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Compound · clinical trials

Tamoxifen clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 18 trials in our USA, China, UK, India and Ireland registers that name Tamoxifen as an intervention. Synced 25 Sep 2026
18Current trials
9Recruiting now
11Lead sponsors
5Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

Tamoxifen is named as an intervention in 18 current clinical trials in our USA, China, UK, India and Ireland registers. 9 are recruiting patients now. The most common phase is Phase 3. The sponsor with the most trials is Eli Lilly and Company (5). The most-studied condition is Breast Cancer.

Trials by status

  • Recruiting950%
  • Active, closed844%
  • By invitation16%

Trials by phase

  • Phase 31161%
  • Phase 2317%
  • Phase 1/216%
  • Phase 416%
  • Phase 116%
  • Not applicable16%
01

Clinical trials of Tamoxifen

18 trials
StudyPhaseStatusLead sponsorRegisters
Elacestrant for Treating ER+/HER2- Breast Cancer Patients With ctDNA Relapse (TREAT ctDNA)
NCT05512364 · ClinicalTrials.gov ↗ · ER-positive Breast Cancer, HER2-negative Breast Cancer, Stage IIB Breast Cancer
Phase 3 Recruiting European Organisation for Research and Treatment of Cancer - EORTC Ireland
A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy
NCT05774951 · ClinicalTrials.gov ↗ · Breast Cancer, Early Breast Cancer
Phase 3 Recruiting AstraZeneca UK, USA, India, China
Efficacy and Safety of Fluzoparib Combined With Adjuvant Endocrine Therapy for HR+/HER2- SNF3-subtype Early Breast Cancer (BCTOP-L-A01)
NCT05891093 · ClinicalTrials.gov ↗ · Breast Cancer
Phase 3 Recruiting Fudan University China
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
NCT06492616 · ClinicalTrials.gov ↗ · Breast Cancer
Phase 3 Recruiting Stemline Therapeutics, Inc. UK, USA, China
Omission of Adjuvant Radiotherapy in Low- and Intermediate-Risk Ductal Carcinoma In Situ After Breast-Conserving Surgery
NCT07762885 · ClinicalTrials.gov ↗ · Ductal Carcinoma In Situ, DCIS
Phase 3 Recruiting Fudan University China
A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)
NCT06979596 · Malignant Neoplasm
Phase 2 Recruiting Merck Sharp & Dohme LLC UK, USA
A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer
NCT07287098 · ClinicalTrials.gov ↗ · Breast Neoplasms
Phase 2 Recruiting Eli Lilly and Company Ireland, USA, China
First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors
NCT05768139 · ClinicalTrials.gov ↗ · Breast Cancer, Solid Tumors, Adult
Phase 1/2 Recruiting Eli Lilly and Company Ireland, USA
A Study of Chidamide Plus Endocrine in Maintenance Treatment of HR+/HER2- Breast Cancer After First-line Chemotherapy
NCT05890287 · ClinicalTrials.gov ↗ · HR Positive HER2 Negative Advanced Breast Cancer
Not applicable Recruiting Tianjin Medical University Cancer Institute and Hospital China
Safety Extension Study for Subjects With HR+, HER2- Breast Cancer for Subjects Who Have Completed the OVELIA Study
NCT05645536 · ClinicalTrials.gov ↗ · Breast Cancer
Phase 3 By invitation Tolmar Inc. USA, India
Roll-over Study to Allow Continued Access to Ribociclib
NCT05161195 · Metastatic Breast Cancer
Phase 4 Active, closed Novartis Pharmaceuticals USA, India, China
Ovarian Suppression Evaluating Subcutaneous Leuprolide Acetate in Breast Cancer
NCT04906395 · ClinicalTrials.gov ↗ · Breast Cancer
Phase 3 Active, closed Tolmar Inc. USA, India
A Study Evaluating the Efficacy and Safety of Giredestrant Plus Everolimus Compared With the Physician's Choice of Endocrine Therapy Plus Everolimus in Participants With Estrogen Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer (evERA Breast Cancer)
NCT05306340 · Estrogen Receptor (ER)-Positive, HER2-negative, Locally Advanced or Metastatic Breast Cancer
Phase 3 Active, closed Genentech, Inc. UK, USA
A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer
NCT05514054 · Breast Neoplasms
Phase 3 Active, closed Eli Lilly and Company Ireland, UK, USA, India, China
An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)
NCT05952557 · Breast Cancer, Early Breast Cancer
Phase 3 Active, closed AstraZeneca Ireland, UK, USA, India, China
A Study to Confirm if Fezolinetant Helps Reduce Hot Flashes in Women With Breast Cancer Who Are Having Hormone Therapy
NCT06440967 · Hot Flashes
Phase 3 Active, closed Astellas Pharma Global Development, Inc. UK
A Study of Abemaciclib (LY2835219) Plus Tamoxifen or Abemaciclib Alone in Women With Metastatic Breast Cancer
NCT02747004 · ClinicalTrials.gov ↗ · Metastatic Breast Cancer
Phase 2 Active, closed Eli Lilly and Company USA, China
A Study of LY2835219 (Abemaciclib) in Combination With Therapies for Breast Cancer That Has Spread
NCT02057133 · ClinicalTrials.gov ↗ · Breast Neoplasms
Phase 1 Active, closed Eli Lilly and Company USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Tamoxifen across our data

