{
    "source_url": "https://clinicaltrials.gov",
    "register_url": "https://priyalifescience.com/clinical-trials-uk",
    "fetched_at": "2026-09-17T08:23:13+00:00",
    "registry_total_matching_open_statuses": 2852,
    "count": 2852,
    "page": 1,
    "per": 25,
    "results": [
        {
            "nct_id": "NCT07789483",
            "title": "An Open-Label Study to Evaluate the Long-Term Safety and Efficacy of ALXN2220 in Adults With Transthyretin Amyloid Cardiomyopathy",
            "status": "NOT_YET_RECRUITING",
            "phase": "Phase 3",
            "lead_sponsor": "Alexion Pharmaceuticals, Inc.",
            "conditions": [
                "Transthyretin Amyloid Cardiomyopathy (ATTR-CM)"
            ],
            "sites": [
                "Birmingham",
                "London",
                "Glasgow",
                "Cardiff",
                "Manchester"
            ],
            "enrollment": 1180,
            "start_date": "2027-11-23",
            "registry_url": "https://clinicaltrials.gov/study/NCT07789483"
        },
        {
            "nct_id": "NCT07441408",
            "title": "Long-term Extension Study to Evaluate Safety and Tolerability of Admilparant in Participants With Pulmonary Fibrosis",
            "status": "NOT_YET_RECRUITING",
            "phase": "Phase 3",
            "lead_sponsor": "Bristol-Myers Squibb",
            "conditions": [
                "Pulmonary Fibrosis"
            ],
            "sites": [
                "Birmingham",
                "Cambridge",
                "Edinburgh",
                "London",
                "Peterborough",
                "Cottingham",
                "Leeds",
                "Oxford"
            ],
            "enrollment": 2380,
            "start_date": "2026-12-16",
            "registry_url": "https://clinicaltrials.gov/study/NCT07441408"
        },
        {
            "nct_id": "NCT07815574",
            "title": "iSCIB1+ in Combination With Ipilimumab and Nivolumab as First-Line Treatment for Advanced Unresectable Melanoma",
            "status": "NOT_YET_RECRUITING",
            "phase": "Phase 3",
            "lead_sponsor": "Scancell Ltd",
            "conditions": [
                "Melanoma (Skin Cancer)",
                "Advanced Melanoma",
                "Metastatic Melanoma",
                "Skin Cancer"
            ],
            "sites": [
                "London"
            ],
            "enrollment": 550,
            "start_date": "2026-12-01",
            "registry_url": "https://clinicaltrials.gov/study/NCT07815574"
        },
        {
            "nct_id": "NCT07728188",
            "title": "A Study to Evaluate Adverse Events and Change in Disease Activity With Injected Etentamig Plus Oral Pomalidomide Versus Standard Therapies in Adults With Relapsed or Refractory Multiple Myeloma",
            "status": "NOT_YET_RECRUITING",
            "phase": "Phase 3",
            "lead_sponsor": "AbbVie",
            "conditions": [
                "Relapsed or Refractory Multiple Myeloma"
            ],
            "sites": [
                "Plymouth",
                "Edinburgh",
                "London",
                "Portsmouth",
                "Airdrie",
                "Nottingham"
            ],
            "enrollment": 520,
            "start_date": "2026-11-30",
            "registry_url": "https://clinicaltrials.gov/study/NCT07728188"
        },
        {
            "nct_id": "NCT07717411",
            "title": "A Study of Trontinemab in Cognitively Unimpaired Individuals at Risk for Progression to Symptomatic Alzheimer's Disease",
            "status": "RECRUITING",
            "phase": "Phase 3",
            "lead_sponsor": "Hoffmann-La Roche",
            "conditions": [
                "Alzheimer's Disease"
            ],
            "sites": [
                "Chertsey"
            ],
            "enrollment": 1600,
            "start_date": "2026-11-30",
            "registry_url": "https://clinicaltrials.gov/study/NCT07717411"
        },
        {
            "nct_id": "NCT07032038",
            "title": "First In Human Randomised Trial of Rincell-1 in Adults With a Cochlear Implant",
            "status": "NOT_YET_RECRUITING",
            "phase": "Phase 1/2",
            "lead_sponsor": "Rinri Therapeutics",
            "conditions": [
                "Sensorineural Hearing Loss",
                "Presbyacusis",
                "Auditory Neuropathy"
            ],
            "sites": [
                "Birmingham",
                "Cambridge",
