Assessment of Diastolic Function During the Transitional Period and Infancy Using Serial Echocardiography

Condition(s) studied

Study summary

The goal of this single-centre longitudinal observational study is to create reference values for diastolic function parameters in neonates born at 35 weeks' gestation or above, and to assess the influence of pre-defined antenatal, intrapartum, maternal, and neonatal factors on cardiac function.

The main question it aims to answer are:

* What are the normal reference ranges for parameters of diastolic cardiac function in neonates?
* How are these influenced by maternal, intrapartum and neonatal factors?
* Do the diastolic changes noted during the first two days of life persist into infancy?

Participants will have four echocardiographic assessments in total:

* Two during the first 48 hours of life (prior to discharge home)
* Two during infancy (as an outpatient)

Eligibility

Primary outcome measure(s)

• Reference values for diastolic function parameters in neonates — Day 1 and Day 2 of life
  Establish reference values for conventional and novel echocardiographic methods of assessing diastolic function in neonates and stratify them by different antenatal, intrapartum, maternal and neonatal factors to assess whether there is an association between these factors and cardiac function.
• Persistence of diastolic function changes into infancy — 6 - 9 months of life, 12 - 18 months of life
  Assess whether the diastolic function changes noted in the first few days persist over time.

Trial sites (1)

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