Ireland
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Priya Life Science Compound trial record
Compound · clinical trials

Sigvotatug vedotin clinical trials

Also listed in trial records as SGN-B6A, PF-08046047
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 4 trials in our USA, France, Spain, Taiwan, UK, Switzerland, South Korea, Israel, China, Germany, Italy, Japan, Netherlands, Belgium, Poland, Austria, Czechia, Canada, Brazil, Australia, Norway, India, Turkey and Mexico registers that name Sigvotatug vedotin as an intervention. Synced 9 Nov 2026
4Current trials
3Recruiting now
2Lead sponsors
24Country registers
At a glance

Sigvotatug vedotin is named as an intervention in 4 current clinical trials in our USA, France, Spain, Taiwan, UK, Switzerland, South Korea, Israel, China, Germany, Italy, Japan, Netherlands, Belgium, Poland, Austria, Czechia, Canada, Brazil, Australia, Norway, India, Turkey and Mexico registers. 3 are recruiting patients now. The most common phase is Phase 3. The sponsor with the most trials is Seagen, a wholly owned subsidiary of Pfizer (2). The most-studied condition is Carcinoma, Non-Small Cell Lung.

How Sigvotatug vedotin works

All drug targets →
  • Integrin beta-6 binding agent Binding agent
    Target: ITGB6 integrin subunit beta 6
    ChEMBL only
Diseases it has been tested for in clinical trials, by furthest phase
  • Non-small cell lung carcinomaPhase 3

Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL5314879, CC BY-SA 3.0. The Guide to Pharmacology has no record of this medicine, so its targets rest on ChEMBL alone. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.

Patient leaflets for Sigvotatug vedotin

The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.

  • UK
    United Kingdom: Search MHRA Products
    Patient information leaflets and SmPCs for UK-licensed products.
  • US
    United States: Search DailyMed
    FDA-approved labels, including patient and medication guides.

Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.

Trials by status

  • Recruiting375%
  • Active, closed125%

Trials by phase

  • Phase 3250%
  • Phase 1125%
  • Phase 1/2125%
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Clinical trials of Sigvotatug vedotin

4 trials
StudyPhaseStatusLead sponsorRegisters
This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.
NCT06758401 · Non-Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung, Carcinoma, Non-Small-Cell Lung (NSCLC)
Phase 3 Recruiting Pfizer UK, USA, India, China, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Switzerland, Austria, Czechia, Turkey, Canada, Brazil, Mexico, Japan, South Korea, Taiwan, Australia, Israel
Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers
NCT07227298 · Advanced/Metastatic Non-Small Cell Lung Cancer, Carcinoma, Non-Small Cell Lung, Non-Small Cell Lung Cancer
Phase 1/2 Recruiting Pfizer USA, China, Germany, France, Spain, Italy, Japan, Taiwan
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
NCT04389632 · Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck, HER2 Negative Breast Neoplasms
Phase 1 Recruiting Seagen, a wholly owned subsidiary of Pfizer UK, USA, France, Spain, Switzerland, South Korea, Taiwan, Israel
A Study of SGN-B6A Versus Docetaxel in Previously Treated Non-small Cell Lung Cancer
NCT06012435 · Carcinoma, Non-Small-Cell Lung
Phase 3 Active, closed Seagen, a wholly owned subsidiary of Pfizer UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Switzerland, Austria, Czechia, Norway, Canada, Brazil, Japan, South Korea, Taiwan, Australia, Israel

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Sigvotatug vedotin

8 conditions
Carcinoma, Non-Small Cell Lung2Carcinoma, Non-Small-Cell Lung2Non-Small Cell Lung Cancer2Squamous Cell Carcinoma of Head and Neck1HER2 Negative Breast Neoplasms1Esophageal Squamous Cell Carcinoma1Carcinoma, Non-Small-Cell Lung (NSCLC)1Advanced/Metastatic Non-Small Cell Lung Cancer1
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Related compounds

06

Questions about Sigvotatug vedotin trials

How many clinical trials are testing Sigvotatug vedotin?

4 current trials in our USA, France, Spain, Taiwan, UK, Switzerland, South Korea, Israel, China, Germany, Italy, Japan, Netherlands, Belgium, Poland, Austria, Czechia, Canada, Brazil, Australia, Norway, India, Turkey and Mexico registers name Sigvotatug vedotin (also registered as SGN-B6A) as a drug or biological intervention, as of the registry sync on 9 November 2026. Completed and withdrawn studies are not counted.

Are Sigvotatug vedotin trials recruiting patients?

Yes. 3 of the 4 trials are recruiting: 3 with sites in USA, 3 with sites in France, 3 with sites in Spain, 3 with sites in Taiwan, 2 with sites in UK, 2 with sites in Switzerland, 2 with sites in South Korea, 2 with sites in Israel, 2 with sites in China, 2 with sites in Germany, 2 with sites in Italy, 2 with sites in Japan, 1 with sites in Netherlands, 1 with sites in Belgium, 1 with sites in Poland, 1 with sites in Austria, 1 with sites in Czechia, 1 with sites in Canada, 1 with sites in Brazil, 1 with sites in Australia, 1 with sites in India, 1 with sites in Turkey and 1 with sites in Mexico. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Sigvotatug vedotin clinical trials?

Seagen, a wholly owned subsidiary of Pfizer (2) and Pfizer (2). The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Sigvotatug vedotin works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Sigvotatug vedotin works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Sigvotatug vedotin (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 9 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.