Ireland · EU · US

The same active substance in our other registers, matched by its exact name. Each entry links to the register record it comes from.

Licensed in Ireland (HPRA)

3 single-substance products containing Tamoxifen on the HPRA medicines list.

All 3 Irish products →

Supply shortages

No entry for Tamoxifen in the EMA, FDA or German BfArM shortage lists we track.

03

Conditions studied with Tamoxifen

14 conditions
Breast Cancer5Breast Neoplasms3Breast Cancer, Early Breast Cancer2Metastatic Breast Cancer2ER-positive Breast Cancer1HER2-negative Breast Cancer1Stage IIB Breast Cancer1Stage III Breast Cancer1Solid Tumors, Adult1Malignant Neoplasm1Hot Flashes1Estrogen Receptor (ER)-Positive, HER2-negative, Locally Advanced or Metastatic Breast Cancer1
All 14 conditions
Condition (as registered)Trials
Breast Cancer5
Breast Neoplasms3
Breast Cancer, Early Breast Cancer2
Metastatic Breast Cancer2
ER-positive Breast Cancer1
HER2-negative Breast Cancer1
Stage IIB Breast Cancer1
Stage III Breast Cancer1
Solid Tumors, Adult1
Malignant Neoplasm1
Hot Flashes1
Estrogen Receptor (ER)-Positive, HER2-negative, Locally Advanced or Metastatic Breast Cancer1
HR Positive HER2 Negative Advanced Breast Cancer1
Ductal Carcinoma In Situ, DCIS1
04

Sponsors

lead sponsor per trial
Lead sponsorTrials
Eli Lilly and Company5
AstraZeneca2
Tolmar Inc.2
Fudan University2
European Organisation for Research and Treatment of Cancer - EORTC1
Merck Sharp & Dohme LLC1
Astellas Pharma Global Development, Inc.1
Genentech, Inc.1
Stemline Therapeutics, Inc.1
Novartis Pharmaceuticals1
Tianjin Medical University Cancer Institute and Hospital1
05

By country register

RegisterTrialsRecruiting
Clinical trials in USA135
Clinical trials in China106
Clinical trials in UK73
Clinical trials in India61
Clinical trials in Ireland53

A trial with sites in more than one country appears in each of those registers.

06

Related compounds

07

Questions about Tamoxifen trials

How many clinical trials are testing Tamoxifen?

18 current trials in our USA, China, UK, India and Ireland registers name Tamoxifen as a drug or biological intervention, as of the registry sync on 25 September 2026. Completed and withdrawn studies are not counted.

Are Tamoxifen trials recruiting patients?

Yes. 9 of the 18 trials are recruiting: 5 with sites in USA, 6 with sites in China, 3 with sites in UK, 1 with sites in India and 3 with sites in Ireland. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Tamoxifen clinical trials?

Eli Lilly and Company (5), AstraZeneca (2), Tolmar Inc (2) and Fudan University (2), among 11 lead sponsors in total. The number in brackets is how many trials each organisation leads.

Is Tamoxifen licensed in Ireland?

Yes. The HPRA medicines list includes 3 single-substance products containing Tamoxifen, for example Tamox 10 mg Film-coated tablets (Rowex Limited,). A licence does not mean a product is currently marketed or reimbursed; see each product's record.

Is there a Tamoxifen shortage?

Not in the lists we track: Tamoxifen has no entry in the EMA, FDA or German BfArM shortage registers as of their latest sync.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Tamoxifen works or whether it is effective, and it is not medical advice.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Tamoxifen works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Tamoxifen (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 25 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.