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Compound · clinical trials

Phenylephrine clinical trials

Also listed in trial records as Metaoxedrin, NeoSynephrine
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 12 trials in our Canada, China, South Korea, Japan, Denmark, Singapore and Egypt registers that name Phenylephrine as an intervention. Synced 26 Sep 2026
12Current trials
9Recruiting now
10Lead sponsors
7Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

Phenylephrine is named as an intervention in 12 current clinical trials in our Canada, China, South Korea, Japan, Denmark, Singapore and Egypt registers. 9 are recruiting patients now. The most common phase is Not applicable. The sponsor with the most trials is Samuel Lunenfeld Research Institute, Mount Sinai Hospital (2). The most-studied condition is Hypotension.

Trials by status

  • Recruiting975%
  • Not yet open18%
  • Active, closed18%
  • By invitation18%

Trials by phase

  • Not applicable433%
  • Phase 4325%
  • Phase 3217%
  • Phase 2/318%
  • Phase 118%
  • Observational18%
01

Clinical trials of Phenylephrine

12 trials
StudyPhaseStatusLead sponsorRegisters
The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery
NCT06802224 · ClinicalTrials.gov ↗ · Anesthesia, Surgery With General Anesthesia, Noncardiac Surgery
Phase 4 Recruiting University of California, San Francisco Canada
Comparison of Norepinehrine Versus Phenylepherine Infusion for Prevention of Post-spinal Hypotension
NCT07662408 · ClinicalTrials.gov ↗ · Patients Undergoing Orthopedic Hip Surgery Under Spinal Anesthesia, Orthopedic Hip Sugery in Eldely Patients
Phase 4 Recruiting Sohag University Egypt
Outcome in Patients Treated With Endovascular Thrombectomy - optIMAL Blood Pressure Control 2 (OPTIMAL-BP 2)
NCT06677970 · ClinicalTrials.gov ↗ · Acute Ischemic Stroke
Phase 3 Recruiting Yonsei University South Korea
Vasopressor Impact on Brain Circulation, Organ Blood Flow and Tissue Oxygenation During Anesthesia
NCT06083948 · ClinicalTrials.gov ↗ · Hypotension
Phase 2/3 Recruiting University of Aarhus Denmark
Phenylephrine Tumescence for Hemostasis in Surgery for Burn Injury
NCT01731444 · ClinicalTrials.gov ↗ · Blood Loss, Surgical
Phase 1 Recruiting University of Manitoba Canada
POTS Adrenergic Ab (CIHR Aims #1&2)
NCT02673996 · ClinicalTrials.gov ↗ · Postural Tachycardia Syndrome
Observational Recruiting University of Calgary Canada
Effects of Ephedrine, Phenylephrine, Norepinephrine and Vasopressin on Contractility of Human Myometrium and Umbilical Vessels: An In-vitro Study
NCT04053478 · ClinicalTrials.gov ↗ · Hypotension
Not applicable Recruiting Samuel Lunenfeld Research Institute, Mount Sinai Hospital Canada
Effect of Ephedrine, Phenylepinephrine, and Norepinephrine on Myometrial Contractility in Pregnant People With Type II and Gestational Diabetes During Cesarean Section: An In-vitro Study
NCT06285396 · ClinicalTrials.gov ↗ · Postpartum Hemorrhage
Not applicable Recruiting Samuel Lunenfeld Research Institute, Mount Sinai Hospital Canada
Different Intraoperative Blood Pressure Management on Postoperative Cognitive Function in Tumor Patients๏ผˆPRECISION๏ผ‰
NCT06711432 · ClinicalTrials.gov ↗ · Tumor, Stroke
Not applicable Recruiting Zhejiang Cancer Hospital China
CompARing Between CO2 Phenylephrine and Phenylephrine Only Treatment in Patients With proGrEssing Cerebral infarctioN
NCT06770426 · ClinicalTrials.gov ↗ · Acute Ischemic Stroke
Phase 3 Not yet open Yonsei University South Korea
The GUARDIAN Trial - Vasopressor Sub-Study
NCT04934748 · ClinicalTrials.gov ↗ · Blood Pressure
Phase 4 By invitation The University of Texas Health Science Center, Houston China, Japan
Development of Advanced Double Intravenous Vasopressor Automated (ADIVA) System
NCT03620942 · ClinicalTrials.gov ↗ · Hypotension, Anesthesia
Not applicable Active, closed KK Women's and Children's Hospital Singapore

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Phenylephrine across our data

Ireland · EU · US

The same active substance in our other registers, matched by its exact name. Each entry links to the register record it comes from.

