Chlorambucil clinical trials
Chlorambucil is named as an intervention in 6 current clinical trials in our France, China, UK, USA, Spain, Italy, Belgium, Sweden, Poland, Canada, Israel, Taiwan, Germany, Brazil, Australia, Egypt, Netherlands, Denmark, Czechia, Turkey and Switzerland registers. 1 is recruiting patients now. The most common phase is Phase 3. The sponsor with the most trials is Acerta Pharma BV (1). The most-studied condition is Chronic Lymphocytic Leukemia.
Where Chlorambucil is approved
All regulators →Of the three regulators tracked here, the first to approve Chlorambucil was the US, on 18 Mar 1957.
From the regulators' own registers: FDA Drugs@FDA, the EMA medicines list and Health Canada's Notice of Compliance database. Dates are the first listed approval of a product containing only this substance; combination products and nationally authorised EU medicines are not counted.
How Chlorambucil works
All drug targets →- B-cell chronic lymphocytic leukemiaPhase 3
- MALT lymphomaPhase 3
- Waldenstrom macroglobulinemiaPhase 3
- Focal segmental glomerulosclerosisPhase 3
- Follicular lymphomaPhase 3
- Gastric lymphomaPhase 3
- Lymphoplasmacytic lymphomaPhase 3
- Membranous glomerulonephritisPhase 3
- Non-Hodgkin lymphomaPhase 3
- Splenic marginal zone lymphomaPhase 3
Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL515, CC BY-SA 3.0. Targets checked against the IUPHAR/BPS Guide to PHARMACOLOGY (2026.3.1), ligand 7143, CC BY-SA 4.0. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.
Patient leaflets for Chlorambucil
The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.
- IEIreland: 1 product on the HPRA listEach product record links to the HPRA, which publishes the leaflet and SmPC.
- UKUnited Kingdom: Search MHRA ProductsPatient information leaflets and SmPCs for UK-licensed products.
- USUnited States: Search DailyMedFDA-approved labels, including patient and medication guides.
Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.
Reference identifiers for Chlorambucil
- ATC code
- L01AA02
- ChEMBL
- CHEMBL515
- DrugBank
- DB00291
- PubChem CID
- 2708
- CAS number
- 305-03-3
- FDA UNII
- 18D0SL7309
- Wikidata
- Q415939
- Wikipedia
- Chlorambucil
Codes that identify this medicine in other databases, from Wikidata (CC0), matched by its ChEMBL ID. The ATC code is the WHO classification of what the medicine is used for.
Trials by status
Trials by phase
Clinical trials of Chlorambucil
6 trialsRegisters list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.
Chlorambucil across our data
Ireland · EU · USThe same active substance in our other registers, matched by its exact name. Each entry links to the register record it comes from.
Licensed in Ireland (HPRA)
1 single-substance product containing Chlorambucil on the HPRA medicines list.
- Leukeran 2 mg film-coated tabletsAspen Pharma Trading Limited · PA1691/007/001 · Marketed
Supply shortages
No entry for Chlorambucil in the EMA, FDA or German BfArM shortage lists we track.
Conditions studied with Chlorambucil
6 conditionsSponsors
lead sponsor per trial| Lead sponsor | Trials |
|---|---|
| Acerta Pharma BV | 1 |
| Janssen Research & Development, LLC | 1 |
| BeOne Medicines | 1 |
| Ascentage Pharma Group Inc | 1 |
| AstraZeneca | 1 |
| International Extranodal Lymphoma Study Group (IELSG) | 1 |
By country register
A trial with sites in more than one country appears in each of those registers.
Related compounds
Questions about Chlorambucil trials
How many clinical trials are testing Chlorambucil?
6 current trials in our France, China, UK, USA, Spain, Italy, Belgium, Sweden, Poland, Canada, Israel, Taiwan, Germany, Brazil, Australia, Egypt, Netherlands, Denmark, Czechia, Turkey and Switzerland registers name Chlorambucil as a drug or biological intervention, as of the registry sync on 9 November 2026. Completed and withdrawn studies are not counted.
Are Chlorambucil trials recruiting patients?
Yes. 1 of the 6 trials is recruiting: 1 with sites in China. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.
Who sponsors Chlorambucil clinical trials?
Acerta Pharma BV (1), Janssen Research & Development, LLC (1), BeOne Medicines (1) and Ascentage Pharma Group Inc (1), among 6 lead sponsors in total. The number in brackets is how many trials each organisation leads.
Is Chlorambucil licensed in Ireland?
Yes. The HPRA medicines list includes 1 single-substance product containing Chlorambucil, for example Leukeran 2 mg film-coated tablets (Aspen Pharma Trading Limited). A licence does not mean a product is currently marketed or reimbursed; see each product's record.
Is there a Chlorambucil shortage?
Not in the lists we track: Chlorambucil has no entry in the EMA, FDA or German BfArM shortage registers as of their latest sync.
Where does this information come from?
Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Chlorambucil works or whether it is effective, and it is not medical advice.
How this page is built
Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Chlorambucil works or whether it is effective. Each trial links to its own record so you can check it yourself.
- ClinicalTrials.gov (U.S. National Library of Medicine) ↗ Trial IDs, titles, intervention names and synonyms, phase, overall status, lead sponsor and conditions for every trial on this page
This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Chlorambucil (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 9 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.