                "London"
            ],
            "enrollment": 20,
            "start_date": "2026-11",
            "registry_url": "https://clinicaltrials.gov/study/NCT07032038"
        },
        {
            "nct_id": "NCT07744386",
            "title": "A Study in Healthy Male Participants to Compare How CHF10196 Affects How the Body Absorbs and Processes Two Commonly Used Medicines: Dabigatran, a Blood Thinner, and Rosuvastatin, a Medicine Used to Lower Cholesterol",
            "status": "NOT_YET_RECRUITING",
            "phase": "Phase 1",
            "lead_sponsor": "Chiesi Farmaceutici S.p.A.",
            "conditions": [
                "Healthy Male Volunteers"
            ],
            "sites": [
                "Leeds"
            ],
            "enrollment": 24,
            "start_date": "2026-10-27",
            "registry_url": "https://clinicaltrials.gov/study/NCT07744386"
        },
        {
            "nct_id": "NCT07401901",
            "title": "Evaluation of the Safety and Effectiveness of the Novel Medtronic Experimental Automated Insulin Delivery System (NMX8) in Adults Living With Type 1 Diabetes",
            "status": "NOT_YET_RECRUITING",
            "phase": "Not applicable",
            "lead_sponsor": "Medtronic MiniMed, Inc.",
            "conditions": [
                "Type 1 Diabetes (T1D)"
            ],
            "sites": [
                "Cambridge",
                "Leicester",
                "Manchester"
            ],
            "enrollment": 230,
            "start_date": "2026-10-15",
            "registry_url": "https://clinicaltrials.gov/study/NCT07401901"
        },
        {
            "nct_id": "NCT07683793",
            "title": "A Study to Compare How CHF10196 (Florensocatib) is Absorbed Into the Blood When Given Alone and With a Drug That Reduces Stomach Acid in Healthy Male Participants",
            "status": "NOT_YET_RECRUITING",
            "phase": "Phase 1",
            "lead_sponsor": "Chiesi Farmaceutici S.p.A.",
            "conditions": [
                "Healthy Volunteers"
            ],
            "sites": [
                "Leeds"
            ],
            "enrollment": 18,
            "start_date": "2026-10-14",
            "registry_url": "https://clinicaltrials.gov/study/NCT07683793"
        },
        {
            "nct_id": "NCT07796165",
            "title": "SNIP follow-on Case Series Using v3 Device",
            "status": "NOT_YET_RECRUITING",
            "phase": "Not applicable",
            "lead_sponsor": "Europa Life Sciences Limited",
            "conditions": [
                "Ankyloglossia"
            ],
            "sites": [
                "Royal Tunbridge Wells"
            ],
            "enrollment": 6,
            "start_date": "2026-10-01",
            "registry_url": "https://clinicaltrials.gov/study/NCT07796165"
        },
        {
            "nct_id": "NCT07802366",
            "title": "Acceptability and Tolerance Market Research of a Slow Release, Phenylalanine-free Protein Substitute for the Dietary Management of Phenylketonuria",
            "status": "NOT_YET_RECRUITING",
            "phase": "Not applicable",
            "lead_sponsor": "metaX Institut fuer Diatetik GmbH",
            "conditions": [
                "Phenylketonuria (PKU) and Hyperphenylalaninemia",
                "Brain Diseases, Metabolic, Inborn",
                "Brain Disorder, Metabolic",
                "Brain Diseases"
            ],
            "sites": [
                "Birmingham"
            ],
            "enrollment": 10,
            "start_date": "2026-10-01",
            "registry_url": "https://clinicaltrials.gov/study/NCT07802366"
        },
        {
            "nct_id": "NCT07622472",
            "title": "Remote Monitoring and Optimization of Heart Failure Therapy",
            "status": "NOT_YET_RECRUITING",
            "phase": "Not applicable",
            "lead_sponsor": "Zoll Medical Corporation",
            "conditions": [
                "Heart Failure"
            ],
            "sites": [
                "Southampton"
            ],
            "enrollment": 800,
            "start_date": "2026-10-01",
            "registry_url": "https://clinicaltrials.gov/study/NCT07622472"
        },
        {
            "nct_id": "NCT07762027",
            "title": "A Study to Assess the Safety, Pharmacokinetics, and Efficacy of ABI-6250 in Participants With Chronic Hepatitis D Virus Infection",
            "status": "NOT_YET_RECRUITING",
            "phase": "Phase 2",
            "lead_sponsor": "Assembly Biosciences",
