
USA, China |
|
A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies
|
Phase 2 |
Recruiting |
Mirati Therapeutics Inc. |
UK, USA, China |
|
A Phase II Study of AMT-676 Combination Therapies in Advanced Colorectal Cancer
|
Phase 2 |
Recruiting |
Multitude Therapeutics Inc. |
China |
|
A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)
|
Phase 2 |
Recruiting |
Bristol-Myers Squibb |
Ireland, USA, China |
A Phase II Study of Sintilimab Combined With Ipilimumab N01, Cetuximab and Dabrafenib in Patients With Microsatellite-Stable, BRAF V600E-Mutated Metastatic Colorectal Cancer
NCT07506109 · ClinicalTrials.gov ↗ · BRAF V600E, Colorectal Cancer, Sintilimab
|
Phase 2 |
Recruiting |
Tianjin Medical University Cancer Institute and Hospital |
China |
A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Pancreatic Cancer
NCT07644559 · ClinicalTrials.gov ↗ · Pancreatic Ductal Adenocarcinoma (PDAC), G12D Mutated KRAS
|
Phase 2 |
Recruiting |
Verastem, Inc. |
USA |
|
A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Colorectal Cancer
|
Phase 2 |
Recruiting |
Verastem, Inc. |
USA |
Bevacizumab, Sintilimab, Cetuximab and Irinotecan in Refractory RAS Wild-type Metastatic Colorectal Cancer: BOND-4 Trial
NCT07722754 · ClinicalTrials.gov ↗ · Colorectal Neoplasms Malignant, Neoplasm, Metastatic
|
Phase 2 |
Recruiting |
Guangdong Provincial People's Hospital |
China |
|
A Study of D3S-001 Monotherapy or Combination Therapy in Subjects With Advanced Solid Tumors With a KRAS p.G12C Mutation
|
Phase 1/2 |
Recruiting |
D3 Bio (Wuxi) Co., Ltd |
USA, China |
|
A First-in-human, Dose Escalation and Dose Expansion Study of SAR445877 in Adult Participants With Advanced Solid Tumors
|
Phase 1/2 |
Recruiting |
Sanofi |
USA |
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
NCT05786924 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer, Histiocytic Neoplasm, Histiocytosis
|
Phase 1/2 |
Recruiting |
Institut de Recherches Internationales Servier |
China |
Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
NCT06128551 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer, Pancreatic Ductal Adenocarcinoma
|
Phase 1/2 |
Recruiting |
Revolution Medicines, Inc. |
USA |
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
NCT06445062 · Colorectal Cancer, CRC, Pancreatic Ductal Adenocarcinoma
|
Phase 1/2 |
Recruiting |
Revolution Medicines, Inc. |
USA |
A Study of GFH375 in Patients With Advanced Solid Tumors With KRAS G12D Mutations
NCT06500676 · ClinicalTrials.gov ↗ · KRAS G12D Mutations, Advanced Solid Tumors
|
Phase 1/2 |
Recruiting |
Genfleet Therapeutics (Shanghai) Inc. |
China |
Sintilimab in Combination with Cetuximab and Chemotherapy As First-line Treatment for RAS/BRAF Wild-type Advanced Colorectal Cancer
NCT06776757 · ClinicalTrials.gov ↗ · Metastatic Colorectal Cancer
|
Phase 1/2 |
Recruiting |
Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center |
China |
AK129 Combination Therapy for Advanced Solid Tumors
NCT06943820 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer Stage IIIB/IV, Head and Neck Squamous Cell Carcinoma (HNSCC), Colorectal Adenocarcinoma
|
Phase 1/2 |
Recruiting |
Akeso |
China |
ctDNA-Guided Cetuximab or Bevacizumab Plus Trifluridine/Tipiracil in RAS/BRAF Wild-Type mCRC
NCT07012954 · ClinicalTrials.gov ↗ · Colorectal Cancer Metastatic
|
Phase 1/2 |
Recruiting |
Sun Yat-sen University |
China |
A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
NCT07020221 · ClinicalTrials.gov ↗ · Pancreatic Ductal Adenocarcinoma, Non Small Cell Lung Cancer, Colorectal Cancer
|
Phase 1/2 |
Recruiting |
Verastem, Inc. |
USA |
A Trial of SHR-A2102 With Adebrelimab With or Without Other Anti-tumor Therapies in Recurrent/MetastaticHead and Neck Squamous Cell Carcinoma Cancer
