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Compound · clinical trials

Herceptin clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 26 trials in our France, Spain, Italy, Germany, South Korea, Taiwan, UK, China, Belgium, Portugal, Canada, Japan, Australia, USA, Brazil, Mexico, Netherlands, Poland, Austria, Israel, Singapore, Switzerland, Czechia, Ireland, India, Turkey, Norway, Denmark and Sweden registers that name Herceptin as an intervention. Synced 26 Sep 2026
26Current trials
8Recruiting now
23Lead sponsors
29Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

Herceptin is named as an intervention in 26 current clinical trials in our France, Spain, Italy, Germany, South Korea, Taiwan, UK, China, Belgium, Portugal, Canada, Japan, Australia, USA, Brazil, Mexico, Netherlands, Poland, Austria, Israel, Singapore, Switzerland, Czechia, Ireland, India, Turkey, Norway, Denmark and Sweden registers. 8 are recruiting patients now. The most common phase is Phase 2. The sponsor with the most trials is Seagen, a wholly owned subsidiary of Pfizer (2). The most-studied condition is Breast Cancer.

Trials by status

  • Recruiting831%
  • Not yet open14%
  • Active, closed1765%

Trials by phase

  • Phase 21038%
  • Phase 3935%
  • Phase 1/228%
  • Phase 128%
  • Phase 2/314%
  • Phase 414%
  • Observational14%
01

