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Compound · clinical trials

Trastuzumab emtansine

Also listed in trial records as T-DM1, Ado-trastuzumab emtansine, Kadcyla
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 18 trials in our China, USA, UK, Ireland and India registers that name Trastuzumab emtansine as an intervention. Synced 24 Sep 2026
18Trials tracked
6Recruiting now
14Lead sponsors
5Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards

Trastuzumab emtansine is named as a drug or biological intervention in 18 clinical trials in our China, USA, UK, Ireland and India trial registers, 6 of which are recruiting. Lead sponsors include Hoffmann-La Roche (3), Daiichi Sankyo (2) and Fudan University (2). Registered phases: Phase 3, Phase 2, Phase 1/2, Phase 1 and Observational. Conditions studied include HER2-positive Breast Cancer; Breast Cancer; Metastatic Breast Cancer.

01

Clinical trials of Trastuzumab emtansine

18 trials
NCT IDStudyPhaseStatusLead sponsorRegister
NCT06313086 DP303c Versus Trastuzumab Emtansine in in Patients With HER2-positive Advanced Breast Cancer (ClinicalTrials.gov ↗)
HER2-positive Breast Cancer
Phase 3 Recruiting CSPC ZhongQi Pharmaceutical Technology Co., Ltd. China
NCT06830889 A Study of BL-M07D1 Versus T-DM1 in the Adjuvant Treatment of HER2-positive Breast Cancer With Residual Invasive Cancer After Neoadjuvant Therapy (ClinicalTrials.gov ↗)
HER2-positive Breast Cancer
Phase 3 Recruiting Sichuan Baili Pharmaceutical Co., Ltd. China
NCT07008976 Clinical Trial of TQB2102 for Injection Versus Trastuzumab Emtansine for Injection in HER2-positive Advanced Breast Cancer (ClinicalTrials.gov ↗)
Metastatic Breast Cancer
Phase 3 Recruiting Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. China
NCT07673029 A Trial Comparing GQ1005 and T-DM1 in Patients With HER2-Positive Unresectable or Metastatic Breast Cancer (ClinicalTrials.gov ↗)
HER2-positive Breast Cancer
Phase 3 Recruiting GeneQuantum Healthcare (Suzhou) Co., Ltd. China
NCT06324357 Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
Metastatic Breast Cancer, Metastatic Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
Phase 1/2 Recruiting Boehringer Ingelheim UK, USA, China
NCT07389876 Albumin-bound Paclitaxel-based Second-line Treatment Regimens for Locally Advanced or Metastatic G/GEJ Adenocarcinoma (ClinicalTrials.gov ↗)
Gastric Cancer, Second-line Treatment
Observational Recruiting Fudan University China
NCT07825753 Protein-Matched ADC or PDC Umbrella Trial in Advanced Pancreatic and Breast Cancer (ClinicalTrials.gov ↗)
Advanced or Metastatic Pancreatic Adenocarcinoma, Advanced or Metastatic Breast Cancer (BC)
Phase 2 Not yet open Fudan University China
NCT03529110 DS-8201a Versus T-DM1 for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive, Unresectable and/or Metastatic Breast Cancer Previously Treated With Trastuzumab and Taxane [DESTINY-Breast03] (ClinicalTrials.gov ↗)
Breast Cancer
Phase 3 Active, closed Daiichi Sankyo UK, USA, China
NCT03975647 A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer (ClinicalTrials.gov ↗)
HER2-positive Breast Cancer
Phase 3 Active, closed Seagen, a wholly owned subsidiary of Pfizer UK, USA, China
NCT04622319 A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05) (ClinicalTrials.gov ↗)
HER2-Positive Primary Breast Cancer, Residual Invasive Breast Cancer
Phase 3 Active, closed Daiichi Sankyo Ireland, UK, USA, China
NCT04873362 A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy (ClinicalTrials.gov ↗)
Breast Cancer
Phase 3 Active, closed Hoffmann-La Roche UK, USA, India, China
NCT06265428 A Study to Compare DB-1303/BNT323 Versus T-DM1 in Breast Cancer (ClinicalTrials.gov ↗)
HER2-positive Breast Cancer
Phase 3 Active, closed DualityBio Inc. China
NCT00781612 A Safety Extension Study of Trastuzumab Emtansine in Participants Previously Treated With Trastuzumab Emtansine Alone or in Combination With Other Anti-Cancer Therapy in One of the Parent Studies (ClinicalTrials.gov ↗)
Neoplasm Metastasis
Phase 2 Active, closed Genentech, Inc. UK, USA, China
NCT04398914 Pyrotinib, Trastuzumab, Pertuzumab and Nab-paclitaxel as Neoadjuvant Therapy in HER2-positive Breast Cancer (ClinicalTrials.gov ↗)
Breast Cancer Invasive
Phase 2 Active, closed Shanghai Jiao Tong University School of Medicine China
NCT04589845 Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study
Solid Tumors
Phase 2 Active, closed Hoffmann-La Roche UK, USA, China
NCT04931342 A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors (ClinicalTrials.gov ↗)
Ovarian Cancer
Phase 2 Active, closed Hoffmann-La Roche UK, USA
NCT05081609 A Study to Investigate Safety and Tolerability of TransCon IL-2 ฮฒ/ฮณ Alone or in Combination With Pembrolizumab and/or TransCon TLR7/8 Agonist or Other Anticancer Therapies in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies (ClinicalTrials.gov ↗)
Advanced Solid Tumor, Locally Advanced Solid Tumor, Metastatic Solid Tumor
Phase 1/2 Active, closed Ascendis Pharma Oncology Division A/S USA
NCT05650879 ELVN-002 in HER2 Mutant Non-Small Cell Lung Cancer
HER2 Mutant Non-small Cell Lung Cancer, HER2-positive Metastatic Breast Cancer, HER2 Gene Mutation
Phase 1 Active, closed Enliven Therapeutics USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied

24 conditions
Condition (as registered)Trials
HER2-positive Breast Cancer5
Breast Cancer2
Metastatic Breast Cancer2
HER2-Positive Primary Breast Cancer1
Residual Invasive Breast Cancer1
HER2 Mutant Non-small Cell Lung Cancer1
HER2-positive Metastatic Breast Cancer1
HER2 Gene Mutation1
HER2 Amplification1
Advanced Solid Tumor1
Locally Advanced Solid Tumor1
Metastatic Solid Tumor1
Platinum-resistant Ovarian Cancer1
Advanced or Metastatic Pancreatic Adenocarcinoma1
Advanced or Metastatic Breast Cancer (BC)1
Breast Cancer Invasive1
Metastatic Gastric Adenocarcinoma1
Gastroesophageal Junction Adenocarcinoma1
Esophageal Adenocarcinoma1
Solid Tumors1
Neoplasm Metastasis1
Ovarian Cancer1
Gastric Cancer1
Second-line Treatment1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Hoffmann-La Roche3
Daiichi Sankyo2
Fudan University2
Seagen, a wholly owned subsidiary of Pfizer1
Enliven Therapeutics1
Ascendis Pharma Oncology Division A/S1
DualityBio Inc.1
GeneQuantum Healthcare (Suzhou) Co., Ltd.1
Sichuan Baili Pharmaceutical Co., Ltd.1
Shanghai Jiao Tong University School of Medicine1
Boehringer Ingelheim1
Genentech, Inc.1
Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.1
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.1
04

Trials by country register

A trial with sites in more than one country appears in each of those registers.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Trastuzumab emtansine works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Trastuzumab emtansine (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 24 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.