Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors
NCT03067181 · ClinicalTrials.gov ↗ · Childhood Extracranial Germ Cell Tumor, Extragonadal Embryonal Carcinoma, Germ Cell Tumor
|
Phase 3 |
Recruiting |
Children's Oncology Group |
India, Canada, Mexico, Japan, Australia, Israel |
Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)
NCT03126916 · ClinicalTrials.gov ↗ · Ganglioneuroblastoma, Ganglioneuroblastoma, Nodular, Neuroblastoma
|
Phase 3 |
Recruiting |
Children's Oncology Group |
Canada, Mexico, Israel |
A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma
NCT04166409 · ClinicalTrials.gov ↗ · Low Grade Astrocytoma, Low Grade Glioma, Metastatic Low Grade Astrocytoma
|
Phase 3 |
Recruiting |
National Cancer Institute (NCI) |
Canada |
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
NCT04267848 · ClinicalTrials.gov ↗ · Lung Non-Small Cell Carcinoma, Lung Non-Small Cell Squamous Carcinoma, Lung Non-Squamous Non-Small Cell Carcinoma
|
Phase 3 |
Recruiting |
National Cancer Institute (NCI) |
Norway, Mexico, Israel |
Neoadjuvant Upper Tract Invasive Cancer Trial (NAUTICAL)
NCT04574960 · ClinicalTrials.gov ↗ · Bladder Cancer, Bladder Urothelial Carcinoma
|
Phase 3 |
Recruiting |
University Health Network, Toronto |
Canada |
Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer
NCT05624996 · ClinicalTrials.gov ↗ · Locally Advanced Lung Non-Small Cell Carcinoma, Stage IIB Lung Cancer AJCC v8, Stage III Lung Cancer AJCC v8
|
Phase 3 |
Recruiting |
NRG Oncology |
Canada, Mexico |
Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer
NCT05929768 · Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8
|
Phase 3 |
Recruiting |
SWOG Cancer Research Network |
Mexico, Israel |
Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma
NCT06172296 · ClinicalTrials.gov ↗ · Ganglioneuroblastoma, Nodular, Neuroblastoma
|
Phase 3 |
Recruiting |
National Cancer Institute (NCI) |
Canada, Mexico, Australia, Israel |
A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)
NCT06401330 · Stage I Mixed Cell Type Kidney Wilms Tumor, Stage II Mixed Cell Type Kidney Wilms Tumor, Stage III Mixed Cell Type Kidney Wilms Tumor
|
Phase 3 |
Recruiting |
Children's Oncology Group |
Canada, Australia, Israel |
Study of Treatment With Sacituzumab and Zimberelimab for Patients With Lung Cancer Confined to the Chest and Previously Operated on Who Were Not Disease-free.
NCT06431633 · ClinicalTrials.gov ↗ · Lung Diseases, Carcinoma, Non-Small-Cell Lung, Resectable Lung Non-Small Cell Carcinoma
|
Phase 3 |
Recruiting |
Fundación GECP |
Spain |
|
A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)
|
Phase 3 |
Recruiting |
Merck Sharp & Dohme LLC |
Ireland, UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Sweden, Poland, Turkey, Canada, Brazil, Japan, South Korea, Taiwan, Singapore, Australia, Israel |
|
A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)
|
Phase 3 |
Recruiting |
Merck Sharp & Dohme LLC |
UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Denmark, Poland, Czechia, Turkey, Canada, Brazil, Mexico, Japan, South Korea, Taiwan, Australia, Israel |
A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)
NCT06966700 · Breast Neoplasms, Triple Negative Breast Neoplasms, HR Low-Positive/HER2-Negative Breast Neoplasms
|
Phase 3 |
Recruiting |
Merck Sharp & Dohme LLC |
UK, USA, India, China, Germany, France, Spain, Italy, Belgium, Sweden, Poland, Czechia, Norway, Portugal, Turkey, Canada, Brazil, Japan, South Korea, Taiwan, Singapore, Australia, Israel |
|
DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer
|
Phase 3 |
Recruiting |
AstraZeneca |
UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Sweden, Denmark, Poland, Switzerland, Austria, Norway, Canada, Brazil, Japan, South Korea, Taiwan, Australia |
Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer
NCT07061977 · ClinicalTrials.gov ↗ · Locally Advanced Cervical Adenocarcinoma, Locally Advanced Cervical Adenosquamous Carcinoma, Locally Advanced Cervical Squamous Cell Carcinoma
|
Phase 3 |
Recruiting |
National Cancer Institute (NCI) |
Mexico, Israel |
|
A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)
|
Phase 3 |
Recruiting |
Merck Sharp & Dohme LLC |
UK, USA, China, France, Spain, Italy, Netherlands, Belgium, Poland, Switzerland, Austria, Turkey, Canada, Brazil, Mexico, Japan, South Korea, Taiwan, Australia, Israel |
Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer
NCT07198074 · ClinicalTrials.gov ↗ · Advanced Endometrial Carcinoma, Recurrent Endometrial Carcinoma
|
Phase 3 |
Recruiting |
National Cancer Institute (NCI) |
Mexico |
|
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)
|
Phase 3 |
Recruiting |
Merck Sharp & Dohme LLC |
Ireland, UK, USA, India, Germany, France, Spain, Italy, Belgium, Sweden, Denmark, Poland, Austria, Czechia, Canada, Brazil, Mexico, Japan, South Korea, Taiwan, Israel |
Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Advanced Head and Neck Cancer Who Cannot Receive Cisplatin
NCT07441681 · ClinicalTrials.gov ↗ · Locally Advanced Hypopharyngeal Squamous Cell Carcinoma, Locally Advanced Laryngeal Squamous Cell Carcinoma, Locally Advanced Oral Cavity Squamous Cell Carcinoma
|
Phase 3 |
Recruiting |
NRG Oncology |
Mexico |
Surgery With or Without Chemotherapy for Stage I NSCLC With Micropapillary Component ≥ 20%
NCT03351842 · ClinicalTrials.gov ↗ · Chemotherapy, Adjuvant, Lung Adenocarcinoma, Stage I, Treatment
|
Phase 2 |
Recruiting |
Shanghai Pulmonary Hospital, Shanghai, China |
China |
A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT
NCT04322318 · ClinicalTrials.gov ↗ · Anaplastic Kidney Wilms Tumor, Recurrent Kidney Wilms Tumor, Stage II Kidney Wilms Tumor
|
Phase 2 |
Recruiting |
Children's Oncology Group |
Canada, Mexico, Australia, Israel |
Folfox+Irinotecan+Chemort In Esophageal Cancer
NCT04656041 · ClinicalTrials.gov ↗ · Gastroesophageal Junction Adenocarcinoma, Esophagogastric Cancer
|
Phase 2 |
Recruiting |
Massachusetts General Hospital |
Israel |
Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma
NCT04671667 · ClinicalTrials.gov ↗ · Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Hypopharyngeal Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma
|
Phase 2 |
Recruiting |
National Cancer Institute (NCI) |
Mexico |
A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT
NCT04684368 · ClinicalTrials.gov ↗ · Central Nervous System Nongerminomatous Germ Cell Tumor, Choriocarcinoma, Embryonal Carcinoma
|
Phase 2 |
Recruiting |
Children's Oncology Group |
Canada, Australia, Israel |
Using ctDNA to Determine Therapies for Lung Cancer
NCT04966663 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer, Complete Surgical Resection, Circulating Tumor DNA
|
Phase 2 |
Recruiting |
University Health Network, Toronto |
Canada |
A Study of LP-300 With Carboplatin and Pemetrexed in Never Smokers With Advanced Lung Adenocarcinoma
NCT05456256 · Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung
|
Phase 2 |
Recruiting |
Lantern Pharma Inc |
USA, Japan, Taiwan |
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
NCT05489211 · Endometrial Cancer, Gastric Cancer, Metastatic Castration-resistant Prostate Cancer
|
Phase 2 |
Recruiting |
AstraZeneca |
UK, USA, China, Germany, France, Spain, Italy, Poland, Switzerland, Turkey, Canada, Japan, South Korea, Taiwan |
A Study to Give Treatment Inside the Eye to Treat Retinoblastoma
