{ "source_url": "https://clinicaltrials.gov", "register_url": "https://priyalifescience.com/clinical-trials-uk", "fetched_at": "2026-11-01T03:15:22+00:00", "registry_total_matching_open_statuses": 2886, "count": 2885, "page": 1, "per": 500, "results": [ { "nct_id": "NCT07789483", "title": "An Open-Label Study to Evaluate the Long-Term Safety and Efficacy of ALXN2220 in Adults With Transthyretin Amyloid Cardiomyopathy", "status": "NOT_YET_RECRUITING", "phase": "Phase 3", "lead_sponsor": "Alexion Pharmaceuticals, Inc.", "conditions": [ "Transthyretin Amyloid Cardiomyopathy (ATTR-CM)" ], "sites": [ "Birmingham", "London", "Glasgow", "Cardiff", "Manchester" ], "enrollment": 1180, "start_date": "2027-11-23", "registry_url": "https://clinicaltrials.gov/study/NCT07789483" }, { "nct_id": "NCT07032038", "title": "First In Human Randomised Trial of Rincell-1 in Adults With a Cochlear Implant", "status": "NOT_YET_RECRUITING", "phase": "Phase 1/2", "lead_sponsor": "Rinri Therapeutics", "conditions": [ "Sensorineural Hearing Loss", "Presbyacusis", "Auditory Neuropathy" ], "sites": [ "Birmingham", "Cambridge", "London" ], "enrollment": 20, "start_date": "2027-09", "registry_url": "https://clinicaltrials.gov/study/NCT07032038" }, { "nct_id": "NCT01894308", "title": "A Dose Ranging Study to Examine TDS-Testosterone 5%", "status": "NOT_YET_RECRUITING", "phase": "Phase 2", "lead_sponsor": "Transdermal Delivery Solutions Corp", "conditions": [ "Hypogonadotropism" ], "sites": [ "London" ], "enrollment": 48, "start_date": "2027-06", "registry_url": "https://clinicaltrials.gov/study/NCT01894308" }, { "nct_id": "NCT07335562", "title": "A Study to Compare the Efficacy and Safety of BMS-986353 (Zolacabtagene- Autoleucel / Zola-cel), CD19-CAR T Cells, Versus Standard of Care in Participants With Active Systemic Sclerosis", "status": "NOT_YET_RECRUITING", "phase": "Phase 3", "lead_sponsor": "Juno Therapeutics, Inc., a Bristol-Myers Squibb Company", "conditions": [ "Systemic Sclerosis" ], "sites": [ "London", "Leeds", "Sheffield" ], "enrollment": 92, "start_date": "2027-02-03", "registry_url": "https://clinicaltrials.gov/study/NCT07335562" }, { "nct_id": "NCT07898774", "title": "To Assess the Efficacy and Safety of Pegcetacoplan for the Prevention of Recurrent C3G or Primary IC-MPGN in Kidney Transplant Recipients", "status": "NOT_YET_RECRUITING", "phase": "Phase 3", "lead_sponsor": "Swedish Orphan Biovitrum", "conditions": [ "C3 Glomerulopathy (C3G)", "Primary Immune-Complex Membranoproliferative", "Glomerulonephritis (IC-MPGN)", "Kidney Transplantation" ], "sites": [ "London", "Manchester", "Newcastle upon Tyne" ], "enrollment": 30, "start_date": "2027-01-21", "registry_url": "https://clinicaltrials.gov/study/NCT07898774" }, { "nct_id": "NCT07841457", "title": "Early Probiotic Research: Open-label Functional Intervention and Longitudinal Evaluation in Healthy Adults", "status": "NOT_YET_RECRUITING", "phase": "Not applicable", "lead_sponsor": "OneCarbon", "conditions": [ "Probiotic Intervention", "Healthy Adult Participants" ], "sites": [ "Cambridge" ], "enrollment": 20, "start_date": "2027-01-01", "registry_url": "https://clinicaltrials.gov/study/NCT07841457" }, { "nct_id": "NCT06384599", "title": "VT Cryoablation System Post-Market Clinical Follow-up (PMCF) Study", "status": "NOT_YET_RECRUITING", "phase": "Not applicable", "lead_sponsor": "Adagio Medical", "conditions": [ "Ventricular Tachycardia" ], "sites": [ "Basildon" ], "enrollment": 130, "start_date": "2027-01-01", "registry_url": "https://clinicaltrials.gov/study/NCT06384599" }, { "nct_id": "NCT07849036", "title": "A Real-world Study of Gastrointestinal Health and Mental Wellness in U.S. Adults Following 12 Weeks of Probiotic Supplementation.", "status": "NOT_YET_RECRUITING", "phase": "Not applicable", "lead_sponsor": "Novonesis", "conditions": [ "Healthy Adults Reporting Recurrent Gastrointestinal Symptoms" ], "sites": [ "Cardiff" ], "enrollment": 300, "start_date": "2027-01", "registry_url": "https://clinicaltrials.gov/study/NCT07849036" }, { "nct_id": "NCT07441408", "title": "Long-term Extension Study to Evaluate Safety and Tolerability of Admilparant in Participants With Pulmonary Fibrosis", "status": "NOT_YET_RECRUITING", "phase": "Phase 3", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Pulmonary Fibrosis" ], "sites": [ "Birmingham", "Cambridge", "Edinburgh", "London", "Peterborough", "Cottingham", "Leeds", "Oxford" ], "enrollment": 2380, "start_date": "2026-12-16", "registry_url": "https://clinicaltrials.gov/study/NCT07441408" }, { "nct_id": "NCT07789015", "title": "A Study to Understand How Nerandomilast Works in People With Active Idiopathic Inflammatory Myopathies", "status": "NOT_YET_RECRUITING", "phase": "Phase 3", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Idiopathic Inflammatory Myopathies" ], "sites": [ "Birmingham", "Bristol", "Doncaster", "Edinburgh", "Harrow", "Liverpool", "Salford", "Wolverhampton" ], "enrollment": 270, "start_date": "2026-12-14", "registry_url": "https://clinicaltrials.gov/study/NCT07789015" }, { "nct_id": "NCT07815574", "title": "iSCIB1+ in Combination With Ipilimumab and Nivolumab as First-Line Treatment for Advanced Unresectable Melanoma", "status": "NOT_YET_RECRUITING", "phase": "Phase 3", "lead_sponsor": "Scancell Ltd", "conditions": [ "Melanoma (Skin Cancer)", "Advanced Melanoma", "Metastatic Melanoma", "Skin Cancer" ], "sites": [ "London" ], "enrollment": 550, "start_date": "2026-12-01", "registry_url": "https://clinicaltrials.gov/study/NCT07815574" }, { "nct_id": "NCT07480395", "title": "Real-World Data Collection of GORE Devices Used In the Endovascular Treatment of Aortic Aneurysms Which Incorporate Visceral Arteries.", "status": "NOT_YET_RECRUITING", "phase": "Observational", "lead_sponsor": "W.L.Gore & Associates", "conditions": [ "Complex Aortic Aneurysms", "Thoracoabdominal Aneurysm", "Fenestrated Endovascular Aortic Repair", "Endovascular Aortic Repair" ], "sites": [ "Birmingham", "London", "Manchester" ], "enrollment": 400, "start_date": "2026-12", "registry_url": "https://clinicaltrials.gov/study/NCT07480395" }, { "nct_id": "NCT07881432", "title": "A Study of EloraTZP in Adult Participants With Obesity Without Type 2 Diabetes", "status": "NOT_YET_RECRUITING", "phase": "Phase 3", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Obesity" ], "sites": [ "Blackpool", "Lancashire", "London", "Penzance", "Romsey", "West Kirby" ], "enrollment": 2115, "start_date": "2026-12", "registry_url": "https://clinicaltrials.gov/study/NCT07881432" }, { "nct_id": "NCT07871214", "title": "A Study to Assess The Safety and Tolerability of Pumitamig-Based Therapy Administered Before Surgery in Participants With Early-Stage Non-Small Cell Lung Cancer (ROSETTA Lung-220)", "status": "NOT_YET_RECRUITING", "phase": "Phase 2", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Early-Stage Non-Small Cell Lung Cancer" ], "sites": [ "Leicester", "Metropolitan Borough of Wirral", "London" ], "enrollment": 80, "start_date": "2026-11-30", "registry_url": "https://clinicaltrials.gov/study/NCT07871214" }, { "nct_id": "NCT07728188", "title": "A Study to Evaluate Adverse Events and Change in Disease Activity With Injected Etentamig Plus Oral Pomalidomide Versus Standard Therapies in Adults With Relapsed or Refractory Multiple Myeloma", "status": "NOT_YET_RECRUITING", "phase": "Phase 3", "lead_sponsor": "AbbVie", "conditions": [ "Relapsed or Refractory Multiple Myeloma" ], "sites": [ "Plymouth", "Edinburgh", "London", "Portsmouth", "Airdrie", "Nottingham" ], "enrollment": 520, "start_date": "2026-11-30", "registry_url": "https://clinicaltrials.gov/study/NCT07728188" }, { "nct_id": "NCT07717411", "title": "A Study of Trontinemab in Cognitively Unimpaired Individuals at Risk for Progression to Symptomatic Alzheimer's Disease", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Alzheimer's Disease" ], "sites": [ "Aberdeen", "Birmingham", "Chertsey", "Edinburgh", "London", "Southampton" ], "enrollment": 1600, "start_date": "2026-11-30", "registry_url": "https://clinicaltrials.gov/study/NCT07717411" }, { "nct_id": "NCT07850063", "title": "ELEVATE-LIVER: A Study to Test Whether Survodutide Helps Improve Heart Structure and Function in People With Overweight or Obesity and Fatty Liver Disease", "status": "NOT_YET_RECRUITING", "phase": "Phase 3", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Obesity", "Metabolic Dysfunction-associated Steatotic Liver Disease" ], "sites": [ "Bradford", "Leeds", "Leicester", "London", "Plymouth" ], "enrollment": 600, "start_date": "2026-11-02", "registry_url": "https://clinicaltrials.gov/study/NCT07850063" }, { "nct_id": "NCT06531031", "title": "Clinical Performance Study of Microbio InfectID-BSI for Detection of Bacteria and Yeast With Patient Blood Samples", "status": "NOT_YET_RECRUITING", "phase": "Observational", "lead_sponsor": "Microbio Co Ltd", "conditions": [ "Bloodstream Infection", "Sepsis", "Septic Shock" ], "sites": [ "Bristol" ], "enrollment": 1500, "start_date": "2026-11", "registry_url": "https://clinicaltrials.gov/study/NCT06531031" }, { "nct_id": "NCT07904715", "title": "Tolerance and Acceptability of an Oral Nutrition Supplement", "status": "NOT_YET_RECRUITING", "phase": "Not applicable", "lead_sponsor": "Aymes International Limited", "conditions": [ "Disease Related Malnutrition" ], "sites": [ "Nottingham" ], "enrollment": 20, "start_date": "2026-11", "registry_url": "https://clinicaltrials.gov/study/NCT07904715" }, { "nct_id": "NCT07850050", "title": "SYNCHRONIZE\u00ae-HERA: A Study to Test Whether Survodutide Helps Women Who Are Living With Overweight or Obesity and Are Going Through or Have Finished Menopause, to Lose Weight", "status": "NOT_YET_RECRUITING", "phase": "Phase 3", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Obesity" ], "sites": [ "Glasgow", "Leicester" ], "enrollment": 600, "start_date": "2026-10-31", "registry_url": "https://clinicaltrials.gov/study/NCT07850050" }, { "nct_id": "NCT07683325", "title": "NOV-ERA - A Clinical Trial to Assess the Efficacy and Safety of Ontunisertib Compared to Placebo in Patients With Fibrostenosing Crohn's Disease", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Agomab Spain S.L.U.", "conditions": [ "Fibrostenotic Crohn's Disease" ], "sites": [ "London" ], "enrollment": 320, "start_date": "2026-10-30", "registry_url": "https://clinicaltrials.gov/study/NCT07683325" }, { "nct_id": "NCT07707895", "title": "DAREON\u00ae-36: A Study to Test Obrixtamig in Combination With ZL-1310 in People With Advanced Small Cell Lung Cancer or Other Neuroendocrine Cancers", "status": "NOT_YET_RECRUITING", "phase": "Phase 1/2", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Small Cell Lung Cancer", "Large Cell Neuroendocrine Lung Carcinoma", "Extrapulmonary Neuroendocrine Carcinoma of Small Cell Histology", "Extrapulmonary Neuroendocrine Carcinoma of Large Cell Histology" ], "sites": [ "Leicester", "Newcastle upon Tyne" ], "enrollment": 60, "start_date": "2026-10-28", "registry_url": "https://clinicaltrials.gov/study/NCT07707895" }, { "nct_id": "NCT07744386", "title": "A Study in Healthy Male Participants to Compare How CHF10196 Affects How the Body Absorbs and Processes Two Commonly Used Medicines: Dabigatran, a Blood Thinner, and Rosuvastatin, a Medicine Used to Lower Cholesterol", "status": "NOT_YET_RECRUITING", "phase": "Phase 1", "lead_sponsor": "Chiesi Farmaceutici S.p.A.", "conditions": [ "Healthy Male Volunteers" ], "sites": [ "Leeds" ], "enrollment": 24, "start_date": "2026-10-27", "registry_url": "https://clinicaltrials.gov/study/NCT07744386" }, { "nct_id": "NCT07861100", "title": "A Research Study to Look at How Well Zenagamtide Works Compared to Placebo in People With Established Atherosclerotic Cardiovascular Disease and Either Overweight or Obesity", "status": "NOT_YET_RECRUITING", "phase": "Phase 3", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Cardiovascular Risk", "Obesity" ], "sites": [ "Newquay", "Poole", "Thetford", "West Bromwich", "Chichester", "West Kirby", "Aberdeen", "Ashton-under-Lyne" ], "enrollment": 8500, "start_date": "2026-10-26", "registry_url": "https://clinicaltrials.gov/study/NCT07861100" }, { "nct_id": "NCT07898306", "title": "Nasal Residency of HEX17", "status": "NOT_YET_RECRUITING", "phase": "Phase 1", "lead_sponsor": "Pneumagen Ltd, a subsidiary of NorthLinks Bio", "conditions": [ "Healthy Volunteers" ], "sites": [ "Manchester" ], "enrollment": 44, "start_date": "2026-10-20", "registry_url": "https://clinicaltrials.gov/study/NCT07898306" }, { "nct_id": "NCT07822334", "title": "A Study of RO7830698 in Healthy Participants and Participants With Chronic Obstructive Pulmonary Disease", "status": "RECRUITING", "phase": "Phase 1/2", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Chronic Obstructive Pulmonary Disease (COPD)", "Healthy Participants" ], "sites": [ "Wythenshawe" ], "enrollment": 104, "start_date": "2026-10-20", "registry_url": "https://clinicaltrials.gov/study/NCT07822334" }, { "nct_id": "NCT07843368", "title": "Safety, Tolerability, PK, and PD of TGM-148 in Healthy Participants", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "Tangram Therapeutics Plc", "conditions": [ "Healthy Participants" ], "sites": [ "London" ], "enrollment": 40, "start_date": "2026-10-16", "registry_url": "https://clinicaltrials.gov/study/NCT07843368" }, { "nct_id": "NCT07830732", "title": "A Research Study Investigating Denecimig (Mim8) in Adults With Acquired Haemophilia A", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Haemophilia A" ], "sites": [ "Birmingham", "Cardiff", "London", "Oxford", "Sheffield" ], "enrollment": 84, "start_date": "2026-10-16", "registry_url": "https://clinicaltrials.gov/study/NCT07830732" }, { "nct_id": "NCT07401901", "title": "Evaluation of the Safety and Effectiveness of the Novel Medtronic Experimental Automated Insulin Delivery System (NMX8) in Adults Living With Type 1 Diabetes", "status": "NOT_YET_RECRUITING", "phase": "Not applicable", "lead_sponsor": "Medtronic MiniMed, Inc.", "conditions": [ "Type 1 Diabetes (T1D)" ], "sites": [ "Cambridge", "Leicester", "Manchester" ], "enrollment": 230, "start_date": "2026-10-15", "registry_url": "https://clinicaltrials.gov/study/NCT07401901" }, { "nct_id": "NCT07802366", "title": "Market