Clinical trials of Herceptin

26 trials
StudyPhaseStatusLead sponsorRegisters
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
NCT05253651 · ClinicalTrials.gov ↗ · Colorectal Neoplasms
Phase 3 Recruiting Seagen, a wholly owned subsidiary of Pfizer Ireland, UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Switzerland, Austria, Norway, Portugal, Canada, Brazil, Japan, South Korea, Taiwan, Australia
ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab
NCT06876714 · ClinicalTrials.gov ↗ · Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Early Stage HER2+ Breast Cancer
Phase 3 Recruiting Alliance for Clinical Trials in Oncology Mexico
Neoadjuvant Pyrotinib-to-pertuzumab in HER2+ eBC
NCT07797218 · ClinicalTrials.gov ↗ · Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Phase 3 Recruiting Shanghai Jiao Tong University School of Medicine China
Safety of Continuing HER-2 Directed Therapy in Overt Left Ventricular Dysfunction
NCT04680442 · ClinicalTrials.gov ↗ · Breast Cancer, Heart Failure
Phase 2 Recruiting Population Health Research Institute Canada, Brazil
Trastuzumab Deruxtecan Versus Standard Neoadjuvant Treatment for HER2-positive Breast Cancer
NCT05900206 · ClinicalTrials.gov ↗ · Breast Cancer
Phase 2 Recruiting Karolinska University Hospital Sweden
ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer
NCT07007559 · Breast Cancer, Metastatic
Phase 2 Recruiting ALX Oncology Inc UK, USA, France, Spain, Italy, Canada, South Korea, Singapore
Tucatinib and Trastuzumab in HER3-mutant and HER2-not Amplified Metastatic Breast Cancer
NCT07193394 · ClinicalTrials.gov ↗ · Metastatic Breast Cancer ( HER2 Negative), Unresectable Breast Cancer
Phase 2 Recruiting Institut Curie France
Neoadjuvant Trastuzumab, Pertuzumab and Tucatinib Without Chemotherapy in HER2-positive Breast Cancer: the TRAIN-4 Study
NCT06162559 · ClinicalTrials.gov ↗ · Breast Cancer
Phase 1 Recruiting The Netherlands Cancer Institute Netherlands
Phase II Study of Ultrasound and ctDNA Guided Neoadjuvant Systemic Therapy for Patients With HER2-positive Early Breast Cancer (UC HER Trial)
NCT07565324 · ClinicalTrials.gov ↗ · HER-2 Positive Breast Cancer
Phase 2 Not yet open National Taiwan University Hospital Taiwan
Evaluating 6-months of HER2-targeted Therapy in Patients With HER2 Positive Early-stage Breast Cancer That Achieve a Pathological Complete Response to Neoadjuvant Systemic Therapy
NCT04928261 · ClinicalTrials.gov ↗ · Breast Cancer
Phase 4 Active, closed Ottawa Hospital Research Institute Canada
Randomized, Open Label, Clinical Study of the Targeted Therapy, Palbociclib, to Treat Metastatic Breast Cancer
NCT02947685 · ClinicalTrials.gov ↗ · HER-2 Positive Breast Cancer, Estrogen Receptor Positive Breast Cancer
Phase 3 Active, closed Alliance Foundation Trials, LLC Germany, France, Spain, Italy, Portugal, Mexico, Australia
Neoadjuvant Treatment of HER2 Positive Early High-risk and Locally Advanced Breast Cancer
NCT03595592 · ClinicalTrials.gov ↗ · Invasive Breast Cancer
Phase 3 Active, closed Fondazione Michelangelo Germany, Spain, Italy, Austria
A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy
NCT04873362 · Breast Cancer
Phase 3 Active, closed Hoffmann-La Roche UK, USA, India, China, Germany, France, Spain, Italy, Belgium, Denmark, Poland, Austria, Czechia, Portugal, Turkey, Brazil, Mexico, South Korea, Taiwan, Singapore, Australia
Trastuzumab + Alpelisib +/- Fulvestrant vs Trastuzumab + CT in Patients With PIK3CA Mutated Previously Treated HER2+ Advanced BrEasT Cancer (ALPHABET)
NCT05063786 · ClinicalTrials.gov ↗ · Advanced Breast Cancer
Phase 3 Active, closed Spanish Breast Cancer Research Group France, Spain, Italy, Netherlands, Switzerland, Austria
A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer
NCT05132582 · ClinicalTrials.gov ↗ · HER2 Positive Breast Cancer
Phase 3 Active, closed Seagen, a wholly owned subsidiary of Pfizer UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Switzerland, Austria, Czechia, Portugal, Canada, Brazil, Japan, South Korea, Taiwan, Australia, Israel
A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers
NCT05152147 · ClinicalTrials.gov ↗ · Gastric Neoplasms, Gastroesophageal Adenocarcinoma, Esophageal Adenocarcinoma
Phase 3 Active, closed Jazz Pharmaceuticals Ireland, UK, India, China, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Portugal, Turkey, Canada, Brazil, Mexico, Japan, South Korea, Taiwan, Singapore, Australia
A Study of Evorpacept (ALX148) in Patients With Advanced HER2+ Gastric Cancer (ASPEN-06)
NCT05002127 · Gastric Cancer, Gastroesophageal Junction Adenocarcinoma, Gastric Adenocarcinoma
Phase 2/3 Active, closed ALX Oncology Inc UK, USA, China, France, Spain, Italy, Belgium, Czechia, Japan, South Korea, Taiwan, Singapore, Australia
A Safety Extension Study of Trastuzumab Emtansine in Participants Previously Treated With Trastuzumab Emtansine Alone or in Combination With Other Anti-Cancer Therapy in One of the Parent Studies
NCT00781612 · ClinicalTrials.gov ↗ · Neoplasm Metastasis
Phase 2 Active, closed Genentech, Inc UK, USA, China, Germany, France, Spain, Italy, Belgium, Denmark, Poland, Switzerland, Czechia, Norway, Portugal, Canada, Brazil, Mexico, Japan, South Korea, Taiwan, Australia, Israel
Chemotherapy-free Trastuzumab and Pertuzumab in HER2-positive Breast Cancer: FDG-PET Response-adapted Strategy.
NCT03161353 · ClinicalTrials.gov ↗ · Breast Cancer
Phase 2 Active, closed MedSIR Germany, France, Spain, Italy, Belgium, Portugal
Neoadjuvant Her2-targeted Therapy and Immunotherapy With Pembrolizumab [IIT2018-04-MCARTHUR-NEOHP]
NCT03747120 · ClinicalTrials.gov ↗ · HER2-positive Breast Cancer, Breast Cancer
Phase 2 Active, closed University of Texas Southwestern Medical Center Mexico
MARGetuximab Or Trastuzumab (MARGOT)
NCT04425018 · ClinicalTrials.gov ↗ · Breast Cancer, Stage II Breast Cancer, Stage III Breast Cancer
Phase 2 Active, closed Dana-Farber Cancer Institute Israel
A Study of Tucatinib (MK-7119) in Combination With Trastuzumab and Capecitabine in Participants With Previously Treated Locally Advanced Unresectable or Metastatic Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Breast Carcinoma (MK-7119-001)
NCT04721977 · ClinicalTrials.gov ↗ · Breast Cancer
Phase 2 Active, closed Pfizer Japan, South Korea, Taiwan
Anastrozole, Palbociclib, Trastuzumab and Pertuzumab in HR-positive, HER2-positive Metastatic Breast
NCT03304080 · ClinicalTrials.gov ↗ · Breast Neoplasms, Breast Diseases
Phase 1/2 Active, closed Icahn School of Medicine at Mount Sinai Israel
Trial of Ibrutinib Plus Trastuzumab in HER2-amplified Metastatic Breast Cancer
NCT03379428 · ClinicalTrials.gov ↗ · Breast Neoplasms, Malignant Neoplasm of Breast
Phase 1/2 Active, closed US Oncology Research USA
DAPHNe: Paclitaxel/Trastuzumab/Pertuzumab in HER2-Positive BC
NCT03716180 · ClinicalTrials.gov ↗ · Breast Cancer
Phase 1 Active, closed Dana-Farber Cancer Institute Israel
Personalized Detection of ctDNA for Patients With HER2-Positive Metastatic Breast Cancer Patients Who Achieved Durable Response to Anti-HER2 Treatment
NCT06663787 · ClinicalTrials.gov ↗ · Breast Cancer, Metastatic, HER2 + Breast Cancer
Observational Active, closed Nagoya City University Japan

