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Compound · clinical trials

AK117

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 7 trials in our China and USA registers that name AK117 as an intervention. Synced 24 Sep 2026
7Trials tracked
2Recruiting now
2Lead sponsors
2Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards

AK117 is named as a drug or biological intervention in 7 clinical trials in our China and USA trial registers, 2 of which are recruiting. Lead sponsors include Akeso (6) and West China Hospital (1). Registered phases: Phase 2, Phase 1/2 and Phase 3. Conditions studied include Head and Neck Squamous Cell Carcinoma; Metastatic Colorectal Cancer; Higher-risk Myelodysplastic Syndromes.

01

Clinical trials of AK117

7 trials
NCT IDStudyPhaseStatusLead sponsorRegister
NCT06601335 A Phase 3 Study of AK112 Plus AK117 Versus Pembrolizumab in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (ClinicalTrials.gov ↗)
Head and Neck Squamous Cell Carcinoma
Phase 3 Recruiting Akeso China
NCT06196203 A Study of AK117 in Combination With Azacitidine in Patients With Myelodysplastic Syndromes (ClinicalTrials.gov ↗)
Higher-risk Myelodysplastic Syndromes
Phase 2 Recruiting Akeso USA, China
NCT05227664 A Study of AK117/AK112 in Metastatic Triple-Negative Breast Cancer (ClinicalTrials.gov ↗)
Metastatic Triple-negative Breast Cancer, Locally Advanced Triple-negative Breast Cancer
Phase 2 Active, closed Akeso China
NCT05382442 A Study of AK112 With or Without AK117 in Metastatic Colorectal Cancer (ClinicalTrials.gov ↗)
Metastatic Colorectal Cancer
Phase 2 Active, closed Akeso USA, China
NCT06508606 AK117 (Anti-CD47 mAb) Plus Cetuximab or AK104 (Anti-PD-1/CTLA-4 bsAb) as Second-Line Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (ClinicalTrials.gov ↗)
Head and Neck Squamous Cell Carcinoma
Phase 2 Active, closed West China Hospital China
NCT04900350 A Trial of AK117 (Anti-CD47) in Patients With Myelodysplastic Syndrome (ClinicalTrials.gov ↗)
Myelodysplastic Syndrome
Phase 1/2 Active, closed Akeso China
NCT05229497 A Phase Ib/II Study of AK112 in Combination With AK117 in Advanced Malignant Tumors (ClinicalTrials.gov ↗)
Advanced Malignant Tumors
Phase 1/2 Active, closed Akeso China

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied

7 conditions
Condition (as registered)Trials
Head and Neck Squamous Cell Carcinoma2
Metastatic Colorectal Cancer1
Higher-risk Myelodysplastic Syndromes1
Metastatic Triple-negative Breast Cancer1
Locally Advanced Triple-negative Breast Cancer1
Myelodysplastic Syndrome1
Advanced Malignant Tumors1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Akeso6
West China Hospital1
04

Trials by country register

A trial with sites in more than one country appears in each of those registers.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how AK117 works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists AK117 (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 24 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.