Research of a Slow Release Protein Substitute for the Dietary Management of PKU", "status": "NOT_YET_RECRUITING", "phase": "Not applicable", "lead_sponsor": "metaX Institut fuer Diatetik GmbH", "conditions": [ "Phenylketonuria (PKU) and Hyperphenylalaninemia", "Brain Diseases, Metabolic, Inborn", "Brain Disorder, Metabolic", "Brain Diseases" ], "sites": [ "Birmingham" ], "enrollment": 10, "start_date": "2026-10-15", "registry_url": "https://clinicaltrials.gov/study/NCT07802366" }, { "nct_id": "NCT07683793", "title": "A Study to Compare How CHF10196 (Florensocatib) is Absorbed Into the Blood When Given Alone and With a Drug That Reduces Stomach Acid in Healthy Male Participants", "status": "NOT_YET_RECRUITING", "phase": "Phase 1", "lead_sponsor": "Chiesi Farmaceutici S.p.A.", "conditions": [ "Healthy Volunteers" ], "sites": [ "Leeds" ], "enrollment": 18, "start_date": "2026-10-14", "registry_url": "https://clinicaltrials.gov/study/NCT07683793" }, { "nct_id": "NCT07473622", "title": "Outcome Research in Bowel Irrigation Techniques for the Treatment of Chronic Constipation and/or Faecal Incontinence", "status": "RECRUITING", "phase": "Not applicable", "lead_sponsor": "Qufora A/S", "conditions": [ "Faecal Incontinence", "Chronic Constipation" ], "sites": [ "Southampton" ], "enrollment": 66, "start_date": "2026-10-09", "registry_url": "https://clinicaltrials.gov/study/NCT07473622" }, { "nct_id": "NCT07837648", "title": "A Study to Test How Much BI 3034701 Gets Into the Blood in Healthy People When Given in Two Different Ways", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Healthy" ], "sites": [ "Nottingham" ], "enrollment": 30, "start_date": "2026-10-05", "registry_url": "https://clinicaltrials.gov/study/NCT07837648" }, { "nct_id": "NCT07851623", "title": "Evaluation of Safety, Side Effects, and How the Drug, Inhaled CHF10136, Is Absorbed, Modified and Removed From the Body in Healthy Adults and Adults With Asthma", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "Chiesi Farmaceutici S.p.A.", "conditions": [ "Asthma", "Healthy Volunteers" ], "sites": [ "Leeds", "London", "Manchester" ], "enrollment": 120, "start_date": "2026-10-02", "registry_url": "https://clinicaltrials.gov/study/NCT07851623" }, { "nct_id": "NCT07622472", "title": "Remote Monitoring and Optimization of Heart Failure Therapy", "status": "NOT_YET_RECRUITING", "phase": "Not applicable", "lead_sponsor": "Zoll Medical Corporation", "conditions": [ "Heart Failure" ], "sites": [ "Southampton" ], "enrollment": 800, "start_date": "2026-10-01", "registry_url": "https://clinicaltrials.gov/study/NCT07622472" }, { "nct_id": "NCT07671859", "title": "PKU Microtablets Case Studies", "status": "NOT_YET_RECRUITING", "phase": "Not applicable", "lead_sponsor": "Nutricia UK Ltd", "conditions": [ "Phenylketonuria (PKU)" ], "sites": [ "Bristol" ], "enrollment": 20, "start_date": "2026-10-01", "registry_url": "https://clinicaltrials.gov/study/NCT07671859" }, { "nct_id": "NCT07796165", "title": "SNIP follow-on Case Series Using v3 Device", "status": "NOT_YET_RECRUITING", "phase": "Not applicable", "lead_sponsor": "Europa Life Sciences Limited", "conditions": [ "Ankyloglossia" ], "sites": [ "Royal Tunbridge Wells" ], "enrollment": 6, "start_date": "2026-10-01", "registry_url": "https://clinicaltrials.gov/study/NCT07796165" }, { "nct_id": "NCT07896252", "title": "Phase 2b Efficacy and Safety Study of AERO-007, an Inhaled LABA+LAMA Combination for Nebulization Delivery in COPD Patients", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "AeroRx Therapeutics Inc.", "conditions": [ "COPD", "Chronic Obstructive Pulmonary Disease (COPD)", "Lung Disease Chronic", "Lung Diseases, Obstructive" ], "sites": [ "London", "Manchester" ], "enrollment": 64, "start_date": "2026-10", "registry_url": "https://clinicaltrials.gov/study/NCT07896252" }, { "nct_id": "NCT07887841", "title": "Effects of Probiotics on Skin Health in Healthy Women", "status": "NOT_YET_RECRUITING", "phase": "Not applicable", "lead_sponsor": "Probi AB", "conditions": [ "Skin Aging, Dry Skin" ], "sites": [ "Babraham" ], "enrollment": 140, "start_date": "2026-10", "registry_url": "https://clinicaltrials.gov/study/NCT07887841" }, { "nct_id": "NCT07347275", "title": "A Novel Extracorporeal Liver Support Therapy In ALCF and to Evaluate the Efficacy of DIALIVE 2.0, a Liver Dialysis Device.", "status": "RECRUITING", "phase": "Not applicable", "lead_sponsor": "Yaqrit Ltd", "conditions": [ "Acute-on-Chronic Liver Failure (ACLF)", "Liver Cirrhosis" ], "sites": [ "London" ], "enrollment": 72, "start_date": "2026-10", "registry_url": "https://clinicaltrials.gov/study/NCT07347275" }, { "nct_id": "NCT07672769", "title": "Bexmarilimab + Azacitidine Versus Placebo + Azacitidine in Participants With Treatment-na\u00efve Higher-risk Myelodysplastic Syndromes", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Faron Pharmaceuticals Ltd", "conditions": [ "Higher Risk Myelodysplastic Syndromes" ], "sites": [ "London", "Manchester", "Maidstone", "Birmingham", "Glasgow", "Truro" ], "enrollment": 90, "start_date": "2026-10", "registry_url": "https://clinicaltrials.gov/study/NCT07672769" }, { "nct_id": "NCT07900607", "title": "The Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]OD-001 in Healthy Male Participants", "status": "NOT_YET_RECRUITING", "phase": "Phase 1", "lead_sponsor": "Odyssey Therapeutics, Inc.", "conditions": [ "Health Volunteers" ], "sites": [ "Ruddington" ], "enrollment": 8, "start_date": "2026-10", "registry_url": "https://clinicaltrials.gov/study/NCT07900607" }, { "nct_id": "NCT07559175", "title": "A Study to Evaluate Safety and Explore Efficacy of New Lipase NHS7108 in Adult Participants With Exocrine Pancreatic Insufficiency.", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Aimmune Nestl\u00e9 Health Science US R&D, LLC", "conditions": [ "Exocrine Pancreatic Insufficiency (EPI)", "Cystic Fibrosis (CF)", "Pancreatic Enzyme Abnormality", "Pancreatic Diseases" ], "sites": [ "Liverpool", "Belfast", "Glasgow", "Newcastle upon Tyne" ], "enrollment": 66, "start_date": "2026-10", "registry_url": "https://clinicaltrials.gov/study/NCT07559175" }, { "nct_id": "NCT07762027", "title": "A Study to Assess the Safety, Pharmacokinetics, and Efficacy of ABI-6250 in Participants With Chronic Hepatitis D Virus Infection", "status": "NOT_YET_RECRUITING", "phase": "Phase 2", "lead_sponsor": "Assembly Biosciences", "conditions": [ "Chronic Hepatitis D Infection" ], "sites": [ "London", "Manchester" ], "enrollment": 80, "start_date": "2026-10", "registry_url": "https://clinicaltrials.gov/study/NCT07762027" }, { "nct_id": "NCT07782814", "title": "An Investigation Into Dielectric Testing for the Evaluation and Characterisation of Breast Tissue Using a Novel Time-Domain Bioimpedance Tool", "status": "RECRUITING", "phase": "Observational", "lead_sponsor": "Zedsen Limited", "conditions": [ "Breast Cancer", "Breast - Female" ], "sites": [ "London" ], "enrollment": 220, "start_date": "2026-09-30", "registry_url": "https://clinicaltrials.gov/study/NCT07782814" }, { "nct_id": "NCT07781644", "title": "Study to Test Effects and Safety of RO7568282 in Early Parkinson's Disease", "status": "NOT_YET_RECRUITING", "phase": "Phase 1/2", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Parkinson's Disease" ], "sites": [ "Dundee", "London" ], "enrollment": 474, "start_date": "2026-09-30", "registry_url": "https://clinicaltrials.gov/study/NCT07781644" }, { "nct_id": "NCT07808151", "title": "Neoadjuvant Pembrolizumab and Porustobart in Resectable pMMR/MSS Colon Cancer", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Solstice Oncology, Inc.", "conditions": [ "Colon Cancer" ], "sites": [ "Aberdeen", "Cardiff", "Glasgow", "Leeds", "London" ], "enrollment": 100, "start_date": "2026-09-30", "registry_url": "https://clinicaltrials.gov/study/NCT07808151" }, { "nct_id": "NCT07768189", "title": "A Study to Evaluate CRB-701 Compared to Investigator's Choice Therapy in Previously Treated Oropharyngeal Squamous Cell Carcinoma", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Corbus Pharmaceuticals Inc.", "conditions": [ "Oropharyngeal Carcinoma (OPC)" ], "sites": [ "London", "Sutton", "Birmingham", "Cambridge", "Glasgow", "Liverpool", "Manchester", "Nottingham" ], "enrollment": 260, "start_date": "2026-09-29", "registry_url": "https://clinicaltrials.gov/study/NCT07768189" }, { "nct_id": "NCT07751991", "title": "A Study of CHM-029 in Participants With NPM1 Mutated, KMT2A or NUP98 Rearranged AML", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "Charm Therapeutics", "conditions": [ "AML (Acute Myeloid Leukemia)" ], "sites": [ "Manchester", "Oxford" ], "enrollment": 40, "start_date": "2026-09-28", "registry_url": "https://clinicaltrials.gov/study/NCT07751991" }, { "nct_id": "NCT07842042", "title": "A Study Investigating Gingival Crevicular Fluid Biomarkers Following Use of a Commercially Available Toothpaste Containing Stannous Fluoride", "status": "RECRUITING", "phase": "Not applicable", "lead_sponsor": "HALEON", "conditions": [ "Dental Plaque", "Gingivitis" ], "sites": [ "Birmingham" ], "enrollment": 20, "start_date": "2026-09-28", "registry_url": "https://clinicaltrials.gov/study/NCT07842042" }, { "nct_id": "NCT07735637", "title": "A Phase III, Multicentre Study to Evaluate Consolidation Treatment With AZD0120 Compared With ASCT, in Participants With Newly Diagnosed Multiple Myeloma Who Are Transplant Eligible (DURGA-6).", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "AstraZeneca", "conditions": [ "Newly Diagnosed Multiple Myeloma (NDMM)" ], "sites": [ "Cambridge", "London" ], "enrollment": 750, "start_date": "2026-09-24", "registry_url": "https://clinicaltrials.gov/study/NCT07735637" }, { "nct_id": "NCT07761299", "title": "Versius Robotic Surgery in the NHS: A Multi-Specialty Retrospective Study", "status": "RECRUITING", "phase": "Observational", "lead_sponsor": "CMR Surgical Ltd", "conditions": [ "Robotic-assisted Soft-tissue Surgery" ], "sites": [ "London", "Manchester", "Southampton", "Swindon", "Watford" ], "enrollment": 1200, "start_date": "2026-09-22", "registry_url": "https://clinicaltrials.gov/study/NCT07761299" }, { "nct_id": "NCT07666828", "title": "Evaluation of Three Neuromuscular Electrical Stimulation Foot Pad Programmes on Lower Limb Haemodynamics in Healthy Adults", "status": "RECRUITING", "phase": "Not applicable", "lead_sponsor": "Joey Porter", "conditions": [ "Healthy" ], "sites": [ "Bracknell" ], "enrollment": 24, "start_date": "2026-09-22", "registry_url": "https://clinicaltrials.gov/study/NCT07666828" }, { "nct_id": "NCT07811999", "title": "Comparing the Extent to Which Romosozumab (AMG 785) is Made Available in the Body When Administered as a Single SC Injection or as 2 SC Injections", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "Amgen", "conditions": [ "Healthy Participants" ], "sites": [ "Leeds" ], "enrollment": 308, "start_date": "2026-09-22", "registry_url": "https://clinicaltrials.gov/study/NCT07811999" }, { "nct_id": "NCT07830719", "title": "Dose-finding Study of YMI024 to Assess Efficacy, Safety, and Tolerability in Adults With Stable Coronary Artery Disease and Elevated hsCRP", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Coronary Artery Disease" ], "sites": [ "London" ], "enrollment": 180, "start_date": "2026-09-18", "registry_url": "https://clinicaltrials.gov/study/NCT07830719" }, { "nct_id": "NCT07540988", "title": "FIBRONEER-ACT: A Study to Test Whether Nerandomilast Helps People With Fibrosing Interstitial Lung Disease at Risk for Disease Progression", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Interstitial Lung Diseases" ], "sites": [ "Birmingham", "Exeter", "Lancaster", "Leeds", "Leicester", "London", "Manchester", "Oxford" ], "enrollment": 466, "start_date": "2026-09-17", "registry_url": "https://clinicaltrials.gov/study/NCT07540988" }, { "nct_id": "NCT07793409", "title": "A Study to Evaluate the Long-term Safety and Efficacy of Lunsekimig in Adult Participants With Chronic Obstructive Pulmonary Disease (COPD)", "status": "ENROLLING_BY_INVITATION", "phase": "Phase 3", "lead_sponsor": "Sanofi", "conditions": [ "Chronic Obstructive Pulmonary Disease" ], "sites": [ "Chertsey", "Rotherham" ], "enrollment": 1508, "start_date": "2026-09-16", "registry_url": "https://clinicaltrials.gov/study/NCT07793409" }, { "nct_id": "NCT07711002", "title": "Saruparib in Combination With Physician's Choice of ARPI in Patients With mHSPC Previously Treated With Docetaxel or 177Lu-PSMA Therapy Without Disease Progression and PSA \u2265 0.2 ng/mL (EvoPAR-PR05)", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "AstraZeneca", "conditions": [ "Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)" ], "sites": [ "Cambridge", "Glasgow", "London", "Manchester", "Plymouth" ], "enrollment": 1330, "start_date": "2026-09-15", "registry_url": "https://clinicaltrials.gov/study/NCT07711002" }, { "nct_id": "NCT07648264", "title": "Single-arm Study of IgPro20 in Adults With Secondary Immune Deficiencies Due to Hematologic Malignancies Treated With B-cell Targeting Chimeric Antigen Receptor T-cell and T-cell Redirecting Therapies", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "CSL Behring", "conditions": [ "Secondary Immune Deficiency" ], "sites": [ "London", "Leicester" ], "enrollment": 63, "start_date": "2026-09-15", "registry_url": "https://clinicaltrials.gov/study/NCT07648264" }, { "nct_id": "NCT07789223", "title": "Weight and Metabolic Management Study", "status": "RECRUITING", "phase": "Not applicable", "lead_sponsor": "Elenzia", "conditions": [ "Overweight", "Obesity", "Weight Maintenance" ], "sites": [ "Redditch" ], "enrollment": 200, "start_date": "2026-09-15", "registry_url": "https://clinicaltrials.gov/study/NCT07789223" }, { "nct_id": "NCT07606365", "title": "A Study in Adults With Geographic Atrophy", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Sitala Bio LTD", "conditions": [ "Geographic Atrophy" ], "sites": [ "London", "Southampton", "Leicester", "Newcastle upon Tyne" ], "enrollment": 300, "start_date": "2026-09-11", "registry_url": "https://clinicaltrials.gov/study/NCT07606365" }, { "nct_id": "NCT07811193", "title": "A Study to Evaluate the Efficacy of VVD-133214 in