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Compound · clinical trials

Folfiri clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 22 trials in our China, USA, UK, Ireland and India registers that name Folfiri as an intervention. Synced 25 Sep 2026
22Current trials
15Recruiting now
21Lead sponsors
5Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

Folfiri is named as an intervention in 22 current clinical trials in our China, USA, UK, Ireland and India registers. 15 are recruiting patients now. The most common phase is Phase 2. The sponsor with the most trials is Incyte Corporation (2). The most-studied condition is Metastatic Colorectal Cancer.

Trials by status

  • Recruiting1568%
  • Not yet open15%
  • Active, closed523%
  • By invitation15%

Trials by phase

  • Phase 2836%
  • Phase 1732%
  • Phase 3418%
  • Phase 1/229%
  • Phase 2/315%
01

Clinical trials of Folfiri

22 trials
StudyPhaseStatusLead sponsorRegisters
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naรฏve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
NCT06252649 · ClinicalTrials.gov ↗ · Metastatic Colorectal Cancer
Phase 3 Recruiting Amgen UK, USA, China
Study of Petosemtamab Plus Chemotherapy Versus Cetuximab Plus Chemotherapy in RAS and BRAF Wild-type, Unresectable or Metastatic, Left-sided Colorectal Cancer (LiGeR-CRC1)
NCT07702032 · Left-sided Colorectal Cancer
Phase 3 Recruiting Genmab USA
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
NCT07221357 · ClinicalTrials.gov ↗ · Untreated, Unresectable, or Metastatic Colorectal Cancer
Phase 2/3 Recruiting Bristol-Myers Squibb UK, USA, India, China
A Study on the Efficacy and Safety of Multi-mode Ablation Combined With Systemic Therapy in the Treatment of CRCLM
NCT06590259 · ClinicalTrials.gov ↗ · Colorectal Cancer Liver Metastasis
Phase 2 Recruiting Shanghai 6th People's Hospital China
Irinotecan Hydrochloride Liposome Injection (โ…ก) Combined with Fluorouracil, Folinic Acid, Vermofenib and Cetuximab in First-line Treatment of BRAFV600E Mutated Advanced Colorectal Cancer
NCT06603376 · ClinicalTrials.gov ↗ · Colorectal Carcinoma
Phase 2 Recruiting Shanghai Changzheng Hospital China
Standard Second-line Therapy With ONgericimab and TOripalimab in pMMR/MSS Colorectal Cancer: a Single-arm Phase II Trial
NCT07106034 · ClinicalTrials.gov ↗ · Advanced Colorectal Cancer
Phase 2 Recruiting Shanghai Pudong Hospital China
FOLFIRI and Bevacizumab With or Without Pelareorep for Second-Line Treatment of Metastatic RAS-Mutated, Microsatellite-Stable Colorectal Cancer
NCT07446322 · Ras-mutated Metastatic Colorectal Cancer, mCRC, MSS Metastatic Colorectal Cancer
Phase 2 Recruiting Oncolytics Biotech USA
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
NCT05786924 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer, Histiocytic Neoplasm, Histiocytosis
Phase 1/2 Recruiting Institut de Recherches Internationales Servier China
HSK42360-Na Tablets Combined With Cetuximab With or Without Chemotherapy in BRAF V600-Mutant Metastatic Colorectal Cancer
NCT07790510 · ClinicalTrials.gov ↗ · Metastatic Colorectal Cancer (CRC)
Phase 1/2 Recruiting Haisco Pharmaceutical Group Co., Ltd. China
alloSHRINK - Standard cHemotherapy Regimen and Immunotherapy With Allogeneic NKG2D-based CYAD-101 Chimeric Antigen Receptor T-cells
NCT03692429 · ClinicalTrials.gov ↗ · Unresectable Metastatic Colorectal Cancer
Phase 1 Recruiting Celyad Oncology SA USA
A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
NCT04929223 · ClinicalTrials.gov ↗ · Metastatic Colorectal Cancer
Phase 1 Recruiting Hoffmann-La Roche UK, USA
A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors
NCT05836324 · ClinicalTrials.gov ↗ · Solid Tumors, Advanced Solid Tumors, Metastatic Solid Tumors
Phase 1 Recruiting Incyte Corporation UK, USA, China
A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
NCT06179160 · ClinicalTrials.gov ↗ · Solid Tumors
Phase 1 Recruiting Incyte Corporation USA
Phase Ib Trial of HS-20117 in Combination With Other Drugs in Advanced Solid Tumors
NCT06621563 · ClinicalTrials.gov ↗ · Solid Tumors, Non-Small Cell Lung Cancer, Colorectal Cancer
Phase 1 Recruiting Hansoh BioMedical R&D Company China
A Study of JNJ-89402638 for Metastatic Colorectal and Gastric Cancers
NCT06663319 · Colorectal Neoplasms, Gastrointestinal Neoplasms
Phase 1 Recruiting Janssen Research & Development, LLC USA
FOLFIRI Plus Bevacizuamb and QL1706 in Second-Line Treatment for mCRC
NCT07729605 · ClinicalTrials.gov ↗ · Colorectal Cancer Metastatic, Microsatellite Stable (MSS) Colorectal Cancer (CRC)
Phase 3 Not yet open Sun Yat-sen University China
The Efficacy and Safety of IBI351, Cetuximab ฮฒ Combined With FOLFIRI as First-line /IBI351, Cetuximab ฮฒ as Second-line in the Treatment of KRAS G12C-mutated Metastatic Colorectal Cancer
NCT06959589 · ClinicalTrials.gov ↗ · Colorectal Cancer Metastatic, KRAS G12C Mutation
Phase 2 By invitation Second Affiliated Hospital, Zhejiang University, School of Medicine China
Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)
NCT04793958 · ClinicalTrials.gov ↗ · Advanced Colorectal Cancer, Metastatic Colorectal Cancer
Phase 3 Active, closed Mirati Therapeutics Inc. Ireland, UK, USA, China
A Study of PM8002 in Combination With Chemotherapy in Patients With NEN
NCT05879055 · ClinicalTrials.gov ↗ · Neuroendocrine Neoplasm
Phase 2 Active, closed Biotheus Inc. China
Liposomal Irinotecan Based FOLFIRI With Bevacizumab in First-line Treatment of Advanced Colorectal Cancer
NCT05969899 · ClinicalTrials.gov ↗ · Colorectal Cancer
Phase 2 Active, closed Fudan University China
Study of Onvansertib in Combination With FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab Versus FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer in Adult Participants With a KRAS or NRAS Mutation
NCT06106308 · ClinicalTrials.gov ↗ · Metastatic Colorectal Cancer, CRC, KRAS/NRAS Mutation
Phase 2 Active, closed Cardiff Oncology USA
TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers
NCT04485013 · Cancer
Phase 1 Active, closed Tizona Therapeutics, Inc USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Folfiri

