EXtubation Related Complications - the EXTUBE Study (EXTUBE)

NCT06442930 · tracked via the Priya Life Science Ireland tracker

Sponsor

University Health Network, Toronto

Phase

Observational

Started

2025-04-14

Last updated

2026-10-22

Condition(s) studied

Extubation

Study summary

EXTUBE is an international, multicentre, prospective cohort study evaluating the incidence, risk factors, and outcomes of extubation-related complications and describing clinical practices related to extubation after general anesthesia or after critical illness in the operating room (OR), out of OR anesthesia location or intensive care unit (ICU).

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Adult patients (≥18 years old) * Undergoing extubation of an endotracheal tube (including index extubation and re-extubations) after general anesthesia in the OR, out of OR anesthesia location or ICU * Undergoing extubation during the specified enrollment window Exclusion Criteria: * Patients will be excluded if the extubation is performed in the context of withdrawal of life support measures, * Patients will be excluded if the extubation is performed for tracheostomy decannulation For each patient who is not included, reasons for exclusion will be reported.

Primary outcome measure(s)

At least one of the following, occurring within 60minutes after extubation (composite outcome): i) Severe hypoxemia ii) Cardiac arrest iii) Need for airway management — Within 60 minutes after the end of extubation
The primary outcome will be the occurrence of at least one of the following (composite outcome) occurring within 60 minutes after the end of extubation: i) Severe hypoxemia (oxygen saturation as measured by pulse oximetry falls below SpO2 \< 80% for \> 5 minutes) ii) Cardiac arrest iii) Need for airway management (reintubation, insertion of a supraglottic airway, bag-mask ventilation).

Trial sites (35)

Facility	City	Region	Status
Banner University Medical Centre	Tucson	Arizona	Completed
University of Arkansas for Medical Sciences	Little Rock	Arkansas	Completed
University of Florida	Gainesville	Florida	Completed
The University of Chicago	Chicago	Illinois	Completed
Oregon Health & Science University	Portland	Oregon	Completed
The University of Texas Health Science Center	Houston	Texas	Completed
Royal North Shore Hospital	Sydney	New South Wales	Completed
The Northern Hospital	Melbourne	Victoria	Completed
Austin Health - Heidelberg Repatriation Hospital	Melbourne	Victoria	Completed
Austin Health - Austin Hospital	Melbourne	Victoria	Completed
Eastern Health - Box Hill Hospital	Melbourne	Victoria	Completed
Eastern Health - Maroondah Hospital	Melbourne	Victoria	Completed
Eastern Health - Angliss Hospital	Melbourne	Victoria	Completed
Surrey Memorial Hospital	Surrey	British Columbia	Completed
The Moncton Hospital	Moncton	New Brunswick	Completed
Sunnybrook Hospital	North York	Ontario	Completed
Niagara Health - Marotta Family Hospital	Saint Catharines	Ontario	Completed
St. Michael's Hospital	Toronto	Ontario	Completed
Mount Sinai Hospital	Toronto	Ontario	Completed
University Health Network - Toronto General Hospital	Toronto	Ontario	Recruiting
University Health Network - Toronto Western Hospital	Toronto	Ontario	Completed
Centre hospitalier de l'Université de Montréal (CHUM)	Montreal	Quebec	Completed
Hospital Internacional de Colombia	Piedecuesta	Colombia	Completed
Mayo University Hospital	Castlebar	Ireland	Completed
Cork University Hospital	Cork	Ireland	Completed
Mater Misericordiae University Hospital	Dublin	Ireland	Completed
Galway University Hospitals	Galway	Ireland	Completed
University Hospital Waterford	Waterford	Ireland	Not Yet Recruiting
Amiri Hospital	Kuwait City	Kuwait	Completed
Auckland City Hospital	Auckland	New Zealand	Completed
Southland Hospital	Invercargill	New Zealand	Completed
Rotorua Hospital	Rotorua	New Zealand	Completed
Tan Tock Seng Hospital	Singapore	Singapore	Completed
Royal United Hospitals Bath	Bath	United Kingdom	Completed
Freeman Hospital	Newcastle upon Tyne	United Kingdom	Completed

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06442930 on ClinicalTrials.gov ↗ ← All trials in Ireland