Licensed in Ireland (HPRA)

4 single-substance products containing Phenylephrine on the HPRA medicines list.

All 4 Irish products →

Supply shortages

  • Neosynephrin-POS 10%Germany (BfArM) · Production problem · 27 Apr 2026 to 31 Oct 2026
  • Neosynephrin-POS 10%Germany (BfArM) · Production problem · 27 Apr 2026 to 31 Oct 2026
  • Neosynephrin-POS 5%Germany (BfArM) · Production problem · 29 Apr 2026 to 31 Oct 2026
03

Conditions studied with Phenylephrine

14 conditions
Hypotension3Anesthesia2Acute Ischemic Stroke2Tumor1Stroke1Blood Pressure1Surgery With General Anesthesia1Noncardiac Surgery1Hypotension During Surgery1Blood Loss, Surgical1Postpartum Hemorrhage1Postural Tachycardia Syndrome1
All 14 conditions
Condition (as registered)Trials
Hypotension3
Anesthesia2
Acute Ischemic Stroke2
Tumor1
Stroke1
Blood Pressure1
Surgery With General Anesthesia1
Noncardiac Surgery1
Hypotension During Surgery1
Blood Loss, Surgical1
Postpartum Hemorrhage1
Postural Tachycardia Syndrome1
Patients Undergoing Orthopedic Hip Surgery Under Spinal Anesthesia1
Orthopedic Hip Sugery in Eldely Patients1
04

Sponsors

lead sponsor per trial
Lead sponsorTrials
Samuel Lunenfeld Research Institute, Mount Sinai Hospital2
Yonsei University2
Zhejiang Cancer Hospital1
The University of Texas Health Science Center, Houston1
University of Aarhus1
University of California, San Francisco1
University of Manitoba1
University of Calgary1
KK Women's and Children's Hospital1
Sohag University1
05

By country register

RegisterTrialsRecruiting
Clinical trials in Canada55
Clinical trials in China21
Clinical trials in South Korea21
Clinical trials in Japan10
Clinical trials in Denmark11
Clinical trials in Singapore10
Clinical trials in Egypt11

A trial with sites in more than one country appears in each of those registers.

06

Related compounds

07

Questions about Phenylephrine trials

How many clinical trials are testing Phenylephrine?

12 current trials in our Canada, China, South Korea, Japan, Denmark, Singapore and Egypt registers name Phenylephrine as a drug or biological intervention, as of the registry sync on 26 September 2026. Completed and withdrawn studies are not counted.

Are Phenylephrine trials recruiting patients?

Yes. 9 of the 12 trials are recruiting: 5 with sites in Canada, 1 with sites in China, 1 with sites in South Korea, 1 with sites in Denmark and 1 with sites in Egypt. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Phenylephrine clinical trials?

Samuel Lunenfeld Research Institute, Mount Sinai Hospital (2), Yonsei University (2), Zhejiang Cancer Hospital (1) and The University of Texas Health Science Center, Houston (1), among 10 lead sponsors in total. The number in brackets is how many trials each organisation leads.

Is Phenylephrine licensed in Ireland?

Yes. The HPRA medicines list includes 4 single-substance products containing Phenylephrine, for example Minims Phenylephrine Hydrochloride 2.5% w/v eye drops, solution (Bausch + Lomb Ireland Limited). A licence does not mean a product is currently marketed or reimbursed; see each product's record.

Is there a Phenylephrine shortage?

The registers we track list 3 entries for Phenylephrine: 3 German notices. Shortages are product- and country-specific; check with a pharmacist.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Phenylephrine works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Phenylephrine works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Phenylephrine (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 26 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.