A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
Condition(s) studied
Investigational drug(s) / intervention(s)
Sonrotoclax: Administered orally
Obinutuzumab: Administered intravenously
Rituximab: Administered intravenously
Venetoclax: Administered Orally
Study summary
The goal of this study is to compare how well sonrotoclax plus obinutuzumab works versus venetoclax plus rituximab in treating adults with relapsed and/or refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The study will also compare how well sonrotoclax plus rituximab works versus venetoclax plus rituxumab in treating adults with R/R CLL/SLL. The safety of these treatments will also be assessed.
Eligibility
Primary outcome measure(s)
- Progression-Free Survival (PFS) as assessed by Blinded Independent Review Committee (BIRC) for Arm A versus Arm D — Up to approximately 51 months
PFS is defined as the time from randomization to the date of progression or death, whichever occurs first.
Trial sites (195)
| Facility | City | Region | Status |
|---|---|---|---|
| Uci Health Laguna Hills | Laguna Hills | California | Recruiting |
| Chao Family Comprehensive Cancer Center | Orange | California | Recruiting |
| Stanford Cancer Institute | Palo Alto | California | Recruiting |
| Scripps Prebys Cancer Center | San Diego | California | Recruiting |
| Rocky Mountain Cancer Centers (Williams) Usor | Aurora | Colorado | Recruiting |
| Yale University Yale Cancer Center | New Haven | Connecticut | Recruiting |
| Eastern Connecticut Hematology and Oncology | Norwich | Connecticut | Recruiting |
| Cleveland Clinic Florida | Weston | Florida | Recruiting |
| Northwestern University | Chicago | Illinois | Recruiting |
| Illinois Cancer Specialists (Niles) Usor | Niles | Illinois | Recruiting |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | Recruiting |
| Mission Cancer and Blood | Waukee | Iowa | Recruiting |
| University of Louisville, Brown Cancer Center | Louisville | Kentucky | Recruiting |
| Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | Recruiting |
| The University of Maryland Greenebaum Comprehensive Cancer Center | Baltimore | Maryland | Recruiting |
| Beth Israel Deaconess Medical Center (Bidmc) | Boston | Massachusetts | Recruiting |
| Dana Farber Cancer Institute | Boston | Massachusetts | Recruiting |
| The Cancer and Hematology Centers | Grand Rapids | Michigan | Recruiting |
| Mayo Clinic Rochester | Rochester | Minnesota | Recruiting |
| University of Nebraska Medical Center | Omaha | Nebraska | Recruiting |
| Sidney Kimmel Comprehensive Cancer Center Washington Twp | Sewell | New Jersey | Recruiting |
| Christus St Vincent Regional Cancer Center | Santa Fe | New Mexico | Recruiting |
| Memorial Sloan Kettering Cancer Center Mskcc | New York | New York | Recruiting |
| Optum Medical Care, Pc | Westbury | New York | Recruiting |
| University of North Carolina At Chapel Hill | Chapel Hill | North Carolina | Recruiting |
| Levine Cancer Center | Charlotte | North Carolina | Recruiting |
| Atrium Health Wake Forest Baptist | Winston-Salem | North Carolina | Recruiting |
| Oncology Hematology Care Clinical Trials, Llc | Cincinnati | Ohio | Recruiting |
| Oncology Associates of Oregon Willamette Valley Cancer Center | Eugene | Oregon | Recruiting |
| Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | Recruiting |
| Thomas Jefferson University | Philadelphia | Pennsylvania | Recruiting |
| Upmc Hillman Cancer Center(Univ of Pittsburgh) | Pittsburgh | Pennsylvania | Recruiting |
| Tennessee Oncology Greco Hainsworth Centers For Research Chattanooga | Chattanooga | Tennessee | Recruiting |
| Tennessee Oncology | Nashville | Tennessee | Recruiting |
| Texas Oncology Baylor Charles A Sammons Cancer Center | Dallas | Texas | Recruiting |
| Texas Oncology San Antonio Medical Center Usor | San Antonio | Texas | Recruiting |
| Texas Oncology Tyler | Tyler | Texas | Recruiting |
| Swedish Medical Center Swedish Cancer Institute First Hill Campus | Seattle | Washington | Recruiting |
| Northwest Cancer Specialist, Pc(Us Oncology Research) | Vancouver | Washington | Recruiting |
| Hospital Aleman | Caba | Argentina | Recruiting |
+ 155 more sites — see the full list on the official registry below.
More BeOne Medicines trials in Ireland
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06943872 on ClinicalTrials.gov ↗ ← All trials in Ireland