29 conditions
Metastatic Colorectal Cancer4Solid Tumors3Advanced Colorectal Cancer2Colorectal Cancer Metastatic2Colorectal Cancer2Untreated, Unresectable, or Metastatic Colorectal Cancer1Advanced Solid Tumors1Metastatic Solid Tumors1Left-sided Colorectal Cancer1Cancer1Ras-mutated Metastatic Colorectal Cancer1mCRC1
All 29 conditions
Condition (as registered)Trials
Metastatic Colorectal Cancer4
Solid Tumors3
Advanced Colorectal Cancer2
Colorectal Cancer Metastatic2
Colorectal Cancer2
Untreated, Unresectable, or Metastatic Colorectal Cancer1
Advanced Solid Tumors1
Metastatic Solid Tumors1
Left-sided Colorectal Cancer1
Cancer1
Ras-mutated Metastatic Colorectal Cancer1
mCRC1
MSS Metastatic Colorectal Cancer1
Colorectal Neoplasms1
Gastrointestinal Neoplasms1
Unresectable Metastatic Colorectal Cancer1
CRC1
KRAS/NRAS Mutation1
Microsatellite Stable (MSS) Colorectal Cancer (CRC)1
Metastatic Colorectal Cancer (CRC)1
Non-small Cell Lung Cancer1
Histiocytic Neoplasm1
Histiocytosis1
BRAF Gene Mutation1
Colorectal Cancer Liver Metastasis1
Neuroendocrine Neoplasm1
Non-Small Cell Lung Cancer1
Colorectal Carcinoma1
KRAS G12C Mutation1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Incyte Corporation2
Mirati Therapeutics Inc.1
Amgen1
Bristol-Myers Squibb1
Hoffmann-La Roche1
Genmab1
Tizona Therapeutics, Inc1
Oncolytics Biotech1
Janssen Research & Development, LLC1
Celyad Oncology SA1
Cardiff Oncology1
Sun Yat-sen University1
Shanghai Pudong Hospital1
Haisco Pharmaceutical Group Co., Ltd.1
Institut de Recherches Internationales Servier1

+ 6 more sponsors in the trial list above.

04

By country register

RegisterTrialsRecruiting
Clinical trials in China149
Clinical trials in USA129
Clinical trials in UK54
Clinical trials in Ireland10
Clinical trials in India11

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about Folfiri trials

How many clinical trials are testing Folfiri?

22 current trials in our China, USA, UK, Ireland and India registers name Folfiri as a drug or biological intervention, as of the registry sync on 25 September 2026. Completed and withdrawn studies are not counted.

Are Folfiri trials recruiting patients?

Yes. 15 of the 22 trials are recruiting: 9 with sites in China, 9 with sites in USA, 4 with sites in UK and 1 with sites in India. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Folfiri clinical trials?

Incyte Corporation (2), Mirati Therapeutics Inc (1), Amgen (1) and Bristol-Myers Squibb (1), among 21 lead sponsors in total. The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Folfiri works or whether it is effective, and it is not medical advice.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Folfiri works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Folfiri (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 25 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.