Ireland
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Priya Life Science Compound trial record
Compound · clinical trials

TYRA-300 clinical trials

Also listed in trial records as Dabogratinib (TYRA-300)
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 4 trials in our USA, Spain, France, Australia, UK, Netherlands, Sweden, Canada, Israel and Italy registers that name TYRA-300 as an intervention. Synced 10 Nov 2026
4Current trials
3Recruiting now
1Lead sponsor
10Country registers
At a glance

TYRA-300 is named as an intervention in 4 current clinical trials in our USA, Spain, France, Australia, UK, Netherlands, Sweden, Canada, Israel and Italy registers. 3 are recruiting patients now. The most common phase is Phase 2. The lead sponsor is Tyra Biosciences, Inc. The most-studied condition is Achondroplasia.

Patient leaflets for TYRA-300

The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.

  • UK
    United Kingdom: Search MHRA Products
    Patient information leaflets and SmPCs for UK-licensed products.
  • US
    United States: Search DailyMed
    FDA-approved labels, including patient and medication guides.

Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.

Trials by status

  • Recruiting375%
  • Active, closed125%

Trials by phase

  • Phase 2375%
  • Phase 1/2125%
01

Clinical trials of TYRA-300

4 trials
StudyPhaseStatusLead sponsorRegisters
A Study of TYRA-300 in Children With Achondroplasia: BEACH301
NCT06842355 · Achondroplasia
Phase 2 Recruiting Tyra Biosciences, Inc UK, USA, France, Spain, Netherlands, Sweden, Canada, Australia
Efficacy and Safety of TYRA-300 in Participants With FGFR3 Altered Low Grade, Intermediate Risk Non-Muscle Invasive Bladder Cancer
NCT06995677 · ClinicalTrials.gov ↗ · Low-grade NMIBC, FGFR Gene Amplification, FGFR Gene Alterations
Phase 2 Recruiting Tyra Biosciences, Inc USA, Spain, Italy, Australia
Phase 2A/B Efficacy and Safety of Dabogratinib in Participants With Low Grade Upper Tract Urothelial Carcinoma
NCT07265947 · Low Grade Upper Tract Urothelial Carcinoma
Phase 2 Recruiting Tyra Biosciences, Inc USA, France, Spain, Israel
Safety and Preliminary Anti-Tumor Activity of TYRA-300 in Advanced Urothelial Carcinoma and Other Solid Tumors With FGFR3 Gene Alterations
NCT05544552 · Locally Advanced Urothelial Carcinoma, Metastatic Urothelial Carcinoma, Solid Tumor
Phase 1/2 Active, closed Tyra Biosciences, Inc USA, France, Spain, Australia

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with TYRA-300

10 conditions
Achondroplasia1Low Grade Upper Tract Urothelial Carcinoma1Low-grade NMIBC1FGFR Gene Amplification1FGFR Gene Alterations1FGFR3 Gene Alteration1Locally Advanced Urothelial Carcinoma1Metastatic Urothelial Carcinoma1Solid Tumor1Urothelial Carcinoma1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Tyra Biosciences, Inc4
04

By country register

RegisterTrialsRecruiting
Clinical trials in USA43
Clinical trials in Spain43
Clinical trials in France32
Clinical trials in Australia32
Clinical trials in UK11
Clinical trials in Netherlands11
Clinical trials in Sweden11
Clinical trials in Canada11
Clinical trials in Israel11
Clinical trials in Italy11

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about TYRA-300 trials

How many clinical trials are testing TYRA-300?

4 current trials in our USA, Spain, France, Australia, UK, Netherlands, Sweden, Canada, Israel and Italy registers name TYRA-300 (also registered as Dabogratinib (TYRA-300)) as a drug or biological intervention, as of the registry sync on 10 November 2026. Completed and withdrawn studies are not counted.

Are TYRA-300 trials recruiting patients?

Yes. 3 of the 4 trials are recruiting: 3 with sites in USA, 3 with sites in Spain, 2 with sites in France, 2 with sites in Australia, 1 with sites in UK, 1 with sites in Netherlands, 1 with sites in Sweden, 1 with sites in Canada, 1 with sites in Israel and 1 with sites in Italy. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors TYRA-300 clinical trials?

The lead sponsor is Tyra Biosciences, Inc. The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how TYRA-300 works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how TYRA-300 works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists TYRA-300 (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 10 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.