NCT05504291 · ClinicalTrials.gov ↗ · Bilateral Retinoblastoma, Childhood Intraocular Retinoblastoma, Group D Retinoblastoma
|
Phase 2 |
Recruiting |
Children's Oncology Group |
Canada, Australia |
Testing the Addition of BMS-986016 (Relatlimab) to the Usual Immunotherapy After Initial Treatment for Recurrent or Metastatic Nasopharyngeal Cancer
NCT06029270 · ClinicalTrials.gov ↗ · Metastatic Nasopharyngeal Carcinoma, Recurrent Nasopharyngeal Carcinoma, Stage IV Nasopharyngeal Carcinoma AJCC v8
|
Phase 2 |
Recruiting |
National Cancer Institute (NCI) |
Canada, Singapore, Australia |
Organoid-based Functional Precision Therapy for Advanced Breast Cancer
NCT06102824 · ClinicalTrials.gov ↗ · HER2-negative Breast Cancer, Advanced Breast Cancer
|
Phase 2 |
Recruiting |
Guangdong Provincial People's Hospital |
China |
A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma
NCT06368817 · ClinicalTrials.gov ↗ · Basal Ganglia Germinoma, Diabetes Insipidus, Germinoma
|
Phase 2 |
Recruiting |
Children's Oncology Group |
Canada, Australia, Israel |
Entrectinib as a Single Agent in Upfront Therapy for Children <3 Years of Age With NTRK1/2/3 or ROS1-FUSED CNS Tumors
NCT06528691 · ClinicalTrials.gov ↗ · High Grade Glioma, CNS Tumor
|
Phase 2 |
Recruiting |
St. Jude Children's Research Hospital |
Brazil |
|
A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer (NSCLC) (MK-3475-01G/KEYMAKER U01)
|
Phase 2 |
Recruiting |
Merck Sharp & Dohme LLC |
USA, Spain, Italy, Poland, Turkey, Taiwan, Israel |
|
Study of Patritumab Deruxtecan Plus Pembrolizumab With Other Anticancer Agents in Participants With High-Risk Early-Stage Triple-Negative or Hormone Receptor-Low Positive/HER-2 Negative Breast Cancer (MK-1022-010, HERTHENA-Breast-03)
|
Phase 2 |
Recruiting |
Merck Sharp & Dohme LLC |
USA, Spain, South Korea, Taiwan |
PALACE: Cemiplimab Trial According to ctDNA Levels
NCT06917573 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer Metastatic, Lung Diseases, Stage IV Non-small Cell Lung Cancer
|
Phase 2 |
Recruiting |
Fundación GECP |
Spain |
Neoadjuvant Treatment With Atezolizumab and Atezolizumab as Maintenance for the Treatment of Stage III Non Small-Cell Lung Cancer (NSCLC)
NCT07153445 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer, Stage IIIA Lung Cancer, Stage IIIB Lung Cancer
|
Phase 2 |
Recruiting |
Fundación GECP |
Spain |
Ivonescimab Alone And With Carboplatin/Pemetrexed For NSCLC
NCT07405190 · ClinicalTrials.gov ↗ · Lung Cancer (NSCLC), Lung Cancer Non-Small Cell Cancer (NSCLC), Lung Cancer (Non-Small Cell)
|
Phase 2 |
Recruiting |
Massachusetts General Hospital |
Israel |
|
European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors
|
Phase 1/2 |
Recruiting |
Gustave Roussy, Cancer Campus, Grand Paris |
France, Spain, Italy, Netherlands, Denmark |
|
KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)
|
Phase 1/2 |
Recruiting |
Merck Sharp & Dohme LLC |
USA, Spain, Italy, Poland, Canada, South Korea, Taiwan, Israel |
Phase 1/2 Clinical Trial of CP-506 (HAP) in Monotherapy or With Carboplatin or ICI
NCT04954599 · ClinicalTrials.gov ↗ · Unspecified Adult Solid Tumor, Protocol Specific
|
Phase 1/2 |
Recruiting |
Maastricht University Medical Center |
Spain, Netherlands, Belgium |
Phase I/IIa Study of AZD5335 as Monotherapy and Combination Therapy in Participants With Solid Tumors
NCT05797168 · Ovarian Cancer, Lung Adenocarcinoma, Endometrial Cancer
|
Phase 1/2 |
Recruiting |
AstraZeneca |
UK, USA, China, Germany, Spain, Turkey, Canada, Japan, South Korea, Taiwan, Australia, Israel |
Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
NCT06047379 · ClinicalTrials.gov ↗ · Diffuse Astrocytoma, IDH-Mutant, Glioblastoma, IDH-wildtype, Brain Metastases, Adult
