๐Ÿ‡ฎ๐Ÿ‡ชIreland
16ยฐC Partly Cloudy ยท Dublin
Live Updates
--:--:-- IST
Writer Login
Latest
Priya Life Science Compound trial record
Trackers Drugs Trial finder
Compound · clinical trials

Avelumab clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 13 trials in our USA, UK, China and Ireland registers that name Avelumab as an intervention. Synced 25 Sep 2026
13Current trials
2Recruiting now
12Lead sponsors
4Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

Avelumab is named as an intervention in 13 current clinical trials in our USA, UK, China and Ireland registers. 2 are recruiting patients now. The most common phase is Phase 2. The sponsor with the most trials is EMD Serono Research & Development Institute, Inc (2). The most-studied condition is Metastatic Urothelial Cancer.

Trials by status

  • Recruiting215%
  • Active, closed1185%

Trials by phase

  • Phase 2646%
  • Phase 1323%
  • Phase 3215%
  • Phase 1/2215%
01

Clinical trials of Avelumab

13 trials
StudyPhaseStatusLead sponsorRegisters
Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial
NCT05327686 · ClinicalTrials.gov ↗ · Metastatic Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8
Phase 2 Recruiting NRG Oncology Ireland
Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rฮฑ Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer
NCT05267626 · ClinicalTrials.gov ↗ · Advanced Solid Tumor, Metastatic Cancer, Cutaneous Melanoma
Phase 1/2 Recruiting Aulos Bioscience, Inc. USA
Avelumab Program Rollover Study
NCT03815643 · ClinicalTrials.gov ↗ · Solid Tumors
Phase 3 Active, closed EMD Serono Research & Development Institute, Inc. UK, USA
Continued Access Study for Participants Deriving Benefit in Pfizer-Sponsored Avelumab Parent Studies That Are Closing
NCT05059522 · ClinicalTrials.gov ↗ · Advanced Malignancies, NSCLC, Ovarian Cancer
Phase 3 Active, closed Pfizer UK, USA
QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors
NCT03228667 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Urothelial Carcinoma
Phase 2 Active, closed ImmunityBio, Inc. USA
Study of Sacituzumab Govitecan in Participants With Urothelial Cancer That Cannot Be Removed or Has Spread
NCT03547973 · Metastatic Urothelial Cancer
Phase 2 Active, closed Gilead Sciences UK, USA
A Study to Assess Overall Response Rate by Inducing an Inflammatory Phenotype in Metastatic BReast cAnCEr With the Oncolytic Reovirus PeLareorEp in CombinaTion With Anti-PD-L1 Avelumab and Paclitaxel - BRACELET-1 Study
NCT04215146 · ClinicalTrials.gov ↗ · Breast Cancer Metastatic
Phase 2 Active, closed Oncolytics Biotech USA
A Study of the Safety and Efficacy of Various Combinations of Avelumab as Therapy in Locally Advanced or Metastatic Urothelial Carcinoma (JAVELIN Bladder Medley)
NCT05327530 · ClinicalTrials.gov ↗ · Locally Advanced or Metastatic Urothelial Carcinoma
Phase 2 Active, closed EMD Serono Research & Development Institute, Inc. UK, USA, China
Study BT8009-230 in Participants With Locally Advanced or Metastatic Urothelial Cancer (Duravelo-2)
NCT06225596 · ClinicalTrials.gov ↗ · Metastatic Urothelial Cancer
Phase 2 Active, closed BicycleTx Limited UK, USA, China
Phase Ib/II of TG4001 and Avelumab in HPV16 Positive R/M Cancers
NCT03260023 · ClinicalTrials.gov ↗ · HPV-Related Carcinoma, HPV-Related Cervical Carcinoma, HPV-Related Anal Squamous Cell Carcinoma
Phase 1/2 Active, closed Transgene USA
A Study of XL092 as Single-Agent and Combination Therapy in Subjects With Solid Tumors
NCT03845166 · ClinicalTrials.gov ↗ · Neoplasm Malignant, Renal Cell Carcinoma, Hormone Receptor Positive Breast Carcinoma
Phase 1 Active, closed Exelixis UK, USA
A Study to Assess a PI3Kฮด Inhibitor (IOA-244) in Patients With Metastatic Cancers
NCT04328844 · ClinicalTrials.gov ↗ · Solid Tumor, Adult, Non-Hodgkin Lymphoma, Adult, NSCLC
Phase 1 Active, closed iOnctura UK
Oncolytic Adenovirus TILT-123 and Avelumab for Treatment of Solid Tumors Refractory to or Progressing After Anti-PD(L)1
NCT05222932 · ClinicalTrials.gov ↗ · Melanoma, Head and Neck Squamous Cell Carcinoma
Phase 1 Active, closed TILT Biotherapeutics Ltd. USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Avelumab

