The ABC-HCC Trial: Atezolizumab Plus Bevacizumab vs. Transarterial Chemoembolization (TACE) in Intermediate-stage HepatoCellular Carcinoma
NCT04803994 · ClinicalTrials.gov ↗ · Hepatocellular Carcinoma
|
Phase 3 |
Recruiting |
Institut fรผr Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest |
Germany, France, Spain, Italy, Austria, Japan |
Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity
NCT04273061 · ClinicalTrials.gov ↗ · Breast Cancer, Lung Cancer, Gastrointestinal Cancer
|
Phase 2 |
Recruiting |
British Columbia Cancer Agency |
Canada |
ProTarget - A Danish Nationwide Clinical Trial on Targeted Cancer Treatment Based on Genomic Profiling
NCT04341181 · ClinicalTrials.gov ↗ · Cancer, Tumors, Neoplasms
|
Phase 2 |
Recruiting |
Ulrik Lassen |
Denmark |
|
PLATFORM Study of Precision Medicine for Rare Tumors
|
Phase 2 |
Recruiting |
Cancer Institute and Hospital, Chinese Academy of Medical Sciences |
China |
A Prospective, Randomized, Multicenter, Comparative Study of the Efficacy of Imatinib Resumption Combined With Atezolizumab Versus Imatinib Resumption Alone in Patients With Unresectable Advanced Gastrointestinal Stromal Tumors (GIST) After Failure of Standard Treatments
NCT05152472 · ClinicalTrials.gov ↗ · Unresectable Gastrointestinal Stromal Tumor (GIST), Locally Advanced Gastrointestinal Stromal Tumor (GIST), Metastatic Gastrointestinal Stromal Tumor
|
Phase 2 |
Recruiting |
Centre Leon Berard |
France |
Genomics Guided Targeted Post-neoadjuvant Therapy in Patients With Early Breast Cancer (COGNITION-GUIDE)
NCT05332561 · ClinicalTrials.gov ↗ · Early-stage Breast Cancer
|
Phase 2 |
Recruiting |
German Cancer Research Center |
Germany |
Tiragolumab and Atezolizumab in Advanced Pan-cancer Patients
NCT06003621 · ClinicalTrials.gov ↗ · Solid Tumor, Adult
|
Phase 2 |
Recruiting |
Omico |
Australia |
NOvel Immunotherapy Strategies for Advanced Triple Negative Breast Cancer (TNBC) Patients: TONIC-3 Trial
NCT06342037 · ClinicalTrials.gov ↗ · Metastatic Breast Cancer
|
Phase 2 |
Recruiting |
The Netherlands Cancer Institute |
Netherlands |
Neoadjuvant Treatment With Atezolizumab and Atezolizumab as Maintenance for the Treatment of Stage III Non Small-Cell Lung Cancer (NSCLC)
NCT07153445 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer, Stage IIIA Lung Cancer, Stage IIIB Lung Cancer
|
Phase 2 |
Recruiting |
Fundaciรณn GECP |
Spain |
Quaratusugene Ozeplasmid (Reqorsa) and Atezolizumab Maintenance Therapy in ES-SCLC Patients
NCT05703971 · ClinicalTrials.gov ↗ · Small Cell Lung Cancer Extensive Stage
|
Phase 1/2 |
Recruiting |
Genprex, Inc |
USA |
Using Radiotherapy and Immunotherapy to Treat Advanced Liver Cancer Before Transplant
NCT06725121 · ClinicalTrials.gov ↗ · Hepatocellular Carcinoma (HCC), Macrovascular Invasion, Liver Transplant Surgery
|
Phase 1/2 |
Recruiting |
University Health Network, Toronto |
Canada |
A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
NCT04929223 · ClinicalTrials.gov ↗ · Metastatic Colorectal Cancer
|
Phase 1 |
Recruiting |
Hoffmann-La Roche |
UK, USA, Germany, Spain, Italy, Denmark, Poland, Canada, South Korea, Taiwan, Australia |