Combination With Pembrolizumab Compared With Pembrolizumab Alone in Participants With Advanced Cancer of the Colon or Rectum", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Vividion Therapeutics, Inc.", "conditions": [ "Colorectal Adenocarcinoma" ], "sites": [ "London", "Coventry" ], "enrollment": 140, "start_date": "2026-09-11", "registry_url": "https://clinicaltrials.gov/study/NCT07811193" }, { "nct_id": "NCT07680764", "title": "A Study To Assess the Safety, Tolerability, and Efficacy of Imzokitug in Combination With Pumitamig and Platinum-Doublet Chemotherapy (PDCT) Versus Pumitamig and PDCT as First-line Treatment for Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Locally Advanced Non-Small Cell Lung Cancer (NSCLC)", "Metastatic Non-Small Cell Lung Cancer (NSCLC)" ], "sites": [ "Birmingham", "London", "Guildford" ], "enrollment": 160, "start_date": "2026-09-10", "registry_url": "https://clinicaltrials.gov/study/NCT07680764" }, { "nct_id": "NCT07623161", "title": "A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Takeda", "conditions": [ "Myelofibrosis", "Anemia" ], "sites": [ "Lincoln", "Leicester", "London", "Sunderland", "Birmingham" ], "enrollment": 324, "start_date": "2026-09-10", "registry_url": "https://clinicaltrials.gov/study/NCT07623161" }, { "nct_id": "NCT07672574", "title": "Human Mass Balance Study of [14C] Ontunisertib in Healthy Volunteers", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "Agomab Spain S.L.U.", "conditions": [ "Fibrostenotic Crohn's Disease" ], "sites": [ "Nottingham" ], "enrollment": 8, "start_date": "2026-09-09", "registry_url": "https://clinicaltrials.gov/study/NCT07672574" }, { "nct_id": "NCT07640984", "title": "A Phase I/II Trial of JR-446 in Mucopolysaccharidosis Type IIIB (MPS IIIB)", "status": "RECRUITING", "phase": "Phase 1/2", "lead_sponsor": "JCR Pharmaceuticals Co., Ltd.", "conditions": [ "Mucopolysaccharidosis IIIB" ], "sites": [ "London" ], "enrollment": 12, "start_date": "2026-09-09", "registry_url": "https://clinicaltrials.gov/study/NCT07640984" }, { "nct_id": "NCT07810010", "title": "Phase 2b Study of a Respiratory Syncytial Virus and Human Metapneumovirus (RSV+HMPV) Protein Vaccine Candidate in Adults 60 Years of Age and Older", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Sanofi", "conditions": [ "Respiratory Syncytial Virus", "Human Metapneumovirus", "Healthy Volunteers" ], "sites": [ "Cardiff", "Bournemouth", "Dorchester", "London", "Portsmouth", "Blackpool", "Corby", "Witney" ], "enrollment": 8000, "start_date": "2026-09-09", "registry_url": "https://clinicaltrials.gov/study/NCT07810010" }, { "nct_id": "NCT07665450", "title": "A Study of Ramantamig Plus Daratumumab Versus Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone (DVRd) or Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With NDMM For Whom Stem Cell Transplant is Not Planned", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Janssen Research & Development, LLC", "conditions": [ "Multiple Myeloma" ], "sites": [ "Blackpool", "Cambridge", "Canterbury" ], "enrollment": 1000, "start_date": "2026-09-09", "registry_url": "https://clinicaltrials.gov/study/NCT07665450" }, { "nct_id": "NCT07560020", "title": "A Trial to Compare Treatment With Surlorian (ARM210, S48168) to Placebo in Effects on Muscle Strength and Safety in Adults With Autosomal Dominant RYR1-related Myopathy", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "RyCarma Therapeutics, Inc.", "conditions": [ "Autosomal Dominant RYR1-Related Myopathy" ], "sites": [ "Oswestry", "London" ], "enrollment": 28, "start_date": "2026-09-09", "registry_url": "https://clinicaltrials.gov/study/NCT07560020" }, { "nct_id": "NCT07623200", "title": "A Phase 3 Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Incyte Corporation", "conditions": [ "Essential Thrombocythemia" ], "sites": [ "Cambridge", "Edinburgh", "Harrow", "Leeds", "London", "Newcastle upon Tyne", "Oxford", "Penzance" ], "enrollment": 426, "start_date": "2026-09-08", "registry_url": "https://clinicaltrials.gov/study/NCT07623200" }, { "nct_id": "NCT07747467", "title": "A Study to Investigate the Safety and Tolerability of Multiple Study Interventions in Participants With Moderate to Severe Ulcerative Colitis", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Colitis, Ulcerative" ], "sites": [ "Oxford" ], "enrollment": 8, "start_date": "2026-09-03", "registry_url": "https://clinicaltrials.gov/study/NCT07747467" }, { "nct_id": "NCT07783503", "title": "A Drug-drug Interaction Study to Assess the Effect of Phenytoin and Itraconazole on the Pharmacokinetics of Pelabresib in Healthy Participants", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Healthy Participants" ], "sites": [ "Nottingham" ], "enrollment": 30, "start_date": "2026-09-02", "registry_url": "https://clinicaltrials.gov/study/NCT07783503" }, { "nct_id": "NCT07746843", "title": "The Efficacy and Safety Study of 2107 Injection in Subjects With Mild to Moderate Knee Osteoarthritis", "status": "NOT_YET_RECRUITING", "phase": "Not applicable", "lead_sponsor": "BioRegen Biomedical (Changzhou) Co., Ltd", "conditions": [ "Mild Knee Osteoarthritis", "Moderate Knee Osteoarthritis" ], "sites": [ "Glasgow" ], "enrollment": 286, "start_date": "2026-09-01", "registry_url": "https://clinicaltrials.gov/study/NCT07746843" }, { "nct_id": "NCT07624305", "title": "A Phase III Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With CKD Stage 3b and 4 (BalanceD-CKD)", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "AstraZeneca", "conditions": [ "Renal Insufficiency, Chronic" ], "sites": [ "Aberdeen", "Bristol", "Cardiff", "Dundee", "Glasgow", "London", "Swansea" ], "enrollment": 2800, "start_date": "2026-09-01", "registry_url": "https://clinicaltrials.gov/study/NCT07624305" }, { "nct_id": "NCT07587242", "title": "A Phase 3 Study to Evaluate the Safety and Efficacy of AOC 1044 (Also Referred to as Delpacibart Zotadirsen) in Participants With DMD With Gene Mutations Amenable to Exon 44 Skipping", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Avidity Biosciences, Inc.", "conditions": [ "Muscular Dystrophies", "Muscular Dystrophies (Duchenne, Becker, Myotonic Dystrophy)", "Muscular Disorders, Atrophic", "Muscular Disease" ], "sites": [ "Newcastle", "Oxford" ], "enrollment": 70, "start_date": "2026-09-01", "registry_url": "https://clinicaltrials.gov/study/NCT07587242" }, { "nct_id": "NCT07438951", "title": "Efficacy and Safety of a Nitric Oxide Generating Dressing for Diabetic Foot Ulcers (ONWARD)", "status": "RECRUITING", "phase": "Observational", "lead_sponsor": "ConvaTec Inc.", "conditions": [ "Diabetic Foot Ulcers (DFUs)" ], "sites": [ "Ashton-under-Lyne" ], "enrollment": 102, "start_date": "2026-09-01", "registry_url": "https://clinicaltrials.gov/study/NCT07438951" }, { "nct_id": "NCT07645248", "title": "A Study to Compare Safety of 4 Weeks Exposure to Propellants Hydrofluoroalkane 1,1-difluoroethane (HFA-152a) and HFA-1,1,1,2-tetrafluoroethane (134a)", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Asthma" ], "sites": [ "Great Cambourne", "Greater Manchester" ], "enrollment": 110, "start_date": "2026-09-01", "registry_url": "https://clinicaltrials.gov/study/NCT07645248" }, { "nct_id": "NCT07654283", "title": "Study of AHB-137 in Chronic Hepatitis B (CHB) Participants in North America and Europe Regions", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "AusperBio Therapeutics Inc.", "conditions": [ "Hepatitis B, Chronic" ], "sites": [ "London" ], "enrollment": 70, "start_date": "2026-09-01", "registry_url": "https://clinicaltrials.gov/study/NCT07654283" }, { "nct_id": "NCT07654855", "title": "Long-term Safety of Eplontersen Treated aTTR Patients and in Liver Transplant and Severely Hepatic Impaired Subpopulations", "status": "RECRUITING", "phase": "Observational", "lead_sponsor": "AstraZeneca", "conditions": [ "Transthyretin Amyloidosis", "Transthyretin Amyloidosis With Cardiomyopathy", "Transthyretin Amyloidosis With Polyneuropathy" ], "sites": [ "Birmingham" ], "enrollment": 320, "start_date": "2026-09-01", "registry_url": "https://clinicaltrials.gov/study/NCT07654855" }, { "nct_id": "NCT07802886", "title": "A Clinical Study to Assess the Efficacy of a Calcium Sodium Phosphosilicate Toothpaste for the Relief of Dentine Hypersensitivity", "status": "NOT_YET_RECRUITING", "phase": "Not applicable", "lead_sponsor": "HALEON", "conditions": [ "Dentin Sensitivity" ], "sites": [ "Bristol" ], "enrollment": 192, "start_date": "2026-09", "registry_url": "https://clinicaltrials.gov/study/NCT07802886" }, { "nct_id": "NCT07752342", "title": "Exploring Wellbeing Outcomes in Adolescents Using Bifidobacterium Longum, 1714\u2122", "status": "NOT_YET_RECRUITING", "phase": "Not applicable", "lead_sponsor": "Novonesis", "conditions": [ "Healthy Young Adults" ], "sites": [ "Cardiff" ], "enrollment": 150, "start_date": "2026-09", "registry_url": "https://clinicaltrials.gov/study/NCT07752342" }, { "nct_id": "NCT07719309", "title": "Exploratory Study of Peristomal and Non-Peristomal Skin Barrier Characteristics in People With a Stoma", "status": "RECRUITING", "phase": "Observational", "lead_sponsor": "Salts Healthcare", "conditions": [ "Colostomy - Stoma", "Ileostomy - Stoma", "Urostomy" ], "sites": [ "Birmingham" ], "enrollment": 108, "start_date": "2026-09", "registry_url": "https://clinicaltrials.gov/study/NCT07719309" }, { "nct_id": "NCT07665515", "title": "Study of CryptiVax-1001 in Maintenance Setting for Advanced Serous Ovarian, Fallopian Tube, or Primary Peritoneal Cancer", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "Epitopea Ltd", "conditions": [ "Ovarian Cancer", "HGSOC", "HGS Ovarian, Fallopian Tube or Primary Peritoneal Cancer" ], "sites": [ "Cambridge", "Edinburgh", "Glasgow", "Leeds", "Leicester", "London", "Preston", "Sutton" ], "enrollment": 50, "start_date": "2026-09", "registry_url": "https://clinicaltrials.gov/study/NCT07665515" }, { "nct_id": "NCT07859917", "title": "Study in Young Adults to Understand How Glasses With a Small Reading Addition Affect Focusing and Eye Coordination During Vision Tasks", "status": "NOT_YET_RECRUITING", "phase": "Not applicable", "lead_sponsor": "Essilor International", "conditions": [ "Healthy Young Adults", "Accommodation Disorder" ], "sites": [ "London" ], "enrollment": 96, "start_date": "2026-09", "registry_url": "https://clinicaltrials.gov/study/NCT07859917" }, { "nct_id": "NCT07845721", "title": "Using Contact Lenses and Spectacle Lenses as Myopia Interventions.", "status": "NOT_YET_RECRUITING", "phase": "Not applicable", "lead_sponsor": "CooperVision International Limited (CVIL)", "conditions": [ "Myopia" ], "sites": [ "Birmingham" ], "enrollment": 58, "start_date": "2026-09", "registry_url": "https://clinicaltrials.gov/study/NCT07845721" }, { "nct_id": "NCT07691970", "title": "Rollover Study for Participants Who Have Completed a Previous Clinical Study With Anifrolumab (Saphnelo) and Clinically Benefited From Continued Treatment", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "AstraZeneca", "conditions": [ "Systemic Sclerosis Cutaneous Lupus E Myopathies Systemic Lupus Erythematosus" ], "sites": [ "Cambridge", "Leeds", "London", "Newcastle upon Tyne", "Sheffield" ], "enrollment": 1072, "start_date": "2026-08-31", "registry_url": "https://clinicaltrials.gov/study/NCT07691970" }, { "nct_id": "NCT07743463", "title": "A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Ascletis Pharma (China) Co., Limited", "conditions": [ "Obesity", "Overweight", "Chronic Weight Management" ], "sites": [ "Bellshill", "Cardiff", "Edgbaston", "London", "Manchester", "Stoke-on-Trent", "Warrington" ], "enrollment": 3003, "start_date": "2026-08-31", "registry_url": "https://clinicaltrials.gov/study/NCT07743463" }, { "nct_id": "NCT07781345", "title": "A Postmarketing Study of LEQEMBI in United Kingdom (UK) Participants With Alzheimer's Disease (AD)", "status": "NOT_YET_RECRUITING", "phase": "Observational", "lead_sponsor": "Eisai Limited", "conditions": [ "Alzheimers Disease" ], "sites": [ "Edinburgh", "London", "Motherwell" ], "enrollment": 400, "start_date": "2026-08-31", "registry_url": "https://clinicaltrials.gov/study/NCT07781345" }, { "nct_id": "NCT07603557", "title": "Study of Zola-cel (BMS-986353), in Participants With Autoimmune Cytopenia (Breakfree-AiCE)", "status": "NOT_YET_RECRUITING", "phase": "Phase 2", "lead_sponsor": "Juno Therapeutics, Inc., a Bristol-Myers Squibb Company", "conditions": [ "Chronic Immune Thrombocytopenia", "Autoimmune Hemolytic Anemia" ], "sites": [ "London", "Sheffield" ], "enrollment": 52, "start_date": "2026-08-31", "registry_url": "https://clinicaltrials.gov/study/NCT07603557" }, { "nct_id": "NCT07743450", "title": "A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Ascletis Pharma (China) Co., Limited", "conditions": [ "Obesity", "Overweight", "Chronic Weight Management", "Type 2 Diabetes Mellitus" ], "sites": [ "Cardiff", "Edgbaston", "Glasgow", "London", "Manchester", "Stoke-on-Trent", "Warrington" ], "enrollment": 1560, "start_date": "2026-08-28", "registry_url": "https://clinicaltrials.gov/study/NCT07743450" }, { "nct_id": "NCT07761351", "title": "A Randomized Controlled Trial Comparing Percutaneous CT-Guided Biopsy and Shape-Sensing Robotic-Assisted Bronchoscopy", "status": "RECRUITING", "phase": "Phase 4", "lead_sponsor": "Intuitive Surgical", "conditions": [ "Lung Cancer (Diagnosis)", "Lung Nodule" ], "sites": [ "London" ], "enrollment": 550, "start_date": "2026-08-28", "registry_url": "https://clinicaltrials.gov/study/NCT07761351" }, { "nct_id": "NCT07705555", "title": "A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-004)", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Diabetic Retinopathy", "Macular Edema" ], "sites": [ "Bristol" ], "enrollment": 960, "start_date": "2026-08-27", "registry_url": "https://clinicaltrials.gov/study/NCT07705555" }, { "nct_id": "NCT07771465", "title": "A Study of the Long-term Safety and Efficacy of Danicamtiv in Adults With Symptomatic Genetic and Familial Dilated Cardiomyopathy", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Kardigan, Inc.", "conditions": [ "Symptomatic Genetic Dilated Cardiomyopathy (DCM)" ], "sites": [ "Bristol", "Glasgow", "Leicester", "London", "Oxford" ], "enrollment": 