Ireland
--:--IST
Priya Life Science Compound trial record
Compound · clinical trials

KarX-EC clinical trials

Also listed in trial records as BMS-986519, Xanomeline Enteric, Xanomeline MR, KarX-MR, Xanomeline, KarX
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 11 trials in our USA, Poland, Japan, France, Spain, Australia, Canada, UK, Germany, India, Italy, Brazil, Portugal, Czechia, South Korea, Netherlands, Israel, China, Mexico and Taiwan registers that name KarX-EC as an intervention. Synced 9 Nov 2026
11Current trials
9Recruiting now
2Lead sponsors
20Country registers
At a glance

KarX-EC is named as an intervention in 11 current clinical trials in our USA, Poland, Japan, France, Spain, Australia, Canada, UK, Germany, India, Italy, Brazil, Portugal, Czechia, South Korea, Netherlands, Israel, China, Mexico and Taiwan registers. 9 are recruiting patients now. The most common phase is Phase 3. The sponsor with the most trials is Bristol-Myers Squibb (10). The most-studied condition is Alzheimer's Disease.

Patient leaflets for KarX-EC

The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.

  • UK
    United Kingdom: Search MHRA Products
    Patient information leaflets and SmPCs for UK-licensed products.
  • US
    United States: Search DailyMed
    FDA-approved labels, including patient and medication guides.

Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.

Trials by status

  • Recruiting982%
  • Not yet open218%

Trials by phase

  • Phase 31091%
  • Phase 119%
01

Clinical trials of KarX-EC

11 trials
StudyPhaseStatusLead sponsorRegisters
A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
NCT06937229 · Alzheimer Disease, Agitation
Phase 3 Recruiting Bristol-Myers Squibb UK, USA, India, China, Germany, France, Spain, Italy, Poland, Czechia, Portugal, Canada, Brazil, Mexico, Japan, South Korea, Taiwan, Israel
A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5)
NCT06947941 · Alzheimer Disease, Psychosis
Phase 3 Recruiting Bristol-Myers Squibb UK, USA, Canada, Japan, Australia
A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder
NCT06951698 · Bipolar-I Disorder With Mania or Mania With Mixed Features
Phase 3 Recruiting Bristol-Myers Squibb USA, Poland, Japan, Australia
A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)
NCT06976203 · Alzheimer's Disease
Phase 3 Recruiting Bristol-Myers Squibb UK, USA, Germany, France, Spain, Italy, Netherlands, Poland, Portugal, Brazil, Japan, Australia
A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease
NCT06976216 · Alzheimer's Disease
Phase 3 Recruiting Bristol-Myers Squibb USA, India, Germany, France, Spain, Italy, Netherlands, Poland, Czechia, Canada, Brazil, South Korea, Australia
A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)
NCT07011732 · Alzheimer Disease
Phase 3 Recruiting Bristol-Myers Squibb USA, India, China, Spain, Portugal, Canada, Brazil, Mexico, Japan, Taiwan
A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease
NCT07011745 · Alzheimer's Disease
Phase 3 Recruiting Bristol-Myers Squibb UK, USA, Germany, France, Italy, Poland, Czechia, South Korea, Israel
A Study to Evaluate the Long-term Safety and Tolerability of Xanomeline and Trospium Chloride for the Treatment of Psychiatric Disorders in Children and Adolescents
NCT07424404 · Schizophrenia, Autism-Related Irritability
Phase 3 Recruiting Karuna Therapeutics, Inc., a Bristol Myers Squibb company USA, India, France, Spain, Poland, Canada, Japan, Australia
A Study to Evaluate Novel KarX and KarT Prototypes Versus the KarXT and KarX-EC Reference Following Single Doses, Explore the Effect of Food After Multiple Doses of Selected Prototypes, and Evaluate Alternative Formulations of KarX and KarXT Following Single and Multiple Ascending Doses
NCT07063342 · Healthy Volunteers
Phase 1 Recruiting Bristol-Myers Squibb UK
A Study of KarXT + KarX-EC for Treatment of Irritability in Children and Adolescents With Autism
NCT07284745 · Irritability Associated With Autism Spectrum Disorder
Phase 3 Not yet open Bristol-Myers Squibb USA, Canada, Australia
A Study of KarXT + KarX-EC for Treatment of Irritability in Children and Adolescents With Autism Spectrum Disorder
NCT07285798 · Irritability Associated With Autism Spectrum Disorder
Phase 3 Not yet open Bristol-Myers Squibb USA, India, Germany, France, Spain, Poland, Japan

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with KarX-EC

9 conditions
Alzheimer's Disease3Alzheimer Disease3Irritability Associated With Autism Spectrum Disorder2Agitation1Psychosis1Healthy Volunteers1Schizophrenia1Autism-Related Irritability1Bipolar-I Disorder With Mania or Mania With Mixed Features1
05

Related compounds

06

Questions about KarX-EC trials

How many clinical trials are testing KarX-EC?

11 current trials in our USA, Poland, Japan, France, Spain, Australia, Canada, UK, Germany, India, Italy, Brazil, Portugal, Czechia, South Korea, Netherlands, Israel, China, Mexico and Taiwan registers name KarX-EC (also registered as BMS-986519) as a drug or biological intervention, as of the registry sync on 9 November 2026. Completed and withdrawn studies are not counted.

Are KarX-EC trials recruiting patients?

Yes. 9 of the 11 trials are recruiting: 8 with sites in USA, 6 with sites in Poland, 6 with sites in Japan, 5 with sites in France, 5 with sites in Spain, 5 with sites in Australia, 5 with sites in Canada, 5 with sites in UK, 4 with sites in Germany, 4 with sites in India, 4 with sites in Italy, 4 with sites in Brazil, 3 with sites in Portugal, 3 with sites in Czechia, 3 with sites in South Korea, 2 with sites in Netherlands, 2 with sites in Israel, 2 with sites in China, 2 with sites in Mexico and 2 with sites in Taiwan. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors KarX-EC clinical trials?

Bristol-Myers Squibb (10) and Karuna Therapeutics, Inc., a Bristol Myers Squibb company (1). The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how KarX-EC works or whether it is effective, and it is not medical advice.

Approvals, shortages and trials, every Friday

One email a week with new EMA and FDA approvals, EU and US medicine shortages, how many trials are recruiting in Ireland, and the week's Irish pharma news.

Free. Unsubscribe from any email with one click. See our privacy policy.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how KarX-EC works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists KarX-EC (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 9 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.