A Study of Baricitinib (LY3009104) in Participants From 2 Years to Less Than 18 Years Old With Active JIA-Associated Uveitis or Chronic Anterior Antinuclear Antibody-Positive Uveitis
Condition(s) studied
Investigational drug(s) / intervention(s)
Baricitinib: Administered orally
Adalimumab: Administered SC
Study summary
The reason for this study is to see if the study drug baricitinib given orally is safe and effective in participants with active juvenile idiopathic arthritis (JIA)-associated uveitis or chronic anterior antinuclear antibody-positive uveitis from 2 years to less than 18 years old.
Eligibility
Primary outcome measure(s)
- Part A: Percentage of Responders for Baricitinib at Week 24 — Week 24
Response was defined according to the Standardization of Uveitis Nomenclature (SUN) criteria as a 2-step decrease in the level of inflammation (anterior chamber cells) or decrease to zero through week 24, in the eye most severely affected at baseline.
Trial sites (20)
| Facility | City | Region | Status |
|---|---|---|---|
| Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre | Le Kremlin-Bicêtre | France | |
| Hôpital Universitaire Necker Enfants Malades | Paris | France | |
| Centre Hospitalier Universitaire de Poitiers | Poitiers | France | |
| Asklepios Klinik Sankt Augustin | Sankt Augustin | North Rhine-Westphalia | |
| HELIOS Klinikum Berlin-Buch | Berlin | Germany | |
| Charité Campus Virchow-Klinikum | Berlin | Germany | |
| Praxis Kinder- und Jugendrheumatologie Dr. Ivan Foeldvari | Hamburg | Germany | |
| Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico | Milan | Lombardy | |
| Azienda Ospedaliero Universitaria Meyer | Florence | Italy | |
| Hospital Sant Joan de Déu | Esplugues de Llobregat | Barcelona | |
| Hospital Infantil Universitario Niño Jesús | Madrid | Madrid, Comunidad de | |
| Hospital Universitario La Paz | Madrid | Madrid, Comunidad de | |
| Hospital Universitario La Fe de Valencia | Valencia | Spain | |
| Bristol Royal Hospital for Children | Bristol | Bristol, City of | |
| Cambridge Clinical Research Facility | Cambridge | Cambridgeshire | |
| Alder Hey Children's Hospital | Liverpool | England | |
| Royal Victoria Infirmary | Newcastle upon Tyne | England | |
| University Hospital Southampton NHS Foundation Trust | Southampton | Hampshire | |
| Great Ormond Street Hospital For Children NHS Foundation Trust | London | United Kingdom | |
| Sheffield Children's Hospital | Sheffield | United Kingdom |
More Eli Lilly and Company trials in the UK
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT04088409 on ClinicalTrials.gov ↗ ← All trials in the UK