Norepinephrine clinical trials
Norepinephrine is named as an intervention in 20 current clinical trials in our France, Egypt, Canada, China, Ireland, Italy, Spain, Israel, Japan, Brazil and South Korea registers. 16 are recruiting patients now. The most common phase is Not applicable. The sponsor with the most trials is Samuel Lunenfeld Research Institute, Mount Sinai Hospital (2). The most-studied condition is Intraoperative Hypotension. The EU clinical trials register (CTIS) separately lists 1 authorised or ongoing trial.
How Norepinephrine works
All drug targets →- Adrenergic receptor agonist AgonistTarget: Adrenergic receptor✓ In ChEMBL and the Guide to Pharmacology
- ShockPhase 3
- Acute kidney injuryPhase 3
- Chronic kidney diseasePhase 3
- Congenital heart diseasePhase 3
- Hepatorenal syndromePhase 3
- Hypotensive disorderPhase 3
- Ischemic strokePhase 3
- Major depressive disorderPhase 3
- Pulmonary hypertensionPhase 3
- Septic shockPhase 3
Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL1437, CC BY-SA 3.0. Targets checked against the IUPHAR/BPS Guide to PHARMACOLOGY (2026.3.1), ligand 505, CC BY-SA 4.0. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.
Patient leaflets for Norepinephrine
The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.
- UKUnited Kingdom: Search MHRA ProductsPatient information leaflets and SmPCs for UK-licensed products.
- USUnited States: Search DailyMedFDA-approved labels, including patient and medication guides.
Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.
Reference identifiers for Norepinephrine
- ATC code
- C01CA03
- ChEMBL
- CHEMBL1437
- DrugBank
- DB00368
- PubChem CID
- 439260
- CAS number
- 51-41-2
- FDA UNII
- X4W3ENH1CV
- Wikidata
- Q186242
- Wikipedia
- Norepinephrine
Codes that identify this medicine in other databases, from Wikidata (CC0), matched by its ChEMBL ID. The ATC code is the WHO classification of what the medicine is used for.
Trials by status
Trials by phase
Clinical trials of Norepinephrine
20 trialsRegisters list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.
Norepinephrine in the EU trials register (CTIS)
1 trialAuthorised or ongoing trials in the EU Clinical Trials Information System that list a product containing Norepinephrine. Many trials are registered in both CTIS and ClinicalTrials.gov, so these are shown separately rather than added to the count above. Trials with a site in Ireland are listed first.
| Study | Phase | Status | Sponsor | Countries |
|---|---|---|---|---|
|
ADRESS : Efficacy of the Alpha 2 agonist dexmedetomidine for sympathetic Deactivation in REfractory Septic Shock: a randomized, controlled trial
2025-524122-18-00 · CTIS ↗ · Not possible to specify
|
Phase 3 | Ongoing | Hospices Civils De Lyon | France |
Conditions studied with Norepinephrine
39 conditionsAll 39 conditions
| Condition (as registered) | Trials |
|---|---|
| Intraoperative Hypotension | 2 |
| Anesthesia | 2 |
| Hypotension | 2 |
| Norepinephrine | 2 |
| Critical Illness | 1 |
| Respiratory Failure | 1 |
| Late-Onset Neonatal Sepsis | 1 |
| Extreme Prematurity | 1 |
| Neonatal Hypotension | 1 |
| Pulmonary Arterial Hypertension (PAH) | 1 |
| Chronic Thromboembolic Pulmonary Hypertension (CTEPH) | 1 |
| Hypertension, Pulmonary | 1 |
| Blood Pressure | 1 |
| Coronary Artery Bypass, Off-Pump | 1 |
| Acute Kidney Injury | 1 |
| Preventive Medicine | 1 |
| Tumor | 1 |
| Stroke | 1 |
| Shock | 1 |
| Scheduled Cardiac Surgery With Extracorporeal Circulation | 1 |
| Vasoplegic Syndrome | 1 |
| Pulmonary Hypertension | 1 |
| Chronic Pulmonary Thromboembolism | 1 |
| Vasopressor | 1 |
| Acute Kidney Injury Post Liver Transplantation | 1 |
| Surgery With General Anesthesia | 1 |
| Noncardiac Surgery | 1 |
| Hypotension During Surgery | 1 |
| Postpartum Hemorrhage | 1 |
| Vasoplegic Syndrome of Cardiac Surgery | 1 |
| Cardiogenic Shock | 1 |
| Postoperative Pulmonary Complications (PPCs) | 1 |
| Fluid Over-load | 1 |
| Incidence of Post-spinal Hypotension | 1 |
| Patients Undergoing Orthopedic Hip Surgery Under Spinal Anesthesia | 1 |
| Orthopedic Hip Sugery in Eldely Patients | 1 |
| Cesarean Section | 1 |
| Hypotension on Induction | 1 |
| Emergency Surgery | 1 |
Sponsors
lead sponsor per trial+ 3 more sponsors in the trial list above.
By country register
A trial with sites in more than one country appears in each of those registers. CTIS does not publish a recruiting flag; its trials may also appear in the registers above.
Related compounds
Questions about Norepinephrine trials
How many clinical trials are testing Norepinephrine?
20 current trials in our France, Egypt, Canada, China, Ireland, Italy, Spain, Israel, Japan, Brazil and South Korea registers name Norepinephrine as a drug or biological intervention, as of the registry sync on 9 November 2026. Completed and withdrawn studies are not counted.
Are Norepinephrine trials recruiting patients?
Yes. 16 of the 20 trials are recruiting: 3 with sites in France, 4 with sites in Egypt, 4 with sites in Canada, 3 with sites in China, 2 with sites in Ireland, 1 with sites in Italy, 1 with sites in Spain, 1 with sites in Israel, 1 with sites in Brazil and 1 with sites in South Korea. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.
Who sponsors Norepinephrine clinical trials?
Samuel Lunenfeld Research Institute, Mount Sinai Hospital (2), Cairo University (2), University of Turin, Italy (1) and Mount Sinai Hospital, Canada (1), among 18 lead sponsors in total. The number in brackets is how many trials each organisation leads.
Are there Norepinephrine clinical trials in Ireland?
Yes. 2 trials in our Ireland register (ClinicalTrials.gov). Some may be the same study registered in both. See the Irish clinical trials register for sites and contacts.
Where does this information come from?
Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Norepinephrine works or whether it is effective, and it is not medical advice.
How this page is built
Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Norepinephrine works or whether it is effective. Each trial links to its own record so you can check it yourself.
- ClinicalTrials.gov (U.S. National Library of Medicine) ↗ Trial IDs, titles, intervention names and synonyms, phase, overall status, lead sponsor and conditions for every trial on this page
This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Norepinephrine (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 9 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.