Ireland
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Priya Life Science Compound trial record
Compound · clinical trials

Monalizumab clinical trials

Also listed in trial records as IPH2201, HumZ270, MAb IPH2201
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 5 trials in our Italy, USA, France, Spain, Canada, South Korea, Belgium, Portugal, Taiwan, UK, Australia, Turkey, Germany, Poland, Brazil, Japan, Ireland, Netherlands, Switzerland, Austria and China registers that name Monalizumab as an intervention. Synced 10 Nov 2026
5Current trials
2Recruiting now
3Lead sponsors
21Country registers
At a glance

Monalizumab is named as an intervention in 5 current clinical trials in our Italy, USA, France, Spain, Canada, South Korea, Belgium, Portugal, Taiwan, UK, Australia, Turkey, Germany, Poland, Brazil, Japan, Ireland, Netherlands, Switzerland, Austria and China registers. 2 are recruiting patients now. The most common phase is Phase 2. The sponsor with the most trials is AstraZeneca (3). The most-studied condition is Non-small Cell Lung Cancer.

How Monalizumab works

All drug targets →
  • NKG2-A/NKG2-B type II integral membrane protein inhibitor Inhibitor
    Target: KLRC1 killer cell lectin like receptor C1
    ✓ In ChEMBL and the Guide to Pharmacology
Diseases it has been tested for in clinical trials, by furthest phase
  • Head and neck squamous cell carcinomaPhase 3
  • Non-small cell lung carcinomaPhase 3
  • COVID-19Phase 2
  • Acute myeloid leukemiaPhase 2
  • Breast cancerPhase 2
  • CancerPhase 2
  • Colorectal cancerPhase 2
  • Endometrial cancerPhase 2
  • Gastric cancerPhase 2
  • Myelodysplastic syndromePhase 2
20 diseases in all

Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL4297787, CC BY-SA 3.0. Targets checked against the IUPHAR/BPS Guide to PHARMACOLOGY (2026.3.1), ligand 8323, CC BY-SA 4.0. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.

Patient leaflets for Monalizumab

The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.

  • UK
    United Kingdom: Search MHRA Products
    Patient information leaflets and SmPCs for UK-licensed products.
  • US
    United States: Search DailyMed
    FDA-approved labels, including patient and medication guides.

Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.

Trials by status

  • Recruiting240%
  • Active, closed360%

Trials by phase

  • Phase 2240%
  • Phase 3240%
  • Phase 1/2120%
01

Clinical trials of Monalizumab

5 trials
StudyPhaseStatusLead sponsorRegisters
Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer
NCT05061550 · Non-small Cell Lung Cancer
Phase 2 Recruiting AstraZeneca Ireland, USA, France, Spain, Italy, Belgium, Portugal, Turkey, Canada, South Korea, Taiwan
Anti-NKG2A Monoclonal Antibody for AML or MDS Patients Undergoing Haploidentical Transplantation
NCT06892223 · ClinicalTrials.gov ↗ · Acute Myeloid Leukaemia, MDS (Myelodysplastic Syndrome), MPN (Myeloproliferative Neoplasms)
Phase 2 Recruiting Istituto Clinico Humanitas Italy
Assessment of Efficacy and Safety of Monalizumab Plus Cetuximab Compared to Placebo Plus Cetuximab in Recurrent or Metastatic Head and Neck Cancer
NCT04590963 · Squamous Cell Carcinoma of the Head and Neck
Phase 3 Active, closed AstraZeneca UK, USA, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Switzerland, Austria, Portugal, Canada, Brazil, Japan, South Korea, Taiwan, Australia
A Global Study to Assess the Effects of Durvalumab With Oleclumab or Durvalumab With Monalizumab Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer
NCT05221840 · Non-Small Cell Lung Cancer
Phase 3 Active, closed AstraZeneca UK, USA, China, Germany, France, Spain, Italy, Poland, Portugal, Turkey, Canada, Brazil, Japan, South Korea, Taiwan, Australia
A Study of Durvalumab (MEDI4736) and Monalizumab in Solid Tumors
NCT02671435 · Advanced Solid Tumors
Phase 1/2 Active, closed MedImmune LLC UK, USA, France, Spain, Italy, Belgium, Canada, South Korea, Australia

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Monalizumab

7 conditions
Non-small Cell Lung Cancer1Advanced Solid Tumors1Squamous Cell Carcinoma of the Head and Neck1Non-Small Cell Lung Cancer1Acute Myeloid Leukaemia1MDS (Myelodysplastic Syndrome)1MPN (Myeloproliferative Neoplasms)1
05

Related compounds

06

Questions about Monalizumab trials

How many clinical trials are testing Monalizumab?

5 current trials in our Italy, USA, France, Spain, Canada, South Korea, Belgium, Portugal, Taiwan, UK, Australia, Turkey, Germany, Poland, Brazil, Japan, Ireland, Netherlands, Switzerland, Austria and China registers name Monalizumab (also registered as IPH2201) as a drug or biological intervention, as of the registry sync on 10 November 2026. Completed and withdrawn studies are not counted.

Are Monalizumab trials recruiting patients?

Yes. 2 of the 5 trials are recruiting: 2 with sites in Italy, 1 with sites in USA, 1 with sites in France, 1 with sites in Spain, 1 with sites in Canada, 1 with sites in South Korea, 1 with sites in Belgium, 1 with sites in Portugal, 1 with sites in Taiwan, 1 with sites in Turkey and 1 with sites in Ireland. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Monalizumab clinical trials?

AstraZeneca (3), MedImmune LLC (1) and Istituto Clinico Humanitas (1). The number in brackets is how many trials each organisation leads.

Are there Monalizumab clinical trials in Ireland?

Yes. 1 trial in our Ireland register (ClinicalTrials.gov). Some may be the same study registered in both. See the Irish clinical trials register for sites and contacts.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Monalizumab works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Monalizumab works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Monalizumab (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 10 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.