|
Phase 1/2 |
Recruiting |
Neonc Technologies, Inc |
USA |
|
A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Head and Neck Cancer
|
Phase 1/2 |
Recruiting |
Janssen Research & Development, LLC |
UK, USA, China, Germany, France, Spain, Poland, Japan, South Korea, Taiwan |
A Randomised Trial of Chemotherapy Plus Surgery for Recurrent Non-Small Cell Lung Cancer
NCT02889666 · ClinicalTrials.gov ↗ · Recurrent Non-small Cell Lung Cancer
|
Phase 1 |
Recruiting |
Shanghai Jiao Tong University School of Medicine |
China, Japan |
Pathological Response After Neoadjuvant Treatment on NSCLC
NCT05167487 · ClinicalTrials.gov ↗ · Stage IIIA Non-small Cell Lung Cancer
|
Observational |
Recruiting |
Fundación GECP |
Spain |
|
Adjuvant Therapeutic Cancer Vaccine (AST-201, pUMVC3-hIGFBP-2) in Patients With Advanced Ovarian Cancer
|
Phase 2 |
Not yet open |
Aston Sci. Inc |
USA |
Carboplatin, Paclitaxel and Gemcitabine Hydrochloride With or Without Bevacizumab After Surgery in Treating Patients With Recurrent Ovarian, Epithelial, Primary Peritoneal, or Fallopian Tube Cancer
NCT00565851 · ClinicalTrials.gov ↗ · Clear Cell Adenocarcinoma, Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma
|
Phase 3 |
Active, closed |
National Cancer Institute (NCI) |
Mexico, Japan, South Korea |
Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
NCT00588770 · ClinicalTrials.gov ↗ · Neck Squamous Cell Carcinoma of Unknown Primary, Recurrent Hypopharyngeal Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma
|
Phase 3 |
Active, closed |
National Cancer Institute (NCI) |
Mexico, Israel |
Carboplatin and Paclitaxel or Oxaliplatin and Capecitabine With or Without Bevacizumab as First-Line Therapy in Treating Patients With Newly Diagnosed Stage II-IV or Recurrent Stage I Epithelial Ovarian or Fallopian Tube Cancer
NCT01081262 · ClinicalTrials.gov ↗ · Borderline Ovarian Mucinous Tumor, Ovarian Mucinous Cystadenocarcinoma, Recurrent Fallopian Tube Carcinoma
|
Phase 3 |
Active, closed |
National Cancer Institute (NCI) |
Mexico |
Paclitaxel and Carboplatin With or Without Bevacizumab in Treating Patients With Stage II, Stage III, or Stage IV Ovarian Epithelial Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer
NCT01167712 · ClinicalTrials.gov ↗ · Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma, Fallopian Tube Transitional Cell Carcinoma
|
Phase 3 |
Active, closed |
National Cancer Institute (NCI) |
Canada, Mexico, South Korea, Israel |
The Efficacy and Safety of the Postoperative Adjuvant Treatment in Patients With High-risk Stage I Endometrial Carcinoma
NCT01820858 · ClinicalTrials.gov ↗ · Endometrial Neoplasms
|
Phase 3 |
Active, closed |
Ding Ma |
China |
Response and Biology-Based Risk Factor-Guided Therapy in Treating Younger Patients With Non-high Risk Neuroblastoma
NCT02176967 · ClinicalTrials.gov ↗ · Ganglioneuroblastoma, Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma
|
Phase 3 |
Active, closed |
Children's Oncology Group |
Canada, Mexico, Australia, Israel |
Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors
NCT02375204 · Germ Cell Tumor, Teratoma, Choriocarcinoma
|
Phase 3 |
Active, closed |
Alliance for Clinical Trials in Oncology |
Ireland, Germany, France, Spain, Italy, Netherlands, Belgium, Denmark, Switzerland, Australia |
Platinum in Treating Patients With Residual Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy
NCT02445391 · ClinicalTrials.gov ↗ · Estrogen Receptor Negative, HER2/Neu Negative, Invasive Breast Carcinoma
|
Phase 3 |
Active, closed |
ECOG-ACRIN Cancer Research Group |
Mexico, Israel |
Testing the Use of A Single Drug (Olaparib) or the Combination of Two Drugs (Cediranib and Olaparib) Compared to the Usual Chemotherapy for Women With Platinum Sensitive Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