Atezolizumab+Bevacizumab+SBRT in Unresectable HCC
NCT05096715 · ClinicalTrials.gov ↗ · Unresectable Hepatocellular Carcinoma
|
Phase 1 |
Recruiting |
Massachusetts General Hospital |
Israel |
LB-100 (PP2A Inhibitor) and Atezolizumab (PD-L1 Inhibitor) in Metastatic Colorectal Cancer Patients
NCT06012734 · ClinicalTrials.gov ↗ · Metastatic Microsatellite-stable Colorectal Cancer
|
Phase 1 |
Recruiting |
The Netherlands Cancer Institute |
Netherlands |
KPMNG Study of MOlecular Profiling Guided Therapy Based on Genomic Alterations in Advanced Solid Tumors II
NCT05525858 · ClinicalTrials.gov ↗ · Solid Tumor, Advanced Solid Tumor, Metastatic Cancer
|
Observational |
Recruiting |
Seoul National University Bundang Hospital |
South Korea |
Pemetrexed-free vs. Pemetrexed-based Immunochemotherapy in Metastatic TTF-1 Negative Lung Adenocarcinoma
NCT05689671 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer Metastatic
|
Phase 4 |
Active, closed |
Nikolaj Frost MD |
Germany |
Study to Assess Safety and Efficacy of Atezolizumab (MPDL3280A) Compared to Best Supportive Care Following Chemotherapy in Patients With Lung Cancer [IMpower010]
NCT02486718 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer
|
Phase 3 |
Active, closed |
Hoffmann-La Roche |
UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Portugal, Japan, South Korea, Taiwan, Australia, Israel |
|
A Study in Participants Previously Enrolled in a Genentech- and/or F. Hoffmann-La Roche Ltd-Sponsored Atezolizumab Study (IMbrella A)
|
Phase 3 |
Active, closed |
Hoffmann-La Roche |
UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Switzerland, Austria, Czechia, Portugal, Turkey, Canada, Brazil, Japan, South Korea, Taiwan, Australia, Israel |
Neoadjuvant Treatment of HER2 Positive Early High-risk and Locally Advanced Breast Cancer
NCT03595592 · ClinicalTrials.gov ↗ · Invasive Breast Cancer
|
Phase 3 |
Active, closed |
Fondazione Michelangelo |
Germany, Spain, Italy, Austria |
|
Atezolizumab Plus One-year BCG Bladder Instillation in BCG-naive High-risk Non-muscle Invasive Bladder Cancer Patients
|
Phase 3 |
Active, closed |
UNICANCER |
France, Spain, Belgium |
Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC
NCT04446117 · ClinicalTrials.gov ↗ · Metastatic Prostate Cancer, Prostate Adenocarcinoma
|
Phase 3 |
Active, closed |
Exelixis |
UK, USA, Germany, France, Spain, Italy, Belgium, Poland, Austria, Czechia, Portugal, Canada, Brazil, Mexico, Japan, South Korea, Taiwan, Singapore, Australia, Israel |
|
A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy
|
Phase 3 |
Active, closed |
Hoffmann-La Roche |
UK, USA, India, China, Germany, France, Spain, Italy, Belgium, Denmark, Poland, Austria, Czechia, Portugal, Turkey, Brazil, Mexico, South Korea, Taiwan, Singapore, Australia |
A Phase III, Open-Label Study of Maintenance Lurbinectedin in Combination With Atezolizumab Compared With Atezolizumab in Participants With Extensive-Stage Small-Cell Lung Cancer
NCT05091567 · ClinicalTrials.gov ↗ · Small-Cell Lung Cancer
|
Phase 3 |
Active, closed |
Hoffmann-La Roche |
UK, USA, Germany, Spain, Italy, Belgium, Poland, Turkey, Mexico, South Korea, Taiwan |
