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Compound · clinical trials

VNZ/TEZ/D-IVA clinical trials

Also listed in trial records as VX-121/TEZ/D-IVA, VX-121/VX-661/VX-561, VX-121/VX-661/CTP-656, Vanzacaftor/tezacaftor/deutivacaftor
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 3 trials in our UK, USA, Germany, France, Netherlands, Sweden, Switzerland, Canada, Australia, Ireland, Spain, Italy, Belgium, Denmark, Poland, Austria, Czechia, Norway, Portugal and Israel registers that name VNZ/TEZ/D-IVA as an intervention. Synced 28 Sep 2026
3Current trials
0Recruiting now
1Lead sponsor
20Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

VNZ/TEZ/D-IVA is named as an intervention in 3 current clinical trials in our UK, USA, Germany, France, Netherlands, Sweden, Switzerland, Canada, Australia, Ireland, Spain, Italy, Belgium, Denmark, Poland, Austria, Czechia, Norway, Portugal and Israel registers. None are recruiting at the moment. All registered phases are Phase 3. The lead sponsor is Vertex Pharmaceuticals Incorporated. The most-studied condition is Cystic Fibrosis.

Trials by status

  • Active, closed267%
  • By invitation133%

Trials by phase

  • Phase 33100%
01

Clinical trials of VNZ/TEZ/D-IVA

3 trials
StudyPhaseStatusLead sponsorRegisters
Evaluation of Long-Term Safety and Efficacy of Vanzacaftor/Tezacaftor/Deutivacaftor in Cystic Fibrosis Participants 1 Year of Age and Older
NCT05844449 · ClinicalTrials.gov ↗ · Cystic Fibrosis
Phase 3 By invitation Vertex Pharmaceuticals Incorporated UK, USA, Germany, France, Netherlands, Sweden, Switzerland, Canada, Australia
Evaluation of VX-121/Tezacaftor/Deutivacaftor in Cystic Fibrosis (CF) Participants 1 Through 11 Years of Age
NCT05422222 · ClinicalTrials.gov ↗ · Cystic Fibrosis
Phase 3 Active, closed Vertex Pharmaceuticals Incorporated UK, USA, Germany, France, Netherlands, Sweden, Switzerland, Canada, Australia
A Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy
NCT05444257 · Cystic Fibrosis
Phase 3 Active, closed Vertex Pharmaceuticals Incorporated Ireland, UK, USA, Germany, France, Spain, Italy, Netherlands, Belgium, Sweden, Denmark, Poland, Switzerland, Austria, Czechia, Norway, Portugal, Canada, Australia, Israel

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with VNZ/TEZ/D-IVA

1 condition
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Vertex Pharmaceuticals Incorporated3
04

By country register

RegisterTrialsRecruiting
Clinical trials in UK30
Clinical trials in USA30
Clinical trials in Germany30
Clinical trials in France30
Clinical trials in Netherlands30
Clinical trials in Sweden30
Clinical trials in Switzerland30
Clinical trials in Canada30
Clinical trials in Australia30
Clinical trials in Ireland10
Clinical trials in Spain10
Clinical trials in Italy10
Clinical trials in Belgium10
Clinical trials in Denmark10
Clinical trials in Poland10
Clinical trials in Austria10
Clinical trials in Czechia10
Clinical trials in Norway10
Clinical trials in Portugal10
Clinical trials in Israel10

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about VNZ/TEZ/D-IVA trials

How many clinical trials are testing VNZ/TEZ/D-IVA?

3 current trials in our UK, USA, Germany, France, Netherlands, Sweden, Switzerland, Canada, Australia, Ireland, Spain, Italy, Belgium, Denmark, Poland, Austria, Czechia, Norway, Portugal and Israel registers name VNZ/TEZ/D-IVA (also registered as VX-121/TEZ/D-IVA) as a drug or biological intervention, as of the registry sync on 28 September 2026. Completed and withdrawn studies are not counted.

Are VNZ/TEZ/D-IVA trials recruiting patients?

Not at the moment. None of the 3 trials in our registers is recruiting; they are active but closed to enrolment, not yet open, or enrolling by invitation. Only the study team can confirm whether a patient is eligible.

Who sponsors VNZ/TEZ/D-IVA clinical trials?

The lead sponsor is Vertex Pharmaceuticals Incorporated. The number in brackets is how many trials each organisation leads.

Are there VNZ/TEZ/D-IVA clinical trials in Ireland?

Yes. 1 trial in our Ireland register (ClinicalTrials.gov). Some may be the same study registered in both. See the Irish clinical trials register for sites and contacts.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how VNZ/TEZ/D-IVA works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how VNZ/TEZ/D-IVA works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists VNZ/TEZ/D-IVA (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 28 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.