NCT07059221 · ClinicalTrials.gov ↗ · Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
|
Phase 1/2 |
Recruiting |
Suzhou Suncadia Biopharmaceuticals Co., Ltd. |
China |
A Study to Evaluate the Safety, Tolerability, and Efficacy of BMS-986523 Alone and in Combination With Anti-Cancer Agents in Participants With Advanced Solid Malignancies
NCT07223047 · ClinicalTrials.gov ↗ · Advanced Solid Malignancies, Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC)
|
Phase 1/2 |
Recruiting |
Bristol-Myers Squibb |
USA |
|
A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F)
|
Phase 1/2 |
Recruiting |
Merck Sharp & Dohme LLC |
USA, China |
Study of RAS(ON) Inhibitors in Combination With Ivonescimab in Patients With Solid Tumors
NCT07397338 · ClinicalTrials.gov ↗ · Advanced Solid Tumors, Metastatic Solid Tumors, Non-small Cell Lung Cancer (NSCLC)
|
Phase 1/2 |
Recruiting |
Revolution Medicines, Inc. |
USA |
Rollover Study for Participants Who Have Been Treated With and Are Continuing to Benefit From Opnurasib as a Single Agent or in Combination With Other Study Treatments
NCT07468071 · ClinicalTrials.gov ↗ · Locally Advanced or Metastatic KRAS G12C-mutated Non-small Cell Lung Cancer, Advanced Solid Tumors Harboring the KRAS G12C Mutation
|
Phase 1/2 |
Recruiting |
Novartis Pharmaceuticals |
China |
HSK42360-Na Tablets Combined With Cetuximab With or Without Chemotherapy in BRAF V600-Mutant Metastatic Colorectal Cancer
NCT07790510 · ClinicalTrials.gov ↗ · Metastatic Colorectal Cancer (CRC)
|
Phase 1/2 |
Recruiting |
Haisco Pharmaceutical Group Co., Ltd. |
China |
A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
NCT04929223 · ClinicalTrials.gov ↗ · Metastatic Colorectal Cancer
|
Phase 1 |
Recruiting |
Hoffmann-La Roche |
UK, USA |
|
A Study of Calderasib (MK-1084) in KRAS Mutant Advanced Solid Tumors (MK-1084-001)
|
Phase 1 |
Recruiting |
Merck Sharp & Dohme LLC |
USA, China |
|
A Study of ASP3082 in Adults With Advanced Solid Tumors
|
Phase 1 |
Recruiting |
Astellas Pharma Inc |
USA, China |
Efficacy and Safety of IBI351 in Combination With Chemotherapy in Advanced Non-squamous Non-small Cell Lung Cancer Subjects With KRAS G12C Mutation
NCT05504278 · ClinicalTrials.gov ↗ · Advanced Non-Small Cell Lung Cancer
|
Phase 1 |
Recruiting |
Innovent Biologics (Suzhou) Co. Ltd. |
China |
A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors
NCT05836324 · Solid Tumors, Advanced Solid Tumors, Metastatic Solid Tumors
|
Phase 1 |
Recruiting |
Incyte Corporation |
UK, USA, China |
|
A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
|
Phase 1 |
Recruiting |
Incyte Corporation |
USA |
FT825/ONO-8250, an Off-the-Shelf, HER2 CAR-T, With or Without Monoclonal Antibodies in Advanced Solid Tumors
NCT06241456 · ClinicalTrials.gov ↗ · Advanced Solid Tumor
|
Phase 1 |
Recruiting |
Fate Therapeutics |
USA |
ARTEMIS-101: A Study of HS-20093 Combinations in Patients With Advanced Solid Tumors
NCT06332170 · ClinicalTrials.gov ↗ · Advanced Solid Tumor
|
Phase 1 |
Recruiting |
Hansoh BioMedical R&D Company |
China |
|
A Study of GSK5764227 in Participants With Advanced Solid Tumors (EMBOLD)
|
Phase 1 |
Recruiting |
GlaxoSmithKline |
UK, USA |
MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors
NCT06586515 · ClinicalTrials.gov ↗ · Pancreatic Ductal Adenocarcinoma, Non-small Cell Lung Cancer, Colorectal Cancer
|
Phase 1 |
Recruiting |
Eli Lilly and Company |
Ireland, USA, China |
A Study to Investigate the Safety and Efficacy of KQB365 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies
NCT06720987 · ClinicalTrials.gov ↗ · KRAS G12C Mutation, KRAS G12S Mutation, Solid Tumor Malignancies
|
Phase 1 |