332, "start_date": "2026-08-26", "registry_url": "https://clinicaltrials.gov/study/NCT07771465" }, { "nct_id": "NCT07761117", "title": "A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "AstraZeneca", "conditions": [ "Heart Failure With Preserved Ejection Fraction (HFpEF)", "Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)" ], "sites": [ "Ashton-under-Lyne", "Basildon", "Belfast", "Birmingham", "Brighton", "Bristol", "Cardiff", "Clydebank" ], "enrollment": 6950, "start_date": "2026-08-24", "registry_url": "https://clinicaltrials.gov/study/NCT07761117" }, { "nct_id": "NCT07797335", "title": "AMBITION 7: A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Insulin Glargine in People With Type 2 Diabetes and Increased Risk of Diseases That Affect the Heart and Blood Vessels Treated With 1-3 Other Diabetes Medications", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Type 2 Diabetes", "Cardiovascular Risk" ], "sites": [ "Newquay", "Yeovil", "Rotherham", "Bristol", "Coventry", "Hull", "Ipswich", "Londonderry" ], "enrollment": 1778, "start_date": "2026-08-24", "registry_url": "https://clinicaltrials.gov/study/NCT07797335" }, { "nct_id": "NCT07776509", "title": "A Study to Evaluate Effect of AZD6234 as an Adjunct to Incretin-based Therapies in Adult Participants With Obesity or Overweight With Weight-related Comorbidity With or Without Type 2 Diabetes Mellitus", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "AstraZeneca", "conditions": [ "Obesity or Overweight", "Weight-Related Comorbidity", "With/Without Diabetes Mellitus, Type 2" ], "sites": [ "Airdrie", "Chippenham", "Hull", "Llandough", "Rotherham" ], "enrollment": 500, "start_date": "2026-08-24", "registry_url": "https://clinicaltrials.gov/study/NCT07776509" }, { "nct_id": "NCT07753993", "title": "A Study to Investigate Outcomes With Elecoglipron Compared With Placebo in Adult Participants With Chronic Kidney Disease.", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "AstraZeneca", "conditions": [ "Chronic Kidney Disease" ], "sites": [ "Aberdeen", "Cardiff", "Corby", "Coventry", "Dundee", "Glasgow", "Leicester", "Liverpool" ], "enrollment": 7000, "start_date": "2026-08-21", "registry_url": "https://clinicaltrials.gov/study/NCT07753993" }, { "nct_id": "NCT07784270", "title": "A Study to Evaluate Effect of AZD6234 in Adult Participants With Type 2 Diabetes Mellitus and Obesity or Overweight", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "AstraZeneca", "conditions": [ "Obesity or Overweight", "Diabetes Mellitus, Type 2" ], "sites": [ "Chippenham", "Corby", "Dunfermline", "Hull", "Northwood" ], "enrollment": 1500, "start_date": "2026-08-20", "registry_url": "https://clinicaltrials.gov/study/NCT07784270" }, { "nct_id": "NCT07356973", "title": "Irinotecan-ChemoSeed in Surgically Resectable Glioblastoma", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "CRISM Therapeutics LTD", "conditions": [ "Glioblastoma" ], "sites": [ "Birmingham" ], "enrollment": 147, "start_date": "2026-08-20", "registry_url": "https://clinicaltrials.gov/study/NCT07356973" }, { "nct_id": "NCT07674667", "title": "FUNCtion ALS: Aiming to Restore UNC13A Function in People Living With ALS", "status": "RECRUITING", "phase": "Phase 1/2", "lead_sponsor": "Trace Neuroscience, Inc.", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "sites": [ "London", "Sheffield" ], "enrollment": 30, "start_date": "2026-08-20", "registry_url": "https://clinicaltrials.gov/study/NCT07674667" }, { "nct_id": "NCT07143448", "title": "A Study of HS235 for Treatment of Pulmonary Arterial Hypertension (PAH) in Adults", "status": "RECRUITING", "phase": "Phase 1/2", "lead_sponsor": "35Pharma Inc., a GSK company", "conditions": [ "Pulmonary Arterial Hypertension" ], "sites": [ "London" ], "enrollment": 90, "start_date": "2026-08-19", "registry_url": "https://clinicaltrials.gov/study/NCT07143448" }, { "nct_id": "NCT07288489", "title": "Phase 3 Trial of Reltodecacog Alfa (VMX-C001) vs Usual Pharmacological Care in Patients Taking a FXa Direct Oral Anticoagulant Who Require Urgent Surgery With or Without Heparin.", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "VarmX B.V.", "conditions": [ "Blood Loss, Surgical", "Coagulation Disorder" ], "sites": [ "Gloucester", "London", "Birmingham", "Edinburgh" ], "enrollment": 800, "start_date": "2026-08-18", "registry_url": "https://clinicaltrials.gov/study/NCT07288489" }, { "nct_id": "NCT07789899", "title": "A Study to Evaluate Pharmacokinetics, Safety, and Tolerability of Two GSK3862995B Formulations in Healthy Participants", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Pulmonary Disease, Chronic Obstructive" ], "sites": [ "Cambridge" ], "enrollment": 24, "start_date": "2026-08-18", "registry_url": "https://clinicaltrials.gov/study/NCT07789899" }, { "nct_id": "NCT07298421", "title": "A Study to Assess the Pharmacokinetics, Effectiveness and Safety of Afimkibart for Induction and Maintenance Therapy in Children With Moderately to Severely Active Crohn's Disease", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Moderately to Severely Active Crohns Disease" ], "sites": [ "London", "Sheffield" ], "enrollment": 100, "start_date": "2026-08-18", "registry_url": "https://clinicaltrials.gov/study/NCT07298421" }, { "nct_id": "NCT07221292", "title": "Pivotal Study of N-acetyl-L-leucine for CACNA1A", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "IntraBio Inc", "conditions": [ "CACNA1A", "Spinocerebellar Ataxia Type 6", "Episodic Ataxia Type 2", "Familial Hemiplegic Migraine-1" ], "sites": [ "Newcastle upon Tyne", "Oxford" ], "enrollment": 60, "start_date": "2026-08-17", "registry_url": "https://clinicaltrials.gov/study/NCT07221292" }, { "nct_id": "NCT07775300", "title": "A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Depressive Disorder, Major" ], "sites": [ "Bodmin", "Edinburgh", "Exeter", "Glasgow", "Liverpool", "Motherwell", "Oxford", "Penzance" ], "enrollment": 1000, "start_date": "2026-08-14", "registry_url": "https://clinicaltrials.gov/study/NCT07775300" }, { "nct_id": "NCT07403968", "title": "A Study of Zasocitinib (TAK-279) in Adults With Active Crohn's Disease", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Takeda", "conditions": [ "Crohn's Disease" ], "sites": [ "Oxford" ], "enrollment": 20, "start_date": "2026-08-13", "registry_url": "https://clinicaltrials.gov/study/NCT07403968" }, { "nct_id": "NCT07432880", "title": "A Prospective Study of Pediatric Participants up to 16 Years of Age With Methylmalonic Acidemia (MMA) Due to Mutations in the MMUT Gene", "status": "RECRUITING", "phase": "Observational", "lead_sponsor": "Genespire Srl", "conditions": [ "Methylmalonic Acidemia (MMA)" ], "sites": [ "London", "Manchester" ], "enrollment": 30, "start_date": "2026-08-13", "registry_url": "https://clinicaltrials.gov/study/NCT07432880" }, { "nct_id": "NCT07619131", "title": "A Phase III Study to Assess the Effect of FDC Laroprovstat/Rosuvastatin Compared With Laroprovstat, Rosuvastatin and Placebo on LDL-C in LLT-na\u00efve Patients.", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "AstraZeneca", "conditions": [ "Hypercholesterolaemia" ], "sites": [ "Coventry", "Knutsford", "London", "Orpington", "Poole", "Shipley" ], "enrollment": 600, "start_date": "2026-08-12", "registry_url": "https://clinicaltrials.gov/study/NCT07619131" }, { "nct_id": "NCT07764237", "title": "A Study to Investigate Safety, Reactogenicity, and Immunogenicity of mRNA-1365 (Profile 2) in Older Healthy Adults", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "ModernaTX, Inc.", "conditions": [ "Respiratory Syncytial Virus (RSV)", "Human Metapneuomovirus (hMPV)" ], "sites": [ "Manchester", "Southampton", "Norwich", "Birmingham", "London", "Newcastle" ], "enrollment": 375, "start_date": "2026-08-11", "registry_url": "https://clinicaltrials.gov/study/NCT07764237" }, { "nct_id": "NCT07759245", "title": "A Study of Brenipatide (LY3537031) in Adult Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Pulmonary Disease, Chronic Obstructive" ], "sites": [ "Cheadle", "Ely", "Hounslow", "London", "Penzance", "West Kirby" ], "enrollment": 606, "start_date": "2026-08-07", "registry_url": "https://clinicaltrials.gov/study/NCT07759245" }, { "nct_id": "NCT07758595", "title": "A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of DNL921 in Healthy Participants and Participants With Alzheimer's Disease", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "Denali Therapeutics Inc.", "conditions": [ "Alzheimer's Disease", "Healthy Participants" ], "sites": [ "Manchester" ], "enrollment": 178, "start_date": "2026-08-07", "registry_url": "https://clinicaltrials.gov/study/NCT07758595" }, { "nct_id": "NCT07746895", "title": "Real-World Effectiveness and Safety of Pegcetacoplan in Patients With C3G or IC-MPG: A Multi-Country Study", "status": "RECRUITING", "phase": "Phase 4", "lead_sponsor": "Swedish Orphan Biovitrum", "conditions": [ "C3 Glomerulopathy (C3G)", "Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN)" ], "sites": [ "Cambridge", "Cardiff", "Glasgow", "Leicester", "London", "Manchester", "Newcastle", "Salford" ], "enrollment": 150, "start_date": "2026-08-05", "registry_url": "https://clinicaltrials.gov/study/NCT07746895" }, { "nct_id": "NCT06593392", "title": "Safety and Tolerability of Difelikefalin in Adolescents on Haemodialysis With Moderate-to-Severe Pruritus", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Vifor Fresenius Medical Care Renal Pharma", "conditions": [ "Pruritus", "Chronic Kidney Diseases" ], "sites": [ "Glasgow", "Liverpool" ], "enrollment": 18, "start_date": "2026-08-04", "registry_url": "https://clinicaltrials.gov/study/NCT06593392" }, { "nct_id": "NCT07227896", "title": "Real-World Study of Foslevodopa/Foscarbidopa to Assess Quality of Life Outcomes in Adult Participants Earlier Within Advanced Parkinson Disease", "status": "RECRUITING", "phase": "Observational", "lead_sponsor": "AbbVie", "conditions": [ "Parkinson's Disease" ], "sites": [ "Plymouth" ], "enrollment": 100, "start_date": "2026-08-03", "registry_url": "https://clinicaltrials.gov/study/NCT07227896" }, { "nct_id": "NCT07357675", "title": "A Clinical Trial To Investigate The Effect Of EA-230 On Hospital Length Of Stay In Patients With Coronary Artery Disease (CAD) Undergoing Coronary Artery Bypass Grafting (CABG) Surgery.", "status": "NOT_YET_RECRUITING", "phase": "Phase 3", "lead_sponsor": "EBI Anti Sepsis BV", "conditions": [ "Coronary Artery Disease (CAD)", "Coronary Artery Bypass Graft Surgery(CABG)" ], "sites": [ "London" ], "enrollment": 300, "start_date": "2026-08-01", "registry_url": "https://clinicaltrials.gov/study/NCT07357675" }, { "nct_id": "NCT07682129", "title": "Long-Term Extension Study in Participants With Duchenne Muscular Dystrophy Amenable to Exon Skipping to Evaluate the Safety and Efficacy of Endosomal Escape Vehicle Phosphorodiamidate Morpholino Oligomer Platform Products (ELEVATE-LTE)", "status": "NOT_YET_RECRUITING", "phase": "Phase 2", "lead_sponsor": "Entrada Therapeutics, Inc.", "conditions": [ "Duchenne Muscular Dystrophy (DMD)" ], "sites": [ "Leeds", "Liverpool", "London", "Manchester", "Newcastle upon Tyne", "Oxford" ], "enrollment": 80, "start_date": "2026-08", "registry_url": "https://clinicaltrials.gov/study/NCT07682129" }, { "nct_id": "NCT07742735", "title": "A Study to Investigate the Efficacy and Safety of Apraglutide Compared With Placebo in Adult Participants With Short Bowel Syndrome Associated With Intestinal Failure (SBS-IF)", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "VectivBio AG", "conditions": [ "Short Bowel Syndrome (SBS)", "SBS Associated With Intestinal Failure (SBS-IF)" ], "sites": [ "London", "Aberdeen", "Birmingham", "Salford" ], "enrollment": 124, "start_date": "2026-08", "registry_url": "https://clinicaltrials.gov/study/NCT07742735" }, { "nct_id": "NCT07685600", "title": "Investigating the Effect of Itraconazole on the Pharmacokinetics of AZD4144 in Healthy Participants", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "AstraZeneca", "conditions": [ "Healthy" ], "sites": [ "Harrow" ], "enrollment": 32, "start_date": "2026-07-30", "registry_url": "https://clinicaltrials.gov/study/NCT07685600" }, { "nct_id": "NCT07575308", "title": "HMBeacon: A Phase 2 Study to Evaluate ALN-6400 in Adult and Adolescent Female Patients With VWD and HMB", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Alnylam Pharmaceuticals", "conditions": [ "Von Willebrand Disease (VWD)", "Heavy Menstrual Bleeding (HMB)" ], "sites": [ "Birmingham", "Bradford", "London", "Oxford", "Truro" ], "enrollment": 24, "start_date": "2026-07-30", "registry_url": "https://clinicaltrials.gov/study/NCT07575308" }, { "nct_id": "NCT07684144", "title": "Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-2-EXTENSION)", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Amgen", "conditions": [ "Obesity", "Overweight", "Diabetes Mellitus, Type 2" ], "sites": [ "Birmingham" ], "enrollment": 950, "start_date": "2026-07-29", "registry_url": "https://clinicaltrials.gov/study/NCT07684144" }, { "nct_id": "NCT07688213", "title": "A Study to Investigate the Safety and Effectiveness of SAR448851 in Participants With Early Alzheimer's Disease", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Sanofi", "conditions": [ "Dementia, Alzheimer's Type", "Alzheimer's Disease" ], "sites": [ "London", "Bath" ], "enrollment": 160, "start_date": "2026-07-28", "registry_url": "https://clinicaltrials.gov/study/NCT07688213" }, { "nct_id": "NCT07585266", "title": "A Study to Investigate Velzatinib Compared With Imatinib in Adult Participants With Previously Untreated Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (StrateGIST Frontline)", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Gastrointestinal Stromal Neoplasms" ], "sites": [ "Manchester", "London", "Newcastle upon Tyne", "Sheffield" ], "enrollment": 800, "start_date": "2026-07-27", "registry_url": "https://clinicaltrials.gov/study/NCT07585266" }, { "nct_id": "NCT07646353", "title": "First-in-Human Dose-escalation of GSK4425689A: Safety, Tolerability, and PK in Healthy Adults", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Malaria, Falciparum" ], "sites": [ "Manchester" ], "enrollment": 