Epinephrine clinical trials
Epinephrine is named as an intervention in 14 current clinical trials in our Canada, USA, Egypt, Switzerland, Turkey, Germany and China registers. 10 are recruiting patients now. The most common phase is Phase 2. The sponsor with the most trials is Merck Sharp & Dohme LLC (2). The most-studied condition is Advanced Solid Tumors. The EU clinical trials register (CTIS) separately lists 1 authorised or ongoing trial.
Where Epinephrine is approved
All regulators →Of the three regulators tracked here, the first to approve Epinephrine was the US, on 8 Jun 1951. It is approved in 3 of the 3 regulators tracked here.
From the regulators' own registers: FDA Drugs@FDA, the EMA medicines list and Health Canada's Notice of Compliance database. Dates are the first listed approval of a product containing only this substance; combination products and nationally authorised EU medicines are not counted.
Epinephrine patents and exclusivity
Expiry tracker →Protections still running for marketed products containing Epinephrine, as listed by the regulators. Expired patents and exclusivities, and discontinued products, are not shown.
- 27 listed patents; the last listed expires 17 Jan 2045 (US 12539283).
Reproduced from the FDA Orange Book and Purple Book (checked 8 Nov 2026) and the European Commission's Union Register of medicinal products (CC BY 4.0; the EU expiry date is calculated exactly as the Commission's register displays it). Listed patents and dates are as submitted to or published by the regulator and may not reflect litigation, invalidation, settlements, lapsed fees or later extensions. This is not legal advice or a freedom-to-operate opinion, and it does not say when a generic or biosimilar will launch.
What health systems spend on Epinephrine
All medicines →From NHSBSA Prescription Cost Analysis (Open Government Licence v3.0) and CMS State Drug Utilization Data. Both are gross amounts: neither system publishes its discounts or rebates per drug. Products combining several substances are not counted here.
How Epinephrine works
All drug targets →- Adrenergic receptor agonist AgonistTarget: Adrenergic receptor✓ In ChEMBL and the Guide to Pharmacology
- PainPhase 3
- Benign muscle neoplasmPhase 3
- BronchiolitisPhase 3
- Cardiac arrestPhase 3
- Gastric cancerPhase 3
- Head and neck squamous cell carcinomaPhase 3
- HemorrhoidPhase 3
- NeoplasmPhase 3
- Cognitive impairmentPhase 2/3
- Acute bronchiolitisPhase 2/3
Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL679, CC BY-SA 3.0. Targets checked against the IUPHAR/BPS Guide to PHARMACOLOGY (2026.3.1), ligand 479, CC BY-SA 4.0. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.
Patient leaflets for Epinephrine
The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.
- IEIreland: 3 products on the HPRA listEach product record links to the HPRA, which publishes the leaflet and SmPC.
- EUEuropean Union: EurneffyEMA product information: package leaflet and summary of product characteristics in every EU language.
- UKUnited Kingdom: Search MHRA ProductsPatient information leaflets and SmPCs for UK-licensed products.
- USUnited States: Search DailyMedFDA-approved labels, including patient and medication guides.
Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.
Reference identifiers for Epinephrine
- ChEMBL
- CHEMBL679
- DrugBank
- DB00668
- PubChem CID
- 139148732
- CAS number
- 51-43-4
- FDA UNII
- YKH834O4BH
- Wikidata
- Q132621
- Wikipedia
- Adrenaline
Codes that identify this medicine in other databases, from Wikidata (CC0), matched by its ChEMBL ID. The ATC code is the WHO classification of what the medicine is used for.
Trials by status
Trials by phase
Clinical trials of Epinephrine
14 trialsRegisters list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.
Epinephrine in the EU trials register (CTIS)
1 trialAuthorised or ongoing trials in the EU Clinical Trials Information System that list a product containing Epinephrine. Many trials are registered in both CTIS and ClinicalTrials.gov, so these are shown separately rather than added to the count above. Trials with a site in Ireland are listed first.
| Study | Phase | Status | Sponsor | Countries |
|---|---|---|---|---|
|
A prospective, open-label, single-arm, multicenter pharmacokinetic study evaluating the placental transfer of dapirolizumab pegol to the infant(s) from pregnant study participants with active systemic lupus erythematosus who are administered dapirolizumab pegol
2025-524595-37-00 · Immune system processes
|
Phase 1 | Authorised | UCB Biopharma | Greece, Italy, Netherlands + 6 more |
Epinephrine across our data
Ireland · EU · USThe same active substance in our other registers, matched by its exact name. Each entry links to the register record it comes from.
Licensed in Ireland (HPRA)
3 single-substance products containing Epinephrine on the HPRA medicines list.