A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC) (IMbrave152)
NCT05904886 · ClinicalTrials.gov ↗ · Hepatocellular Carcinoma
|
Phase 3 |
Active, closed |
Hoffmann-La Roche |
UK, USA, China, Germany, France, Spain, Italy, Belgium, Sweden, Poland, Turkey, Canada, Brazil, Mexico, Japan, South Korea, Taiwan, Singapore |
A Safety Extension Study of Trastuzumab Emtansine in Participants Previously Treated With Trastuzumab Emtansine Alone or in Combination With Other Anti-Cancer Therapy in One of the Parent Studies
NCT00781612 · ClinicalTrials.gov ↗ · Neoplasm Metastasis
|
Phase 2 |
Active, closed |
Genentech, Inc |
UK, USA, China, Germany, France, Spain, Italy, Belgium, Denmark, Poland, Switzerland, Czechia, Norway, Portugal, Canada, Brazil, Mexico, Japan, South Korea, Taiwan, Australia, Israel |
Study of Atezolizumab + FLOT vs. FLOT Alone in Patients With GC/GEJ and High Immune Responsiveness
NCT03421288 · ClinicalTrials.gov ↗ · Gastric Cancer, Gastroesophageal Junction Adenocarcinoma
|
Phase 2 |
Active, closed |
Institut fรผr Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest |
Germany, Switzerland |
|
The Feasibility and Clinical Efficacy of Atezolizumab Consolidation Treatment in High Risk (IPI > 2) DLBCL
|
Phase 2 |
Active, closed |
Stichting Hemato-Oncologie voor Volwassenen Nederland |
Netherlands, Belgium |
Atezolizumab After Concurrent Chemo-radiotherapy Versus Chemo-radiotherapy Alone in Limited Disease Small-cell Lung Cancer
NCT03540420 · ClinicalTrials.gov ↗ · Small-cell Lung Cancer
|
Phase 2 |
Active, closed |
Norwegian University of Science and Technology |
Netherlands, Sweden, Denmark, Switzerland, Norway |
ObinutuzuMab AtezOlizumab and VenetocLax in RichTer transfOrmation
NCT04082897 · ClinicalTrials.gov ↗ · CLL Transformation
|
Phase 2 |
Active, closed |
Niguarda Hospital |
Italy, Switzerland |
|
Efficacy of Atezolizumab Concurrent With Radiotherapy in Patients With Muscle-invasive Bladder cรกncer
|
Phase 2 |
Active, closed |
Spanish Oncology Genito-Urinary Group |
Spain |
A Phase II Trial of PD-L1 Therapy Combined With Anti-VEGF Therapy in Unresectable or Metastatic Melanoma
NCT04356729 · ClinicalTrials.gov ↗ · Clinical Stage III Cutaneous Melanoma AJCC v8, Stage IV Melanoma, Unresectable Stage III Cutaneous Melanoma
|
Phase 2 |
Active, closed |
F. Stephen Hodi, MD |
Israel |
An Exploratory Study of Atezolizumab and Bevacizumab in Hepatocellular Carcinoma and Non-Small Cell Lung Cancer With Liver Metastases (INTEGRATE)
NCT04563338 · ClinicalTrials.gov ↗ · Hepatocellular Carcinoma, Non-small Cell Lung Cancer Metastatic, Liver Metastases
|
Phase 2 |
Active, closed |
University Health Network, Toronto |
Canada |
|
Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study
|
Phase 2 |
Active, closed |
Hoffmann-La Roche |
UK, USA, China, Germany, France, Spain, Italy, Belgium, Denmark, Poland, Switzerland, Portugal, Canada, Brazil, Mexico, Japan, South Korea, Taiwan, Singapore, Australia, Israel, Egypt |
|
Intravesical Recombinant BCG Followed by Perioperative Chemo-immunotherapy for Patients With MIBC
|
Phase 2 |
Active, closed |
Swiss Cancer Institute |
Switzerland |
|