Recruiting |
Kumquat Biosciences Inc. |
USA |
A Study of BMS-986488 as Monotherapy and Combination Therapy in Participants With Advanced Malignant Tumors
NCT06764771 · ClinicalTrials.gov ↗ · Advanced Malignant Tumors
|
Phase 1 |
Recruiting |
Bristol-Myers Squibb |
USA |
|
A Study of PT0253 in Participants With KRAS G12D Mutated Advanced Solid Tumors
|
Phase 1 |
Recruiting |
PAQ Therapeutics, Inc. |
USA |
A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations
NCT06835569 · ClinicalTrials.gov ↗ · Cancer, PDAC - Pancreatic Ductal Adenocarcinoma, NSCLC (Non-small Cell Lung Cancer)
|
Phase 1 |
Recruiting |
Alterome Therapeutics, Inc. |
USA |
BBO-11818 in Adult Subjects With KRAS Mutant Cancer
NCT06917079 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer, NSCLC, PDAC - Pancreatic Ductal Adenocarcinoma
|
Phase 1 |
Recruiting |
TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics) |
USA |
|
Study of AUBE00 in Patients With Solid Tumors
|
Phase 1 |
Recruiting |
Chugai Pharmaceutical |
USA |
FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors
NCT07216105 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer, Colorectal Cancer, Breast Cancer
|
Phase 1 |
Recruiting |
Fate Therapeutics |
USA |
|
A Clinical Study of MK-4716 in People With Certain Solid Tumors (MK-4716-001)
|
Phase 1 |
Recruiting |
Merck Sharp & Dohme LLC |
USA |
A Study of PT0511 in Participants With KRAS Mutated or Amplified Advanced Solid Tumors
NCT07300150 · Colorectal Cancer, Pancreatic Cancer, Non-Small Cell Lung Cancer
|
Phase 1 |
Recruiting |
PAQ Therapeutics, Inc. |
USA |
A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors
NCT07318805 · ClinicalTrials.gov ↗ · Advanced Breast Cancer, Metastatic Breast Cancer (HR+/ HER2-), Colorectal Cancer
|
Phase 1 |
Recruiting |
Pfizer |
USA |
Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors
NCT07349537 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Adenocarcinoma
|
Phase 1 |
Recruiting |
Revolution Medicines, Inc. |
USA |
A Study to Learn More About How Safe BAY 3771249 is and How Well it Works in People With Advanced or Metastatic Colorectal Cancer That Has a KRAS G12D Mutation
NCT07535112 · Advanced/Metastatic Colorectal Adenocarcinoma
|
Phase 1 |
Recruiting |
Bayer |
USA |
A Randomized, Double-Blind, Positive-Controlled, Parallel Pharmacokinetic Phase I Clinical Study of Cetuximab Injection Versus Erbitux in Healthy Male Subjects
NCT07813468 · ClinicalTrials.gov ↗ · Cetuximab, Bioequivalence, Healthy Volunteers
|
Phase 1 |
Recruiting |
HC Biopharma Inc. |
China |
First-line Treatment of MCapOX + Cetuximab Vs. MFOLFOX6 + Cetuximab for RAS/BRAF Wild-type, MSS, Unresectable Left-Sided MCRC: a Multicenter, Randomized, Controlled, Phase III Study
NCT06616259 · ClinicalTrials.gov ↗ · Colorectal Cancer (CRC), Capecitabine, Cetuximab
|
Phase 3 |
Not yet open |
Meng Qiu |
China |
Cetuximab Combined With Pembrolizumab or Finotonlimab and Chemotherapy in R/M HNSCC
NCT07509099 · ClinicalTrials.gov ↗ · Squamous Cell Carcinoma of Head and Neck
|
Phase 3 |
Not yet open |
Ji Dongmei |
China |
A Study to Evaluate CRB-701 Compared to Investigator's Choice Therapy in Previously Treated Oropharyngeal Squamous Cell Carcinoma
NCT07768189 · ClinicalTrials.gov ↗ · Oropharyngeal Carcinoma (OPC)
|
Phase 3 |
Not yet open |
Corbus Pharmaceuticals Inc. |
UK, USA |
Neoadjuvant PD-1 Inhibitor Combined With Cetuximab in Operable Locally Advanced HNSCC
NCT05993858 · ClinicalTrials.gov ↗ · Head and Neck Squamous Cell Carcinoma, Neoadjuvant Therapy
|
Phase 2 |
Not yet open |
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology |
China |
A Study of Cetuximabฮฒ Combined With Envolimab and mFOLFOX6 in Subjects With Advanced Colorectal Cancer
