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Compound · clinical trials

Pembrolizumab/Quavonlimab

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 5 trials in our UK, USA, China and Ireland registers that name Pembrolizumab/Quavonlimab as an intervention. Synced 24 Sep 2026
5Trials tracked
0Recruiting now
1Lead sponsor
4Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards

Pembrolizumab/Quavonlimab is named as a drug or biological intervention in 5 clinical trials in our UK, USA, China and Ireland trial registers, none of which are currently recruiting. The lead sponsor is Merck Sharp & Dohme LLC. Registered phases: Phase 3, Phase 1/2 and Phase 2. Conditions studied include Carcinoma, Renal Cell; Colorectal Cancer.

01

Clinical trials of Pembrolizumab/Quavonlimab

5 trials
NCT IDStudyPhaseStatusLead sponsorRegister
NCT04736706 A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)
Carcinoma, Renal Cell
Phase 3 Active, closed Merck Sharp & Dohme LLC Ireland, UK, USA, China
NCT05899049 A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, vs Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)-China Extension Study (ClinicalTrials.gov ↗)
Carcinoma, Renal Cell
Phase 3 Active, closed Merck Sharp & Dohme LLC China
NCT04895722 Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008). (ClinicalTrials.gov ↗)
Colorectal Cancer
Phase 2 Active, closed Merck Sharp & Dohme LLC UK, USA
NCT04626479 Substudy 03A: A Study of Immune and Targeted Combination Therapies in Participants With First Line (1L) Renal Cell Carcinoma (MK-3475-03A)
Carcinoma, Renal Cell
Phase 1/2 Active, closed Merck Sharp & Dohme LLC UK, USA
NCT04626518 Substudy 03B: A Study of Immune and Targeted Combination Therapies in Participants With Second Line Plus (2L+) Renal Cell Carcinoma (MK-3475-03B/KEYMAKER-U03)
Carcinoma, Renal Cell
Phase 1/2 Active, closed Merck Sharp & Dohme LLC UK, USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied

2 conditions
Condition (as registered)Trials
Carcinoma, Renal Cell4
Colorectal Cancer1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Merck Sharp & Dohme LLC5
04

Trials by country register

A trial with sites in more than one country appears in each of those registers.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Pembrolizumab/Quavonlimab works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Pembrolizumab/Quavonlimab (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 24 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.