Metoclopramide clinical trials
Metoclopramide is named as an intervention in 7 current clinical trials in our Ireland, UK, USA, Germany, France, Spain, China, Turkey, Australia, Israel and Egypt registers. 4 are recruiting patients now. The most common phase is Phase 4. The sponsor with the most trials is Mater Misericordiae University Hospital (1). The most-studied condition is Pulmonary Aspiration During Anaesthetic Induction.
Where Metoclopramide is approved
All regulators →Of the three regulators tracked here, the first to approve Metoclopramide was the US, on 7 Feb 1979. It is approved in 2 of the 3 regulators tracked here.
From the regulators' own registers: FDA Drugs@FDA, the EMA medicines list and Health Canada's Notice of Compliance database. Dates are the first listed approval of a product containing only this substance; combination products and nationally authorised EU medicines are not counted.
Metoclopramide patents and exclusivity
Expiry tracker →Protections still running for marketed products containing Metoclopramide, as listed by the regulators. Expired patents and exclusivities, and discontinued products, are not shown.
- 7 listed patents; the last listed expires 17 Nov 2038 (US 12377064).
Reproduced from the FDA Orange Book and Purple Book (checked 8 Nov 2026) and the European Commission's Union Register of medicinal products (CC BY 4.0; the EU expiry date is calculated exactly as the Commission's register displays it). Listed patents and dates are as submitted to or published by the regulator and may not reflect litigation, invalidation, settlements, lapsed fees or later extensions. This is not legal advice or a freedom-to-operate opinion, and it does not say when a generic or biosimilar will launch.
What health systems spend on Metoclopramide
All medicines →From NHSBSA Prescription Cost Analysis (Open Government Licence v3.0) and CMS State Drug Utilization Data. Both are gross amounts: neither system publishes its discounts or rebates per drug. Products combining several substances are not counted here.
How Metoclopramide works
All drug targets →- Dopamine D2 receptor antagonist AntagonistTarget: DRD2 dopamine receptor D2✓ In ChEMBL and the Guide to Pharmacology
- Serotonin 3a (5-HT3a) receptor antagonist AntagonistTarget: HTR3A 5-hydroxytryptamine receptor 3A✓ In ChEMBL and the Guide to Pharmacology
- Serotonin 4 (5-HT4) receptor agonist AgonistTarget: HTR4 5-hydroxytryptamine receptor 4✓ In ChEMBL and the Guide to Pharmacology
- HeadachePhase 3
- VertigoPhase 3
- VomitingPhase 3
- GastroenteritisPhase 3
- Gastroesophageal reflux diseasePhase 3
- GastroparesisPhase 3
- GastroschisisPhase 3
- Gestational diabetesPhase 3
- Migraine disorderPhase 3
- Post operative nausea and vomitingPhase 3
Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL86, CC BY-SA 3.0. Targets checked against the IUPHAR/BPS Guide to PHARMACOLOGY (2026.3.1), ligand 241, CC BY-SA 4.0. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.
Patient leaflets for Metoclopramide
The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.
- IEIreland: 5 products on the HPRA listEach product record links to the HPRA, which publishes the leaflet and SmPC.
- UKUnited Kingdom: Search MHRA ProductsPatient information leaflets and SmPCs for UK-licensed products.
- USUnited States: Search DailyMedFDA-approved labels, including patient and medication guides.
Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.
Reference identifiers for Metoclopramide
- ATC code
- A03FA01
- ChEMBL
- CHEMBL86
- DrugBank
- DB01233
- PubChem CID
- 4168
- CAS number
- 364-62-5
- FDA UNII
- L4YEB44I46
- Wikidata
- Q421095
- Wikipedia
- Metoclopramide
Codes that identify this medicine in other databases, from Wikidata (CC0), matched by its ChEMBL ID. The ATC code is the WHO classification of what the medicine is used for.
Trials by status
Trials by phase
Clinical trials of Metoclopramide
7 trialsRegisters list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.
Metoclopramide across our data
Ireland · EU · USThe same active substance in our other registers, matched by its exact name. Each entry links to the register record it comes from.