NCT02446600 · ClinicalTrials.gov ↗ · Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Transitional Cell Carcinoma, Fallopian Tube Undifferentiated Carcinoma
|
Phase 3 |
Active, closed |
National Cancer Institute (NCI) |
Canada, Mexico, Japan, South Korea |
Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel With or Without Carboplatin in Treating Patients With Triple-Negative Breast Cancer
NCT02488967 · ClinicalTrials.gov ↗ · Breast Adenocarcinoma, Estrogen Receptor Negative, HER2/Neu Negative
|
Phase 3 |
Active, closed |
NRG Oncology |
Norway, Canada, Israel, Egypt |
Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery
NCT03533582 · ClinicalTrials.gov ↗ · Childhood Hepatocellular Carcinoma, Childhood Malignant Liver Neoplasm, Fibrolamellar Carcinoma
|
Phase 3 |
Active, closed |
Children's Oncology Group |
Canada, Mexico, Australia, Israel |
Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer
NCT03793179 · ClinicalTrials.gov ↗ · Lung Non-Squamous Non-Small Cell Carcinoma, Stage IIIB Lung Cancer AJCC v8, Stage IIIC Lung Cancer AJCC v8
|
Phase 3 |
Active, closed |
National Cancer Institute (NCI) |
Canada, Mexico, Israel |
Testing the Addition of a New Immunotherapy Drug, Atezolizumab (MPDL3280A), to the Usual Chemoradiation (CRT) Therapy Treatment for Limited Stage Small Cell Lung Cancer (LS-SCLC)
NCT03811002 · ClinicalTrials.gov ↗ · Limited Stage Lung Small Cell Carcinoma, Stage I Lung Cancer AJCC v8, Stage II Lung Cancer AJCC v8
|
Phase 3 |
Active, closed |
National Cancer Institute (NCI) |
Norway, Mexico, Japan, Egypt |
A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma
NCT03871257 · ClinicalTrials.gov ↗ · Low Grade Glioma, Neurofibromatosis Type 1, Visual Pathway Glioma
|
Phase 3 |
Active, closed |
National Cancer Institute (NCI) |
Canada, Mexico |
Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Stage III-IV or Recurrent Endometrial Cancer
NCT03914612 · ClinicalTrials.gov ↗ · Endometrial Clear Cell Adenocarcinoma, Endometrial Dedifferentiated Carcinoma, Endometrial Endometrioid Adenocarcinoma
|
Phase 3 |
Active, closed |
National Cancer Institute (NCI) |
Canada, Mexico, Japan, South Korea, Israel, Egypt |
Testing the Addition of an Antibody to Standard Chemoradiation Followed by the Antibody for One Year to Standard Chemoradiation Followed by One Year of the Antibody in Patients With Unresectable Stage III Non-Small Cell Lung Cancer
NCT04092283 · ClinicalTrials.gov ↗ · Recurrent Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8
|
Phase 3 |
Active, closed |
National Cancer Institute (NCI) |
Mexico, Israel |
Letrozole With or Without Paclitaxel and Carboplatin in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
NCT04095364 · Low Grade Fallopian Tube Serous Adenocarcinoma, Ovarian Low Grade Serous Adenocarcinoma, Primary Peritoneal Low Grade Serous Adenocarcinoma
|
Phase 3 |
Active, closed |
NRG Oncology |
Ireland, Canada, Mexico, South Korea, Egypt |
Study of Pembrolizumab With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib in Stage III Non-Small Cell Lung Cancer (NSCLC) (MK-7339-012/KEYLYNK-012)
NCT04380636 · Lung Neoplasms, Carcinoma, Non-Small-Cell Lung
|
Phase 3 |
Active, closed |
Merck Sharp & Dohme LLC |
UK, USA, China, Germany, France, Spain, Italy, Poland, Czechia, Norway, Turkey, Canada, Mexico, Japan, South Korea |
Oregovomab Plus Chemo in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer Following Optimal Debulking Surgery
NCT04498117 · Carcinoma, Ovarian Epithelial, Ovarian Neoplasms, Ovarian Cancer
|
Phase 3 |
Active, closed |
CanariaBio Inc |
