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Compound · clinical trials

PF-08634404

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 10 trials in our USA, China and India registers that name PF-08634404 as an intervention. Synced 24 Sep 2026
10Trials tracked
10Recruiting now
1Lead sponsor
3Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards

PF-08634404 is named as a drug or biological intervention in 10 clinical trials in our USA, China and India trial registers, 10 of which are recruiting. The lead sponsor is Pfizer. Registered phases: Phase 1/2, Phase 2, Phase 2/3 and Phase 3. Conditions studied include Lung Neoplasms; Non-Small Cell Lung Cancer; Carcinoma.

01

Clinical trials of PF-08634404

10 trials
NCT IDStudyPhaseStatusLead sponsorRegister
NCT07222566 Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (ClinicalTrials.gov ↗)
Advanced Non-Small Cell Lung Cancer, Non-Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung
Phase 3 Recruiting Pfizer USA, India, China
NCT07222800 Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer (ClinicalTrials.gov ↗)
Intestinal Neoplasms, Gastrointestinal Neoplasms, Digestive System Neoplasms
Phase 3 Recruiting Pfizer USA, China
NCT07226999 Symbiotic-Lung-04: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Extensive-Stage Small Cell Lung Cancer (ClinicalTrials.gov ↗)
Small Cell Lung Cancer (SCLC)
Phase 2/3 Recruiting Pfizer USA, China
NCT07392892 Symbiotic-GI-16: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer (ClinicalTrials.gov ↗)
Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction , or Esophageal Adenocarcinoma, Metastatic Gastric Cancer, Gastroesophageal Junction Cancer
Phase 2/3 Recruiting Pfizer USA, China
NCT07476287 Symbiotic-Lung-14: A Study to Learn About the Study Medicine Called PF08634404 in Combination With Chemotherapy in Adult Participants With Transformed Small Cell Lung Cancer (ClinicalTrials.gov ↗)
Small Cell Lung Cancer, Small Cell Lung Cancer ( SCLC ), Transformed Small Cell Lung Cancer
Phase 2 Recruiting Pfizer USA, China
NCT07489066 Symbiotic-Lung-10: A Study to Learn About PF-08634404 Alone or in Combination in Early-stage or Locally Advanced NSCLC
Carcinoma, Non-Small-Cell Lung, Lung Cancer (NSCLC)
Phase 2 Recruiting Pfizer USA, China
NCT07227012 Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body. (ClinicalTrials.gov ↗)
Carcinoma, Hepatocellular, Hepatocellular Cancer, Hepatocellular Carcinoma
Phase 1/2 Recruiting Pfizer USA
NCT07227298 Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers (ClinicalTrials.gov ↗)
Advanced/Metastatic Non-Small Cell Lung Cancer, Carcinoma, Non-Small Cell Lung, Non-Small Cell Lung Cancer
Phase 1/2 Recruiting Pfizer USA, China
NCT07227415 Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer (ClinicalTrials.gov ↗)
Carcinoma, Renal Cell, Advanced Renal Cell Carcinoma, Renal Cancer
Phase 1/2 Recruiting Pfizer USA, China
NCT07421700 Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer (ClinicalTrials.gov ↗)
Urothelial Cancer, Advanced/Metastatic Urothelial Cancer, Urothelial Carcinoma
Phase 1/2 Recruiting Pfizer USA, China

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied

33 conditions
Condition (as registered)Trials
Lung Neoplasms2
Non-Small Cell Lung Cancer2
Carcinoma1
Non-Small-Cell Lung1
Lung Cancer (NSCLC)1
Small Cell Lung Cancer (SCLC)1
Small Cell Lung Cancer1
Small Cell Lung Cancer ( SCLC )1
Transformed Small Cell Lung Cancer1
Intestinal Neoplasms1
Gastrointestinal Neoplasms1
Digestive System Neoplasms1
Neoplasms by Site1
Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction , or Esophageal Adenocarcinoma1
Metastatic Gastric Cancer1
Gastroesophageal Junction Cancer1
Esophageal Adenocarcinoma1
Urothelial Cancer1
Advanced/Metastatic Urothelial Cancer1
Urothelial Carcinoma1
Advanced/Metastatic Non-Small Cell Lung Cancer1
Carcinoma, Non-Small Cell Lung1
Advanced Non-Small Cell Lung Cancer1
Carcinoma, Non-Small-Cell Lung1
Carcinoma, Non-Small-Cell Lung (NSCLC)1
Carcinoma, Hepatocellular1
Hepatocellular Cancer1
Hepatocellular Carcinoma1
Unresectable Hepatocellular Carcinoma1
Carcinoma, Renal Cell1
Advanced Renal Cell Carcinoma1
Renal Cancer1
Renal Neoplasm1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Pfizer10
04

Trials by country register

A trial with sites in more than one country appears in each of those registers.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how PF-08634404 works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists PF-08634404 (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 24 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.