Licensed in Ireland (HPRA)
5 single-substance products containing Metoclopramide on the HPRA medicines list.
- Maxolon 10 mg TabletsAmdipharm Limited · PA1142/011/003 · Marketed
- Metoclopramide 5mg/ml Solution for InjectionMercury Pharmaceuticals (Ireland) Ltd · PA0073/084/001 · Marketed
- Maxolon 5 mg/ml Solution for InjectionAmdipharm Limited · PA1142/011/001 · Not marketed
- Metoclopramide hydrochloride 10 mg tabletsAccord Healthcare Ireland Ltd. · PA2315/204/001 · Not marketed
- Metoclopramide hydrochloride 5 mg/ml solution for injectionNoridem Enterprises Limited · PA1122/042/001 · Not marketed
Supply shortages
No entry for Metoclopramide in the EMA, FDA or German BfArM shortage lists we track.
Conditions studied with Metoclopramide
14 conditionsAll 14 conditions
| Condition (as registered) | Trials |
|---|---|
| Pulmonary Aspiration During Anaesthetic Induction | 1 |
| Gastric Emptying Time | 1 |
| Preoperative Risk Assessment | 1 |
| Obesity (Disorder) | 1 |
| Metastatic Neuroendocrine Prostate Cancer | 1 |
| Nausea | 1 |
| Vomiting | 1 |
| Intraoperative Nausea-retching-vomiting Episodes | 1 |
| Spinal Aneshtesia | 1 |
| Ceserean Section | 1 |
| Antiemetic Therapy | 1 |
| Vaccine Response Impaired | 1 |
| Poor Responders in IVF | 1 |
| Enteral Feeding Intolerance | 1 |
Sponsors
lead sponsor per trial| Lead sponsor | Trials |
|---|---|
| Mater Misericordiae University Hospital | 1 |
| Novartis Pharmaceuticals | 1 |
| Affiliated Hospital of Qinghai University | 1 |
| Sanliurfa Education and Research Hospital | 1 |
| South Australian Health and Medical Research Institute | 1 |
| Barzilai Medical Center | 1 |
| Ain Shams University | 1 |
By country register
A trial with sites in more than one country appears in each of those registers.
Related compounds
Questions about Metoclopramide trials
How many clinical trials are testing Metoclopramide?
7 current trials in our Ireland, UK, USA, Germany, France, Spain, China, Turkey, Australia, Israel and Egypt registers name Metoclopramide as a drug or biological intervention, as of the registry sync on 10 November 2026. Completed and withdrawn studies are not counted.
Are Metoclopramide trials recruiting patients?
Yes. 4 of the 7 trials are recruiting: 1 with sites in China, 1 with sites in Turkey, 1 with sites in Australia and 1 with sites in Israel. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.
Who sponsors Metoclopramide clinical trials?
Mater Misericordiae University Hospital (1), Novartis Pharmaceuticals (1), Affiliated Hospital of Qinghai University (1) and Sanliurfa Education and Research Hospital (1), among 7 lead sponsors in total. The number in brackets is how many trials each organisation leads.
Are there Metoclopramide clinical trials in Ireland?
Yes. 1 trial in our Ireland register (ClinicalTrials.gov). Some may be the same study registered in both. See the Irish clinical trials register for sites and contacts.
Is Metoclopramide licensed in Ireland?
Yes. The HPRA medicines list includes 5 single-substance products containing Metoclopramide, for example Maxolon 10 mg Tablets (Amdipharm Limited). A licence does not mean a product is currently marketed or reimbursed; see each product's record.
Is there a Metoclopramide shortage?
Not in the lists we track: Metoclopramide has no entry in the EMA, FDA or German BfArM shortage registers as of their latest sync.
Where does this information come from?
Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Metoclopramide works or whether it is effective, and it is not medical advice.
How this page is built
Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Metoclopramide works or whether it is effective. Each trial links to its own record so you can check it yourself.
- ClinicalTrials.gov (U.S. National Library of Medicine) ↗ Trial IDs, titles, intervention names and synonyms, phase, overall status, lead sponsor and conditions for every trial on this page
This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Metoclopramide (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 10 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.