USA, India, Spain, Italy, Belgium, Czechia, Canada, Brazil, Mexico, South Korea, Taiwan |
New Adjuvant Trial of Chemotherapy vs Chemo-immunotherapy
NCT04564157 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer, Adjuvant Chemotherapy
|
Phase 3 |
Active, closed |
Fundación GECP |
Spain |
Sacituzumab Govitecan in Primary HER2-negative Breast Cancer
NCT04595565 · HER2-negative Breast Cancer, Triple Negative Breast Cancer
|
Phase 3 |
Active, closed |
GBG Forschungs GmbH |
Ireland, Germany, France, Spain, Belgium, Switzerland, Austria |
|
Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma (MK-3475-C93/KEYNOTE-C93/GOG-3064/ENGOT-en15)
|
Phase 3 |
Active, closed |
Merck Sharp & Dohme LLC |
Ireland, UK, USA, China, Germany, Spain, Italy, Netherlands, Belgium, Sweden, Denmark, Poland, Czechia, Norway, Turkey, Canada, Brazil, Japan, South Korea, Taiwan, Australia, Israel |
|
Pembrolizumab/Vibostolimab (MK-7684A) or Atezolizumab in Combination With Chemotherapy in First Line Treatment of Extensive-Stage Small Cell Lung Cancer (MK-7684A-008/KEYVIBE-008)
|
Phase 3 |
Active, closed |
Merck Sharp & Dohme LLC |
Ireland, UK, USA, China, Germany, France, Spain, Italy, Netherlands, Poland, Austria, Portugal, Turkey, Canada, Mexico, Japan, South Korea, Australia, Israel |
Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma
NCT05256225 · ClinicalTrials.gov ↗ · Endometrial Carcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Dedifferentiated Carcinoma
|
Phase 3 |
Active, closed |
National Cancer Institute (NCI) |
Mexico, South Korea |
|
MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma
|
Phase 3 |
Active, closed |
AstraZeneca |
UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Denmark, Poland, Switzerland, Norway, Turkey, Canada, Brazil, Japan, South Korea, Taiwan, Australia |
A Trial to Learn How Effective and Safe Odronextamab is Compared to Standard of Care for Adult Participants With Previously Treated Aggressive B-cell Non-Hodgkin Lymphoma
NCT06230224 · ClinicalTrials.gov ↗ · B-Cell Non-Hodgkin Lymphoma (B-NHL)
|
Phase 3 |
Active, closed |
Regeneron Pharmaceuticals |
Spain, Turkey, Brazil, South Korea, Taiwan, Singapore, Australia |
Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers
NCT05063552 · ClinicalTrials.gov ↗ · Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Metastatic Head and Neck Squamous Cell Carcinoma, Metastatic Hypopharyngeal Squamous Cell Carcinoma
|
Phase 2/3 |
Active, closed |
National Cancer Institute (NCI) |
Mexico |
|
A Trial to Learn How the Combination of Fianlimab With Cemiplimab and Chemotherapy Works Compared With Cemiplimab and Chemotherapy for Treating Adult Patients With Advanced Non-small Cell Lung Cancer
|
Phase 2/3 |
Active, closed |
Regeneron Pharmaceuticals |
USA, Turkey, Canada, Mexico, South Korea, Taiwan, Australia, Israel |
Paclitaxel, Carboplatin, and Bevacizumab or Paclitaxel, Carboplatin, and Temsirolimus or Ixabepilone, Carboplatin, and Bevacizumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer
NCT00977574 · ClinicalTrials.gov ↗ · Endometrial Adenocarcinoma, Endometrial Adenosquamous Carcinoma, Endometrial Clear Cell Adenocarcinoma
|
Phase 2 |
Active, closed |
National Cancer Institute (NCI) |
Mexico |
Transoral Surgery Followed By Low-Dose or Standard-Dose Radiation Therapy With or Without Chemotherapy in Treating Patients With HPV Positive Stage III-IVA Oropharyngeal Cancer
NCT01898494 · ClinicalTrials.gov ↗ · Human Papilloma Virus Infection, Stage III Squamous Cell Carcinoma of the Oropharynx, Stage IVA Squamous Cell Carcinoma of the Oropharynx
|
Phase 2 |
Active, closed |
ECOG-ACRIN Cancer Research Group |
Mexico |
Neoadjuvant Nivolumab, or Nivolumab in Combination With Ipilimumab, in Resectable NSCLC