- Anapen 300 micrograms in 0.3 ml solution for injection in a pre-filled syringeBioprojet Pharma · PA22580/001/002 · Marketed
- Anapen 500 micrograms/0.3 ml solution for injection in a pre-filled syringeBioprojet Pharma · PA22580/001/003 · Marketed
- Anapen Junior 150 micrograms in 0.3 ml solution for injection in a pre- filled syringeBioprojet Pharma · PA22580/001/001 · Marketed
Supply shortages
- Epinephrine InjectionUS (FDA) · Resolved · updated 7 Nov 2025
Conditions studied with Epinephrine
27 conditionsAll 27 conditions
| Condition (as registered) | Trials |
|---|---|
| Advanced Solid Tumors | 2 |
| Anaphylaxis | 2 |
| Malignant Neoplasm | 1 |
| Epinephrine | 1 |
| Hypersensitivity, Immediate | 1 |
| Urticaria Chronic | 1 |
| Malignant Neoplam | 1 |
| Pulmonary Arterial Hypertension (PAH) | 1 |
| Chronic Thromboembolic Pulmonary Hypertension (CTEPH) | 1 |
| Hypertension, Pulmonary | 1 |
| Dentofacial Deformities | 1 |
| Analgesia | 1 |
| Vomiting, Postoperative | 1 |
| Nausea, Postoperative | 1 |
| Peri-intubation Hypotension | 1 |
| Hypersensitivity | 1 |
| Pediatric Out-of-Hospital Cardiac Arrest | 1 |
| Cardiac Arrest, Out-Of-Hospital | 1 |
| Sudden Cardiac Arrest | 1 |
| Ventricular Fibrillation | 1 |
| Ventricular Tachycardia-Pulseless | 1 |
| Cardiac Arrest Neonatal | 1 |
| Cardiac Anaesthesia | 1 |
| Cardiopulmonary Bypass | 1 |
| Intra-Prostatic Epinephrine Injection in Bipolar Transurethral Resection of Large Prostate | 1 |
| ST Segment Elevation Myocardial Infarction (STEMI) | 1 |
| No Reflow Phenomenon | 1 |
Sponsors
lead sponsor per trial| Lead sponsor | Trials |
|---|---|
| Merck Sharp & Dohme LLC | 2 |
| Hikma Pharmaceuticals USA Inc | 1 |
| ARS Pharmaceuticals, Inc | 1 |
| China National Center for Cardiovascular Diseases | 1 |
| Bezmialem Vakif University | 1 |
| Marmara University Pendik Training and Research Hospital | 1 |
| Dr. George Luciuk | 1 |
| London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 1 |
| Unity Health Toronto | 1 |
| University of Alberta | 1 |
| Mansoura University | 1 |
| Benha University | 1 |
| Ain Shams University | 1 |
By country register
A trial with sites in more than one country appears in each of those registers. CTIS does not publish a recruiting flag; its trials may also appear in the registers above.
Related compounds
Questions about Epinephrine trials
How many clinical trials are testing Epinephrine?
14 current trials in our Canada, USA, Egypt, Switzerland, Turkey, Germany and China registers name Epinephrine as a drug or biological intervention, as of the registry sync on 9 November 2026. Completed and withdrawn studies are not counted.
Are Epinephrine trials recruiting patients?
Yes. 10 of the 14 trials are recruiting: 4 with sites in Canada, 3 with sites in USA, 3 with sites in Egypt, 2 with sites in Switzerland, 1 with sites in Germany and 1 with sites in China. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.
Who sponsors Epinephrine clinical trials?
Merck Sharp & Dohme LLC (2), Hikma Pharmaceuticals USA Inc (1), ARS Pharmaceuticals, Inc (1) and China National Center for Cardiovascular Diseases (1), among 13 lead sponsors in total. The number in brackets is how many trials each organisation leads.
Is Epinephrine licensed in Ireland?
Yes. The HPRA medicines list includes 3 single-substance products containing Epinephrine, for example Anapen 300 micrograms in 0.3 ml solution for injection in a pre-filled syringe (Bioprojet Pharma). A licence does not mean a product is currently marketed or reimbursed; see each product's record.
Is there a Epinephrine shortage?
The registers we track list 1 entry for Epinephrine: US FDA: resolved. Shortages are product- and country-specific; check with a pharmacist.
Where does this information come from?
Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Epinephrine works or whether it is effective, and it is not medical advice.
How this page is built
Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Epinephrine works or whether it is effective. Each trial links to its own record so you can check it yourself.
- ClinicalTrials.gov (U.S. National Library of Medicine) ↗ Trial IDs, titles, intervention names and synonyms, phase, overall status, lead sponsor and conditions for every trial on this page
This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Epinephrine (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 9 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.