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Herceptin

29 conditions
All 29 conditions
Condition (as registered)Trials
Breast Cancer10
Breast Cancer, Metastatic2
Breast Neoplasms2
HER-2 Positive Breast Cancer2
HER2-positive Breast Cancer2
Gastric Neoplasms1
Gastroesophageal Adenocarcinoma1
Esophageal Adenocarcinoma1
Colorectal Neoplasms1
Gastric Cancer1
Gastroesophageal Junction Adenocarcinoma1
Gastric Adenocarcinoma1
HER2 Positive Breast Cancer1
Neoplasm Metastasis1
Malignant Neoplasm of Breast1
Breast Cancer Early Stage Breast Cancer (Stage 1-3)1
Invasive Breast Cancer1
Estrogen Receptor Positive Breast Cancer1
Metastatic Breast Cancer ( HER2 Negative)1
Unresectable Breast Cancer1
Advanced Breast Cancer1
Heart Failure1
Anatomic Stage I Breast Cancer AJCC v81
Anatomic Stage II Breast Cancer AJCC v81
Early Stage HER2+ Breast Cancer1
HER2 + Breast Cancer1
Breast Diseases1
Stage II Breast Cancer1
Stage III Breast Cancer1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Seagen, a wholly owned subsidiary of Pfizer2
ALX Oncology Inc2
Dana-Farber Cancer Institute2
Jazz Pharmaceuticals1
Hoffmann-La Roche1
Genentech, Inc1
US Oncology Research1
Shanghai Jiao Tong University School of Medicine1
MedSIR1
Fondazione Michelangelo1
Alliance Foundation Trials, LLC1
Institut Curie1
Spanish Breast Cancer Research Group1
The Netherlands Cancer Institute1
Karolinska University Hospital1

+ 8 more sponsors in the trial list above.

04

By country register

RegisterTrialsRecruiting
Clinical trials in France113
Clinical trials in Spain112
Clinical trials in Italy112
Clinical trials in Germany81
Clinical trials in South Korea82
Clinical trials in Taiwan81
Clinical trials in UK72
Clinical trials in China72
Clinical trials in Belgium71
Clinical trials in Portugal71
Clinical trials in Canada73
Clinical trials in Japan71
Clinical trials in Australia71
Clinical trials in USA72
Clinical trials in Brazil62
Clinical trials in Mexico61
Clinical trials in Netherlands52
Clinical trials in Poland51
Clinical trials in Austria51
Clinical trials in Israel50
Clinical trials in Singapore41
Clinical trials in Switzerland41
Clinical trials in Czechia40
Clinical trials in Ireland21
Clinical trials in India20
Clinical trials in Turkey20
Clinical trials in Norway21
Clinical trials in Denmark20
Clinical trials in Sweden11

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about Herceptin trials

How many clinical trials are testing Herceptin?

26 current trials in our France, Spain, Italy, Germany, South Korea, Taiwan, UK, China, Belgium, Portugal, Canada, Japan, Australia, USA, Brazil, Mexico, Netherlands, Poland, Austria, Israel, Singapore, Switzerland, Czechia, Ireland, India, Turkey, Norway, Denmark and Sweden registers name Herceptin as a drug or biological intervention, as of the registry sync on 26 September 2026. Completed and withdrawn studies are not counted.

Are Herceptin trials recruiting patients?

Yes. 8 of the 26 trials are recruiting: 3 with sites in France, 2 with sites in Spain, 2 with sites in Italy, 1 with sites in Germany, 2 with sites in South Korea, 1 with sites in Taiwan, 2 with sites in UK, 2 with sites in China, 1 with sites in Belgium, 1 with sites in Portugal, 3 with sites in Canada, 1 with sites in Japan, 1 with sites in Australia, 2 with sites in USA, 2 with sites in Brazil, 1 with sites in Mexico, 2 with sites in Netherlands, 1 with sites in Poland, 1 with sites in Austria, 1 with sites in Singapore, 1 with sites in Switzerland, 1 with sites in Ireland, 1 with sites in Norway and 1 with sites in Sweden. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Herceptin clinical trials?

Seagen, a wholly owned subsidiary of Pfizer (2), ALX Oncology Inc (2), Dana-Farber Cancer Institute (2) and Jazz Pharmaceuticals (1), among 23 lead sponsors in total. The number in brackets is how many trials each organisation leads.

Are there Herceptin clinical trials in Ireland?

Yes. 2 trials in our Ireland register (ClinicalTrials.gov). Some may be the same study registered in both. See the Irish clinical trials register for sites and contacts.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Herceptin works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Herceptin works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Herceptin (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 26 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.