NCT07000305 · ClinicalTrials.gov ↗ · Advanced Colorectal Cancer
|
Phase 2 |
Not yet open |
Tao Zhang |
China |
Dual EGFR/HER2 Blockade Combined With Irinotecan for the Treatment of HER2-Positive Metastatic Colorectal Cancer
NCT07059338 · ClinicalTrials.gov ↗ · HER2 Positive, Colorectal Cancer (CRC)
|
Phase 2 |
Not yet open |
Sun Yat-sen University |
China |
Efficacy and Safety of FOLFOX+Cetuximab vs. FOLFOXIRI+Bevacizumab Both With QL1706 in First-Line Treatment of Left-Sided mCRC
NCT07070713 · ClinicalTrials.gov ↗ · Metastatic Colorectal Cancer With Left-sided Primary Tumor, Immunotherapy
|
Phase 2 |
Not yet open |
Fujian Cancer Hospital |
China |
Neoadjuvant and Adjuvant Sintilimab Plus Cetuximab in Locally Advanced Oral and Oropharyngeal Squamous Cell Carcinoma
NCT07079410 · ClinicalTrials.gov ↗ · Oral Squamous Cell Carcinoma (OSCC), Oropharyngeal Squamous Cell Carcinoma, Resectable Oral and Oropharyngeal Squamous Cell Carcinoma
|
Phase 2 |
Not yet open |
Shanghai Zhongshan Hospital |
China |
GFH375 Monotherapy and Combination Therapy as First-Line Treatment for Advanced KRAS G12D-Mutant Non-Small Cell Lung Cancer
NCT07554859 · ClinicalTrials.gov ↗ · NSCLC (Advanced Non-small Cell Lung Cancer)
|
Phase 2 |
Not yet open |
Genfleet Therapeutics (Shanghai) Inc. |
China |
|
A Phase II Study of GFH375 Combined With GFS202A or GFH276 Versus GFH375 Monotherapy in Patients With Previously Treated Locally Advanced Unresectable or Metastatic Pancreatic Cancer Harboring KRAS G12D Mutation
|
Phase 2 |
Not yet open |
Genfleet Therapeutics (Shanghai) Inc. |
China |
A Study of GFH276 Combined With Cetuximab or Chemotherapy in Participants With Solid Tumors and Pancreatic Ductal Adenocarcinoma (PDAC) Harboring RAS Mutation
NCT07678593 · ClinicalTrials.gov ↗ · Advanced Solid Tumors Cancer, Pancreatic Ductal Adenocarcinoma, RAS Mutation
|
Phase 1/2 |
Not yet open |
Genfleet Therapeutics (Shanghai) Inc. |
China |
BRIDGE Study: Neoadjuvant Finotonlimab, Cetuximab, and Docetaxel in Resectable Recurrent HNSCC After Immunotherapy Progression
NCT07618624 · ClinicalTrials.gov ↗ · Recurrent Head and Neck Squamous Cell Carcinoma, Head and Neck Cancer
|
Phase 2 |
By invitation |
Sun Yat-sen University |
China |
RT With or Without Cetuximab in Treating Patients Who Have Undergone Surgery for Locally Advanced Head and Neck Cancer
NCT00956007 · ClinicalTrials.gov ↗ · Head and Neck Cancer
|
Phase 3 |
Active, closed |
Radiation Therapy Oncology Group |
Ireland, China |
A Study of Nivolumab, Nivolumab Plus Ipilimumab, or Investigator's Choice Chemotherapy for the Treatment of Participants With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC)
NCT04008030 · ClinicalTrials.gov ↗ · Metastatic Colorectal Cancer
|
Phase 3 |
Active, closed |
Bristol-Myers Squibb |
Ireland, UK, USA, China |
Assessment of Efficacy and Safety of Monalizumab Plus Cetuximab Compared to Placebo Plus Cetuximab in Recurrent or Metastatic Head and Neck Cancer
NCT04590963 · ClinicalTrials.gov ↗ · Squamous Cell Carcinoma of the Head and Neck
|
Phase 3 |
Active, closed |
AstraZeneca |
UK, USA |
|
A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer
|
Phase 3 |
Active, closed |
Pfizer |
UK, USA, India, China |
Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)
NCT04793958 · ClinicalTrials.gov ↗ · Advanced Colorectal Cancer, Metastatic Colorectal Cancer
|
Phase 3 |
Active, closed |
Mirati Therapeutics Inc. |
Ireland, UK, USA, China |
Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Chinese Participants With Stage IV Colorectal Cancer (MK-3475-C66)
NCT05239741 · ClinicalTrials.gov ↗ · Colorectal Neoplasms
|
Phase 3 |
Active, closed |
Merck Sharp & Dohme LLC |
China |