            "conditions": [
                "Chronic Hepatitis D Infection"
            ],
            "sites": [
                "London",
                "Manchester"
            ],
            "enrollment": 80,
            "start_date": "2026-10",
            "registry_url": "https://clinicaltrials.gov/study/NCT07762027"
        },
        {
            "nct_id": "NCT07808151",
            "title": "Neoadjuvant Pembrolizumab and Porustobart in Resectable pMMR/MSS Colon Cancer",
            "status": "NOT_YET_RECRUITING",
            "phase": "Phase 2",
            "lead_sponsor": "Solstice Oncology, Inc.",
            "conditions": [
                "Colon Cancer",
                "Microsatellite Stable (MSS) Colon Cancer",
                "Proficient Mismatch Repair (pMMR) Colon Cancer"
            ],
            "sites": [
                "Aberdeen",
                "Cardiff",
                "Glasgow",
                "Leeds",
                "London"
            ],
            "enrollment": 100,
            "start_date": "2026-09-30",
            "registry_url": "https://clinicaltrials.gov/study/NCT07808151"
        },
        {
            "nct_id": "NCT07707895",
            "title": "DAREON\u00ae-36: A Study to Test Obrixtamig in Combination With ZL-1310 in People With Advanced Small Cell Lung Cancer or Other Neuroendocrine Cancers",
            "status": "NOT_YET_RECRUITING",
            "phase": "Phase 1/2",
            "lead_sponsor": "Boehringer Ingelheim",
            "conditions": [
                "Small Cell Lung Cancer",
                "Large Cell Neuroendocrine Lung Carcinoma",
                "Extrapulmonary Neuroendocrine Carcinoma of Small Cell Histology",
                "Extrapulmonary Neuroendocrine Carcinoma of Large Cell Histology"
            ],
            "sites": [
                "Leicester",
                "Newcastle upon Tyne"
            ],
            "enrollment": 60,
            "start_date": "2026-09-29",
            "registry_url": "https://clinicaltrials.gov/study/NCT07707895"
        },
        {
            "nct_id": "NCT07768189",
            "title": "A Study to Evaluate CRB-701 Compared to Investigator's Choice Therapy in Previously Treated Oropharyngeal Squamous Cell Carcinoma",
            "status": "NOT_YET_RECRUITING",
            "phase": "Phase 3",
            "lead_sponsor": "Corbus Pharmaceuticals Inc.",
            "conditions": [
                "Oropharyngeal Carcinoma (OPC)"
            ],
            "sites": [
                "London"
            ],
            "enrollment": 260,
            "start_date": "2026-09-20",
            "registry_url": "https://clinicaltrials.gov/study/NCT07768189"
        },
        {
            "nct_id": "NCT07540988",
            "title": "FIBRONEER-ACT: A Study to Test Whether Nerandomilast Helps People With Fibrosing Interstitial Lung Disease at Risk for Disease Progression",
            "status": "NOT_YET_RECRUITING",
            "phase": "Phase 3",
            "lead_sponsor": "Boehringer Ingelheim",
            "conditions": [
                "Interstitial Lung Diseases"
            ],
            "sites": [
                "Birmingham",
                "Exeter",
                "Leeds",
                "Leicester",
                "London",
                "Manchester",
                "Oxford"
            ],
            "enrollment": 466,
            "start_date": "2026-09-14",
            "registry_url": "https://clinicaltrials.gov/study/NCT07540988"
        },
        {
            "nct_id": "NCT07648264",
            "title": "Single-arm Study of IgPro20 in Adults With Secondary Immune Deficiencies Due to Hematologic Malignancies Treated With B-cell Targeting Chimeric Antigen Receptor T-cell and T-cell Redirecting Therapies",
            "status": "RECRUITING",
            "phase": "Phase 3",
            "lead_sponsor": "CSL Behring",
            "conditions": [
                "Secondary Immune Deficiency"
            ],
            "sites": [
                "London",
                "Leicester"
            ],
            "enrollment": 63,
            "start_date": "2026-09-11",
            "registry_url": "https://clinicaltrials.gov/study/NCT07648264"
        },
        {
            "nct_id": "NCT07811193",
            "title": "A Study to Evaluate the Efficacy of VVD-133214 in Combination With Pembrolizumab Compared With Pembrolizumab Alone in Participants With Advanced Cancer of the Colon or Rectum",
            "status": "RECRUITING",
            "phase": "Phase 2",