31 conditions
Metastatic Urothelial Cancer2NSCLC2Head and Neck Squamous Cell Carcinoma2Non-Small Cell Lung Cancer2Metastatic Renal Cell Carcinoma1Stage III Renal Cell Cancer AJCC v81Stage IV Renal Cell Cancer AJCC v81Unresectable Renal Cell Carcinoma1Solid Tumors1Neoplasm Malignant1Renal Cell Carcinoma1Hormone Receptor Positive Breast Carcinoma1
All 31 conditions
Condition (as registered)Trials
Metastatic Urothelial Cancer2
NSCLC2
Head and Neck Squamous Cell Carcinoma2
Non-Small Cell Lung Cancer2
Metastatic Renal Cell Carcinoma1
Stage III Renal Cell Cancer AJCC v81
Stage IV Renal Cell Cancer AJCC v81
Unresectable Renal Cell Carcinoma1
Solid Tumors1
Neoplasm Malignant1
Renal Cell Carcinoma1
Hormone Receptor Positive Breast Carcinoma1
Metastatic Castration-resistant Prostate Cancer1
Advanced Malignancies1
Ovarian Cancer1
Urothelial Cancer1
Solid Tumor, Adult1
Non-Hodgkin Lymphoma, Adult1
Myelofibrosis1
Locally Advanced or Metastatic Urothelial Carcinoma1
Melanoma1
Breast Cancer Metastatic1
Advanced Solid Tumor1
Metastatic Cancer1
Cutaneous Melanoma1
Small Cell Lung Cancer1
Urothelial Carcinoma1
HPV-Related Carcinoma1
HPV-Related Cervical Carcinoma1
HPV-Related Anal Squamous Cell Carcinoma1
HPV-Related Penile Squamous Cell Carcinoma1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
EMD Serono Research & Development Institute, Inc.2
NRG Oncology1
Gilead Sciences1
BicycleTx Limited1
Exelixis1
Pfizer1
iOnctura1
TILT Biotherapeutics Ltd.1
Oncolytics Biotech1
Aulos Bioscience, Inc.1
ImmunityBio, Inc.1
Transgene1
04

By country register

RegisterTrialsRecruiting
Clinical trials in USA111
Clinical trials in UK70
Clinical trials in China20
Clinical trials in Ireland11

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about Avelumab trials

How many clinical trials are testing Avelumab?

13 current trials in our USA, UK, China and Ireland registers name Avelumab as a drug or biological intervention, as of the registry sync on 25 September 2026. Completed and withdrawn studies are not counted.

Are Avelumab trials recruiting patients?

Yes. 2 of the 13 trials are recruiting: 1 with sites in USA and 1 with sites in Ireland. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Avelumab clinical trials?

EMD Serono Research & Development Institute, Inc (2), NRG Oncology (1), Gilead Sciences (1) and BicycleTx Limited (1), among 12 lead sponsors in total. The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Avelumab works or whether it is effective, and it is not medical advice.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Avelumab works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Avelumab (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 25 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.