Combination or Sequence of Vemurafenib, Cobimetinib, and Atezolizumab in High-risk, Resectable Melanoma
|
Phase 2 |
Active, closed |
Fondazione Melanoma Onlus |
Italy |
Neoadjuvant Atezo, Adjuvant Atezo + Beva Combined With RF Ablation of Small HCC: a Multicenter Randomized Phase II Trial
NCT04727307 · ClinicalTrials.gov ↗ · Hepatocellular Carcinoma
|
Phase 2 |
Active, closed |
University Hospital, Montpellier |
France |
Frontline Treatment of Follicular Lymphoma With AtezolizUmab and Obinutuzumab With and Without RadiOtherapy
NCT04962126 · ClinicalTrials.gov ↗ · Follicular Lymphoma
|
Phase 2 |
Active, closed |
Olivia Newton-John Cancer Research Institute |
Australia |
|
Atezolizumab in Patients With MSI-h/MMR-D Stage II High Risk and Stage III Colorectal Cancer Ineligible for Oxaliplatin
|
Phase 2 |
Active, closed |
AIO-Studien-gGmbH |
Germany |
Treatment of Atezolizumab and Derazantinib in Patients With Advanced iCCA With FGFR2 Fusions/Rearrangements
NCT05174650 · ClinicalTrials.gov ↗ · Intrahepatic Cholangiocarcinoma
|
Phase 2 |
Active, closed |
Institut fรผr Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest |
Germany |
Combination of Paclitaxel-bevacizumab ยฑ Atezolizumab in Patients With Advanced NSCLC Progressing After Immunotherapy & Chemotherapy
NCT05781308 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer
|
Phase 2 |
Active, closed |
Intergroupe Francophone de Cancerologie Thoracique |
France |
NeoTRACK - Dissection of IO Efficacy in NSCLC by Longitudinal tracKing
NCT05825625 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer
|
Phase 2 |
Active, closed |
Institut fรผr Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest |
Germany |
A Study of the Efficacy and Safety of Adjuvant Autogene Cevumeran Plus Atezolizumab and mFOLFIRINOX Versus mFOLFIRINOX Alone in Participants With Resected PDAC
NCT05968326 · ClinicalTrials.gov ↗ · Adenocarcinoma, Pancreatic Ductal
|
Phase 2 |
Active, closed |
Genentech, Inc |
UK, USA, Germany, France, Spain, Netherlands, Belgium, Sweden, Canada, South Korea |
A Study in Advanced or Metastatic Gastrointestinal Cancers Exploring Treatment Combinations With Pelareorep and Atezolizumab
NCT07280377 · ClinicalTrials.gov ↗ · Anal Cancer Metastatic, Squamous Cell Carcinoma of the Anus Stage Unspecified, Pancreatic Cancer Metastatic
|
Phase 1/2 |
Active, closed |
Oncolytics Biotech |
Germany |
Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors
NCT03170960 · ClinicalTrials.gov ↗ · Urothelial Carcinoma, Renal Cell Carcinoma, Non-Small Cell Lung Cancer
|
Phase 1 |
Active, closed |
Exelixis |
UK, USA, Germany, France, Spain, Italy, Netherlands, Belgium, Australia |
A MultIceNTER Phase I Peptide VaCcine Trial for the Treatment of H3-Mutated Gliomas
NCT04808245 · ClinicalTrials.gov ↗ · Newly Diagnosed H3-mutated Glioma
|
Phase 1 |
Active, closed |
German Cancer Research Center |
Germany |
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors
NCT05581004 · ClinicalTrials.gov ↗ · Locally Advanced or Metastatic Solid Tumors, NSCLC, HNSCC
|
Phase 1 |
Active, closed |
Genentech, Inc |
USA, Spain, Netherlands, Belgium, Sweden, Canada, South Korea, Taiwan, Australia |