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Compound · clinical trials

Perjeta clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 15 trials in our Germany, France, Spain, Italy, Portugal, Brazil, Israel, Mexico, China, Belgium, Poland, Canada, Japan, South Korea, Australia, UK, USA, Netherlands, Switzerland, Austria, Czechia, Taiwan, Denmark, Norway and Sweden registers that name Perjeta as an intervention. Synced 26 Sep 2026
15Current trials
4Recruiting now
14Lead sponsors
25Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

Perjeta is named as an intervention in 15 current clinical trials in our Germany, France, Spain, Italy, Portugal, Brazil, Israel, Mexico, China, Belgium, Poland, Canada, Japan, South Korea, Australia, UK, USA, Netherlands, Switzerland, Austria, Czechia, Taiwan, Denmark, Norway and Sweden registers. 4 are recruiting patients now. The most common phase is Phase 2. The sponsor with the most trials is Dana-Farber Cancer Institute (2). The most-studied condition is Breast Cancer.

Trials by status

  • Recruiting427%
  • Active, closed1173%

Trials by phase

  • Phase 2853%
  • Phase 3427%
  • Phase 1213%
  • Phase 1/217%
01

Clinical trials of Perjeta

15 trials
StudyPhaseStatusLead sponsorRegisters
Safety of Continuing HER-2 Directed Therapy in Overt Left Ventricular Dysfunction
NCT04680442 · ClinicalTrials.gov ↗ · Breast Cancer, Heart Failure
Phase 2 Recruiting Population Health Research Institute Canada, Brazil
Circulating Tumor Cells and Treatment De-escalation After Neoadjuvant Therapy for HER2 Positive Breast Cancer
NCT04993014 · ClinicalTrials.gov ↗ · Breast Neoplasms, HER2-positive Breast Cancer, Circulating Tumor Cell
Phase 2 Recruiting AC Camargo Cancer Center Brazil
Trastuzumab Deruxtecan Versus Standard Neoadjuvant Treatment for HER2-positive Breast Cancer
NCT05900206 · ClinicalTrials.gov ↗ · Breast Cancer
Phase 2 Recruiting Karolinska University Hospital Sweden
Neoadjuvant Trastuzumab, Pertuzumab and Tucatinib Without Chemotherapy in HER2-positive Breast Cancer: the TRAIN-4 Study
NCT06162559 · ClinicalTrials.gov ↗ · Breast Cancer
Phase 1 Recruiting The Netherlands Cancer Institute Netherlands
A Safety and Efficacy Extension Study of Pertuzumab in Patients With Solid Tumors Previously Enrolled in a Hoffmann-La Roche-Sponsored Pertuzumab Clinical Trial
NCT02320435 · ClinicalTrials.gov ↗ · Solid Tumors
Phase 3 Active, closed Hoffmann-La Roche China, Germany, France, Spain, Italy, Poland, Portugal, Brazil, Mexico, Japan, South Korea
Randomized, Open Label, Clinical Study of the Targeted Therapy, Palbociclib, to Treat Metastatic Breast Cancer
NCT02947685 · ClinicalTrials.gov ↗ · HER-2 Positive Breast Cancer, Estrogen Receptor Positive Breast Cancer
Phase 3 Active, closed Alliance Foundation Trials, LLC Germany, France, Spain, Italy, Portugal, Mexico, Australia
Neoadjuvant Treatment of HER2 Positive Early High-risk and Locally Advanced Breast Cancer
NCT03595592 · ClinicalTrials.gov ↗ · Invasive Breast Cancer
Phase 3 Active, closed Fondazione Michelangelo Germany, Spain, Italy, Austria
A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer
NCT05132582 · ClinicalTrials.gov ↗ · HER2 Positive Breast Cancer
Phase 3 Active, closed Seagen, a wholly owned subsidiary of Pfizer UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Switzerland, Austria, Czechia, Portugal, Canada, Brazil, Japan, South Korea, Taiwan, Australia, Israel
A Safety Extension Study of Trastuzumab Emtansine in Participants Previously Treated With Trastuzumab Emtansine Alone or in Combination With Other Anti-Cancer Therapy in One of the Parent Studies
NCT00781612 · ClinicalTrials.gov ↗ · Neoplasm Metastasis
Phase 2 Active, closed Genentech, Inc UK, USA, China, Germany, France, Spain, Italy, Belgium, Denmark, Poland, Switzerland, Czechia, Norway, Portugal, Canada, Brazil, Mexico, Japan, South Korea, Taiwan, Australia, Israel
Chemotherapy-free Trastuzumab and Pertuzumab in HER2-positive Breast Cancer: FDG-PET Response-adapted Strategy.
NCT03161353 · ClinicalTrials.gov ↗ · Breast Cancer
Phase 2 Active, closed MedSIR Germany, France, Spain, Italy, Belgium, Portugal
Neoadjuvant Her2-targeted Therapy and Immunotherapy With Pembrolizumab [IIT2018-04-MCARTHUR-NEOHP]
NCT03747120 · ClinicalTrials.gov ↗ · HER2-positive Breast Cancer, Breast Cancer
Phase 2 Active, closed University of Texas Southwestern Medical Center Mexico
MARGetuximab Or Trastuzumab (MARGOT)
NCT04425018 · ClinicalTrials.gov ↗ · Breast Cancer, Stage II Breast Cancer, Stage III Breast Cancer
Phase 2 Active, closed Dana-Farber Cancer Institute Israel
Treatment With Tucatinib in Patients With an Isolated Brain Progression of a Metastatic Breast Cancer
NCT05041842 · ClinicalTrials.gov ↗ · Metastatic Breast Cancer With a Isolated Brain Progression
Phase 2 Active, closed UNICANCER France
Anastrozole, Palbociclib, Trastuzumab and Pertuzumab in HR-positive, HER2-positive Metastatic Breast
NCT03304080 · ClinicalTrials.gov ↗ · Breast Neoplasms, Breast Diseases
Phase 1/2 Active, closed Icahn School of Medicine at Mount Sinai Israel
DAPHNe: Paclitaxel/Trastuzumab/Pertuzumab in HER2-Positive BC
NCT03716180 · ClinicalTrials.gov ↗ · Breast Cancer
Phase 1 Active, closed Dana-Farber Cancer Institute Israel