40, "start_date": "2026-07-27", "registry_url": "https://clinicaltrials.gov/study/NCT07646353" }, { "nct_id": "NCT07497087", "title": "A Study to Test Whether Nerandomilast Helps People With Systemic Sclerosis", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Systemic Sclerosis" ], "sites": [ "Bristol", "Leeds", "London", "Salford" ], "enrollment": 448, "start_date": "2026-07-27", "registry_url": "https://clinicaltrials.gov/study/NCT07497087" }, { "nct_id": "NCT07444567", "title": "Roll-over Study for Participants Who Have Completed a Previous Clinical Study With Benralizumab (Fasenra) and Benefit From Continued Treatment", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "AstraZeneca", "conditions": [ "Asthma", "Eosinophilic Granulomatosis With Polyangiitis (EGPA)", "Hypereosinophilic Syndrome (HES)" ], "sites": [ "London" ], "enrollment": 230, "start_date": "2026-07-24", "registry_url": "https://clinicaltrials.gov/study/NCT07444567" }, { "nct_id": "NCT07130136", "title": "Post-market Evaluation of the Transition From the Baha Connect System to the Osia System in Adult Bone Conduction Implant Recipients", "status": "RECRUITING", "phase": "Not applicable", "lead_sponsor": "Cochlear", "conditions": [ "Bone Conduction", "Hearing Loss, Conductive", "Hearing Loss, Mixed" ], "sites": [ "London", "Nottingham", "Sheffield" ], "enrollment": 20, "start_date": "2026-07-24", "registry_url": "https://clinicaltrials.gov/study/NCT07130136" }, { "nct_id": "NCT06951880", "title": "A Study to Investigate the Safety and Pharmacokinetics of Single- and Multiple-ascending Doses of AZD4916 in Healthy Volunteers", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "AstraZeneca", "conditions": [ "Healthy Participants" ], "sites": [ "Harrow" ], "enrollment": 160, "start_date": "2026-07-23", "registry_url": "https://clinicaltrials.gov/study/NCT06951880" }, { "nct_id": "NCT06987539", "title": "A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Inebilizumab in Children With Generalized Myasthenia Gravis (gMG)", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Amgen", "conditions": [ "Generalized Myasthenia Gravis" ], "sites": [ "Oxford" ], "enrollment": 15, "start_date": "2026-07-21", "registry_url": "https://clinicaltrials.gov/study/NCT06987539" }, { "nct_id": "NCT07366034", "title": "A Study to Find Out How Nerandomilast is Tolerated, Handled by the Body, and if it Helps Children and Adolescents With Interstitial Lung Disease (FIBRONEER-chILD)", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Fibrosing Interstitial Lung Disease" ], "sites": [ "Birmingham", "London" ], "enrollment": 35, "start_date": "2026-07-21", "registry_url": "https://clinicaltrials.gov/study/NCT07366034" }, { "nct_id": "NCT06162195", "title": "The ACTIVE Trial: A Prospective Randomised Control Trial Of The H1 Implant Versus Total Hip Replacement", "status": "RECRUITING", "phase": "Not applicable", "lead_sponsor": "Embody Orthopaedic Limited", "conditions": [ "Osteoarthritis, Hip", "Inflammatory Arthritis" ], "sites": [ "Bournemouth", "Coventry", "Truro" ], "enrollment": 200, "start_date": "2026-07-21", "registry_url": "https://clinicaltrials.gov/study/NCT06162195" }, { "nct_id": "NCT07807241", "title": "A Study of MX006 in Patients With Advanced and/or Metastatic Tumors Known to Express B7-H3", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "Myricx Pharma Limited", "conditions": [ "Advanced and/or Metastatic Solid Tumors Known to Express B7-H3" ], "sites": [ "Sutton" ], "enrollment": 120, "start_date": "2026-07-20", "registry_url": "https://clinicaltrials.gov/study/NCT07807241" }, { "nct_id": "NCT07720284", "title": "An Open-label Study to Investigate the Efficacy and Safety of Dato-DXd + Rilvegostomig vs SoC in Adult Participants With High-risk MIUC", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "AstraZeneca", "conditions": [ "High-risk Muscle Invasive Urothelial Carcinoma" ], "sites": [ "Bristol", "Cambridge", "Preston", "Sheffield" ], "enrollment": 915, "start_date": "2026-07-16", "registry_url": "https://clinicaltrials.gov/study/NCT07720284" }, { "nct_id": "NCT07690059", "title": "A Study to Investigate the Efficacy and Safety of SC0032, a Magnesium Salt Oral Spray, in Adults With Refractory or Unexplained Chronic Cough", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Sensory Cloud, Inc.", "conditions": [ "Refractory Chronic Cough and Unexplained Chronic Cough" ], "sites": [ "Belfast", "London" ], "enrollment": 60, "start_date": "2026-07-13", "registry_url": "https://clinicaltrials.gov/study/NCT07690059" }, { "nct_id": "NCT07471295", "title": "Toric Performance And Constant Evaluation", "status": "RECRUITING", "phase": "Phase 4", "lead_sponsor": "Carl Zeiss Meditec AG", "conditions": [ "Cataract" ], "sites": [ "Ayr" ], "enrollment": 130, "start_date": "2026-07-13", "registry_url": "https://clinicaltrials.gov/study/NCT07471295" }, { "nct_id": "NCT07318610", "title": "Reducing Adverse Vascular Outcomes With Factor XI Inhibition in Adult Participants With Peripheral Artery Disease", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Regeneron Pharmaceuticals", "conditions": [ "Peripheral Artery Disease (PAD)" ], "sites": [ "Doncaster", "London" ], "enrollment": 7050, "start_date": "2026-07-10", "registry_url": "https://clinicaltrials.gov/study/NCT07318610" }, { "nct_id": "NCT07544654", "title": "DAREON\u00ae-NEC-1: A Study in People With Advanced Extrapulmonary Neuroendocrine Cancer (epNEC) to Compare Obrixtamig Plus Carboplatin and Etoposide Treatment With Standard Chemotherapy", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Extrapulmonary Neuroendocrine Cancer (epNEC)" ], "sites": [ "Cambridge", "Edinburgh", "Manchester" ], "enrollment": 390, "start_date": "2026-07-10", "registry_url": "https://clinicaltrials.gov/study/NCT07544654" }, { "nct_id": "NCT07516951", "title": "A Study to Find an Efficacious and Safe Dose of CHF10067 (Zampilimab) in Participants With Idiopathic Pulmonary Fibrosis", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Chiesi Farmaceutici S.p.A.", "conditions": [ "Idiopathic Pulmonary Fibrosis" ], "sites": [ "Cambridge", "Exeter" ], "enrollment": 240, "start_date": "2026-07-08", "registry_url": "https://clinicaltrials.gov/study/NCT07516951" }, { "nct_id": "NCT07668336", "title": "A Study of Orforglipron (LY3502970) Compared With Dulaglutide in Pediatric Participants With Type 2 Diabetes", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Diabetes Mellitus, Type 2" ], "sites": [ "Hull", "Liverpool", "London" ], "enrollment": 170, "start_date": "2026-07-08", "registry_url": "https://clinicaltrials.gov/study/NCT07668336" }, { "nct_id": "NCT07498725", "title": "A Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of LRK-4189 Alone and in Combination in Patients With Solid Tumors", "status": "RECRUITING", "phase": "Phase 1/2", "lead_sponsor": "LARKSPUR BIOSCIENCES, INC.", "conditions": [ "Neoplasms" ], "sites": [ "Edinburgh" ], "enrollment": 120, "start_date": "2026-07-07", "registry_url": "https://clinicaltrials.gov/study/NCT07498725" }, { "nct_id": "NCT07662135", "title": "A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "AstraZeneca", "conditions": [ "Type 2 Diabetes Mellitus", "Type 2 Diabetes With Chronic Kidney Disease" ], "sites": [ "Blackpool", "Glasgow", "Hull", "Penzance", "Sandbach", "Thetford", "Whitney" ], "enrollment": 900, "start_date": "2026-07-06", "registry_url": "https://clinicaltrials.gov/study/NCT07662135" }, { "nct_id": "NCT07662213", "title": "A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "AstraZeneca", "conditions": [ "Type 2 Diabetes Mellitus" ], "sites": [ "Aberdeen", "Addlestone", "Banbury", "Bristol", "Edinburgh", "Hounslow", "Penzance", "Poole" ], "enrollment": 1200, "start_date": "2026-07-06", "registry_url": "https://clinicaltrials.gov/study/NCT07662213" }, { "nct_id": "NCT07730359", "title": "Clinical Investigation of the Performance of Epinamel for Dental White Spot Lesions", "status": "RECRUITING", "phase": "Not applicable", "lead_sponsor": "Mintech Bio Ltd", "conditions": [ "White Spot Lesions [Initial Caries] on Smooth Surface of Tooth" ], "sites": [ "London" ], "enrollment": 20, "start_date": "2026-07-06", "registry_url": "https://clinicaltrials.gov/study/NCT07730359" }, { "nct_id": "NCT07662109", "title": "A Phase III Study to Investigate the Efficacy and Safety of the Combination of Elecoglipron and Dapagliflozin in Adults With Type 2 Diabetes Mellitus", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "AstraZeneca", "conditions": [ "Type 2 Diabetes Mellitus" ], "sites": [ "Blackburn", "Dundee", "Guisborough", "Nantwich", "Rotherham", "Thetford", "Weston-super-Mare", "Witney" ], "enrollment": 2000, "start_date": "2026-07-06", "registry_url": "https://clinicaltrials.gov/study/NCT07662109" }, { "nct_id": "NCT07531251", "title": "Clinical Trial in Patients With Barth Syndrome- 4TAZPower", "status": "RECRUITING", "phase": "Phase 4", "lead_sponsor": "Stealth BioTherapeutics Inc.", "conditions": [ "Barth Syndrome" ], "sites": [ "Bristol" ], "enrollment": 48, "start_date": "2026-07-02", "registry_url": "https://clinicaltrials.gov/study/NCT07531251" }, { "nct_id": "NCT07499258", "title": "Axonics R20 Post-Market Clinical Follow-up (PMCF) Study for the Indication of Fecal Incontinence", "status": "RECRUITING", "phase": "Observational", "lead_sponsor": "Axonics, Inc.", "conditions": [ "Fecal Incontinence" ], "sites": [ "Sheffield" ], "enrollment": 55, "start_date": "2026-07-02", "registry_url": "https://clinicaltrials.gov/study/NCT07499258" }, { "nct_id": "NCT07609108", "title": "Pridopidine Phase 3 Study in Huntington's Disease", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Prilenia", "conditions": [ "Huntington Disease" ], "sites": [ "Aberdeen", "Birmingham", "Cardiff", "Liverpool", "Newcastle upon Tyne" ], "enrollment": 400, "start_date": "2026-07-01", "registry_url": "https://clinicaltrials.gov/study/NCT07609108" }, { "nct_id": "NCT07453888", "title": "Efficacy and Safety of Intranasal Cenegermin in Adult Participants With Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Domp\u00e9 Farmaceutici S.p.A", "conditions": [ "Non-Arteritic Anterior Ischemic Optic Neuropathy" ], "sites": [ "London", "Manchester", "Abingdon", "York", "Bristol", "Liverpool" ], "enrollment": 272, "start_date": "2026-07-01", "registry_url": "https://clinicaltrials.gov/study/NCT07453888" }, { "nct_id": "NCT07638085", "title": "Exploring and Validating Biomarkers in Menstrual Blood", "status": "NOT_YET_RECRUITING", "phase": "Observational", "lead_sponsor": "Genie Fertility Ltd", "conditions": [ "Fertility" ], "sites": [ "London" ], "enrollment": 100, "start_date": "2026-07-01", "registry_url": "https://clinicaltrials.gov/study/NCT07638085" }, { "nct_id": "NCT07309809", "title": "Portrait Mobile Monitoring Solution V2.0 External Evaluation", "status": "NOT_YET_RECRUITING", "phase": "Not applicable", "lead_sponsor": "GE Healthcare", "conditions": [ "Monitoring" ], "sites": [ "London" ], "enrollment": 50, "start_date": "2026-07", "registry_url": "https://clinicaltrials.gov/study/NCT07309809" }, { "nct_id": "NCT07460323", "title": "Study of TRE Seals on Early Post-operative Subjects", "status": "RECRUITING", "phase": "Not applicable", "lead_sponsor": "Hollister Incorporated", "conditions": [ "Ostomy" ], "sites": [ "Stockton-on-Tees", "Saint Leonards-on-Sea", "Ashford", "Margate", "Redhill", "Coventry" ], "enrollment": 107, "start_date": "2026-06-30", "registry_url": "https://clinicaltrials.gov/study/NCT07460323" }, { "nct_id": "NCT07662122", "title": "A Study to Test Whether BI 3034701 Helps People to Lose Weight Who Live With Obesity or Overweight", "status": "ACTIVE_NOT_RECRUITING", "phase": "Phase 2", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Obesity", "Overweight" ], "sites": [ "Blackpool", "Guisborough", "High Wycombe", "Leicester", "Middlesbrough", "Oxford" ], "enrollment": 344, "start_date": "2026-06-30", "registry_url": "https://clinicaltrials.gov/study/NCT07662122" }, { "nct_id": "NCT07643870", "title": "Human ADME Study of [14C]-AZD1390", "status": "NOT_YET_RECRUITING", "phase": "Phase 1", "lead_sponsor": "AstraZeneca", "conditions": [ "Advanced Solid Malignancies" ], "sites": [ "Guildford", "Liverpool" ], "enrollment": 8, "start_date": "2026-06-30", "registry_url": "https://clinicaltrials.gov/study/NCT07643870" }, { "nct_id": "NCT07523581", "title": "EXACT Study: A Blinded Study in Patients With Alport Syndrome to Evaluate Exaluren Efficacy and Safety", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Eloxx Pharmaceuticals, Inc.", "conditions": [ "Alport Syndrome, X-Linked", "Alport Syndrome, Autosomal Recessive" ], "sites": [ "Liverpool", "London", "Manchester" ], "enrollment": 24, "start_date": "2026-06-30", "registry_url": "https://clinicaltrials.gov/study/NCT07523581" }, { "nct_id": "NCT07665723", "title": "An Early-Stage Study in Multiple Clinics of How Afimkibart May Affect the Body's Processing of Medicines That Rely on Cytochrome P450 Enzymes in Participants With Ulcerative Colitis", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Active Ulcerative Colitis" ], "sites": [ "Liverpool", "London", "Newcastle upon Tyne" ], "enrollment": 25, "start_date": "2026-06-29", "registry_url": "https://clinicaltrials.gov/study/NCT07665723" }, { "nct_id": "NCT07667803", "title": "A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "AstraZeneca", "conditions": [ "Weight Management" ], "sites": [ "Ashton-under-Lyne", "Blackpool", "Chesterfield", "Corby", "Ely", "Glasgow", "Hounslow", "Leicester" ], "enrollment": 4500, "start_date": "2026-06-29", "registry_url": "https://clinicaltrials.gov/study/NCT07667803" }, { "nct_id": "NCT06890039", "title": "A-TANGO Phase 2 Study", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Yaqrit Ltd", "conditions": [ "Acute-On-Chronic Liver Failure", "Alcoholic Hepatitis", "Liver Cirrhosis, Alcoholic" ], "sites": [ "London" ], "enrollment": 78, "start_date": "2026-06-29", "registry_url": "https://clinicaltrials.gov/study/NCT06890039" }, { "nct_id": "NCT07764978", "title": "Study of AZD0120 in Newly Diagnosed Multiple Myeloma Ineligible for ASCT", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "AstraZeneca", "conditions": [ "Newly Diagnosed Multiple Myeloma" ], "sites": [ "Edinburgh", "London", "Manchester" ], "enrollment": 750, "start_date": "2026-06-26", "registry_url": "https://clinicaltrials.gov/study/NCT07764978" }, { "nct_id": "NCT07269665", "title": "First-in-Human, Dose Escalation Trial of AXV-101 in BBS1-Related Retinal Degeneration", "status": "RECRUITING", "phase": "Early Phase 1", "lead_sponsor": "Axovia Therapeutics", "conditions": [ "Bardet-Biedl Syndrome 1", "Retinal Degeneration" ], "sites": [ "London" ], "enrollment": 12, "start_date": "2026-06-26", "registry_url": "https://clinicaltrials.gov/study/NCT07269665" }, { "nct_id": "NCT06607783", "title": "PRostate Cancer Enhanced Diagnosis by Calibration Technology", "status": "RECRUITING", "phase": "Observational", "lead_sponsor": "Gold Standard Phantoms", "conditions": [ "Prostate Cancers" ], "sites": [ "London" ], "enrollment": 66, "start_date": "2026-06-26", "registry_url": "https://clinicaltrials.gov/study/NCT06607783" }, { "nct_id": "NCT07650916", "title": "A Study to Investigate Cabotegravir Ultra Long-Acting (CAB ULA) Plus Rilpivirine Ultra Long-Acting (RPV ULA) in Adults and Adolescents With HIV Who Are Virologically Suppressed", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "ViiV Healthcare", "conditions": [ "HIV Infections" ], "sites": [ "Birmingham", "Liverpool", "London" ], "enrollment": 564, "start_date": "2026-06-25", "registry_url": "https://clinicaltrials.gov/study/NCT07650916" }, { "nct_id": "NCT07555938", "title": "Cevostamab in Combination With Pomalidomide and Dexamethasone Versus Standard of Care in Participants With Previously Treated Multiple Myeloma", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Multiple Myeloma" ], "sites": [ "London", "Oxford", "Wolverhampton" ], "enrollment": 380, "start_date": "2026-06-23", "registry_url": "https://clinicaltrials.gov/study/NCT07555938" }, { "nct_id": "NCT07694440", "title": "A Study of MZE782 in Adults With PKU", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Maze Therapeutics", "conditions": [ "Phenylketonuria (PKU)" ], "sites": [ "London" ], "enrollment": 38, "start_date": "2026-06-23", "registry_url": "https://clinicaltrials.gov/study/NCT07694440" }, { "nct_id": "NCT07602777", "title": "A Study Evaluating the Efficacy and Safety of Risvutatug Rezetecan in Participants With Advanced Sarcomas (EMBOLD Sarcoma-202)", "status": "RECRUITING", "phase": "Phase 1/2", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Sarcoma" ], "sites": [ "Manchester", "London" ], "enrollment": 64, "start_date": "2026-06-22", "registry_url": "https://clinicaltrials.gov/study/NCT07602777" }, { "nct_id": "NCT07554339", "title": "A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015)", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Non-small Cell Lung Cancer" ], "sites": [ "Leeds" ], "enrollment": 310, "start_date": "2026-06-18", "registry_url": "https://clinicaltrials.gov/study/NCT07554339" }, { "nct_id": "NCT07286266", "title": "A Study to Investigate Mocertatug Rezetecan Compared With Standard of Care in Participants With Platinum-resistant Ovarian Cancer (BEHOLD-Ovarian01)", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Ovarian Neoplasms" ], "sites": [ "London" ], "enrollment": 450, "start_date": "2026-06-18", "registry_url": "https://clinicaltrials.gov/study/NCT07286266" }, { "nct_id": "NCT05906004", "title": "Post-Market Clinical Follow-up (PMCF) Study of the Pitch-Patch for the Augmentation or Reinforcement of the Rotator Cuff", "status": "RECRUITING", "phase": "Observational", "lead_sponsor": "Xiros Ltd", "conditions": [ "Rotator Cuff Tear", "Rotator Cuff Tears", "Rotator Cuff Tears of the Shoulder", "Rotator Cuff Injuries" ], "sites": [ "Reading" ], "enrollment": 37, "start_date": "2026-06-16", "registry_url": "https://clinicaltrials.gov/study/NCT05906004" }, { "nct_id": "NCT07652658", "title": "A Phase IIb Study to Evaluate AZD8965 in Participants With IPF.", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "AstraZeneca", "conditions": [ "Idiopathic Pulmonary Fibrosis (IPF)" ], "sites": [ "Bristol", "Cottingham", "Edinburgh", "Exeter", "Liverpool", "London" ], "enrollment": 359, "start_date": "2026-06-11", "registry_url": "https://clinicaltrials.gov/study/NCT07652658" }, { "nct_id": "NCT07608354", "title": "A Study to Evaluate the Efficacy and Safety of Concomitant Use of Eplontersen and ALXN2220 Compared With Eplontersen and Placebo for Adults Participants With ATTR-CM", "status": "ACTIVE_NOT_RECRUITING", "phase": "Phase 2", "lead_sponsor": "AstraZeneca", "conditions": [ "Transthyretin Amyloid Cardiomyopathy (ATTR-CM)" ], "sites": [ "London" ], "enrollment": 326, "start_date": "2026-06-11", "registry_url": "https://clinicaltrials.gov/study/NCT07608354" }, { "nct_id": "NCT07883954", "title": "Development and Multi-Centre Validation of a Novel Non-Invasive Melanoma Molecular Diagnostic Test", "status": "RECRUITING", "phase": "Observational", "lead_sponsor": "Mitra Bio", "conditions": [ "Melanoma" ], "sites": [ "London" ], "enrollment": 2000, "start_date": "2026-06-10", "registry_url": "https://clinicaltrials.gov/study/NCT07883954" }, { "nct_id": "NCT07583563", "title": "An Observational Study of Octreotide Subcutaneous Depot in Patients With Acromegaly", "status": "RECRUITING", "phase": "Observational", "lead_sponsor": "Camurus AB", "conditions": [ "Acromegaly" ], "sites": [ "Leeds" ], "enrollment": 200, "start_date": "2026-06-05", "registry_url": "https://clinicaltrials.gov/study/NCT07583563" }, { "nct_id": "NCT07678775", "title": "Open-Label Extension Study of BBP-418 (Ribitol) for LGMD2I/R9", "status": "ACTIVE_NOT_RECRUITING", "phase": "Phase 3", "lead_sponsor": "ML Bio Solutions, Inc.", "conditions": [ "Limb-Girdle Muscular Dystrophy Type 2I (LGMD2I)" ], "sites": [ "London", "Newcastle upon Tyne" ], "enrollment": 107, "start_date": "2026-06-05", "registry_url": "https://clinicaltrials.gov/study/NCT07678775" }, { "nct_id": "NCT07562152", "title": "Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Immuneering Corporation", "conditions": [ "Pancreatic Cancer", "Pancreatic Cancer Metastatic", "PDAC", "PDAC - Pancreatic Ductal Adenocarcinoma" ], "sites": [ "Coventry", "London", "Manchester" ], "enrollment": 510, "start_date": "2026-06-05", "registry_url": "https://clinicaltrials.gov/study/NCT07562152" }, { "nct_id": "NCT07359820", "title": "A Study of Lirafugratinib in Non-CCA Solid Tumors With FGFR2 Fusion or Rearrangement", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Elevar Therapeutics", "conditions": [ "FGFR2 Gene Fusion/Rearrangement", "Other Solid Tumors, Adult" ], "sites": [ "London", "Manchester" ], "enrollment": 30, "start_date": "2026-06-04", "registry_url": "https://clinicaltrials.gov/study/NCT07359820" }, { "nct_id": "NCT07286331", "title": "A Study to Investigate Mocertatug Rezetecan Compared With Chemotherapy in Participants With Endometrial Cancer After Platinum-based Chemotherapy and Immunotherapy (BEHOLD-Endometrial01)", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Neoplasms, Endometrial" ], "sites": [ "Sutton", "Leicester", "London" ], "enrollment": 600, "start_date": "2026-06-04", "registry_url": "https://clinicaltrials.gov/study/NCT07286331" }, { "nct_id": "NCT07024706", "title": "MAVRiC Studies 2L Treatment With AV in Patients With CLL/SLL Who Have Relapsed After a Course of BTKi + BCL2i Combination, With or Without Obinutuzumab", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "AstraZeneca", "conditions": [ "Chronic Lymphocytic Leukemia (CLL)", "Small Lymphocytic Lymphoma (SLL)" ], "sites": [ "Colchester", "Derby", "Edgbaston", "Exeter", "Leeds", "London", "Southampton" ], "enrollment": 80, "start_date": "2026-06-04", "registry_url": "https://clinicaltrials.gov/study/NCT07024706" }, { "nct_id": "NCT07590934", "title": "Phase Ib/II Platform Study of Multiple Anti-Cancer Agents in Participants With Metastatic Prostate Cancer", "status": "RECRUITING", "phase": "Phase 1/2", "lead_sponsor": "AstraZeneca", "conditions": [ "Metastatic Prostate Cancer" ], "sites": [ "Belfast", "Fulham", "Guildford", "London", "Newcastle upon Tyne", "Oxford" ], "enrollment": 152, "start_date": "2026-06-03", "registry_url": "https://clinicaltrials.gov/study/NCT07590934" }, { "nct_id": "NCT07498426", "title": "A Study to Evaluate the Efficacy of NIO752 in Participants With Progressive Supranuclear Palsy", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Progressive Supranuclear Palsy Richardson Syndrome (PSP-RS)" ], "sites": [ "Cambridge", "London" ], "enrollment": 300, "start_date": "2026-06-03", "registry_url": "https://clinicaltrials.gov/study/NCT07498426" }, { "nct_id": "NCT07519902", "title": "An Efficacy and Safety Study of Cenegermin Ophthalmic Solution Compared With Vehicle in the Treatment of PCED", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Domp\u00e9 Farmaceutici S.p.A", "conditions": [ "Persistent Corneal Epithelial Defect" ], "sites": [ "Bristol", "Liverpool", "London", "Nottingham" ], "enrollment": 150, "start_date": "2026-06-02", "registry_url": "https://clinicaltrials.gov/study/NCT07519902" }, { "nct_id": "NCT07477470", "title": "BALANCE Study: Beneficial Effects of A Diverse Prebiotic Fibre bLend on Affect, iNflammation, Cognition, and the Gut microbiomE", "status": "RECRUITING", "phase": "Not applicable", "lead_sponsor": "Myota GmbH", "conditions": [ "Stress" ], "sites": [ "London" ], "enrollment": 120, "start_date": "2026-06-01", "registry_url": "https://clinicaltrials.gov/study/NCT07477470" }, { "nct_id": "NCT07613294", "title": "A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Atherosclerosis", "Cardiovascular Diseases", "Lipoprotein(a)" ], "sites": [ "Birmingham", "Bristol", "Cheadle", "Lancaster", "Lincoln", "Newcastle", "Oxford", "Sheffield" ], "enrollment": 252, "start_date": "2026-06-01", "registry_url": "https://clinicaltrials.gov/study/NCT07613294" }, { "nct_id": "NCT07192952", "title": "A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Bayer", "conditions": [ "Left Ventricular Systolic Dysfunction", "Heart Failure (Pediatric)" ], "sites": [ "Leicester", "Liverpool", "Belfast", "Glasgow", "Newcastle upon Tyne", "Leeds", "Bristol" ], "enrollment": 117, "start_date": "2026-06-01", "registry_url": "https://clinicaltrials.gov/study/NCT07192952" }, { "nct_id": "NCT07677280", "title": "A Consumer Use Behavior Study to Measure the Puffing Topography of Heated Tobacco Products", "status": "NOT_YET_RECRUITING", "phase": "Not applicable", "lead_sponsor": "RAI Services Company", "conditions": [ "Cigarette Smokers" ], "sites": [ "Cheshunt", "Sheffield" ], "enrollment": 200, "start_date": "2026-06", "registry_url": "https://clinicaltrials.gov/study/NCT07677280" }, { "nct_id": "NCT07413926", "title": "Mitral Valve Repair With the Chord-X System: A Long Term Evaluation", "status": "NOT_YET_RECRUITING", "phase": "Observational", "lead_sponsor": "Artivion Inc.", "conditions": [ "Mitral Regurgitation (MR)" ], "sites": [ "Blackpool", "Middlesbrough" ], "enrollment": 110, "start_date": "2026-06", "registry_url": "https://clinicaltrials.gov/study/NCT07413926" }, { "nct_id": "NCT07503405", "title": "Phase 2a Study of the Efficacy and Safety of TRX-100 in a Human Influenza A Challenge Model", "status": "NOT_YET_RECRUITING", "phase": "Phase 2", "lead_sponsor": "Traws Pharma, Inc.", "conditions": [ "Influenza" ], "sites": [ "London" ], "enrollment": 165, "start_date": "2026-06", "registry_url": "https://clinicaltrials.gov/study/NCT07503405" }, { "nct_id": "NCT07607496", "title": "MacuTherm Performance Study in Patients With iAMD", "status": "RECRUITING", "phase": "Not applicable", "lead_sponsor": "OD-OS MacuTherm GmbH", "conditions": [ "Intermediate AMD" ], "sites": [ "Sunderland" ], "enrollment": 240, "start_date": "2026-05-29", "registry_url": "https://clinicaltrials.gov/study/NCT07607496" }, { "nct_id": "NCT07470879", "title": "A Study of How the Medicine Called \"Etrasimod\" Works in Children With the Gut Disease Called Ulcerative Colitis", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Pfizer", "conditions": [ "Colitis, Ulcerative" ], "sites": [ "London", "Bristol", "Liverpool", "Sheffield" ], "enrollment": 24, "start_date": "2026-05-28", "registry_url": "https://clinicaltrials.gov/study/NCT07470879" }, { "nct_id": "NCT07101328", "title": "A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Lymphoma, Non-Hodgkin", "B-cell Lymphoma", "Lymphoma, Large B-Cell, Diffuse", "Lymphoma, Follicular" ], "sites": [ "Leeds", "Oxford" ], "enrollment": 215, "start_date": "2026-05-28", "registry_url": "https://clinicaltrials.gov/study/NCT07101328" }, { "nct_id": "NCT07429266", "title": "INTREPID: A Study of Sapablursen Evaluating the Safety and Efficacy in Participants With Polycythemia Vera (PV)", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Ono Pharmaceutical Co., Ltd.", "conditions": [ "Polycythemia Vera" ], "sites": [ "Exeter", "London", "Newcastle upon Tyne", "Newport", "Nottingham", "Oxford", "Windsor" ], "enrollment": 250, "start_date": "2026-05-25", "registry_url": "https://clinicaltrials.gov/study/NCT07429266" }, { "nct_id": "NCT07577856", "title": "A Study of JNJ-78934804 in Participants With Moderately to Severely Active Ulcerative Colitis", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Janssen Research & Development, LLC", "conditions": [ "Colitis, Ulcerative" ], "sites": [ "Cambridge", "Cardiff", "Dundee", "Leytonstone", "London", "Newcastle upon Tyne" ], "enrollment": 644, "start_date": "2026-05-23", "registry_url": "https://clinicaltrials.gov/study/NCT07577856" }, { "nct_id": "NCT07621718", "title": "Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of Investigator's Choice as First-line Treatment in Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma ( RASolute 305 )", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Revolution Medicines, Inc.", "conditions": [ "Pancreatic Cancer", "Pancreatic Cancer Metastatic", "PDAC", "PDAC - Pancreatic Ductal Adenocarcinoma" ], "sites": [ "London" ], "enrollment": 670, "start_date": "2026-05-22", "registry_url": "https://clinicaltrials.gov/study/NCT07621718" }, { "nct_id": "NCT07577843", "title": "A Study of JNJ-78934804 in Participants With Moderately to Severely Active Crohn's Disease", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Janssen