Neoadjuvant Chemotherapy Combined With Cetuximab for EGFR Wild Type Locally Advanced Rectal Cancer
NCT03391843 · ClinicalTrials.gov ↗ · Rectal Cancer Stage III
|
Phase 2 |
Active, closed |
RenJi Hospital |
China |
A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer
NCT05217446 · ClinicalTrials.gov ↗ · Metastatic Colorectal Cancer
|
Phase 2 |
Active, closed |
Pfizer |
UK, USA |
Study for Participants Continuing From Pfizer-sponsored Palbociclib (a Study Medicine) Studies
NCT05226871 · ClinicalTrials.gov ↗ · Breast Cancer, Head and Neck Cancer
|
Phase 2 |
Active, closed |
Pfizer |
USA, China |
AK117 (Anti-CD47 mAb) Plus Cetuximab or AK104 (Anti-PD-1/CTLA-4 bsAb) as Second-Line Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
NCT06508606 · ClinicalTrials.gov ↗ · Head and Neck Squamous Cell Carcinoma
|
Phase 2 |
Active, closed |
West China Hospital |
China |
|
A Study of Durvalumab (MEDI4736) and Monalizumab in Solid Tumors
|
Phase 1/2 |
Active, closed |
MedImmune LLC |
UK, USA |
Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1
NCT03785249 · Advanced Cancer, Metastatic Cancer, Malignant Neoplastic Disease
|
Phase 1/2 |
Active, closed |
Mirati Therapeutics Inc. |
USA |
Study of LY3537982 in Cancer Patients With a Specific Genetic Mutation (KRAS G12C)
NCT04956640 · ClinicalTrials.gov ↗ · Carcinoma, Non-Small-Cell Lung, Colorectal Neoplasms, Endometrial Neoplasms
|
Phase 1/2 |
Active, closed |
Eli Lilly and Company |
USA |
JAB-21822 in Combination With Cetuximab in Patients With Advanced CRC and Other Solid Tumors With KRAS G12C Mutation
NCT05194995 · ClinicalTrials.gov ↗ · Advanced Colorectal Cancer, Small Intestinal Cancer, Appendiceal Cancer
|
Phase 1/2 |
Active, closed |
Allist Pharmaceuticals, Inc. |
China |
Platform Study of JDQ443 in Combinations in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation
NCT05358249 · ClinicalTrials.gov ↗ · KRAS G12C Mutant Solid Tumors, Carcinoma, Non-Small Cell Lung, Carcinoma, Non-Small-Cell Lung
|
Phase 1/2 |
Active, closed |
Novartis Pharmaceuticals |
USA |
A Study of HRS-4642 in Patients With Advanced Solid Tumors Harboring KRAS G12D Mutation
NCT06385678 · ClinicalTrials.gov ↗ · Advanced KRAS G12D Mutant Solid Tumors
|
Phase 1/2 |
Active, closed |
Jiangsu HengRui Medicine Co., Ltd. |
China |
|
Safety and Efficacy of HCB101 in Combination With Multiple Agents in Patients With Advanced Solid Tumors
|
Phase 1/2 |
Active, closed |
FBD Biologics Limited |
China |
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation
NCT04449874 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer, Colorectal Cancer, Advanced Solid Tumors
|
Phase 1 |
Active, closed |
Genentech, Inc. |
UK, USA |
|
TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers
|
Phase 1 |
Active, closed |
Tizona Therapeutics, Inc |
USA |
A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.
NCT05355701 · ClinicalTrials.gov ↗ · Melanoma, Non-Small-Cell Lung Cancer, Thyroid Cancer
|
Phase 1 |
Active, closed |
Pfizer |
USA |
A Study of the Pan-KRAS Inhibitor LY4066434 in Participants With KRAS Mutant Solid Tumors
NCT06607185 · ClinicalTrials.gov ↗ · Pancreatic Ductal Adenocarcinoma, Non-small Cell Lung Cancer, Colorectal Cancer
|
Phase 1 |
Active, closed |
Eli Lilly and Company |
USA |
A Study to Test Whether Treatment With BI 770371 in Combination With Pembrolizumab With or Without Cetuximab Helps People With Head and Neck Cancer Compared With Pembrolizumab Alone
NCT06806852 · ClinicalTrials.gov ↗ · Head and Neck Squamous Cell Carcinoma
|
Phase 1 |
Active, closed |
Boehringer Ingelheim |
UK, USA |
|
A Study to Evaluate INCB186748 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
|
Phase 1 |
Active, closed |
Incyte Corporation |
USA |