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Perjeta

15 conditions
Breast Cancer7HER2-positive Breast Cancer3Breast Neoplasms2HER2 Positive Breast Cancer1Neoplasm Metastasis1Solid Tumors1Invasive Breast Cancer1HER-2 Positive Breast Cancer1Estrogen Receptor Positive Breast Cancer1Metastatic Breast Cancer With a Isolated Brain Progression1Heart Failure1Circulating Tumor Cell1
All 15 conditions
Condition (as registered)Trials
Breast Cancer7
HER2-positive Breast Cancer3
Breast Neoplasms2
HER2 Positive Breast Cancer1
Neoplasm Metastasis1
Solid Tumors1
Invasive Breast Cancer1
HER-2 Positive Breast Cancer1
Estrogen Receptor Positive Breast Cancer1
Metastatic Breast Cancer With a Isolated Brain Progression1
Heart Failure1
Circulating Tumor Cell1
Breast Diseases1
Stage II Breast Cancer1
Stage III Breast Cancer1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Dana-Farber Cancer Institute2
Seagen, a wholly owned subsidiary of Pfizer1
Genentech, Inc1
Hoffmann-La Roche1
MedSIR1
Fondazione Michelangelo1
Alliance Foundation Trials, LLC1
UNICANCER1
The Netherlands Cancer Institute1
Karolinska University Hospital1
Population Health Research Institute1
AC Camargo Cancer Center1
University of Texas Southwestern Medical Center1
Icahn School of Medicine at Mount Sinai1
04

By country register

RegisterTrialsRecruiting
Clinical trials in Germany60
Clinical trials in France60
Clinical trials in Spain60
Clinical trials in Italy60
Clinical trials in Portugal50
Clinical trials in Brazil52
Clinical trials in Israel50
Clinical trials in Mexico40
Clinical trials in China30
Clinical trials in Belgium30
Clinical trials in Poland30
Clinical trials in Canada31
Clinical trials in Japan30
Clinical trials in South Korea30
Clinical trials in Australia30
Clinical trials in UK20
Clinical trials in USA20
Clinical trials in Netherlands21
Clinical trials in Switzerland20
Clinical trials in Austria20
Clinical trials in Czechia20
Clinical trials in Taiwan20
Clinical trials in Denmark10
Clinical trials in Norway10
Clinical trials in Sweden11

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about Perjeta trials

How many clinical trials are testing Perjeta?

15 current trials in our Germany, France, Spain, Italy, Portugal, Brazil, Israel, Mexico, China, Belgium, Poland, Canada, Japan, South Korea, Australia, UK, USA, Netherlands, Switzerland, Austria, Czechia, Taiwan, Denmark, Norway and Sweden registers name Perjeta as a drug or biological intervention, as of the registry sync on 26 September 2026. Completed and withdrawn studies are not counted.

Are Perjeta trials recruiting patients?

Yes. 4 of the 15 trials are recruiting: 2 with sites in Brazil, 1 with sites in Canada, 1 with sites in Netherlands and 1 with sites in Sweden. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Perjeta clinical trials?

Dana-Farber Cancer Institute (2), Seagen, a wholly owned subsidiary of Pfizer (1), Genentech, Inc (1) and Hoffmann-La Roche (1), among 14 lead sponsors in total. The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Perjeta works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Perjeta works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Perjeta (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 26 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.