Research & Development, LLC", "conditions": [ "Crohn Disease" ], "sites": [ "Birmingham", "Cardiff", "Dundee", "Glasgow", "London", "Newcastle upon Tyne" ], "enrollment": 460, "start_date": "2026-05-22", "registry_url": "https://clinicaltrials.gov/study/NCT07577843" }, { "nct_id": "NCT07479797", "title": "Study Evaluating the Efficacy of KITE-753 Versus Axicabtagene Ciloleucel in Participants With Relapsed or Refractory Large B-Cell Lymphoma After First-Line Therapy", "status": "ACTIVE_NOT_RECRUITING", "phase": "Phase 3", "lead_sponsor": "Kite, A Gilead Company", "conditions": [ "Relapsed or Refractory Large B-cell Lymphoma" ], "sites": [ "Cardiff", "London", "Newcastle upon Tyne" ], "enrollment": 550, "start_date": "2026-05-22", "registry_url": "https://clinicaltrials.gov/study/NCT07479797" }, { "nct_id": "NCT07492641", "title": "BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "BeOne Medicines", "conditions": [ "HR+/HER2- Breast Cancer" ], "sites": [ "Guildford", "Maidstone" ], "enrollment": 1056, "start_date": "2026-05-22", "registry_url": "https://clinicaltrials.gov/study/NCT07492641" }, { "nct_id": "NCT07413939", "title": "RO7771950 Versus Tucatinib in Combination With Trastuzumab and Capecitabine in People With Locally Advanced or Metastatic Breast Cancer That is Human Epidermal Growth Factor Receptor 2 (HER2)-Positive", "status": "RECRUITING", "phase": "Phase 2/3", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "HER2-positive Breast Cancer" ], "sites": [ "Leicester", "Liverpool", "London", "Manchester", "Montacute" ], "enrollment": 650, "start_date": "2026-05-21", "registry_url": "https://clinicaltrials.gov/study/NCT07413939" }, { "nct_id": "NCT07554495", "title": "Safety, Tolerability, Pharmacokinetics, and Efficacy of Filgotinib for the Treatment of Polyarticular-course Juvenile Idiopathic Arthritis in Children and Adolescents", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Alfasigma S.p.A.", "conditions": [ "Polyarticular Course Juvenile Idiopathic Arthritis" ], "sites": [ "Bristol", "Leicester", "Nottingham" ], "enrollment": 65, "start_date": "2026-05-21", "registry_url": "https://clinicaltrials.gov/study/NCT07554495" }, { "nct_id": "NCT07393282", "title": "A Study to Compare Linvoseltamab and Daratumumab Treatment in High-Risk Smoldering Multiple Myeloma (HR-SMM)", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Regeneron Pharmaceuticals", "conditions": [ "High Risk Smoldering Multiple Myeloma (HR-SMM)" ], "sites": [ "Truro", "Norwich", "Leicester", "London" ], "enrollment": 270, "start_date": "2026-05-21", "registry_url": "https://clinicaltrials.gov/study/NCT07393282" }, { "nct_id": "NCT07422480", "title": "A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Lower Risk Myelodysplastic Syndromes (LR-MDS) Who Need Regular Blood Transfusions", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Takeda", "conditions": [ "Myelodysplastic Syndrome", "Anemia" ], "sites": [ "Leicester", "Boston", "Oxford", "Birmingham", "London", "Manchester" ], "enrollment": 300, "start_date": "2026-05-21", "registry_url": "https://clinicaltrials.gov/study/NCT07422480" }, { "nct_id": "NCT07124078", "title": "A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256)", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Incyte Corporation", "conditions": [ "Chronic Graft-versus-host-disease" ], "sites": [ "Birmingham", "Cambridge", "Glasgow", "Leeds", "London", "Manchester", "Newcastle", "Sheffield" ], "enrollment": 60, "start_date": "2026-05-20", "registry_url": "https://clinicaltrials.gov/study/NCT07124078" }, { "nct_id": "NCT07306832", "title": "A Study to Assess Adverse Events and How Intravenous (IV) Pivekimab Sunirine Moves Through the Body in Pediatric Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML)", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "AbbVie", "conditions": [ "Acute Myeloid Leukemia" ], "sites": [ "Cambridge" ], "enrollment": 18, "start_date": "2026-05-20", "registry_url": "https://clinicaltrials.gov/study/NCT07306832" }, { "nct_id": "NCT07553637", "title": "ALTO-207 in Adults With Treatment-resistant Depression (TRD)", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Alto Neuroscience", "conditions": [ "Treatment-resistant Depression (TRD)" ], "sites": [ "Antrim", "Birmingham", "Bristol", "Cardiff", "Exeter", "London", "Nottingham", "Oxford" ], "enrollment": 178, "start_date": "2026-05-20", "registry_url": "https://clinicaltrials.gov/study/NCT07553637" }, { "nct_id": "NCT06948214", "title": "Phase 3 Study of LUM-201 in Children With Growth Hormone Deficiency", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Lumos Pharma", "conditions": [ "Growth Hormone Deficiency (GHD)" ], "sites": [ "Liverpool", "London", "Manchester", "Sheffield" ], "enrollment": 150, "start_date": "2026-05-20", "registry_url": "https://clinicaltrials.gov/study/NCT06948214" }, { "nct_id": "NCT07422610", "title": "Pharmacokinetics and Safety Study of Pelabresib in Patients With Advanced Malignancies and Hepatic Impairment", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Advanced Malignancies and Hepatic Impairment" ], "sites": [ "London" ], "enrollment": 24, "start_date": "2026-05-19", "registry_url": "https://clinicaltrials.gov/study/NCT07422610" }, { "nct_id": "NCT07392450", "title": "A Study of TAK-755 in Adults With Acute Ischemic Stroke", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Takeda", "conditions": [ "Acute Ischemic Stroke" ], "sites": [ "Cornhill", "Luton", "Glasgow", "London" ], "enrollment": 222, "start_date": "2026-05-17", "registry_url": "https://clinicaltrials.gov/study/NCT07392450" }, { "nct_id": "NCT07416526", "title": "A Clinical Study to Evaluate the Effects of NXT007 Compared to Factor VIII Prophylaxis in Participants With Hemophilia A", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Hemophilia A" ], "sites": [ "London", "Cardiff", "Oxford" ], "enrollment": 138, "start_date": "2026-05-15", "registry_url": "https://clinicaltrials.gov/study/NCT07416526" }, { "nct_id": "NCT07785960", "title": "Recovery and Early Sleep Tracking Using the SuperPatch REM Patch", "status": "ENROLLING_BY_INVITATION", "phase": "Not applicable", "lead_sponsor": "SuperPatch Limited LLC", "conditions": [ "Shift Work Sleep Disorder", "Shift Work Type Circadian Rhythm Sleep Disorder", "Shift Work Sleep Disorders" ], "sites": [ "Birmingham" ], "enrollment": 20, "start_date": "2026-05-15", "registry_url": "https://clinicaltrials.gov/study/NCT07785960" }, { "nct_id": "NCT07486934", "title": "Efficacy, Safety, and Tolerability of Zeleciment Basivarsen (DYNE-101) in Participants With Myotonic Dystrophy Type 1", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Dyne Therapeutics", "conditions": [ "Myotonic Dystrophy Type 1 (DM1)", "DM1", "Myotonic Dystrophy", "Steinert Disease" ], "sites": [ "London", "Salford" ], "enrollment": 150, "start_date": "2026-05-14", "registry_url": "https://clinicaltrials.gov/study/NCT07486934" }, { "nct_id": "NCT07387549", "title": "A Study to Assess How Well and Safely Elafibranor Works in Adult Participants With Primary Sclerosing Cholangitis", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Ipsen", "conditions": [ "Primary Sclerosing Cholangitis" ], "sites": [ "Frimley", "London", "Norwich", "Oxford", "Cottingham", "Aberdeen", "Birmingham", "Glasgow" ], "enrollment": 350, "start_date": "2026-05-14", "registry_url": "https://clinicaltrials.gov/study/NCT07387549" }, { "nct_id": "NCT07501702", "title": "A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis", "status": "ACTIVE_NOT_RECRUITING", "phase": "Phase 2", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Myasthenia Gravis, Generalized" ], "sites": [ "Birmingham", "London", "Salford" ], "enrollment": 34, "start_date": "2026-05-13", "registry_url": "https://clinicaltrials.gov/study/NCT07501702" }, { "nct_id": "NCT07572006", "title": "A Study of JNJ-95804306 for Relapsed or Refractory Hematological Malignancies", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "Janssen Research & Development, LLC", "conditions": [ "Hematologic Neoplasms" ], "sites": [ "Manchester" ], "enrollment": 360, "start_date": "2026-05-13", "registry_url": "https://clinicaltrials.gov/study/NCT07572006" }, { "nct_id": "NCT07536061", "title": "A First-in-human Study of the Effects of SRP-1005 in Participants With Huntington's Disease", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "Sarepta Therapeutics, Inc.", "conditions": [ "Huntington's Disease" ], "sites": [ "Cardiff" ], "enrollment": 32, "start_date": "2026-05-12", "registry_url": "https://clinicaltrials.gov/study/NCT07536061" }, { "nct_id": "NCT07539311", "title": "Study to Assess the Efficacy and Safety of Rina-S in Participants With Advanced Gastrointestinal (GI) Cancers", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Genmab", "conditions": [ "Gastrointestinal Cancers" ], "sites": [ "London" ], "enrollment": 160, "start_date": "2026-05-11", "registry_url": "https://clinicaltrials.gov/study/NCT07539311" }, { "nct_id": "NCT07441694", "title": "Study of INCA036978 in Participants With Myeloproliferative Neoplasms", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "Incyte Corporation", "conditions": [ "Myeloproliferative Neoplasms" ], "sites": [ "London", "Nottingham", "Oxford" ], "enrollment": 218, "start_date": "2026-05-11", "registry_url": "https://clinicaltrials.gov/study/NCT07441694" }, { "nct_id": "NCT07517263", "title": "An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)", "status": "ACTIVE_NOT_RECRUITING", "phase": "Phase 3", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Cardiovascular Disease and Lipoprotein(a)" ], "sites": [ "Dorchester", "London", "Preston", "Harrow", "Rochdale", "Portadown", "Taunton", "Chertsey" ], "enrollment": 5700, "start_date": "2026-05-11", "registry_url": "https://clinicaltrials.gov/study/NCT07517263" }, { "nct_id": "NCT07613723", "title": "A Study to Test the Safety, Tolerability and Effect of ZI-MA4-1 for Patients With Locally Advanced or Metastatic Solid Malignancies", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "Zelluna Immunotherapy AS", "conditions": [ "Ovarian Cancer", "Squamous Non-Small Cell Lung Cancer (NSCLC)", "Synovial Sarcomas", "Head and Neck Cancer" ], "sites": [ "London", "Manchester" ], "enrollment": 9, "start_date": "2026-05-11", "registry_url": "https://clinicaltrials.gov/study/NCT07613723" }, { "nct_id": "NCT07567001", "title": "A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Obesity", "Heart Failure" ], "sites": [ "Truro", "Rhyl", "Torquay", "Dorchester", "Airdrie", "Tooting", "Isleworth", "Norwich" ], "enrollment": 5610, "start_date": "2026-05-11", "registry_url": "https://clinicaltrials.gov/study/NCT07567001" }, { "nct_id": "NCT07415031", "title": "A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Mirati Therapeutics Inc.", "conditions": [ "Solid Tumors" ], "sites": [ "London", "Birmingham", "Leicester" ], "enrollment": 170, "start_date": "2026-05-06", "registry_url": "https://clinicaltrials.gov/study/NCT07415031" }, { "nct_id": "NCT07427394", "title": "Study to Evaluate the Safety and Tolerability of Camizestrant in Combination With Atirmociclib in Women With Advanced Breast Cancer", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "AstraZeneca", "conditions": [ "Advanced Breast Cancer" ], "sites": [ "Cambridge", "London", "Manchester" ], "enrollment": 24, "start_date": "2026-05-06", "registry_url": "https://clinicaltrials.gov/study/NCT07427394" }, { "nct_id": "NCT07614958", "title": "Phase 3 Clinical Study Evaluating Efficacy, Safety, and Tolerability of Obicetrapib Vs Bempedoic Acid to Treat Dyslipidemia in Adults With Primary Non-familial Hypercholesterolemia or Mixed Dyslipidemia at High to Very High Cardiovascular Risk, During a Treatment Period of Approximately 84 Days", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "A. Menarini International Licensing S.A.", "conditions": [ "Mixed Dyslipidemia", "Hypercholesterolaemia" ], "sites": [ "Stockton-on-Tees" ], "enrollment": 426, "start_date": "2026-05-06", "registry_url": "https://clinicaltrials.gov/study/NCT07614958" }, { "nct_id": "NCT07318597", "title": "Study of REGN13335 in Adult Participants With Pulmonary Arterial Hypertension (PAH)", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Regeneron Pharmaceuticals", "conditions": [ "Pulmonary Arterial Hypertension (PAH)" ], "sites": [ "Bath", "London" ], "enrollment": 99, "start_date": "2026-05-06", "registry_url": "https://clinicaltrials.gov/study/NCT07318597" }, { "nct_id": "NCT07549412", "title": "A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "EMD Serono Research & Development Institute, Inc.", "conditions": [ "Metastatic Colorectal Cancer" ], "sites": [ "Aberdeen", "Manchester", "London" ], "enrollment": 1020, "start_date": "2026-05-06", "registry_url": "https://clinicaltrials.gov/study/NCT07549412" }, { "nct_id": "NCT07555548", "title": "UK PureWick\u2122 At-Home Pilot Study", "status": "RECRUITING", "phase": "Observational", "lead_sponsor": "Becton, Dickinson and Company", "conditions": [ "Urinary Incontinence" ], "sites": [ "Doncaster", "Leicester", "Northampton", "Norwich" ], "enrollment": 95, "start_date": "2026-05-06", "registry_url": "https://clinicaltrials.gov/study/NCT07555548" }, { "nct_id": "NCT07545759", "title": "A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Diarrhea (IBS-D)", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Irritable Bowel Syndrome", "Diarrhea" ], "sites": [ "Cheadle", "Hounslow", "Macclesfield", "Newcastle upon Tyne", "Newquay", "Rotherham", "Surrey", "Sutton in Ashfield" ], "enrollment": 531, "start_date": "2026-05-06", "registry_url": "https://clinicaltrials.gov/study/NCT07545759" }, { "nct_id": "NCT05199688", "title": "A Study to Evaluate Pharmacokinetics, Efficacy, Safety, Tolerability, and Pharmacodynamics of Satralizumab in Pediatric Patients With Aquaporin-4 Antibody Positive Neuromyelitis Optica Spectrum Disorder (NMOSD)", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Neuromyelitis Optica Spectrum Disorder", "NMOSD" ], "sites": [ "London" ], "enrollment": 8, "start_date": "2026-05-06", "registry_url": "https://clinicaltrials.gov/study/NCT05199688" }, { "nct_id": "NCT07509151", "title": "Surovatamig