            "lead_sponsor": "Vividion Therapeutics, Inc.",
            "conditions": [
                "Colorectal Adenocarcinoma"
            ],
            "sites": [
                "London",
                "Coventry"
            ],
            "enrollment": 140,
            "start_date": "2026-09-11",
            "registry_url": "https://clinicaltrials.gov/study/NCT07811193"
        },
        {
            "nct_id": "NCT07810010",
            "title": "Phase 2b Study of a Respiratory Syncytial Virus and Human Metapneumovirus (RSV+HMPV) Protein Vaccine Candidate in Adults 60 Years of Age and Older",
            "status": "RECRUITING",
            "phase": "Phase 2",
            "lead_sponsor": "Sanofi",
            "conditions": [
                "Respiratory Syncytial Virus",
                "Human Metapneumovirus",
                "Healthy Volunteers"
            ],
            "sites": [
                "Cardiff",
                "Bournemouth",
                "Dorchester",
                "London",
                "Portsmouth",
                "Blackpool",
                "Witney",
                "West Kirby"
            ],
            "enrollment": 8000,
            "start_date": "2026-09-09",
            "registry_url": "https://clinicaltrials.gov/study/NCT07810010"
        },
        {
            "nct_id": "NCT07640984",
            "title": "A Phase I/II Trial of JR-446 in Mucopolysaccharidosis Type IIIB (MPS IIIB)",
            "status": "NOT_YET_RECRUITING",
            "phase": "Phase 1/2",
            "lead_sponsor": "JCR Pharmaceuticals Co., Ltd.",
            "conditions": [
                "Mucopolysaccharidosis IIIB"
            ],
            "sites": [
                "London"
            ],
            "enrollment": 12,
            "start_date": "2026-09-09",
            "registry_url": "https://clinicaltrials.gov/study/NCT07640984"
        },
        {
            "nct_id": "NCT07672574",
            "title": "Human Mass Balance Study of [14C] Ontunisertib in Healthy Volunteers",
            "status": "RECRUITING",
            "phase": "Phase 1",
            "lead_sponsor": "Agomab Spain S.L.U.",
            "conditions": [
                "Fibrostenotic Crohn's Disease"
            ],
            "sites": [
                "Nottingham"
            ],
            "enrollment": 8,
            "start_date": "2026-09-09",
            "registry_url": "https://clinicaltrials.gov/study/NCT07672574"
        },
        {
            "nct_id": "NCT07623200",
            "title": "A Phase 3 Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia",
            "status": "RECRUITING",
            "phase": "Phase 3",
            "lead_sponsor": "Incyte Corporation",
            "conditions": [
                "Essential Thrombocythemia"
            ],
            "sites": [
                "Cambridge",
                "Edinburgh",
                "Harrow",
                "Leeds",
                "London",
                "Newcastle upon Tyne",
                "Oxford",
                "Penzance"
            ],
            "enrollment": 426,
            "start_date": "2026-09-08",
            "registry_url": "https://clinicaltrials.gov/study/NCT07623200"
        },
        {
            "nct_id": "NCT07623161",
            "title": "A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib",
            "status": "RECRUITING",
            "phase": "Phase 3",
            "lead_sponsor": "Takeda",
            "conditions": [
                "Myelofibrosis",
                "Anemia"
            ],
            "sites": [
                "Lincoln",
                "Leicester",
                "London",
                "Sunderland",
                "Birmingham"
            ],
            "enrollment": 324,
            "start_date": "2026-09-02",
            "registry_url": "https://clinicaltrials.gov/study/NCT07623161"
        },
        {
            "nct_id": "NCT07746843",
            "title": "The Efficacy and Safety Study of 2107 Injection in Subjects With Mild to Moderate Knee Osteoarthritis",
            "status": "NOT_YET_RECRUITING",
            "phase": "Not applicable",
            "lead_sponsor": "BioRegen Biomedical (Changzhou) Co., Ltd",
            "conditions": [
                "Mild Knee Osteoarthritis",
                "Moderate Knee Osteoarthritis"
            ],
            "sites": [
                "Glasgow"
            ],
            "enrollment": 286,
            "start_date": "2026-09-01",
            "registry_url": "https://clinicaltrials.gov/study/NCT07746843"
        }
    ]
}