NCT02259621 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer
|
Phase 2 |
Active, closed |
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins |
Canada |
Cisplatin and Etoposide Versus Temozolomide and Capecitabine in Patients With Advanced Poorly Differentiated (G3) Non-Small Cell Gastrointestinal Neuroendocrine Carcinomas
NCT02595424 · ClinicalTrials.gov ↗ · Gastric Neuroendocrine Carcinoma, Intestinal Neuroendocrine Carcinoma, Pancreatic Neuroendocrine Carcinoma
|
Phase 2 |
Active, closed |
ECOG-ACRIN Cancer Research Group |
Mexico, Israel |
M6620 and Carboplatin With or Without Docetaxel in Treating Patients With Metastatic Castration-Resistant Prostate Cancer
NCT03517969 · ClinicalTrials.gov ↗ · Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma, Stage IV Prostate Cancer AJCC v8
|
Phase 2 |
Active, closed |
National Cancer Institute (NCI) |
Israel |
|
9-ING-41 in Patients With Advanced Cancers
|
Phase 2 |
Active, closed |
Actuate Therapeutics Inc |
USA, France, Spain, Netherlands, Belgium, Portugal, Canada |
NADIM II: Neo-Adjuvant Immunotherapy
NCT03838159 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer
|
Phase 2 |
Active, closed |
Fundación GECP |
Spain |
Nivolumab and Ipilimumab Plus Chemotherapy for Patients With Stage IV Lung Cancer With Brain Metastases
NCT05012254 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer, Brain Metastases, Adult, Lung Cancer
|
Phase 2 |
Active, closed |
Fundación GECP |
Spain |
|
Study of Sacituzumab Govitecan Combinations in First-line Treatment of Participants With Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC)
|
Phase 2 |
Active, closed |
Gilead Sciences |
UK, USA, Germany, France, Spain, Italy, Canada, South Korea, Taiwan, Australia |
Testing the Addition of an Anti-Cancer Drug, TRC102, to the Usual Chemotherapy Treatment (Pemetrexed, Cisplatin or Carboplatin) During Radiation Therapy for Stage III Non-Squamous Non-Small Cell Lung Cancer
NCT05198830 · ClinicalTrials.gov ↗ · Lung Adenocarcinoma, Lung Large Cell Carcinoma, Lung Non-Squamous Non-Small Cell Carcinoma
|
Phase 2 |
Active, closed |
National Cancer Institute (NCI) |
Israel |
Oregovomab Plus Chemotherapy in Neo-adjuvant Setting in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer
NCT05605535 · Ovarian Neoplasm Epithelial, Ovarian Cancer, Fallopian Tube Neoplasms
|
Phase 2 |
Active, closed |
CanariaBio Inc |
India |
DUMAS: Neo-Adjuvant Immunotherapy for Pancoast Tumors
NCT05684276 · ClinicalTrials.gov ↗ · NSCLC, Pancoast Tumor
|
Phase 2 |
Active, closed |
Fundación GECP |
Spain |
|
A Trial to Learn if the Combination of Fianlimab, Cemiplimab, and Chemotherapy is Safe and Works Better Than the Combination of Cemiplimab and Chemotherapy in Adult Patients With Non-Small Cell Lung Cancer That Can be Treated With Surgery
|
Phase 2 |
Active, closed |
Regeneron Pharmaceuticals |
USA, Germany, France, Spain, Italy, Turkey, South Korea, Taiwan, Australia |
|
Pembrolizumab (MK-3475) Plus Investigational Agents in Resectable Non-small Cell Lung Cancer (NSCLC) (MK-3475-01E/KEYMAKER-U01)
|
Phase 2 |
Active, closed |
Merck Sharp & Dohme LLC |
USA, Spain, Italy, Poland, Turkey |
Evaluation of Dosing Procedures of Chemotherapy Treatment (Carboplatin) With the Contrast Agent Iohexol
NCT03997370 · ClinicalTrials.gov ↗ · Malignant Solid Neoplasm
|
Phase 1 |
Active, closed |
NRG Oncology |
Israel |
Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)
NCT02194738 · ClinicalTrials.gov ↗ · Stage IB Lung Non-Small Cell Carcinoma AJCC v7, Stage II Lung Non-Small Cell Cancer AJCC v7, Stage IIA Lung Cancer AJCC v8
|
Not applicable |
Active, closed |
National Cancer Institute (NCI) |
Norway, Mexico, Israel |