as Consolidation Therapy in Participants With Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated Immunoglobulin Heavy Chain Variable (IGHV)", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "AstraZeneca", "conditions": [ "Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated IGHV" ], "sites": [ "Edinburgh", "Hampshire", "Leeds", "London", "Manchester", "Nottingham", "Oxford", "Sutton" ], "enrollment": 420, "start_date": "2026-05-05", "registry_url": "https://clinicaltrials.gov/study/NCT07509151" }, { "nct_id": "NCT07513376", "title": "A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Non-small Cell Lung Cancer" ], "sites": [ "London", "Swansea" ], "enrollment": 876, "start_date": "2026-05-04", "registry_url": "https://clinicaltrials.gov/study/NCT07513376" }, { "nct_id": "NCT07611110", "title": "AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "AstraZeneca", "conditions": [ "Metastatic Castration-resistant Prostate Cancer" ], "sites": [ "London", "Middlesbrough", "Southampton", "Truro" ], "enrollment": 670, "start_date": "2026-05-04", "registry_url": "https://clinicaltrials.gov/study/NCT07611110" }, { "nct_id": "NCT07519772", "title": "A Clinical Study of MK-1045 in People With Non-Hodgkin Lymphoma (MK-1045-008)", "status": "RECRUITING", "phase": "Phase 1/2", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Lymphoma, Non-Hodgkin", "Lymphoma, Follicular", "Lymphoma, Large B-Cell, Diffuse" ], "sites": [ "Plymouth", "Manchester" ], "enrollment": 280, "start_date": "2026-05-03", "registry_url": "https://clinicaltrials.gov/study/NCT07519772" }, { "nct_id": "NCT07335588", "title": "A 52-Week Trial to Investigate the Efficacy and Safety of Delgocitinib Cream in Adult Participants With Lichen Sclerosus", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "LEO Pharma", "conditions": [ "Lichen Sclerosus" ], "sites": [ "Liverpool", "London" ], "enrollment": 652, "start_date": "2026-05-01", "registry_url": "https://clinicaltrials.gov/study/NCT07335588" }, { "nct_id": "NCT07610395", "title": "Trial Comparing the Safety and Efficacy of Two Different Oral VPV Doses With Placebo as Treatment for RV in Participants With COPD", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Altesa Biosciences, Inc.", "conditions": [ "Rhinovirus Infection" ], "sites": [ "Bromborough", "Glasgow", "London", "Milton Keynes", "Wolverhampton" ], "enrollment": 180, "start_date": "2026-05-01", "registry_url": "https://clinicaltrials.gov/study/NCT07610395" }, { "nct_id": "NCT07567131", "title": "Observational Study of Adults and Adolescents With Erythropoietic Protoporphyria (EPP) and X-linked Porphyria (XLP)", "status": "RECRUITING", "phase": "Observational", "lead_sponsor": "Portal Therapeutics, Inc.", "conditions": [ "Erythropoietic Protoporphyria (EPP)", "X-Linked Porphyria (XLP)" ], "sites": [ "Cardiff", "Dundee", "London", "Manchester" ], "enrollment": 50, "start_date": "2026-04-30", "registry_url": "https://clinicaltrials.gov/study/NCT07567131" }, { "nct_id": "NCT07490301", "title": "A Study to Assess Intravenous (IV) Telisotuzumab Adizutecan in Combination With Fluorouracil, Folinic Acid, and Oxaliplatin (FOLFOX) Compared to Standard of Care in Adult Participants With First-Line Metastatic Pancreatic Ductal Adenocarcinoma", "status": "RECRUITING", "phase": "Phase 2/3", "lead_sponsor": "AbbVie", "conditions": [ "Metastatic Pancreatic Ductal Adenocarcinoma", "PDAC" ], "sites": [ "Oxford" ], "enrollment": 900, "start_date": "2026-04-30", "registry_url": "https://clinicaltrials.gov/study/NCT07490301" }, { "nct_id": "NCT07567846", "title": "A Study Evaluating the Safety, Pharmacokinetics, and Preliminary Activity of GDC-1261 in Participants With Advanced or Metastatic Prostate Cancer", "status": "RECRUITING", "phase": "Phase 1/2", "lead_sponsor": "Genentech, Inc.", "conditions": [ "Advanced Prostate Cancer", "Metastatic Prostate Cancer" ], "sites": [ "Sutton" ], "enrollment": 260, "start_date": "2026-04-29", "registry_url": "https://clinicaltrials.gov/study/NCT07567846" }, { "nct_id": "NCT07545772", "title": "A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Constipation (IBS-C)", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Irritable Bowel Syndrome", "Constipation" ], "sites": [ "Cheadle", "Hounslow", "Macclesfield", "Newcastle upon Tyne", "Newquay", "Rotherham", "Surrey", "Sutton in Ashfield" ], "enrollment": 342, "start_date": "2026-04-29", "registry_url": "https://clinicaltrials.gov/study/NCT07545772" }, { "nct_id": "NCT07416604", "title": "A Clinical Study to Evaluate the Effects of NXT007 Compared to Emicizumab Prophylaxis in People With Hemophilia A", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Hemophilia A" ], "sites": [ "London", "Cardiff" ], "enrollment": 360, "start_date": "2026-04-27", "registry_url": "https://clinicaltrials.gov/study/NCT07416604" }, { "nct_id": "NCT07365332", "title": "An Adaptive Program of IKT-001 in Pulmonary Arterial Hypertension (PAH)", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Inhibikase Therapeutics", "conditions": [ "Pulmonary Arterial Hypertension" ], "sites": [ "Cambridge", "Glasgow", "London" ], "enrollment": 486, "start_date": "2026-04-23", "registry_url": "https://clinicaltrials.gov/study/NCT07365332" }, { "nct_id": "NCT07285655", "title": "A Phase 3 Study to Evaluate the Safety and Efficacy L606 in Participants With PH-ILD", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Liquidia Technologies, Inc.", "conditions": [ "Pulmonary Hypertension Due to Lung Disease (Disorder)" ], "sites": [ "Bath", "London", "Plymouth", "Sheffield" ], "enrollment": 344, "start_date": "2026-04-23", "registry_url": "https://clinicaltrials.gov/study/NCT07285655" }, { "nct_id": "NCT07419295", "title": "A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) to Treat Urothelial Cancer (MK-2870-031)", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Bladder Cancer" ], "sites": [ "Cambridge", "London" ], "enrollment": 590, "start_date": "2026-04-23", "registry_url": "https://clinicaltrials.gov/study/NCT07419295" }, { "nct_id": "NCT07393373", "title": "Open-Label, Long-Term, Extension Study of Infigratinib in Children With Hypochondroplasia", "status": "ENROLLING_BY_INVITATION", "phase": "Phase 2", "lead_sponsor": "QED Therapeutics, a BridgeBio company", "conditions": [ "Hypochondroplasia" ], "sites": [ "Manchester", "Sheffield", "Glasgow" ], "enrollment": 135, "start_date": "2026-04-23", "registry_url": "https://clinicaltrials.gov/study/NCT07393373" }, { "nct_id": "NCT07365995", "title": "A Phase III Trial of BNT324 Versus Docetaxel in Metastatic Castration-resistant Prostate Cancer", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "BioNTech SE", "conditions": [ "Metastatic Castration-resistant Prostate Cancer" ], "sites": [ "Cambridge", "Cardiff", "Leeds", "London", "Newcastle upon Tyne", "Southampton", "Sutton" ], "enrollment": 736, "start_date": "2026-04-22", "registry_url": "https://clinicaltrials.gov/study/NCT07365995" }, { "nct_id": "NCT07478744", "title": "A Phase 2a Efficacy, Safety, Tolerability, and PK Study of SYT-510 in Participants With Generalized Anxiety Disorder", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Synendos Therapeutics AG", "conditions": [ "Generalized Anxiety Disorder" ], "sites": [ "London" ], "enrollment": 24, "start_date": "2026-04-22", "registry_url": "https://clinicaltrials.gov/study/NCT07478744" }, { "nct_id": "NCT07227207", "title": "A Study of TSRA-196 in Adults With PiZZ Alpha-1 Antitrypsin Deficiency (AATD)", "status": "RECRUITING", "phase": "Phase 1/2", "lead_sponsor": "Tessera Therapeutics, Inc.", "conditions": [ "Alpha-1 Antitrypsin Deficiency (AATD)" ], "sites": [ "London", "Nottingham" ], "enrollment": 72, "start_date": "2026-04-21", "registry_url": "https://clinicaltrials.gov/study/NCT07227207" }, { "nct_id": "NCT07499232", "title": "A Study of Guselkumab Versus Risankizumab in Participants With Moderately to Severely Active Crohn's Disease", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Janssen Research & Development, LLC", "conditions": [ "Crohn Disease" ], "sites": [ "Greater London", "Iselworth", "London", "Norwich", "Wolverhampton" ], "enrollment": 530, "start_date": "2026-04-21", "registry_url": "https://clinicaltrials.gov/study/NCT07499232" }, { "nct_id": "NCT07584265", "title": "Engagement Study for Participants With Factor V Leiden and Prothrombin G20210A Mutations", "status": "RECRUITING", "phase": "Observational", "lead_sponsor": "Richmond Research Institute", "conditions": [ "Factor V Leiden", "Prothrombin G20210A" ], "sites": [ "London" ], "enrollment": 100, "start_date": "2026-04-21", "registry_url": "https://clinicaltrials.gov/study/NCT07584265" }, { "nct_id": "NCT07830407", "title": "Pre-Clinical Validation of ChemoINTEL Unified Algorithm Chemotherapeutic Response Prediction in Patients With Colorectal Cancer", "status": "RECRUITING", "phase": "Observational", "lead_sponsor": "Pierian Biosciences", "conditions": [ "Colorectal Cancer" ], "sites": [ "Liverpool" ], "enrollment": 100, "start_date": "2026-04-21", "registry_url": "https://clinicaltrials.gov/study/NCT07830407" }, { "nct_id": "NCT07346144", "title": "Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma", "status": "RECRUITING", "phase": "Phase 1/2", "lead_sponsor": "Trogenix ltd", "conditions": [ "Glioblastoma (GBM)", "High Grade Gliomas", "Recurrent Glioblastoma", "Newly Diagnosed Glioblastoma" ], "sites": [ "Edinburgh" ], "enrollment": 68, "start_date": "2026-04-21", "registry_url": "https://clinicaltrials.gov/study/NCT07346144" }, { "nct_id": "NCT07503210", "title": "AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss", "status": "ACTIVE_NOT_RECRUITING", "phase": "Phase 3", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Obesity" ], "sites": [ "Macclesfield", "Rotherham", "Soham", "Wellingborough" ], "enrollment": 606, "start_date": "2026-04-21", "registry_url": "https://clinicaltrials.gov/study/NCT07503210" }, { "nct_id": "NCT07409181", "title": "A Study to Test Whether Different Doses of BI 3000202 Help People With Systemic Lupus Erythematosus (SLE)", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Systemic Lupus Erythematosus" ], "sites": [ "Basingstoke", "Belfast", "Cambridge", "Doncaster" ], "enrollment": 405, "start_date": "2026-04-20", "registry_url": "https://clinicaltrials.gov/study/NCT07409181" }, { "nct_id": "NCT07553182", "title": "OLE Study With Filgotinib in JIA", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Alfasigma S.p.A.", "conditions": [ "Juvenile Idiopathic Arthritis (JIA)" ], "sites": [ "London" ], "enrollment": 80, "start_date": "2026-04-20", "registry_url": "https://clinicaltrials.gov/study/NCT07553182" }, { "nct_id": "NCT07441876", "title": "Study to Evaluate the Efficacy and Safety of BMN 333 Versus Vosoritide in Children With Achondroplasia", "status": "RECRUITING", "phase": "Phase 2/3", "lead_sponsor": "BioMarin Pharmaceutical", "conditions": [ "Achondroplasia" ], "sites": [ "Bristol", "Glasgow", "Liverpool", "London", "Manchester" ], "enrollment": 160, "start_date": "2026-04-20", "registry_url": "https://clinicaltrials.gov/study/NCT07441876" }, { "nct_id": "NCT07136922", "title": "First in Human Safety and Ease of Use Assessment of 400mg Progesterone Callavid in Women With Luteal Phase Insufficiency", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "Calla Lily Clinical Care Ltd", "conditions": [ "Luteal Phase Insuffiency", "Progesterone Delivery" ], "sites": [ "Coventry" ], "enrollment": 20, "start_date": "2026-04-20", "registry_url": "https://clinicaltrials.gov/study/NCT07136922" }, { "nct_id": "NCT07573631", "title": "An Open-Label Extension Study to Evaluate the Long-term Safety and Efficacy of BMN 351 in Participants With Duchenne Muscular Dystrophy", "status": "ENROLLING_BY_INVITATION", "phase": "Phase 2", "lead_sponsor": "BioMarin Pharmaceutical", "conditions": [ "Duchenne Muscular Dystrophy (DMD)" ], "sites": [ "London" ], "enrollment": 18, "start_date": "2026-04-20", "registry_url": "https://clinicaltrials.gov/study/NCT07573631" }, { "nct_id": "NCT07226843", "title": "A Study of LY4584180 in Adult Participants With Previously Treated Blood Cancers", "status": "RECRUITING", "phase": "Phase 1", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Lymphoma, Non-Hodgkin's", "Lymphoma, Diffuse Large B-Cell", "Follicular Lymphoma" ], "sites": [ "London", "Nottingham", "Plymouth", "Southampton" ], "enrollment": 460, "start_date": "2026-04-17", "registry_url": "https://clinicaltrials.gov/study/NCT07226843" }, { "nct_id": "NCT07287670", "title": "EncompaSSc: Evaluation of MTX-474 in Participants With Diffuse Cutaneous Systemic Sclerosis (dcSSc)", "status": "RECRUITING", "phase": "Phase 2", "lead_sponsor": "Mediar Therapeutics", "conditions": [ "Diffuse Cutaneous Systemic Sclerosis" ], "sites": [ "Coventry", "Liverpool", "London", "Westcliff-on-Sea" ], "enrollment": 85, "start_date": "2026-04-16", "registry_url": "https://clinicaltrials.gov/study/NCT07287670" }, { "nct_id": "NCT07112196", "title": "Visugromab in Cachexia International Trial", "status": "RECRUITING", "phase": "Phase 2/3", "lead_sponsor": "CatalYm GmbH", "conditions": [ "Cancer-associated Cachexia" ], "sites": [ "Brighton", "Cambridge", "Dundee", "Edinburgh", "Guildford", "Manchester", "Newcastle upon Tyne" ], "enrollment": 518, "start_date": "2026-04-16", "registry_url": "https://clinicaltrials.gov/study/NCT07112196" }, { "nct_id": "NCT07158242", "title": "A Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Afimkibart (RO7790121) in Children With Moderately to Severely Active Ulcerative Colitis", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Moderately to Severely Active Ulcerative Colitis" ], "sites": [ "Birmingham", "Cambridge", "Sheffield" ], "enrollment": 100, "start_date": "2026-04-15", "registry_url": "https://clinicaltrials.gov/study/NCT07158242" }, { "nct_id": "NCT06451757", "title": "KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases", "status": "RECRUITING", "phase": "Phase 3", "lead_sponsor": "Khondrion BV", "conditions": [ "Mitochondrial Diseases", "Maternally Inherited Diabetes and Deafness (MIDD)", "Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS)", "Mitochondrial DNA tRNALeu(UUR) m.3243A